association dataset threshold value standardized value MIIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11726 In situ melanoma of skin_Epidermis_GSE4587 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.39267 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14618 H3K27me3_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A8CY-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Median nucleus of thalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.921 POU5F1-18700969-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE192771_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.009417 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TD-01A-51R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pyramidal layer of taenia tecta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34895 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUGC4 CCLE Cell Line Gene CNV Profiles 1.0 1.73023 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE159893_2_v_0_genistein_human RummaGEO Drug Perturbation Signatures 1.0 null EP300_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null torsina GeneRIF Biological Term Annotations 1.0 null YY1-26981420-C2C12-MOUSE-MUSCLE ChEA Transcription Factor Targets 2022 1.0 null TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.674878 hematopoietic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054451 globose nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.60709 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28336 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gastrointestinal anthrax DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.231 superficial stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55459 GSE127790_10_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1534 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.837342 BCLAF1 ENCODE Transcription Factor Targets 1.0 null GSE157555,GSE157556_0_v_6_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13802 Ebolavirus(ZEBOV)_1day_Spleen_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.2441 SRF-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null RBM48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34538 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null purine nucleoside binding GO Molecular Function Annotations 2015 1.0 null GSE164521_0_v_1_nitric oxide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Accessory olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.68707 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055326 Lung squamous cell carcinoma_LUSC_TCGA-63-6202-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADAM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09173 7441_RPL17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.756533 posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16426 KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.862491 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null 4959_MED9_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.587055 Marrow cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL120 CCLE Cell Line Gene Expression Profiles -1.0 -1.79026 GSE143994_0_v_1_ythdf1_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12865_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01932 PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null TAF7L-23326641-C3H10T1-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BD-A2L6-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.836362 THAP11-20581084-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231648_4_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null NUP85 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0085 CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY ChEA Transcription Factor Targets 2022 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06933 Perturb_15748_KO_Thap11_SRP065965 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.7172 Nucleus of the lateral lemniscus, horizontal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94825 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4700-01A-02R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null heart_5a HPA Tissue Sample Gene Expression Profiles -1.0 -0.879285 KDM1A ENCODE Transcription Factor Targets 1.0 null CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Eastern equine encephalitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.343 heart_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.37075 RNF31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39298 newly GeneRIF Biological Term Annotations 1.0 null u138mg HPA Cell Line Gene Expression Profiles -1.0 -0.911507 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Episodic ataxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.365 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.857916 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01539 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07851 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.972693 Interanteromedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00133 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.951233 7251_RFFL_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.653884 PPP1R14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59022 E2F4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.397716 ZNF331 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.4163 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.951163 cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.942889 ChIP_CTCF_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE157555,GSE157556_3_v_2_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null positive regulation of gene expression GO Biological Process Annotations 2025 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.10479 beta GeneRIF Biological Term Annotations 1.0 null GSE88819_6_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Mononuclear cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Kidney Failure, Acute DisGeNET Gene-Disease Associations 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null pretectal region Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.982633 purine ribonucleotide binding GO Molecular Function Annotations 2015 1.0 null Apical plasma membrane urothelial plaque COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.718 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15058 MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262717 RAD21_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF2BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41058 cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null ChIP_POU5F1_18700969 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null lateral hypothalamic area, tuberal region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03121 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.91017 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-C5 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.73628 AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.304805 SIX5_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.684 2907_FAM216A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.548512 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.88506 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE60691_2_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null tyrosine GeneRIF Biological Term Annotations 1.0 null SRF-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 20460173-ImmPortCytokines GeneSigDB Published Gene Signatures 1.0 null ZMYM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51593 synthesized GeneRIF Biological Term Annotations 1.0 null abnormal glucose homeostasis GWASdb SNP-Phenotype Associations 1.0 0.17844 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Mononuclear phagocyte TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.72627 CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43285 HNF4G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88633 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nuclear inner membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.557 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.45649 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3409-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null macromolecular complex subunit organization GO Biological Process Annotations 2015 1.0 null Plasma membrane CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.664 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.445498 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE183251_4_v_6_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null REST JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.3983 COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03132 EE-98-PF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240535 6845_PSMA5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.853107 ZEB1 ENCODE Transcription Factor Targets 1.0 null NANOG_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Field CA1, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22375 primary auditory cortex (core)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.66707 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.877354 SNU1214 CCLE Cell Line Gene CNV Profiles 1.0 2.47511 Ovarian Neoplasm DisGeNET Gene-Disease Associations 1.0 null V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.195 HEC59_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 2.91253 abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.31167 dorsolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.829225 T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885333 GSE172490_5_v_3_junb_mouse RummaGEO Gene Perturbation Signatures -1.0 null nucleoside phosphate binding GO Molecular Function Annotations 2015 1.0 null OB-06-WW76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.416427 EFO-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8945 Type I spiral ganglion neuron_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null potent GeneRIF Biological Term Annotations 1.0 null GSE184892_6_v_3_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.62797 outer CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00879 TMEM183A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67415 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10311 SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-91-WB95_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.293839 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26265 GSE178227_1_v_2_tet1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ClpA/B family InterPro Predicted Protein Domain Annotations 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.868157 GSE112860_5_v_4_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null THP-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.1421 Synaptic vesicle, recycling pool COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.124 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HF-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Becker Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.3231 periventricular stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53552 Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18533 RXRA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null HL-60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.949296 ZNF253 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21163 SPPL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08153 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.84534 POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.17374 IGR1 CCLE Cell Line Gene CNV Profiles -1.0 -1.47049 CTCF_GM12801_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE247775_1_v_0_tmprss2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4749-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.17476 dorsal raphe nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.880967 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.297 H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MEAK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11143 hsa-miR-1205 TargetScan Predicted Conserved microRNA Targets 1.0 0.175726 GSE230656_0_v_1_gsdmd_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null coronary artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.687184 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52129 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.913226 EIF3M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00024 Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29716 Embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null RARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.0 CTCF_GM12870_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null isthmic part of the intermediate lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16564 GSE169205_4_v_7_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null JW 480 DeepCoverMOA Drug Mechanisms of Action 1.0 0.36 SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067746 hsa-miR-608 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27967 GSE203308_9_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PC-80-LV29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256921 HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.906262 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.869155 GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.898532 PATU8988T_PANCREAS CCLE Cell Line Proteomics 1.0 3.65825 RPL36AL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18353 GSE202134_0_v_1_rbm39_human RummaGEO Gene Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09699 SKCO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.39388 JHH1 CCLE Cell Line Gene Expression Profiles 1.0 2.39486 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.983655 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17715 SK-MM-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.29623 AD-18-XC14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.240623 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAVER1 DepMap CRISPR Gene Dependency 1.0 2.04991 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.79453 20032505-TableS5 GeneSigDB Published Gene Signatures 1.0 null MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.43504 cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null GSE131798,GSE131804_2_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null r10 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00133 t47d HPA Cell Line Gene Expression Profiles 1.0 1.0603 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE218907_3_v_2_opa1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null D-3263 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.26 OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.309855 Primary somatosensory area, lower limb, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02491 GSE144115_4_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.927395 SUMO1 Pathway Commons Protein-Protein Interactions 1.0 null cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.335412 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22412 GSE183251_1_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null 8157_SMC3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.534852 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14891 antimicrobial humoral immune response mediated by antimicrobial peptide GO Biological Process Annotations 2025 1.0 null SMARCB1 ENCODE Transcription Factor Targets 1.0 null lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26968 FOXA1 ENCODE Transcription Factor Targets 1.0 null 496100669_FWM_no dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.14978 PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null nucleus subceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.970816 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.01201 POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null S117 DepMap CRISPR Gene Dependency 1.0 2.06945 SPI1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null placenta_6c HPA Tissue Sample Gene Expression Profiles 1.0 0.838466 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE255432_6_v_0_imeglimin_mouse RummaGEO Drug Perturbation Signatures -1.0 null WC-59-RG09_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.441348 PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-125a-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.27815 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST ChEA Transcription Factor Targets 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.86685 NDUFB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48778 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null EZH2-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SNCA Pathway Commons Protein-Protein Interactions 1.0 null Hematopoietic cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 lateral wings of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04124 GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null KMS11 CCLE Cell Line Gene Expression Profiles 1.0 1.64692 membrane-enclosed lumen GO Cellular Component Annotations 2015 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.92456 r3 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57493 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11576_KO_Zip8_SRP344283 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.53636 SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null translated GeneRIF Biological Term Annotations 1.0 null GSE180147_0_v_1_itga5_human RummaGEO Gene Perturbation Signatures 1.0 null DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208246 AE-61-UO01_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225885 RKO-E6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11752 hsa-miR-24 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF Rummagene Transcription Factor Associations 2026 1.0 null DA-35-DU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209426 CTCF_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GCM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7792 CORL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.41009 MDAMB157 CCLE Cell Line Gene CNV Profiles -1.0 -2.72009 GSE220287_2_v_1_mef2d_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE231648_1_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.6607 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NFATC1 ENCODE Transcription Factor Targets 1.0 null SPI1_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.1931 CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE196540,GSE196542_4_v_3_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12481 cSARS Bat SRBD_36Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.6732 BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.787326 mcf7 HPA Cell Line Gene Expression Profiles 1.0 1.43998 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HSMM Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.964624 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38288 SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.904696 CTCF-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MF-11-EW49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287615 arteries GeneRIF Biological Term Annotations 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JURLMK1 CCLE Cell Line Gene CNV Profiles -1.0 -2.15129 PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mutant GeneRIF Biological Term Annotations 1.0 null EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NB-61-FT12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.246354 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null rh30 HPA Cell Line Gene Expression Profiles -1.0 -1.32803 Cardiomyopathy DisGeNET Gene-Disease Associations 1.0 null HS 695T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.77005 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Organism form TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MBTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2862 FB-66-UU47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.24887 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.94343 GSE255432_4_v_0_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042303 PMC6977700-aging-12-102667-s006..xlsx-Sheet1-The_identified_1173_dysregulated_LmiRM-CTs_in_MI_using_our_method_MITF Rummagene Transcription Factor Associations 2026 1.0 null peptide hormone secretion GO Biological Process Annotations 2025 1.0 null THAP1 ENCODE Transcription Factor Targets 1.0 null MYT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33786 Sickle cell disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 Parkinson Disease DisGeNET Gene-Disease Associations 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null m1Lim part of the midbrain reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29637 CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.09458 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.10877 SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16847 GSE196540,GSE196542_2_v_5_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null REST ENCODE Transcription Factor Targets 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.028055 DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.22749 dorsolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35549 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE121043_0_v_1_aldh1a1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_7_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null NCIH1573 CCLE Cell Line Gene CNV Profiles -1.0 -1.32859 Hyperplasia CTD Gene-Disease Associations 1.0 1.59778 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.258082 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE127790_4_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE224742_0_v_1_slc1a5_human RummaGEO Gene Perturbation Signatures 1.0 null hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.296571 Brain Lower Grade Glioma_LGG_TCGA-DB-A4XE-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6477-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null parasubthalamic nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55243 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null circulating GeneRIF Biological Term Annotations 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.463398 antibacterial GeneRIF Biological Term Annotations 1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1276 CDH4-35650610-MESC-MOUSE-STEM-AUTISM ChEA Transcription Factor Targets 2022 1.0 null orbital frontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23859 PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-652-ENSG00000196152_ZNF79 Rummagene Transcription Factor Associations 2026 1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16595 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-61 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.15541 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.65111 MARCKSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12024 CTV1DM DepMap CRISPR Gene Dependency 1.0 2.12104 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE103122_0_v_1_riok3_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02584 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Infralimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05256 ChIP_TCF3_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SIN3B-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null antimicrobial GeneRIF Biological Term Annotations 1.0 null GSE141726,GSE141733_1_v_0_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures 1.0 null HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885333 Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38989 POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.333608 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null GSE95077_1_v_0_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null SIN3B ChEA Transcription Factor Targets 1.0 null Intracellular organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 mantle zone of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20521 Ventromedial hypothalamic nucleus, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21957 GCT CCLE Cell Line Gene Expression Profiles -1.0 -1.8132 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 'de novo' posttranslational protein folding GO Biological Process Annotations 2015 1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4763-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K20me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055281 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A61B-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.891851 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null MYOD1 