association dataset threshold value standardized value thyroid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.105997 CLDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99861 CRCGN017_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9699 BRD-K03221986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35173 Striate cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.254 Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.562 TSH producing pituitary tumor DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.498 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Metencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.474 hormoneinduced GeneRIF Biological Term Annotations 1.0 null BRD-K63415335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21229 Histaminergic neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.861 Inferior colliculus, dorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28209 TEPSIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89934 GSE253041_1_v_0_ramp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null protein-processing-post-translational Phosphosite Textmining Biological Term Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07005 MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.984237 contribute GeneRIF Biological Term Annotations 1.0 null preferential GeneRIF Biological Term Annotations 1.0 null intermediate stratum of PHyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07092 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SF-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26A-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.059 Hypervitaminosis A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 BRD-K81575721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0037 BRD-K57786028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18211 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46D-01A-21R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neck TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.243 PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-T3M4_KLF5_activated_H3K27ac_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_8951_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 CRCGN014_HEPG2_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6361 amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.857149 NAP1L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13119 gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.680656 SNRNP40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48332 TAF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08334 SNU878 CCLE Cell Line Gene Expression Profiles 1.0 2.14481 POU3F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63321 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Pulse pressure GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.25229 viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045711 osteoporosis GWASdb SNP-Disease Associations 1.0 1.53704 B3GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07339 abnormality of the thyroid gland HPO Gene-Disease Associations 1.0 null Cytoplasmic side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.228 Thyroid gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.319 CRCGN014_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.41825 disease of mental health GWASdb SNP-Disease Associations 1.0 0.109591 agranular insular cortex (area Iag) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08157 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Z-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8516 NAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12169 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.88614 TRIM LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.03662 GSE164364_0_v_1_zymosan_mouse RummaGEO Drug Perturbation Signatures -1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6882-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAKI1 BioGPS Cell Line Gene Expression Profiles 1.0 1.14591 Hypothalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.149 CNOT6L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51237 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16438 MARCHF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1057 CYRIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55858 MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03916 PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.52942 HEYA8 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.00968 BRD-K07414059 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.5939 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.379 ZNF239 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.73922 BRD-K48744855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.135 ovary TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.322414 potentiates GeneRIF Biological Term Annotations 1.0 null RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44298 CAMK2N2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96251 interstitial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.448346 Anterior lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.231 medial amygdala, anterodorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09948 BRD-A95207036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.976 Anterior commissure TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.739 Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01772 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN016_MCF10A.TP53.M_24H:O18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.88379 BRD-K89574562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24039 increased anxiety-related response MGI Mouse Phenotype Associations 2023 1.0 null BRD-K18149487 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50613 parastrial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19029 membrane GeneRIF Biological Term Annotations 1.0 null BRD-K16387460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1256 transverse gyri, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11755 abnormality of head or neck HPO Gene-Disease Associations 1.0 null CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.79345 CCDC137 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14649 GSE201042_6_v_4_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Nerve Degeneration CTD Gene-Disease Associations 1.0 1.06225 ANKIB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07576 CRCGN014_HEPG2_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.77639 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null MFSD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66015 integral component of plasma membrane GO Cellular Component Annotations 2015 1.0 null SBK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36211 GIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33838 Prostate adenocarcinoma_PRAD_TCGA-G9-6385-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adenoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.613 pars distalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.236627 HSC-3 GDSC Cell Line Gene Expression Profiles 1.0 1.51905 MZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.80782 abnormality of higher mental function GWASdb SNP-Phenotype Associations 1.0 0.256762 muscle tissue disease GWASdb SNP-Disease Associations 1.0 0.37196 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31912 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z0-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K53224741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20524 accessory olfactory bulb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.387781 membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.867206 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.6813 Mandibular organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.634 496100572_HIP_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.26693 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A5RQ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HTT-18923047-STHdh-human ChEA Transcription Factor Binding Site Profiles 1.0 null bone disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.670996 MEF-2 MotifMap Predicted Transcription Factor Targets 1.0 null HMC18 CCLE Cell Line Gene Expression Profiles 1.0 1.82739 RBMX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40668 GSE253089_0_v_1_ephb2_human RummaGEO Gene Perturbation Signatures 1.0 null Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary motor area, Layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.79816 molecular transducer activity GO Molecular Function Annotations 2015 1.0 null ZNF341 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70018 RAB39B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44838 GSE251992_1_v_0_saracatinib_human RummaGEO Drug Perturbation Signatures -1.0 null EGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18371 NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.273 abnormal circulating ghrelin level MGI Mouse Phenotype Associations 2023 1.0 null Pituitary gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.155 CCNL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46479 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.960103 Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NDUFS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41643 skin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054059 U-266 COSMIC Cell Line Gene Mutation Profiles 1.0 null FHDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66576 Hypothyroidism CTD Gene-Disease Associations 1.0 2.88009 recycling GeneRIF Biological Term Annotations 1.0 null trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.40471 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.912713 ADAMTS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25943 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.914676 superficial stratum of PHyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46087 BRD-K61943321 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43839 thalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07114 nucleus of the stria terminalis, medial division, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1181 CRCGN016_MCF10A.WT.HP_24H:D04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.7858 BRD-K17367110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59827 cytoplasmic membrane-bounded vesicle LOCATE Curated Protein Localization Annotations 1.0 null THOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11415 Epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.157 CRCGN008_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7062 hormone GeneRIF Biological Term Annotations 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B7-01A-31R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13052_KO_Il17a_SRP268747 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.65677 ESET_KO_GDS4508_348_mouse_Dorsal telencephalon from E14.5 embryos GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MED21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80863 Thyroid gland disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 CRCGN015_MCF10A.WT.HP_24H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3282 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.219 Lateral posterior nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.916 SLC2A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81811 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-8216-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2052 GDSC Cell Line Gene Expression Profiles 1.0 1.58835 BRD-A77164655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50813 macrophage BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.858068 cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.747737 intermediate stratum of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16207 FNDC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.40688 CHEMBL:CHEMBL585654 DGIdb Drug Targets 2026 1.0 1.51234 BRD-K77578964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.73106 Prolactinoma DisGeNET Gene-Disease Associations 1.0 null TMEM190 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31277 ITPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71932 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.915469 RINL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36105 PMC12619835-41467_2025_66007_MOESM12_ESM.xlsx-KLF5_activated_H3K27ac_T3M4-Nearest_Gene_Name_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null Laterodorsal thalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.957 Congenital Exomphalos DisGeNET Gene-Disease Associations 1.0 null SMRT-22465074-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Skeletal muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.723 Pancreatic adenocarcinoma_PAAD_TCGA-XN-A8T5-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47005 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MR-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7PW-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Olfactory bulb TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.552 Thyroid Hormone Resistance Syndrome CTD Gene-Disease Associations 1.0 2.88009 BRD-A60877539 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71305 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.867952 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MDAMB361 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.59464 PHF20L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40485 CTAGE6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9923 UNKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38826 decreased circulating levels of thyroid hormone MPO Gene-Phenotype Associations 1.0 null casein Phosphosite Textmining Biological Term Annotations 1.0 null BRD-A61522392 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78175 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52219 BRD-K84199148 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34911 UPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2626 LN443 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.32443 Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_6_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Anterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62707 HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.935555 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.52865 Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RP-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paraventricular nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65058 RBM12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61759 principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42183 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0493 CRCGN014_HEPG2_24H:A03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.21579 Perturb_12861_KO_Clec4d_SRP282597 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.54126 OVOL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42741 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RO-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.85979 BRD-K39859838 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4375 PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S9-ZNF384_SpecDMCs-Unnamed_3_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null Hypophysis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.541 behavioral abnormality HPO Gene-Disease Associations 1.0 null HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.76567 Leukemialymphoblastic(MOLT-4) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.866945 CTDNEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78223 RNF187 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70543 sleep disturbance HPO Gene-Disease Associations 1.0 null NR6A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.15296 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54724 Inhibin B complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.124 CRCGN017_MCF10A.TP53.M_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.02455 GSE238018_1_v_2_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K31992830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1506 Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.092 TBX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35593 intrinsic component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K52688277 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19639 gata1_15895080_e12dot5_liver_megakaryocyte_lof_mouse_gpl1261_gds1316 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.027491 CRCGN016_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.214 Epilepsies, Myoclonic CTD Gene-Disease Associations 1.0 1.04611 Endocrine system disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 abnormal anxiety-related response MPO Gene-Phenotype Associations 1.0 null Cell type benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.371 OE33 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.24597 CRCGN014_HEPG2_3H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.16785 DOT1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55636 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.463 PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5 Rummagene Transcription Factor Associations 2026 1.0 null QGP1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.2754 Movement Disorders CTD Gene-Disease Associations 1.0 1.01625 FAM200A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60822 BRD-K63212062 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.68302 OGFOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53959 BRD-K60444040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05523 hematological GAD High Level Gene-Disease Associations 1.0 0.293278 G protein-coupled receptor, rhodopsin-like InterPro Predicted Protein Domain Annotations 1.0 null H3K27me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMT2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96041 administration GeneRIF Biological Term Annotations 1.0 null muscular disease GWASdb SNP-Disease Associations 1.0 0.348788 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.969 ELF5 ChEA Transcription Factor Targets 1.0 null H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Hypothyroidism DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.65702 SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2929 BRD-K22789469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.27047 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.894 dimerization GeneRIF Biological Term Annotations 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4R8-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KIF2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98209 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -0.901498 Bacterial nucleoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.322 Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67657 CRCGN012_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6169 NOTCH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86416 Biceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.751 membrane-bounded vesicle LOCATE Curated Protein Localization Annotations 1.0 null INPP5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31147 BRD-K37386363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28325 hippocampus (hippocampal formation)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14119 BRD-A98888138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5156 HCC202 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.07718 CX-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.699 LDL cholesterol levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.730103 Neural crest cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.086 Olfactory lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.551 Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.051 DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K73357447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.41533 GSE126345_9_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null abnormality of connective tissue HPO Gene-Disease Associations 1.0 null COLO-800 COSMIC Cell Line Gene Mutation Profiles 1.0 null WDR44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.62421 Thyroid Neoplasms HuGE Navigator Gene-Phenotype Associations 1.0 null integral component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.783698 GUSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42757 ZNF275 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89632 GATA1 ChEA Transcription Factor Targets 1.0 null S-isopropylisothiourea LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.30701 TBX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64093 PPM1J CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1606 GOS3 CCLE Cell Line Gene Expression Profiles 1.0 1.50327 BRD-A74152721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15271 ventrolateral prefrontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.962721 UMUC3 DepMap CRISPR Gene Dependency 1.0 3.65036 abnormality of the tongue HPO Gene-Disease Associations 1.0 null CRCGN009_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.14856 ENDOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5815 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07794 DHX9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89795 SNU719 CCLE Cell Line Gene Expression Profiles -1.0 -2.21317 C9orf78 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0238 ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04446 496100548_HIP_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0572 abnormality of the abdominal wall HPO Gene-Disease Associations 1.0 null exposure Phosphosite Textmining Biological Term Annotations 1.0 null RBM18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60138 adenomas GeneRIF Biological Term Annotations 1.0 null DYNC1LI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20117 CRCGN013_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16245 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43854 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046422 SHISA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28329 spine apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.258381 Signaling by GPCR Reactome Pathways 2024 1.0 null Corticotropic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.689 CRCGN012_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.20389 motoneuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.510992 Perturb_13021_KO_ALOX5_SRP367905 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.92685 CRCGN011_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.47185 TFE3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0398 habenula (old epithalamus) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16129 GSE221004_1_v_2_prdm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null TSC1_Deficiency_GDS4572_346_mouse_Naive CD4 T cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null caudal subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00756 MeTRH Guide to Pharmacology Chemical Ligands of Receptors 1.0 null BRD-K06002536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21128 Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.89348 foxa2_20483781_p15_lung_lof_mouse_gpl1261_gse19204 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.041949 TTC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9452 testicular cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.512957 Sarcoma_SARC_TCGA-DX-A2J0-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.81925 GSE219274,GSE219276_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.55237 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10137 BRD-K63716942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40985 GSE142630_0_v_2_hiltonol_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH2052 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.25889 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KP-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Subiculum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.195 YEATS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78897 SNU81 CCLE Cell Line Gene Expression Profiles -1.0 -1.47748 PMC8192774__F3 PFOCR Pathway Figure Associations 2024 1.0 null germ cell cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.178682 GSE187006_0_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE162590_1_v_0_gsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47308 DMNB LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84689 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.747737 Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91033 CYB5RL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39249 GABPA_01_190 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 10.0484 BRD-K26992703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39432 NFKBID CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94591 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08007 Medial amygdalar nucleus, anterodorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.86251 BRD-K57537921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13721 GSE140607_0_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K68574010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13822 neuroendocrine tumor DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.451078 clathrin-coated pit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.07 SUPM2 CCLE Cell Line Gene Expression Profiles 1.0 1.60728 OPM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.5402 INSM1_KO_GDS5066_472_mouse_pituitary gland GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Daudi GDSC Cell Line Gene Expression Profiles 1.0 2.60283 CRCGN014_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.73981 SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.824657 BV-173 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44905 GMS-10 GDSC Cell Line Gene Expression Profiles -1.0 -1.45006 Perturb_8944_KO_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.12214 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Axon collateral COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.578 PMC5543043-data_sheet_2.xlsx-LPS_MDM_module-Upstream_Regulator_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null determined GeneRIF Biological Term Annotations 1.0 null ZNF883 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78362 MAFK_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A913-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amorolfine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81085 CRCGN017_MCF10A.TP53.M_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.0109 TC71 CCLE Cell Line Gene CNV Profiles 1.0 1.67596 BRD-K46014233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24699 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NS-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.51301 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.34723 BRD-K28195874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15526 increased circulating glucose level MPO Gene-Phenotype Associations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H510A COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 Autoimmune thyroiditis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.157 UBE2L6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80719 Cortical amygdalar area, posterior part, medial zone, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52338 GSE239898,GSE239899_1_v_0_hiltonol_human RummaGEO Drug Perturbation Signatures 1.0 null mantle zone of PSPa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22535 BRD-K46141002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08888 MN-60 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7794-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6961892__F7 PFOCR Pathway Figure Associations 2023 1.0 null BRD-K56032186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06081 Hypotension CTD Gene-Disease Associations 1.0 1.15729 EOL-1-CELL COSMIC Cell Line Gene Mutation Profiles 1.0 null GIGYF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23161 Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8399 PRKAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64943 CRCGN008_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.96875 BRD-K58779593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.16431 BRD-K55135464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08659 CRCGN015_HEPG2_48H:M17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.00135 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4703-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.513417 Signaling by GPCR Reactome Pathways 2014 1.0 null Anterior hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.9483 Nr2e1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.8241 BRD-K50443235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.04193 Bipolar cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.425 postcentral gyrus, left, superior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.972726 internal granular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11067 CRCGN011_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3693 Thyroid follicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.555 BRD-K11310449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34648 hindbrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.70296 GSE123958,GSE123959_0_v_1_mta1_human RummaGEO Gene Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A3JM-01A-12R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.5843 Corpus albicans TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.995 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GATA1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null WASHC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53296 molecular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36962 Retrosplenial region TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.637 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.36587 GSE81803,GSE81912_2_v_1_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HOXD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.39323 BRD-K47636083 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04593 LIPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30422 membrane part GO Cellular Component Annotations 2015 1.0 null ZSCAN16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.4923 Sox1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.4229 USP22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.64339 K562 CCLE Cell Line Gene Expression Profiles 1.0 1.4222 ATR_knockdown_140_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.09902 amino GeneRIF Biological Term Annotations 1.0 null BRD-A61864215 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.16015 CRCGN014_HEPG2_3H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.97346 BRD-K92372829 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26447 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.75809 Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.543 BRD-A67508925 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.55068 CRCGN010_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.7223 superficial stratum of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6236 r3 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1051 Lateral geniculate body TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.72 cerebral cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070034 PDZD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27929 primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40877 Generalized Hypotonia DisGeNET Gene-Phenotype Associations 1.0 null C7orf50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54262 BRD-K76175734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13794 Thyroid hormone resistance syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.676 PNO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11234 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5194-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMAD4-21799915-A2780-HUMAN ChEA Transcription Factor Targets 2022 1.0 null central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.93258 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5978-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV1-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TNNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.8067 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.873243 intrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.128241 Prostate adenocarcinoma_PRAD_TCGA-EJ-7315-01A-31R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null arginine Phosphosite Textmining Biological Term Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2790-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.175188 H3K27me3_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZR-75-30 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 CRCGN016_MCF10A.WT.HP_24H:O24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.62616 retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66775 cuneus, left, peristriate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21379 RUNX2_NULL MUTATION_GDS2184_719_mouse_Embryonal bone (MG-U74A) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CRCGN016_MCF10A.TP53.M_24H:P18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56548 layer 2 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26498 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.112 paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.22746 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7645-01A-22R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Metabolic disorders of biological oxidation enzymes Reactome Pathways 2014 1.0 null CL11 DepMap CRISPR Gene Dependency 1.0 2.83979 Liver hepatocellular carcinoma_LIHC_TCGA-5C-A9VH-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K28107038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38044 LN-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K65529782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26113 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47005 SLR25 CCLE Cell Line Gene Expression Profiles -1.0 -1.92112 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4344-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210885_0_v_7_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null retrohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07225 intracellular COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.682899 PJA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30598 CRCGN016_MCF10A.TP53.M_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.51863 MINDY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99218 mantle zone of VAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15124 CRCGN016_MCF10A.TP53.M_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52585 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.961759 WDR89 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19429 acid GeneRIF Biological Term Annotations 1.0 null RPE1SS6 DepMap CRISPR Gene Dependency 1.0 2.13444 bromopride LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.38071 RNF112 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13179 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SN-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125155_3_v_1_mecp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8911152__F2 PFOCR Pathway Figure Associations 2024 1.0 null abnormal prolactin level MPO Gene-Phenotype Associations 1.0 null inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886933 Hypopituitarism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.158 CRCGN015_HEPG2_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.78793 tm-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.733089 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.66727 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.418 CRCGN012_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59543 dorsolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.905335 abnormality of the liver HPO Gene-Disease Associations 1.0 null EIF3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38894 Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31210612 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08127 nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042444 [3H]MeTRH Guide to Pharmacology Chemical Ligands of Receptors 1.0 null CRCGN009_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.20805 RC3H2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55941 NCIH446 CCLE Cell Line Gene Expression Profiles 1.0 2.57418 Perturb_13017_KO_ALOX5_SRP367905 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.66989 PMC10891343-mmc2.xlsx-FIP_ToxCast_Raw-GENE_SYMBOLS_USF2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.86865 Brain Lower Grade Glioma_LGG_TCGA-HT-7692-01A-12R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52340217 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28808 PBX1 ChEA Transcription Factor Targets 1.0 null musculoskeletal system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.670996 abnormal thyroxine level MPO Gene-Phenotype Associations 1.0 null GDAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38578 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CH-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal circulating pituitary hormone level MPO Gene-Phenotype Associations 1.0 null GSE230263,GSE230265_5_v_1_runx1_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.24109 ala Phosphosite Textmining Biological Term Annotations 1.0 null PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null FOXB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21957 ZNF519 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75528 ALVA31 BioGPS Cell Line Gene Expression Profiles 1.0 1.222 CRCGN015_HEPG2_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1076 BRD-K97949309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31476 BRD-K28953184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05597 Benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.384 PMC10916124-12864_2024_10174_MOESM1_ESM.xlsx-Supplementary_Table_6-The_downstream_genes_targeted_by_FLI1_The_ligand_vs_receptor_pairs_genes_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null ERCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44698 FNBP1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47569 BRD-K86722849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37913 abnormality of nervous system physiology HPO Gene-Disease Associations 1.0 null HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.01238 decreased pituitary hormone level MPO Gene-Phenotype Associations 1.0 null Brn3a_KO_GDS1651_247_mouse_Embryonic (day 13.5) trigeminal ganglia - heterozygous GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_766_mouse_Skin - 0 Day GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 496100321_HIP_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00605 ATP5F1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03247 Placenta TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NCI-H2023 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.917459 HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11572 frontal lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.084863 PIAS1-25552417-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KG-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K20799008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92595 M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04604 CRCGN009_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.61295 SIRT1_Deficiency_GDS4895_316_mouse_Brain GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null DARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59513 CRCGN014_HEPG2_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8531 Inhibin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.021 HAPSTR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53655 Perturb_8948_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.1851 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.16471 CRCGN014_HEPG2_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.41038 Psychomotor Agitation CTD Gene-Disease Associations 1.0 1.06406 PMC5817105-thnov08p0972s2.xls-SIX3_LSD1-GeneName_SIX3 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN010_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51954 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.59 pka Phosphosite Textmining Biological Term Annotations 1.0 null GSE153137,GSE153140_2_v_1_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Paraventricular nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.466 ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.899 Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Congenital mirror movement disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.013 Supraoptic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.015 Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4104-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IGSF1 deficiency syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.8 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23729 Neurohypophysis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.396 Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.226 outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.863363 Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.3778 ISTMES2 CCLE Cell Line Gene CNV Profiles -1.0 -1.81737 MDA MB435 BioGPS Cell Line Gene Expression Profiles -1.0 -0.948481 Rheaume et al.Nat Commun.31_Retina_Mouse CellMarker Gene-Cell Type Associations 1.0 null GSE189772,GSE189773_3_v_2_fbxo11_human RummaGEO Gene Perturbation Signatures 1.0 null NTERA-2_CL_D1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08702 membrane Phosphosite Textmining Biological Term Annotations 1.0 null BTG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80699 Cortical amygdalar area, posterior part, medial zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77806 SCAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52461 TOR1AIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93333 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.995163 olivary pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51772 CHD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36837 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.37269 ITGA7_OE_GDS3209_142_mouse_skeletal muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JT-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RRP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17368 Zona incerta TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.587 MFSD14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.97798 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01366 ACSBG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.99536 Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.888664 SKIDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02125 PITPNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.887 cuneiform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21976 Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHMP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45458 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.70015 CRCGN015_HEPG2_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 female Phosphosite Textmining Biological Term Annotations 1.0 null Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.478 decreased circulating triiodothyronine level MGI Mouse Phenotype Associations 2023 1.0 null BRD-K49525275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12117 HARBI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55987 BRD-K01278504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42016 neuron part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046417 Thyrotropin-releasing hormone receptor InterPro Predicted Protein Domain Annotations 1.0 null Throat TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.277 Arcuate nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.028 HNF4A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.7919 Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61718 PLXNB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.674 abnormal blood homeostasis MPO Gene-Phenotype Associations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAB11FIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.433 NCIH2171 CCLE Cell Line Gene CNV Profiles -1.0 -1.54167 decreased triiodothyronine level MPO Gene-Phenotype Associations 1.0 null POU3F2-20337985-501MEL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Paraventricular hypothalamic nucleus, parvicellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01002 periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15397 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8927 CRCGN015_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14626 CRCGN017_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29528 SNCG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64903 membrane LOCATE Curated Protein Localization Annotations 1.0 null targeting Phosphosite Textmining Biological Term Annotations 1.0 null PASK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22601 medial part of MPO Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05833 BRD-K86453556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.26292 CRCGN017_MCF10A.WT.HP_24H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6837 cytoplasmic Phosphosite Textmining Biological Term Annotations 1.0 null sertoli cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.229299 behavioral despair MGI Mouse Phenotype Associations 2023 1.0 null MM1S CCLE Cell Line Gene CNV Profiles -1.0 -2.05607 TM-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.149 behavior/neurological phenotype MPO Gene-Phenotype Associations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR2F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88045 PAX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39549 subcuneiform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.826955 BRD-K48308783 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01205 turnover Phosphosite Textmining Biological Term Annotations 1.0 null BMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44319 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.51749 R3HCC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49923 Sox17 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.3173 Perturb_4166_KO_Bcl11a_SRP334609 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07183 adrenal gland hyperfunction DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.138059 STMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32284 PYDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26057 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null limbic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.312957 Congenital Central Hypothyroidism DisGeNET Gene-Disease Associations 1.0 null FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2295 H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cysteine Phosphosite Textmining Biological Term Annotations 1.0 null Lethargy CTD Gene-Disease Associations 1.0 1.08478 adiposity GAD Gene-Disease Associations 1.0 null Thyroid Hormone Resistance Syndrome DisGeNET Gene-Disease Associations 1.0 null hyperpituitarism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.152215 SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.6568 UBL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48348 HCC2935 CCLE Cell Line Gene CNV Profiles -1.0 -1.98576 SRSF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6937 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.720351 hair shaft TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.275094 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null furazolidone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72691 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.833827 FANCG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03926 layer 3 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13131 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51T-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Accessory olfactory bulb TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.034 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-6720-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gh4-c1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.8322 lateral parabrachial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19387 BRD-K37403152 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28067 GSE216523_1_v_0_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH660 CCLE Cell Line Gene CNV Profiles 1.0 1.4831 Brain stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.433 Thalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.673 ISTMES1 CCLE Cell Line Gene Expression Profiles 1.0 1.47556 MRPL27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95651 Prostate adenocarcinoma_PRAD_TCGA-EJ-7785-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.3074 Cortical amygdalar area, posterior part, lateral zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76663 Weight Loss CTD Gene-Disease Associations 1.0 1.56875 UACC812 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.47052 NCI-H1573 GDSC Cell Line Gene Expression Profiles 1.0 1.66491 decreased thyroxine level MPO Gene-Phenotype Associations 1.0 null Psychoses, Substance-Induced CTD Gene-Disease Associations 1.0 1.07875 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4161-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Postpiriform transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09048 artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044594 medial parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37732 Pt-K2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.908 CCL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21692 EZH2 ENCODE Transcription Factor Targets 1.0 null SOWAHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.8585 Diencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.147 CRCGN012_HEPG2_24H:G07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.89097 CRCGN014_HEPG2_3H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53921 HT55 Achilles Cell Line Gene Essentiality Profiles 1.0 1.79129 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M5-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28707 cerebellar nuclei of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09824 ETAA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.51151 embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Prolactinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.35 Peptide ligand-binding receptors Reactome Pathways 2024 1.0 null EFM192A CCLE Cell Line Gene CNV Profiles 1.0 1.45887 Intracranial Hypertension CTD Gene-Disease Associations 1.0 1.01062 Brain Lower Grade Glioma_LGG_TCGA-DU-A76R-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.1308 subthalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.89697 Prostate adenocarcinoma_PRAD_TCGA-HC-7821-01A-12R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5097-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K02106348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09854 NOP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43024 BRD-K18077898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22311 Goiter DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.703 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.41155 BRD-K76521932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22025 Psychotic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.217 SAMD14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05922 G alpha (q) signalling events Reactome Pathways 2024 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.6178 Basomedial amygdalar nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48114 zonal layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21353 Prostate adenocarcinoma_PRAD_TCGA-EJ-5496-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46002 POU3F2 ChEA Transcription Factor Targets 1.0 null CRCGN011_HEPG2_24H:H06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03615 Respiratory Insufficiency CTD Gene-Disease Associations 1.0 1.13862 accumbens nucleus, core domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21967 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.548914 KURAMOCHI COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 BRD-K48195722 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09371 SP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77759 CAS1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.42133 BRD-K06459664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30994 BRD-K24387065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12846 SYCP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11375 prevented GeneRIF Biological Term Annotations 1.0 null CRCGN017_MCF10A.WT.HP_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.16139 GSE74490_0_v_1_triptolide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Schizophrenia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 Alzheimer's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.271 medial amygdala, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90759 BRD-K14090520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18703 TMEM256 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36728 Estazolam CTD Gene-Chemical Interactions 1.0 null HCC2998 DepMap CRISPR Gene Dependency 1.0 5.43146 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5218 TPM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4851 BRD-K70923850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63504 GSE164364_0_v_3_zymosan_mouse RummaGEO Drug Perturbation Signatures -1.0 null H2AC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43353 GPKOW CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03336 thyroid GTEx Tissue Gene Expression Profiles 1.0 1.10664 Hypertension HuGE Navigator Gene-Phenotype Associations 1.0 null SNU886 DepMap CRISPR Gene Dependency 1.0 3.59994 mammalian Phosphosite Textmining Biological Term Annotations 1.0 null CRCGN017_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.33132 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.58962 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CR-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.554876 G6PD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74734 decreased circulating thyroxine level MGI Mouse Phenotype Associations 2023 1.0 null FANCE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.622 g-protein-coupled Phosphosite Textmining Biological Term Annotations 1.0 null BRD-K83365102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35985 GPCR, rhodopsin-like, 7TM InterPro Predicted Protein Domain Annotations 1.0 null CRCGN014_HEPG2_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.3129 increased circulating ghrelin level MGI Mouse Phenotype Associations 2023 1.0 null Medial amygdalar nucleus, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.65328 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4505 YD15 CCLE Cell Line Gene CNV Profiles -1.0 -1.53675 GSE183994_3_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ADRA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07334 EFM19 Achilles Cell Line Gene Essentiality Profiles 1.0 1.31375 Anterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14549 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06006 HOXB5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.861 CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.2895 posteromedial cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52863 BRD-K03602135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.30478 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 betamethasone-valerate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52209 OGT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74179 LN235 CCLE Cell Line Gene Expression Profiles -1.0 -1.61502 CRCGN015_MCF10A_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.54595 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XJ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hindbrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 cytoplasmic GeneRIF Biological Term Annotations 1.0 null BRD-K76960970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66077 AtT-20 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.696 CRCGN008_HEPG2_24H:C11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.112 TCF4-23295773-U87-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.35249 r1 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08281 HAUS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70929 DOV13 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K67137502 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62699 Cholesterol dbGAP Gene-Trait Associations 1.0 0.133714 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.562 Sleep Initiation and Maintenance Disorders CTD Gene-Disease Associations 1.0 1.1529 BRWD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67141 BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.560505 Pituitary gland benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.725 Hnf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.3187 NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.882292 spinal cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.342233 BRD-K53401077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80465 NCIH508 Achilles Cell Line Gene Essentiality Profiles 1.0 1.62988 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.959864 weight loss MGI Mouse Phenotype Associations 2023 1.0 null younger GeneRIF Biological Term Annotations 1.0 null Hormone signaling KEGG Pathways 2026 1.0 null GAPVD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42448 CRCGN015_HEPG2_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.95358 TROAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60205 Hepatomegaly CTD Gene-Disease Associations 1.0 1.04647 NKX2-8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4273 ZCCHC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50816 umbilicalcord BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.884196 vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.385436 STAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16191 YH13 CCLE Cell Line Gene Expression Profiles -1.0 -2.19483 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77O-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1968 GSE217776,GSE217829_4_v_6_sgf29_human RummaGEO Gene Perturbation Signatures -1.0 null GSE221327_5_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13111 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.951787 BRD-K08199068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41559 Fastigial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06891 Perturb_7878_KD_CPSF3_SRP266190 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.77126 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11572 BRD-K97588749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16028 POU3F2-20337985-501MEL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null MCMBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56178 integral component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.278509 496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.25195 CRCGN014_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7708 IRX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97114 BRD-M97109212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05851 Bed nuclei of the stria terminalis, anterior division, magnocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07048 AS3MT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76768 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.853 THYROTROPIN-RELEASING HORMONE DGIdb Drug Targets 2026 1.0 15.1234 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.284032 Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.272 DDX21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09039 Feeding Difficulties DisGeNET Gene-Phenotype Associations 1.0 null Type 2 diabetes GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 CALU1 Achilles Cell Line Gene Essentiality Profiles -1.0 -3.55701 TWIST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32192 Sox3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.9749 NUGC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null RS411 Achilles Cell Line