association dataset threshold value standardized value SNX21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.8629 YY1 ENCODE Transcription Factor Targets 1.0 null MDAMB436 CCLE Cell Line Gene CNV Profiles -1.0 -1.4912 INSIG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95879 H3K9me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MRGBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17353 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLFN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98406 GPT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46736 SEPTIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51326 H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFKB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63827 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null HS 578T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09964 LYL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29617 HOXC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97333 H3K27me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.971935 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6259 Liver GTEx Tissue Gene Expression Profiles 2023 1.0 1.85643 ORC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92685 GALNT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97123 olfactory tubercle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.878118 FOXO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09267 VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.830147 RALDH2_KO_GSE43578_6_mouse_head (rostral or posterior) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.961943 H4C14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28202 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null C1orf56 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67029 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.508 V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20774 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3423 HOP62 DepMap CRISPR Gene Dependency 1.0 2.11286 RDH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35328 NFKB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.2078 HN CCLE Cell Line Gene CNV Profiles -1.0 -1.52517 ATRFLOX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00516 BE2M17 DepMap CRISPR Gene Dependency 1.0 2.59174 ZNF605 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18337 ZNF488 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80461 OSGEPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07692 organelle LOCATE Predicted Protein Localization Annotations 1.0 null ALG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58974 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.52043 NR1H4::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0435 ZIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0904 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ALKBH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09161 FEV JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5648 UBE2Z CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8093 ATP1A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26808 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LACTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29081 PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null GSE185519_4_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null RMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.586 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DLG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88401 substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01251 Osteonecrosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.497 VIIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13002 TENT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32226 SNAPC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80207 ZNF287 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7194 PPP2R5E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01238 transient Purkinje cell clusters Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25238 TRAPPC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93313 C8orf48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38236 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.96789 hsa-miR-4459 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 HNF1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36517 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58353 ICAM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83792 IL17RB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62731 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.81049 ALX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97056 Spleen GTEx Tissue Gene Expression Profiles 2023 1.0 2.81317 related GeneRIF Biological Term Annotations 1.0 null Gluteal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.557 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.996576 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE150134_1_v_0_fluorouracil_human RummaGEO Drug Perturbation Signatures -1.0 null EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PATU8988S CCLE Cell Line Gene CNV Profiles -1.0 -1.58099 GSE233679_12_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null family GeneRIF Biological Term Annotations 1.0 null ZC3H18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69648 CD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.946 disease GWASdb SNP-Disease Associations 1.0 0.025186 KU812 CCLE Cell Line Gene Expression Profiles 1.0 1.43348 ZRANB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28949 globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.88985 NEK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93589 BACE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45814 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EVX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16297 MDAMB361 DepMap CRISPR Gene Dependency 1.0 3.37672 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF565 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59642 nucleus of diagonal band Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01204 hsa-miR-4281 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 molecular_function GO Molecular Function Annotations 2015 1.0 null HSPB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76502 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COL5A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76874 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null KALS1 CCLE Cell Line Gene CNV Profiles -1.0 -1.44442 ACTN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90997 PPP1R14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61701 H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS454 CCLE Cell Line Gene Expression Profiles -1.0 -1.69605 H3K27me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Gli1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.9648 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.72092 POLR2AphosphoS5_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COASY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11307 BMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61466 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null calcium GeneRIF Biological Term Annotations 1.0 null MED19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16875 TINAGL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92033 medial habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.837531 HES3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64922 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF2B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74606 ZNF524 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.02 REEP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96021 area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.33168 Psoriasis vulgaris_Skin tissue_GSE14905 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.9609 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AKAP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11739 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PYGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71315 TOP1MT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7055 GSE224096_2_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null Minor Salivary Gland GTEx Tissue Gene Expression Profiles 2023 1.0 2.43017 SCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95526 hsa-miR-296-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FANCG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58305 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null PEX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75753 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26508 RIMKLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73607 CLPX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39461 H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF354C JASPAR Predicted Transcription Factor Targets 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.16424 ZNF76 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79037 POU3F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50465 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.39714 SKNAS CCLE Cell Line Gene CNV Profiles 1.0 1.77434 THRAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00074 lytic vacuole LOCATE Predicted Protein Localization Annotations 1.0 null JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.996576 TE15 CCLE Cell Line Gene CNV Profiles 1.0 1.35827 MYCN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8305 NUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7888 DHX34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93459 WDR91 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.56371 ERCC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02729 BRD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55349 FOXB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21957 JAK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05473 ADAM15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40635 ANTKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47012 A2058 DepMap CRISPR Gene Dependency 1.0 2.30318 premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.8842 LRP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97296 FASTKD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64273 H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GON4L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76766 BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9411 BTBD18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85532 IMR32 CCLE Cell Line Gene CNV Profiles 1.0 1.65718 MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.2276 RPS4Y1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40822 MCAS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896466 MAPKAPK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6722 gamma GeneRIF Biological Term Annotations 1.0 null FAM131A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47949 SULT4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11833 MEWO CCLE Cell Line Gene CNV Profiles 1.0 1.5534 MITD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84647 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TM31 CCLE Cell Line Gene CNV Profiles -1.0 -1.34003 H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PFDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29278 IRX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34185 SBNO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37814 DNAJC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24412 ARNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11138 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26503 MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16315 ZNF680 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6136 GSE128333_3_v_5_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null PGBD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.36879 IAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41639 NSMCE4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28146 ACSBG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79752 fallopian tube GTEx Tissue Gene Expression Profiles -1.0 -2.07996 DTX3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84199 GDF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6957 ANKEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35823 CA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84846 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22348 496100608_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.09887 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.028376 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3194 PLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1474 Brain_CT2_COP 41 HuBMAP ASCT+B Augmented with RNA-seq Coexpression 1.0 null COMMD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52471 MAX ENCODE Transcription Factor Targets 1.0 null ZNF99 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70835 