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AU-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_358_KD_SIRT5_SRP311327 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 10.9451 ZSWIM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47728 H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-875-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GTEx Breast 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures -1.0 -3.81383 GSE113106_0_v_4_dnm2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null DMRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29841 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12686 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL2 ENCODE Transcription Factor Targets 1.0 null MV-4-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.66487 BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.363816 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54229 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2722-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NTERA2CLD1 DepMap CRISPR Gene Dependency 1.0 2.02042 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27873 Segmental dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.542 FOXM1 ENCODE Transcription Factor Targets 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12522 DUS1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18371 SPI1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null spleen_3b HPA Tissue Sample Gene Expression Profiles 1.0 1.06512 GSE178227_1_v_0_tet1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE114883_1_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE206270_2_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53788 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null posterior group of nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08414 H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Lung adenocarcinoma_LUAD_TCGA-53-A4EZ-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.520522 DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28336 CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Oligodendroglioma_CNS - Brain (MMHCC)_GSE2223 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.59945 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055384 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Multiple Sclerosis, Relapsing-Remitting DisGeNET Gene-Disease Associations 1.0 null RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null vascular smooth muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.702308 BXPC3_PANCREAS CCLE Cell Line Proteomics 1.0 2.84343 CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2019 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05491 Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885333 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11593 TMEM208 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03857 GATA5_KO_GDS4809_170_mouse_Lung GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7832-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Torsin InterPro Predicted Protein Domain Annotations 1.0 null superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15763 COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08619 primary auditory cortex (core)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25468 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VL-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE95077_1_v_2_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-330-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.14995 GSE132386_2_v_0_ppara_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4706 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE230744,GSE237803_5_v_3_hira_human RummaGEO Gene Perturbation Signatures -1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6906-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null within GeneRIF Biological Term Annotations 1.0 null 11823860-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 4.42991 QB-42-MC63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.284814 Eyelid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.286 dorsal terminal nucleus of the accessory optic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24749 Lung squamous cell carcinoma_LUSC_TCGA-39-5036-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13646 adult stem cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08473 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18099 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null GSE127790_6_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.121844 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27064 BC-13-OQ01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201494 superficial stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4806 CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null leukocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210655_3_v_7_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null XRN2 ChEA Transcription Factor Targets 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.37733 NP8 DepMap CRISPR Gene Dependency 1.0 2.24434 E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Asimadoline DeepCoverMOA Drug Mechanisms of Action -1.0 -0.54 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00362 HHUA DepMap CRISPR Gene Dependency 1.0 2.0375 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lymphoid tissue TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-58-8387-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5966-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2966_FANCI_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.605403 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055726 GSE162739_4_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null GSE146982_7_v_5_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null ADA complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.774 GSE196540,GSE196542_4_v_0_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRR12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58071 SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anteroventral periventricular preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03833 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GEMIN8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20256 CTCF ChEA Transcription Factor Targets 1.0 null THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2014 coronary atherosclerotic plaque TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.28412 GSE167474_1_v_3_naa40_human RummaGEO Gene Perturbation Signatures -1.0 null tunica intima vasorum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.639281 GB-06-BA49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.961438 MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endoplasmic reticulum LOCATE Predicted Protein Localization Annotations 1.0 null CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carcass TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.28 GSE245270_1_v_0_isoproterenol_human RummaGEO Drug Perturbation Signatures 1.0 null surrogate GeneRIF Biological Term Annotations 1.0 null H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.80306 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.25071 BB-20-UU03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.224828 PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_filtered-genes_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null GSE234637_3_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_Activation - 24 hours_GDS2025_726_mouse_Pancreatic islet beta cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2989 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.944184 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.903455 KDM5B ENCODE Transcription Factor Targets 1.0 null ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.9989 GSE147210_3_v_5_kmt2d_mouse RummaGEO Gene Perturbation Signatures -1.0 null ERG ChEA Transcription Factor Targets 1.0 null r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26073 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.02485 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.350938 SF3B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38785 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.94584 Endothelial Dysfunction DisGeNET Gene-Phenotype Associations 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HS172T CCLE Cell Line Gene Expression Profiles -1.0 -1.69864 Liver Diseases CTD Gene-Disease Associations 1.0 1.09047 Orbital area, medial part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39573 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.84023 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.83136 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.875533 cellular component assembly GO Biological Process Annotations 2015 1.0 null Idiosyncratic drug effect_Hepatic Tissue_GSE2825 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.81916 RXRA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-542-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CTCF_WI38_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1299 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 XRN2-22483619-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HNT-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.829025 RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rotigotine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.49 H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051965 GSE229344_2_v_0_cyb5r3_human RummaGEO Gene Perturbation Signatures -1.0 null SKMEL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.40425 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050662 Get-1_Deficiency_GDS2629_161_mouse_embryonic skin GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.936509 r2 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62739 artery wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.425392 ZNF630 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00133 CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE196962_2_v_1_parg_human RummaGEO Gene Perturbation Signatures -1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null magnocellular superficial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17582 lateral medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.834602 GSE154246_2_v_0_haspin_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.955504 H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050723 hsa-miR-138-5p MiRTarBase microRNA Targets 1.0 null GSE201217_4_v_6_usf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE223334_3_v_0_bcl11b_mouse RummaGEO Gene Perturbation Signatures -1.0 null PXDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25653 HELA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48739 BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.87001 midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.834042 intermediate stratum of DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0513 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null spliced GeneRIF Biological Term Annotations 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.324134 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE199921_1_v_0_romidepsin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZL-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA-63-LW25_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2013 PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE158834_2_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.962365 MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4122 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4651 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE186660_2_v_1_nicotine_mouse RummaGEO Drug Perturbation Signatures 1.0 null E2F1 ChEA Transcription Factor Targets 1.0 null RFX5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04567 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hemodynamics GeneRIF Biological Term Annotations 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiopulmonary GeneRIF Biological Term Annotations 1.0 null PMC4955670__F5 PFOCR Pathway Figure Associations 2024 1.0 null POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ovary GeneRIF Biological Term Annotations 1.0 null Bleb COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.354 CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.30175 PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF Rummagene Transcription Factor Associations 2026 1.0 null CTCF_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 205 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.89651 NANOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11069 NCIH1915 CCLE Cell Line Gene CNV Profiles -1.0 -2.31352 NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.875533 Fibrosis CTD Gene-Disease Associations 1.0 1.35328 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE189683_3_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.918296 HC-01-FD24_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.305853 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25584 UACC812 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.869865 IZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.83078 mouse GeneRIF Biological Term Annotations 1.0 null GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the endocrine system GWASdb SNP-Phenotype Associations 1.0 0.067412 TCF3 ENCODE Transcription Factor Targets 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE181003_1_v_2_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69743 Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE123825_2_v_3_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null SNU1076 CCLE Cell Line Gene CNV Profiles 1.0 2.13016 NOMO1 CCLE Cell Line Gene Expression Profiles 1.0 1.99017 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.4266 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062807 POLR2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65197 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.540781 bonemarrow_6c HPA Tissue Sample Gene Expression Profiles 1.0 1.18496 BC-43-JW95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.224008 Internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 hsa-miR-3614-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 RAD21_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sulforaphane DeepCoverMOA Drug Mechanisms of Action -1.0 -1.14 GSE148066,GSE157787_2_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.90922 RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.8933 BL4155 (USP38) NURSA Protein Complexes 1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 PMC8481886-Table_1.xlsx-A_subsets-iMSC_UC_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null Anacetrapib DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 TTF2-22483619-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null r6 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16801 RFX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1947 ZFX-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE215086_5_v_0_batf_human RummaGEO Gene Perturbation Signatures -1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null placenta BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.10319 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Sepiapterin reductase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.072 CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein complex subunit organization GO Biological Process Annotations 2015 1.0 null GSE142684_3_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.53148 PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null chr9_127733354_C_G_b38 GTEx eQTL 2025 1.0 1.72747 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227836 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.87016 RXRA ENCODE Transcription Factor Targets 1.0 null CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.992564 neuroblastoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.310421 arcuate nucleus of medulla, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.65359 VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE ChEA Transcription Factor Targets 2022 1.0 null H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31265 AMG 487 DeepCoverMOA Drug Mechanisms of Action 1.0 0.38 Nucleoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.691 NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-93-AM31_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215124 striatum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32697 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10324 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A51W-01A-21R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R1-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YD38 CCLE Cell Line Gene CNV Profiles 1.0 1.65565 RH18 CCLE Cell Line Gene Expression Profiles -1.0 -1.46507 bone marrow HPA Tissue Gene Expression Profiles 1.0 1.98582 MYC-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Macrophage_Spleen_Mouse CellMarker Gene-Cell Type Associations 1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.49852 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HO-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.50323 head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE130401_4_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUN-27471255-CHONDROCYTES-MOUSE-RIB ChEA Transcription Factor Targets 2022 1.0 null ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1 ChEA Transcription Factor Targets 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSTM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45666 PMC12178937-mmc6.xlsx-L_MAFF_KDvsL_C_deg_all-gene_id_MAFF Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of r3Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06013 PMC12074931-Table_1.xlsx-Sheet1-NFE2L2_NFE2L2 Rummagene Transcription Factor Associations 2026 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF836 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12397 positive regulation of cAMP-mediated signaling GO Biological Process Annotations 2025 1.0 null Coronary atherosclerotic plaque TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.742 GSE211128_9_v_0_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null PEER CCLE Cell Line Gene CNV Profiles -1.0 -1.98592 GSE240439_1_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null RAD21_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216538_7_v_2_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOXP1_01_88 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59732 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_WI38_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LMO2-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE ChEA Transcription Factor Targets 2022 1.0 null WSU-DLCL2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BE-81-QL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.311309 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SREBF1 ChEA Transcription Factor Targets 1.0 null GSE157555,GSE157556_5_v_1_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064446 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05451 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1276 GA-47-MH68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.79138 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.25231 GSE149903_3_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null Cognition Disorders CTD Gene-Disease Associations 1.0 1.1122 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX10_KO_GDS3480_257_rat_Schwannoma cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null AA-22-UI44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.383444 GSE245270_2_v_0_isoproterenol_human RummaGEO Drug Perturbation Signatures 1.0 null neuroblastoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.219928 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-L4-A4E5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHEMBL1436068 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.34 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14342 Poisoning CTD Gene-Disease Associations 1.0 1.36905 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.92763 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null binding GO Molecular Function Annotations 2015 1.0 null CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6581_POT1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.23354 Subiculum, dorsal part, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13871 GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE182854_2_v_3_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null SIRT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16957 CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-05A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABL1_druginhibition_77_GSE24493 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.9597 r1 part of intermediate nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59286 Lung adenocarcinoma_LUAD_TCGA-97-8171-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.878372 JHH-4 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.28457 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Purkinje cell layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07335 MXI1 ENCODE Transcription Factor Targets 1.0 null 9-Aminocamptothecin DeepCoverMOA Drug Mechanisms of Action 1.0 1.6 SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null principal sensory nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.36766 Lung adenocarcinoma_LUAD_TCGA-62-A46P-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Meige syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.329 hsa-miR-3657 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14656 TOR1AIP1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-4271 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31035 Nucleus of the brachium of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34048 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.165 TAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MV-4-11 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.82516 PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Generalized dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.816 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Diabetes DisGeNET Gene-Disease Associations 1.0 null tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.65121 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE195559_8_v_4_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.890402 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null GSE92364_1_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures 1.0 null periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80681 rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.71749 PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.725 Asthma, allergic_Lung Tissue_GSE3184 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.95586 Movement disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.032 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null bcl11b_18199763_brain_lof_mouse_gpl1261_gds3178 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.778291 SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42317 Left Anterior Descending Coronary Artery Occlusion DisGeNET Gene-Disease Associations 1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.50862 IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.888769 6709_PPY_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.891353 CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null bj HPA Cell Line Gene Expression Profiles -1.0 -0.907244 SIX5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AE-85-KE62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.268644 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6977700-aging-12-102667-s004..xlsx-Stage3-The_identified_641_dysregulated_LmiRM-CTs_in_stage_3_of_MI_1_month_after_MI_using_our_method_MITF Rummagene Transcription Factor Associations 2026 1.0 null Brain - Frontal Cortex (BA9) GTEx Tissue Gene Expression Profiles 2023 1.0 2.79802 r4 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29964 ITPKC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20011 intermediate stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6605 foam cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.464948 QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.322499 GATA3-21867929-CD8-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.939599 SIN3A_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.954532 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.5836 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.982391 TUBG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35604 artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.085053 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OB-06-WW76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.1468 EIF3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38959 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Venezuelan equine encephalitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 apoe GeneRIF Biological Term Annotations 1.0 null bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.420386 Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42151 BL6872 (ALMS1) NURSA Protein Complexes 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05831 PPIL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36765 intracellular organelle lumen GO Cellular Component Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8507-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE129389_0_v_6_tropifexor_mouse RummaGEO Drug Perturbation Signatures 1.0 null SKM1 CCLE Cell Line Gene Expression Profiles 1.0 1.6698 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157555,GSE157556_3_v_7_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.883792 TCF12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H1-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF610 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 89.0214 MAZ ENCODE Transcription Factor Targets 1.0 null H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 'de novo' protein folding GO Biological Process Annotations 2015 1.0 null posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.957171 VAMP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7992 SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23912 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AE-56-RB57_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21203 USF1 ENCODE Transcription Factor Targets 1.0 null ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9635 pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.396392 496100640_PCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.64237 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null culture supernatant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.580818 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38342 S117 CCLE Cell Line Gene Expression Profiles -1.0 -1.74741 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.284728 H3K4me1_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21957 GSE195559_0_v_9_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE165560_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SART3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20539 GSE62843,GSE64371_2_v_5_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null Spinocerebellar ataxia type 6 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.143 RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r5 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15472 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE112860_0_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8435 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A69M-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.44131 estradiol_mus musculus_gpl4134_gse23241 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4224-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.963604 Phenylboronic acid DeepCoverMOA Drug Mechanisms of Action -1.0 -0.3 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.50274 GSE164463_2_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GLIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.2968 HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31284 RFX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0783 NNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0219 Isoproterenol DeepCoverMOA Drug Mechanisms of Action 1.0 0.29 HDAC6 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DD-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null grampositive GeneRIF Biological Term Annotations 1.0 null contribute GeneRIF Biological Term Annotations 1.0 null INCENP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14961 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GP5D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2A ENCODE Transcription Factor Targets 1.0 null anion binding GO Molecular Function Annotations 2015 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LC-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Carcinoma, Hepatocellular_Hepatic Tissue_GSE4612 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.03268 alternatively GeneRIF Biological Term Annotations 1.0 null SW1116 CCLE Cell Line Gene CNV Profiles 1.0 2.1018 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.76804 CEBPB ENCODE Transcription Factor Targets 1.0 null H413 DepMap CRISPR Gene Dependency 1.0 2.09519 RELA ENCODE Transcription Factor Targets 1.0 null anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.10584 VCX3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42043 Locus ceruleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2617 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.65005 GSE98964_1_v_4_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null r3 part of spinal trigeminal sensory column, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05819 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SRY-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PMC9950457-mmc3.xlsx-AP2A_binding_sites_GRHL2_KO-LRRC32_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null chaperone mediated protein folding requiring cofactor GO Biological Process Annotations 2015 1.0 null GSE152432_3_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19901 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hilus of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05256 r4 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37985 CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70771 mantle zone of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29876 19605494-TableS2 GeneSigDB Published Gene Signatures 1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111035,GSE111040_10_v_9_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 8633_SYS1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.589001 GA-88-CF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212142 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27375 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60241 Nuclear lamina COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.341 CTCF_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF4A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50547 9147_TNNT2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.64407 CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.42371 periventricular stratum of r3Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18263 ARF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83908 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20039 Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Infralimbic area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32362 ventrolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.966255 Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Endoplasmic reticulum lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.852582 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AA-46-GL76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.288533 PMC12224833-12967_2025_6787_MOESM3_ESM.xlsx-DEGs_PDX1-GeneSymbol_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.898802 MFE280 CCLE Cell Line Gene CNV Profiles 1.0 1.72426 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 7608_RUVBL2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.505491 USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.841731 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.39256 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null lateral tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18463 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.20055 lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32341 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262782 PD-05-HV36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219995 H3C10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00707 humanderived GeneRIF Biological Term Annotations 1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_7_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null E2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9025 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.56709 CRO-AP2 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.00021 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE249098_1_v_2_mthfd1l_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04534 BC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Subiculum, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02367 FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208582 ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.65881 FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-203-ZNF79_ZNF79 Rummagene Transcription Factor Associations 2026 1.0 null Torsin 1/2 InterPro Predicted Protein Domain Annotations 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE58724_1_v_0_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null D-566MG COSMIC Cell Line Gene Mutation Profiles 1.0 null dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.954503 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.933268 CA-42-YI34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252934 rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.933094 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r6BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00401 SREBP1-19666523-LIVER-FROM-C57BL-MICE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ANKS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02876 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2854 GSE244072_10_v_8_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null ENTREP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31733 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRY ChEA Transcription Factor Targets 1.0 null PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null PAX5_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE232786_1_v_0_otud1_human RummaGEO Gene Perturbation Signatures 1.0 null ESR1_ECC-1_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149901_2_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null Liver Neoplasms CTD Gene-Disease Associations 1.0 1.46595 TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18613 NFYA ENCODE Transcription Factor Targets 1.0 null lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.2533 AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238615 EA-18-FP00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244201 Parasubthalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03104 PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null ribonucleoside binding GO Molecular Function Annotations 2015 1.0 null Perturb_8689_KD_FAT1_SRP358313 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.29776 GSE44157,GSE44163_1_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.44246 sk-n-sh cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.729797 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4713-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_7_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4487 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_12_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null 6071_PARK7_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.74154 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01823 MRPL44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49419 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.43096 RKO-E6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04509 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHOS2_OVARY CCLE Cell Line Proteomics 1.0 4.06096 NR2F2 ENCODE Transcription Factor Targets 1.0 null PMC3371315-NIHMS350140-supplement-13.xls-MCF7-T47D-SK-453_Up_Common_xls-Supplementary_Table_6_Luminal_Signature_Genes_increased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.747292 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149943_2_v_0_cd8a_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null SMC3_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.966345 6889_PSPH_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.759495 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A620-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6652_PPP1R10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.677751 hsa-miR-670 TargetScan Predicted Conserved microRNA Targets 1.0 0.348832 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.955504 GSE149903_0_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.399114 YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.73066 r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.50847 CTCF_MEL cell line_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0704 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.940591 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCI-6A Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.02524 T47D Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.60795 ME1 CCLE Cell Line Gene CNV Profiles -1.0 -2.7547 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.479 GSE226249_5_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null b-lymphocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0841 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A902-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Penis_Foreskin_Melanocyte_Primary_Cells_skin01 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.4775 GSE101112_6_v_4_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null Sensorimotor area TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.681 POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.849634 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DNA polymerase III complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.165 GSE88819_5_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.480519 CC2D1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61403 SARS-dORF6_60Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.3888 Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE136627_2_v_1_hdac4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE225735_0_v_4_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null Blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null Dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10797 Sarcoma_SARC_TCGA-DX-A3LU-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BICR18 CCLE Cell Line Gene CNV Profiles 1.0 3.27623 cell part GO Cellular Component Annotations 2015 1.0 null PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.967421 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47034 caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.885685 CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null NCI-H1436 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.1778 ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9314667-Table_1.xlsx-Regulons-ATF5_ATF5 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GATA-1_KD_GDS1245_81_mouse_megakaryocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.7069 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.17542 TLNRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18445 VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04654 GTEx Lung 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures -1.0 -10.3091 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null ID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02794 GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.839378 ARL4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00681 ALEXANDERCELLS CCLE Cell Line Gene Expression Profiles -1.0 -1.66285 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20189 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -0.87309 Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HIF1A_01_86 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.22373 GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4682 TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 JB-75-NC66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.740317 Nuclear envelope COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 MAFF ENCODE Transcription Factor Targets 1.0 null GSE149264,GSE149267_9_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35264 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.71483 H4K20me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXO1_KD_GDS2720_477_mouse_LSK GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3255 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.52354 SKES1 CCLE Cell Line Gene CNV Profiles 1.0 2.08908 OAW28 CCLE Cell Line Gene CNV Profiles 1.0 2.05093 ventral tuberomammillary nucleus, intermediate part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65876 CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.410058 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34396 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.382 hsa-miR-1909 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.837342 TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null Perturb_11771_KO_10M04Rik_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.34449 H3K27ac_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SF-67-CJ22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249487 TAF1 ENCODE Transcription Factor Targets 1.0 null PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP6V0A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06299 MYC_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.41802 GSE169356_0_v_1_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE131649_4_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null EE-98-PF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.334028 SRF ChEA Transcription Factor Targets 1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r4 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07655 RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.46202 EP300 ENCODE Transcription Factor Targets 1.0 null Ventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44501 CERS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11129 CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.38462 bonemarrow_6a HPA Tissue Sample Gene Expression Profiles 1.0 2.13928 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.44454 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.3699 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r4 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48591 SIX5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214725_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H2AFZ ENCODE Transcription Factor Targets 1.0 null CEBPB-24764292-MC3T3-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BE-66-UB12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.27854 vasopressin secretion GO Biological Process Annotations 2025 1.0 null primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07624 HCC1588 CCLE Cell Line Gene Expression Profiles 1.0 1.92393 FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.25878 reticular formation of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16625 SMAD2/3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MRPL42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04044 cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19954 RAD21_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_18608_KO_Bend2_SRP348014 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.94752 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.042795 Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8082 medial part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20636 A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_2day-MOI-10^4_None_GSE43301 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.56596 Bone marrow TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.136 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cytosporone B DeepCoverMOA Drug Mechanisms of Action -1.0 -0.37 Neurodegeneration with brain iron accumulation 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.395 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27702 GSE233647_2_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32854 GSE88819_5_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null no-10 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.78841 GSE217405_3_v_2_osimertinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null DAOY CCLE Cell Line Gene CNV Profiles 1.0 1.45286 microorganisms GeneRIF Biological Term Annotations 1.0 null superficial stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57767 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.272655 Symplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.74 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7415-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE57875_1_v_0_hnrnpl_mouse RummaGEO Gene Perturbation Signatures 1.0 null Childhood Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER ChEA Transcription Factor Targets 2022 1.0 null KLF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.4873 r2 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70428 OCIAML2 CCLE Cell Line Gene Expression Profiles 1.0 1.50282 endoplasmic reticulum part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.37013 TCF3 ChEA Transcription Factor Targets 1.0 null XE-69-AT35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273337 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8872_THAP11_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.728954 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.990683 Perturb_1885_KO_Mettl14_SRP269254 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.41025 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03795 atherogenesis GeneRIF Biological Term Annotations 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.955504 Lek TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.516 NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.2069 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE142210_9_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223114 wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -1.10363 TE14 CCLE Cell Line Gene CNV Profiles 1.0 1.54297 intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13223 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-7636-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adenoma, Liver Cell CTD Gene-Disease Associations 1.0 1.22632 RELA_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Focal dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.197 intermediate stratum of r6Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16801 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Leukemia, Acute Megakaryocytic_Megakaryocyte_GSE2433 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.58312 HCC1500 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.06825 PMC7941712-40478_2021_1135_MOESM12_ESM.xlsx-Table_S4D_DEG_ST-EPN-RELA-Unnamed_6_RELA Rummagene Transcription Factor Associations 2026 1.0 null olfactory part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.872581 extrinsic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.355235 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null extracellular region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular component organization GO Biological Process Annotations 2015 1.0 null central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.864963 16081686-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-7658-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRKACA_knockout_266_GSE20984 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -3.01671 musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044223 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE93309_5_v_0_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null r11 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.04064 Fetal Death CTD Gene-Disease Associations 1.0 1.0608 BB-62-SZ35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.298789 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5J7-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4QQ-01A-41R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.623956 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.995469 GSE153836_14_v_5_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346399 GB-73-QS80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283792 IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.990799 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null stratum oriens