association dataset threshold value standardized value Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 NOL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44826 hsa-miR-548t TargetScan Predicted Conserved microRNA Targets 1.0 0.219115 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE199255,GSE199356_4_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE241036_4_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles 1.0 1.2571 negative regulation of cellular component organization GO Biological Process Annotations 2015 1.0 null GTEX-PWOO-1026-SM-48TCN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Pectoral muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.096 GTEX-X3Y1-0226-SM-3P5Z5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.86748 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35502 Mutator focus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.569 MDAMB415 CCLE Cell Line Gene Expression Profiles -1.0 -1.8592 SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10155 bone disease GWASdb SNP-Disease Associations 1.0 0.235828 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-QDT8-0526-SM-3NMD8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28553 Heart primordium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.976 abnormality of the immune system GWASdb SNP-Phenotype Associations 1.0 0.056118 ZNF382 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.441 outer CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26936 Muscle stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.258 Flight muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.609 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-OIZH-0326-SM-2HMKC GTEx Tissue Sample Gene Expression Profiles 1.0 1.09341 cell part LOCATE Curated Protein Localization Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA4_INACTIVATION_GDS3663_519_mouse_Endothelial-derived cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TE-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 ZBTB11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69712 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146612_2_v_0_amiodarone_human RummaGEO Drug Perturbation Signatures 1.0 null medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.828966 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.919974 GTEX-OHPK-0326-SM-2HMJO GTEx Tissue Sample Gene Expression Profiles 1.0 0.904747 Skeletal muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.31 Dystrobrevin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.592 GSE216273,GSE216292_14_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null BJAB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.69235 GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 CEBPZ_02_05 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 4.0 BICR 10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09347 GTEX-W5X1-0826-SM-3GILN GTEx Tissue Sample Gene Expression Profiles 1.0 0.825724 GTEX-OXRP-0926-SM-48TC1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87349 GSE92364_0_v_4_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNURF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73971 MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.864255 striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.37696 Nervous System Malformations CTD Gene-Disease Associations 1.0 1.03197 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29372 H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE205332_2_v_0_queuine_human RummaGEO Drug Perturbation Signatures 1.0 null Plantaris muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.668 negative regulation of biological process GO Biological Process Annotations 2015 1.0 null TIA1_KO_GSE54418_263_mouse_spinal cord GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null intermediate stratum of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2873 GSE48812_0_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null Median preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60483 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4694-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-8179-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2J DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.037 CTCF-21964334-BJAB-B-HUMAN ChEA Transcription Factor Targets 2022 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.067 GTEX-RN64-0008-SM-48FEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Simple lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60015 layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.944072 m1 part of paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12628 Uterus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 496100641_PCx_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03104 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.02687 GTEX-SUCS-0326-SM-32PLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.1414 GSE185944_2_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-1278 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23999 Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 SOX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.5904 Proteasome activator complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.976 striatum_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.14266 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046466 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.15158 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.929081 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.877547 CENPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08899 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05437 GSE153189_1_v_0_interferon gamma_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMIM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17867 GTEX-O5YT-0526-SM-32PK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 occipital cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21298 abnormality of lymphocytes GWASdb SNP-Phenotype Associations 1.0 0.525969 HSMM Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.870922 Anteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96441 DARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19175 contractile fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.569664 Adrenocortical carcinoma_ACC_TCGA-OR-A5LP-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.39869 GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles 1.0 1.55641 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.951127 Perturb_13560_OE_Kdm1a_SRP105108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.36814 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.959787 GSE138633_2_v_0_bag3_human RummaGEO Gene Perturbation Signatures 1.0 null Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2355 RCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20589 ZNF722 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00252 LMX1B_KO_GDS3320_57_mouse_embryonic (e11.5) proximal hindlimb bud tissues GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PRMT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66408 Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54569 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16368 ABC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.55712 TCF12 ENCODE Transcription Factor Targets 1.0 null CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EOLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42121 microtubule GO Cellular Component Annotations 2015 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.902913 USP4 Pathway Commons Protein-Protein Interactions 1.0 null dorsomedial preoptic area, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0622 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.03801 HNF4 MotifMap Predicted Transcription Factor Targets 1.0 null Proteasome accessory complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.986 JKAMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35113 GTEX-X585-0011-R11B-SM-46MUZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GSE88819_1_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null posteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12745 NR2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3276 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null layer 3 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17503 GTEX-S4Z8-0526-SM-4AD4T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 myofibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.577164 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null regulation of cellular component organization GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z3-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.69968 NCIN87 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.53787 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40071 GTEX-V1D1-2426-SM-3GAER GTEx Tissue Sample Gene Expression Profiles 1.0 1.59931 GTEX-XXEK-0726-SM-4BRWF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Cardiac muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.964 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4423 USP2 Pathway Commons Protein-Protein Interactions 1.0 null U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.940295 JcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.0261 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BTBD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34692 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null premature death MGI Mouse Phenotype Associations 2023 1.0 null toxin-antitoxin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.79 BE-73-KD75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.380362 Rectum adenocarcinoma_READ_TCGA-CL-5918-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.870431 GSE140576_0_v_2_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29648 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.33261 FOXP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7114 GSE164874_5_v_1_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null t55-gastrocnemius_consensus MoTrPAC Rat Endurance Exercise Training 1.0 2.66226 primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03739 dystrophin-associated glycoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.062 CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-1326-SM-3NM8X GTEx Tissue Sample Gene Expression Profiles 1.0 0.958523 superficial stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06192 hippocampus (hippocampal formation)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.916019 Lung adenocarcinoma_LUAD_TCGA-75-6212-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal heart morphology MPO Gene-Phenotype Associations 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BY-01A-31R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1244 periventricular stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78742 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52809 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Lung adenocarcinoma_LUAD_TCGA-44-3918-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE171837_0_v_3_bortezomib_mouse RummaGEO Drug Perturbation Signatures -1.0 null TGFBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21274 COS domain InterPro Predicted Protein Domain Annotations 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048657 GSE168918_1_v_0_tmprss4_human RummaGEO Gene Perturbation Signatures 1.0 null U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.90682 20630075-AF-3 GeneSigDB Published Gene Signatures 1.0 null PRR15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29361 cellular developmental process GO Biological Process Annotations 2015 1.0 null Fetal Growth Retardation CTD Gene-Disease Associations 1.0 1.08762 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles 1.0 0.935673 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-OIZF-1526-SM-3MJGY GTEx Tissue Sample Gene Expression Profiles 1.0 1.07999 Lung adenocarcinoma_LUAD_TCGA-05-4398-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vascular tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.121207 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-VJYA-1226-SM-3GIJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31092 EIF3M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59434 GSE237040_6_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC1500 CCLE Cell Line Gene CNV Profiles -1.0 -1.90018 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85J-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02979 GSE139975_3_v_0_rnf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PX3G-1526-SM-48U11 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Dorsomedial nucleus of the hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28627 organelle part GO Cellular Component Annotations 2015 1.0 null Proboscis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.553 ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 3.10435 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.991853 PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D Rummagene Transcription Factor Associations 2026 1.0 null hESC_Derived_CD56+_Mesoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.1415 NCI-H1623 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 GTEX-XK95-0008-SM-4AT5G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 NKX2-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3656 Centronuclear myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.035 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.76905 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4881-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157894_1_v_0_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null INTS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73994 heart muscle HPA Tissue Gene Expression Profiles 1.0 1.26708 K029AX DepMap CRISPR Gene Dependency 1.0 2.55692 m band COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.17209 musculoskeletal system disease GWASdb SNP-Disease Associations 1.0 0.141918 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.36591 dorsal preisthmic part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31898 J82 CCLE Cell Line Gene CNV Profiles -1.0 -1.50288 ADAD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95907 