VAChT_KD_GDS4325_361_mouse_Heart from C57BL/6 males GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MVD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40365 cingulate gyrus, retrosplenial part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.843276 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null WDR54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3319 SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null voltage GeneRIF Biological Term Annotations 1.0 null RARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7391 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.832889 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28963 AASS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4093 NCIH322 DepMap CRISPR Gene Dependency 1.0 2.2585 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null tmem235 GeneRIF Biological Term Annotations 1.0 null CSNK2A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78314 KRTCAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36368 inner CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.829596 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56899 UMPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76695 ARHGEF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48697 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HUP-T4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07992 pituitary GTEx Tissue Gene Expression Profiles 1.0 1.20379 CEBPB ENCODE Transcription Factor Targets 1.0 null H2BK5ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05105 NDUFA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5554 KLRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04204 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.8398 CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SFMBT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48584 CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.941551 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.996576 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null PRMT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62194 CAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12856 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28682 CAVIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15127 ZDHHC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62019 ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.1011 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-663b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 PMC11947124-41419_2025_7562_MOESM1_ESM.docx-156-ENSG00000025156_HSF2 Rummagene Transcription Factor Associations 2026 1.0 null MOR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09964 RBBP5 ENCODE Transcription Factor Targets 1.0 null ESRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83424 H3K27me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12179407-MCO2-6-e70261-s004.xlsx-up_TET3-KO_PQ_vs_Cas9_PQ-Unnamed_10_TET3 Rummagene Transcription Factor Associations 2026 1.0 null NECAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11286 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16226 WDR90 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49517 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45643 HDAC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86667 PINX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46738 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RBPMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8037 DANG CCLE Cell Line Gene CNV Profiles -1.0 -1.45135 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null channel GeneRIF Biological Term Annotations 1.0 null GBX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22331 YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reticular nucleus of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.52057 POU4F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38693 Mayer-Rokitansky-Kuster-Hauser syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.739 GALNT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01449 MC116 CCLE Cell Line Gene Expression Profiles 1.0 2.72277 TYMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68373 DDX51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06556 USO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13832 HOXC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47685 LOX-1_OE_GDS4262_433_human_HAECT - aortic endothelial cell line - 6 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 143B CCLE Cell Line Gene CNV Profiles -1.0 -2.55888 WDR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93115 GSE233679_6_v_4_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null TP63 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75945 UCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10632 SKNSH DepMap CRISPR Gene Dependency 1.0 3.67442 LRRC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67598 OCIMY5 CCLE Cell Line Gene CNV Profiles -1.0 -2.01561 PAN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29069 IGFBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39662 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05105 SNU46 DepMap CRISPR Gene Dependency 1.0 3.77106 KDELR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21423 DDX59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35442 layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10151 PMC10824666-43018_2023_699_MOESM2_ESM.xls-Suppl_Table_S4-AM-1882_AUC_vs_Gene_Expression_PRISM_Breast_and_Ovarian_Cancer_Cell_lines_n_58_PRDM6 Rummagene Transcription Factor Associations 2026 1.0 null GSE182180_1_v_2_secretin_human RummaGEO Drug Perturbation Signatures -1.0 null CLSTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41164 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.92866 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KANK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37854 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVKATE CCLE Cell Line Gene CNV Profiles 1.0 1.64676 NME4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75133 H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null apical plasma membrane GO Cellular Component Annotations 2015 1.0 null NB6 DepMap CRISPR Gene Dependency 1.0 2.28213 HACL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30561 RPL36AL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18353 intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX::MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9524 ZNF608 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99953 ERG28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66298 HCC1171 CCLE Cell Line Gene Expression Profiles -1.0 -1.78895 GCHFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35845 H3K4me1_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MOLP8 CCLE Cell Line Gene Expression Profiles 1.0 1.39855 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.24642 SLC12A7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82785 SK-N-FI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835177 ZBTB7A ENCODE Transcription Factor Targets 1.0 null KNS60 DepMap CRISPR Gene Dependency 1.0 2.13958 TMUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98075 IFT52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32121 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40732 HDAC6 ENCODE Transcription Factor Targets 1.0 null Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.7457 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null RPL35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51663 SEZ6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19089 FBXL19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83599 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25868 TACC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42344 NCI-H250 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30543 COPS7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49322 MZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01015 ARL6IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36209 TSPAN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06693 cellular_component GO Cellular Component Annotations 2015 1.0 null GSE142684_3_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null C14orf28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37053 Olig2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.8537 C10orf88 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23445 TYSND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63663 SW982 DepMap CRISPR Gene Dependency 1.0 5.72596 CS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66443 MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C2BBE1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.960505 HSD17B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68897 Male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.83828 GSE185519_1_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.72092 CHRAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3421 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null ACOT13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70082 ZNF80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60566 RDH11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67712 FLOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3857 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.87095 NIPSNAP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85007 RELA ENCODE Transcription Factor Targets 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null CNEP1R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6736 VCY1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40782 YAPC CCLE Cell Line Gene Expression Profiles -1.0 -1.50966 hsa-miR-3943 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 hsa-miR-4676-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 PEX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33031 RNPEP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79315 H3K27me3_iPS-15b Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FAM118A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11852 SNU-638 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835177 GSE245778_1_v_0_runx1_human RummaGEO Gene Perturbation Signatures -1.0 null UBE2J1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12377 skeletal muscle HPA Tissue Protein Expression Profiles 1.0 1.19416 GSTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87093 H3K27me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ORMDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43218 red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.95037 H4K20me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4263 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.86563 UACC893 CCLE Cell Line Gene CNV Profiles -1.0 -1.3364 EW8 CCLE Cell Line Gene Expression Profiles 1.0 1.66055 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2I CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04458 ACBD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00683 H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANKRD13B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67755 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.944828 HEP3B217 CCLE Cell Line Gene Expression Profiles -1.0 -1.59921 ALDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85758 MCM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34846 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.927022 ZBTB33 ENCODE Transcription Factor Targets 1.0 null LRRC40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41701 GSE195559_8_v_4_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null GNB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71648 EB2 COSMIC Cell Line Gene Mutation Profiles 1.0 null RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU1066 DepMap CRISPR Gene Dependency 1.0 2.13502 H3K27me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH524 CCLE Cell Line Gene CNV Profiles 1.0 1.55914 CL-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03078 HSPA12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69252 FGFR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03947 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.992435 PMC10247733-41408_2023_863_MOESM4_ESM.pdf-574-ZSCAN1_ZSCAN1 Rummagene Transcription Factor Associations 2026 1.0 null FRMD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37724 HSF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8829 CLIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59221 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OTUD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10403 H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LN229 CCLE Cell Line Gene CNV Profiles 1.0 1.51077 SLC66A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92467 H3K27me3_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCAR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31643 VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14679 ZSCAN9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75402 Urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.30048 