association	dataset	threshold value	standardized value
BRD-K12984952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5424
Golgi membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
KASUMI2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6044
r4 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07018
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COPI-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.772
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K39649774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55894
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.874987
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_1066_KO_Esr1_SRP087718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.36088
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16331660_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79887
BRD-K48406740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19417
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.922103
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.84496
MARCKSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14806
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1435	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.15908
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4585
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
MET_knockout_252_GSE30651	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.86772
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22718
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF212	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549575
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08765
HDMYZ	CCLE Cell Line Gene CNV Profiles	-1.0	-2.7528
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5697
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306967
Blood-granulocyte	Tabula Sapiens Gene-Cell Associations	1.0	-0.169225
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86209
BRD-K93335719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63424
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HPAC	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.09568
A549_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260115
hsa-miR-1197	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-XBP1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28401
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278801
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hydroxyprogesterone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03242
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.884033
BRD-K79322550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31914
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173401
BRD-K66572611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26727
GSE200839,GSE233826_3_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.926315
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XYKS-1426-SM-4BRUO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904721
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
980_ATP5MPL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.579443
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5608
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NNC 26-9100	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.52
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47237224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22479
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.483
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61078
basal nucleus of meynert, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.913623
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Conventional (Clear Cell) Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78169
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TUBGCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24887
BRD-K87010860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76832
A549_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147235
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17589
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Fundus of striatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2087
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE186810,GSE186813_3_v_1_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BE-36-XE09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22888
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
BRD-K75041866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60738
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.600453
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC11103890-mmc3.xlsx-ZZZ3_interactors_ESC-2-Gene_names_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194206
BRD-K12930517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44321
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.14031
TP53-20018659-R1E-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224527
A549_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159067
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44458042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10089
Golgi membrane	GO Cellular Component Annotations 2023	1.0	null
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HIF3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557301
A549_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196
BRD-K18447546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49045
A549_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148026
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.59592
GTEX-OOBK-0625-SM-3LK5P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996449
BRD-K31342827_GF-109203X_WSUDLCL2_6.0_h_12.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE8	CCLE Cell Line Gene CNV Profiles	1.0	1.6304
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
DA-10-HD17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421569
UBTF	ENCODE Transcription Factor Targets	1.0	null
BRD-K29003210_OSSK_647368_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01067
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.875212
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4977
KML1	DepMap CRISPR Gene Dependency	1.0	2.69233
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pretectal region	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29641
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150565
PMC9746874-DataSheet1.PDF-43-TERF1_TERF1	Rummagene Transcription Factor Associations 2026	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238014
MCF7_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194508
inner SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.988217
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231872
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
prostate gland cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.467273
septal nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27813
C20orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51809
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265237
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K76829357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04049
GSE202603_0_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KYM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3591-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137738
MCF7_Regorafenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103193
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3184	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A54077041_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.85442
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.63496
OF-47-EQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267135
A549_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127697
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERFLCKJ	CCLE Cell Line Gene Expression Profiles	1.0	1.89247
16423883-Table1S	GeneSigDB Published Gene Signatures	1.0	null
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4961
19235837-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
H3K9ac_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217687
GSE154074_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154465
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209456
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-dORF6_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.52736
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1995_KD_Sun1/Sun2_SRP354599	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.91156
Perturb_8760_KO|KD_LATS1/LATS2|MK5_SRP222878	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Posterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.161
Golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K00020149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13753
BRD-K25690923_-666_COV644_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
K562_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145494
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_UNC1999_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132928
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03546460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98133
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.10207
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.988736
CF-42-OS28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35338
GSE186810,GSE186813_3_v_1_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X638-0326-SM-47JY1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18383
Blood Coagulation Disorders	CTD Gene-Disease Associations	1.0	1.01025
BRD-K20199304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23344
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.830739
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65155
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39206
Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56309
A549_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202222
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic islet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.272
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.640979
Oligodendroglioma_CNS - Brain (MMHCC)_GSE2223	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.03384
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-S7_Data_List_of_genes_upregulated_in_both_HEK293DAX_and_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832379
NCC010	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.1197
inner CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00556
CH-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.374
Squamous cell carcinoma of mouth_Oropharynx Epithelium_GSE3524	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.37733
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
A-VN-1203-2004(H5N1)_Day4-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.63531
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923802
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.864778
9473_U2AF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.698567
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16149
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.03807
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51411
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.29766
icSARS CoV_36Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.27029
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9613
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65663356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89552
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14392329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49771
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62009
A549_Bisindolylmaleimide IX_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151017
BRD-K07025286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39772
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08995
TAOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18208
r1 part of intermediate nucleus of the lateral lemniscus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15249
BRD-K12787259_CX-5461_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COPI-coated vesicle membrane	GO Cellular Component Annotations 2023	1.0	null
BRD-K11853856_PJ 34 hydrochloride_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4722-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52006
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.923674
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-423-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
K562_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0292087
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.524213
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568349
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD3	ChEA Transcription Factor Targets	1.0	null
A2058_SKIN	CCLE Cell Line Proteomics	1.0	4.87361
BRD-K12741517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16432
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04506
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0458
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.80108
SPI1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-55-SD64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201035
TBX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68634
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144774
BRD-K61168987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36684
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	2.00896
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34023
NCI-H196	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ventral subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16408
CRCGN015_MCF10A.WT.HP_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3408
CRCGN008_HEPG2_24H:B15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48105
BRD-K85441584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17708
suppressors	GeneRIF Biological Term Annotations	1.0	null
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251142
Silk gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29247
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151485
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.01103
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151505
BRD-K12824862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82925
upper basal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25276
SW620	CCLE Cell Line Gene Expression Profiles	-1.0	-2.20408
GSE154767_1_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
coated membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01531
COLO-680N	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.78033
HERC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55906
AA-52-JS03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.462238
A549_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152513
nucleus of the inferior collicular brachium, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.4131
KLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.009
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate-mast cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.169642
PMC11551338-pnas.2411189121.sd01.xlsx-AHR-Unnamed_0_AHR	Rummagene Transcription Factor Associations 2026	1.0	null
E2F4_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92317137_-666_EFO27_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K64958595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37663
inner SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03892
GSE88819_5_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
MB-15-ZF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412937
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
endoplasmic reticulum part	GO Cellular Component Annotations 2015	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endoplasmic reticulum quality control compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.978
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.97543
Sepsis	DisGeNET Gene-Disease Associations	1.0	null
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567928
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.304508
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57344
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.54495
BRD-K10513366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23459
salivarygland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.2785
organic substance transport	GO Biological Process Annotations 2015	1.0	null
BRD-K99131664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08056
NSC-625987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01434
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926553
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r8Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08759
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13443_KD_Taf2_SRP119047	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.92122
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01183
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
palbociclib_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185619
BRD-K82571240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60667
Larotrectinib sulfate_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0201393
dorsal part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12294
NDUFB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552227
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.463727
BRD-K41762421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71205
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083826
hsa-miR-342-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04064
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833104
Muscular Dystrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2629	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.11652
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945214
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE188869,GSE188871_2_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.797926
superficial stratum of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29212
ST3GAL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407273
NCIH2171	Achilles Cell Line Gene Essentiality Profiles	1.0	1.59962
BRD-K24514314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15832
K562_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169381
BRD-K23405268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14219
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.387
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
6803_PRPF8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23085
GSE93156_1_v_0_idelalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RT112	DepMap CRISPR Gene Dependency	1.0	2.85854
K562_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016891
JHOS2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53671
Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TSSK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633956
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25694
BRD-K67665252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70537
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843149
WIPI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2386
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K68548958_-666_HA1E_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K16621460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04376
AB-86-XY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21629
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.994209
BRD-K48143921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19989
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23464
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81801123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33583
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.44242
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XUJ4-1226-SM-4BOPD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938639
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.213
GTEX-XUZC-1626-SM-4BRVP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1508
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K69594935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32509
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of r1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01486
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate (interpositus) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05877
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160817_0_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K78599730_manumycin A_THP1_6.0_h_9.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
17023574-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Mechanical Allodynia	DisGeNET Gene-Phenotype Associations	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.61403
AD-34-TG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.510317
Labyrinthine zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176361
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1489
BRD-K77677632_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39113
MAX	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AI-1126-SM-48U19	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01573
MCF7_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110218
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.31686
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39899
WNK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00451993
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02246
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ascomycin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.37
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
MDST8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45881
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LNCAP	BioGPS Cell Line Gene Expression Profiles	1.0	0.849052
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054966
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE110178_4_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cyst wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.731
K562_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172326
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8482
BRD-A23193246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35743
PMC7397849-supp_gad.338681.120_Supplemental_Table_S2.xlsx-S2B_in_vivo_shared-Suppl_Table_S2B_shared_genes_between_RCAS-YAP1-MAMLD1-dR3R1_RCAS-YAP1-FAM118B_RCAS-YAP1-TFE3_in_vivo_tumors_RCAS_mouse_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
GE-22-ME44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238089
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35928
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pons	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.845705
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274155
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.7517
CLPTM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06694
PMC8759131-advancesADV2021004469-suppl2.xlsx-Table_S1-Supplementary_Table_1_Differentially_expressed_genes_post_knockout_of_MEF2D_in_MOLM-13_AML_cells_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120612_4_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194807
BRD-K56428170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13922
GTEX-VJYA-0726-SM-4KL1T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834595
Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-0826-SM-4LVMI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82856
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133738
periventricular stratum of r2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28506
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914537
superficial stratum of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3815
BRD-K14306031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44163
Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_12993_KO_Il1rl1_SRP274117	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.1156
Perturb_5331_KO_Myc/Mycn_ERP009787	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.46325
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17368
periventricular stratum of r4Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21885
CA-68-TC79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288195
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.210518
E2F4-21247883-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5373
NCIH1436	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53486
GTEX-QESD-1426-SM-2S1R9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860489
NT5DC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433502
BRD-K91410469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50922
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K10876822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37777
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63068307_S1072_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K97365803_PI 828_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLC66A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41748
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.19027
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
protein transport	GO Biological Process Annotations 2023	1.0	null
IMR32	DepMap CRISPR Gene Dependency	1.0	5.94547
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16698
MCF7_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110191
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42545
CHD7	ENCODE Transcription Factor Targets	1.0	null
GSE201309_5_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K33998683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51795
mRNA_EP400_22196727	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.029
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K02822062_CT-200783_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HT3	DepMap CRISPR Gene Dependency	1.0	4.17718
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.895215
GSE233183,GSE233187_3_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE245270_1_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10806
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.900769
PMC8635809-Table_2.xls-LPS-downregulated-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07032
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37448
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
A549_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187669
496100561_PCx_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.54953
TE-26-XS06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342841
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
YE-80-LN04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422804
CRCGN015_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3607
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.576207
male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.201635
BRD-K66807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75781
SPDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27448
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.835349
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.24471
corticoid layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2754
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.654037
AA-46-GL76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.381995
CST7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407452
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61315
BRD-K87375115_KM00799_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lung	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40059
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.67459
ventral posterolateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70695
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448932
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ventral posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25101
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38617
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A14878925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44715
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6768
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144231_6_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	4.13822
GSE148692,GSE148695_5_v_6_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
gemcitabine_homo sapiens_gpl96_gse6914	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC515	DepMap CRISPR Gene Dependency	1.0	2.60356
Presubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19802
PANX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57223
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Coated vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-A84327315_71820_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AE-79-LG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345702
MAFK	ENCODE Transcription Factor Targets	1.0	null
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
COLO-678	GDSC Cell Line Gene Expression Profiles	-1.0	-2.60116
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76848
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K23ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BA-52-FW03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277108
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845455
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
D-336MG	GDSC Cell Line Gene Expression Profiles	1.0	1.71472
OC-71-BZ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200802
CE-04-HT15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238747
BRD-K60751806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24039
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02276
Liver Diseases	CTD Gene-Disease Associations	1.0	1.48684
GSE198165,GSE198166_9_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPARG	ChEA Transcription Factor Targets	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02806
BRD-K36464765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06701
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
SKMEL28	BioGPS Cell Line Gene Expression Profiles	1.0	2.19235
TPRKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00369804
NCIH2126	CCLE Cell Line Gene Expression Profiles	1.0	2.3532
22RV1	DepMap CRISPR Gene Dependency	1.0	4.10372
MDAMB361	DepMap CRISPR Gene Dependency	1.0	3.40019
GSE81193_3_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8419
GSE232631_4_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-M86331534_BJM-ctd2-9_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KRTAP13-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93113
8222_SNRNP70_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.46312
BRD-K13566078_HY-10518_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K35240878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33477
9938_YKT6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38795
BRD-K63587749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81507
BRD-K66821167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17748
COPI vesicle coat	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Medial geniculate complex, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66259
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2159
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-76-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21749
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.85876
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6793-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOT4-0626-SM-4B66L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923173
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.58382
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE149760_0_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Salivary_Gland-acinar cell of salivary gland	Tabula Sapiens Gene-Cell Associations	1.0	19.2217
LUDLU1	DepMap CRISPR Gene Dependency	1.0	5.13754
GSE214596,GSE214598_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6076
miR-targeted genes in leukocytes - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
BRD-K76539747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10126
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.6742
BRD-K66580188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14555
POU2F2	ENCODE Transcription Factor Targets	1.0	null
intracellular protein transport	GO Biological Process Annotations 2025	1.0	null
BRD-K29028138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07218
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE167404_1_v_0_lama4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.20472
GTEX-Q2AI-0826-SM-48TZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18359
u937	HPA Cell Line Gene Expression Profiles	1.0	1.0293
nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.1876
endoplasmic reticulum-Golgi intermediate compartment membrane	GO Cellular Component Annotations 2023	1.0	null
DMS153	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67797
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4877
BRD-K45859834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60324
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endomembrane system organization	GO Biological Process Annotations 2025	1.0	null
CD93	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00686301
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47604
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EB-09-JJ93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327108
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.859549
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_RAD21_21589869	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.875718
endoplasmic reticulum to Golgi vesicle-mediated transport	GO Biological Process Annotations 2025	1.0	null
copi vesicle coat	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.118
HMX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0737
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19371
PMC7423359-abb8771_Table_S4.xlsx-Sheet1-Genes_detected_at_least_twice_in_h4E_BP1-hyperTRIBE_711_genes_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MQ-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Amylin receptor complex 2	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.124
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1326
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267503
BRD-K35588268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02948
MC-51-BT07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2992
5422_NAA10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17419
A549_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200714
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92428232_HY-50877_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAP3K4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00727893
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10031593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35922
TB-06-VB30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477604
IC-15-FM25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205269
periventricular stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07018
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26524
AE-04-SN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422437
Perturb_3817_KO_Atoh1_SRP076034	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.05587
BRD-K38766433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38816
BRD-K89932793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69416
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-1126-SM-4BOPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32316
alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COPI-coated vesicle membrane	GO Cellular Component Annotations 2025	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.941627
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HAL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064022
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.688
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
MYC-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
A549_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148316
GSE206729_5_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154081_1_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_AGS_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.982397
GTEX-PVOW-1626-SM-48TC9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29208
BRD-K37510443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27267
NCIH1105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46381
HD-29-PZ41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.565837
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2323
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WN-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
virion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.332848
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.43212
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33295
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AA-46-GL76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246748
CTCF	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.75242
BRD-K68336408_Tyrphostin AG 1478_MCF7_24.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU1272	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5606
GTEX-SE5C-1126-SM-4BRWZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14924
BRD-K05323277_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.0436
PMC4090731-bjc2014262x1.xls-Sheet1-CaSig-HSF1_Positive_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
RNF32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621894
BRD-K88000297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35254
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CT-01A-31R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125239
NCIH28	DepMap CRISPR Gene Dependency	1.0	2.20731
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57351
GTEX-X4EP-0126-SM-3P5YV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2539
GSE116299_6_v_5_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFG7-1126-SM-4LMK3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912611
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KANSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058057
golgi apparatus part	GO Cellular Component Annotations 2015	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0673
A549_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141159
AD-51-LE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362921
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.902843
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.936878
GSE211474,GSE212779_0_v_1_phf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.8603
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OUMS23	DepMap CRISPR Gene Dependency	1.0	3.4686
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_downregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3458-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28919
BRD-A46747628_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A64O-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92879007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12431
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041696
BRD-K51363316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10212
BRD-K76628294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31668
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.961896
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K98535230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35214
MCF7_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140258
CRCGN015_MCF10A.TP53.M_24H:M09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1223
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
16498405-TableS4	GeneSigDB Published Gene Signatures	1.0	null
Sarcoma_SARC_TCGA-IE-A4EI-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90349877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03761
BRD-A47706533_C1386_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vitamin c_mus musculus_gpl1261_gse37676	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CA-72-JV60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.387907
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0843
CHD2	ENCODE Transcription Factor Targets	1.0	null
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28878
RF-04-GI28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23427
FOXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40446
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LTK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696718
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16492
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03808
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endoplasmic reticulum-Golgi intermediate compartment membrane	GO Cellular Component Annotations 2025	1.0	null
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.67449
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.665434
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOMO1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.04843
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18310505-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K71758378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16944
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78467
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153325
HD-18-YL30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203545
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_101_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A19500257_geldanamycin_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163749
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.15256
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170645
striatal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01667
MCF7_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138428
BRD-K36031198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00619
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.76757
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68F-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129285
BRD-A93015352_2378-0086_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Papillary thyroid cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.134
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
paraventricular nucleus, peduncular or principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57961
BRD-K88498468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35933
Tubulin inhibitor 6_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208999
sp1_22099172_dental_follicle_cell_gof_human_gpl11532_gse31628	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.521673
A549_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233512
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058182
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255486
PMC4686761-ncomms10068-s3.xlsx-S2E-MSC_up_specific-Supplementary_Data_2E_-_expression_of_up-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0769
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K09499853_KU 0060648 trihydrochloride_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05548
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Golgi-associated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04183
BRD-K28907958_-666_NOMO1_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K65773140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40212
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.20812
Lung adenocarcinoma_LUAD_TCGA-35-3615-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.623
GTEX-V1D1-1926-SM-4JBGX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831815
ZFX-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.90029
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5513
CRCGN008_HEPG2_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2848
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.10855
Lung squamous cell carcinoma_LUSC_TCGA-66-2771-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013743
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28174
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201301
SKMEL3	CCLE Cell Line Gene Expression Profiles	1.0	2.88531
BRD-K96997646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41505
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.86185
Sarcoma_SARC_TCGA-DX-A240-01A-32R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carcinoma	CTD Gene-Disease Associations	1.0	1.11843
Perturb_16456_KO_CHUK_SRP229998	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54941
HCC1897	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57603
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.99378
increased circulating iron level	MGI Mouse Phenotype Associations 2023	1.0	null
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26103
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MT-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28558
RAB3A_KO_GDS2483_700_mouse_Cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.726
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65829768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0298
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD-97-ZV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457533
DE-10-AU63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33263
Perturb_10712_KO_Nrf2_SRP336215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.62149
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19947
E2F4	ChEA Transcription Factor Targets	1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.02262
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16149
Perturb_1728_KO_Mdmx/Spi1_SRP301763	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.51492
MCF7_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174793
AF-01-FE42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365497
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
claustrum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.840635
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.864734
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7835
PMC7613740-EMS124720-supplement-Suppplementary_Tables.xlsx-S6_Immune_evasion_signature-Table_S6_Genes_comprising_IES_displayed_as_RTT_vs_NTT_up_and_downregualted_seperately_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.34982
COPII-coated ER to Golgi transport vesicle	GO Cellular Component Annotations 2025	1.0	null
MCF7_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143912
PML	ENCODE Transcription Factor Targets	1.0	null
A549_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202153
A549_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197453
GSE162276_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WH7G-2026-SM-3NMBL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04845
S100A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544819
Globus pallidus, internal segment	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37759
GSE155305_3_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13456
GSE227415_1_v_0_ucp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.705092
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21132
salivarygland_6a	HPA Tissue Sample Gene Expression Profiles	1.0	2.67486
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.974726
DB-29-HQ45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323945
BRD-K32120119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8039
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
BRD-K88868628_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K77987635_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BB-86-BE39_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447844
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0595
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.6652
BRD-K02053819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07034
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.872044
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151202
GSE218960_0_v_1_nrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.09897
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19552
ATF3	ENCODE Transcription Factor Targets	1.0	null
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02715
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3538
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00386
Blood-plasmacytoid dendritic cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.169642
BRD-K33217094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42954
18593951-TableS2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K16267084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14166
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2122	CCLE Cell Line Gene Expression Profiles	1.0	1.48736
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
IC-80-CT90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251653
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.852249
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.81473
BRD-K23701005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60315
BRD-K96491664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83132
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866026
537_ARPC3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.705735
SREK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0070102
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172022
BRD-K32862383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12854
Memory Disorders	CTD Gene-Disease Associations	1.0	1.09716
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-79-SX47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243623
LY2090314_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250571
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242103
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40763
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreas	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.03833
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.97734
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.774424
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.62429
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160657
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04905
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.609
Lung adenocarcinoma_LUAD_TCGA-05-4420-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9314667-Table_1.xlsx-Regulons-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44814060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21359
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.02844
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.836709
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41684304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93697
TACC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31252
COPII vesicles tethering complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.236
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2547
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39341
Golgi-associated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.48
APECED - Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy_Thymic epithelial cell_GSE85	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	3.62974
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
prostate gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.216933
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.22746
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856115
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.831773
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33658
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43288
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041052
4088_IK_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18181
Perturb_9015_KD_ZNF827_SRP318474	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K29395450_PIK-93_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BA-53-FM66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.541796
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08607
BRD-K02565327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39278
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.09929
GMPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00477511
intermediate stratum of m2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10258
A549_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143626
FB-98-HM88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205562
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.74151
DIPK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32249
MAC2A	DepMap CRISPR Gene Dependency	1.0	2.29913
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_downregulated_RRHO_list-Unnamed_35_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859656
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32869
BRD-K73689413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53953
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.19697
cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36813
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92177
FLI1	ChEA Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09878
BRD-K63155804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00399
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0184
ELK1	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34371
EREG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521528
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
SBI-0640756_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0236171
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66514
BRD-K26127722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24443
mnng/hos	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Muscular Dystrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2507	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.16582
BRD-K88278225_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKNFI	CCLE Cell Line Gene CNV Profiles	1.0	1.45421
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A04618830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30773
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3201
cerebellar cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38481
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2137
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A10523515_HY-11000_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AB-09-YX02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271615
AD-58-PW17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464254
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68174511_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE201309_1_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
COPI-coated vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K54606188_(+)-JQ1_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K26251149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83257
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S3-MECOM_up_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9118
Ouabain (Octahydrate)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0181668
A549_Ofloxacin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121406
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81949875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85191
Perturb_4308_KO_FOXM1_SRP328179	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CD1E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006075
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123022,GSE123030_2_v_6_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154389
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r2 part of vestibular nucleus Y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49327
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207694
MDAMB453	CCLE Cell Line Gene CNV Profiles	-1.0	-2.31604
GTEX-O5YV-1026-SM-3LK72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3635
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3071
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE144443_0_v_6_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PLK3_knockdown_121_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.58318
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X3-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K53356402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6906
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.909398
BRD-A35588707_TENIPOSIDE_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endoplasmic reticulum membrane	GO Cellular Component Annotations 2015	1.0	null
K562_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015482
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0294
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43955
TBP	ENCODE Transcription Factor Targets	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
SK-MEL-3	GDSC Cell Line Gene Expression Profiles	1.0	1.58215
BRD-K42435237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89753
Rectum adenocarcinoma_READ_TCGA-F5-6814-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.424
RBSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02101
USHBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10345
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
r11 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57451
BRD-K35066174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03626
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.24394
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.904821
GUCY2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621787
Peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
A549_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193878
GSE143662_0_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54059
BRD-K38477985_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00999505
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KNS60	CCLE Cell Line Gene CNV Profiles	1.0	1.35899
7836_SF3B2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.048
GSE141328_3_v_2_rock2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169497
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A35588707_TENIPOSIDE_NOMO1_6.0_h_1.25_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_T3M10_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WB-54-WD35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271663
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43324
BRD-K92241597_CHR 2797_U937_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37760996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10788
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0806
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58607444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03568
PMC9314667-Table_1.xlsx-Regulons-ELF1_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
Golgi organization	GO Biological Process Annotations 2025	1.0	null
BRD-M07419510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36621
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TMP21-related	InterPro Predicted Protein Domain Annotations	1.0	null
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYBS-1926-SM-3NM8N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37941
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3417-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-HEK_and_SupT1_up_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K75807957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88891
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-85-VH07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262486
CBX3	ENCODE Transcription Factor Targets	1.0	null
NCIH2227	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51953
Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
after	GeneRIF Biological Term Annotations	1.0	null
BRD-K65933652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95654
Perturb_5050_KO_Pcgf6_SRP078684	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.82304
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856708
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MF-11-EW49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.614886
SMAD3-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.79833
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33023
r1 part of vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36352
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-A55574211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75819
Oxaliplatin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0151059
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.59
MCF7_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183659
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CF-42-OS28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289698
BRD-K04785821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42832
r2 part of principal trigeminal sensory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38207
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.04251
BRD-K02708799_GSK-1059615_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Paraventricular hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03951
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.50556
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.27768
BRD-A94740628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57794
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1435
Lung adenocarcinoma_LUAD_TCGA-50-5072-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1187	Achilles Cell Line Gene Essentiality Profiles	1.0	2.8922
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76353834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6847
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.612
GTEX-X4XY-0226-SM-4E3IZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854402
MCF7_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154896
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.04878
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EB-09-LQ45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204587
intermediate stratum of m1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03101
BRD-K93457574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04554
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.924066
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09111
Nucleus of the lateral olfactory tract, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2659
coated vesicle	GO Cellular Component Annotations 2023	1.0	null
F5	DepMap CRISPR Gene Dependency	1.0	4.241
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-1426-SM-447AC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833795
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838564
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GC-07-UO80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322073
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1733
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56942203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33346
Colorectal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
16872506-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3435
BRD-K74705119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43002
GTEX-OIZG-1026-SM-3LK5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43829
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cytoplasmic vesicle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.895649
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276471
JVE015	DepMap CRISPR Gene Dependency	1.0	4.54827
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168054
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24911
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882619
CAL-12T	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.72496
INTS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78793
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23212
BRD-K48195722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31221
HDAC1	ENCODE Transcription Factor Targets	1.0	null
MCF7_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159575
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49526793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52311
BRD-K13472433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36223
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RD-92-QT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.765678
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.502
CA-48-SW47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30623
NCIH1876	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87372
BRD-K86961579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04539
blastocysts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.99331
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC43A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495594
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.56904
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
no-11	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.93053
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32803
TFAP2A	ChEA Transcription Factor Targets	1.0	null
BRD-K30381304_OSSK_645668_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275038
GSE228181_0_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17753780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39627
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.881917
Perturb_16458_KO_CHUK_SRP229998	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181289
SEPHS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05668
GTEX-XXEK-0826-SM-4BRWG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927928
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16611
BD-93-AM31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233034
LS411N_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.5009
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55889
PMC10534007-Table_2.xlsx-S1_overlap_MSC_up_B_V-438_common_elements_in_BFTC905_MSC_up_and_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900591
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAFF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00651149
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EFE184	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3592
GTEX-SE5C-1226-SM-4BRWV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914602
virion part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.335487
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7207
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42814713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43053
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.22748
GSE168676_2_v_3_dach1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.878296
Bone cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
BRD-K96491043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44696
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86472598_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Embryo Loss	CTD Gene-Disease Associations	1.0	1.02188
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16961
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AA-88-PJ86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.484497
Paraventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75306
BRD-K24350933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2032
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.25717
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123668
A549_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166778
Vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.522
GSE154767_1_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05266
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.952972
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.946064
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17615
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO1_KD_GDS2720_477_mouse_LSK	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC11399402-41598_2024_72406_MOESM3_ESM.pdf-2-NFKB1_NFKB1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103419
BRD-K20285085_R406_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
K562_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144984
BRD-A57107094_2326-3228_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
ALG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46286
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K02614439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0759
FOXA1-21915096-LNCAP-1F5-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC11839186-CPR-58-e13756-s004.pdf-71-THAP3_THAP3	Rummagene Transcription Factor Associations 2026	1.0	null
internal globus pallidus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10213
BRD-A38359809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39217
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826494
Salivarygland	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.85575
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20402
BRD-K97761115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07371
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21543
gentamycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48354
BRD-K19536737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09751
BRD-K11853856_PJ 34 hydrochloride_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-1526-SM-4DXUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16613
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-1626-SM-3K2AY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43481
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
BRD-K10481024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29214
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175959
BRD-K47854067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38635
GTEX-XYKS-2426-SM-4AT43	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10342
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LGLL - Large granular lymphocytic leukemia_Peripheral blood mononuclear cell_GSE10631	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.5418
BRD-K45519638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0815
SNU620	DepMap CRISPR Gene Dependency	1.0	2.6431
BRD-K47673408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33945
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1064
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78867378_mw-A1-12_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K86600397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59149
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ER to Golgi transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.535
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86301
BRD-K54100199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31643
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.448
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH1694	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47941
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
methotrexate_homo sapiens_gpl571_gse9412	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K29784863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31881
BRD-K71139459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34186
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BT-483	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.26891
BRD-K15025317_Bay 11-7821_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.956002
BRD-A08610364_NCGC00181375-01_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05255
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.228119
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1354
BRD-K11641139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10122
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149228
MDAPCA2B	CCLE Cell Line Gene Expression Profiles	1.0	1.66326
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139540_4_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	1.51764
SW620	GDSC Cell Line Gene Expression Profiles	-1.0	-3.53725
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02413
MCF7_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262976
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Dronedarone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
D-336MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RVPU-2226-SM-2XCAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852694
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75440064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41127
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0598
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146247_0_v_1_sirt7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_1729_KO_Spi1_SRP301763	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.699
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23207
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18208
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133551
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4954
PLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049892
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50362
MCF7_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118512
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08768
BRD-K39547688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16427
TNFRSF13C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051416
SW480	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25249
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1568	CCLE Cell Line Gene CNV Profiles	1.0	1.42857
BRD-K18173053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09937
BRD-K79833963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90922
prostate	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.15389
GTEX-QEG5-1426-SM-447AS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98203
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAPOLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13771
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23177
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.660949
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199173
BRD-A02333338_C3393M50_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
BRD-A13021932_BMS509744_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF7_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157031
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.478138
Nucleus sagulum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05451
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77757
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52281
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47205
BRD-K98089885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44899
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.47617
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873424
BB-93-VT73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466059
Fatty Liver	CTD Gene-Disease Associations	1.0	1.40953
A549_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0344006
GTEX-PWOO-1226-SM-48TCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08937
A549_Aurora A Inhibitor I_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129105
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
m1Lim part of the midbrain reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02815
BRD-K37433647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16141
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
estradiol_homo sapiens_gpl570_gse16683	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-0.841482
JHH5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07712
ethanol_rattus norvegicus_gpl341_gds2107	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.203275
Cancer of thyroid_Thyroid_GSE5364	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.08634
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
anterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03903
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.62483
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-73-4670-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306332
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.876671
COLO-741	GDSC Cell Line Gene Expression Profiles	1.0	1.66321
SARS-dORF6_60Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.66827
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	2.36085
MNNG/HOS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44575
A549_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021424
AA-52-JS03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.470655
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30352
lower dorsal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3627
superficial stratum of CoPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34655
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TSPAN32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664672
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116299_4_v_3_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH2887	DepMap CRISPR Gene Dependency	1.0	2.65444
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.54374
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15537
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26844
MET_knockout_262_GSE8747	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.06433
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.13552
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251511
CREB3L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70561
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937379
K562_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195751
SPG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69024
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78692
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prostate_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.861037
BRD-K88739137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09752
ZB-33-MZ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238895
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.851703
EPZ004777	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
BRD-K91191855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1828
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.24582
GSE245134_0_v_1_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2A-17053090-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ME-54-JY76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.391278
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
IC-80-CT90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213762
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
karpas707	HPA Cell Line Gene Expression Profiles	-1.0	-2.39936
H3K36me3_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.02596
PIM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509104
A549_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237054
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.7597
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.843214
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.24315
BRD-K21729626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05555
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4122
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.20184
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SNU-C5	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.89338
GSE193993_0_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02383
NRF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164434
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7SF-0926-SM-4AD4M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27895
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.7761
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.05085
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8776
A549_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143493
GTEX-XYKS-1526-SM-4BRUP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16575
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.2068
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37437
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
20860821-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GTEX-O5YW-0126-SM-3LK6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25404
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83255
PPIL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00698571
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73539077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55685
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.27482
BRD-A69336132_KM 04501_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919857
GTEX-XUJ4-2426-SM-4BOO3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14049
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186136
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909783
TEF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06314
DF-93-BT88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.47895
BRD-K81160595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55175