Sarcolemma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.577 Anteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77714 multiform (lateral) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.92462 H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARHGEF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0976 CLTC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36805 chaperonin-containing T-complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.836 UBC Pathway Commons Protein-Protein Interactions 1.0 null Distal arthrogryposis type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.424 Primary B cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.886041 M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54456 GTEX-S4Q7-1626-SM-3K2AE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.10838 GSE169571_5_v_4_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null MHCC97-H cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.69 E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null FOSL2 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217156_1_v_3_trpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE226316_11_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null negative regulation of microtubule polymerization or depolymerization GO Biological Process Annotations 2015 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7189 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.964258 immune system disease GWASdb SNP-Disease Associations 1.0 0.050787 Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EFCAB14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.19981 HS729 CCLE Cell Line Gene Expression Profiles -1.0 -1.67917 JcPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7568 Zinc finger, RING/FYVE/PHD-type InterPro Predicted Protein Domain Annotations 1.0 null cardiac muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.313683 GSE203308_8_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Supramolecular polymer COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 TAF7L_KO_GDS2857_556_mouse_ES cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.1461 GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100596_FWM_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.15342 Dorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1111 GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Zinc finger, B-box InterPro Predicted Protein Domain Annotations 1.0 null PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SE5C-0008-SM-4B64J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.83329 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1697 H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07073 FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.0322 Lung adenocarcinoma_LUAD_TCGA-55-6984-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2983-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE133505_5_v_4_myf6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5971-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARL2BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07722 SCD_KO_GSE24243_46_mouse_Skin (8-9 wk) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17909 GTEX-P4PQ-1626-SM-2HMKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.63964 GTEX-X3Y1-0426-SM-3P5Z4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0407 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 IFRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37635 LAMA84 CCLE Cell Line Gene CNV Profiles -1.0 -1.52937 FOXS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1551 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2966 abnormal heart layer morphology MPO Gene-Phenotype Associations 1.0 null Inherited metabolic disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.638 Zinc finger, RING-type InterPro Predicted Protein Domain Annotations 1.0 null MAFF ENCODE Transcription Factor Targets 1.0 null outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00652 lateral trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01752 H4K5ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ubiquitin-like protein ligase activity GO Molecular Function Annotations 2023 1.0 null Weight Gain CTD Gene-Disease Associations 1.0 1.04501 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPJH-0326-SM-3GADU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 LXF289 CCLE Cell Line Gene CNV Profiles -1.0 -1.51766 Body wall muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.021 lingual gyrus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.50748 core part of DTg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48623 GTEX-PWOO-0826-SM-48TCL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040871 negative regulation of microtubule polymerization or depolymerization GO Biological Process Annotations 2025 1.0 null CHORDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.808 MRPL37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48187 Ebolavirus(ZEBOV)_3day_Liver_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.16458 LN235 DepMap CRISPR Gene Dependency 1.0 2.14339 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00996 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1445 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.056823 inner SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10388 microtubule associated complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GTEX-T5JW-1126-SM-4DM5V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 EP300 ENCODE Transcription Factor Targets 1.0 null orbital frontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.939448 Supramolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ATP6AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23339 PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054369 KDM5A ENCODE Transcription Factor Targets 1.0 null ALG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52304 PMC6420765-12864_2019_5550_MOESM5_ESM.xlsx-D4_vs_D9-Unnamed_1_CENPX Rummagene Transcription Factor Associations 2026 1.0 null ion binding GO Molecular Function Annotations 2015 1.0 null Duchenne muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.322 PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Breast Neoplasms CTD Gene-Disease Associations 1.0 1.20361 COP9 signalosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.228 GSE165647_0_v_7_cry2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QDVN-0826-SM-48TZ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles 1.0 1.32578 inner CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37079 NANOG-16153702-HESC-human ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0126-SM-3GIK4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.42357 MZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00971 GSE164874_5_v_0_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23739 TAF2-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE149901_2_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures -1.0 null HH CCLE Cell Line Gene CNV Profiles 1.0 1.35895 HNF4A ChEA Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urinary bladder HPA Tissue Gene