Gene Essentiality Profiles 1.0 1.05453 neck TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.824849 BRD-K31204557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56674 SW1271 CCLE Cell Line Gene Expression Profiles -1.0 -1.80386 20460173-ImmPortCytokineReceptors GeneSigDB Published Gene Signatures 1.0 null GSE171292_6_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K60918542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13157 BRD-A77907596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05409 posterobasal nucleus, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41976 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.076 Circumventricular organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.366 Side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.251 Adrenal gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.078 BRD-A69950438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14066 TBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1508 abnormality of muscle physiology HPO Gene-Disease Associations 1.0 null magnocellular (medial) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40646 ZNF208 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6389 BRD-K47690679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05336 receptors GeneRIF Biological Term Annotations 1.0 null hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.46387 GPCR downstream signalling Reactome Pathways 2024 1.0 null hippocampus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.096445 ZNF90 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65849 CRCGN014_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.70322 Pituicyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.292 growth abnormality GWASdb SNP-Phenotype Associations 1.0 1.38847 CRCGN009_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.46134 CRCGN017_MCF10A.WT.HP_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8166 Cerebellum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 P30-OHK COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC5817105-thnov08p0972s2.xls-SIX3-GeneName_SIX3 Rummagene Transcription Factor Associations 2026 1.0 null EMP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.87587 GPX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85387 18801183-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null ZNF346 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.40442 HTT ChEA Transcription Factor Targets 1.0 null Perturb_7509_OE_ILF3_SRP195616 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.44523 STRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3869 BBS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63317 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03463 SCCOHT1 DepMap CRISPR Gene Dependency 1.0 6.83659 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.739 ETV2-25802403-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Superior colliculus, sensory related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56122 hypothyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.35289 substrates GeneRIF Biological Term Annotations 1.0 null Adiposity dbGAP Gene-Trait Associations 1.0 0.897125 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GAMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58247 USP21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30845 PNPLA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39191 MCCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10514 DPYSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61494 Tcof1_KD_GDS998_155_mouse_neuroblastoma N1E-115 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.12855 SLC38A7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24686 Intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.274 Entorhinal area TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.577 basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.954986 BRD-K86630280 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58038 paracentral lobule, anterior part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.83315 periventricular stratum of RtC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07313 GSE123105,GSE124556_0_v_2_pcf11_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.63979 abnormal circulating gonadotropin level MPO Gene-Phenotype Associations 1.0 null Allan-Herndon-Dudley syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 CRCGN010_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69775 LS123 DepMap CRISPR Gene Dependency 1.0 3.4362 lateral habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.883909 Embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 anthra(1,9-cd)pyrazol-6(2H)-one CTD Gene-Chemical Interactions 1.0 null abnormal circulating hormone level MPO Gene-Phenotype Associations 1.0 null GSE195568_3_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF605 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18337 Brain Lower Grade Glioma_LGG_TCGA-FG-5962-01B-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34314104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47244 ESRRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0385 BHLHE40 ENCODE Transcription Factor Targets 1.0 null NDUFA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85871 Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.172 pituitary gland tumor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.8322 Lissencephaly 6 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.284 island of Calleja major Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69586 internalization GeneRIF Biological Term Annotations 1.0 null interactions GeneRIF Biological Term Annotations 1.0 null CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.31742 Integumentary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZU-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NAPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75783 neural crest TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.447192 PHF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56336 GSE110178_1_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7582-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210885_0_v_1_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null G protein-coupled receptor activity GO Molecular Function Annotations 2025 1.0 null Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.001 cell property TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.092505 Prostate adenocarcinoma_PRAD_TCGA-EJ-7792-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Interposed nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18639 Serotonergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.764 FGF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45021 Cerebellum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01186 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.95552 g-protein coupled receptor signaling pathway GO Biological Process Annotations 2015 1.0 null BRD-K01225247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26636 BRD-K22537050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3529 BRD-A76899420 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04637 DTX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7974 BRD-K12336887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11921 fasciola cinerea Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46335 metabolic GAD High Level Gene-Disease Associations 1.0 0.313367 Brn3a_KO_GDS1651_248_mouse_Embryonic (day 13.5) trigeminal ganglia - homozygous GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2788-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.99465 ZNF146 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23078 SRP54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21008 SIRT1_KO_GDS4895_410_mouse_brain GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K40892926 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53078 abnormality of the nervous system HPO Gene-Disease Associations 1.0 null CTSZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09184 BRD-K67146164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11088 internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.294223 Non-Functioning Pituitary Gland Neoplasm DisGeNET Gene-Disease Associations 1.0 null Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.365 DSN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56553 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.321 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Poisoning CTD Gene-Disease Associations 1.0 1.08584 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.16604 embryonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.332661 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17634 coarse facial features HPO Gene-Disease Associations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.1315 PCM6 CCLE Cell Line Gene Expression Profiles 1.0 1.41021 SKNFI CCLE Cell Line Gene Expression Profiles 1.0 2.04564 testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.70927 Limbic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.103 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.072 BRD-K14041149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4644 intermediate stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34912 CRCGN017_MCF10A.TP53.M_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33823 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.670996 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05853 H3K27me3_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Seizures CTD Gene-Disease Associations 1.0 1.62335 SCLC21H CCLE Cell Line Gene CNV Profiles 1.0 1.33832 ffm GeneRIF Biological Term Annotations 1.0 null NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.68298 FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 83.1212 CRCGN017_MCF10A.WT.HP_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53455 abnormality of thyroid physiology HPO Gene-Disease Associations 1.0 null intracellular GeneRIF Biological Term Annotations 1.0 null TCF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1418 psych GAD High Level Gene-Disease Associations 1.0 0.293278 arising GeneRIF Biological Term Annotations 1.0 null lateral posterior nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2233 BRD-K83845379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13963 CRCGN009_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 chh1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.616 MEIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9113 Autism DisGeNET Gene-Disease Associations 1.0 null Perturb_12546_KO_Shank2_SRP309197 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.6252 hyperthyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.317545 CRCGN014_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.20667 LYRM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.95925 Dorsomedial nucleus of the hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34222 GSE135350_3_v_5_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null cell surface receptor signaling pathway GO Biological Process Annotations 2015 1.0 null BHLHE41 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8103 BV173 CCLE Cell Line Gene CNV Profiles 1.0 1.60517 TET2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54241 IRS4_KO_GDS1219_306_mouse_brown preadipocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3CE-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.28098 CHEMBL:CHEMBL1451216 DGIdb Drug Targets 2026 1.0 0.444807 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null anterior pretectal nucleus, dorsal superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25254 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.433374 BRD-K25056189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15968 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.917459 intermediate (interpositus) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05943 ZNF536 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21859 Macroglossia DisGeNET Gene-Disease Associations 1.0 null PRR35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4966 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null HD-MY-Z COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 EDARADD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00888 COPS7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49322 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NF-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neurod2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.3482 HDAC2 ENCODE Transcription Factor Targets 1.0 null Hypophysis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN016_MCF10A.TP53.M_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04286 KG1 CCLE Cell Line Gene CNV Profiles 1.0 1.74752 cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06272 mantle zone of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33301 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.49844 KE39 CCLE Cell Line Gene CNV Profiles 1.0 1.52909 grks GeneRIF Biological Term Annotations 1.0 null EFE184 Achilles Cell Line Gene Essentiality Profiles 1.0 1.0 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null congenital hypothyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.813462 Depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.437 Primary motor area, Layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12785 lateral parabrachial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26056 Thyroid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.103 CRCGN014_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.25535 PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-S_YAP_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H2342 COSMIC Cell Line Gene Mutation Profiles 1.0 null Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62145 mantle zone of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21915 BRD-K48717457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32116 CRCGN017_MCF10A.WT.HP_24H:N21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1475 Sensillum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.333 CRCGN010_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.84669 PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK Rummagene Transcription Factor Associations 2026 1.0 null Purkinje cell layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15275 H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE123022,GSE123030_2_v_0_trem2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TAOK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65264 upper basal perifornical nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0238 DPY19L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53082 fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.126597 Hypertrophy CTD Gene-Disease Associations 1.0 1.04538 TAL1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Midbrain, sensory related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61934 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.97407 NCCSTCK140 CCLE Cell Line Gene Expression Profiles -1.0 -1.84916 trafficking GeneRIF Biological Term Annotations 1.0 null CLPX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18843 RNF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37225 Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.183 BRD-K25064302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40933 GSE203181_0_v_1_phosphoramidon_human RummaGEO Drug Perturbation Signatures 1.0 null Dorsomedial nucleus of the hypothalamus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67286 lateral parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.949877 BRD-K88487973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08471 SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1718 GSE110178_5_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null olfactory bulb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.111286 HNRNPLL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24449 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.878666 amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.0817 MEG-01 COSMIC Cell Line Gene Mutation Profiles 1.0 null adinazolam CTD Gene-Chemical Interactions 1.0 null MBLAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56386 ZNF596 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36412 hippocampus (hippocampal formation)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22908 Epilepsy CTD Gene-Disease Associations 1.0 1.08726 TAL1 ENCODE Transcription Factor Targets 1.0 null DNMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85424 mania GWASdb SNP-Phenotype Associations 1.0 0.516504 Lung squamous cell carcinoma_LUSC_TCGA-90-A4EE-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82249895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68831 ZNF304 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74218 CRCGN016_MCF10A.TP53.M_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.96363 FN3K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52334 rat Phosphosite Textmining Biological Term Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2695-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RFC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19114 BRD-K26767874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25507 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09333 TRAF3IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79478 Dopaminergic A13 group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08427 Metencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN015_MCF10A.TP53.M_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2139 ACTR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27473 premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.98752 ZNF668 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.85367 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.61868 lateral geniculate nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.226667 coated pit COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.257289 hsa-miR-4287 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 CRCGN016_MCF10A.TP53.M_24H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20117 Peptide ligand-binding receptors Reactome Pathways 2014 1.0 null Disease of anatomical entity DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 BRD-K37912617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22869 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7048-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PHLPP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.1641 nucleus of the stria terminalis, medial division, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11431 EWS-FLI1-20517297-SK-N-MC-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PBX1-22567123-OVCAR3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null inner CP in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.943666 CRCGN015_HEPG2_48H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.86272 PSIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90579 BRD-K33503286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04525 Paraventricular hypothalamic nucleus, descending division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67764 Liver hepatocellular carcinoma_LIHC_TCGA-LG-A6GG-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933317 BRD-K05657319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45143 ISHIKAWA(HERAKLIO)02ER- COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 CDY2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47719 SNRPB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13258 abnormality of the abdomen HPO Gene-Disease Associations 1.0 null Lateral tuberal nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.846 C2CD4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.44748 HCC1833 CCLE Cell Line Gene Expression Profiles -1.0 -2.64636 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4974-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ectoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.119389 PMC5817105-thnov08p0972s2.xls-SIX3_MTA3-GeneName_SIX3 Rummagene Transcription Factor Associations 2026 1.0 null TIMM17B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88712 PECAPJ34CLONEC12 CCLE Cell Line Gene Expression Profiles 1.0 1.4763 superior frontal gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.41984 MRPL49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16078 endocrine organ benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.555956 r5 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20449 peduncular paraventricular area of PHyA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03974 TC-71 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22906 BRD-K08036779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51915 membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null Breast disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 GTF2H4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38118 GTF2IRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32551 Columnar Cell Hyperplasia Of The Breast DisGeNET Gene-Disease Associations 1.0 null H2BC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38932 behavioral abnormality GWASdb SNP-Phenotype Associations 1.0 0.179203 DGAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49233 abnormal glucose homeostasis MPO Gene-Phenotype Associations 1.0 null ZNF397 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52813 BRD-K79299080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07243 T98G COSMIC Cell Line Gene Mutation Profiles 1.0 null orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15179 Tenia tecta TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.533 CRCGN011_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9884 SCL-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null forebrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.315498 SNU1544 DepMap CRISPR Gene Dependency 1.0 9.64423 primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.961759 pituitary adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.51919 EXTL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01755 Hyperthyroxinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.208 EFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80117 X-linked monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.194 SH3BGRL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52884 BRD-K76588804 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.33402 Substance Withdrawal Syndrome CTD Gene-Disease Associations 1.0 1.30911 signal Phosphosite Textmining Biological Term Annotations 1.0 null CRCGN011_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.74285 DTX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61933 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null CP66-MEL GDSC Cell Line Gene Expression Profiles -1.0 -1.49677 HOXA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59491 amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.883443 cell periphery COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.601066 PMC5338029__F5 PFOCR Pathway Figure Associations 2024 1.0 null external cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83695 lambdoid septal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42403 SLC52A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15578 laterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81093 CRCGN014_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.9062 paraventricular nucleus, cap part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0186 chlordiazepoxide Guide to Pharmacology Chemical Ligands of Receptors 1.0 null PDCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42721 lateral terminal nucleus of the accessory optic tract, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09374 periventricular stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19476 CL14 CCLE Cell Line Gene CNV Profiles -1.0 -1.72043 GSE252864_2_v_3_smad4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lef1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.3053 SNU213 CCLE Cell Line Gene Expression Profiles -1.0 -1.67812 hypothalamic amygdala Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09106 JM1 CCLE Cell Line Gene Expression Profiles 1.0 1.82227 episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06257 CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.32546 integral component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K13627844 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17547 Thyroid cartilage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.51 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 abnormal thyroid hormone level MPO Gene-Phenotype Associations 1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 2.18987 SMAD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6955 PDCD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71534 brain stem TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44015 CHAGOK1 CCLE Cell Line Gene CNV Profiles -1.0 -2.17631 NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.942 BRD-K40474424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07254 BRD-K05753543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01764 Kidney Chromophobe_KICH_TCGA-KO-8403-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Metallochaperone complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.787 abnormality of the head HPO Gene-Disease Associations 1.0 null LARP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12734 BRD-K45315294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.16765 INSM1_Deficiency_GDS5066_272_mouse_Fetal pituitary glands from embryonic day 17.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null polyclonal Phosphosite Textmining Biological Term Annotations 1.0 null Hemispheric regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42311 Growth Delay DisGeNET Gene-Phenotype Associations 1.0 null BRD-K49434474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76122 SIKE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73937 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null CRCGN011_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18985 OSGEP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43253 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2792 TGIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28901 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20P-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPCRs, Class A Rhodopsin-like(Mus musculus) WikiPathways Pathways 2014 1.0 null PKNOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01818 CRCGN010_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.38585 superficial stratum of PCPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09479 amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.41226 BRD-K37564297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50413 CRCGN015_MCF10A_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.422 ZNF652 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1871 SLMAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30909 GIT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20674 Endemic Cretinism DisGeNET Gene-Disease Associations 1.0 null COS-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.422 EPHA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1131 Prostate adenocarcinoma_PRAD_TCGA-G9-7522-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the fontanelles or cranial sutures HPO Gene-Disease Associations 1.0 null medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49965 Acute Myeloid Leukemia_LAML_TCGA-AB-2918-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.2674 diencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.452969 Dyssomnias DisGeNET Gene-Disease Associations 1.0 null CRCGN014_HEPG2_3H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.85513 A-VN-1203-2004(H5N1)_Day7-10^3pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.9446 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5369-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Organism form TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 AMO1 DepMap CRISPR Gene Dependency 1.0 2.82787 TUFM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14783 MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null midbrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.116901 GSE179002_2_v_6_caprin1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SLC7A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24957 GSE120612_7_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K20098898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63582 PRRX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0768 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37442 DU4475 DepMap CRISPR Gene Dependency 1.0 3.90967 cell part LOCATE Predicted Protein Localization Annotations 1.0 null DBNDD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78191 USP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05165 muscular atrophy GWASdb SNP-Disease Associations 1.0 1.53704 LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.883977 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43S-01A-21R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A3LQ-01A-21R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63315 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3017 G alpha (q) signalling events Reactome Pathways 2014 1.0 null TAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84805 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10204 spanning component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.852042 plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PHF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92983 intermediate stratum of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16548 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04521 cardiovascular GAD High Level Gene-Disease Associations 1.0 0.293278 IP6K1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20934 PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR Rummagene Transcription Factor Associations 2026 1.0 null DUSP28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48641 Thyroid cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K80210288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32891 