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61788
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COL18A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0075294
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0564
18310505-TableS7	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.857055
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849915
BRD-K60839995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21824
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966787
MORCPR	CCLE Cell Line Gene CNV Profiles	1.0	2.1424
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SD-82-GT69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234052
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.51637
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.99584
GABP-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
COLO678	CCLE Cell Line Gene CNV Profiles	-1.0	-2.24088
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.52388
EA-84-SC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219011
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.888146
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58847
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.87653
PHF8	ChEA Transcription Factor Targets	1.0	null
BRD-K12801140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.565
GM2345	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.43002
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.561831
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.931004
Post-translational protein modification	Reactome Pathways 2024	1.0	null
BRD-A19500257_geldanamycin_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.35735
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26339
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-TS-A7P6-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BB-64-EE60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342451
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266534
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cyclin D1-CDK4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.733
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.56706
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3166
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.967975
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.26629
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BRD-K69238239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17011
erg	GeneRIF Biological Term Annotations	1.0	null
GSE101239_5_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06623064_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.452
GSE163275_1_v_0_irf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47511177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05737
H4C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28283
GTEX-P4PP-1526-SM-3P61M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03312
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.677964
NCIH1105	CCLE Cell Line Gene Expression Profiles	-1.0	-2.00446
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12589
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2147
BB-86-BE19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.731999
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.874169
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.734267
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.867745
A549_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253926
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
4949_MED26_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14095
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.981216
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hMPV_72Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.698036
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.22126
BRD-A19037878_trichostatin A_SKMEL28_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44779507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30692
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S9-ZNF384_SpecDMCs-Unnamed_3_ZNF384	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55721
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11356
hsa-miR-1225-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.6456
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.617
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06089
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371654
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4221
hsa-miR-1178	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.68084
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GC-73-YI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205017
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05351
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 1 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2007
DE-09-HJ53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203489
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2HX-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05167
GSE65617_5_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC2A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559324
CC-18-YW57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.408398
BRD-K04548931_EPIRUBICIN HYDROCHLORIDE_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43332
RMUGS	DepMap CRISPR Gene Dependency	1.0	2.06449
Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.41195
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.73881
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58502
BRD-K29728947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33703
ELK1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982984
mRNA_SOX2_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K19731191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57454
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.965271
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SW1417	Achilles Cell Line Gene Essentiality Profiles	1.0	1.43349
KLF4	ChEA Transcription Factor Targets	1.0	null
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.46087
Vemurafenib_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146166
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051147
BRD-K59542165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47853
GTEX-XMK1-1126-SM-4IHJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92012
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234014
Medial geniculate complex, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16187
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01565
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209132
GSE242083,GSE242098_3_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ME-11-OJ38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28576
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KW-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.83867
HF-00-QG19_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247402
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4396-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAK-901_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0111492
protein localization	GO Biological Process Annotations 2015	1.0	null
Perturb_7188_OE_TMEM119_SRP279053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.559
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
lncap cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.543756
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65011
GSE147876,GSE147877_4_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
parahippocampal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.857982
GSE87615_2_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245543
496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05128
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.90109
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.964211
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-j-Classification_of_all_differentially_expressed_genes_DEGs_by_WD_in_camel_SON_SON	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932938
A549_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140787
U-87-MG	GDSC Cell Line Gene Expression Profiles	1.0	1.54295
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17479
A549_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168016
GSE131680_1_v_0_macroh2a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22935
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10636
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81577
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WEY5-1926-SM-3GIL8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851354
COLO684	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46066
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16037
BE-07-XI66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211862
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2922
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
vesicle coat	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869796
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.558461
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237917
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909518
BRD-K28874552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21412
CEP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05816
posterior triangular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64007
NCI-H1573	GDSC Cell Line Gene Expression Profiles	1.0	1.66662
BRD-K57179821_483-63-6_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K83276573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06366
BRD-A95820578_NP-006304_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48097
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar vermis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.980929
BRD-K52157065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03811
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264456
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194693
GTEX-X62O-2226-SM-46MW3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24119
GSE173201_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1836	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75139
Perturb_14044_KD_Osr1_SRP073488	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PKHD1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00598064
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.0866
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LPXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5738
BRD-K76703230_YM-155_RKO_6.0_h_0.310000002384_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.00634
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19166598_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K98714523_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
fat_a.V1	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.02811
GTEX-T5JW-0926-SM-4DM5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855776
GSE87615_0_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A20968261_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OMC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A89907244_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CB-15-RU50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.639872
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438282
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.893831
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42773
Bradyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.938
MAFF	ENCODE Transcription Factor Targets	1.0	null
PMC11551338-pnas.2411189121.sd01.xlsx-PXR-Unnamed_0_NR1I2	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A28153253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53476
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279352
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.448638
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7933708-mmc2.xlsx-DNMT-target_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16884
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21136
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24167
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1264
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2218	CCLE Cell Line Gene Expression Profiles	1.0	1.80664
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8975_TMED3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.703223
MHHCALL3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94327
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42413
H3K27ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5521-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23451
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-24-AT90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03115
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-86-ES28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359359
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75454
PC-87-OG75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.468948
OE33	DepMap CRISPR Gene Dependency	1.0	2.43859
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
HS683	Achilles Cell Line Gene Essentiality Profiles	1.0	1.20076
GTEX-X88G-0326-SM-47JZ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05464
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
2112_DDX23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.43231
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01481
TBC1D7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067655
BRD-K33260002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31692
prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.207578
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
GM1600	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.70973
GSE147626_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2043
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.96343
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9171
FNBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20427
MCF7_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119997
RNF168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33563
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45783
WIPF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545016
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68408
BRD-A94756469_DIGOXIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH854	CCLE Cell Line Gene CNV Profiles	-1.0	-2.19761
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.99856
TCF3	ENCODE Transcription Factor Targets	1.0	null
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Transport to the Golgi and subsequent modification	Reactome Pathways 2024	1.0	null
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61886116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39282
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RB-34-TO07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21356
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82102697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32089
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PA-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57236
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.956503
CD-26-MB82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330104
BRD-K17063694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27008
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231924
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1437	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.20621
BAY 61-3606	DeepCoverMOA Drug Mechanisms of Action	1.0	0.93
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14757
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06491
Nrf-1	MotifMap Predicted Transcription Factor Targets	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF-00-QK19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434205
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NFK9-0226-SM-2HMKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881104
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
5933_OGT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.66045
BRD-K50177754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38892
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XV7Q-2926-SM-4BRUL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10547
CGAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582444
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126787
CLDND1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542305
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28077
6802_PRPF6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2971
Sublaterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04787
P30-OHK	GDSC Cell Line Gene Expression Profiles	-1.0	-2.10333
Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11626
ParietalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.925712
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A6BG-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74324157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38454
19168792-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12705251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50638
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.98606
BRD-K72687327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25344
BRD-K04887706_Akti-1/2_U937_6.0_h_9.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K47275094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36413
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-0926-SM-48TC1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14329
BRD-K43789905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10937
periventricular stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58074
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22584
8222_SNRNP70_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.926237
prostate cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.382508
GSE233679_12_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RMUGS	CCLE Cell Line Gene Expression Profiles	1.0	1.38705
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131578
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33405
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11618
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.838779
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.74855
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056038
WHSC1	ENCODE Transcription Factor Targets	1.0	null
pyramidal layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.843631
U343	CCLE Cell Line Gene Expression Profiles	1.0	2.09464
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K90157100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47075
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17096
endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
A549_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176951
golgi apparatus part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A3-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JQ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU520	CCLE Cell Line Gene Expression Profiles	1.0	2.1644
SMAD4	ChEA Transcription Factor Targets	1.0	null
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936351
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02124
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85283
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mammary-nk cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.169642
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88313
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.517177
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TML8-1926-SM-32QOS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15166
A549_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145707
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939263
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.57526
MCF7_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153505
MTCH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1662
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218727_2_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.19093
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163416
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01375
Golgi-to-ER retrograde transport	Reactome Pathways 2024	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314136
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09105
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49345010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67571
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179002_2_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.2406
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6849-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1729
BRD-K02374169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35785
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KAT2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0040599
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.028801
copi-coated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
golgi membrane	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
direct	GeneRIF Biological Term Annotations	1.0	null
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2126	GDSC Cell Line Gene Expression Profiles	1.0	1.97214
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A15086915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.66518
Perturb_10866_KO_Hsf1_SRP116890	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.21013
HCC2218	Achilles Cell Line Gene Essentiality Profiles	1.0	1.01209
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.27522
MCF7_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173211
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.41593
Abiraterone acetate_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00505958
BRD-K52170475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70981
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.173629
tamoxifen_mus musculus_gpl7202_gse29715	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21719
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_4_FDC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8437
A549_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014337
BRD-K37564297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22031
BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_NOMO1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Retinitis Pigmentosa	DisGeNET Gene-Disease Associations	1.0	null
DC-84-CJ21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261701
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13295
AA-27-TF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223472
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08218
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940088
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87264606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10921
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A69M-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5945
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04939
BRD-A69648159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01972
BRD-K01182779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3576
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HA-32-YH61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221144
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36961619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33823
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.915082
EC-07-AO30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.442694
TSHZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24764
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255267
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05484
KNS42	DepMap CRISPR Gene Dependency	1.0	3.36381
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K84241565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18072
A549_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137822
15474998-tableS1a	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168596_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE80098,GSE80366_0_v_6_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6909-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
BRD-K95785537_PP 2_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K57517066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15578
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testosterone_mus musculus_gpl1261_gse17553	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K60623809_SU11652_COV644_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4857
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.922614
methotrexate_homo sapiens_gpl570_gse11440	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.314
SKOV3	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.22103
etoposide_homo sapiens_gpl10558_gse33990	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LB831-BLC	GDSC Cell Line Gene Expression Profiles	-1.0	-2.33067
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187704
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26045
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00871
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59165
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07861364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5924
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K26214026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8404
A3-KAW	GDSC Cell Line Gene Expression Profiles	1.0	1.58671
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89437
BC-61-ZY95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.364589
BRD-K64111129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79528
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.632296
K562_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170802
prostate gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.379123
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1Q0-01A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140766
BRD-A36275421_MW-ras12_NCIH508_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234202
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3272
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.31338
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QS-0008-SM-48TDY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830656
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24211
SOX2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K05118861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48063
BRD-K38615104_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COPI-coated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-A02927672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83846
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946389
BRD-K16231990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.368
GTEX-XBEW-1326-SM-4AT63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852984
CE-23-HP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410708
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4719
PANX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487454
r9 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01875
GSE169155_5_v_4_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Lateral terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17648
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BI-78D3_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0157263
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A28932952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09141
GTEX-OIZH-0126-SM-2HMIS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52116
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.37172
DMS79	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36507
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2579
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.970474
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.1918
GTEX-T6MO-0526-SM-4DM6R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02083
BRD-K72083510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32238
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0508
Adrenocortical carcinoma_ACC_TCGA-OR-A5JX-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835917
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MIA PACA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926553
endomembrane system organization	GO Biological Process Annotations 2023	1.0	null
OA-54-FL10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284965
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.05848
BRD-K90686617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00819
BRD-K92884779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03867
CRCGN017_MCF10A.TP53.M_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2782
GSE173262_6_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K49108064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84147
BRD-K39020351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46133
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_94_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V955-0426-SM-3GAEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949394
MCF7_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153476
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245365
Thyroid cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.866
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R3RS-1326-SM-48FE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17984
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01378
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.107102
GSE116299_0_v_3_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HS695T	DepMap CRISPR Gene Dependency	1.0	2.63935
BRD-K62833556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04693
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU-DHL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09723
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861739
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6205
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36449
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-77-QQ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318897
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46864
GTEX-PWN1-0626-SM-48TDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19404
Perturb_1573_KO_Ctr9_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.33782
CRCGN017_MCF10A.WT.HP_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04995
NCIH69	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53552
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.824958
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133997
OVCAR3	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.04424
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WQUQ-0426-SM-3MJFU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01961
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cyclophosphamide_mus musculus_gpl13209_gse27422	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLIN5_OE_GSE44192_482_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.964471
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.47775
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05201
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261247
Coated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
PPARG-23326641-C3H10T1-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
LUDLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.34692
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958119
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35961
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.588
BRD-K18864235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11965
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289427
AD-58-PW17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288401
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.31606
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578237
paraventricular nucleus, cap part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60291
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.44778
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24139
GSE149035_1_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
RH-18	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60326
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.900287
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.925578
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T6-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131665
GTEX-T6MO-1726-SM-33HB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942545
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-68-KG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245016
MUTZ5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63798
rosiglitazone_homo sapiens_gpl96_gds2705	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76462
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26153
BRD-K88527653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29135
EC-98-KI28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328239
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.74607
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE129241_4_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49908787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19971
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-0.836633
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.38947
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endoplasmic reticulum to Golgi vesicle-mediated transport	GO Biological Process Annotations 2023	1.0	null
BRD-K68078571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09822
5535_NDUFA2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0751
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-15-MK46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.549642
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2912
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107673
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26308
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.2059
fat_x1.V2	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.873871
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72565671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24976
CC-18-YW57_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.575065
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93695
Perturb_6850_OE_ZNF37A_SRP273660	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.0594
GSE122101,GSE122103_0_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.30057
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150666
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.7339
BRD-K00509345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61363
RNF2	ENCODE Transcription Factor Targets	1.0	null
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.736451
Blood-myeloid progenitor	Tabula Sapiens Gene-Cell Associations	1.0	-0.169225
GSE112174_5_v_7_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein localization	GO Biological Process Annotations 2023	1.0	null
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180424
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2807
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187697
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136296
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149906
BRD-K60038276_irbesartan_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.886923
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02798
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.431
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NH-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54330070_SB 202190_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213649
BRD-K54141134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46294
GTEX-XAJ8-0826-SM-47JY6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958194
DB-56-XL71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336294
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17869
BRD-K03176945_7910663_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K39499927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21476
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866026
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-66-UB12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.507218
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75735
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-71-6725-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
golgi cisterna membrane	GO Cellular Component Annotations 2015	1.0	null
protein localization	GO Biological Process Annotations 2025	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.614
IA-80-OW42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255307
cytoplasmic vesicle part	GO Cellular Component Annotations 2015	1.0	null
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15056
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1437	GDSC Cell Line Gene Expression Profiles	1.0	1.96184
Globus pallidus, external segment	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21851
POTEE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09884
KDM5B	ENCODE Transcription Factor Targets	1.0	null
YA-44-LW45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327002
JE-04-LS32_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200803
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872152
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09105
AZD1390_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0217366
GSE235017_1_v_0_uba52_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86946907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40778
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20654
NCI-H2029	GDSC Cell Line Gene Expression Profiles	-1.0	-1.81613
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26656
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06525
Lung squamous cell carcinoma_LUSC_TCGA-66-2789-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825685
Ciliary rootlet	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.51
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
AB-34-RQ73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210064
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77244
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38907
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.86064
t60-adrenal_female_2w	MoTrPAC Rat Endurance Exercise Training	1.0	1.32048
PLOD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00258734
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3028
GSE202587_1_v_0_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.57834
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424265
PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89767_6_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18742343_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cholestasis	CTD Gene-Disease Associations	1.0	1.09047
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	1.05312
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965533
BRD-K79494396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25205
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.425
GTEX-XUZC-0426-SM-4BOPE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851964
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64744
hsa-miR-4327	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCPAP	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08042
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453884
BRD-K13681581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42519
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429462
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5WG-1626-SM-4LMKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03247
IFT27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12239
FB-33-LI31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.467945
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.3603
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.836633
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28165749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05169
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22539
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47474571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53333
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421813
HIV - Human immunodeficiency virus infection_Peripheral blood mononuclear cell_GSE2171	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.88974