of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.932652 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.057949 GSE81193_3_v_2_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE80537_0_v_2_adhfe1_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.869961 GSE183251_4_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null SPI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.541262 CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33401 KNS42 CCLE Cell Line Gene CNV Profiles -1.0 -1.75598 CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27967 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.094 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.953007 prostate BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.09548 PPP1R3E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84351 antimicrobial humoral response GO Biological Process Annotations 2025 1.0 null pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05524 CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Tafluprost DeepCoverMOA Drug Mechanisms of Action -1.0 -0.34 SPI1 ENCODE Transcription Factor Targets 1.0 null GSE140607_0_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE152432_1_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Atherosclerosis DisGeNET Gene-Disease Associations 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null U266B1 CCLE Cell Line Gene CNV Profiles 1.0 1.3845 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GW4064 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.64 H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A4IJ-01A-31R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Leydig cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null H3K4me1_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FF-86-NH56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252093 KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214997 Subiculum, dorsal part, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33991 CREB1 ENCODE Transcription Factor Targets 1.0 null CTCF-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GSE131649_2_v_1_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AHSA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51826 Acute Myeloid Leukemia_LAML_TCGA-AB-2835-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HD-99-BT62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.386782 GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.84933 testis_7b HPA Tissue Sample Gene Expression Profiles 1.0 1.2021 CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78N-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE138672_4_v_3_rabgef1_mouse RummaGEO Gene Perturbation Signatures 1.0 null b-lymphocyte cell line TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054246 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.378841 OSC-20 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.85157 Weight Loss CTD Gene-Disease Associations 1.0 1.44954 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21908 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I1-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPARD-21283829-MYOFIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.883207 intracellular organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.56712 HT144SKINFV2 DepMap CRISPR Gene Dependency 1.0 2.02935 hsa-miR-3074-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47249 JHU-011 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.18308 GSE163240_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.35328 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14217_KO_Mecp2_SRP061339 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.59678 GSE184884_4_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-2L-AAQL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6870-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157594_6_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE148200_3_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null FOXM1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pre-Renal Acute Kidney Injury DisGeNET Gene-Disease Associations 1.0 null RH18 CCLE Cell Line Gene CNV Profiles -1.0 -1.59731 hsa-miR-4292 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE217405_3_v_2_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.948508 H3K36me3_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20209 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UR-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TCF3-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null regulation of gene expression GO Biological Process Annotations 2025 1.0 null SKMEL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.58685 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null LIN7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00078 H3K27me3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0422 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null GSE120248,GSE120252_1_v_0_macf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null CD-26-MB82_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.399939 posteroventral (inferior) parietal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38234 TARBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04592 Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.933104 PMC9846571-Table_1.xls-1-NFE2L2_NFE2L2 Rummagene Transcription Factor Associations 2026 1.0 null lymphocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 10623_ZNF774_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 2.4646 H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 42MGBA CCLE Cell Line Gene Expression Profiles -1.0 -1.63523 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38103 CTCF_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE118617,GSE118619_2_v_3_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03256 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32396 HNT-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.48873 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null marrow cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null VMRCRCW_KIDNEY CCLE Cell Line Proteomics 1.0 3.1405 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06694 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.885943 Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETS1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17059 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null related GeneRIF Biological Term Annotations 1.0 null endoplasmic reticulum lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skeletal system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.136 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27733 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BY-01A-31R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BFTC909 CCLE Cell Line Gene Expression Profiles -1.0 -1.59078 MTDH_DEPLETION_GDS3179_98_human_LM2 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01932 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP2_02_42 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.5869 EP300_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLF4-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.992564 Prostate adenocarcinoma_PRAD_TCGA-KK-A7B3-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KAT2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adenocarcinoma of lung_Lung Tissue_GSE1037 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.85775 Anterior cingulate area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2031 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JARID1A-20064375-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null neuropeptide-S nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35637 Prepupa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.539 SARS-CoV MA15_Day4-TNFRsf1b KO_None_GSE40824 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.14346 Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null KMS-12-BM COSMIC Cell Line Gene Mutation Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HT-01A-12R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE88819_5_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H4K20me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38417 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKRC31 CCLE Cell Line Gene CNV Profiles -1.0 -1.55871 endoplasmic reticulum lumen GO Cellular Component Annotations 2025 1.0 null REST_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Field CA2, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38511 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22518 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RNH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35282 HCC1395 DepMap CRISPR Gene Dependency 1.0 2.07083 molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25109 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.57105 GSE76425_0_v_10_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Rennet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.722 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC4-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE146982_7_v_5_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3 ENCODE Transcription Factor Targets 1.0 null Nucleus of the optic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19348 Lung squamous cell carcinoma_LUSC_TCGA-39-5011-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158853_0_v_1_hmgcs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null morphine_mus musculus_gpl6246_gse17731 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null GSE127790_13_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055279 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.405 NCIH661 CCLE Cell Line Gene CNV Profiles 1.0 1.41091 posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09179 Brain Lower Grade Glioma_LGG_TCGA-DH-5142-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.59505 COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.837342 SARS-CoV MA15_Day7-PFU-10^5_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.55835 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null phagocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null medial (main) part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21822 H3K9ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-175-VII Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.49318 COLO 800 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.911972 5732_NOL10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.772225 CDK8_knockdown_130_GSE30816 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.65338 Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KISS1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12264 Anastrozole DeepCoverMOA Drug Mechanisms of Action -1.0 -0.43 RORC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0662 SW1116 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.00749 acids GeneRIF Biological Term Annotations 1.0 null granule cell layer of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52631 H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE173578_1_v_0_atf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00231 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE209598_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null granular layer of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.989346 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.48202 all GWASdb SNP-Phenotype Associations 1.0 0.028038 LXR-22292898-THP-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null arteriosclerotic cardiovascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.385565 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 578T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.53309 Ebolavirus(EBOV)_2day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.16685 E2F1-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FOXA1_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OC-10-FB51_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210695 SNU878 CCLE Cell Line Gene Expression Profiles -1.0 -1.56499 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Dowregulated-Gene_name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133683_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE142210_2_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null BF-97-LS55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245853 Stiripentol DeepCoverMOA Drug Mechanisms of Action -1.0 -0.25 TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100314_HIP_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.22426 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.88627 organic cyclic compound binding GO Molecular Function Annotations 2015 1.0 null HE-84-SC79_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.22153 FOXA2 ENCODE Transcription Factor Targets 1.0 null CD-47-YL43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.299139 ZFX ChEA Transcription Factor Targets 1.0 null hematopoietic cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.891639 ventrolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30479 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEN CCLE Cell Line Gene CNV Profiles -1.0 -1.36519 ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.915873 HCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00937 CCNQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03226 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29C-06A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Essential tremor DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.31 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03674 small molecule binding GO Molecular Function Annotations 2015 1.0 null H3K36me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.6462 STAT1 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null positive GeneRIF Biological Term Annotations 1.0 null vascular smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.652994 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TPBGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.156 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.81567 primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.26822 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.53329 9680_UTP14A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.930676 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.976477 GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null promonocytic leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.266757 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A7-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB33_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10544 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00734 CHEMBL2397099 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.58 PPARD-21283829-MYOFIBROBLAST-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.76384 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A64Z-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133516_5_v_6_kat7_human RummaGEO Gene Perturbation Signatures 1.0 null striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.825566 NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.22366 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01823 GSE95077_5_v_2_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null ROBO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48444 ITK_defectivemutant_125_GSE28200 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.43395 superficial stratum of DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42367 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.675407 PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.54558 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null orbital frontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.85293 FLI1-21867929-CD8-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD4_knockdown_223_GSE50865 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.88241 CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1915 CCLE Cell Line Gene Expression Profiles -1.0 -1.46004 GSE103068_5_v_3_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null RCC4 CCLE Cell Line Gene Expression Profiles -1.0 -2.20656 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.463752 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null monocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FA-80-DR66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.513885 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null effects GeneRIF Biological Term Annotations 1.0 null ABHD13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31159 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null placenta TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20604 SKCO1_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 6.17816 CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.5475 ZNF343 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.7093 ATF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4682 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 L-1236 COSMIC Cell Line Gene Mutation Profiles 1.0 null STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null r7 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14136 GSE208254_4_v_2_irf8_mouse RummaGEO Gene Perturbation Signatures 1.0 null r5 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44814 mononuclear cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066492 NANOG ENCODE Transcription Factor Targets 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4C6-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060336 BV173 CCLE Cell Line Gene CNV Profiles -1.0 -1.83581 nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Duckembryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.611 SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186810,GSE186813_2_v_1_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE181003_3_v_2_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null head of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04592 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.71774 HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribonucleotide binding GO Molecular Function Annotations 2015 1.0 null GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.200117 Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GFI1B-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ethynyl Estradiol DeepCoverMOA Drug Mechanisms of Action -1.0 -0.32 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01132 TC-95-IR96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.312937 GSE138019_3_v_2_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE97278,GSE97280_2_v_1_nsd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null polycystic GeneRIF Biological Term Annotations 1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Hepatitis, Autoimmune_Hepatic Tissue_GSE867 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.39902 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.42593 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dysfunction GeneRIF Biological Term Annotations 1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.95535 7424_RPAP3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.587674 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.242363 RAD21_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE190186,GSE190188_8_v_5_apoe_mouse RummaGEO Gene Perturbation Signatures 1.0 null CC-61-HH09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.290575 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.899124 H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE236502_2_v_3_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null TENT4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24462 Prostate adenocarcinoma_PRAD_TCGA-HC-A6HY-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3CC-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.0111 whilst GeneRIF Biological Term Annotations 1.0 null p2 portion of the substantia nigra pars reticulata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01925 REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06256 PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-233-SP110_SP110 Rummagene Transcription Factor Associations 2026 1.0 null IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47513 PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null nucleus of the diagonal band, left, vertical division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19966 SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.893134 diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.251836 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17023 GSE127970_1_v_0_ebf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37896 GSE88819_5_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_9159_KD_DHX9_SRP346212 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 18.585 Hoof TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.557 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.913226 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.490689 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.53077 SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOUAI DepMap CRISPR Gene Dependency 1.0 2.0132 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Taenia tecta, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00034 OACP4C COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 inferior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.885111 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null regulation of cAMP-mediated signaling GO Biological Process Annotations 2025 1.0 null r7 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73274 GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null markers GeneRIF Biological Term Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-6D-AA2E-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.815429 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null type 2 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.509681 GSE113385_0_v_1_six1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null AKT1_knockout_211_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.48933 protein homooligomerization GO Biological Process Annotations 2015 1.0 null VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854726 organelle LOCATE Predicted Protein Localization Annotations 1.0 null NCOR1-26117541-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE58724_3_v_0_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48641 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06238 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null KAT2B ENCODE Transcription Factor Targets 1.0 null PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240186 GSE159206_1_v_3_drd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null mononuclear phagocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GB-73-QS80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.430367 GSE189683_1_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null macrophage foam cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.46682 arteriosclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.370737 r6 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17059 HS571T CCLE Cell Line Gene Expression Profiles -1.0 -2.05558 PMC6977700-aging-12-102667-s004..xlsx-Stage2-The_identified_459_dysregulated_LmiRM-CTs_in_stage_2_of_MI_4-6_days_after_MI_using_our_method_MITF Rummagene Transcription Factor Associations 2026 1.0 null OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.99676 GSE195786_0_v_1_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16855 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null 699_ATR_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.55655 mitogenesis GeneRIF Biological Term Annotations 1.0 null hsa-miR-27a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 intracellular organelle lumen GO Cellular Component Annotations 2023 1.0 null H3K79me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-L3-A524-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF7L ChEA Transcription Factor Targets 1.0 null MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09884 ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SREBF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pentadecanoyl EA DeepCoverMOA Drug Mechanisms of Action -1.0 -0.36 AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.403023 UBTF ENCODE Transcription Factor Targets 1.0 null superficial stratum of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70428 Perturb_3998_KD_RIOK3_SRP116196 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null atherosclerosis GeneRIF Biological Term Annotations 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE89729_0_v_1_ppard_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22375 MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44617 phagocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.264696 C1orf116 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10216 Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Polycystic Ovary Syndrome DisGeNET Gene-Disease Associations 1.0 null HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.925356 glucose metabolism disease GWASdb SNP-Disease Associations 1.0 0.231002 Cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PRIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52077 AB-70-GR31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218057 RAD21_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null antiatherosclerotic GeneRIF Biological Term Annotations 1.0 null inner CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.848064 PAX5 ENCODE Transcription Factor Targets 1.0 null ChIP_REST_21632747 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22412 OV56 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21819 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.98375 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE144838_2_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE60691_2_v_3_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Brain - Cerebellum GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.862154 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null positive regulation of macromolecule biosynthetic process GO Biological Process Annotations 2025 1.0 null THAP11 ChEA Transcription Factor Targets 1.0 null preeclampsia GeneRIF Biological Term Annotations 1.0 null RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27843 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7592 Left_Ventricle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.910881 Apraxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Phagocyte TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.926299 496100324_FWM_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.03423 ZNF285 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40513 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGBC52TKB DepMap CRISPR Gene Dependency 1.0 2.13806 Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36447 SAP30 ENCODE Transcription Factor Targets 1.0 null red nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09047 H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Hereditary spastic paraplegia 26 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.164 inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4476 Cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24976 abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.031 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 peptides GeneRIF Biological Term Annotations 1.0 null GSE161064,GSE161065_0_v_1_kdm5b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Woodhouse-Sakati syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.063 MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03261 retina BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.00636 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 900 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.962444 GSE44157,GSE44163_3_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_7day-MOI-10^4_None_GSE37572 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 4.26175 Western equine encephalitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.336 H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Endoplasmic reticulum exit site COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.851 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SA-01A-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02618 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3661 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 P-loop containing nucleoside triphosphate hydrolase InterPro Predicted Protein Domain Annotations 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.83211 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.17752 GSE157594_6_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null Balanoposthitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.093 GSE239541_11_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null amino GeneRIF Biological Term Annotations 1.0 null GSE139966_4_v_3_figla_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF385B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57931 BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.401421 lymphoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059436 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Darifenacin DeepCoverMOA Drug Mechanisms of Action -1.0 -0.39 CTCF_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.963117 A549 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.836966 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 RAD21_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0919 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32761 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCI-AML5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.15478 GSE211286_4_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null FC-68-LJ11_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.506543 Endoplasmic reticulum COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ChIP_THAP11_20581084 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.63284 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Heart Failure DisGeNET Gene-Disease Associations 1.0 null NCIH1581 CCLE Cell Line Gene CNV Profiles -1.0 -1.52275 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null exerts GeneRIF Biological Term Annotations 1.0 null nucleotide binding GO Molecular Function Annotations 2015 1.0 null POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle lumen GO Cellular Component Annotations 2025 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null protein metabolic process GO Biological Process Annotations 2015 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IFIT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09853 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.24859 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54G-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169571_0_v_2_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null Masseter TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.055 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.853087 estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null neointima TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.781894 Adductor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.616 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null locus ceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.851493 r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03753 CTCF_astrocyte of the cerebellum_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180789_1_v_0_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.29422 superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.19682 Calcium HMDB Metabolites of Enzymes 1.0 null r7 part of the dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43199 RUNX1 ChEA Transcription Factor Targets 1.0 null SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186810,GSE186813_2_v_1_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null Flocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37167 CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null E2A MotifMap Predicted Transcription Factor Targets 1.0 null SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGW DepMap CRISPR Gene Dependency 1.0 2.052 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null 20174566-TableS1 GeneSigDB Published Gene Signatures 1.0 null retina BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.21566 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UPF3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15803 TEDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4344 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47219 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null p1 part of the substantia nigra reticulata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01634 atp binding GO Molecular Function Annotations 2015 1.0 null Sarcoma_SARC_TCGA-DX-A3M1-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Resmetirom DeepCoverMOA Drug Mechanisms of Action -1.0 -0.3 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.393034 MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pontine raphe nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.28205 NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.35574 RAD21_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 4951_MED28_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.56811 CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.54316 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MAPK14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16329 COLO818 CCLE Cell Line Gene Expression Profiles -1.0 -2.54118 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.845757 designated GeneRIF Biological Term Annotations 1.0 null GSE238116_1_v_2_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.423 lymphoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057354 GSE199660_1_v_0_secretin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null positive regulation of cation transmembrane transport GO Biological Process Annotations 2025 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null GSE163862_2_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null macrophage TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.238406 Kidney Chromophobe_KICH_TCGA-KL-8324-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Central Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Six3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.5624 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.03567 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27978 E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null DCTN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02396 TE1 CCLE Cell Line Gene Expression Profiles 1.0 1.6441 hypertensive GeneRIF Biological Term Annotations 1.0 null GSE158834_2_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null KC-48-OO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.25976 SUPT6H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11776 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YA-78-MS95_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.525334 NAP1L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53054 COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.899356 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Secondary motor area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02618 RAD21_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.240148 HS 255.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25075 GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.820975 Sickle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.258 BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.688142 carotid GeneRIF Biological Term Annotations 1.0 null chr9_127732532_T_C_b38 GTEx eQTL 2025 1.0 1.23628 ELK4 ENCODE Transcription Factor Targets 1.0 null SP in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.989709 subthalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.937872 BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.315963 Dentate gyrus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3713 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC70_BREAST CCLE Cell Line Proteomics 1.0 2.81433 H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null hsa-miR-3907 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.88983 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CFPAC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.55235 GSE77108_0_v_2_saha_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Penis_Foreskin_Keratinocyte_Primary_Cells_skin02 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.13277 SP1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176008_0_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null 3291_GATA1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.513918 TEAD4 ENCODE Transcription Factor Targets 1.0 null GSE158969_1_v_2_trastuzumab_human RummaGEO Drug Perturbation Signatures -1.0 null Dorsal peduncular area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09822 ESR1 ENCODE Transcription Factor Targets 1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_targets-genes_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.53308 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1207-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 isthmic roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28711 A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.40388 KDM5A ChEA Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF7L-23326641-C3H10T1-2-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null reported GeneRIF Biological Term Annotations 1.0 null 496100400_PCx_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13133 PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null SK-OV-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null Anterior cingulate area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72189 H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null infection GAD High Level Gene-Disease Associations 1.0 0.293278 10663_ZNF830_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.661296 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hydroxylase GeneRIF Biological Term Annotations 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tcf12_20154672_cd4pos_cd8pos_thymocytes_thymus_lof_mouse_gpl6246_gse19923 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.020538 MM160113 DepMap CRISPR Gene Dependency 1.0 2.15963 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SW1710 COSMIC Cell Line Gene Mutation Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176008_7_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.72299 MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.883824 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_1day-MOI-10^4_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.70248 Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.29673 r5 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71375 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.873054 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2019 3447_GNL3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.896413 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tuberomammillary nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72514 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.21146 atherosclerotic plaque TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.880358 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE168918_1_v_0_tmprss4_human RummaGEO Gene Perturbation Signatures -1.0 null TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.566206 basal nucleus of meynert, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.904991 Nucleus of the lateral lemniscus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17059 CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.615233 VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.995987 KM12 COSMIC Cell Line Gene Mutation Profiles 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02646 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67A-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATF3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13384 r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22667 H3K4me1_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POU5F1 ChEA Transcription Factor Targets 1.0 null VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07551 7690_SCD_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.824311 CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.955504 ATF2 ENCODE Transcription Factor Targets 1.0 null POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null receptor ligand activity GO Molecular Function Annotations 2025 1.0 null FC-64-QJ96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217717 Cyanuric chloride DeepCoverMOA Drug Mechanisms of Action -1.0 -0.52 HCC1954 CCLE Cell Line Gene CNV Profiles 1.0 1.93529 endoplasmic reticulum lumen GO Cellular Component Annotations 2023 1.0 null GSE232631_5_v_3_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null KIF18A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15214 H3K36me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null Learning Disorders CTD Gene-Disease Associations 1.0 1.16203 subbrachial nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21211 MZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45111 BMS309403 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.26 KLF4 ChEA Transcription Factor Targets 1.0 null H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BB-77-QQ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.2289 CTCF_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null H3K36me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE222047_0_v_1_imidazole_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25542 inner SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.996383 PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.865586 Cervical dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.02 GLIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.2236 GSE162739_8_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null blood vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.117548 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.7294 relationship GeneRIF Biological Term Annotations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pars distalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.571 KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 76.769 FOSL2 ENCODE Transcription Factor Targets 1.0 null GSE154219_0_v_2_cholestyramine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Leukocyte TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EXOC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06469 L755507 DeepCoverMOA Drug Mechanisms of Action 1.0 0.68 SNU423 DepMap CRISPR Gene Dependency 1.0 2.24287 ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.7531 H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE149903_6_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8405-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE119978,GSE180930_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC12178937-mmc6.xlsx-L_MAFF_KDvsL_C_deg_all-gene_name_MAFF Rummagene Transcription Factor Associations 2026 1.0 null GSE242083,GSE242098_3_v_4_med1_human RummaGEO Gene Perturbation Signatures 1.0 null III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.864116 GSE198982,GSE198986_1_v_2_daunorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.828266 EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245793 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7671_SBNO2_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.575044 HSD17B4_KO_GDS3468_503_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE193402_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28424 lateral IC periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0275 8872_THAP11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.921454 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AQR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37238 CCLFPEDS0001T DepMap CRISPR Gene Dependency 1.0 2.10041 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36184 IMPACT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91616 ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.57685 Kidney Chromophobe_KICH_TCGA-KL-8328-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCOF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05393 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05026 CTCF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 260.758 trigeminal BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.01645 primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.970844 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE43041,GSE43044_0_v_1_ldb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04046 Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01932 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28336 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-66-NV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243591 H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF4-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3 ENCODE Transcription Factor Targets 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.984611 PROX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15497 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.307167 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5UA-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054043 NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.7271 orbital frontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.932415 GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.9102 7275_RGS14_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.575108 hsa-miR-631 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE157555,GSE157556_5_v_6_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MET_knockdown_254_GSE38343 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.17201 metabolic process GO Biological Process Annotations 2015 1.0 null POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35345 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of PCPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46617 SPI1 ChEA Transcription Factor Targets 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE225218_8_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null membrane-enclosed lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8479-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prelimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38356 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.844307 GSE135244_0_v_1_trdmt1_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM190 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59153 BICR22 CCLE Cell Line Gene CNV Profiles 1.0 1.50251 testis_7a HPA Tissue Sample Gene Expression Profiles 1.0 0.894788 PMC10245467-mmc3.pdf-266-TBX2_TBX2 Rummagene Transcription Factor Associations 2026 1.0 null l90 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.168 posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.979631 intermediate stratum of r5Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15334 Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8S1-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-WN-A9G9-01A-12R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Tuberomammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31472 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RKN Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.00209 F36P CCLE Cell Line Gene Expression Profiles 1.0 1.54254 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.879043 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.92244 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null DNA polymerase III, clamp loader complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.196 pineal_night BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.866556 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null substantia nigra reticulata, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12877 CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3474 superficial stratum of PHyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1749 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATF3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49C-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF3-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null skeletalmuscle BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.827316 CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H661 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.04162 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ligand GeneRIF Biological Term Annotations 1.0 null r10 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29815 Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.20816 CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05056 EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.86018 HC-92-HE59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.424123 CTCF_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_5_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE140607_3_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS274T CCLE Cell Line Gene