Expression Profiles -1.0 -1.34667 Prostate adenocarcinoma_PRAD_TCGA-VP-A87E-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE237040_6_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04631 CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.15949 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HNF4A-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ST18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31432 microtubule cytoskeleton GO Cellular Component Annotations 2025 1.0 null Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.07 YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.245064 Primary visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51892 CASP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15985 PRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45699 r1 part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30799 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00434 amygdaloid complex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.83667 CBX3 ENCODE Transcription Factor Targets 1.0 null GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles 1.0 1.28487 GSE161055,GSE161056_1_v_0_hira_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE154074_1_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-4461 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 abnormal survival MPO Gene-Phenotype Associations 1.0 null Perturb_6422_KD_LOC646329_SRP220725 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.9001 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null chr2_27294815_A_G_b38 GTEx eQTL 2025 1.0 1.06771 posteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73073 HM7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.68176 RMSYM DepMap CRISPR Gene Dependency 1.0 2.77291 GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.37375 GTEX-WEY5-0426-SM-3GIKT GTEx Tissue Sample Gene Expression Profiles 1.0 0.882806 NR3C1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ1-0526-SM-4DXTG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NF-kappaB p50/p65 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.584 Rectus femoris TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.29 POMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43479 VMRCLCD CCLE Cell Line Gene CNV Profiles 1.0 1.56822 GSE48812_7_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null tongueepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 MRPL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34415 GSE223893_11_v_10_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FKBP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6359 lymphopenia GWASdb SNP-Disease Associations 1.0 0.619466 raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27338 H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Left ventricular noncompaction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040732 496100610_TCx_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.87745 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045572 CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bacteriocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.935 GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles 1.0 1.50918 abnormality of the genitourinary system GWASdb SNP-Phenotype Associations 1.0 0.109295 AE-07-IZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.200969 EMX2_Deficiency_GDS3173_607_mouse_Embryonic urogenital epithelium - day 10.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null TP53-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null abnormal heart left ventricle morphology MPO Gene-Phenotype Associations 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08973 19036130-TableS1a GeneSigDB Published Gene Signatures 1.0 null periventricular stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.84011 H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-PSDG-0008-SM-48TE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 SURF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42513 GTEX-O5YW-0126-SM-3LK6D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 PURG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20241 CIAO2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45926 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10785 Cardiac muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.923 Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.4969 Ventromedial hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63328 GTEX-SIU7-1826-SM-2XCE2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.06552 Biceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.117 QGP-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.04551 PAX3_01_359 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.82891 Right_Ventricle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.47821 hsa-miR-593 TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 heart TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.8031 DCAF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76784 UCHL3 Pathway Commons Protein-Protein Interactions 1.0 null intermediate isthmic part of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33112 GTEX-S3XE-0926-SM-4AD4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Hypertrophic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.993 PPP3CB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.99086 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.957383 skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.672913 GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles 1.0 0.928149 Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.21534 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles 1.0 1.08415 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles 1.0 1.4474 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182179_2_v_3_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null medial pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43567 GSE242290_1_v_10_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null HOXC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06058 Z disc COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.39 cytoplasm LOCATE Curated Protein Localization Annotations 1.0 null Kinetoplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.791 CHCHD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06036 GSE237053_1_v_0_comt_human RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3436-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01224 GTEX-S341-1226-SM-4AD5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08358 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ranolazine_mus musculus_gpl1261_gse25767 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null accessory entopeduncular nucleus (post-migratory) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28868 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_3Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.44458 GTEX-PWCY-1726-SM-48TD3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.6538 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22564 GSE65617_2_v_3_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.918756 