BRD-K76908866_HY-11008_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44325
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85965
Retrosplenial region	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.567
BRD-K82504878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73817
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91167
MCF7_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0284865
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCI-15A	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.05263
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TC-59-QN21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20488
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09643
GSE95771_0_v_2_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
18535662-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23833
BRD-A84923154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04106
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCF7_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145229
CMK115	CCLE Cell Line Gene CNV Profiles	1.0	1.68612
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018383
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1120_KD_CCND3_SRP325057	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.93505
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85997
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.496028
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1395	CCLE Cell Line Gene Expression Profiles	1.0	2.19682
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.743
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224453
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
RT4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Tranilast_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0148538
GSE157894_2_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.20996
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.04352
BRD-K48092898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17829
posterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.975135
TAS2R5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37984
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21942
myricetin-1334	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ3S-1526-SM-4BOOC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35294
AA-52-JS03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325663
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294653
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890387
IFT25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53884
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.847035
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146646
Microbody membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.8
M14	BioGPS Cell Line Gene Expression Profiles	1.0	0.955241
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7141_RBBP5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.530535
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23868
GD-59-OG21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378722
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01456
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.72939
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7612
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25045770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48178
BRD-A19037878_trichostatin A_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K49419779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61802
Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11487
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70315531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23949
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00907
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1739
BRD-K77175907_DM-100_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27635
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275468
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PDLIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11498
A549_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0302614
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74402642_Chemistry 2804_NOMO1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FAM204A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06096
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272673
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954587
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.72327
salivary gland	HPA Tissue Gene Expression Profiles	1.0	2.23326
Lung squamous cell carcinoma_LUSC_TCGA-18-3414-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF236	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22105
MCF7_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168581
CTCF-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109329
GSE233183,GSE233187_3_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958362
ARID3A	ENCODE Transcription Factor Targets	1.0	null
MCF7_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191368
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44519
PPP1R16A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14925
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.74758
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936229
BRD-K66876909_PZ0014_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.32626
5811_NRF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.714792
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.838011
USF1	ENCODE Transcription Factor Targets	1.0	null
HCC1500	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39948
BRD-K04441230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64083
MAF_01_165	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	9.50012
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	1.70814
SNU761	CCLE Cell Line Gene Expression Profiles	-1.0	-2.6568
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45042
20937356-TableS1	GeneSigDB Published Gene Signatures	1.0	null
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42882
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.80401
KASUMI1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77882
CRCGN015_MCF10A_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42587
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FF-34-KW62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.821636
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of PHyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01875
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.879826
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-PLZ6-0526-SM-3P61C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891263
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845455
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27743
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A75409952_wortmannin_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2807
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TCCSUP	GDSC Cell Line Gene Expression Profiles	-1.0	-1.41989
TE6	CCLE Cell Line Gene CNV Profiles	1.0	1.5628
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LNZ308	Achilles Cell Line Gene Essentiality Profiles	1.0	1.01338
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22207
BRD-K68379391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35141
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.647414
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.355247
Microneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
GTEX-WFG7-0426-SM-4LMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09072
BRD-A02481876_Importazole_U937_6.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84197
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20629
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.15403
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.2733
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1-17558387-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AD-65-WK61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222819
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.949751
LCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570115
OAW28	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84441
Folic acid_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0263663
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18061
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124967
MCF7_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131113
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.622222
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A50Z-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38972344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6112
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.10345
K562_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01586
EIPA	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.67
GSE225218_8_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74029109_2-(4-(4-chlorophenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)ethanol wh-gc-round5-17_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DUSP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063975
U937	CCLE Cell Line Gene CNV Profiles	1.0	1.5819
BRD-K30937829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64965
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38958
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.675
BRD-A62025033_temsirolimus [CI779]_NOMO1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Divalproex Sodium_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149286
BRD-K90360779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2202
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MB-49-LL22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267572
GINS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42416
BRD-K60623809_SU11652_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F2_KD_GDS4094_447_mouse_Mammary tumors (Myc-induced)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8394
PC-87-OG75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.457454
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50338
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7977
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05144
BRD-K82217056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29447
Necrosis	CTD Gene-Disease Associations	1.0	2.02865
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51672
FARAGE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147426
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.96045
A549_AT9283_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01063
COPII vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.613
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228014
GTEX-XK95-1026-SM-4GIDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07598
ITGAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520531
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2029
GTEX-R55E-1326-SM-48FCR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48398
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07946
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE3583	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.931169
GSE229102_1_v_0_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16149
GTEX-WFJO-2026-SM-4LVM3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01639
GSE140651,GSE140653_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.311744
RGS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551813
bounding membrane of organelle	GO Cellular Component Annotations 2023	1.0	null
BRD-K92701606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12636
NCIH2172	CCLE Cell Line Gene CNV Profiles	1.0	1.75889
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1264
BRD-K79090631_CGP-60474_HEPG2_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.622347
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.56188
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.4426
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18012
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9250_TRAPPC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14922
Lung squamous cell carcinoma_LUSC_TCGA-85-A4JC-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04688
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05315
GSK3B_knockdown_208_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.29782
ventromedial hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.878873
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K47228832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86256
BRD-K04147413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81304
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.95747
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.66965
DF-70-CD57_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309168
MXI1	ENCODE Transcription Factor Targets	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.844
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12204
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.601
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KLE	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52656
biological_process	GO Biological Process Annotations 2015	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3808
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dactinomycin_mus musculus_gpl1261_wild type_gds2456	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE127790_6_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92999
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896992
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAB3A_KO_GDS2483_701_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15364_KO_Mef2c/Mef2d_SRP064307	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
AB-64-ZX70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2185
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40468
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00746
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95846
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JJN3	Achilles Cell Line Gene Essentiality Profiles	1.0	1.16873
BRD-K17743313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58103
GORASP1	Pathway Commons Protein-Protein Interactions	1.0	null
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP50-MEL-B	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.21634
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01796
esophagus_5c	HPA Tissue Sample Gene Expression Profiles	1.0	0.897349
COPI-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.731
GABP-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
corticoid layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11119
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16492
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Olfactory tubercle, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02624
NCI-H520 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.192
496100572_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04925
BRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24889
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50119
Prostate adenocarcinoma_PRAD_TCGA-CH-5767-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09663164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30123
hesperetin-1947	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
laterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50223
periventricular stratum of r1BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13417
CDK10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670251
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AURKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.007343
BRD-K39176069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21504
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1184	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57667
MYBL2	ENCODE Transcription Factor Targets	1.0	null
SYMPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75388
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.79517
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	1.63937
MYC	ENCODE Transcription Factor Targets	1.0	null
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205659
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2304
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K39584933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94728
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.52546
transport	GO Biological Process Annotations 2015	1.0	null
BRD-K90133770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67918
MCF7	CCLE Cell Line Gene CNV Profiles	1.0	1.92576
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17775
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WI4N-2726-SM-3LK7Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28613
BRD-K21384875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50782
BRD-K29905972_S1005_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74325
MCF7_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00811433
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836613
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40999
16012520-Table2	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
KP-4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.64735
Perturb_13439_KD_Myb_SRP119047	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alcohol poisoning_Pancreas_GSE3311	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.624365
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180753
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178033
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7	DepMap CRISPR Gene Dependency	1.0	2.90627
GK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058732
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364644
BRD-K04407772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11365
NCI-H378	GDSC Cell Line Gene Expression Profiles	-1.0	-1.64213
BRD-K09250623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38256
Aspirin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0335797
PAFAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37732
K562_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159412
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983428
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MS4A10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519404
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31298
PMC11242342-jcav15p4513s1.pdf-29-ARID5B_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07662722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.95092
GTEX-P4PP-0126-SM-3LK69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68779
QB-99-OU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257083
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24493
BRD-K17140735_-666_NCIH508_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CEACAM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00655864
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19803
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.997361
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.946479
NCI-SNU-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.64
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.29502
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89692698_-666_PL21_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286658
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1392
4270_KANSL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.570906
BRD-K48276655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19842
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252236
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.793335
estradiol_homo sapiens_gpl6102_gse11567	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9473_U2AF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.35691
SKMEL5	BioGPS Cell Line Gene Expression Profiles	1.0	1.5886
subbrachial nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.1143
Prostate adenocarcinoma_PRAD_TCGA-G9-6366-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCA1_Knock-in_GDS1756_234_mouse_Forebrain tissue - 12 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
JHH6	CCLE Cell Line Gene Expression Profiles	-1.0	-2.90389
DA-07-LL18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211721
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3138
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219794
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SB-74-OD45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211735
golgi apparatus	GO Cellular Component Annotations 2015	1.0	null
BRD-K77541177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89228
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC2A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516105
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.52639
AE-22-QI24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257184
MB-46-BT89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229246
A549_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137452
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
K562_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180363
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HY-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WB-54-WD35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263367
shown	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-2.09998
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40549
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.371572
BRD-K81418486_vorinostat_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU466	CCLE Cell Line Gene Expression Profiles	1.0	1.64637
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101546_2_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane coat	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
increased circulating iron level	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19199
GTEX-S33H-0826-SM-4AD5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2157
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UJHI-1526-SM-3DB99	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37194
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.97755
19843711-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GA-04-JM33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436711
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842123
ROS50	DepMap CRISPR Gene Dependency	1.0	2.0814
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
especially	GeneRIF Biological Term Annotations	1.0	null
FD-59-TC81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253242
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K27476515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08695
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36190163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2654
Malignant mesothelioma of pleura_Pleura_GSE2549	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.21646
MPZL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00433394
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95603
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17942
MAPK1_knockdown_45_GSE12291	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.91481
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9484_KO_Tcf7/Lef1_SRP251706	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.12982
COPI vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.775
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FBXL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30364
BRD-K01240438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35686
BRD-K02822062_CT-200783_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24425
DA-10-GX45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302469
BRD-K97052218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72284
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47
GSE87615_1_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
PHOX2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17593
dexamethasone_mus musculus_gpl339_gds2314	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77961
HCT116	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.33013
endoplasmic reticulum membrane	GO Cellular Component Annotations 2023	1.0	null
GTEX-OIZH-2626-SM-2HMJM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11248
RPS3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01619
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897928
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.511
BRD-K72351789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.174
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Tofacitinib (citrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0296508
PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S2-HSF1_CanSig_Genes-HSF1-CanSig_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47326075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14698
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165701
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.961166
9545_UBR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515199
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
r9 part of spinal trigeminal nucleus, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56496
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51791390_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Postsubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09355
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56713
BRD-K26048285_HTS 13363_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0475
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866026
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.217
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Locus ceruleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88913
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829071
Coated membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MCF7_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205996
Lung squamous cell carcinoma_LUSC_TCGA-37-3789-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31992830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63535
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.4596
A549_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167348
BBC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00597565
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66X-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMIM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16946
BRD-K28774715_T6094031_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CCR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646323
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
posterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05498
BRD-K85271599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08351
Intra-Golgi and retrograde Golgi-to-ER traffic	Reactome Pathways 2024	1.0	null
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.59645
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22495
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-POYW-1326-SM-48TCG	GTEx Tissue Sample Gene Expression Profiles	1.0	3.02121
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37448
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.893831
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03236
Capmatinib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0165787
prostate gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160817_3_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03513
Tumor Thrombus	DisGeNET Gene-Phenotype Associations	1.0	null
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A52530684_DOXORUBICIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FB-85-ND09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48244
BRD-K53757555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05318
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.50585
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91885
BRD-K68594161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44317
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840677
TE10	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.53214
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84791
HMCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526002
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197895
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
HSG	BioGPS Cell Line Gene Expression Profiles	1.0	0.968679
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.45312
18614019-TableS4d	GeneSigDB Published Gene Signatures	1.0	null
Peripheral_Blood_Mononuclear_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.839738
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.00305
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.496
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6723
Infertility, Male	CTD Gene-Disease Associations	1.0	1.32637
Mesothelioma_MESO_TCGA-SC-A6LP-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Demeclocycline_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00617706
A549_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222891
GSE226249_2_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-92-TW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.672203
mantle zone of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12495
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FA-65-UA27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.432332
BRD-K25731886_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6UA-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33023
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_2-up-regulated_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1568	CCLE Cell Line Gene Expression Profiles	1.0	1.66256
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34974135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25368
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.743594
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.62287
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE243491_1_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MET_knockdown_254_GSE38343	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.09492
shell of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32647
A549_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111147
HCC78	DepMap CRISPR Gene Dependency	1.0	2.39577
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177984
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EC-01A-21R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.18354
lower basal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10386
Perturb_10872_KO_fatp2_SRP229353	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.82293
BRD-K93611325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55107
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8328
PFKL_OE_GDS1079_201_mouse_myoblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.08797
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RSV_48Hour_22398282_GSE32138	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.66681
BRD-K13094524_PFI-1_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80633
CTCF_GM12865_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LD-48-CY61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204707
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.943332
Neoplasms	CTD Gene-Disease Associations	1.0	1.40288
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574395
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.94611
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1571
MA-58-RR04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499418
USF	MotifMap Predicted Transcription Factor Targets	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.61389
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.935
BRD-K96733881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29692
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913594
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46362
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141686
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00008
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SE-76-JI27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348222
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.895894
TUHR4TKB	DepMap CRISPR Gene Dependency	1.0	2.08178
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8334-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47545
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58101
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02493
GSE144481,GSE144483_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.623
periventricular stratum of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49327
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84595254_Strophanthidin_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Asparagine N-linked glycosylation	Reactome Pathways 2024	1.0	null
LE-80-BM08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223308
MCF7_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139335
BRD-K44833533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24219
inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11999
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PAM complex, Tim23 associated import motor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.782
preopto-hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00828
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
LHX1_KO_GDS2748_298_mouse_embryonic renal vesicles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A32161980_H-5832_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.920138
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842051
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83984
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LAMA84	Achilles Cell Line Gene Essentiality Profiles	1.0	1.78425
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Scissor_AND_Tumor_NOT_Prognosis_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
Ventral posteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29212
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K80198069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3363
BRD-K53896147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52358
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051147
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD4-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38283
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64440589_SEW 05685_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16136897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36902
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877205
BRD-K04853698_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ARL8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3587
ND-54-NO97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.384282
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FCGR2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513512
BRD-K12886565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02139
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190255
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
HD-19-IW09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.546974
A549_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197131
K562_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295064
ID-90-NM43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34122
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.12975
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432429
K562_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199429
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.665973
BRD-K16943897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4414
BRD-K46120925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04449
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039584
COPII-coated ER to Golgi transport vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17818
kidney	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-1526-SM-4AT6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969683
ESC_J1_UP_EARLY.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
PI4KA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00507189
BRD-K15380626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05639
Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K16279128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4544
Venom duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.801
endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.688529
Sarcoma_SARC_TCGA-DX-A23U-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TF-77-DW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222735
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146982_3_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.957596
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.033588
ventrolateral part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48065
MCF7_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231805
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77922263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33042
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34546
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.648414
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-0.836633
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33058
BRD-K40175214_torin-1_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.50221
r8 part of spinal trigeminal nucleus, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08895
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09061
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60255752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14688
EBF1	ENCODE Transcription Factor Targets	1.0	null
OCUG1	DepMap CRISPR Gene Dependency	1.0	3.51507
BRD-K10812033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24846
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314563
BRD-K41160163_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129226
Vesicle coat	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
lateral trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2283
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2655
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41885
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.4986
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281351
Perturb_12854_KD_Pdx1_SRP149543	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	77.8625
A549_Alisertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165419
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adenoma_Colon_GSE4183	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.8126
GSE151782_1_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25103635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20397
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.928965
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-Unnamed_1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42992
ATAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.729
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian Diseases	CTD Gene-Disease Associations	1.0	1.09332
GTEX-R55G-0326-SM-48FDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901785
FF-22-NB12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.431601
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.097812
STK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523194
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.31591
DE-62-FI29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391396
PHOX2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70139
BRD-K00974016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35204
BRD-K73355908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2526
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907365
SFMBT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4327
BRD-K92059157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81986
PPID	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055564
K562_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238982
periventricular stratum of r3Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58194
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-769-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.957663
GATA1_G1E-ER4_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ITPKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546638
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