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7841-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Basomedial amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34433 HCT116 DepMap CRISPR Gene Dependency 1.0 3.77168 endocytic vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.203022 thyroid gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.14136 Medial geniculate nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.54 BRD-A93436351 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8991 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.433 cos-7 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.465335 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q5-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null increased oxygen consumption MGI Mouse Phenotype Associations 2023 1.0 null SK-MES-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null medial amygdala, anteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14066 cell part GO Cellular Component Annotations 2015 1.0 null Gender incongruence DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.053 Neurosecretory cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.62 EIF3M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48352 AML193 DepMap CRISPR Gene Dependency 1.0 3.68626 BRD-K89263606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01008 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.857414 intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.286245 nerve TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062673 KDM4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7052 Retinal ganglion cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.495 BRD-K61087440 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07189 Nectar TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.638 BRD-A80081229 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10642 CRCGN008_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.5229 ZBTB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48334 immunology Phosphosite Textmining Biological Term Annotations 1.0 null RS11846 BioGPS Cell Line Gene Expression Profiles 1.0 0.944471 A_CA_04_2009_4dayMOI-10^4_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.64348 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.11624 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AE-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5508 abnormality of the musculature HPO Gene-Disease Associations 1.0 null KMS26 DepMap CRISPR Gene Dependency 1.0 5.31957 BRD-K60188503 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02205 Medial amygdalar nucleus, anteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68566 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040829 cos-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.11553 amygdalohippocampal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01616 amygdala TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.237513 MED24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95572 cytoplasmic vesicle LOCATE Curated Protein Localization Annotations 1.0 null LTF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28735 periventricular stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11526 BRD-A63759745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60304 Congenital nongoitrous hypothyroidism 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.218 Medial amygdalar nucleus, posterodorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.68518 superficial stratum of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46335 Anxiety disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.013 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6010-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null placenta TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 cortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.868511 phospholipase C-activating G protein-coupled receptor signaling pathway GO Biological Process Annotations 2025 1.0 null MDAMB361 DepMap CRISPR Gene Dependency 1.0 2.6015 BRD-K51431550 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.68991 Triazolam CTD Gene-Chemical Interactions 1.0 null Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22227 BRD-K14799424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35686 salicyl-alcohol LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.11301 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null decreased circulating pituitary hormone level MPO Gene-Phenotype Associations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null after GeneRIF Biological Term Annotations 1.0 null BRD-K22229373 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.75223 periventricular stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20449 DCAF4L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73178 NCI-H1568 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN014_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15667 Lateral mammillary nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.835 CRCGN017_MCF10A.WT.HP_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7251 BRD-K33986892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92891 zona incerta TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.341495 Internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22906 NCI-H1944 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06293 AKT1_knockdown_141_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.3832 Pituitary gonadotropin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.554 Nthy-ori 3-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.555 ventrolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.95661 trhr GeneRIF Biological Term Annotations 1.0 null Dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21481 hyperaldosteronism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.362978 GSE210885_5_v_6_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null hindbrain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.85516 Inflammation CTD Gene-Disease Associations 1.0 1.31 GSE99687_2_v_1_smad5_human RummaGEO Gene Perturbation Signatures 1.0 null behavioral despair MPO Gene-Phenotype Associations 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.66468 CI-1040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2213 RIPOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01402 HCC2998 BioGPS Cell Line Gene Expression Profiles 1.0 1.3739 BRD-A84913188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1221 ovary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.3163 membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.286245 Heterotrimeric G-protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.24 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03851 BRD-K72135530 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.53656 abdominal wall defect HPO Gene-Disease Associations 1.0 null SLR20 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.03384 lateral portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20819 intermediate stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09594 Tachycardia_Myocardial tissue_GSE7999 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.27101 ZNF419 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47005 bone remodeling disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.670996 intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null adenoma GeneRIF Biological Term Annotations 1.0 null BRD-K43390655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37401 Flurazepam CTD Gene-Chemical Interactions 1.0 null superficial stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10255 GPCR ligand binding Reactome Pathways 2014 1.0 null VEGFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47288 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.462398 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AU-01A-32R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Semaphorin receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.561 15902281-TableS1a GeneSigDB Published Gene Signatures 1.0 null cuneus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.850063 superficial stratum of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38948 CV-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.299 basal peduncular hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06237 MDAMB436 CCLE Cell Line Gene CNV Profiles -1.0 -1.45947 Peptide GPCRs WikiPathways Pathways 2024 1.0 null CRCGN017_MCF10A.WT.HP_24H:P09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3027 MLX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6061 LUC7L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39472 COV318 CCLE Cell Line Gene CNV Profiles -1.0 -2.0545 NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03851 MAPK1_knockdown_145_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.31213 SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.9693 Perturb_3514_KD_RNPS1_ERP130704 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.10689 SERPINB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98646 CKAP2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28762 all HPO Gene-Disease Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PANC0327 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.14518 hair TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.106536 Testis BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.925255 SOCS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.561 NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55429 CCDC103 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5438 MORC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69927 KS-IMM cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.589 thyrotropin-releasing hormone receptor activity GO Molecular Function Annotations 2015 1.0 null HO-1-U-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 Lung squamous cell carcinoma_LUSC_TCGA-43-6143-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null subpallial amygdala Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12487 CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.63237 GABA-A receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.019 IGROV1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.32278 g-protein coupled receptor activity GO Molecular Function Annotations 2015 1.0 null Thyroid follicular epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.344 Prostate adenocarcinoma_PRAD_TCGA-YL-A8HJ-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATG101 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4967 CHFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35015 SORBS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26973 CRCGN017_MCF10A.WT.HP_24H:P10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0185 KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K50191826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29417 posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14788 CRCGN014_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.3749 Basolateral amygdalar nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06869 GRHL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63941 ZNF549 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22694 CSRNP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97996 GSE137954_4_v_2_smyd3_mouse RummaGEO Gene Perturbation Signatures 1.0 null lower dorsal lateral hypothalamic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06282 Prostate adenocarcinoma_PRAD_TCGA-J4-A83J-11A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null constipation HPO Gene-Disease Associations 1.0 null cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 membrane LOCATE Predicted Protein Localization Annotations 1.0 null cos cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.991944 inner SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.48872 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K08629159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03228 DHRS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02173 DDX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05515 AP1S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20651 diazepam Guide to Pharmacology Chemical Ligands of Receptors 1.0 null abnormal fear/anxiety-related behavior MPO Gene-Phenotype Associations 1.0 null GRHL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18191 phosphatases GeneRIF Biological Term Annotations 1.0 null ML1 CCLE Cell Line Gene Expression Profiles -1.0 -1.45514 PMPCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49946 mantle zone of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16377 PMC7671546__F8 PFOCR Pathway Figure Associations 2023 1.0 null FOSL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5535 NDUFB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80207 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A6UG-01A-32R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201042_6_v_0_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null decreased body weight MGI Mouse Phenotype Associations 2023 1.0 null GPCRs, Class A Rhodopsin-like(Homo sapiens) WikiPathways Pathways 2014 1.0 null Euthyroid sick syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.263 pretectal region Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.954213 BRD-K36324810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19332 L-type voltage-gated calcium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.515 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54F-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_2163_KD_Chd8_SRP062904 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.2141 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.40064 CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69889 BRD-K98790311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04901 pineal gland Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.960166 germ layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.077344 cos-cells Phosphosite Textmining Biological Term Annotations 1.0 null Extraocular muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.732 into GeneRIF Biological Term Annotations 1.0 null GSE69244_1_v_0_j147_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z3-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4634-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null signal transduction GO Biological Process Annotations 2015 1.0 null laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.89532 GSE171352_2_v_3_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.WT.HP_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4187 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14352 Posterior lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.018 SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07595 OS9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06578 mantle zone of PcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15761 Global Developmental Delay DisGeNET Gene-Disease Associations 1.0 null TBC1D4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26818 AZETIRELIN DGIdb Drug Targets 2026 1.0 7.56171 RPL14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73105 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.927204 NCIH510 CCLE Cell Line Gene CNV Profiles 1.0 2.33042 almost GeneRIF Biological Term Annotations 1.0 null GSE226452_1_v_2_imiquimod_mouse RummaGEO Drug Perturbation Signatures 1.0 null Attention deficit hyperactivity disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 TAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07957 shell of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03755 layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.856689 BRD-K29609299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.4167 PMC11876052-DataSheet2.xlsx-Endo2-GATA3_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null hormone Phosphosite Textmining Biological Term Annotations 1.0 null increased anxiety-related response MPO Gene-Phenotype Associations 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 abnormality of the oral cavity HPO Gene-Disease Associations 1.0 null BRD-K51572611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23262 PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S6-Synteny-Syntenic_Analysis_for_29_HSF1-CanSig_8q_Genes_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.843843 Hyperpituitarism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.463 CAPN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52555 HTRA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64328 DPRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.58998 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52416 osteoblasts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.34822 decreased circulating thyroxine level MPO Gene-Phenotype Associations 1.0 null PPARGC1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55353 Adrenal gland hyperfunction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.49088 BRD-K88802328 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63438 GSE102870_3_v_9_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55489 BRD-K86192746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99945 MTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64004 vesicle LOCATE Curated Protein Localization Annotations 1.0 null anthraquinone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31536 Leydig cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.14 medial amygdala, posterodorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.73323 BRD-K44218044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08573 adrenal gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.103348 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FF-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null COLO-741 GDSC Cell Line Gene Expression Profiles -1.0 -1.60421 Learning Disorders CTD Gene-Disease Associations 1.0 2.05445 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.377 nthy-ori 3-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.934911 VWA5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81596 DUSP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02006 PMC5655367__F4 PFOCR Pathway Figure Associations 2024 1.0 null EKC/KEOPS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.607 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2295 LRRC10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3625 Lung squamous cell carcinoma_LUSC_TCGA-77-A5GH-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.87883 GDI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50421 CRCGN012_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6914 primary motor-sensory cortex (samples)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12382 CRCGN017_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.3693 abnormality of immune serum protein physiology GWASdb SNP-Phenotype Associations 1.0 0.646367 periventricular stratum of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09419 GPR150 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60993 Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23989 Serotonin receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.158 hernia HPO Gene-Disease Associations 1.0 null ventral posterior medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04631 GSE128076_1_v_3_doxycycline_human RummaGEO Drug Perturbation Signatures 1.0 null SETDB1_KO_GSE40296_7_mouse_brain (telencephalon) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ABCF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32632 telencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069383 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.95552 sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.192248 White Blood Cell Count Procedure DisGeNET Gene-Phenotype Associations 1.0 null NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3821 EB-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.01332 4-P-PDOT LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39069 organism form TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null variation GeneRIF Biological Term Annotations 1.0 null ERI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15483 AP-4 MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K06611347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05809 integral component of membrane GO Cellular Component Annotations 2015 1.0 null hypertension GAD Gene-Disease Associations 1.0 null BRD-K62462045 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05081 Grm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.01 Midazolam CTD Gene-Chemical Interactions 1.0 null H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2 ENCODE Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QQ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDC5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63376 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30396 pituitary gland tumor cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 2.01932 Status Epilepticus CTD Gene-Disease Associations 1.0 1.33052 Horizontal cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.756 EWSR1 ChEA Transcription Factor Targets 1.0 null tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.837449 BRD-K09598619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34093 CRCGN015_MCF10A.WT.HP_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.8712 CRCGN008_HEPG2_24H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.09855 TLE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9643 BRD-K22668106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00773 Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055451 H2AC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41174 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34713 CRCGN016_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.55528 body mass (lean) GAD Gene-Disease Associations 1.0 null intermediate stratum of PSPa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27222 abnormality of the abdominal organs HPO Gene-Disease Associations 1.0 null Perturb_7505_OE_ADARB1/ILF3_SRP195616 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.77482 Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6135-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K44622259 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67737 ELF5-23300383-T47D-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SRGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67528 496100383_HIP_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0576 LYPLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71534 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.829776 ZNF708 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64904 disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040452 EXO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.79295 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.62019 HTT-18923047-STHDH-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 15888489-Table1 GeneSigDB Published Gene Signatures 1.0 null Endopeduncular nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.995 Kidney Chromophobe_KICH_TCGA-KO-8413-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.549709 m15 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.647 Thoracic cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null supramarginal gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.983386 VCY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58646 Bamforth-Lazarus syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.123 Mesothelioma_MESO_TCGA-SC-A6LQ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Midbrain central gray TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.015 NCIH211 CCLE Cell Line Gene CNV Profiles 1.0 1.9291 Ebolavirus(ZEBOV)_6day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.071869 Dopaminergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.608 BRD-K37544873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76466 ZNF292 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28047 GSE89057_0_v_1_sox5_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05341 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K19168437 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46228 PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4ND-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4685-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 Medial amygdalar nucleus, posterodorsal part, sublayer b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.37033 NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51656 Body mass (lean) GWAS Catalog SNP-Phenotype Associations 1.0 0.552116 BRD-K00502422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28843 MRPS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83496 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.880817 SEMA3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52763 RL95-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null SNU81 DepMap CRISPR Gene Dependency 1.0 3.38886 Thyroid epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.675 EW-1 GDSC Cell Line Gene Expression Profiles 1.0 1.6288 Drug-Related Side Effects and Adverse Reactions CTD Gene-Disease Associations 1.0 1.09262 primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06814 ZR7530 CCLE Cell Line Gene CNV Profiles 1.0 2.61698 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPK15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6444 Infundibular nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.951 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null Perturb_2697_KO_ADIPOR1_SRP089784 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.401 posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.857947 INO80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02775 POLR2AphosphoS5_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31757099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.99603 Synucleinopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.074 CRCGN013_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8574 DNAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94596 pituitary gland cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 2.01505 superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05943 Breast carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 CRCGN011_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.82405 Endocrine organ benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.581 Adenohypophysis tumor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.812 HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null DPM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37568 cellular_component GO Cellular Component Annotations 2015 1.0 null superficial stratum of PSPa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2048 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.866822 BRD-K10221669 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36204 follicle-stimulating hormone complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.906 Lean Body Mass DisGeNET Gene-Phenotype Associations 1.0 null DISP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52616 PIK3R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81819 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064622 abnormal emotion/affect behavior MPO Gene-Phenotype Associations 1.0 null TSPYL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42604 DCPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50074 CRTC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49378 SLC27A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83132 NPAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21727 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Reactome Pathways 2014 1.0 null 2,4,5,2',4',5'-hexachlorobiphenyl CTD Gene-Chemical Interactions 1.0 null striatum_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.860533 MITF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3554 periventricular stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27784 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16329 TIG3TD CCLE Cell Line Gene Expression Profiles -1.0 -1.81718 sequences GeneRIF Biological Term Annotations 1.0 null Cornu ammonis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.032 RALB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53796 Umbilical hernia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.364 HDHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20963 Lateral dorsal nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.839 Pars distalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.876 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null paraventricular nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00401 BRD-K78886448 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0513 orbital frontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28842 Cerebral peduncle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.805 bone remodeling disease GWASdb SNP-Disease Associations 1.0 0.516381 OE19 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 Hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.255 Hypertension CTD Gene-Disease Associations 1.0 1.28364 GSE219154_4_v_2_aspirin_human RummaGEO Drug Perturbation Signatures 1.0 null BLTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17486 OSBPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33498 TAL1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37132 hek-293 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.659085 BRD-K07697589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4079 SCLY ChEA Transcription Factor Targets 1.0 null mood disorder GWASdb SNP-Disease Associations 1.0 0.438563 MAGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.67604 neuroactive ligand receptor interaction KEGG Pathways 1.0 null cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24079 Cortical amygdalar area, posterior part, medial zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42403 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.64223 BRD-K95409124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.21312 intermediate stratum of the VAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49331 LP1 CCLE Cell Line Gene Expression Profiles 1.0 1.78048 CKM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.198 Secondary motor