Calcineurin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.344 posteroventral (inferior) parietal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.85109 NCIH1385 CCLE Cell Line Gene CNV Profiles 1.0 1.38396 GSE217115_3_v_0_alectinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.948809 midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08099 vertebrate muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 premature death MPO Gene-Phenotype Associations 1.0 null GTEX-P44H-0726-SM-48TBT GTEx Tissue Sample Gene Expression Profiles 1.0 0.916644 intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.165 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52951 Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PML body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.963 PcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.84198 Distal myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.617 AP-1 MotifMap Predicted Transcription Factor Targets 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JT-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100315_TCx_no dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.81261 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-7173-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFON-1826-SM-3GILG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.26389 BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.96105 amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.41775 RPIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93882 ZNHIT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2455 GTEX-PSDG-1326-SM-48TD2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14791 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null REC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40694 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal muscle physiology MPO Gene-Phenotype Associations 1.0 null Myofibrillar myopathy 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.175 GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29062 SIN3A ENCODE Transcription Factor Targets 1.0 null myocardial fiber degeneration MPO Gene-Phenotype Associations 1.0 null Eukaryotic translation initiation factor 2B complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.119 NR3C1 ENCODE Transcription Factor Targets 1.0 null VSIG10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66711 Acute Myeloid Leukemia_LAML_TCGA-AB-2849-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AI-0926-SM-48U1F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null r5 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02318 anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.884982 CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.53876 GSE112358,GSE112359_0_v_1_med23_mouse RummaGEO Gene Perturbation Signatures -1.0 null FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.86721 Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA-94-MC54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220593 abnormality of leukocytes GWASdb SNP-Phenotype Associations 1.0 0.093544 CCDC71L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67585 RAB18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51366 PRDM14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57105 GSE241701_4_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles 1.0 1.12651 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09374 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.92091 Myotube TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.085 LYSMD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90691 UBE2I Hub Proteins Protein-Protein Interactions 1.0 null PMC5417597-pone.0176679.s008.xlsx-MLL-TINT_vs_control-Unnamed_1_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.826342 GTEX-TKQ2-0008-SM-4DM5L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE203060_0_v_2_kdm4c_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-0926-SM-3NMBS GTEx Tissue Sample Gene Expression Profiles 1.0 0.871779 GTEX-OOBJ-0326-SM-33HBO GTEx Tissue Sample Gene Expression Profiles 1.0 1.00862 SUDS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24622 captopril_mus musculus_gpl1261_gds3683 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.7252 protein complex GO Cellular Component Annotations 2015 1.0 null negative regulation of supramolecular fiber organization GO Biological Process Annotations 2025 1.0 null ventral linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2355 BATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0556 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.258 superficial stratum of OCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21009 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041833 KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20502 GTEX-TKQ1-0008-SM-4DXSO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.897507 amygdaloid complex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09199 Perturb_12234_KD_STAT3_SRP081918 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE181431_0_v_1_calr_human RummaGEO Gene Perturbation Signatures 1.0 null FOXD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.15 ACADVL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14868 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1274 GSE147366_1_v_2_med13_human RummaGEO Gene Perturbation Signatures -1.0 null OLFM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03921 GTEX-SUCS-1426-SM-4DM5W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 M059K CCLE Cell Line Gene CNV Profiles -1.0 -1.4726 GTEX-PWCY-0826-SM-48TCR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 respiratory system disease GWASdb SNP-Disease Associations 1.0 0.187684 GTEX-QVJO-0008-SM-447AU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-U4B1-1226-SM-4DXT7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 KLHDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23447 Hypertrophy CTD Gene-Disease Associations 1.0 1.50903 superficial stratum of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10795 MDAMB436 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.721771 DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10346 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUJ4-0526-SM-4BOON GTEx Tissue Sample Gene Expression Profiles 1.0 0.976348 Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QX-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8482521-mmc10.xlsx-Upstreme_Regulators_48_hr_MLR-Unnamed_0_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.60319 SAMM50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79697 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06036 GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.49925 Lung adenocarcinoma_LUAD_TCGA-55-A48X-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC3C CCLE Cell Line Gene CNV Profiles -1.0 -1.63639 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.049291 GTEX-WFG7-0726-SM-3GIKO GTEx Tissue Sample Gene Expression Profiles 1.0 0.898259 GTEX-Q2AI-0626-SM-48TZU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 MAGED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36007 Atherosclerosis CTD Gene-Disease