BE-38-UW72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472858
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.836633
NRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83667863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28271
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XA-12-UL84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.604797
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7709
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150375
XC-88-ZM66_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261661
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993318
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158285_0_v_1_ddx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K16826019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09147
KMS28BM	CCLE Cell Line Gene Expression Profiles	1.0	1.54943
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QVUS-0626-SM-447CC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09224
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6832
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240953
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
BRD-K64642496_-666_SKMEL28_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136985
BRD-K40018788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46477
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11287
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	2.03495
786O_KIDNEY	CCLE Cell Line Proteomics	1.0	2.27715
19843711-TableS2	GeneSigDB Published Gene Signatures	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
copi-coated vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K91349888_arg-a1-22 BRD-K91349888_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.18948
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04627
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66735533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13019
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3546
GTEX-P4PP-1626-SM-2HMJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0185
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43779
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RPMI 2650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.9035
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02003
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2067
GSE89767_7_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SGI-1776	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
PPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589912
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12188
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80L-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309823
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33034
BRD-A75409952_wortmannin_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4208652-phy2-2-e12047.pdf-7-SCMH1_SCMH1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9675280-12950_2022_317_MOESM3_ESM.xlsx-siPAD2_LPS_vs_siCON_LPS-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
anteroventral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06805
GORASP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K80725632_EI-232_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38264
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.680514
MCF7_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129599
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A21858158_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K16472144_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GOLD	InterPro Predicted Protein Domain Annotations	1.0	null
MCF7_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116631
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW1783	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.81784
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835895
BRD-K67566344_KU-0063794_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCDC22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00883
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09499853_KU 0060648 trihydrochloride_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M9-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HD-51-KD29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334322
Suprageniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9966
Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.26548
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.87922
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17533
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.17918
GTEX-S3XE-1726-SM-3K2AM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09612
BRD-A97198094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33288
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72414522_AZD-5438_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K40841951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95471
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447291
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OB-15-UL37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.572027
vesicle coat	GO Cellular Component Annotations 2025	1.0	null
A549_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153938
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XOTO-0126-SM-4B66N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0061
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291232
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_in_HEK_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_HEK293DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4395-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A695-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
DE-48-HZ49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.47657
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80513
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
progesterone_mus musculus_gpl4277_gse5783	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anethole trithione_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021723
BRD-K56332068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39586
intracellular protein transport	GO Biological Process Annotations 2023	1.0	null
Doxycycline (monohydrate)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0146621
A549_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146866
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3719
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.835425
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.99856
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	8.03204
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.40372
BRD-K14258088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29827
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41985
BRD-K63800697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21162
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17596
Muscular Dystrophy_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE3252	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.46816
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.88363
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210476_9_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47776393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16028
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12267335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76522
inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1983
DHX58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5791
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Perturb_2035_KO_Pth1r_SRP341470	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.56932
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CDK8_knockdown_88_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.73735
G6PC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551571
5016_MFAP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16857
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.2912
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.970894
BRD-K79779816_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
18535662-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
GATA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00356159
BRD-K92428232_HY-50877_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.43459
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.26662
AF-80-GK24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336024
BRD-K66939340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44392
UACC62	DepMap CRISPR Gene Dependency	1.0	4.35267
BRD-A98670841_ST012030_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68202742_trichostatin A_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.480053
JHH2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.46231
BRD-K64800655_HY-11001_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_12848_KO_Kdm4a_SRP192379	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.88449
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
Hyperplasia	CTD Gene-Disease Associations	1.0	1.67654
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.07022
KA-60-LC14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226389
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K35708212_Strophantine octahydrate_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Secondary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lidocaine (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00976297
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2836
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A52650764_Ingenol 3, 20-dibenzoate_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Abemaciclib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0209104
membrane coat	GO Cellular Component Annotations 2015	1.0	null
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27391
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A96799240_GR-109_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167617
vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
APOB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536131
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.41341
MCF7_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237377
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85465
BRD-K48611791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07382
Perturb_5052_KO_Ring1/Rnf2_SRP078684	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.70601
TRIM27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11592
GMPPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646877
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.898181
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.44763
Simotinib_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0106786
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0126-SM-3NM95	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989325
copi vesicle coat	GO Cellular Component Annotations 2015	1.0	null
BRD-K39422601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1873
CCT241533	DeepCoverMOA Drug Mechanisms of Action	1.0	0.54
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01842
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7413-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02708799_GSK-1059615_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864286
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.949154
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23747
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92301463_-666_NOMO1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1236
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72519622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68709
BRD-A80705936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35162
CTCF_GM12868_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53844
GTEX-T5JC-1726-SM-4DM6U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02015
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.923438
BRD-K14181473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38544
ALEXANDERCELLS	CCLE Cell Line Gene CNV Profiles	1.0	1.34851
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40226
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.947123
IZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12531
Metabolism of proteins	Reactome Pathways 2024	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
HMEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.8727
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
HF-91-IU60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201325
BRD-K08438266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17254
Perturb_14159_KO_UTX_SRP399588	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO678	CCLE Cell Line Gene Expression Profiles	-1.0	-3.05428
CRCGN015_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40532
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145481
YRDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00448914
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33186
GSE180200,GSE180201_15_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AD-86-OB87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.404134
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09215
BRD-K34274486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51444
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6811834-sby183_suppl_supplementary_data_set_1.xls-ZNF804A_DEX_FDR_0_01-Gene_Symbol_ZNF804A	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175541
JMSU1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46477
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17638893-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC16A10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523842
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.986629
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.86736
BRD-A21877498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41964
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304736
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.601006
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16973
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280478
GTEX-U412-0426-SM-3DB9O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991193
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
putamen, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.90809
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.841269
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11046
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.66094
19605494-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K12986105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55293
UBE2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03376
BRD-K03352392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38098
GSE144481,GSE144483_0_v_3_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837076
GTEX-U8T8-0126-SM-3DB94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12526
BRD-K84937637_A-275_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF532	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88404
GSE233183,GSE233187_2_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04149
BRD-K18861610_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
coated vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48313
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95821
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.975627
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A30962679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17815
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82481
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.379788
BRD-K34343777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12695
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.976053
MCF7_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00966371
BRD-K19183365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15569
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95609758_-666_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285301
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427613
IC-18-TY61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.889128
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41299
BRD-K82754613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62737
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S7-MECOM_up_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.824218
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
aim1	GeneRIF Biological Term Annotations	1.0	null
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
BRD-K39813155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4903
OTS514_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0106931
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01662
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186572
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051015
HCC1806	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72348
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.86675
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
central part of CEl	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41158
hsa-miR-3920	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZSCAN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46442
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07881437_S1107_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00783
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18033
A549_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173002
COLO741	CCLE Cell Line Gene Expression Profiles	1.0	1.72039
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34126
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65155
medial geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31557
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042033
organelle part	GO Cellular Component Annotations 2015	1.0	null
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.810343
EXTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11525
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17521
1972_CWC22_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06031
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28771
Notochordal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.799
BRD-A47428621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06737
Nucleus of the brachium of the inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20509
BRD-K22870904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43394
AB-21-VE32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232771
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.899991
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-661	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.28003
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.560426
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03791970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24555
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218199
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34923
BRD-K92460921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3749
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
SNUC2A	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.01586
GSE198165,GSE198166_7_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1784_COPS7B_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635446
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
SNU-449	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53797
Kidney Chromophobe_KICH_TCGA-KN-8426-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CDK7_knockdown_124_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.69083
VCaP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.106
GTEX-P4QS-1026-SM-3NMCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02947
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.028777
5811_NRF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.574732
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42F-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19058
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POR_KO_GDS1349_497_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
5-Hydroxyflavone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99241
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164326
GSE218879_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NUGC3_STOMACH	CCLE Cell Line Proteomics	1.0	3.36756
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00954209_7643453_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IGFLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14095
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896665
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04594
AC-83-LN99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246558
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS12BM	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.1934
Lung adenocarcinoma_LUAD_TCGA-44-2661-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
715_AURKB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52953
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.47935
ELF1	ENCODE Transcription Factor Targets	1.0	null
16207381-Table1Sa	GeneSigDB Published Gene Signatures	1.0	null
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SPATA5L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00634679
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2567
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295748
IGR1	DepMap CRISPR Gene Dependency	1.0	3.66215
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9791
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09105
BRD-K17171256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07542
BRD-K41714444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03051
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07583
GSTM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665943
A549_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215677
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19519
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.18159
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537914
A549_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152505
BRD-K73880067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0111
A549_PFI-1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103955
A4 noradrenergic cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1144
MCF7_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129956
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315861
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37875
GTEX-S7SF-1426-SM-4AT5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14616
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209927
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22002
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NLRP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12152
miR-targeted genes in muscle cell - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258623
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292119
AT7519_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00716647
endoplasmic reticulum	GO Cellular Component Annotations 2015	1.0	null
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32522
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
salivarygland_6b	HPA Tissue Sample Gene Expression Profiles	1.0	2.05596
BRD-K87776049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28497
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12564
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.79223
A549_2-Methoxyestradiol_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137842
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16603
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1154
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202083
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.925578
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.62067
Prostate	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.92658
NRF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457559
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7404
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3403
BRD-K94109423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85028
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.966476
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.970917
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03549232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4005
BRD-K61022988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18306
COL6A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.215
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3773
BRD-K94176593_TWS119_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.08861
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164565
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A43330902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56944
BRD-K99783492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14886
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98963
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.366
7423_RPAP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.41388
Amylin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.835
BRD-K60069390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19548
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pralsetinib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0305576
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134356
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.564106
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE136340_1_v_2_darunavir_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138553
GSE135514_2_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46414
mafenide-1441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
coated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.830184
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.901858
miR-targeted genes in lymphocytes - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
AC-47-YZ27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36601
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02453
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Table_S5A_Upregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXA1-25552417-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE164463_2_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.645378
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
6708_PPWD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.576142
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4653-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
AC-50-FR41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246713
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.46008
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sox12	GeneRIF Biological Term Annotations	1.0	null
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Medial geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46566
localization	GO Biological Process Annotations 2015	1.0	null
BRD-K46195730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66391
L-428	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.46099
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22712
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21206
body of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13231
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82696
HS 38.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.902748
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7PM-0126-SM-4AD6S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81189
BRD-K40222892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02925
MCF7_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172526
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00992017
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pallidal islands of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39122
NCI-H64	GDSC Cell Line Gene Expression Profiles	-1.0	-1.82369
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NPA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.732
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44808
amygdalohippocampal transition zone, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.947559
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15174
Fetal Death	CTD Gene-Disease Associations	1.0	1.63227
EWS-26573619-CHIP-SEQ-HEK293-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52108
K562_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024059
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
8853_TFIP11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42074
PancreaticIslet	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.43039
GTEX-WL46-0126-SM-3TW8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00799
SNU61	DepMap CRISPR Gene Dependency	1.0	3.07417
Anterior amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09945
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04887706_Akti-1/2_SKMEL28_6.0_h_9.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
U266B1	CCLE Cell Line Gene CNV Profiles	1.0	1.53365
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7631-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.75876
BRD-K87140555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3796
Epstein-Barr virus copy number in lymphoblastoid cell lines	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
K562_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188412
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
superficial stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01714
BRD-K22010301_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K58408512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02693
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49863
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPIC-1626-SM-4IHKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878785
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SEC23A	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.809
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
isthmic roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05852
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213632_3_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_13_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC28A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1593
BRD-A58280226_Y27632_SKMEL28_6.0_h_4.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
BRD-K28122619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0453
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GC-54-IZ89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291336
PC-87-OG75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417588
Coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.513
Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
salivary gland	GTEx Tissue Gene Expression Profiles	1.0	1.15949
STAT5A	ENCODE Transcription Factor Targets	1.0	null
GATA1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K91370081_Anisomycin_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.830475
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05852
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.5903
orbital frontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.912385
GSE173810_4_v_6_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72891
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsomedial nucleus, terminal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24409
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.25265
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21458
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
OGFOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587287
PMC4728380-ncomms10153-s11.xlsx-M14278-SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_UP_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29577
BRD-A52893269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26573
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25798
Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF750_KD_GSE38039_696_human_HaCaT keratinocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156889
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.24088
bounding membrane of organelle	GO Cellular Component Annotations 2025	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08371
BRD-K81082552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5027
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.894966
BRD-K41814083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38251
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212376
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41192
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2482
BRD-K18518344_Digitoxigenin_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128195
PPP1R15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1927
BRD-K30491662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0135
ZM-226600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14176
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48379
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17413
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477358
BRD-K28848179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07611
r4 liminal central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21779
GSE160077,GSE160084_3_v_0_bin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30197
Rectum adenocarcinoma_READ_TCGA-EF-5830-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915533
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393814
MCF7_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014461
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09105
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85359206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11558
Postsubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16008
layer 6b of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45941
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61149
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62294866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14358
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4201
Pulmonary Edema	CTD Gene-Disease Associations	1.0	1.11501
a24	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.851
PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933521
A-CA-04-2009(H1N1)_24Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.25754
PLA2G2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00408571
RIPPLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21856
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.463049
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	1.0	1.13456
shell of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22301
BRD-K98890753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53986
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.21321
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36078
BRD-K58469385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78404
organelle organization	GO Biological Process Annotations 2025	1.0	null
TRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28884
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.509725
membrane part	GO Cellular Component Annotations 2015	1.0	null
Perturb_7149_KD_HBS1L_SRP070129	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.58347
QA-34-PH05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.486332
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.1555
COLO741	CCLE Cell Line Gene CNV Profiles	1.0	1.94506
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76351135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2198
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00802
BA-90-AA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.500528
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tissues	GeneRIF Biological Term Annotations	1.0	null
Paraventricular hypothalamic nucleus, descending division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11487
SW620	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.8634
BRD-K64001802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80924
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.849359
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159607
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XYKS-2126-SM-4E3IB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38847
CA-96-UO48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358856
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207593
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.06952
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
gfi1b_22201127_amulv_gof_mouse_gpl6246_gds4302	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.137282
BRD-A09961470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05461
BRD-K10893370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01003
MB-32-LQ97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237046
CA-48-JF51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314914
CCNT2	ENCODE Transcription Factor Targets	1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11756
lateral terminal nucleus of the accessory optic tract, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34822
BRD-K16485616_S1122_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.449734
intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A02214146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4022
SK-MES-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.779
PPFIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77346
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17322
REH	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.17386
GSE116299_6_v_1_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pectoral fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CHST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30196
A549_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151623
Endoplasmic reticulum-Golgi intermediate compartment membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
DF-75-OU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232763
hsa-miR-4253	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Transport vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A59682351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1887
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17483311-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231774
H3K27ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K68548958_-666_PL21_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.894362
KE-24-RZ94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24215
hsa-miR-3921	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
CRCGN015_MCF10A_48H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0747
Fascia dentata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
BRD-K90694955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68874
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41555
BRD-K64890080_BI-2536_LNCAP_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IB-56-JN40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492325
16288205-GeneTable3	GeneSigDB Published Gene Signatures	1.0	null
icSARS-Cov_Day1_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.41111
BRD-K64890080_BI 2536_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.561
A549_Aurora A Inhibitor I_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020033
Perturb_5333_KO_Myc/Mycn_ERP009787	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.31917
SPI1	ChEA Transcription Factor Targets	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866026
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Retrosplenial area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56625
GSE165939_2_v_1_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JARID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01833
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40375
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13584
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866026
CCDC82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61412
BRD-K50004365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12218
GTEX-OIZG-0226-SM-2TC5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91132
Perturb_14916_KO_Cd2bp2_SRP034660	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.25529
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anemia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K90826279_-666_SW620_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56120807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24846