PLEKHB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61111 GPR161 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77095 496100531_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05646 SLC27A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8402 intracellular part GO Cellular Component Annotations 2015 1.0 null KIF4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95673 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.76507 BAZ2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16259 NCIH441 CCLE Cell Line Gene Expression Profiles 1.0 1.96635 BZW1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67921 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null ATP5IF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91593 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180185_9_v_8_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null PAX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17526 DCANP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16727 Brain - Spinal cord (cervical c-1) GTEx Tissue Gene Expression Profiles 2023 1.0 1.57754 RARA::RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.7042 TCF23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6617 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLHL26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50175 H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Amp_AA-TCGA-Unnamed_20_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null CLCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20837 SYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9831 ABHD17C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37783 SHMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.235 plasma membrane region GO Cellular Component Annotations 2015 1.0 null UBE2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39395 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Apical plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 SEKI DepMap CRISPR Gene Dependency 1.0 2.20964 PASK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22601 PMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9132 TBX20 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.5758 FKBP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75636 TMEM267 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29147 ZNF334 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7893 KE39 CCLE Cell Line Gene CNV Profiles -1.0 -1.48656 SORBS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87988 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.957118 BV173 CCLE Cell Line Gene Expression Profiles 1.0 2.03354 WDCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45193 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-2355-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 membrane region GO Cellular Component Annotations 2015 1.0 null H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1568 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.960257 SLR20 DepMap CRISPR Gene Dependency 1.0 2.27719 MEL-JUSO COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 FOXD4L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47183 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.996576 HDLM2 CCLE Cell Line Gene CNV Profiles -1.0 -2.09259 GJC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3878 globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47598 LN-229 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.26762 CDK17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.825 UQCRQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78244 TOR1AIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93333 voltage-gated calcium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.449 DERL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0726 TXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79591 TXNDC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01372 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38827 GSE139239_2_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HSF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0574 NB17 DepMap CRISPR Gene Dependency 1.0 6.83667 CEP55 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82587 hsa-miR-4790-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 SLC52A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15578 SEC14L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.69977 H3K27me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null testis HPA Tissue Protein Expression Profiles 1.0 0.71557 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.1888 SKMG1 DepMap CRISPR Gene Dependency 1.0 2.16426 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3194 SURF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42513 ANHX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25832 MELJUSO CCLE Cell Line Gene CNV Profiles 1.0 2.28807 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.946511 GB1 CCLE Cell Line Gene Expression Profiles -1.0 -2.35885 NPEPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50886 AKAP8L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15527 NR0B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40142 PPP1R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1194 TARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06046 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.83015 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.61534 PAX5 ENCODE Transcription Factor Targets 1.0 null RASGEF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98537 SLC25A45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92729 ZNF143 ENCODE Transcription Factor Targets 1.0 null GSE128333_4_v_1_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Female reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 YIPF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95901 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04646 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38419 D502MG DepMap CRISPR Gene Dependency 1.0 3.80334 NCKIPSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64626 BST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88088 RNFT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1135 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.163124 HDAC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54699 H3K9me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SLC48A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21165 MRE11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95178 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30543 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139239_1_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF157 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98424 CNDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02148 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null COV504 CCLE Cell Line Gene CNV Profiles 1.0 2.74036 GSE110708_1_v_3_adar_mouse RummaGEO Gene Perturbation Signatures -1.0 null RNF227 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92939 PLEKHN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.36139 ZEB1 ENCODE Transcription Factor Targets 1.0 null central medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01055 lysosome LOCATE Predicted Protein Localization Annotations 1.0 null SNRPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23911 NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.6503 STARD3NL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96181 DDX39A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.5781 RPS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99226 hsa-miR-1227 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112202_5_v_2_digoxin_human RummaGEO Drug Perturbation Signatures -1.0 null TC32 CCLE Cell Line Gene Expression Profiles 1.0 1.46463 SLC43A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77258 CHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80528 MM253 DepMap CRISPR Gene Dependency 1.0 2.9098 ZNF544 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98491 H9 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.26268 HSBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85116 JHOM2B CCLE Cell Line Gene CNV Profiles -1.0 -2.15882 SUZ12 ENCODE Transcription Factor Targets 1.0 null MSN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17213 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null BAMBI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37152 C3A CCLE Cell Line Gene Expression Profiles 1.0 1.35417 membrane part GO Cellular Component Annotations 2015 1.0 null NSUN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90969 ENTPD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9688 USF MotifMap Predicted Transcription Factor Targets 1.0 null NAAA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45583 CD83 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56277 FSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89137 PES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30078 CAKI1 CCLE Cell Line Gene CNV Profiles 1.0 1.35038 ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896466 cerebellar vermis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13205 ZNF667 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77547 SLC7A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02931 SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10992 STON2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89636 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal raphe nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06105 CALB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42463 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null UMUC3 CCLE Cell Line Gene Expression Profiles 1.0 1.56173 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCFSTTG1 DepMap CRISPR Gene Dependency 1.0 2.55319 POU6F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64516 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.84332 DMRTA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5579 BAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16783 NUP188 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68355 NOP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.64034 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.31094 HCT 116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00362 NUGC4 CCLE Cell Line Gene CNV Profiles 1.0 1.74123 PMC6360815-supp_gr.239053.118_Supplemental_Table_S2.xlsx-MAFs_targets-Table_of_potential_MAF_targets_MAF Rummagene Transcription Factor Associations 2026 1.0 null III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.18671 FYTTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66816 MRS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69033 ARL14EP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81153 KP2 DepMap CRISPR Gene Dependency 1.0 2.80019 GET3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76524 PCNX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41109 EIF1AY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31995 EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE109530,GSE109531_1_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null SLC25A32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72709 GINS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83189 GMIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88218 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BARX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06207 TCCSUP CCLE Cell Line Gene Expression Profiles -1.0 -1.72842 GSE185519_4_v_7_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null ABRAXAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12141 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15396 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.90578 RESF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38224 NIHOVCAR3 CCLE Cell Line Gene CNV Profiles 1.0 1.78079 SLFN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22435 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.915074 MKN1 CCLE Cell Line Gene CNV Profiles -1.0 -1.48789 substantia nigra, pars reticulata, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18904 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALU-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25734 H3K27me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25868 A2780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00362 CHST6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53428 ZNF791 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77529 GSE224096_1_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.18442 HOXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05563 UBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25092 LTB4R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78145 CSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01652 intracellular organelle GO Cellular Component Annotations 2015 1.0 null PURB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30323 CHD1 ENCODE Transcription Factor Targets 1.0 null CHP126 CCLE Cell Line