area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17634 Organ system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 primary motor cortex (area M1, area 4)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.902857 GPCRs class A rhodopsin like WikiPathways Pathways 2024 1.0 null MYBPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83288 KYSE-50 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 COG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93575 BHLHE40_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K97617600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27445 SKP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53702 496100597_HIP_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0518 SubthalamicNucleus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.866945 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051021 BRD-K41729242 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01474 NOTO JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6908 HMGCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62507 BRD-K17239874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03359 KIF5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84455 amygdaloid complex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.57048 CAVIN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13457 LBR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60558 osteoporosis DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.670996 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A0TN-01A-21R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K66539236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24768 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38142 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68F-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Daytime sleep phenotypes GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.569897 cell projection part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045534 BRD-K07456098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02005 Cerebellar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38122 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30688 BRD-K24164383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34807 CRCGN015_MCF10A.TP53.M_24H:J07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1106 septostriatal transition area (accumbens) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21811 MYB-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hypertension; obesity GAD Gene-Disease Associations 1.0 null GJB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0433 DAGLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64452 CDK8_knockdown_147_GSE32108 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.01911 CRCGN015_HEPG2_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.06501 Ventromedial hypothalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.874 OIP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17955 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 DBTRG05MG Achilles Cell Line Gene Essentiality Profiles -1.0 -1.1573 GSE102870_3_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K50479239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2763 USP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28017 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null GSE130437_2_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4620-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LNZTA3WT4 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5769-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01092 CRCGN014_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.62207 ABCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2641 Thalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.697 CRCGN014_HEPG2_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91332 HUH-6-CLONE5 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN009_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.65348 HCC1143 CCLE Cell Line Gene CNV Profiles 1.0 2.03602 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:A21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61205 SF539 BioGPS Cell Line Gene Expression Profiles 1.0 1.0015 CRCGN014_HEPG2_3H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.2155 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.339 PCNA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42042 Posterior amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.36129 Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.428 TMEM161A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81045 P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 2.02575 neural crest cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.1483 PMC3077393__F8 PFOCR Pathway Figure Associations 2023 1.0 null BL70 CCLE Cell Line Gene Expression Profiles 1.0 1.57676 NUP210 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06454 CRCGN014_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.29773 cell part LOCATE Curated Protein Localization Annotations 1.0 null Disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 PMC11801220-NIHMS2038999-supplement-16.xlsx-Exc-BNC2-gene_BNC2 Rummagene Transcription Factor Associations 2026 1.0 null Stria terminalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.118 FBXO31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.64321 TIPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45584 TRAPPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99229 neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073237 epitope Phosphosite Textmining Biological Term Annotations 1.0 null ST8SIA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43885 DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4815-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.2581 POLR1H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22536 VSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.614 Liver hepatocellular carcinoma_LIHC_TCGA-CC-5258-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K25330450 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5576 grl101 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.845 optic fiber layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36796 Habenula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.974 HEC1A Achilles Cell Line Gene Essentiality Profiles -1.0 -1.74891 KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85772 APLP2_KO_GDS4414_371_mouse_prefrontal cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null spinal trigeminal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.838155 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PATU8988T CCLE Cell Line Gene Expression Profiles -1.0 -1.70667 INSM1_lack of the seven N-terminal amino acids_GDS5066_404_mouse_pituitary glands GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K30865566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04406 Hair shaft TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.731 WDR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12395 decreased circulating gonadotropin level MPO Gene-Phenotype Associations 1.0 null GSE81803,GSE81912_0_v_1_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Occipital lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.212 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.272 UROS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81978 Striatum-like amygdalar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16649 CRCGN014_HEPG2_3H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67482 496100521_HIP_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.27306 RABGGTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19963 REPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65866 PMC6791490__F3 PFOCR Pathway Figure Associations 2023 1.0 null female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.563238 Mental Disorders HuGE Navigator Gene-Phenotype Associations 1.0 null E2F7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2724 BFTC-905 GDSC Cell Line Gene Expression Profiles -1.0 -1.55721 ZNF776 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73514 SMNDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21312 Psychomotor Disorders CTD Gene-Disease Associations 1.0 1.19312 BRD-K61886116 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04437 paraventricular nucleus, peduncular or principal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09373 MAP1LC3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64058 GSE178714_5_v_7_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null BACH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.73096 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Septooptic dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.429 CUL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4263 Ataxia CTD Gene-Disease Associations 1.0 1.34811 BRD-A95683194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2312 BRD-K18245187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2979 cingulate gyrus, retrosplenial part, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.897044 acromegaly DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.856087 MCF7 CCLE Cell Line Gene CNV Profiles 1.0 1.61685 BRD-K71221636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42855 PLA2G4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16955 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.996286 CRCGN008_HEPG2_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.29595 CHD1 ENCODE Transcription Factor Targets 1.0 null 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.43622 CRCGN017_MCF10A.TP53.M_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.19829 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.75146 layer 3 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28651 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.953494 MAGEH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96011 SK-MES-1 GDSC Cell Line Gene Expression Profiles 1.0 2.39901 LCOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73 membrane GO Cellular Component Annotations 2015 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CM-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RANBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07114 Paramedian lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22405 CLC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17059 GSE183994_1_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MTX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98264 leydig cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.704355 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.954838 PTPRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71286 CRCGN016_MCF10A.TP53.M_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.16855 SPIN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85661 U266B1 CCLE Cell Line Gene Expression Profiles 1.0 2.45312 MZ in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11345 G protein-coupled receptor activity GO Molecular Function Annotations 2023 1.0 null Neonatal jaundice DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.34 BRD-K66061243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89096 CRCGN015_MCF10A.TP53.M_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1127 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 9.1726 CRCGN017_MCF10A.WT.HP_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.55135 PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.912663 decreased triiodothyronine level MGI Mouse Phenotype Associations 2023 1.0 null BRD-K36464765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50601 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.840115 anterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01573 FOXP2 ChEA Transcription Factor Targets 1.0 null CRCGN013_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.49111 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80M-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055938 RVH-421 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K23666684 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03238 Bhlha15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.0824 CRCGN014_HEPG2_24H:J15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.92945 RIMS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39453 CRCGN015_HEPG2_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.60403 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3316-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM120A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04925 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55636 CH157MN Achilles Cell Line Gene Essentiality Profiles -1.0 -1.93808 HLE COSMIC Cell Line Gene Mutation Profiles 1.0 null BHLHE40 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6647 DIRAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30832 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4329-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.91006 Distal dendrite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.099 superficial stratum of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2567 BICR18 CCLE Cell Line Gene Expression Profiles 1.0 1.58996 Paramedian lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0615 BRD-K66311249 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.1476 496100417_HIP_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.77707 HBS1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67484 cerebral hemisphere TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066884 Basal forebrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.975 NO11 DepMap CRISPR Gene Dependency 1.0 2.13972 Primary motor area, Layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46335 CRCGN012_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.13765 aplasia/hypoplasia of the abdominal wall musculature HPO Gene-Disease Associations 1.0 null 496100604_HIP_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.64144 CRTC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42581 Bradycardia CTD Gene-Disease Associations 1.0 1.26113 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6R0-01A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K38244121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40562 abnormal emotion/affect behavior GWASdb SNP-Phenotype Associations 1.0 0.376579 FOXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04156 adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.911433 CRCGN015_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0538 OPM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.67931 Calcium signaling pathway KEGG Pathways 2026 1.0 null CENPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05055 Prostate adenocarcinoma_PRAD_TCGA-HC-A76W-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89167 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.862638 GSE102132_2_v_1_irf3_human RummaGEO Gene Perturbation Signatures -1.0 null MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0766 connective tissue disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.008116 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.512564 GSE213228_4_v_5_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.3018 dorsal part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11056 SEMA3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38796 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null SUMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43279 CRCGN015_HEPG2_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.24662 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4615 BRD-K07781811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.78101 endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.063916 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GT-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 4 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10053 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05769 decreased circulating prolactin level MGI Mouse Phenotype Associations 2023 1.0 null Stat6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.5205 CRCGN014_HEPG2_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.626 Large Posterior Fontanelle DisGeNET Gene-Phenotype Associations 1.0 null GSE196199_0_v_1_zbtb20_mouse RummaGEO Gene Perturbation Signatures 1.0 null PNKD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53877 PTDSS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86849 thyrotropinreleasing GeneRIF Biological Term Annotations 1.0 null COLO-792 COSMIC Cell Line Gene Mutation Profiles 1.0 null TEFM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40403 GRB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63242 either GeneRIF Biological Term Annotations 1.0 null fetus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null intrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.140441 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.5865 Usp22_DEPLETION_GDS4973_284_mouse_E14 embryonic stem cells (ESCs) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JI-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46514 Medial septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1176 GSE171292_5_v_2_ehhadh_mouse RummaGEO Gene Perturbation Signatures 1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.163 TMEM106A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18725 disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.670996 TAF1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24694 rats-sprague-dawley Phosphosite Textmining Biological Term Annotations 1.0 null Pulvinar TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.794 GSE215461_0_v_1_topotecan_human RummaGEO Drug Perturbation Signatures -1.0 null G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14074 RHOH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19432 Physical disorder DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 EKVX BioGPS Cell Line Gene Expression Profiles -1.0 -1.44921 PBX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29535 posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.861359 PK45H DepMap CRISPR Gene Dependency 1.0 2.3023 BRD-K80073743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17327 striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.966351 nerve-tissue-proteins Phosphosite Textmining Biological Term Annotations 1.0 null Pierpont syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.262 Perturb_8949_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.3197 Copula pyramidis, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00076 H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3226 Biceps brachii TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.034 496100319_HIP_no dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.63098 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.04591 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18069 Preoptic area TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.361 conn's syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.299812 diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6332-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hyperkinesis CTD Gene-Disease Associations 1.0 1.17695 GSE126345_2_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null gh1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.772 abnormality of the skull HPO Gene-Disease Associations 1.0 null Dentate granule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.867 Lung squamous cell carcinoma_LUSC_TCGA-58-A46L-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Graves' disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.316 PMC9689226__F8 PFOCR Pathway Figure Associations 2024 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5761-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenalgland BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.908403 L3MBTL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72269 Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 Psoriasis vulgaris_Skin tissue_GSE14905 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.7851 Parastrial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28843 CFAP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65209 KP4 CCLE Cell Line Gene CNV Profiles 1.0 2.23111 Lateral geniculate nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.769 P2RX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05014 BRD-K57938735 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31449 SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18647 H3K27me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Subthalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35879 MEF2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71949 myopathy GWASdb SNP-Disease Associations 1.0 0.37196 t52-hippocampus_consensus MoTrPAC Rat Endurance Exercise Training 1.0 3.69994 Sheehan syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.307 EOMES JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7735 CRCGN014_HEPG2_3H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0172 MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.8714 A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_2day-MOI-10^4_None_GSE43301 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.52178 organelle LOCATE Curated Protein Localization Annotations 1.0 null RPS9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23608 signaling receptor activity GO Molecular Function Annotations 2015 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tadpole TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.934 primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23167 HCC1428 CCLE Cell Line Gene CNV Profiles 1.0 1.75257 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3326-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null supporting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.187698 ZNF559 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45866 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.95552 monomeric Phosphosite Textmining Biological Term Annotations 1.0 null BCL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77914 BRD-K86143816 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52451 Prostate adenocarcinoma_PRAD_TCGA-EJ-7330-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PNMA8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64262 HUO-3N1 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 Pituitary gland cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.369 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34372 GOLGA6L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48429 SMARCD1-25818293-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null dorsal part of PcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15634 NCIH446 CCLE Cell Line Gene CNV Profiles 1.0 3.02478 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8005-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZDHHC20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13924 Anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08043 cho-cells Phosphosite Textmining Biological Term Annotations 1.0 null posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.857039 TAL1-21186366-BM-HSCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.811 Tauopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.266 Cortical amygdalar area, posterior part, lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4582 ARHGEF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38866 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47005 Posterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52338 Nodulus (X) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57741 Zfp335 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.631 GSE178532_1_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K75745696 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08424 BRD-A82843133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.10715 plasma membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 CENPW CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82464 BRD-K36909552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47187 RAB3GAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08501 connective tissue disease GWASdb SNP-Disease Associations 1.0 0.195968 core of nucleus accumbens Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.912418 MCRIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31524 C2orf81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11998 BRD-K97733472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20355 superficial stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25254 GSE218580_1_v_0_fentanyl_mouse RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-3187-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 spinalcordupper BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.28412 NELFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.18391 SNU601 CCLE Cell Line Gene Expression Profiles -1.0 -1.64564 BRD-K96764878 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96928 CRCGN015_HEPG2_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.6037 BAG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81439 NCOA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8971 ADAM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08641 SNU-C1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85772 LCN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07215 BRD-K84090286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90546 BRD-K33710385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14627 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K19752998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05279 Hallucinations CTD Gene-Disease Associations 1.0 1.45989 RPL13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80865 A204 GDSC Cell Line Gene Expression Profiles 1.0 1.46697 CRCGN011_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0045 UBE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41699 HDGF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94557 Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23759 BRD-K26127374 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04092 periventricular stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22071 cognate GeneRIF Biological Term Annotations 1.0 null bipolar disorder GWASdb SNP-Disease Associations 1.0 0.608124 arrestins Phosphosite Textmining Biological Term Annotations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A181-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Slit-Robo signaling complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.502 cognitive impairment GWASdb SNP-Phenotype Associations 1.0 0.572823 cerebellar nuclei of CbV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24853 mental depression GWASdb SNP-Disease Associations 1.0 0.778649 Parabrachial nucleus, lateral division, ventral lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00706 Neuron projection branch point COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.646 BRD-K21215763 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41243 Pars intermedia TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.528 MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.1642 disease GWASdb SNP-Disease Associations 1.0 0.047526 abnormality of the mouth HPO Gene-Disease Associations 1.0 null TNFRSF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14386 Acute Myeloid Leukemia_LAML_TCGA-AB-2882-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Constipation DisGeNET Gene-Phenotype Associations 1.0 null MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03851 BRD-A55025683 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80807 RFXANK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37208 GRIN2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17118 CRCGN011_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8048 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null Median eminence TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.28 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.53069 ARAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21914 BRD-K10189430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86197 BRD-K01787291 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17502 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.764 Specific developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.56 hypothalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.455284 Secondary Hypothyroidism DisGeNET Gene-Disease Associations 1.0 null Cortical amygdalar area, posterior part, medial zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89125 MYLIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11552 calcium signaling pathway KEGG Pathways 1.0 null CCDC47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51813 deep layers of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39765 CRCGN017_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.8018 CRCGN015_HEPG2_48H:D17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.192 CRCGN015_HEPG2_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.72564 superficial stratum of AHy Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09259 NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85772 Superior colliculus, zonal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12278 SNU869 CCLE Cell Line Gene Expression Profiles 1.0 2.00759 CRCGN009_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0695 layer 1 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48375 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.867071 CRCGN015_HEPG2_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.65831 AIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9415 FUT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05464 MM127 DepMap CRISPR Gene Dependency 1.0 2.47011 Frontal pole, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06468 Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.3333 DEL COSMIC Cell Line Gene Mutation Profiles 1.0 null ACBD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7175 Body mass (lean) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.939794 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN017_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0285 medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15129 