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UD-20-ER54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248774
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.89276
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58193973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76605
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A94756469_DIGOXIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
locus coeruleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2452
Serum Albumin Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63606607_bufalin_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDCA7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98286
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016353
BRD-K73387470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49064
superficial stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31351
BRD-K14799424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36763
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SR-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.8185
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49729
GRK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00532748
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11143964-jciinsight-9-161356-s009.pdf-15-ZNF841_ZNF841	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
esophagus_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.045
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914446
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-02-XL81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.361876
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K36320220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23992
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.06222
MCF7_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013996
EFM-19	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.60658
BRD-K99545815_HY-10459_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.905774
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
K562_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163367
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135992
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-2626-SM-4AT6B	GTEx Tissue Sample Gene Expression Profiles	1.0	3.36222
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332265
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-7332-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18548
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.685117
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81418486_vorinostat_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
6797_PRPF3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10605
BRD-K13898728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93243
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.556608
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2567
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.789
K562_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145584
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6283_PHF19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.501084
Sirt1_OE_GDS2658_140_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02216
Superior olivary complex, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10583
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.451531
CF-97-KZ12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229169
Bergenin_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0173008
Bimiralisib_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134103
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205552
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61305
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.386
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.41625
TCF4	MotifMap Predicted Transcription Factor Targets	1.0	null
mRNA_KAT5_22196727	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A25883214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79494
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
TNFSF13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00453763
HOXB7-26014856-BT474-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154797
Perturb_3717_KD_IRS2_SRP375176	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.091356
GTEX-VUSG-1426-SM-3GIJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09353
BRD-K56645451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07802
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
WM1799	CCLE Cell Line Gene CNV Profiles	1.0	2.48665
BRD-K71452126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72248
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.902748
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Tucidinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164747
IZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7602
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916738
DSTYK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521205
liver	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.24532
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
highly	GeneRIF Biological Term Annotations	1.0	null
Nijmegen Breakage Syndrome	DisGeNET Gene-Disease Associations	1.0	null
H2731	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K67131822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40663
E2F6	ENCODE Transcription Factor Targets	1.0	null
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90658
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54547
6-Mercaptopurine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
Trachea	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.21343
TF-43-DT71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240574
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-30-BE85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302567
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15043
9454_TXNIP_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.819671
A549_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010408
LEF1_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250603
endoplasmic reticulum-golgi intermediate compartment membrane	GO Cellular Component Annotations 2015	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8415-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35366
BRD-K33177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0281
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_Activation - 21 days_GDS2025_727_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
EFM19	DepMap CRISPR Gene Dependency	1.0	5.08217
BRD-K39227064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37845
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5571
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209998
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H209	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47879
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.61905
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JMSU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41123
BRD-K42221274_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AB-30-CR11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352678
PMC8185471-mmc6.xlsx-up-_and_downregulated_genes-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_shared_FO_and_FC_regions_respectively_Related_to_Figure_6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211179
colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.38111
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09215
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57761
GSE114992,GSE114993_8_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCFL_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	6.44768
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132287
PMC9464213-41467_2022_33063_MOESM9_ESM.xlsx-BNC2_proteins-gene_name_BNC2	Rummagene Transcription Factor Associations 2026	1.0	null
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.975507
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
knockdown	GeneRIF Biological Term Annotations	1.0	null
CLCF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583584
SE-81-RI20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242515
hsa-miR-1237	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27215
disease	GWASdb SNP-Disease Associations	1.0	0.024876
GSE101546_2_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89558221_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
S0-EE-Y79N_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250753
A549_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132264
Leukemia, Chronic T-Cell_T lymphocyte_GSE5788	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.92862
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854739
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.3368
RCOR1	ChEA Transcription Factor Targets	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5388
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_DN-Gene_name_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DLX5_Deficiency_GDS4443_356_mouse_E10.5 embryos otic vesicle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.894051
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane region	GO Cellular Component Annotations 2015	1.0	null
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94335
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51160592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13748
BRD-K09271653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59208
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.56515
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50337
HB-75-KT12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28377
K562_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173521
BRD-K24132293_piperlongumine (HPLC)_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_1-Unnamed_0_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0388
BRD-K56411643_-666_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.60788
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.6861
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-140-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01791
BRD-K90127029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06347
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endoplasmic reticulum-Golgi intermediate compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.167
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGSF23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654346
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.74578
paraventricular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87168
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-36-XE09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231053
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58465
BRD-K53706972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17348
ZNF263	ENCODE Transcription Factor Targets	1.0	null
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97844
Ventromedial hypothalamic nucleus, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22723
Perturb_1996_KD_Sun1/Sun2_SRP354599	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.3583
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0686
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33973
BRD-K64559139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27154
A549_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155582
BRD-K77320034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64993
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
18614019-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
PRSS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57744
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.27284
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02982
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BF-94-CQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27409
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Perturb_16457_KO_CHUK_SRP229998	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CALR_KO_GDS3680_149_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IL6ST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2126
BRD-A42030853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27284
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X261-3226-SM-3NMC3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831599
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.8996
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926553
PMC11604901-13555_2024_1298_MOESM1_ESM.pdf-19-NFIA_NFIA	Rummagene Transcription Factor Associations 2026	1.0	null
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03834
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07157
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.811605
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.960419
GSE147662_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
496100491_HIP_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10598
GTEX-XOTO-2126-SM-4B64U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18626
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379105
tpx2	GeneRIF Biological Term Annotations	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-175-VII	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.34902
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Muscle-mature nk t cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.169642
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325054
endoplasmic reticulum-golgi intermediate compartment	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.54
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14434
BE-38-UW72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418498
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24602
A549_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260899
Endocrine pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.272
2502_EFTUD2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29197
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.69646
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3045_KD_Ppp1r13l_ERP023515	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.16527
BRD-K41996876_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-3922-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.864069
Lenalidomide (hemihydrate)_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0104151
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.224
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33023
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12885
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49845
layer 6a of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00752
BRD-K33005275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60326
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.986629
MON	DepMap CRISPR Gene Dependency	1.0	2.75489
A549_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202039
GTEX-UTHO-0008-SM-4JBID	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903203
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201494
BRD-K12431811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01858
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287652
BRD-K88707941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00551
cingulate gyrus, parietal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28887
KM-12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14741
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68980973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68891
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-U07805514_saracatinib_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5789
H3K4me1_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.829576
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.105
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF15_02_106	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.623
CRCGN011_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9986
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17144_OE_Xbp1_ERP110244	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.69115
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2051
BRD-K20016759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60527
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHUK_knockdown_108_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.5894
MLYCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14812
19176396-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
BRD-K63425657_NP-010914_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275743
TYK2_KD_GDS4754_158_human_JURKAT	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48349
19699293-TableS7	GeneSigDB Published Gene Signatures	1.0	null
Color agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-2326-SM-3DB96	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855482
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.842376
BRD-K82521339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53864
BRD-K61829047_7b-cis_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC257	BioGPS Cell Line Gene Expression Profiles	1.0	1.37109
r10 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.02987
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.12495
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3902
GTEX-P4PQ-1626-SM-2HMKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19039
BRD-K72381041_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218569
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.83476
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.974726
BRD-A49544621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91763
A549_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137818
GSE180200,GSE180201_12_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_87_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36945
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.470305
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.64625
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2557
GTEX-P4PQ-0626-SM-3NMCU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979593
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2856-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.988736
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23578173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02495
Ventral posterolateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80561
GTEX-T6MO-0726-SM-4DM58	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984905
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247782
dorsal subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57195
Membrane coat	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16156
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53488
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20402
A549_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01449
BRD-K97764662_3044_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K85525164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20713
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.005967
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	0.390059
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ZFX	ChEA Transcription Factor Targets	1.0	null
GSE95771_0_v_3_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158628
A549_Aurora A Inhibitor I_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157695
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Belumosudil (mesylate)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0131557
Sarcoma_SARC_TCGA-MB-A5Y8-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.23591
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.723381
BRD-K92479346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10493
GSE247764_3_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-30-SX80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225099
diethylstilbestrol_rattus norvegicus_gpl1355_copenhagen_gds2913	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vesicle coat	GO Cellular Component Annotations 2015	1.0	null
BRD-U29336476_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ8I-1526-SM-4BOOH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853592
paraventricular nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05267
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.31884
E2F1-21310950-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
BRD-A47513740_calyculin A_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A361	BioGPS Cell Line Gene Expression Profiles	1.0	1.05584
CRCGN015_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25955
BRD-K17140735_-666_U937_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25967
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159275
BRD-K33757887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0253
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.838821
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296534
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32699
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4EO-0326-SM-3P5YO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957949
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08621
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IC-80-CT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267598
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
CBS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056364
ergic1	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06326
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
Postsubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08713
Alzheimer's Disease_CNS - Brain - Hippocampus (MMHCC)_GSE1297	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.6803
diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K57080016_-666_HT29_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.956996
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.181371
GSE149366_1_v_0_sulconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17969
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01729
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-SNMC-1326-SM-2XCFK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866169
BRD-A35871558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22038
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215743
TPGS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69334
Perturb_14363_KD_SORBS2_SRP112755	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158100,GSE158101_1_v_0_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Pracinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164315
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48371
miR-targeted genes in epithelium - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78212
A549_Roxadustat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148933
RCOR1	ENCODE Transcription Factor Targets	1.0	null
t69-brown-adipose_male_8w	MoTrPAC Rat Endurance Exercise Training	1.0	1.65065
BRD-K15269548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25388
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943651
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.54068
Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Middle midgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
HCC2218	GDSC Cell Line Gene Expression Profiles	1.0	1.90029
MCF7_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152841
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06508
GTEX-U4B1-1426-SM-4DXTX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825482
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421214
BRD-K05535086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5878
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.56952
MS751	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.37271
BRD-K11437379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71015
GSE198165,GSE198166_8_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850165
BRD-K79555196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2801
STAT1_01_154	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60143
JC-63-DO70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349373
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.17648
SOX3-22085726-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
screen	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QEG4-0226-SM-2S1PY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01526
EP300	ENCODE Transcription Factor Targets	1.0	null
KNS-62	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.48808
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74826740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30792
A549_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0419829
BRD-K69840642_HDAC6 inhibitor ISOX_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.97389
BRD-K49328571_dasatinib_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.16995
ICC3	DepMap CRISPR Gene Dependency	1.0	3.06403
GTEX-RU72-0926-SM-2TF6B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900156
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0326-SM-4DXSM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08297
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cytarabine (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0289901
K562_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170902
AD-72-RI24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352603
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75842461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22956
2233_DIS3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2883
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K24132293_piperlongumine (HPLC)_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BE-38-UW72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361301
MBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32445
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19179
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1264
OVCAR5	DepMap CRISPR Gene Dependency	1.0	2.00124
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE68156_0_v_1_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SW948_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.09048
COL9A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20408
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55911
GTEX-N7MT-0326-SM-48TDP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39741
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.612
SLCO1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495691
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37152
BRD-K88573743_A443654_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Endoplasmic reticulum-Golgi intermediate compartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC-812	GDSC Cell Line Gene Expression Profiles	1.0	2.62136
BRD-K23841751_HTS 10859_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Posaconazole_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204256
17683608-TableS3	GeneSigDB Published Gene Signatures	1.0	null
EX229_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0312737
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7631_SACM1L_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22729
SP1	ENCODE Transcription Factor Targets	1.0	null
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866026
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.42945
hsa-miR-188-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
A549_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133515
BRD-A34806832_Proscillaridin A_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
IGF2R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73669
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.145
Kidney Chromophobe_KICH_TCGA-KN-8428-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013075
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOLT-13	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.43537
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30729
Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-CI-6624-01C-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40095
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Esophageal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
XC-13-LW13_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230276
SMAD3-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228992_0_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Anorexia	CTD Gene-Disease Associations	1.0	1.06588
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65794
Cloned cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00731
CD177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12359
HEC1B	DepMap CRISPR Gene Dependency	1.0	2.46296
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25922
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.304508
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09900382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63458
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22173206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23731
Presubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05923
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.1862
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.06277
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
tiotropium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12992
GTEX-WI4N-1026-SM-3LK7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29718
GDF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95482
BRD-K55749438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29582
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8906867-pbio.3001569.s011.xlsx-All_genes_up_SupT1_XBP1s_ATF6-S7_Data_List_of_all_genes_that_were_upregulated_in_SupT1DAX_cells_for_XBP1s_ATF6_vs_Basal_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CM-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81418486_vorinostat_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51015
BRD-K13646352_PKC-412_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
HH	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00026
BRD-K86746660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58426
BRD-K17674993_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34076
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.331927
GTEX-RN64-1026-SM-48FDX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98683
ZEB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
NCIH2122	CCLE Cell Line Gene CNV Profiles	1.0	1.51316
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199686
JHH4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22881
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845626
NCIH1092	CCLE Cell Line Gene Expression Profiles	-1.0	-1.82115
GTEX-U8XE-0326-SM-3DB8P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896488
BRD-K46373671_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X8HC-0126-SM-4E3JW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16908
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11786
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAN1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4559
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HH	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46911
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138953
UACC257	CCLE Cell Line Gene Expression Profiles	1.0	1.49816
BRD-K32802965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93516
BRD-K93260425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65608
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.71047
KE-41-JG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244939
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00337364
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16180117_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.472
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCFL	ENCODE Transcription Factor Targets	1.0	null
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
DD-74-PJ26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.6554
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09398
BRD-A50837272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26598
MCF7_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143087
Golgi organization	GO Biological Process Annotations 2023	1.0	null
BRD-K87080069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21062
RERFGC1B	DepMap CRISPR Gene Dependency	1.0	2.07868
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.974897
golgi-associated vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2914
MCF7_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119448
LTBR_INHIBITION - 35 Day_GDS2005_732_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415209
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Simotinib_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0126316
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124802
Colorectaladenocarcinoma	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.11353
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35701
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39082
r7 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08527
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57962
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876009
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
golgi-associated vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ED-35-EX82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348436
MCF7_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155448
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27854
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25007
BRD-K21680192_mitoxantrone_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.054
TTC642	DepMap CRISPR Gene Dependency	1.0	10.0512
BRD-K18268126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68532
BRD-K99818283_PIK-90_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231942
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.34982
GTEX-XOTO-0726-SM-4B659	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929699
BRD-K51572611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2817
Hypertrophy	CTD Gene-Disease Associations	1.0	2.0356
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903729
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76679
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0126-SM-2XCD5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965573
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69093885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18416
Perturb_5335_KO_Myc/Mycn_ERP009787	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.90573
ZR7530	CCLE Cell Line Gene Expression Profiles	1.0	1.3804
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32758
CAPAN-1	GDSC Cell Line Gene Expression Profiles	1.0	1.57942
BRD-K14695590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29822
BRD-K87737963_CYT387_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CAPAN-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.29498
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5914
HIV - Human immunodeficiency virus infection_T lymphocyte_GSE6740	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.6194
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
BRD-K88590066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18468
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00888
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.6096
E2F4-21247883-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Resveratrol_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119358
A549_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111551
Perturb_15590_KD_TBX5_SRP355992	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.1107
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9757
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.98542
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.62053
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Ruxolitinib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014548
GSE160817_2_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07615
BRD-K64642496_-666_JHUEM2_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Spleen-erythrocyte	Tabula Sapiens Gene-Cell Associations	1.0	-0.169642
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85901
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Congenital Abnormalities	CTD Gene-Disease Associations	1.0	1.29533
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.23233
Fibrosis	CTD Gene-Disease Associations	1.0	1.05757
BRD-K53274037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30817
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.3753
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.843011
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.954314
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gallic acid_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0267476
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828931
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-0008-SM-4E3K4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956869
BRD-K63970901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38304
BRD-K17140735_-666_AGS_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324718
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
EC-98-YS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227048
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9314667-Table_1.xlsx-Regulons-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COPI vesicle coat	GO Cellular Component Annotations 2025	1.0	null
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55592
MCF7_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111093
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257369
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2722023__F4	PFOCR Pathway Figure Associations 2024	1.0	null
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.610769
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YF-00-IN39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312978
BRD-K09078201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16207
KCNE4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547713
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A28318179_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K46428124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88967
Perturb_11101_KO_Ern1_SRP110147	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.40465
GTEX-SN8G-0126-SM-32PLI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00429
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.7363
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_G007-LK_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147083
GTEX-PLZ6-1326-SM-3NB24	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981531
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.889347
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.907528
Inflammation	CTD Gene-Disease Associations	1.0	1.60944
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85584
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_8-ILL1_T_Cells_FOXP3_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
JHUEM1	DepMap CRISPR Gene Dependency	1.0	2.51801
L33	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.0526
TIA1_KO_GSE54418_264_mouse_cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K70549064_EI-156_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
rosiglitazone_mus musculus_gpl1261_control_gds4036	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.886056
IKBKG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33119
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130399
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0428
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44651
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HOS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DD-54-MA35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211055
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A5W6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
BRD-K40228218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06863
A549_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144117
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZI-1426-SM-3NB1T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869852
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r1BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15249
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09105
RAD21	ENCODE Transcription Factor Targets	1.0	null
SNU283	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77626
6801_PRPF4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01654