Gene CNV Profiles 1.0 1.49059 organelle GO Cellular Component Annotations 2015 1.0 null solitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.932201 HLE CCLE Cell Line Gene CNV Profiles 1.0 1.64275 MTHFD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69258 NSMAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70665 VWA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71623 TXNRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57442 143B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.38702 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1108 Reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 MDA-MB-361 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 gigantocellular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12376 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.80201 TMEM140 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31166 FANCI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67412 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.11102 OXER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71094 REP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55643 RNF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37225 C1QBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92318 TSPO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25941 TFAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32401 NSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.29657 NCBP2AS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5464 CTBP2 ENCODE Transcription Factor Targets 1.0 null MT-ND6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93334 MPP89 DepMap CRISPR Gene Dependency 1.0 2.13011 SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.968698 ELL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74334 GAL3ST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20009 MDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10535 hsa-miR-1225-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 RFC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19114 NCIH596 CCLE Cell Line Gene Expression Profiles -1.0 -1.58625 GSE233679_12_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null NFKBIE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50366 F5 DepMap CRISPR Gene Dependency 1.0 4.63112 Gli2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.3303 GSE256181_2_v_0_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null GOSR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05725 MAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5851 UQCRFS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92574 basomedial nucleus (accessory basal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.839462 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83823 COLO668 CCLE Cell Line Gene CNV Profiles -1.0 -1.69027 WSB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0199 MBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96336 DENND1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43056 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.996576 HLA-C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97213 PIK3C2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1175 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SNAI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.1185 NHLH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52824 H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZSCAN26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10153 hsa-miR-1178 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 HPRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07963 superior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.28352 DFCI024 CCLE Cell Line Gene Expression Profiles 1.0 1.63084 VPS11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54107 cytoplasmic part GO Cellular Component Annotations 2015 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.957118 TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.172 inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61172 SAP30 ENCODE Transcription Factor Targets 1.0 null 496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.87815 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RNASE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95184 KINGS1 DepMap CRISPR Gene Dependency 1.0 2.48321 TIGD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43405 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.83459 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UTP23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11912 Calcium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.39 SK-UT-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-3136-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 EFM19 CCLE Cell Line Gene Expression Profiles 1.0 1.73956 SIRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90128 HUS1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90663 ZNF485 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.86183 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27293 SK-MEL-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.876457 RNF44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71965 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null RAB34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54239 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.897437 FAM3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23348 RHOV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88876 CYB5R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42631 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GNG12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.54183 H3C10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01377 ARID4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75743 CCNG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0647 IVD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30347 cingulate gyrus, retrosplenial part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0355 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.83315 GSE196104,GSE196106_2_v_1_vsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ELAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57512 FAM83E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85374 Bone marrow stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.857 WNT5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00829 DLX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98905 TGFBI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66591 SLC16A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51562 TOP3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6302 T173 CCLE Cell Line Gene Expression Profiles 1.0 2.37225 CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.909927 GPM6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32434 FKTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.2239 GTF2A1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25113 HMG20B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91977 NSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53909 prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33193 GSE165636_0_v_4_tofacitinib_human RummaGEO Drug Perturbation Signatures 1.0 null Renal glycosuria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.172 LMAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57896 LARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28371 PLCXD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49493 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59134 structural molecule activity GO Molecular Function Annotations 2015 1.0 null SEMA7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76293 SNU738 CCLE Cell Line Gene CNV Profiles -1.0 -1.71667 BLTP3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45881 P2RX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7402 MATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7278 SCC4 CCLE Cell Line Gene CNV Profiles -1.0 -1.64448 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58746 EGR1 ENCODE Transcription Factor Targets 1.0 null ZNF883 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78362 hsa-miR-1271 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 BARD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72461 ZFP42 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.0006 FBXO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4544 ARHGAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79696 MLXIPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.70456 HNRNPA0 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79512 IBA57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38436 NOP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82855 TRAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81448 NH12 DepMap CRISPR Gene Dependency 1.0 2.07771 Mitochondrial crista junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.739 MLXIPL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7357 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34694 TMEM18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12651 ITM2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73008 SERINC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36153 EZH2_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WWP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89614 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NAA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35186 CTCF ENCODE Transcription Factor Targets 1.0 null ZNF648 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90654 SOCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13741 SZ in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08653 PATU8988T CCLE Cell Line Gene CNV Profiles -1.0 -1.47058 COL1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97412 AFF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30355 SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04089 RRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.64818 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KCNA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0809 HS939T CCLE Cell Line Gene Expression Profiles -1.0 -1.4949 CCDC71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76428 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SKNDZ CCLE Cell Line Gene Expression Profiles 1.0 1.43722 CCDC74B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72895 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HSPB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53726 ITLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.363 WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10621 subthalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08545 STK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80056 Elbow dbGAP Gene-Trait Associations 1.0 0.279697 ANP32B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33643 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4059 PCDHB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17642 Microtome section TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.881 ARID3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.989 HEPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55673 IKBKG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70684 CAL-72 COSMIC Cell Line Gene Mutation Profiles 1.0 null KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.897499 PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0091 NEMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.52002 KLF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.9101 TEX45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14495 subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.931122 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TGFBR3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85664 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.941437 PAFAH1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82857 Nuclear outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.741 COLO-783 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00516 external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06634 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42502 HNRNPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33537 TOR4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69423 MFSD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49941 H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null UHRF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.23322 PDLIM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59669 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12166 H3K27me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GPAT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59735 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.845946 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37086 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAP3K7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05967 ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4634 HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09842 RIPOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11223 chr17_78208610_A_G_b38 GTEx eQTL 2025 1.0 1.07915 MCIXC DepMap CRISPR Gene Dependency 1.0 4.89291 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100409_FWM_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.06621 GSE233679_6_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null red nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04732 ZNF232 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31258 GLO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89491 dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.77709 CENPJ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62373 SLC12A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77894 SLC35E2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99882 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40732 ALX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60578 CCDC142 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54606 EPAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93812 heart disease GWASdb SNP-Disease Associations 1.0 0.944108 WT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2081 MATN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7002 ARL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55874 lateral parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16347 GSE150134_1_v_0_scn5a_human RummaGEO Gene Perturbation Signatures -1.0 null SKIC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31651 DRD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72037 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null FUCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75458 Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.0757 SIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01791 UNG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75456 MBTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93107 ZFAND2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.36448 GSE185519_3_v_7_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null ISCU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38008 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4059 POLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59349 TXNDC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78441 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OXCT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52027 GSE164494_0_v_2_rab22a_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MELHO DepMap CRISPR Gene Dependency 1.0 2.1004 AKAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3765 TRAPPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17918 ENTPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4305 ZNF587 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0891 CPEB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32933 lateral medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.833242 AAR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26333 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SPI1 ChEA Transcription Factor Targets 1.0 null Wt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 72.8849 POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7464 STX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01859 layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.860139 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1514 members GeneRIF Biological Term Annotations 1.0 null deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.986282 NRF1 ENCODE Transcription Factor Targets 1.0 null TMEM145 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85671 LEMD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08439 DIFI DepMap CRISPR Gene Dependency 1.0 3.01225 FOXD4L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60237 SKNO1 DepMap CRISPR Gene Dependency 1.0 2.93719 RAB3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89972 brain GTEx Tissue Gene Expression Profiles 1.0 2.18987 ATIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56334 medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.36065 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null ENTPD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99149 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null Gonad TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 MRPL24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92579 MXI1 ENCODE Transcription Factor Targets 1.0 null OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49529 MYF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7796 MAGI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71159 IMR32 DepMap CRISPR Gene Dependency 1.0 5.76879 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PCDHB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08163 reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23619 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SERF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37184 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13267 H3K27me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GGNBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39014 H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59067 HMGB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11614 MAP3K6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65961 SREBF2 JASPAR Predicted Transcription Factor Targets 1.0 null KIDINS220 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24184 ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3599 MGMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00767 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.832889 GNAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21415 CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.881425 FOXL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74386 zona incerta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.4937 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68721 Male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K56ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE164494_0_v_2_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures -1.0 null VWA5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81596 LRFN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51812 hsa-miR-452 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 SIMA DepMap CRISPR Gene Dependency 1.0 5.65984 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNF145 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38637 ATG16L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66705 CYB5R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18763 GPATCH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74828 MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17764 HSPA1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30301 NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39009 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09964 CILK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.82461 TFDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77876 Ischemic bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.474 HPAF-II Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09964 H3K27me3_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A4FUK CCLE Cell Line Gene Expression Profiles 1.0 1.42854 IFNAR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30471 GSE200673,GSE200691_2_v_4_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC9950457-mmc3.xlsx-GRHL2_overexpression_UP-gene_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null RASIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10377 GSE233679_12_v_4_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null TBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.731 IQCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62971 PLPP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51489 all GWASdb SNP-Phenotype Associations 1.0 0.02896 COLO680N CCLE Cell Line Gene CNV Profiles 1.0 2.02899 HLCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92098 PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null RRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13684 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1864 VMRCLCD CCLE Cell Line Gene Expression Profiles -1.0 -2.83507 H3K27me3_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1115 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GPR25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34926 ADPRH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63399 ZNF285 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49043 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15175 KLM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.79815 PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8 Rummagene Transcription Factor Associations 2026 1.0 null Anchored component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.849 SREBF1 JASPAR Predicted Transcription Factor Targets 1.0 null CXCR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75403 COL4A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48606 CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62905 SELENOO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48604 TBX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29233 Internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE163920_1_v_0_sirt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HS695T DepMap CRISPR Gene Dependency 1.0 2.44094 paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.830414 EMX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87629 GSE176008_4_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null THAP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87073 FITM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84806 D283MED DepMap CRISPR Gene Dependency 1.0 2.67881 PANK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83858 PLS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35146 Ascl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.0649 SAMD4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23147 PKN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66674 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NZM42 DepMap CRISPR Gene Dependency 1.0 2.26077 HTK CCLE Cell Line Gene CNV Profiles -1.0 -1.96844 NT5DC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7047 GPR153 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82721 POU4F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62541 SIN3A ENCODE Transcription Factor Targets 1.0 null CAL-12T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02853 H3K27me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MOB3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56753 H3K27me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.56493 CISH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75015 Interstitial matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.505 ERBB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17583 hsa-miR-769-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 NMUR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88834 MM426 DepMap CRISPR Gene Dependency 1.0 4.84638 NCIH647 CCLE Cell Line Gene CNV Profiles -1.0 -1.86581 ZNF398 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13524 closely GeneRIF Biological Term Annotations 1.0 null 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.46757 NTMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83647 TNNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13726 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896466 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CENPU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05935 ARSK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0095 H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SEPHS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78893 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54922 GSE186124,GSE186128_1_v_0_dnmt3a_human RummaGEO Gene Perturbation Signatures -1.0 null External side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.747 EXOC3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49826 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.930702 HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.897499 NUGC3 DepMap CRISPR Gene Dependency 1.0 4.51195 CBS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45109 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25701 GLCCI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58724 SNU685 CCLE Cell Line Gene CNV Profiles 1.0 1.55231 SNU685 CCLE Cell Line Gene Expression Profiles -1.0 -2.04765 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.843288 KIF13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.91178 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962382 SCRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52449 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.823912 LBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36953 H4K20me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DGCR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.321 