Expression Profiles -1.0 -1.53204 PHF8 ENCODE Transcription Factor Targets 1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34125 LS1034 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.05314 APBB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29088 hsa-miR-27b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE255432_6_v_2_imeglimin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Feather calamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.349 GSE203308_4_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BCL3 ENCODE Transcription Factor Targets 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null type ii diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.435375 acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.127792 GSE149621_3_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.13987 Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.86625 intracellular part GO Cellular Component Annotations 2015 1.0 null lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05181 Primary somatosensory area, trunk, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09437 r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.04956 AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.21353 HMGN3 ENCODE Transcription Factor Targets 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.896017 RFX5 ENCODE Transcription Factor Targets 1.0 null Suprageniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03673 REST-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.906751 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of r4Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07784 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CAL 27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0002 GSE171572_1_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.40474 496100381_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.2635 CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21908 1197_CARS_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.67681 endopiriform nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09845 dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.889954 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.15864 KA-29-AB08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249871 Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null substantia nigra reticulata, isthmic part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14195 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.97336 posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.345 TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 141.056 TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.916341 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pallidohypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.36924 DD-74-PJ26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229677 Prelimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07137 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.870384 KA-75-LP02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251093 decrease GeneRIF Biological Term Annotations 1.0 null GSE201042_2_v_3_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE171837_3_v_1_bortezomib_mouse RummaGEO Drug Perturbation Signatures 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01823 PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.451706 SW1573 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.72826 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A764-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Retrochiasmatic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16004 muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.056475 CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_epithelial cell of esophagus_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.11009 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTMR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05185 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0929 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.12283 GMNN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.13952 Peripheral_Blood_Mononuclear_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.62527 H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE192689_0_v_2_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.79629 SP4 ENCODE Transcription Factor Targets 1.0 null lesions GeneRIF Biological Term Annotations 1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NN-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40699 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42E-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SREBF1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8072-01A-31R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.941868 Dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.327 superficial stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29845 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE210580_0_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SRXN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21136 H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29943 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null organism form TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null superficial stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10655 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null carbohydrate derivative binding GO Molecular Function Annotations 2015 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22477 MHH-PREB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.875533 Hereditary lymphedema II DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.268 CSTF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69405 CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null identification GeneRIF Biological Term Annotations 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.65271 organelle part GO Cellular Component Annotations 2015 1.0 null SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48739 outer CP in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20013 AD-16-HL96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.337514 19334046-TableS3a GeneSigDB Published Gene Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26323 H3K4me1_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE159473_0_v_1_eif5a2_human RummaGEO Gene Perturbation Signatures -1.0 null Tumor Progression DisGeNET Gene-Phenotype Associations 1.0 null G64527OM GlyGen Glycosylated Proteins 1.0 null Superior olivary complex, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96126 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE120413,GSE120447_3_v_2_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null primary auditory cortex (core)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.9626 intermediate part of the arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29144 KMS28BM CCLE Cell Line Gene Expression Profiles 1.0 2.80695 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Monocyte TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26045 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.00926 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A183-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31318 H3K27me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RRP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.59665 REST_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE134191_3_v_5_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null DF-00-BU08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220023 HS255T CCLE Cell Line Gene Expression Profiles -1.0 -2.62891 mammarygland.lact. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.62155 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15763 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885333 r5 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13867 posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.892806 Essential Hypertension DisGeNET Gene-Disease Associations 1.0 null magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.89244 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885333 Lung adenocarcinoma_LUAD_TCGA-38-4626-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-483 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.42842 CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA ChEA Transcription Factor Targets 2022 1.0 null GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5A ENCODE Transcription Factor Targets 1.0 null GSE71385_1_v_0_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.43376 purine nucleotide binding GO Molecular Function Annotations 2015 1.0 null TTF2 ChEA Transcription Factor Targets 1.0 null GSE103122_0_v_1_puromycin_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.13631 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02741 GSE196540,GSE196542_2_v_3_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.333687 COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02488 Sarcoglycan complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.669 hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01178 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A656-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RM-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 4220_ITFG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.533185 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00805 Cochlear nucleus, subpedunclular granular region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19382 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null veins GeneRIF Biological Term Annotations 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.82033 periventricular stratum of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34696 MV411 CCLE Cell Line Gene Expression Profiles 1.0 1.64056 oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.903921 PSMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70322 H4K20me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.98202 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Neoplasm Metastasis CTD Gene-Disease Associations 1.0 1.08513 Right_Atrium Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.28433 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of m1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29637 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1-33199912-293T-HUMAN-KIDNEYEMBRYO ChEA Transcription Factor Targets 2022 1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.950906 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.69794 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE140607_5_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null protein complex assembly GO Biological Process Annotations 2015 1.0 null FOSL2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Taenia tecta, dorsal part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12296 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.63 serum GeneRIF Biological Term Annotations 1.0 null primary metabolic process GO Biological Process Annotations 2015 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.274744 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.858656 Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.39135 PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null ZFX-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null characterization GeneRIF Biological Term Annotations 1.0 null H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.960627 CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00214 GSE207787_3_v_2_pdha1_human RummaGEO Gene Perturbation Signatures 1.0 null VMRCRCZ CCLE Cell Line Gene CNV Profiles -1.0 -1.63215 MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4955670__F5 PFOCR Pathway Figure Associations 2023 1.0 null VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59554 RAD21_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31825 CCDC50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51726 RAD21_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8580-01A-31R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06229 POU2F2 ENCODE Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q8-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-3B-A9HO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226584,GSE226589_2_v_0_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null STAT1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE112761,GSE112767_4_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.887756 AAA+ ATPase domain InterPro Predicted Protein Domain Annotations 1.0 null Anterior cingulate area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03996 regulators GeneRIF Biological Term Annotations 1.0 null GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4251 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.94665 H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLF4-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Cells - EBV-transformed lymphocytes GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.12243 SIRT3_KO_GDS4817_416_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM109 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36795 GSE183251_1_v_3_cyp2c70_mouse RummaGEO Gene Perturbation Signatures 1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.16641 PRPF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29125 CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE241701_2_v_3_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null Multifocal dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.373 VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.00761 NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.538962 G70101JE GlyGen Glycosylated Proteins 1.0 null PMC12178937-mmc6.xlsx-D_MAFF_KDvsD_C_deg_all-gene_id_MAFF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR3A_01_139 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.5904 r3 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53709 ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228289 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE68155_1_v_0_gpr3_mouse RummaGEO Gene Perturbation Signatures -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.3522 RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.56804 H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SREBP1-19666523-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.0616 Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.078394 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUP155 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3471 intermediate stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00805 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.272061 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19309 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17661 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYOD1_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.09354 GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE196540,GSE196542_4_v_5_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH1876 CCLE Cell Line Gene CNV Profiles 1.0 2.00994 PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13 Rummagene Transcription Factor Associations 2026 1.0 null GATD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11993 DLD-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null there GeneRIF Biological Term Annotations 1.0 null lateral terminal nucleus of the accessory optic tract, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36942 FMO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72818 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null wm115 HPA Cell Line Gene Expression Profiles -1.0 -0.887516 ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.862305 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SR786 CCLE Cell Line Gene CNV Profiles -1.0 -1.84271 GSE152937_6_v_5_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF682 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.173 P68-20966046-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Abnormalities, Multiple CTD Gene-Disease Associations 1.0 1.04868 ZBTB33 ENCODE Transcription Factor Targets 1.0 null regulator GeneRIF Biological Term Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5946-02A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834505 Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.846155 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE119978,GSE180930_3_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.876771 urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053914 nucleus subcoeruleus, r1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60555 AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09567 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AASS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4093 LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null GFI1B-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.00708 H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null positive regulation of intracellular signal transduction GO Biological Process Annotations 2025 1.0 null KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE124375_13_v_0_chd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.28143 657_ATP5F1E_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.523978 PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231648_0_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H292 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.3397 paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25763 ZNF384 ENCODE Transcription Factor Targets 1.0 null CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SIX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_SK-N-SH_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null released GeneRIF Biological Term Annotations 1.0 null THAP11-20581084-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Retrosplenial area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6244 vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06707 corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26624 Granular lamina of the cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06165 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03648 Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.94857 mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.2015 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.71683 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_4day-MOI-10^4_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.90793 Nuclear membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.395 NFYB ENCODE Transcription Factor Targets 1.0 null NELFE ENCODE Transcription Factor Targets 1.0 null GSE144443_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE88819_11_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7312-01B-21R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null REST_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null atherosclerotic GeneRIF Biological Term Annotations 1.0 null u-937 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.266757 biological_process GO Biological Process Annotations 2015 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FTC-133 COSMIC Cell Line Gene Mutation Profiles 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.61222 VDR ChEA Transcription Factor Targets 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231648_4_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null YY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01892 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vascular Inflammations DisGeNET Gene-Phenotype Associations 1.0 null H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.944544 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null NRF1 ENCODE Transcription Factor Targets 1.0 null H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHH-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.70084 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.963604 purine ribonucleoside triphosphate binding GO Molecular Function Annotations 2015 1.0 null IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.75525 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 9420_TUBB_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.542318 liver HPA Tissue Gene Expression Profiles -1.0 -0.987365 muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.057432 MDA-MB-436 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.27278 inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04347 H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.477067 G361 CCLE Cell Line Gene CNV Profiles 1.0 1.33772 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.959732 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01932 leukocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062325 SRF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial dorsofrontal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45977 YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.898213 dentate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25199 CTCF ENCODE Transcription Factor Targets 1.0 null CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CW2 CCLE Cell Line Gene Expression Profiles 1.0 1.52258 other source TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07753 GSE143994_2_v_1_ythdf1_human RummaGEO Gene Perturbation Signatures 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.515893 NCIH69 CCLE Cell Line Gene Expression Profiles 1.0 2.08155 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null torsinamediated GeneRIF Biological Term Annotations 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.035 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6SW-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.16203 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE217115_3_v_5_alectinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-8153-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63417 layer 1 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43458 chaperone-mediated protein folding GO Biological Process Annotations 2015 1.0 null FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE127790_4_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null RPL29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79614 Dentate gyrus, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31335 PPARD ChEA Transcription Factor Targets 1.0 null NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14891 Multiple Sclerosis DisGeNET Gene-Disease Associations 1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Spasmodic dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.809 496100365_HIP_probable Alzheimer's disease_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.53249 muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065354 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K8-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100346_FWM_no dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.12137 SW620 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.9029 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LMO2-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CML-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null mice GeneRIF Biological Term Annotations 1.0 null E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.36138 True leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.631 atherosclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.387423 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Pelger-Huet anomaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.161 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57493 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null myeloid progenitor cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KYO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.75982 NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.884278 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endoplasmic reticulum part GO Cellular Component Annotations 2015 1.0 null Perturb_3467_KO_Tie2_SRP325056 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.6647 GSE160765_2_v_1_twist1_human RummaGEO Gene Perturbation Signatures -1.0 null AOB, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26991 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Hs-939-T Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.80765 B-lymphocyte cell line TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 core part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04255 Infralimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19757 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12153 posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.825566 Carcinoma, Ovarian Epithelial DisGeNET Gene-Disease Associations 