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989348
BRD-A76941896_Doxorubicin hydrochloride_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endoplasmic reticulum-golgi intermediate compartment	GO Cellular Component Annotations 2015	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.485
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174612
GTEX-QDVN-2026-SM-3GAEP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856726
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06664
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JT-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.16839
HEC-1-B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
HBL-100 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.867
NCC021	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.90601
GTEX-S341-1226-SM-4AD5S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832071
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus of the inferior collicular brachium, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06383
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3844
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54121
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146949_1_v_0_hemgn_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.75348
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261718
macromolecule localization	GO Biological Process Annotations 2015	1.0	null
NCCSTCK140	CCLE Cell Line Gene Expression Profiles	1.0	1.39736
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08876
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.783354
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.953431
PMC5113908-pone.0166185.s004.xlsx-Supp_1-Supplementary_Table_1_mRNA_expression_correlates_with_STAT3_phosphorylation_for_1279_genes_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.05509
E2F1	ChEA Transcription Factor Targets	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16592_KO_Trp53/Brca1_SRP186281	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.40921
RMC-6236_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0165046
r3 liminal central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58194
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.68006
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230824
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07829
A549_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152647
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336964
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GA-43-FL03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34009
CPT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547078
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06781
Brain Lower Grade Glioma_LGG_TCGA-P5-A72Z-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-M86331534_BJM-ctd2-9_COV644_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5665
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1634
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02994
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.52994
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.67385
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.30283
GSE156033_1_v_2_sparc_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW1271	CCLE Cell Line Gene CNV Profiles	1.0	1.47476
BRD-K49671696_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HSD17B8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519653
BRD-K85015012_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1981
BRD-K28296557_Akt inhibitor IV_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79304
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.72743
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A01403444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09756
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1446
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39213
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHWD-1826-SM-3LK6I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983688
Seizures	CTD Gene-Disease Associations	1.0	1.29688
SGF29	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0068522
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8104
K562_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146532
Brivudine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0286658
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.01994
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350641
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COPI-dependent Golgi-to-ER retrograde traffic	Reactome Pathways 2024	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
AD-72-RI24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522927
cis-Golgi network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.056
BRD-A64523751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44462
GTEX-RVPV-1226-SM-2TF73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08793
GSE119564_2_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552295
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FD-48-HZ39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25336
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1082
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K70254692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09742
QA-34-PH05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317402
BRD-K24946605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37873
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.851478
A549_Danusertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120157
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
Perturb_9740_KO_Kcnj11_SRP279345	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.10905
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K54024474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39574
increases	GeneRIF Biological Term Annotations	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22118
GTEX-S4Q7-0626-SM-4AD5M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936527
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04575
BRD-K19266588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33786
A549_Bosutinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179114
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.947713
BRD-A82371568_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Microglial cell_Brain_Human	CellMarker Gene-Cell Type Associations	1.0	null
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69232
5-8F cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.237
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964738
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TIA1_KO_GSE54418_260_mouse_cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
UMUC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36847
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179918
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-00-YH62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215754
outer CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18001
GSE162276_5_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4541
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BB-86-BE39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393134
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146224
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2759
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4329	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9048
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712001
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56916066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29842
KDM4A	ENCODE Transcription Factor Targets	1.0	null
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39422
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36764343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17469
GSE202310_1_v_0_ube3d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.71072
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UC-80-UO92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226992
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UQCR10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36511
TUR	GDSC Cell Line Gene Expression Profiles	1.0	2.12932
MAZ	ENCODE Transcription Factor Targets	1.0	null
BRD-A75409952_wortmannin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K36me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EC-47-EO60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.428481
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y6-01A-21R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
MCF7_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014634
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848298
SK-OV-3	GDSC Cell Line Gene Expression Profiles	-1.0	-2.03549
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78048
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06234
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_0Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.32337
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12872
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983311
SA-53-XG95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264119
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.095398
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.806803
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-75-YG01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200764
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_DN-Ensemble_gene_ID_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162276_2_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-YNU4_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208003
A549_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023749
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A30083233_NP-007374_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-1226-SM-48FDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43369
GSE183271_5_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-83-BX08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401063
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139966_4_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_424_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7886351-elife-65905-supp3.xlsx-Supplementary_file_3a-MYB_IP-MS_protein_lists_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06395
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HD-MY-Z	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52784
BRD-M08470251_Pyrvinium pamoate_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IA-27-CK10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233146
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93823
BRD-K00615600_AG14361_NOMO1_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
BRD-K00615600_AG14361_COV644_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19220233_JNK-9L_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
HMGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98031
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11678
6793_PRPF31_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06967
protein transport	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80325
COPII-coated ER to Golgi transport vesicle	GO Cellular Component Annotations 2023	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17434
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dorsomedial nucleus of the hypothalamus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12495
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9146
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.73635
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190316,GSE190324_10_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_5_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.659
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE152441,GSE152442_6_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201135
JcP contribution to LTL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41885
r3 part of spinal trigeminal sensory column, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29115
isoniazid-1399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154168
BRD-K96133500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05533
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54898
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61627
GSE197564,GSE198513_2_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fluvoxamine (maleate)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0217306
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0596
S0-EE-Y6WJ_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396012
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.479097
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54589
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28645
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.871014
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014075
BRD-K77814566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08887
GSE143662_3_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC2820517-pcbi.1000671.s006.txt--ZNF449_ZNF449	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
seeding	GeneRIF Biological Term Annotations	1.0	null
A549_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019119
OPLAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65888
A549_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236069
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OCUB-M	GDSC Cell Line Gene Expression Profiles	1.0	1.78011
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WK11-0926-SM-3NMAU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03841
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
19036130-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
SARS-BatSRBD_Day1_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.80661
TF1	DepMap CRISPR Gene Dependency	1.0	5.51314
Perturb_1694_KD_Spi1_SRP280028	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Perturb_10743_KO_Pparg_SRP289705	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.81221
BRD-K43431234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41187
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85584
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83455
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.32061
BRD-A39996500_radicicol_BT20_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I0-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4632-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386986
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
A549_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148747
3871_HNRNPL_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.797127
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.584991
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217895
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K26720280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07596
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112013
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90311
olfactory tubercle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06491
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28382
superficial stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61338
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16107
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
claustrum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.946825
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4991
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207619
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.826796
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66887
Peroxisomal importomer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
Pallidum, dorsal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24739
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
17660535-TableS4b	GeneSigDB Published Gene Signatures	1.0	null
POLRMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66789
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DL-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895998
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1299
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cyclophosphamide_mus musculus_gpl13209_gds4004	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
639-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.8106
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449394
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845424
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE231524,GSE231526_0_v_1_dusp6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.400569
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03365
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.66393
BRD-K39342915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53009
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54573313_NP-004007_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163118
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05626
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
8557_STX5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02015
BRD-K56196992_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144635
Twist2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8894
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327583
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSTM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00715629
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_0_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K55852567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09576
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.871558
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7882
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-Q2AH-0926-SM-48TZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01226
GTEX-SIU7-0926-SM-4BRX1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940849
Riluzole hydrochloride_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240641
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60587793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12298
PHF8	ENCODE Transcription Factor Targets	1.0	null
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Chordoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.8
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193592
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97121
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.635457
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.776424
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0511
GSE195568_1_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05114711_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10709143-41556_2023_1271_MOESM10_ESM.xls-Up_hPSC_PAX7-Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
genomewide	GeneRIF Biological Term Annotations	1.0	null
A549_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0112983
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50045638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79671
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lipoic acid_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0259384
GTEX-RVPV-0526-SM-47JYL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.53748
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.905148
VA-92-QP54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.620957
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.73434
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2218	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.97563
GSE114992,GSE114993_8_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-1326-SM-48FDO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973364
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
K562_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267512
GTEX-XUZC-0126-SM-4BOO6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949174
BRD-K21680192_Mitoxantrone dihydrochloride_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09105
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BE-17-CS60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259578
SOX2	ChEA Transcription Factor Targets	1.0	null
BRD-K85664064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43742
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15291808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75198
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.841269
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31735
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
KDM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09639
gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07759
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02774
GTEX-X5EB-2226-SM-46MW4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49892
SKHEP1	DepMap CRISPR Gene Dependency	1.0	2.84888
GTEX-OXRN-1726-SM-3NM9B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03735
GSE248874_1_v_0_pcdh9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.970402
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Muscle-cd4-positive, alpha-beta t cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.168391
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.921561
nes	HPA Cell Line Gene Expression Profiles	-1.0	-0.943884
Lung squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657115
DA-59-ZD74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299215
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08891
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11255
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vitamin c_homo sapiens_gpl6884_gse16590	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27391
MCF7_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017798
MCF7_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183738
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.9905
Diammonium Glycyrrhizinate_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134034
Sarcoma	CTD Gene-Disease Associations	1.0	1.1529
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15248
SKMEL3	CCLE Cell Line Gene CNV Profiles	1.0	2.82486
Vesicle-mediated transport	Reactome Pathways 2024	1.0	null
BRD-K53281329_SYK-inhibitor_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K13754152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14768
establishment of protein localization	GO Biological Process Annotations 2015	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.38046
QD-57-GT11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256591
BRD-A68930007_OUABAIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020418
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49133
PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163021
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_57_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.81214
u2197	HPA Cell Line Gene Expression Profiles	-1.0	-1.45928
BRD-A80213327_NSC 23766_COV644_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1078
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.40865
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04828
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1728
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09073
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9504
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1217
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8259
Weight Loss	CTD Gene-Disease Associations	1.0	1.4275
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7758
medial (main) part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41421
Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02881560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17841
BRD-K76703230_YM-155_AGS_6.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00961331
MDA-MB-330	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.396
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.9667
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280822
PSN1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.27752
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2124
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828634
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.848571
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15683
CORL105_LUNG	CCLE Cell Line Proteomics	1.0	6.12834
TACR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00636972
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Palmatine (chloride)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0268694
Mesothelioma_MESO_TCGA-MQ-A6BN-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60623809_SU11652_SW480_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
diethylstilbestrol_rattus norvegicus_gpl1355_aci_gds2913	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47445
BRD-K39664334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05116
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.02
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.857261
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69389910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27464
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10189_KD_JMJD1C_SRP050058	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.8565
AT7519_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0081207
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2668
KAT2A	ENCODE Transcription Factor Targets	1.0	null
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10977
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32198
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.344446
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19C-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05841284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45471
A549_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171312
golgi apparatus	LOCATE Curated Protein Localization Annotations	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231471
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03795
AC-91-WE67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201146
GTEX-QDVJ-1226-SM-48U1V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16256
FCRL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051329
AA-48-XT80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227167
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18252
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
troxerutin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02296
MCF7_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132909
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861039
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-O5YT-0126-SM-48TBW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80912
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SE-0726-SM-2XCD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860122
Dehydration_Hypothalamus_GSE3125	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.73069
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06535
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29317
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05541
KMT2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049018
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XMK1-1326-SM-4B65Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02848
OSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09326
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QV44-1926-SM-2S1RF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915609
NANOG-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BNIPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06411
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212852
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A4IJ-01A-31R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1461
CRCGN016_MCF10A.WT.HP_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44237
BRD4-27068464-CHIP-SEQ-AML-CELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
UA-39-TN76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291745
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87632
trastuzumab_homo sapiens_gpl6947_gse31432	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86382
A549_Tucidinostat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013166
H3K9me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
G118	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.89853
BRD-K72238567_656402-250MG_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PC-18-VX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314518
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.693087
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.94185
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45529
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894437
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.40768
A549_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141105
hsa-miR-4468	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-A04553218_chlorpheniramine_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MD-86-UW46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353198
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RORC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558013
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2686
integument	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385217
MFAP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00731494
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67752
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2605
BRD-K16485616_S1122_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JHUEM7	DepMap CRISPR Gene Dependency	1.0	5.29066
GTEx AdiposeTissue 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	5.25336
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28802
cdkn1b_18180298_3t3_lof_mouse_gpl1261_gse9161	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.021838
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.60372
Blood-non-classical monocyte	Tabula Sapiens Gene-Cell Associations	1.0	-0.167556
GSE88819_5_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-6837-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134191
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.73073
Spinal nucleus of the trigeminal, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54871
WC-59-RG09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224511
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tachyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.066
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268379
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
YD-21-ZR41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214029
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4037
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44117
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05378
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297913
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.502789
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16148
16651409-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01975
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lower basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12495
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183271_4_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HS742T	CCLE Cell Line Gene Expression Profiles	1.0	1.47391
BRD-K09499853_KU 0060648 trihydrochloride_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE223008_6_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Golgi apparatus	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866026
GTEX-XYKS-1226-SM-4BRVI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974934
viral capsid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.48005
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WY7C-2326-SM-3NB2U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21553
GATA1	ENCODE Transcription Factor Targets	1.0	null
DB-34-QA60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280747
GTEX-X5EB-1726-SM-4E3J7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28775
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.053115
IZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34264
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90017
coated vesicle	GO Cellular Component Annotations 2025	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.886856
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10991
BRD-K67141726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07196
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.26673
ED-02-CL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458685
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82919339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23559
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33183
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_HA1E_24.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K02562327_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35601
MMRN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633595
GSE224970,GSE224971_1_v_0_sap30_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50045741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66117
BRD-A59995060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21549
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79878
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_12322_KD_BMAL1_SRP186908	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.1675
FOS	ENCODE Transcription Factor Targets	1.0	null
SmoothMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.906976
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Monocyte_Spleen_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
organelle organization	GO Biological Process Annotations 2023	1.0	null
BRD-K36134372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15487
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.923828
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33058
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220745
GSE220613_0_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.91429
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.47578
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50221
MSTO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00852374
COPI-mediated anterograde transport	Reactome Pathways 2024	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
A549_FLLL32_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222299
A549_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195544
BRD-K51575138_TPCA-1_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06029218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78347
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149041
BRD-K97472167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12966
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K12111274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19851
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.31487
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9965
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of PSPa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01875
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876648
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50483
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraventricular hypothalamic nucleus, parvicellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99946
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17228
BRD-A75409952_wortmannin_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.3101
nucleus sagulum, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35256
Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUPR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477377
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.867843
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3966
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24142
Prostate adenocarcinoma_PRAD_TCGA-G9-6343-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8Q9-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03719
DD-55-AU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206876
posteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20735
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27391
Laterodorsal thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.887
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.847417
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54828
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.879067
POM121L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587548
19218430-TableS3	GeneSigDB Published Gene Signatures	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.796303
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HGC27_STOMACH	CCLE Cell Line Proteomics	1.0	11.2491
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04443
Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.3106
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.533271
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11345
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKMEL5	CCLE Cell Line Gene Expression Profiles	1.0	1.8679
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48392
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Golgi vesicle transport	GO Biological Process Annotations 2023	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pendred Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19268
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4305
ZNF750_KD_GDS4599_177_human_HaCaT keratinocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4863
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.864708
oncogene	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4510-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.765359
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NALM-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.950502
FOXA2	ENCODE Transcription Factor Targets	1.0	null
BRD-K12502280_TG101348_HT29_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE100316_5_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JB-89-SI60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279
Perturb_17145_OE_Xbp1_ERP110244	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.8099
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.30205
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01546
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6768
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515518
10287_ZNF324_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582913
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.28919
fat_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.955371
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
MCF7_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134668
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78M-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131876
Mahlavu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.233
SW 527	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.67756
Perturb_5728_KO_Cdh1_SRP149531	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.76746
GTEX-P4QT-0126-SM-2I3FL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14352
PMC9464213-41467_2022_33063_MOESM9_ESM.xlsx-BNC2_peptides-gene_name_BNC2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5757
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854901
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_VCAP_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RHD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065535
BE-38-UW72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326706
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42593
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCARA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601015
BD-69-GX17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436647
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021116
BRD-K17412949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39272
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.66228
Tolmetin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0196133
BRD-K81418486_vorinostat_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CHEMBL2397099	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MPZL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00414268
Pulvinar	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00806
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9201
MYC-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
RMUGS	CCLE Cell Line Gene CNV Profiles	1.0	2.00463