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null oral mucosa HPA Tissue Protein Expression Profiles 1.0 1.19416 UMUC9 DepMap CRISPR Gene Dependency 1.0 2.35034 SMARCA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29241 RHOQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70372 RNF207 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42782 P2RX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83389 ZC3H4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50421 DAUDI CCLE Cell Line Gene Expression Profiles 1.0 2.78982 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.312 AGER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2585 ATPAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18833 H3K27me3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TKT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54736 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.028987 H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF2 JASPAR Predicted Transcription Factor Targets 1.0 null GSE174522_1_v_0_spp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null DNAAF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68526 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTAGE15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32053 FUT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90987 MIEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40394 CALM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98828 YY2_KD_GDS3788_490_human_HeLa GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09964 CBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22289 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58543 SNAPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16118 Nr2e3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.0 MEAK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67826 MAPRE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38456 TTLL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71007 TCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1464 OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.915074 ZCCHC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85697 CNIH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9102 membrane GO Cellular Component Annotations 2015 1.0 null ZNF385A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74204 FABP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90457 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NSUN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64496 STX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71861 SLC25A44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10241 KPNA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10501 AP4M1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66808 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF625 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76967 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE207787_1_v_2_pdha1_human RummaGEO Gene Perturbation Signatures 1.0 null C8orf76 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32861 ID3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91639 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null esophagus HPA Tissue Protein Expression Profiles 1.0 1.19416 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.1236 MAP4K3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0307 GFPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44816 Anchored component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.154 I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.861329 CHST10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60999 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KHM1B CCLE Cell Line Gene Expression Profiles 1.0 1.38348 496100550_TCx_no dementia_TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.25805 EPHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38867 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.958504 ZNF768 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.3352 ATG12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76663 upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.06311 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33655 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3423 FAM120A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0513 CELF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85325 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16045 PPM1K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10884 POU4F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63321 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.915074 BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.961301 ZNF143 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53936 ATP11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41444 NCIH3255 CCLE Cell Line Gene Expression Profiles -1.0 -1.51005 KMS28BM CCLE Cell Line Gene Expression Profiles 1.0 1.65011 SALL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8711 DNAJC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20519 UBN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34303 ZNF799 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87542 corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28449 ZNF711 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91274 UBR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81305 GSE185519_3_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null RNF169 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44182 ZFAND4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78681 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42276 SS18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.26742 UQCR10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57224 TDRD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96176 tight junction GO Cellular Component Annotations 2015 1.0 null MIX23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66186 Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.406 MM1S DepMap CRISPR Gene Dependency 1.0 2.23114 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null lateral group of nuclei, left, ventral division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.991447 CL11 CCLE Cell Line Gene CNV Profiles -1.0 -2.2792 H3K27me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MTRFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65947 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.961301 496100626_FWM_no dementia_TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.57372 H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SFT2D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83546 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null OVSAHO CCLE Cell Line Gene CNV Profiles 1.0 1.39538 LATS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05902 GOLGB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12307 HH CCLE Cell Line Gene Expression Profiles 1.0 1.39311 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TSPAN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00599 PEX11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57445 RBPJL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72889 H3K27me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4390530-NIHMS667786-supplement-1.xlsx-Sheet1-Supplementary_Table_2_Genes_closest_to_AR_induced_ASH2L_peaks_AR Rummagene Transcription Factor Associations 2026 1.0 null VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02333 GSE233679_5_v_15_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null DIAPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22831 ZKSCAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20907 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH1915 CCLE Cell Line Gene CNV Profiles 1.0 1.48014 hsa-miR-146b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 EOMES JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2997 SKNAS DepMap CRISPR Gene Dependency 1.0 2.42099 MLX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30642 AGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20013 NUP93 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31976 SRD5A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02544 H3C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98491 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.832889 MASTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43213 Hepatic Cirrhosis_Liver_GSE6764 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.7522 Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.9917 Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.90135 S100PBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06672 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MYOZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.59066 ANXA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7626 PMC11947124-41419_2025_7562_MOESM1_ESM.docx-156-HSF2_HSF2 Rummagene Transcription Factor Associations 2026 1.0 null FDXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78136 CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40732 PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6416 DCUN1D5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82637 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PAX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24687 Claudin InterPro Predicted Protein Domain Annotations 1.0 null ENPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30859 ZNF219 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22365 GSE77108_3_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null plasma membrane part GO Cellular Component Annotations 2015 1.0 null ST18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67022 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null hsa-miR-3168 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 heart muscle HPA Tissue Protein Expression Profiles 1.0 1.19416 CREB1 ChEA Transcription Factor Targets 1.0 null adrenal gland HPA Tissue Protein Expression Profiles 1.0 1.19416 HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.996576 BOLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19253 vacuole LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BEX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36886 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27603 SOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26396 frontal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.58384 VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01664 RAD21 ENCODE Transcription Factor Targets 1.0 null HEV_60Day_None_GSE53731 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.69038 ANKIB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07576 III, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.889185 WASHC2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2585 hsa-miR-1976 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 SPRED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90627 SERPINE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49886 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03078 SPINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3235 ZNF100 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91008 MDAMB361 CCLE Cell Line Gene CNV Profiles 1.0 2.25272 KNS42 DepMap CRISPR Gene Dependency 1.0 4.0277 PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45926 496100596_FWM_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.42993 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.0503 endoplasmic reticulum GO Cellular Component Annotations 2015 1.0 null TCF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98237 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.5432 USP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86281 PMC7825356-8844261.f3.docx-240-TBX10_TBX10 Rummagene Transcription Factor Associations 2026 1.0 null CNOT6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40383 OAW28 CCLE Cell Line Gene Expression Profiles -1.0 -1.56481 EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MORN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15106 APC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26958 BCL7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17247 PRB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29209 PRSS35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2806 CALM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19596 GBA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48598 MYC ENCODE Transcription Factor Targets 1.0 null H3K27me3_CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-1229 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE210885_3_v_7_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PDCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82919 GSE218356_1_v_0_cited1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MARK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26855 CHMP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77188 P63_DEPLETION_GDS2534_63_human_ME180 cervical carcinoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null