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.925255 hernia of the abdominal wall HPO Gene-Disease Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7738-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K00676343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73355 CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.99024 LN215 CCLE Cell Line Gene Expression Profiles -1.0 -1.47958 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6N0-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE230263,GSE230265_3_v_1_runx1_human RummaGEO Gene Perturbation Signatures 1.0 null TRH Pathway Commons Protein-Protein Interactions 1.0 null ZNF793 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27345 Mesothelioma_MESO_TCGA-MQ-A4LV-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C2CD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42816 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PA-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 647-V GDSC Cell Line Gene Expression Profiles -1.0 -2.67891 Rectum adenocarcinoma_READ_TCGA-CI-6624-01C-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PF-382 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07723 DYNC1I2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74363 Medial amygdalar nucleus, posterodorsal part, sublayer a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.62328 abnormal hormone level MPO Gene-Phenotype Associations 1.0 null ZSWIM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46811 inferior occipital gyrus, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.858807 clidinium LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84954 BRD-K27584103 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08829 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2017 superior parietal lobule, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03989 Sleep Disturbances DisGeNET Gene-Phenotype Associations 1.0 null HL60 BioGPS Cell Line Gene Expression Profiles -1.0 -1.6551 Brain Lower Grade Glioma_LGG_TCGA-DU-6393-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPM1G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89321 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.882292 posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.33152 GSE171292_1_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-8126-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.866348 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.90402 CTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60521 184B5 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.643115 CRCGN015_HEPG2_48H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6109 adrenal cortex disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.11833 HCC44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933317 interior GeneRIF Biological Term Annotations 1.0 null BRD-K54042694 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32136 GSE130401_4_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null E2F8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97546 cortico-medial group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.70101 CRCGN009_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 BRD-K14392329 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1462 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20W-01A-21R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25397 SARC9371 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_8942_KO_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null CRCGN016_MCF10A.TP53.M_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.05024 Thyrotropin-releasing hormone resistance, generalized ClinVar Gene-Phenotype Associations 1.0 null 19893992-Table1 GeneSigDB Published Gene Signatures 1.0 null Fetalbrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.925255 Chiasma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.904 CUL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04219 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5440-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17309 thyrotropin-releasing hormone receptor activity GO Molecular Function Annotations 2025 1.0 null CRCGN012_HEPG2_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.30422 BCDIN3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.19887 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.04677 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17293 Night sleep phenotypes GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.530103 SCL-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null DIMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88683 IFIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15877 SEC24C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15747 CRCGN014_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8225 periventricular stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10279 BRD-K16605233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02822 Class A/1 (Rhodopsin-like receptors) Reactome Pathways 2014 1.0 null GPCR ligand binding Reactome Pathways 2024 1.0 null LN235 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.43352 CRCGN017_MCF10A.WT.HP_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.8553 Parasubthalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10723 GABA-ergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.148 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MP-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary hyperaldosteronism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 BRD-K86529788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07058 FIS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37895 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.81689 TM9SF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84777 Thyroid gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.34 benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.772887 CRCGN015_HEPG2_48H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.74598 BRD-A82394575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40725 OCIAML5 Achilles Cell Line Gene Essentiality Profiles 1.0 1.03847 receptor activity GO Molecular Function Annotations 2015 1.0 null H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_HEPG2_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.09426 abnormality of the skeletal system HPO Gene-Disease Associations 1.0 null BRD-K80066561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01728 signal GeneRIF Biological Term Annotations 1.0 null AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null SLC5A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68375 ZBTB18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86659 Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.031 Hypothermia CTD Gene-Disease Associations 1.0 1.13007 thyrotropin-releasing hormone receptor activity GO Molecular Function Annotations 2023 1.0 null Nodulus (X), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30424 abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.087809 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 musculoskeletal system disease GWASdb SNP-Disease Associations 1.0 0.245187 Composite lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 COMTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34965 TCF4 ChEA Transcription Factor Targets 1.0 null Myoclonus CTD Gene-Disease Associations 1.0 1.07163 GSE171179,GSE171181_0_v_1_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null cytoplasmic membrane-bounded vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049739 Proximal dendrite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.885 CYB5R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39232 isoproterenol Phosphosite Textmining Biological Term Annotations 1.0 null NRARP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08754 Anxiety Disorders CTD Gene-Disease Associations 1.0 1.59943 CRCGN014_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9957 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06006 abnormality of the abdominal musculature HPO Gene-Disease Associations 1.0 null 496100487_HIP_probable Alzheimer's disease_no TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.74567 MLXIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42841 BRD-K97170716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57004 HCE-4 GDSC Cell Line Gene Expression Profiles 1.0 1.61993 internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN015_HEPG2_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.69185 CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.2301 LC1SQSF CCLE Cell Line Gene Expression Profiles 1.0 1.37348 BRD-K89524688 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26461 HIKESHI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24025 several psychiatric disorders GAD Gene-Disease Associations 1.0 null GCIY CCLE Cell Line Gene Expression Profiles -1.0 -1.54288 BRD-K19766710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56755 OCIMY5 CCLE Cell Line Gene CNV Profiles -1.0 -2.02751 SNU216 CCLE Cell Line Gene CNV Profiles 1.0 1.50553 TMED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05053 PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-e-Classification_of_camel_SON_basal_genes_-_G_protein_coupled_receptors_SON Rummagene Transcription Factor Associations 2026 1.0 null SMAD4 ChEA Transcription Factor Targets 1.0 null A375 GDSC Cell Line Gene Expression Profiles 1.0 1.56328 496100392_HIP_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.73644 Prolonged Neonatal Jaundice DisGeNET Gene-Phenotype Associations 1.0 null X-linked recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.207 Raphe nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.141 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16635 Ovarian cyst TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.691 DYNC2I1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55305 GSE86507,GSE86509_4_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null RERFLCAD2 DepMap CRISPR Gene Dependency 1.0 2.95021 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.893961 OVCAR4 CCLE Cell Line Gene CNV Profiles -1.0 -1.40162 BRD-K99546030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47368 cricetulus Phosphosite Textmining Biological Term Annotations 1.0 null abnormality of the umbilicus HPO Gene-Disease Associations 1.0 null ZNF547 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.3043 Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26777 CRCGN011_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6968 CAMSAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61598 CRCGN014_HEPG2_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.95718 EPB41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46212 neuroectodermal tumor DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.310652 seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.17845 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.997535 CRCGN015_HEPG2_48H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54036 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.820666 FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.51 imatinib_homo sapiens_gpl96_gds3045 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4892-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K59491389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85054 SYNGAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28487 ARRB1 Hub Proteins Protein-Protein Interactions 1.0 null Kainic Acid CTD Gene-Chemical Interactions 1.0 null hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2635 inner CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.979503 GSE217694_3_v_2_pold1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Varicosity COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.904 Coma CTD Gene-Disease Associations 1.0 1.40036 GSE216043_10_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null CRCGN014_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59584 plasma membrane part GO Cellular Component Annotations 2015 1.0 null SNU626 CCLE Cell Line Gene CNV Profiles -1.0 -1.70258 BRD-K78217087 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03294 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27766 PAIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56069 MACO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24527 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20679 HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.3155 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null TFRC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3971 RARA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 91.8702 periventricular stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6046 BRD-K82619993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26706 Apnea CTD Gene-Disease Associations 1.0 1.06261 homeostasis/metabolism phenotype MPO Gene-Phenotype Associations 1.0 null SUCLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.084 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5187-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.62393 TALTIRELIN DGIdb Drug Targets 2026 1.0 15.1234 decreased thyroxine level MGI Mouse Phenotype Associations 2023 1.0 null RELT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74122 Growth Hormone-Secreting Pituitary Adenoma DisGeNET Gene-Disease Associations 1.0 null ADGRL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49125 medial (fastigial) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25126 subiculum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.213112 KDM2B-26808549-CHIP-SEQ-REH-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TCEA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28581 bone resorption disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.670996 Thyrotoxicosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.229 subsequent GeneRIF Biological Term Annotations 1.0 null MTLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.509 Anterior paraventricular nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.527 hypothyroidism HPO Gene-Disease Associations 1.0 null abnormal axial skeleton morphology HPO Gene-Disease Associations 1.0 null Mesothelioma_MESO_TCGA-LK-A4O2-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Signal Transduction Reactome Pathways 2014 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null HEATR5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50716 orbital frontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28472 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7462 VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.966342 GDM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Disease Models, Animal CTD Gene-Disease Associations 1.0 1.15223 BRD-K94014921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56294 19286929-SuppTable2n GeneSigDB Published Gene Signatures 1.0 null CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-A90249268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.47144 Thyrotropin-Releasing Hormone Resistance, Generalized DisGeNET Gene-Disease Associations 1.0 null Calcium HMDB Metabolites of Enzymes 1.0 null 496100349_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.39599 Epilepsy, Tonic-Clonic CTD Gene-Disease Associations 1.0 1.15526 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A3L1-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null superficial dorsofrontal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09479 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.94726 superficial stratum of CoPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09479 tm-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.266069 HEKTE CCLE Cell Line Gene Expression Profiles -1.0 -1.51272 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.202 USF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.035 CRCGN017_MCF10A.TP53.M_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.8411 RHOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25274 496100339_HIP_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.113 neuroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062034 cyclic-amp-dependent-protein-kinases Phosphosite Textmining Biological Term Annotations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A952-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23848 SUM159PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.36218 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:I03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.44495 BRD-K77023196 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1635 PDE10A_KO_GDS4542_292_mouse_hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC8638098__F6 PFOCR Pathway Figure Associations 2024 1.0 null CRCGN015_HEPG2_48H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.81941 GSE231648_1_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01092 MRTFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94999 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GT-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73Q-01A-21R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87631 cricetinae Phosphosite Textmining Biological Term Annotations 1.0 null ZNF888 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85427 BRD-K72066653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0558 Dizziness CTD Gene-Disease Associations 1.0 1.14885 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041499 FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE157282_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.67762 Breast cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 23132/87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.65786 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.343421 SPCS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1908 gprotein GeneRIF Biological Term Annotations 1.0 null SREK1IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11414 Dorsomedial nucleus of the hypothalamus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00536 FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2492 BRD-K84514454 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19886 CNST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98051 CRCGN016_MCF10A.TP53.M_24H:P16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.24363 Vomeronasal organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.674 CRCGN014_HEPG2_3H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03545 orbital frontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.960614 cisplatin_mus musculus_gpl339_gds3099 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH1781 CCLE Cell Line Gene CNV Profiles -1.0 -2.46602 abdominal symptom HPO Gene-Disease Associations 1.0 null Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NSA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25395 RCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20589 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3695 BRD-K84707727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17864 functioning pituitary adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.722482 CRCGN015_MCF10A.WT.HP_24H:P17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.064 NRBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37288 Pigmentation disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.149 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.55255 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRDM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49608 ASCL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03841 ELF5-23300383-T47D-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7745-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15397 EEF2K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54366 peduncular subparaventricular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22433 DDHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77711 PACS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2357 raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14773 PRM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91129 CNOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64595 Kidney Chromophobe_KICH_TCGA-KL-8340-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A7-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27552 19061838-TableS15 GeneSigDB Published Gene Signatures 1.0 null BRD-K71857815 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28254 shell of P-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25963 RUNX1-22343733-PBMC-HUMAN-BONEMARROW ChEA Transcription Factor Targets 2022 1.0 null RPS24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02775 abnormality of the endocrine system HPO Gene-Disease Associations 1.0 null TRH Guide to Pharmacology Protein Ligands of Receptors 1.0 null BRD-K57244822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41707 Perturb_4206_KO_Nr2f1_SRP251949 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.2882 MS751 DepMap CRISPR Gene Dependency 1.0 3.12051 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96265 GSE160304,GSE163392_4_v_3_zswim8_human RummaGEO Gene Perturbation Signatures -1.0 null SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.939063 BRD-K56939159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30094 OCI-AML5 COSMIC Cell Line Gene Mutation Profiles 1.0 null Nrd1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.624 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7331-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2591 Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.65517 oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.0484 Confusion CTD Gene-Disease Associations 1.0 1.24997 ERCC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60649 PRICKLE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45007 Cognition Disorders CTD Gene-Disease Associations 1.0 1.64528 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ATF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51094 NCI-H1568 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05217 DGKD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01005 mantle zone of AHy Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09259 Non-odorant GPCRs(Mus musculus) WikiPathways Pathways 2014 1.0 null INO80E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89143 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRRC41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47236 SkeletalMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.9168 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.885503 Leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.098 CRCGN016_MCF10A.TP53.M_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 10.0 KNS42 CCLE Cell Line Gene CNV Profiles -1.0 -1.53658 GSE165334_2_v_0_dabrafenib_human RummaGEO Drug Perturbation Signatures 1.0 null PARP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03587 trh GeneRIF Biological Term Annotations 1.0 null BRD-K11573765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61421 MAFK ENCODE Transcription Factor Targets 1.0 null transfer GeneRIF Biological Term Annotations 1.0 null bed nucleus of the stria terminalis, medioseptal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11573 BRD-K94088431 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.54804 Perturb_4846_KD_ZEB2_SRP059197 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.89799 FOXG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53395 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_3Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.65494 medial habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38286 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50656 PBX1-22567123-OVCAR3-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null basomedial amygdaloid nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89559 cortex of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25254 Adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.497 Laryngeal cartilage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.695 ZNF77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.92851 Disorders of Excessive Somnolence CTD Gene-Disease Associations 1.0 1.01174 BRD-K46588240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82896 Diazepam CTD Gene-Chemical Interactions 1.0 null CRCGN015_HEPG2_48H:G04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.31845 basomedial amygdaloid nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09792 SUM102PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.610499 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.049601 cerebral lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.082058 M6PR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98764 KLHDC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14688 BRD-K37387086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.24828 CCRT CEM BioGPS Cell Line Gene Expression Profiles 1.0 2.39911 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5466-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14457 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23664 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Claw muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.711 throat TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.880781 icSARS CoV_7Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.72072 Hypothyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.547 PCBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01867 hypophysis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.80107 CRCGN015_MCF10A.TP53.M_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.8849 biological_process GO Biological Process Annotations 2015 1.0 null WDR11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84958 RWDD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37059 PMC4909989-ncomms11840-s3.xlsx-Sheet1-The_overlapped_genes_regulated_by_YAP_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null DDX24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.06194 GSE126345_7_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null Mental Disorders CTD Gene-Disease Associations 1.0 1.12461 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8342-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135350_2_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.233 Dendritic branch point COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.646 layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.922948 cerebellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.7338 CEND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18194 RFXAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47476 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Breast - Mammary Tissue GTEx Tissue Gene Expression Profiles 2023 1.0 7.14505 PMC4330252-gni-12-181-s004.pdf-124-GZF1_GZF1 Rummagene Transcription Factor Associations 2026 1.0 null Pilocarpine CTD Gene-Chemical Interactions 1.0 null IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.6743 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 22RV1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.52768 ASS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77886 BRD-K28446462 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07038 Acromegaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.367 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.081207 cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.376586 Nucleus preopticus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.61 decreased circulating levels of thyroid hormone MGI Mouse Phenotype Associations 2023 1.0 null CRCGN017_MCF10A.WT.HP_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15535 FGF22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71699 lower dorsal perifornical nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27222 TPP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65155 BRD-K08730634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39458 MYL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4111 septopallidal core nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3718 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.71726 BRD-K33400588 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81238 TBR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9596 CRCGN011_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.9456 Tanycyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.929 thyrotropin-releasing hormone resistance, generalized OMIM Gene-Disease Associations 1.0 null cholesterol, ldl GAD Gene-Disease Associations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADPRH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63691 r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11858 CRCGN009_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.39839 temporal lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.090705 central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.58249 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20742 ventropallial amygdalopiriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15124 OCT1-27270436-CHIP-SEQ-PROSTATE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Dorsal raphe nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.709 avian pallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.229299 CHMP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37451 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.986504 agonists Phosphosite Textmining Biological Term Annotations 1.0 null r7 part of the dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60878 CLCN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44025 magnocellular superficial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46033 adrenal adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.261245 rna Phosphosite Textmining Biological Term Annotations 1.0 null CRCGN014_HEPG2_24H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.22024 BRD-K83238251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.757 Disease of cellular proliferation DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SU-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5338029__F5 PFOCR Pathway Figure Associations 2023 1.0 null thyroid hormone resistance syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.787213 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3429-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A3KAW