1.0 null GSE152937_12_v_7_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UF-27-HS98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.352826 BMS 303141 DeepCoverMOA Drug Mechanisms of Action 1.0 0.39 spinalcordupper BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.10582 MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1626 ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null HCC3153 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.735084 IA-27-CK10_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.285327 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5551-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral interstitial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.74408 RUNX2-24655370-MC3T3E1-MOUSE-BONE ChEA Transcription Factor Targets 2022 1.0 null Roe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.48 superficial stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35038 nucleus of Barrington Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22512 DHX58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08973 SNU349 CCLE Cell Line Gene Expression Profiles -1.0 -1.92667 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22534 protein oligomerization GO Biological Process Annotations 2015 1.0 null CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_17652_KD_DNMT3A_SRP367237 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.88964 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63668 BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.403132 Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.10499 SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryo TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ELK1_01_162 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 9.75586 JHH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.31051 PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_11_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4529-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 ARID3A ENCODE Transcription Factor Targets 1.0 null Dentate gyrus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43299 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r1BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59062 H3K4me1_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE202284,GSE202289_1_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CFPAC1_PANCREAS CCLE Cell Line Proteomics 1.0 3.17725 sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.583721 KLF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 106.971 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PANC0213 CCLE Cell Line Gene CNV Profiles 1.0 1.35685 GSE111035,GSE111040_3_v_13_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.330268 PGM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01165 Nuclear envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.724 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.82872 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EO-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83T-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null positive regulation of calcium ion transmembrane transport GO Biological Process Annotations 2025 1.0 null dopaminergic GeneRIF Biological Term Annotations 1.0 null superficial stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36868 knockout GeneRIF Biological Term Annotations 1.0 null stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.91524 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RET_druginhibition_184_GSE49414 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.11201 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null Nuclear envelope lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.898 phenotype GeneRIF Biological Term Annotations 1.0 null RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cortical endoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.736 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.44175 Barrington's nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78379 KNS42 CCLE Cell Line Gene Expression Profiles -1.0 -2.88575 NFIC ENCODE Transcription Factor Targets 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.28289 dorsalrootganglion BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.3391 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_KLF4_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Field CA2, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21822 GSE130715_2_v_3_budesonide_human RummaGEO Drug Perturbation Signatures 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZEB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null BE-79-QU25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377191 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41182 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.82432 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.875843 Flocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38564 ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250807 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hematopoietic stem cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH2030 CCLE Cell Line Gene CNV Profiles -1.0 -1.62544 NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null THAP1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF ENCODE Transcription Factor Targets 1.0 null internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227791 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46334 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.013186 YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP66-MEL Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.11997 CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-58-8386-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ERG_ERG Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4167-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHL1DM DepMap CRISPR Gene Dependency 1.0 2.18712 Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3YL-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521 Rummagene Transcription Factor Associations 2026 1.0 null FA-65-UA27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.363392 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885333 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HA-E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA Rummagene Transcription Factor Associations 2026 1.0 null Placenta TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.876771 RUNX3 ENCODE Transcription Factor Targets 1.0 null NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null 888 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27873 G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10417 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mononuclear cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hsa-miR-326 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.889366 CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.951233 HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.60929 ZC3H11A_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null 16498405-TableS4 GeneSigDB Published Gene Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA5_KO_GSE47425_50_mouse_lung GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null heart muscle HPA Tissue Gene Expression Profiles -1.0 -1.11454 DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.315765 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5444-01A-02R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08127 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null RPS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0833 Disease Susceptibility HuGE Navigator Gene-Phenotype Associations 1.0 null EFO-27 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.46026 DF-95-CY55_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231634 regulation of calcium ion transmembrane transport GO Biological Process Annotations 2025 1.0 null CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCKIPSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0322 GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML ENCODE Transcription Factor Targets 1.0 null USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07765 U266B1 CCLE Cell Line Gene Expression Profiles 1.0 1.38898 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75549 ChIP_KLF4_19030024 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TEAD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3599 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null RAD21_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8506-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE212848_1_v_0_pum1_human RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241498 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE116299_6_v_1_folic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null lymphoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059896 IM-95 COSMIC Cell Line Gene Mutation Profiles 1.0 null outer SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.860897 10924_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.577912 VMRCRCZ CCLE Cell Line Gene Expression Profiles -1.0 -2.21006 GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE154940_1_v_0_nbdy_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null adenyl ribonucleotide binding GO Molecular Function Annotations 2015 1.0 null HUVEC Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.868128 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Arteriosclerosis DisGeNET Gene-Disease Associations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Taenia tecta, dorsal part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10997 FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU5F1-18700969-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null OAW28 CCLE Cell Line Gene Expression Profiles 1.0 1.55281 E2F6 ENCODE Transcription Factor Targets 1.0 null ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.3406 biosynthesized GeneRIF Biological Term Annotations 1.0 null Nucleus of the lateral lemniscus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1254 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4426 SUPV3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01229 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null NCIH292_LUNG CCLE Cell Line Proteomics 1.0 9.45963 hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20534 organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null subgranular zone of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26092 Lef1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.9445 Weight Gain CTD Gene-Disease Associations 1.0 1.17464 Lung squamous cell carcinoma_LUSC_TCGA-56-7730-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54264 MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.4796 GATA3-24758297-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07895 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02507 bonemarrow_6b HPA Tissue Sample Gene Expression Profiles 1.0 1.57798 PMC4823830-ncomms11171-s3.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NK-A5D1-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26082 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE70883,GSE71179_0_v_1_pbx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF460 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 111.904 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null IE-38-FB31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.267022 positive regulation of calcium ion transport GO Biological Process Annotations 2025 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease Progression HuGE Navigator Gene-Phenotype Associations 1.0 null G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885333 GSE173911,GSE173917_0_v_1_morc3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.29041 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01823 ZC3H11A ENCODE Transcription Factor Targets 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1834_KO_Ogt_SRP250299 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.6319 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.32852 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A69B-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09987 fetus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Organelle envelope lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.563 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 salusinalpha GeneRIF Biological Term Annotations 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer I of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.935267 MYC ENCODE Transcription Factor Targets 1.0 null CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null PRDM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05176 CHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.837957 ICC15 DepMap CRISPR Gene Dependency 1.0 2.12565 L363 CCLE Cell Line Gene Expression Profiles 1.0 1.745 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE184892_0_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null GSE180185_7_v_1_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.86528 Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_15122_KD_PRKAB1_SRP076036 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 15.6599 VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0508 CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null GSE178292_0_v_3_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.95349 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L8-01A-21R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25697 CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LS-513 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 3.12062 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24036 Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VMRCLCP CCLE Cell Line Gene CNV Profiles -1.0 -1.49006 H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null STK368746 DeepCoverMOA Drug Mechanisms of Action 1.0 0.37 antiatherogenic GeneRIF Biological Term Annotations 1.0 null organelle lumen GO Cellular Component Annotations 2015 1.0 null H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38012 hsa-miR-4732-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.219115 CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -4.09918 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.960627 Paraventricular nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.923 MRPL13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26721 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.3601 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.117 TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE93309_1_v_0_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXH1-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.930072 USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A8BN-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDGFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1071 Lung adenocarcinoma_LUAD_TCGA-62-8394-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202603_3_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null SK-MEL-24 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14475 496100336_TCx_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.00267 H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Dorsal peduncular area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46292 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null heterocyclic compound binding GO Molecular Function Annotations 2015 1.0 null hsa-miR-4509 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 hsa-miR-599 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE157555,GSE157556_4_v_7_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63417 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDX46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14252 PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-Fig7e-CTCF_in_promoter_CTCF Rummagene Transcription Factor Associations 2026 1.0 null mantle zone of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62799 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55267 GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BE-31-XV38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.2792 GSE211286_7_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null ANAPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20518 GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.26012 ZNF76 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.6689 adenyl nucleotide binding GO Molecular Function Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-MN-A4N5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleoside binding GO Molecular Function Annotations 2015 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B2-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vascular tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.803961 laterodorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43774 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.83886 women GeneRIF Biological Term Annotations 1.0 null SARS-BatSRBD_60Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.71259 PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-genes_with_VDR_peaks_with_and_without_D3_VDR Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14261 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69804 dorsolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03733 against GeneRIF Biological Term Annotations 1.0 null TP53-32428506-HUMAN-LIVER-HEPTOMA ChEA Transcription Factor Targets 2022 1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.884372 Quinidine DeepCoverMOA Drug Mechanisms of Action 1.0 0.68 ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19218430-TableS3 GeneSigDB Published Gene Signatures 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14341 Hypertrophy CTD Gene-Disease Associations 1.0 1.14713 VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.938832 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null accelerates GeneRIF Biological Term Annotations 1.0 null EFM-19 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.41779 Adenoma of small intestine_Intestinal Epithelium_GSE422 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.96496 lymphnode_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.10818 GA-88-CF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.306818 GSE122067_3_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RAD21_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hormone activity GO Molecular Function Annotations 2025 1.0 null EA-18-FP00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.394179 SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.438 3291_GATA1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.652119 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null coronary artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.256299 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR8_OVARY CCLE Cell Line Proteomics 1.0 2.66768 ZNF385C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07602 RMI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05997 mononuclear phagocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073786 Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.8245 Acute Myeloid Leukemia_LAML_TCGA-AB-2932-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.879386 VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE154577_7_v_12_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null SOX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50353 MONOMAC1 CCLE Cell Line Gene Expression Profiles 1.0 1.40119 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dystonia GeneRIF Biological Term Annotations 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.79465 AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.999788 PPIL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18101 INTS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66669 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.49974 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pleural cavity TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.559 Brain Lower Grade Glioma_LGG_TCGA-TM-A84T-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UA-39-TN76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.288149 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RFX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.811 CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DICER1_KO_GDS4504_583_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null lymphoid tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05234 SIX5 ENCODE Transcription Factor Targets 1.0 null AB-64-ZX70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245809 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.79164 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11401508-NIHMS2019525-supplement-2.xlsx-Sheet1-SP1_candidate_repressors_SP1 Rummagene Transcription Factor Associations 2026 1.0 null GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HC-01-FD24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23537 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.301495 Zebularine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.31 Fields of Forel Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15996 GSE216273,GSE216292_0_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE165548_2_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19563 H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null UPF3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43718 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11752 abnormality of carbohydrate metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.162059 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37314 extracellular region LOCATE Curated Protein Localization Annotations 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03941 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUN ENCODE Transcription Factor Targets 1.0 null CTCF_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.93686 essential hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.406798 E2F4 ENCODE Transcription Factor Targets 1.0 null H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PLEKHA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12145 blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061834 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21327 CTCF_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.26531 nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.272319 H3K27me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null purine ribonucleoside binding GO Molecular Function Annotations 2015 1.0 null Purkinje layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.622 SF268 COSMIC Cell Line Gene Mutation Profiles 1.0 null intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12274 ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05499 PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.891941 H3K9me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null XRN2-22483619-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null carbohydrate metabolism disease GWASdb SNP-Disease Associations 1.0 0.231002 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.90587 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.6739 CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.43236 Lung adenocarcinoma_LUAD_TCGA-71-6725-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18361 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null DF-84-RT50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.586549 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.83707 496100360_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0627 CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-61-OO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.48573 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.7284 496100589_PCx_dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10672 AF-99-HA02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249178 NUGC3 CCLE Cell Line Gene CNV Profiles 1.0 1.39602 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.55706 Lamin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.503 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12178937-mmc6.xlsx-D_MAFF_KDvsD_C_deg_all-gene_name_MAFF Rummagene Transcription Factor Associations 2026 1.0 null CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.012 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112761,GSE112767_2_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null urine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.31332 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.071991 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05926 POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE243491_1_v_0_oxaliplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22382 Acute Renal Failure Due To Ischemia DisGeNET Gene-Disease Associations 1.0 null FOXA1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.968627 hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null orbital frontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06661 spleen HPA Tissue Gene Expression Profiles 1.0 1.07451 NCIH1793 CCLE Cell Line Gene CNV Profiles 1.0 1.42384 RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5995 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE85302_4_v_1_kat6a_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_10 ENCODE Transcription Factor Binding Site Profiles 1.0 null endometrium_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.23314 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02584 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46334 ZNF528 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.0276 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null LIPE_KO_GDS1318_501_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null KDM5B_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222398 PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_14_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CA-75-HA22_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.3205 CTCF_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null Hemidystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.479 Lung adenocarcinoma_LUAD_TCGA-NJ-A55O-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mavorixafor DeepCoverMOA Drug Mechanisms of Action -1.0 -0.46 GSE101546_2_v_1_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04419 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null macromolecular complex assembly GO Biological Process Annotations 2015 1.0 null SP5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.7288 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.867303 hsa-miR-4319 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.197 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE165636_0_v_4_tofacitinib_human RummaGEO Drug Perturbation Signatures 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.023629 JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE135030_3_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null VCAP_PROSTATE CCLE Cell Line Proteomics 1.0 2.98934 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE243491_1_v_2_oxaliplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14319 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_279_KD_MBNL2_SRP077885 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.39296 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17087 membrane-enclosed lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Hepatomegaly CTD Gene-Disease Associations 1.0 1.47348 Leukemia_chronicMyelogenousK-562 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.23266 primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.831023 ATF3-27146783-CHIP-SEQ-COLON-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE146962_0_v_1_glucosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r2 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2532 protein folding GO Biological Process Annotations 2015 1.0 null striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.917489 HHV8_72Hour-BEC_20080955_GSE16354 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.98632 HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.74672 GSE97278,GSE97280_2_v_3_nsd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE236003_1_v_3_ubr5_human RummaGEO Gene Perturbation Signatures 1.0 null syndrome GeneRIF Biological Term Annotations 1.0 null NCI-H2135 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.3066 GSE236454,GSE236456_0_v_1_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54394 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6326-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null blood cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060359 KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.759191 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Plasmodesma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.815 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null endoplasmic reticulum lumen GO Cellular Component Annotations 2015 1.0 null DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.99703 Congestive Heart Failure DisGeNET Gene-Disease Associations 1.0 null hippocampus (hippocampal formation)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.864473 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOLT-4 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.49511 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70M-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.568988 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null blast cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33024 subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.912758 DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.508925 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.940389 peripheral vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.36704 CDX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19744 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K2-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210476_2_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null SKA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47899 Taenia tecta, dorsal part, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35188 GSE166294_0_v_1_etv5_mouse RummaGEO Gene Perturbation Signatures 1.0 null r6 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6833 GSE81193_3_v_5_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100458_FWM_no dementia_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.27247 RFX5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064816 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050489 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55363 T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.3814 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Endoplasmic reticulum tubular network COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.723 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199204,GSE211619_4_v_0_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null FOXA2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE184892_6_v_1_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null TCF3-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40862 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ELK3_ELK3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.848014 FOXA1_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6022 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7318-01B-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null salusinbeta GeneRIF Biological Term Annotations 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13137 Synovial sarcoma_Synovial Membrane_GSE6461 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.45305 HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07164 Oromandibular dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.891 ZNF341 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1749 lymphoid cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0784 gata4_18812176_jejunum_tissue_lof_mouse_gpl1261_gds3486 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.123485 PMC6977700-aging-12-102667-s004..xlsx-Stage4-The_identified_749_dysregulated_LmiRM-CTs_in_stage_4_of_MI_6_months_after_MI_using_our_method_MITF Rummagene Transcription Factor Associations 2026 1.0 null 8433_SRSF3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.577628 HA-36-VD41_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259716 periventricular stratum of r4Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94649 Microtubule organizing center attachment site COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.086 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 RCH-ACV COSMIC Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JL-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE209938_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null KYSE-150 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.648 PLOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26536 Breast Cancer_Mammary Gland Tissue_GSE1872 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.44583 ARPC5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.40521 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.05694 WM115 DepMap CRISPR Gene Dependency 1.0 2.10017 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180277_0_v_1_bach2_mouse RummaGEO Gene Perturbation Signatures 1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Parkinson disease PANTHER Pathways 1.0 null bypass GeneRIF Biological Term Annotations 1.0 null CAL27 CCLE Cell Line Gene CNV Profiles 1.0 1.35979 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0422 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3383-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.837342 Fetal_Brain_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.953836 Nucleus sagulum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00008 SP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.988867 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RKO CCLE Cell Line Gene CNV Profiles 1.0 1.82226 KMS-21BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32398 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A9-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null Posterior nuclear complex of thalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.659 cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.29923 inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.7197 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF7-22412390-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PET100 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10244 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16535 H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE159148_0_v_1_sdc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null intracellular organelle part GO Cellular Component Annotations 2015 1.0 null amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14333 FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146074_6_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC Rummagene Transcription Factor Associations 2026 1.0 null FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.414726 H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HU-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null monocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.07794 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-125b TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 hsa-miR-1470 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Sublaterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69556 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.975604 GSE210655_1_v_7_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE218949_0_v_1_cep20_human RummaGEO Gene Perturbation Signatures -1.0 null GSE123825_2_v_3_glud1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SH-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.40818 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKMEL24 CCLE Cell Line Gene Expression Profiles -1.0 -2.80049 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LC-12-VN85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219298 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC1-22415368-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A76O-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26508 shell of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36383 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHEMBL383736 DeepCoverMOA Drug Mechanisms of Action 1.0 0.37 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM2B-26808549-CHIP-SEQ-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE127790_10_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular metabolic process GO Biological Process Annotations 2015 1.0 null RFX5_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A2J1-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRY-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE157555,GSE157556_4_v_2_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Nerve Degeneration CTD Gene-Disease Associations 1.0 1.04465 H3K36me3_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GCM2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9053 FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22412 r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.20055 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15259 H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE154577_6_v_12_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.978498 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r4 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94081 GSE154577_13_v_5_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC-78 COSMIC Cell Line Gene Mutation Profiles 1.0 null COR-L32 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.45543 RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3 CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial superior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88544 microcellular tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03673 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I9-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF93 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 122.778 ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04732 motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32631 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42327 endoplasmic reticulum COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 L-Mimosine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.35 CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HIV Infections HuGE Navigator Gene-Phenotype Associations 1.0 null EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251766 BB-77-QQ71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219954 OB-06-WW76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.433322 colonrectum_a HPA Tissue Sample Gene Expression Profiles 1.0 0.913326 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.961929 GSE88819_3_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.29462 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null locally GeneRIF Biological Term Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-EP-A2KA-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.39355 E2F1 ENCODE Transcription Factor Targets 1.0 null 20003503-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2V-A95S-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1276 TRAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1931 NCIH1703 CCLE Cell Line Gene Expression Profiles -1.0 -1.63655 HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.587817 Lung adenocarcinoma_LUAD_TCGA-86-A4JF-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.960154 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WH-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199660_1_v_3_secretin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.09395 MAX ENCODE Transcription Factor Targets 1.0 null OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05451 GSE216273,GSE216292_0_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null CA-68-TC79_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.216306 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.77326 MCF7_SL-327_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143767 ELK3-25401928-HUVEC-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.57638 GSE168596_2_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.112527 GATA3-21867929-TH1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14666 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0422 JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lymphoid cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053335 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6396 Kufor-Rakeb syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.021 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31726 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47M-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Uterine Cervical Neoplasms CTD Gene-Disease Associations 1.0 1.05828 DE-34-DT75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257659 GSE130396_8_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1599 CCLE Cell Line Gene CNV Profiles 1.0 1.34434 WM88_SKIN CCLE Cell Line Proteomics 1.0 2.26433 CTCF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null peptide GeneRIF Biological Term Annotations 1.0 null blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null R121919 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.48 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Accessory olfactory bulb, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31773 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Blepharospasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.366 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04089 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3 ENCODE Transcription Factor Targets 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MFE-280 COSMIC Cell Line Gene Mutation Profiles 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Substantia nigra, reticular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02294 ChIP_ZFX_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RT112 DepMap CRISPR Gene Dependency 1.0 2.00093 r1 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10548 ZC3H11A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SPC25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11012 RORA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.3556 PCM6 CCLE Cell Line Gene Expression Profiles 1.0 2.50642 SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hereditary spastic paraplegia 35 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.209 CTCF_GM12868_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE86507,GSE86509_0_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsal subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05779 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRIM28 ENCODE Transcription Factor Targets 1.0 null NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.78893 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48543 GFI1B ChEA Transcription Factor Targets 1.0 null GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ion binding GO Molecular Function Annotations 2015 1.0 null TEAD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7891 excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052839 molecular layer of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3942 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Plant scale TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.1 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null DND41 CCLE Cell Line Gene Expression Profiles 1.0 1.45119 EP300_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.02473 GP2D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Perturb_5919_KD_KAP1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.88183 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ATF3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.00983 Secondary Malignant Neoplasm Of Lymph Node DisGeNET Gene-Disease Associations 1.0 null GSE108614,GSE108615_3_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12127 DA-20-VR86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.804078 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE216538_7_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNU349 CCLE Cell Line Gene CNV Profiles -1.0 -1.46531 BD-96-HO33_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266444 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K7-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18414 EKVX Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.22921 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell culture TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.079739 KMS12BM CCLE Cell Line Gene Expression Profiles 1.0 2.01968 CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Macrophage foam cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.706 PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF Rummagene Transcription Factor Associations 2026 1.0 null TE-8 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.97768 FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.428308 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9587_UMPS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.635172 monocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.074766 UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46334 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC7064337-elife-51373-supp2.xlsx-847_genes_down-regulated-List_of_847_genes_down-regulated_after_PHF19_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE138672_0_v_1_rabgef1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80681 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3725-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8387919-mmc2.xlsx-ST8_NEUROG3_and_islets_expr-Unnamed_2_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null BLUE1 DepMap CRISPR Gene Dependency 1.0 2.11295 CMTR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03864 MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.234 r2 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34696 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01609 MDST8_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 2.08209 eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.42348 periventricular stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71311 5860_NUDCD3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.726693 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.23051 MRPL17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77049 layer 5 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00034 GLE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1805 hsa-miR-744-5p MiRTarBase microRNA Targets 1.0 null GSE199204,GSE211619_4_v_3_glutamine_human RummaGEO Drug Perturbation Signatures -1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.62932 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L6-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4281 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 AC-84-QG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227632 KLF4-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null r3 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55515 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Infertility, Female CTD Gene-Disease Associations 1.0 1.05274 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gigantocellular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.85286 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null r3 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17998 Dentate gyrus, granule cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59874 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-A4AQ-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54072 GSE220058,GSE220059_0_v_1_prrc2b_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF404 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86627 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null 496100402_FWM_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.99096 testis_7e HPA Tissue Sample Gene Expression Profiles 1.0 0.8253 TTF2-22483619-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE231641_0_v_1_robo1_mouse RummaGEO Gene Perturbation Signatures -1.0 null disease of metabolism GWASdb SNP-Disease Associations 1.0 0.076282 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44769 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12867_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRSF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02061 Lung adenocarcinoma_LUAD_TCGA-50-6597-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PBX-27287812-CHIP-SEQ-EMBYONIC-LIMB-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE127790_6_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.42951 inner portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30127 GSE211286_1_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01997 UBB_KO_GDS3906_491_mouse_Testis - 7 Days GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.955715 QA-07-KC40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.351851 medial tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00048