HOXA10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70854 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28963 HTK CCLE Cell Line Gene Expression Profiles -1.0 -1.48811 lateral habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0148 HES7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51707 HDAC2 ENCODE Transcription Factor Targets 1.0 null SAOS-2 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 GSE256181_1_v_0_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4690-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 NCIH2122 CCLE Cell Line Gene Expression Profiles -1.0 -2.26105 SNU685 DepMap CRISPR Gene Dependency 1.0 3.06933 H3K27me3_iPS-20b Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3204 SLC35E4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77809 EXTL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01755 Rheumatoid arthritis GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.01549 GSTO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87494 MED13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83956 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null USP45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66409 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCMTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66235 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100416_FWM_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.1957 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05753 SND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65202 MRPL58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70361 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HOXB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5376 ZNF501 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59911 reticular nucleus of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.75266 MIXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31527 WARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7417 DBNL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35873 ZNF460 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81345 PPARG JASPAR Predicted Transcription Factor Targets 1.0 null C8166 DepMap CRISPR Gene Dependency 1.0 2.09868 L363 DepMap CRISPR Gene Dependency 1.0 2.42331 IFI30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17322 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.851649 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MMP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17802 CPEB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67631 H3K27me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CC2D1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45305 medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.05299 SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.840616 TBP ENCODE Transcription Factor Targets 1.0 null lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.881489 smooth muscle HPA Tissue Protein Expression Profiles 1.0 1.19416 H3K27me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3861 SUIT-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962382 RAB6D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27261 AQP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68371 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRNP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1317 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53732 ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.867089 H3K27me3_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GRB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63242 JHUEM1 DepMap CRISPR Gene Dependency 1.0 4.0396 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.929796 BHLHE40 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1175 TARBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57594 EZH2_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell junction GO Cellular Component Annotations 2015 1.0 null ABHD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39326 MMP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56132 HDAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61598 TMEM37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34728 HNF4G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43707 SLF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38048 PARP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60652 GSE241402_0_v_1_prmt5_human RummaGEO Gene Perturbation Signatures 1.0 null globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02309 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HELZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55233 I-kappaB/NF-kappaB complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.68 CYP2A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7242 NAGK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52559 EMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05884 WDR83 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87241 ERF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7097 MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5318 Oligosaccharyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.861 ZFP42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.50094 ACVR2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91231 MED16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89232 TRMT10C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57922 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.57212 RUNX3 ENCODE Transcription Factor Targets 1.0 null integral component of membrane GO Cellular Component Annotations 2015 1.0 null ZNF449 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.2594 H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU81 CCLE Cell Line Gene Expression Profiles -1.0 -2.62573 MELJUSO DepMap CRISPR Gene Dependency 1.0 6.44513 MAVER1 DepMap CRISPR Gene Dependency 1.0 2.0159 cell part LOCATE Predicted Protein Localization Annotations 1.0 null hsa-miR-96 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 PKM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85478 PLA2G12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26006 MEF2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71949 CD164 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9396 H3K27me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXO3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10733 TPCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99667 CHP212 CCLE Cell Line Gene CNV Profiles 1.0 2.72852 EPB41L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70584 CDC42EP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30567 KMS34 CCLE Cell Line Gene Expression Profiles 1.0 1.60307 PPP2R5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.13519 POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.61459 PIK3C2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81232 U937 CCLE Cell Line Gene CNV Profiles -1.0 -3.21048 MEST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44312 DNAJA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83046 Rheumatoid Arthritis DisGeNET Gene-Disease Associations 1.0 null MIS18A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22488 NUDT17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6917 cell part GO Cellular Component Annotations 2015 1.0 null OCEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56519 TSPAN14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40616 127399 DepMap CRISPR Gene Dependency 1.0 3.03798 IQGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46925 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain_CT2_Oligo L5-6 OPALIN LDLRAP1 HuBMAP ASCT+B Augmented with RNA-seq Coexpression 1.0 null ZNF683 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13062 PCDHB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92823 HO1U1 DepMap CRISPR Gene Dependency 1.0 2.879 RHNO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33069 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.066043 EP300 ENCODE Transcription Factor Targets 1.0 null STAT3-18555785-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BCLAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91938 NLE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51904 AP5B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41416 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null NFE2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62907 KDM4A ENCODE Transcription Factor Targets 1.0 null CTDNEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78223 BHLHE40 ENCODE Transcription Factor Targets 1.0 null Serum metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.0 SPRY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92966 MXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.1354 occluding junction GO Cellular Component Annotations 2015 1.0 null 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.09047 LAYN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2792 DEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73116 H3K27me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MCU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73707 ANKLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04397 FBXW9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64366 CWC25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14796 PPP1R12C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11342 H2AFZ ENCODE Transcription Factor Targets 1.0 null parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38323 demonstrate GeneRIF Biological Term Annotations 1.0 null Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.7675 PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null GLG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81605 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.65508 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10081 medial parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.923284 ZNF528 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.0292 H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.876848 PHOX2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24729 PLOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68781 GAS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99003 CDK18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39105 CDCA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38089 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21913 SLC27A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02024 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01784 subunit GeneRIF Biological Term Annotations 1.0 null SLC45A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20552 H2BC15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07314 WASF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39964 BCKDK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04994 SELENOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8321 STAT3 ChEA Transcription Factor Targets 1.0 null PJA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24272 cell-cell junction GO Cellular Component Annotations 2015 1.0 null PGBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28769 RAB5IF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12162 H3K27me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SLR23 DepMap CRISPR Gene Dependency 1.0 2.20182 PSMG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2836 PMC9576445-IJG2022-9264555.nxml--Potential_targets_of_hsa-miR-15b-5p_AND_hsa-miR-184_NOT_hsa-miR-16-5p_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null H3K36me3_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896466 MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.865925 LI7 CCLE Cell Line Gene Expression Profiles -1.0 -1.56785 CTTNBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76967 ZNF723 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55487 ZDHHC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00998 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KIF22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33122 BLOC1S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68749 HID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49674 CPHXL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63257 RELA_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.859037 FLT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12507 PMP-22/EMP/MP20/Claudin superfamily InterPro Predicted Protein Domain Annotations 1.0 null NR2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6048 BACH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79532 ERBB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02293 GSE233679_5_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Mayer-Rokitansky-Kuster-Hauser syndrome type 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.494 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CFAP298 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50696 NCIH2172 CCLE Cell Line Gene Expression Profiles -1.0 -1.45397 MPZL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.388 GSE229468,GSE229471_0_v_1_znf587_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1694 