DepMap CRISPR Gene Dependency 1.0 2.01722 BRD-K90556238 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16744 BRD-K48020855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24852 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CASTOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45321 2313287 CCLE Cell Line Gene CNV Profiles 1.0 1.63627 Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10053 LRRC8D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43495 NARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60528 medial habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.923221 Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null GSE126345_4_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K83934572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70049 UQCRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01827 PCYT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17615 Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.39355 A-9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.734 L1TD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01241 RER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58459 D283MED CCLE Cell Line Gene CNV Profiles 1.0 1.80143 subcellular GeneRIF Biological Term Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7079-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Class A/1 (Rhodopsin-like receptors) Reactome Pathways 2024 1.0 null transmembrane signaling receptor activity GO Molecular Function Annotations 2015 1.0 null Visual cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.246 Type 2 diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4179 Hindbrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.457 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.14769 dipyrocetyl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11774 cisplatin_mus musculus_gpl339_gse6206 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.4848 ZNF606 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19304 EN COSMIC Cell Line Gene Mutation Profiles 1.0 null H2BC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70021 BRD-K64958595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48189 APLP2_KO_GDS4414_536_mouse_adult cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MGA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3938 ZBTB26 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6742 ESYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5193 dorsal septopreoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26436 KMCH1 DepMap CRISPR Gene Dependency 1.0 3.43553 EN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32924 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051212 496100503_HIP_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.40656 Functioning pituitary adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.444 DISP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28511 KP2 Achilles Cell Line Gene Essentiality Profiles 1.0 1.11876 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.33299 HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null vesicles Phosphosite Textmining Biological Term Annotations 1.0 null KLM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.62922 Infundibulum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.303 MAFF ENCODE Transcription Factor Targets 1.0 null POU5F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52164 organ system benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.397098 kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.644074 496100313_HIP_possible Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21066 BRD-K35209334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6922 regulation of biological process GO Biological Process Annotations 2015 1.0 null NCIH2081 CCLE Cell Line Gene CNV Profiles -1.0 -1.42659 CRCGN015_HEPG2_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.524 taltirelin Guide to Pharmacology Chemical Ligands of Receptors 1.0 null BRD-K18864235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10915 BRD-K06956443 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.35352 BRD-K28932578 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43194 BRD-K23342427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10526 CRCGN015_HEPG2_48H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64673 Zona fasciculata TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.543 ZNF317 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.8363 BRD-A89947015 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39204 PTPRU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63001 PCDH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97324 APOD_OE_GDS3913_489_mouse_Cerebellum GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hypophysis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null anteromedial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.942283 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC202 CCLE Cell Line Gene Expression Profiles 1.0 1.45223 CRCGN013_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17944 GSE135030_11_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null ckii Phosphosite Textmining Biological Term Annotations 1.0 null NFS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59539 PPHLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75154 lateral hypothalamic area, mammillary region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.982628 SIRT1_KO_GSE28790_47_mouse_brain (3 mo) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051171 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GX-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60144139 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.09169 paradoxical GeneRIF Biological Term Annotations 1.0 null ETS1-22383799-G1ME-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TBX20 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.743 Inferior colliculus, external nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16753 simply GeneRIF Biological Term Annotations 1.0 null hypertension DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.228333 ZBTB18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7063 Kidney Diseases CTD Gene-Disease Associations 1.0 1.01549 GSE128076_1_v_0_doxycycline_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13897 AFG3L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01472 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7834-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K04336022 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0384 LHX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1364 p2 portion of the parabrachial pigmented nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03755 Zona glomerulosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.772 C32 Achilles Cell Line Gene Essentiality Profiles 1.0 1.06745 Generalized Thyroid Hormone Resistance DisGeNET Gene-Disease Associations 1.0 null PMC9692021-Table_4.xlsx-Table_S4-Table_S4_405_DEGs_of_RA_synovial_tissues_between_NFIL3-high_and_NFIL3-low_group_NFIL3 Rummagene Transcription Factor Associations 2026 1.0 null GSE178714_5_v_0_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null JHH7 CCLE Cell Line Gene CNV Profiles -1.0 -1.46665 SLC25A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67744 AVL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15831 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.912663 NIPSNAP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85007 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A23B-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE173873_1_v_3_stra8_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.23695 GSE112763,GSE112767_4_v_5_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.101 BRD-K49040541 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73772 Melanotroph TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.63 CRCGN017_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34919 abnormality of the face HPO Gene-Disease Associations 1.0 null BRD-K29908513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00488 Perturb_7682_KD_HNRNPK_SRP111756 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.00702 Inner nuclear layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.979 HNF4G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43707 lateral septal nucleus, intermedio-ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21862 BRD-K33371292 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77056 CDK4_knockdown_143_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.45141 posterior (caudal) superior temporal cortex (area 22c)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01587 Adrenal adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.229 Foxo3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.7172 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.581 Paraventricular hypothalamic nucleus, magnocellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0393 Congenital hypothyroidism DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 JHUEM3 CCLE Cell Line Gene CNV Profiles 1.0 1.57143 NDUFA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66123 BRD-K10505056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.10745 BRD-K18454119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0031 BRD-K43341506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86255 MRPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40652 metencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.72832 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.40524 POLR2G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08992 CRCGN010_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.89775 peduncular part of dorsomedial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18978 Foxl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.6692 APLP2_KO_GDS4414_534_mouse_adult cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null plexiform layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93881 motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.72377 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NC-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01803 ZNF507 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59557 Lung squamous cell carcinoma_LUSC_TCGA-18-3416-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Obesity HuGE Navigator Gene-Phenotype Associations 1.0 null Nucleus preopticus medialis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.772 PMC10828500-41467_2024_44701_MOESM4_ESM.xlsx-ST12-Unnamed_7_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null CCND2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42573 muscular hypotonia HPO Gene-Disease Associations 1.0 null metencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ZNF233 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86064 ZNF808 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00104 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.82837 phenotypic abnormality HPO Gene-Disease Associations 1.0 null Johanson-Blizzard syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 CCNB1IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32531 primary motor cortex (area M1, area 4)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18568 17660535-TableS4c GeneSigDB Published Gene Signatures 1.0 null CDC25C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19913 CILP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45811 HCC1428 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 EWS-FLI1-20517297-SK-N-MC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.146246 Paraventricular nucleus of hypothalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.165 ANKRD13C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55827 posterior part of anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81967 CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3821 Mewo GDSC Cell Line Gene Expression Profiles 1.0 1.74107 ROVATIRELIN DGIdb Drug Targets 2026 1.0 3.78086 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02931 BARX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39229 PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.927895 DNAJB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46201 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YT COSMIC Cell Line Gene Mutation Profiles 1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.636 abnormal muscle tone HPO Gene-Disease Associations 1.0 null FBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02571 inferior occipital gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13461 Ganglion cell layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.478 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KK-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DBTRG05MG CCLE Cell Line Gene Expression Profiles -1.0 -2.65803 BRD-K14414396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57462 GSE201042_6_v_1_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PRECLH CCLE Cell Line Gene Expression Profiles -1.0 -1.89554 medial (main) part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24303 GSE197117_0_v_1_kdm6b_mouse RummaGEO Gene Perturbation Signatures 1.0 null septostriatal part of the olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10255 BCAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33414 NCIH522 CCLE Cell Line Gene CNV Profiles -1.0 -3.01755 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.955835 NUFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35494 SK-MEL-28 COSMIC Cell Line Gene Mutation Profiles 1.0 null GH3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.234 plexiform layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05005 BRD-K79199168 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56074 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8637-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06006 VAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87601 Thyrotropin-releasing hormone receptor signaling pathway PANTHER Pathways 1.0 null SCA1_Knock-in_GDS1756_231_mouse_Cerebellum tissue - 4 weeks of age GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15463 Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30269 NCIH508 CCLE Cell Line Gene Expression Profiles 1.0 1.70921 cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041157 RAMAC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26649 Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Medial septum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.075 mantle zone of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04103 Prostate adenocarcinoma_PRAD_TCGA-CH-5751-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6791490__F3 PFOCR Pathway Figure Associations 2024 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.25101 RABGEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.90801 CRCGN017_MCF10A.TP53.M_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26777 Sarcoma_SARC_TCGA-DX-A1KY-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1004 olfactory tubercle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.57783 Hypothalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.435 CRCGN012_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.60955 STRN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90473 POLR2A ENCODE Transcription Factor Targets 1.0 null lateral geniculate body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.191068 NADK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07369 Peptide GPCRs(Mus musculus) WikiPathways Pathways 2014 1.0 null Amacrine cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.672 SCN1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51143 signal transducer activity GO Molecular Function Annotations 2015 1.0 null TBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1945 Neuroactive ligand-receptor interaction KEGG Pathways 2026 1.0 null orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21907 embryonic kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.657866 EPPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69618 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15573 HCC2279 CCLE Cell Line Gene CNV Profiles 1.0 1.89754 Cholesterol, LDL dbGAP Gene-Trait Associations 1.0 0.181412 DCTD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89637 BRD-K96154586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00754 Gastrin-CREB signalling pathway via PKC and MAPK Reactome Pathways 2014 1.0 null posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.839045 CD79B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59938 abnormal circulating glucose level MPO Gene-Phenotype Associations 1.0 null lung BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.56504 periventricular stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05634 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null CGNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18736 CRCGN009_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2343 CRCGN017_MCF10A.WT.HP_24H:N17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9935 Hyperprolactinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.27 Memory Disorders CTD Gene-Disease Associations 1.0 1.62445 BRD-K58408512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40238 CRCGN016_MCF10A.WT.HP_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.7988 hypothalamus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959223 GSE216988,GSE216989_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.11624 inner SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33133 HTK CCLE Cell Line Gene Expression Profiles -1.0 -2.38561 outside GeneRIF Biological Term Annotations 1.0 null succinate-CoA ligase complex (ADP-forming) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.928 IRF2 JASPAR Predicted Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4396 lysine Phosphosite Textmining Biological Term Annotations 1.0 null NCI-H446 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 JK1 CCLE Cell Line Gene Expression Profiles 1.0 3.22652 PLEKHB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65385 PMC5655367__F4 PFOCR Pathway Figure Associations 2023 1.0 null Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24091 alar part of peduncular hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30067 GUF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57822 WDR75 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22282 GSE174701_5_v_8_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null Ribbon synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.782 Perturb_2382_KD_ERBB2_SRP045322 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.82864 VEZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7305 PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05263 H2BC15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07314 hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.42206 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20299 posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04511 Disease Reactome Pathways 2014 1.0 null Brain Diseases CTD Gene-Disease Associations 1.0 1.59172 cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046166 Ciliary neurotrophic factor receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.091 Thoracic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 PAS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.905 Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08176 bipolar affective disorder GWASdb SNP-Phenotype Associations 1.0 0.516504 Rectum adenocarcinoma_READ_TCGA-AH-6643-11A-01R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC1_KO_GDS2294_67_mouse_embryonic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K89232006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20104 CRCGN011_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.24285 controlled GeneRIF Biological Term Annotations 1.0 null 5637 DepMap CRISPR Gene Dependency 1.0 2.2001 BRD-K06029218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31161 BRD-K97106314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76087 RERFLCSQ1 DepMap CRISPR Gene Dependency 1.0 4.45193 anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.848578 membrane-bounded vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049355 NKX6-1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8577 SOX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02839 BRD-K73025852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83671 FRTL-5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.945 BRD-K02979518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31566 Perturb_9885_KD_HNRNPL_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.7861 PPWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29381 Perturb_8943_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.315 BRD-K15647573 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1557 ING5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94687 Median nucleus of thalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.477 HCC1599 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K10385824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.23183 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3124 BRD-K35654724 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58787 abnormal circulating thyroxine level MPO Gene-Phenotype Associations 1.0 null cholesterol GAD Gene-Disease Associations 1.0 null Scolopidium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.424 Cortical amygdalar area, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64171 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-UC-A7PF-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7397-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0303 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4723-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.55125 BORCS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5594 BRD-K01667746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12219 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.574 CRCGN016_MCF10A.TP53.M_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.3444 lbm GeneRIF Biological Term Annotations 1.0 null BRD-K36090848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79246 OVCAR8 BioGPS Cell Line Gene Expression Profiles 1.0 1.24031 CPLANE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29269 cognitive disorder GWASdb SNP-Disease Associations 1.0 0.668836 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K57170492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24542 Primary Hypothyroidism DisGeNET Gene-Disease Associations 1.0 null RHEB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.06381 COX6A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0684 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.908105 plasma GeneRIF Biological Term Annotations 1.0 null BRD-K33104513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3216 primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.74885 ZNF217 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66657 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Ebolavirus(ZEBOV)_1day_Liver_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.26424 Lung squamous cell carcinoma_LUSC_TCGA-98-8022-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CJUN-26792858-CHIP-SEQ-BT549-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K33689641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24807 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23782 Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61089 dorsal part of alar p2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16377 496100353_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.29153 GSE185865_0_v_1_celf6_human RummaGEO Gene Perturbation Signatures -1.0 null Recurrent axon collateral COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.679 NDUFA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81253 phenylalanine Phosphosite Textmining Biological Term Annotations 1.0 null EMX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3467 MLXIPL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4377 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Coarse Facial Features DisGeNET Gene-Phenotype Associations 1.0 null CAL-39 GDSC Cell Line Gene Expression Profiles 1.0 1.53032 RAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82342 ARHGAP21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57361 ESRRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8427 adenohypophysis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.17358 Serotonergic neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.993 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32844 hypopituitarism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.23666 496100654_HIP_no dementia_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.89762 regions GeneRIF Biological Term Annotations 1.0 null PMC7791134__F3 PFOCR Pathway Figure Associations 2024 1.0 null pioglitazone_mus musculus_gpl1261_gds4413 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_3H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6788 cingulate gyrus, retrosplenial part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.93062 PNPLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14675 accumbens nucleus, shell domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34642 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5000-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE81803,GSE81912_4_v_1_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ANKRD23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27075 urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.663555 Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.558 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RARA_01_51 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60881 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.187 MBD3L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65319 Vascular Diseases CTD Gene-Disease Associations 1.0 1.02262 FOXP2-23625967-PFSK-1 AND SK-N-MC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null A-VN-1203-2004(H5N1)_Day1-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.57008 receptors Phosphosite Textmining Biological Term Annotations 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUO-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Optic lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.574 PSMB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62805 strychnine-hcl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13138 CNOT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75431 CHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.294 ARRB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE135350_2_v_7_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null 14767473-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null PRMT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0949 GSE201042_2_v_1_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SMAD4-21799915-A2780-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.997535 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A40J-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PFDN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 6.33386 Twitch muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.886 PMC11801220-NIHMS2038999-supplement-14.xlsx-Exc-BNC2-gene_BNC2 Rummagene Transcription Factor Associations 2026 1.0 null RBM28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13269 HGC27 CCLE Cell Line Gene CNV Profiles -1.0 -1.32582 GSE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02416 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.1656 PMC11801220-NIHMS2038999-supplement-15.xlsx-Exc-BNC2-gene_BNC2 Rummagene Transcription Factor Associations 2026 1.0 null Central Hypothyroidism DisGeNET Gene-Disease Associations 1.0 null ACTL6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03895 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 IPMK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30766 SLC6A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84205 Piriform-amygdalar area, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0393 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47005 Alprazolam CTD Gene-Chemical Interactions 1.0 null BRD-K63919349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47334 outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.937139 SG231 DepMap CRISPR Gene Dependency 1.0 16.4657 SNCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25335 ATP6V1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01301 HOP92 BioGPS Cell Line Gene Expression Profiles -1.0 -1.22808 vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042327 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.284 trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.561644 completely GeneRIF Biological Term Annotations 1.0 null Medial mammillary nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.045 BRD-K74039237 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34135 COR-L279 GDSC Cell Line Gene Expression Profiles 1.0 1.69641 Acute Myeloid Leukemia_LAML_TCGA-AB-3009-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null METRH DGIdb Drug Targets 2026 1.0 7.56171 GADD45GIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35177 JJN-3 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 PLCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27922 Gonadotrophic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.889 Peptide GPCRs(Homo sapiens) WikiPathways Pathways 2014 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65F-01A-21R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SEPHS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.78932 Delirium CTD Gene-Disease Associations 1.0 1.28395 BRD-K83931007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43616 all GWASdb SNP-Phenotype Associations 1.0 0.043223 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05117 DLAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73944 KIFC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37164 Postpiriform transition area, layers 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31446 polymorphism GeneRIF Biological Term Annotations 1.0 null BRD-K41714444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30527 