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.38521
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-WFG7-1326-SM-4LMK1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867383
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257367
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_107_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10352
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-86-OB87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.12007
Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0603
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934572
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174449
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.93262
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453415
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_9614_KO_Rprd1b_SRP241887	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.80078
BRD-K61978712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04732
A549_Navitoclax_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115127
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.154
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.849359
BRD-K76738405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1073
Endoplasmic reticulum exit site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.078
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
16166618-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NRF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K25842662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41952
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-1426-SM-4BOPR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84659
UF-14-LK87_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.521989
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.73129
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE176008_7_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Rapamycin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0230426
GTEX-OIZG-0726-SM-33HBL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13727
GTEX-WY7C-2126-SM-3NB2R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828835
SMAD4-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K47658117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54274
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Golgi stack	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13716
PMC7887593-ADVS-8-2003526-s002.xlsx-LCM_AR_vs_BR-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165101
Interleukin 18 Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
1067_RTL10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512241
BRD-K01263144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16356
PMC12824706-BLOOD_BLD-2025-028441-mmc3.xlsx-Fig4B_genes_inc_expr_NRF1-gene_name_NRF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KKU100	DepMap CRISPR Gene Dependency	1.0	7.55048
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2344
RPMI-8226 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
GTEX-SNMC-0926-SM-4DM5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45167
EZH2	ENCODE Transcription Factor Targets	1.0	null
GSE113734_1_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-1626-SM-48TCQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836396
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893311
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.61936
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.88585
ESC_J1_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
K562_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194665
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
19168792-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00348
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12098
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.26629
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
DHTKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44164
Lung squamous cell carcinoma_LUSC_TCGA-66-2758-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.797
GABPA	ENCODE Transcription Factor Targets	1.0	null
BRD-K67844266_MLN4924_COV644_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89402
BRD-K32018176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0358
EA-39-WW34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204319
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWS6-0826-SM-47JXF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97432
prostate	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90749965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79037
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27391
NCIH660	Achilles Cell Line Gene Essentiality Profiles	1.0	1.09787
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33253
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.967271
WB-82-EL69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207543
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50093
BRD-A01759464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10794
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20109
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.354
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287867
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LN235	CCLE Cell Line Gene Expression Profiles	1.0	1.38292
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24509
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124578
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC56	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76984
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863601
MCF7_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165731
A549_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152702
BRD-K68562280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4954
large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.205916
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00964
K562_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161397
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.22868
PANC1005	DepMap CRISPR Gene Dependency	1.0	2.31154
GUCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47256
AF-12-IW93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32576
vesicle coat	GO Cellular Component Annotations 2023	1.0	null
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Oxaprozin_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231032
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29123
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.01
ER to Golgi Anterograde Transport	Reactome Pathways 2024	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE181966_5_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Golgi-associated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.625
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3994
EE-32-EY37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.387571
PMC6097700-pgen.1007515.s007.xlsx-S1_Table-S1_Table_SATB2_NuRD_gene-set_list_SATB2	Rummagene Transcription Factor Associations 2026	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367598
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131294
MALME3M	CCLE Cell Line Gene Expression Profiles	1.0	1.40628
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.6213
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5043
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.967314
plexiform layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42183
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689339
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A25869984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88916
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837199
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10988
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.3605
Membrane Trafficking	Reactome Pathways 2024	1.0	null
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.92515
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-D-HEP3_UP_AA_UP_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33763
GSE203017_0_v_1_irs2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930522
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03724
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133395
GTEX-TMZS-0126-SM-3DB9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900729
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.6503
CEBPB-24764292-MC3T3-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FE-06-GR60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368519
BRD-K94493764_NP-009169_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35111
E2F1-26619117-HEPATOCYTES-MOUSE-LIVER	ChEA Transcription Factor Targets 2022	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20381
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80736363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01341
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350104
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44076
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ID4_KO_GDS4178_620_mouse_Splenic B cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-A08363225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93317
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TFAP2A-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2223
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
COPII-coated ER to Golgi transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.652
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
SNU-638 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16037
hsa-miR-4792	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K43069600_12K-516S_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
8271_SON_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.96429
SHQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62367
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.11583
colonrectum_a	HPA Tissue Sample Gene Expression Profiles	1.0	0.986386
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.249
BRD-K93567937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41541
BRD-K92655427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36356
Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07384081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07518
estradiol_homo sapiens_gpl96_gds2324	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.489858
CUX1	ENCODE Transcription Factor Targets	1.0	null
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36382
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU3F2	ChEA Transcription Factor Targets	1.0	null
GTEX-WHSB-1326-SM-3LK6W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913865
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-D-HEp3_UP_NR2F1_Ind_UP_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10479
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185572
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8222_SNRNP70_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.714698
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14433
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.52381
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.660026
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100328_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.02945
Uterine adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RA-42-CM42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.472582
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20423
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04067
5430_NAA38_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10364
A549_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105367
BRD-K09854848_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.41758
BRD-K46897949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21512
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
SRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550376
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53908
GSE162276_2_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Momelotinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.88
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
r9 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27854
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274206
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU8-0126-SM-2XCDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06344
urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01599
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1832
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JUND_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82466
EOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01209
GSE160293_2_v_4_celf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9198
GSE198794_0_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.573268
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2244
GSE232631_5_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-49-BD04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253707
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.16199
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A95820578_NP-006304_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-5784-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
8190_SMU1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.51865
golgi membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-X4XY-0826-SM-4E3JM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88571
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02864
BA-46-YF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.655913
BRD-K72588970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33023
BRD-K80965028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32218
MCF7_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105224
ventral pallidum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05219
CTCF_WI38_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12003101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26385
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.71945
AD-09-MD49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390895
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.877181
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05378
LCLC103H	DepMap CRISPR Gene Dependency	1.0	2.10449
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.397941
SS18L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45177
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2911
BRD-K12502280_TG101348_RKO_6.0_h_11.1000003815_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COPI vesicle coat	GO Cellular Component Annotations 2023	1.0	null
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240219
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12315
CF-42-OS28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.441278
H3K36me3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0626-SM-48TZU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893892
BRD-K90027990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47085
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37455
GSE181461_1_v_4_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.54061
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.836709
REC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60763
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
PMC3515505-1476-4598-11-71-S1.pdf-7-FBXL10_KDM2B	Rummagene Transcription Factor Associations 2026	1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76808
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215461_0_v_1_topotecan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UMUC9	DepMap CRISPR Gene Dependency	1.0	5.6946
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6789-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972725
BA-86-AL61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410396
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.852099
BRD-K18930370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62386
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR	Rummagene Transcription Factor Associations 2026	1.0	null
REV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55004
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.890952
GSE174383_6_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SD-69-QA40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279738
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845455
CE-95-YX02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24137
FC-62-AI14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204645
PPARG-23326641-C3H10T1-2-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.4403
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.22181
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18397
TAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16718
MCF7	CCLE Cell Line Gene Expression Profiles	1.0	1.82839
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-1626-SM-3P618	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13673
BRD-K73402542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28429
HE-14-AT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208897
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054634
Lung squamous cell carcinoma_LUSC_TCGA-56-7822-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21859
GTEX-WYJK-0126-SM-3NMAB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02138
MCF7_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191135
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-2.06114
GTEX-X5EB-1826-SM-4E3K8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29663
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_9_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21661
15471956-Table2	GeneSigDB Published Gene Signatures	1.0	null
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.206248
GSE239578_2_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11305
OTX2_silencing_GDS4472_136_human_D425 medulloblastoma (MB) cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3436-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2044_KO_Srf_SRP038094	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.18876
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.473
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M3-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-10-VU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286486
K562_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019976
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921813
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.04355
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.885206
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.85917
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.78681
PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Middle temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.669
AB-82-ES53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414377
A549_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174267
K562_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167771
CPHXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16223
SPOP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61849
hsa-miR-30a-5p	MiRTarBase microRNA Targets	1.0	null
BRD-K32164935_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JB-23-ZE86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360393
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
VCAP	CCLE Cell Line Gene CNV Profiles	1.0	1.63598
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.28535
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207521
BRD-K51017127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98158
BRD-K28795679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20228
FOXP2	ENCODE Transcription Factor Targets	1.0	null
Midbrain trigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04013
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16375
MCF7_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152853
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6111
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82688
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040854
DOTC2-4510	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15259
PEX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15457
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.739742
TP53-20018659-R1E-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53844
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.70493
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.79981
BRD-K96076993_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
adipose tissue	HPA Tissue Gene Expression Profiles	-1.0	-0.832042
A549_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192449
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19401
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4067
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30202
BRD-K09607752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55923
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.214
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3163
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267089
NB-58-SA13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23051
cis-Golgi network membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.218
ZR7530	Achilles Cell Line Gene Essentiality Profiles	1.0	1.47992
BRD-A47513740_calyculin A_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
3823_HMG20B_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500204
Rimonabant_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.019534
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0638
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-42-YI34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.661913
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-06-OB47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262098
BRD-K51575138_TPCA-1_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436091
GSE193541_0_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211838
GA-77-MH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320967
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10047
BRD-K71437774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03822
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89261
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73524
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Barrington's nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11621
BRD-K75626008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0579
PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134433
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.937654
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206562
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.77531
BRD-K56653679_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.10508
GSE180200,GSE180201_5_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-09-MD49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364055
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18190982_COT-10b_HEPG2_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K48299239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57597
GSE252958_1_v_0_znf469_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60743396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00474
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05355
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-1926-SM-3LK5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979995
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206003
GSE164463_3_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.398
GSE188814,GSE188854_0_v_1_wtap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265121
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.957933
BRD-K16798053_ST4029573_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Precatalytic spliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.51
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863019
K562_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023305
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SKNMC_BONE	CCLE Cell Line Proteomics	1.0	5.27484
Cingulate gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.116
A549_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218504
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.89893
TTC39A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540554
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Goblet cell_Small intestine_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE168676_0_v_3_dach1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168826
RFX5	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57769
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131553
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.824558
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55067
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169744
cell part	GO Cellular Component Annotations 2015	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.75984
IRAK-1-4 Inhibitor I	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
9656_USP39_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22128
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15353
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03618428_PP-110_SKM1_6.0_h_22.2_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.93076
BC-00-YH62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.587721
BRD-K75840180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15455
BRD-K77935284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56266
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23906
KDM1A	ENCODE Transcription Factor Targets	1.0	null
Perturb_13511_OE_Nfkbiz_SRP234708	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.95306
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5388
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00605
UBE2E2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487108
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.94436
K562_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147315
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.7892
BB-55-JH29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307474
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Roxadustat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126225
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83005
MZ2-MEL	GDSC Cell Line Gene Expression Profiles	1.0	1.6895
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.23786
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.39049
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.72129
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.974168
GTEX-XXEK-1626-SM-4BRUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09571
GTEX-T2IS-0126-SM-4DM6O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96181
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33449
SJSA1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.07097
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37086
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1596
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_15133_OE_Klf10_SRP360603	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023397
GSE255680_1_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.914157
Medial geniculate complex, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5017
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27391
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4096
AD-58-PW17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309861
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.94555
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989926
MCF7_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0224214
skin	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K63008302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55033
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPJH-0226-SM-3GADV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861199
Lung squamous cell carcinoma_LUSC_TCGA-66-2785-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155102
Brain Lower Grade Glioma_LGG_TCGA-DU-5870-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365828
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.42238
DA-10-GX45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264339
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSF1R_druginhibition_195_GSE57686	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.15089
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.664584
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.978944
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77609086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33169
FOLH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682479
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26432
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.576
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
A549_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115838
MCF7_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163534
Lung adenocarcinoma_LUAD_TCGA-86-8585-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tmed3	GeneRIF Biological Term Annotations	1.0	null
GTEX-NFK9-1126-SM-3LK78	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08919
Triamcinolone_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.022365
GB-46-CK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222061
MYC	ChEA Transcription Factor Targets	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02229
DENND5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5578
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184442
protein transport	GO Biological Process Annotations 2025	1.0	null
BRD-K04853698_-666_NCIH508_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03689
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06761
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDST8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99802
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328488
TCF12	ENCODE Transcription Factor Targets	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.879465
BRD-K50851442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0789
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior commissure	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.748
PMC5848610-supp_gr.228809.117_Supplemental_Table_S3.xlsx-Table_S3F-Supplemental_Table_S3F_ZFX_binding_pattern_clustering_information_for_genes_with_promoters_bound_by_ZFX_related_to_Figure_2I_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.98533
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
TMEM98	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00700973
BRD-A36318220_Necrostatin-1_RKO_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13342
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-FX-A3TO-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045183
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.82874
MCF7_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126221
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF10A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.773597
Type 1 diabetes mellitus_Myocardial tissue_GSE4616	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.25213
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195894
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0726-SM-48TCS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908652
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56097
SNRK_overexpression_127_GSE30185	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.54282
MCF7_Epothilone A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146741
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84935293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16619
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE208254_4_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47131
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936332
GATA3-24758297-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180792
YA-85-VH07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251804
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244767
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Postsubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42243
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3101
E2F1-21310950-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41S-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94439911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78137
BRD-A19633847_PERHEXILINE MALEATE_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T2IS-0826-SM-4DM6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60949
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31223
Golgi-associated vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K67092184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72572
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913594
SMAD4-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
AA-32-DP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.693176
PAX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556757
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.952159
BRD-K24977393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91741
BRD-K24133999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0717
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013301
Busulfan_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0310774
Lung adenocarcinoma_LUAD_TCGA-95-7948-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0426-SM-32PLO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20653
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52258
Adrenocortical carcinoma_ACC_TCGA-OR-A5JG-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3VY-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3043_KD_Ppp1r13l_ERP023515	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.7981
BRD-U66370498_BL-081_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22665
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraventricular hypothalamic nucleus, magnocellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.29933
Uterine adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958119
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0126-SM-3NMD6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89614
GTEX-T8EM-0526-SM-4DM64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04102
HIPK2_knockdown_106_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.83077
DC-02-OP01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220587
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.67349
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MEX3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552509
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.72481
BRD-K17953061_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14575
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Golgi membrane	GO Cellular Component Annotations 2025	1.0	null
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10512
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985698
GTEX-XLM4-0726-SM-4AT64	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86486
CST6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044794
Paragigantocellular reticular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1354
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.645395
MCF7_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146628
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01262
P3HR1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64398
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.66094
PMC11309649-medi-103-e37185-s002.xlsx-Sheet1-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.982988
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.67771
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93998074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01076
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83574
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.926925
BRD-K55105453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90792
PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
SF3A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576154
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Clear cell renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
BRD-K50234570_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017559
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K62289640_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.71491
r8 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00135
CREB1	ENCODE Transcription Factor Targets	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151946
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52409
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HA-32-YH61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273824
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-8.6373
MAPK8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056424
superficial stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22935
BRD-K57251296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64363
BRD-A44780397_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Idoxuridine_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0150923
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43055
EID2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16279
XRCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13608
Ventral posterolateral nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16053
GATA1_G1E-ER4_mm9_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875616
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05759
A549_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144331
GATA1_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.804644
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85997
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82570855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42342
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XX-0126-SM-3NMC2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39258
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r2 liminal central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28293
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3009-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metastatic	GeneRIF Biological Term Annotations	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3921
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265458
GSE198165,GSE198166_5_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2722023__F4	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-A67788537_Salermide_NOMO1_6.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80690345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2855
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CSNK1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521032
7164_RBM22_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38647
BRD-K19136521_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE128333_4_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178378
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8628
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
ID-90-NM43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.565041
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8299
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6149
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01109
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
LEUTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63518
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952761
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49416
PANK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30336
BRD-A33119430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3209
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68548958_-666_NOMO1_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38105
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78431006_HY-50878_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A35588707_TENIPOSIDE_U937_6.0_h_1.25_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06573
BRD-K09499853_KU 0060648 trihydrochloride_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.975457
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39905
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ishikawa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
K562_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189273
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27147
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null