CCLE Cell Line Gene Expression Profiles 1.0 1.63153 ERI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60162 ZC3H14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35068 NCIH69 CCLE Cell Line Gene Expression Profiles -1.0 -1.58299 Female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Prdm5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.4568 U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.6446 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHOS4 CCLE Cell Line Gene CNV Profiles 1.0 1.42353 TEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40646 YWHAG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66729 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 GALNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89371 basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15111 ventral tegmental area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.882926 NABP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05339 EFM19 DepMap CRISPR Gene Dependency 1.0 6.11876 ETV4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2448 PRMT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01492 MEGF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86926 CAPAN1 CCLE Cell Line Gene CNV Profiles -1.0 -1.35578 C1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1182 CAB39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76903 SNU886 CCLE Cell Line Gene Expression Profiles -1.0 -1.7996 LIMK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97895 RNF135 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71105 AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962382 NES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40166 SLC17A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45532 LHX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61447 WSUDLCL2 CCLE Cell Line Gene Expression Profiles 1.0 2.08 lateral group of nuclei, left, dorsal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.829558 MOSMO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86251 MAP3K14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45406 gracile nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.921935 H3K27me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Apical part of cell COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 CLASP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58445 PRDM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8499 HCC2218 CCLE Cell Line Gene CNV Profiles 1.0 1.53185 RCBTB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49272 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03656 ATXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30338 SG in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.946618 DGCR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51886 COGN305 DepMap CRISPR Gene Dependency 1.0 3.7876 ZNF609 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60899 KDSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94234 TMSB4Y CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88702 FKBP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82367 KCTD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47706 MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04346 KIAA1586 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68564 GSE154577_6_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null NPTXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2339 ARHGEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45699 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEP192 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13306 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TBX20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12984 inferior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.878926 ACADVL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13444 GOLGA8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80561 pallidohypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25544 RNF114 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11493 PLPPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79447 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0185 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.876457 PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT Rummagene Transcription Factor Associations 2026 1.0 null P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 2.33241 BTBD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47552 TRAPPC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04592 MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LYRM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26797 Testis TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PACSIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76624 SALL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82052 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04246 MFN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29553 tmem114 GeneRIF Biological Term Annotations 1.0 null USP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0381 CES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87037 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Duodenum Mucosa Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.824034 inner CP in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.904932 TC205 DepMap CRISPR Gene Dependency 1.0 2.64429 HMG20A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64166 COLO205 CCLE Cell Line Gene Expression Profiles 1.0 1.78231 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GNPTAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64582 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.18674 RAP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7047 gallbladder HPA Tissue Protein Expression Profiles 1.0 1.19416 TGOLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.59612 TMEM39B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43601 NOTCH_INHIBITION_GDS2794_61_human_MOLT4 (T-cell acute lymphoblast leukemia) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRD5A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.9482 S100A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51074 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139239_3_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.53241 KIF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91861 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.6692 AGXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47511 hsa-miR-486-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 NMB DepMap CRISPR Gene Dependency 1.0 2.00486 DHRS4L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3019 ELAVL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71096 HS737T CCLE Cell Line Gene Expression Profiles -1.0 -1.49174 Muscle - Skeletal GTEx Tissue Gene Expression Profiles 2023 1.0 3.86642 TWIST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.28853 SMARCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14499 POLR2A ENCODE Transcription Factor Targets 1.0 null EIF3M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48352 ARHGEF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38866 SCG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09765 HCC1419 CCLE Cell Line Gene Expression Profiles 1.0 1.61844 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16431 hsa-miR-665 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1514 WASHC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93155 QPCT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41321 CEP85 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35077 ONCODG1 CCLE Cell Line Gene CNV Profiles 1.0 1.99801 Brain_CT2_Oligo 48 HuBMAP ASCT+B Augmented with RNA-seq Coexpression 1.0 null VAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07787 STPG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37937 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.83015 NCIH358 DepMap CRISPR Gene Dependency 1.0 2.01844 ZNF582 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16346 NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58543 RBM46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64875 frontal pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29367 ZNF599 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81054 SLC18A3_KD_GDS4325_618_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null OVISE CCLE Cell Line Gene CNV Profiles -1.0 -1.68076 CAPNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05712 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDUFA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00031 DNAL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17391 GPR143 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07136 ZBTB33_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.56576 M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60239 SKCO1 CCLE Cell Line Gene CNV Profiles 1.0 1.95831 TMEM106B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7075 dependent GeneRIF Biological Term Annotations 1.0 null CPT1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37841 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.575 CAL148 CCLE Cell Line Gene Expression Profiles -1.0 -1.6334 GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null Plasma membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7817 MEIS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77985 RINL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00275 HCC1162 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.996576 KLHL42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98863 MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54922 MAP7D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88292 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.79941 TAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01718 GABPA ENCODE Transcription Factor Targets 1.0 null PRPS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05201 abnormality of cardiac morphology GWASdb SNP-Phenotype Associations 1.0 0.831588 H3K27me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30194 C1GALT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36855 SYCP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11375 RBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99555 CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null MCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01003 SUM149PT DepMap CRISPR Gene Dependency 1.0 2.29962 Small Intestine - Terminal Ileum GTEx Tissue Gene Expression Profiles 2023 1.0 2.75693 MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNF214 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82647 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.81505 CD24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7951 KTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71381 paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.70135 SCC9 CCLE Cell Line Gene CNV Profiles 1.0 1.5039 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.051509 SNX16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49139 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3391 WWC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67985 HLE COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.842053 STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16226 SKIDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02125 H3K27me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCIH647 DepMap CRISPR Gene Dependency 1.0 3.3245 hsa-miR-324-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Prdm14 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.3224 ZNF382 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.4419 PLK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1215 CYP51A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5432 SPAG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38639 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null subcuneiform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.834559 CUL4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.45047 CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22348 LLGL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36294 THEM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88385 NOA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25159 PPP1R35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82052 ZNF669 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9 ADSS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74564 SHFL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60002 TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09842 central medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.88685 SLC25A29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24797 DUXA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89598 KMS12BM CCLE Cell Line Gene CNV Profiles -1.0 -1.78171 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null SH3GL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0975 JVM2 CCLE Cell Line Gene Expression Profiles 1.0 1.87404 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null