BRD-K10343715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44209 Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2808-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRS3P_KO_GDS1219_305_mouse_brown preadipocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Hypothyroidism DisGeNET Gene-Disease Associations 1.0 null NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.8207 abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.141966 decreased circulating prolactin level MPO Gene-Phenotype Associations 1.0 null JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23782 GSE169152_5_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null 496100303_HIP_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16493 Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.254 TAF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37804 SJSA1 Achilles Cell Line Gene Essentiality Profiles 1.0 2.6983 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.90089 MTF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5944 BRD-K41169041 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25603 GSE221004_3_v_2_prdm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5629 Catalepsy CTD Gene-Disease Associations 1.0 1.03345 PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null GSE158431_5_v_1_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A.WT.HP_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.52112 Subpharyngeal region TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.365 HNF4G JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9324 cerebral gray matter TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.173044 dorsomedial preoptic area, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17043 BRD-K14359826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48311 KANSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66098 DDAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34827 AGPAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42739 Prostate adenocarcinoma_PRAD_TCGA-FC-7708-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFI-21473784-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_HEPG2_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.93298 Parkinson's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.078 GRPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51217 CRCGN012_HEPG2_24H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.36454 A_CA_04_2009_4dayMOI-10^3_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.51461 BRD-K67862892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21867 19074878-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GSE81803,GSE81912_3_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null abnormality of the immune system GWASdb SNP-Phenotype Associations 1.0 0.061106 TMEM151B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55445 Prostate adenocarcinoma_PRAD_TCGA-VP-A87C-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.36511 GSE110178_1_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K09711841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14582 DBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59702 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.610861 BRD-K95323755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00798 gproteins GeneRIF Biological Term Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RGS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03144 cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32991 PCNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04796 depression GWASdb SNP-Phenotype Associations 1.0 0.676017 Pituitary gland tumor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.278 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.34124 HSF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.1411 LIVF001-019 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.91654 496100434_HIP_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.70376 blood GTEx Tissue Gene Expression Profiles -1.0 -1.68266 Subthalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.824 influenza DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.256652 Autoimmune disease of endocrine system DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.216 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7049-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2157 CCLE Cell Line Gene CNV Profiles 1.0 1.54731 ETV4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22415 GSE107581_0_v_1_cd27_human RummaGEO Gene Perturbation Signatures -1.0 null prolactinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.795821 Adrenocorticotropic hormone deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.242 HNRNPUL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00588 thyroid cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.266913 Sleep Disorders CTD Gene-Disease Associations 1.0 1.21043 BALL-1 GDSC Cell Line Gene Expression Profiles 1.0 1.46596 GSE187006_3_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Anterior hypothalamic nucleus, central part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04716 GSE221327_6_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null Panhypopituitarism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.065 cerebellar white matter Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05737 mediodorsal nucleus of thalamus_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.85383 hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27286 superficial gray layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74114 ATAD3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.92382 HCST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16578 neural plate TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.185924 JARID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33441 TFEB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.933 CRCGN015_HEPG2_48H:J17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.22581 Organ system benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.364 plasma Phosphosite Textmining Biological Term Annotations 1.0 null Hypoglycemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.019 JHUEM1 DepMap CRISPR Gene Dependency 1.0 2.70813 Cerebellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.475 Medial amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.03344 SURF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2613 MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6284 HCC2157 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 OVOL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33301 subthalamic nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31662 CDK2_knockdown_146_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.80533 RB_Deficiency_GDS2757_644_mouse_Embryonic livers (day 12.5) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CRCGN011_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.3791 body weight; thinness GAD Gene-Disease Associations 1.0 null periventricular stratum of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.038 SP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15185 BRD-K79753227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82035 Inner plexiform layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.396 CRCGN017_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.2919 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.440642 delavirdine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55445 BRD-K27864398 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50343 MDAMB415 CCLE Cell Line Gene CNV Profiles -1.0 -1.57744 Copula pyramidis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15709 KG-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.60591 phosphorylation GeneRIF Biological Term Annotations 1.0 null hippocampus (hippocampal formation)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3605 JEKO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.89778 Extrinsic component of cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.239 thyroid gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.908387 BRD-K93876350 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02295 MXRA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47384 MYOG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.5324 ZNF585A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59189 amygdala BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.02929 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A902-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null their GeneRIF Biological Term Annotations 1.0 null amygdaloid complex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.830382 abnormality of the calvaria HPO Gene-Disease Associations 1.0 null ZFP92 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23625 POU3F1-26484290-ESCSS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.525 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4635-01A-02R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null germ cell and embryonal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.230063 COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.7791 HES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00581 SPHK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77761 hippocampus (hippocampal formation)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05605 Congenital hypothyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.667 cv-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.574916 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.507273 BRD-K11643336 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48841 CRCGN015_HEPG2_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.30131 BRD-K85567359 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09156 CRCGN009_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.85314 abnormal pituitary hormone level MPO Gene-Phenotype Associations 1.0 null CRCGN015_HEPG2_48H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.03494 spanning component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.852042 ZNF497 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92643 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.379256 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.037 regulation of cellular process GO Biological Process Annotations 2015 1.0 null Perturb_8941_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 anterior lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.16604 CRCGN011_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.55685 CRCGN013_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.17345 Primary somatosensory area, trunk, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28352 SKN-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54341 BRD-K10483446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85558 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.65606 HS-578-T COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 biological regulation GO Biological Process Annotations 2015 1.0 null BRD-K38748890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49359 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.00179 GSE128634,GSE128636_1_v_3_foxo1_human RummaGEO Gene Perturbation Signatures 1.0 null dimerization Phosphosite Textmining Biological Term Annotations 1.0 null P4HA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5602 TIGAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63945 Brain Lower Grade Glioma_LGG_TCGA-HT-7481-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K68823900 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34145 VASH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57152 primary motor cortex (area M1, area 4)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09524 SNU213 DepMap CRISPR Gene Dependency 1.0 2.72827 BRD-K08715132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06581 GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null PUS7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8546 Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.025 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.4114 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4763-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RIMS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48933 ZNF845 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01404 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50572 CRCGN017_MCF10A.TP53.M_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54774 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15734 NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44015 HOXC8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 12.8949 HOXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05563 BRD-K17416171 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16431 BRD-K68617666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85853 CRCGN009_HEPG2_24H:L07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8708 SUPV3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24693 superficial stratum of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83424 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5694-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HJ-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5692-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null peduncular (caudal) hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16845 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.943185 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.672324 Acute Myeloid Leukemia_LAML_TCGA-AB-2959-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DPP3_OE_GDS2653_650_human_IMR-32 neuroblastoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NN-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7791134__F3 PFOCR Pathway Figure Associations 2023 1.0 null PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.7083 brain stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.65257 Immunodeficiency 40 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.184 COS cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.401 CRCGN017_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66584 cell type benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.836017 496100489_HIP_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.65233 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3431-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81916 Dorsal globus pallidus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.584 Conn's syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.361 BC-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.94535 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050502 ARGFX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5165 Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K03852663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00464 plasma membrane GO Cellular Component Annotations 2015 1.0 null raphe nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.443731 BRD-K98545272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03448 Pituitary adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.726 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15915 MCAS COSMIC Cell Line Gene Mutation Profiles 1.0 null angular gyrus, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.869713 FOXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89058 CRCGN009_HEPG2_24H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.9332 Adrenocortical carcinoma_ACC_TCGA-OR-A5JW-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sox7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.0424 increased circulating glucose level MGI Mouse Phenotype Associations 2023 1.0 null BRD-A66025870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46944 umbilical hernia HPO Gene-Disease Associations 1.0 null CHTF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76378 GSE173578_1_v_0_atf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07098 MYB_01_44 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58722 Perturb_8953_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 19.0 Lateral dorsal nucleus of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43503 G protein-coupled receptor heterodimeric complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.798 abnormality of skeletal morphology HPO Gene-Disease Associations 1.0 null PMC8803621-mmc6.xlsx-Sup_Fig5A_genes_list-Genes_with_following_MEF2_motifs_around_their_TSS_CTAWWWATA_RSRFC4_Q2_MEF2_Q6_01_MEF2_03_MEF2_02_RSRFC4_Q2_from_GSEA_MEF2A Rummagene Transcription Factor Associations 2026 1.0 null Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14254 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.321 Zona reticulata TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.509 Cortical amygdalar area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40518 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.16191 BRD-K03610256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62999 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NV-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100312_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.6338 gh3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.80107 Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null adenoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.228234 Major island of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.05496 Acromegaly DisGeNET Gene-Disease Associations 1.0 null PMC10342783__F9 PFOCR Pathway Figure Associations 2024 1.0 null pool GeneRIF Biological Term Annotations 1.0 null Congenital Hypothyroidism DisGeNET Gene-Disease Associations 1.0 null CRCGN012_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0885 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3370-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null basal ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069129 mantle zone of PHyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11197 Rectum adenocarcinoma_READ_TCGA-EI-6514-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GF-A4EO-06A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.447192 FGD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96266 GSE218580_1_v_4_fentanyl_mouse RummaGEO Drug Perturbation Signatures 1.0 null Activin B complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.742 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.71042 tails GeneRIF Biological Term Annotations 1.0 null GH4-C1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.228 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6023-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pars tuberalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.066 TCCSUP CCLE Cell Line Gene Expression Profiles -1.0 -1.51797 GPR161 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.77095 Brain Lower Grade Glioma_LGG_TCGA-P5-A77X-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K71544970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09334 GSE210885_0_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.83697 PMC5472759-ncomms15770-s2.xlsx-KIRC_mean_chr8_GISTIC_CN_by_gen-Supplementary_Data_1_TCGA_KIRC_mean_CN_near_MYC_MYC Rummagene Transcription Factor Associations 2026 1.0 null GATA1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null rc4b/c1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.398 decreased circulating ghrelin level MGI Mouse Phenotype Associations 2023 1.0 null faster GeneRIF Biological Term Annotations 1.0 null UBA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58317 endocytosis Phosphosite Textmining Biological Term Annotations 1.0 null pituitary gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.171036 cytoplasmic vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.170629 Superior colliculus, superficial gray layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41454 CR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64031 thalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07195 pituitary-dependent Cushing's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.235 e2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.803 intermediate stratum of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15172 Suprachiasmatic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.252 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44324 ACHN BioGPS Cell Line Gene Expression Profiles -1.0 -0.952858 Brain stem TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN016_MCF10A.WT.HP_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48367 abnormal facial shape HPO Gene-Disease Associations 1.0 null GCM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62131 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04732 VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27344 Thyroid nodule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.603 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 125.351 abnormal behavior MPO Gene-Phenotype Associations 1.0 null bone disease GWASdb SNP-Disease Associations 1.0 0.245187 TPSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15142 dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.67313 BRD-K94506829 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49671 CRCGN010_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.07306 KM12 BioGPS Cell Line Gene Expression Profiles 1.0 0.91348 Medial amygdalar nucleus, posterodorsal part, sublayer c Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88874 CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1161 internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.502357 UACC893 DepMap CRISPR Gene Dependency 1.0 7.56375 CRCGN013_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.01044 LU99 CCLE Cell Line Gene CNV Profiles 1.0 1.52277 TBX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8569 chimeric Phosphosite Textmining Biological Term Annotations 1.0 null decreased prolactin level MPO Gene-Phenotype Associations 1.0 null BRD-K47966145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59161 S117 CCLE Cell Line Gene Expression Profiles 1.0 1.82483 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.118 Pituitary gland tumor cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.376 Basolateral amygdalar nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35509 RKO-E6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44298 BRD-K52842821 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17423 TM6SF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09518 19192944-TableS4 GeneSigDB Published Gene Signatures 1.0 null FOXH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1498 TMEM191C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71508 CRCGN016_MCF10A.TP53.M_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.73202 CFTR_Deficiency_GDS1843_191_mouse_Lungs - Animals examined at 3 weeks of age GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null intrinsic component of plasma membrane GO Cellular Component Annotations 2015 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5095-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UTP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77894 BRD-K28510065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84641 Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KO-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBXN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9156 CRCGN017_MCF10A.TP53.M_24H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0802 H-NS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.477 KLHDC8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62743 TC-71 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.11275 H3K27me3_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDE12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05372 Ascl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.6433 CRCGN015_HEPG2_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.88355 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.954877 SELENOI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.40714 NCIH2052 DepMap CRISPR Gene Dependency 1.0 2.34549 EPS15L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85218 PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18405 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03405 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZW-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K55053106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75735 BRD-K53636670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11947 GSE101239_3_v_2_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal triiodothyronine level MPO Gene-Phenotype Associations 1.0 null PORCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54394 CCDC50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51726 Perturb_13957_KO_YAP1_SRP194022 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.38786 m1 part of parabrachialis pigmentosus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07404 Chlordiazepoxide CTD Gene-Chemical Interactions 1.0 null OSBPL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24545 decreased activity of thyroid gland MGI Mouse Phenotype Associations 2023 1.0 null abnormal depression-related behavior MPO Gene-Phenotype Associations 1.0 null MFM-223 GDSC Cell Line Gene Expression Profiles -1.0 -1.50125 effect GeneRIF Biological Term Annotations 1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.96636 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VG-01A-31R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7229-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN010_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.64505 bone resorption disease GWASdb SNP-Disease Associations 1.0 0.88034 sheehan syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.782298 cerebellum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ventral entopeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20327 midazolam Guide to Pharmacology Chemical Ligands of Receptors 1.0 null ACTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63136 stratum oriens of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04932 phospholipase C-activating G protein-coupled receptor signaling pathway GO Biological Process Annotations 2023 1.0 null RIOK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74669 kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.56284 Cnidoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.541 CRCGN016_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.739 abnormal homeostasis MPO Gene-Phenotype Associations 1.0 null MARK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19005 TBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6022 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null LbetaT2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.719 molecular_function GO Molecular Function Annotations 2015 1.0 null att-20 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.16648 CEBPB ENCODE Transcription Factor Targets 1.0 null HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22846 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.932198 plasma membrane LOCATE Curated Protein Localization Annotations 1.0 null 496100288_HIP_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.60745 inner SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.886186 olfactory lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.101128 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4969-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.6291 MV411 Achilles Cell Line Gene Essentiality Profiles 1.0 1.54368 Adenohypophysis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.239 mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11974 Cholinergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.719 ADA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17162 CTBP2-25329375-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PPIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25457 Nodulus (X), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00378 CRCGN008_HEPG2_24H:G04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.51015 HELA BioGPS Cell Line Gene Expression Profiles -1.0 -1.92567 GSE76854,GSE90855_1_v_0_acss2_mouse RummaGEO Gene Perturbation Signatures -1.0 null layer 2 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40613 EXOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94216 BRD-K04508260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38835 OVCAR5 BioGPS Cell Line Gene Expression Profiles -1.0 -0.944596 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_8947_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE101239_3_v_0_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null IST-SL2 COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 GSE112761,GSE112767_1_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Thinness HuGE Navigator Gene-Phenotype Associations 1.0 null TCF4-23295773-U87-HUMAN ChEA Transcription Factor Targets 2022 1.0 null D-283MED COSMIC Cell Line Gene CNV Profiles 1.0 2.2355 abnormality of immune system physiology GWASdb SNP-Phenotype Associations 1.0 0.100135 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GPCR downstream signaling Reactome Pathways 2014 1.0 null Copula pyramidis, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.18208 NOB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9819 ALLSIL CCLE Cell Line Gene Expression Profiles 1.0 1.43725 HMGN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54632 amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43608 KLF5-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null IZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00209 Hyperthyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.543 Cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.032 Signal Transduction Reactome Pathways 2024 1.0 null CRCGN011_HEPG2_24H:A09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80555 FOXP2-23625967-PFSK-1-AND-SK-N-MC-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K18763924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3834 Lung squamous cell carcinoma_LUSC_TCGA-56-7580-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K47391428 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87196 postcentral gyrus, left, bank of the central sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.958052 urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.655024