association	dataset	threshold value	standardized value
deafness	MGI Mouse Phenotype Associations 2023	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3162
UNCX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03863
RARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41922
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71709
abnormal retina morphology	MGI Mouse Phenotype Associations 2023	1.0	null
RABEP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98313
SNF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08996
GSE133213_6_v_1_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7115
GSE101239_3_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MAX::MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0476
LARP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94568
ARL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55874
Tyrosine metabolism	KEGG Pathways 2026	1.0	null
TLX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76489
hyperactivity	MGI Mouse Phenotype Associations 2023	1.0	null
MRS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62029
EEF2K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69715
GALR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00574
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6242
RETREG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51505
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.576
TRIM24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7488
MBD3L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05735
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2986
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.0709
CTNNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30397
BOLA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48403
ACBD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71977
NPAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21727
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ANKRD33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60958
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4181
TMEM249	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78058
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	1.0	null
CERS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2097
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1827
RAB38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8608
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.772
OSBPL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24545
SINHCAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77418
inner ear receptor cell development	GO Biological Process Annotations 2025	1.0	null
GSE195663_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1984
HSFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17109
GSE101239_3_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ARSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0095
CENPV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24541
DUSP26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56904
CES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87037
impaired balance	MGI Mouse Phenotype Associations 2023	1.0	null
KIF20A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53773
BAZ1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55682
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7275
catecholamine metabolic process	GO Biological Process Annotations 2025	1.0	null
ZFP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79605
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.855
SUCO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82469
NFU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46613
sensory perception of mechanical stimulus	GO Biological Process Annotations 2025	1.0	null
ZNF480	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05141
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6303
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HTR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9434
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DUSP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48641
TAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80409
ZNF124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75582
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7509
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.897
SPAG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38639
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.428
LYRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48078
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5171
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_14_v_12_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53666
CNTRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85191
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6856
SWSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87919
BFAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36672
GSE126402_1_v_7_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.4537
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3666
CARNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70561
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8788
MLX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30642
CPNE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46492
FGD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35666
TMEM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47065
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8548
FKBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55283
NECAB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5742
GSE102598_1_v_2_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
APBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27284
LARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28371
TTC32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89846
ENTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96479
CYP2A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7242
ZNF549	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22694
NSUN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90969
CACNG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50749
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dopamine catabolic process	GO Biological Process Annotations 2025	1.0	null
GSE107505_0_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BMAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6874
PLEKHG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11155
catechol O-methyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
PLAGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0719
BMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77752
GSE132759_4_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PDHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81637
Steroid hormone biosynthesis	KEGG Pathways 2026	1.0	null
MGME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18126
UBL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93928
bidirectional circling	MGI Mouse Phenotype Associations 2023	1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POMGNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21545
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UQCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67624
KIAA0930	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83791
KIF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78909
CAPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30982
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1537
ARMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19684
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1978
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.958
AGRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95411
GSE86507,GSE86509_3_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0783
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.102
OXTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25502
RAB3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89972
abnormal orientation of cochlear hair cell stereociliary bundles	MGI Mouse Phenotype Associations 2023	1.0	null
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4012
GSE126402_2_v_7_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144745_0_v_1_mettl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9213
ZNF208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6389
THAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6352
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0851
Autosomal recessive nonsyndromic hearing loss	ClinVar Gene-Phenotype Associations 2025	1.0	null
GSE145249_0_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
inner ear auditory receptor cell differentiation	GO Biological Process Annotations 2025	1.0	null
EIF4E2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98274
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0242
TGFB1I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33031
SEC11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15685
TMEM94	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05046
E2F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9941
ERBIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67811
GSE126402_4_v_7_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ACBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13581
KIAA1958	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10464
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1364
auditory receptor cell development	GO Biological Process Annotations 2025	1.0	null
CEBPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71397
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.171
REEP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05389
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1867
MROH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87035
MRPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5755
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2625
H3-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73527
ZNF783	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46874
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8902
AGER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33246
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.2007
MAP3K6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65961
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SRRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95326
MAPKAPK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26128
CRISPLD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73289
ATF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.165
GSE145915_0_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2BC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59098
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3307
cochlear ganglion degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0495
abnormal skin coloration	MGI Mouse Phenotype Associations 2023	1.0	null
TBX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91655
absent startle reflex	MGI Mouse Phenotype Associations 2023	1.0	null
biogenic amine catabolic process	GO Biological Process Annotations 2025	1.0	null
GTF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90221
GSE180951_6_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cochlear outer hair cell degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
PMC8027222__F6	PFOCR Pathway Figure Associations 2024	1.0	null
MAGOHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26018
ZUP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56553
ZNF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7203
SETBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15779
ZNF764	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26413
GSE180951_6_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DHX58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5791
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF735	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03014
TNFRSF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28211
PREP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98091
organ of Corti degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17024
NUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56068
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0313
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6736
ZNF239	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73922
ANKRD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.57371
sensory perception of sound	GO Biological Process Annotations 2025	1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.9964
SHISAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63327
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0982
EBAG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73732
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1369
increased or absent threshold for auditory brainstem response	MGI Mouse Phenotype Associations 2023	1.0	null
LMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64908
CTSZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68006
PGM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84771
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE248858_5_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SNX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56141
PHF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60161
GSE95685_4_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H2BC12L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18198
MRPL36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04811
CERS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57571
PGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00628
S1PR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66414
GSE112762,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4123
CACFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78009
LARP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24247
GSE223334_1_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DPY30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28789
AIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06675
ZNF454	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22296
increased aggression towards male mice	MGI Mouse Phenotype Associations 2023	1.0	null
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0725
TTC38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46131
DPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86726
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2377
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1079
ICAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89788
Arntl	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.083
NDUFS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5249
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5851
ZNF396	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75907
BID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18601
GSE166169_0_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
head tossing	MGI Mouse Phenotype Associations 2023	1.0	null
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.525
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1879
KDM4F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37813
RAB3GAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58578
SMARCA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82628
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5722
Dopaminergic synapse	KEGG Pathways 2026	1.0	null
ERLIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90523
PMC7685174__F1	PFOCR Pathway Figure Associations 2024	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.0408
dopamine metabolic process	GO Biological Process Annotations 2025	1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.3546
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.0993
SDR39U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52272
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.9101
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6417
decreased body weight	MGI Mouse Phenotype Associations 2023	1.0	null
INTS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66063
cochlear inner hair cell degeneration	MGI Mouse Phenotype Associations 2023	1.0	null
CCNJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31669
GSE182680,GSE182683_0_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
catecholamine catabolic process	GO Biological Process Annotations 2025	1.0	null
OPLAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65888
GSE169155_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5886
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8781
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
SLC31A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96938
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9423
catechol-containing compound catabolic process	GO Biological Process Annotations 2025	1.0	null
ZNF517	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43137
absent distortion product otoacoustic emissions	MGI Mouse Phenotype Associations 2023	1.0	null
PFKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27299
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3788
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3124
SDHAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79703
abnormal retina blood vessel morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE218580_1_v_0_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3855
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15795
CH25H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24383
ASXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23051
SPINDOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78715
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.1553
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3933
THEM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72522
LHX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61447
GULP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25546
GSE123022,GSE123030_8_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.6923
PRNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37635
S-adenosylmethionine-dependent methyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2562
SAAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29836
TSHZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75582
MBOAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36822
O-methyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1416
SALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55568
LIG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29009
COL9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07272
ZNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98484
EFNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96275
NAIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3737