Associations 1.0 1.21239 salivary gland GTEx Tissue Gene Expression Profiles 1.0 0.832941 Myoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.958 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06365 Posterior parietal association areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17317 GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles 1.0 1.05472 GSE198826,GSE198911_1_v_2_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-95-7039-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3315 Arteriosclerosis CTD Gene-Disease Associations 1.0 1.02485 GTEX-QMRM-0926-SM-447BR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE217132_0_v_1_pfkfb4_human RummaGEO Gene Perturbation Signatures 1.0 null E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_9752_KO_Rnf20/Rnf40_SRP228497 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.36882 lateral septal nucleus, intermedio-ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25026 Primary somatosensory area, barrel field, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43771 GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles 1.0 1.6112 GSPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98969 PYGM Pathway Commons Protein-Protein Interactions 1.0 null GSE203308_1_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11007 emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04234 Atrophy CTD Gene-Disease Associations 1.0 1.21108 KRTAP13-4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09157 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IK-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Myocardial infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.504 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bone disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.137 GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-XGQ4-1526-SM-4AT6H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 neoplasm by anatomical site GWASdb SNP-Phenotype Associations 1.0 0.047171 abnormal cardiac muscle contractility MGI Mouse Phenotype Associations 2023 1.0 null UCHL5 Pathway Commons Protein-Protein Interactions 1.0 null binding GO Molecular Function Annotations 2015 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE159937_2_v_0_tfcp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null thin ventricular wall MGI Mouse Phenotype Associations 2023 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52951 striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.934874 GTEX-R53T-0326-SM-48FEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 immune system cancer GWASdb SNP-Disease Associations 1.0 0.187684 Prefoldin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.903 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20096 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.4678 Semimembranosus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.633 GTEX-POMQ-0326-SM-2I5FO GTEx Tissue Sample Gene Expression Profiles 1.0 0.978927 RFX5 ENCODE Transcription Factor Targets 1.0 null GSE84462,GSE84762_0_v_1_ezh2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PGR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3649 protein complex binding GO Molecular Function Annotations 2015 1.0 null GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE216273,GSE216292_14_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29506 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MO-1226-SM-4DM5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Congenital structural myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 Inferior colliculus, central nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16587 H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111247_14_v_4_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-RNOR-0826-SM-2TF5C GTEx Tissue Sample Gene Expression Profiles 1.0 0.906929 GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles 1.0 1.07751 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.901869 Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16952 H3K27me3_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-0626-SM-3P61B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE201401_2_v_0_fgfr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40071 GTEX-NPJ7-0008-SM-4E3JS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 transition metal ion binding GO Molecular Function Annotations 2015 1.0 null CYP20A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97296 Poisoning CTD Gene-Disease Associations 1.0 1.21599 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DMS454 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 GTEX-Q734-0326-SM-48U15 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20502 Lung adenocarcinoma_LUAD_TCGA-MP-A4SW-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.953941 RORB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0295 Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.025 ZBTB18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8634 Gout DisGeNET Gene-Disease Associations 1.0 null 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.14766 layer 5 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10408 primary auditory cortex (core)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21809 TAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31562 medial mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16952 dorsal spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90909 posteroventral (inferior) parietal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.78153 polymeric cytoskeletal fiber GO Cellular Component Annotations 2023 1.0 null layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.39465 105KC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31288 WHSC1 ENCODE Transcription Factor Targets 1.0 null hsa-miR-1262 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.862 C zone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.064 r4 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33291 zinc ion binding GO Molecular Function Annotations 2015 1.0 null Intercalated disc COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.582 PDGFRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67778 GSE133070_3_v_1_prss1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Anteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81483 GSE135350_3_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null magnocellular (medial) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.842381 VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12965 NRL_Deficiency_GDS1693_236_mouse_Photoreceptors cells of retinas at P2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.8717 GSE164874_5_v_7_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null asthma GWASdb SNP-Disease Associations 1.0 0.619466 Cardiovascular Diseases CTD Gene-Disease Associations 1.0 1.29996 OCIMY5 CCLE Cell Line Gene CNV Profiles 1.0 1.36146 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 hypertension GWASdb SNP-Disease Associations 1.0 1.02638 principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37317 SKCO1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.03513 connective tissue disease GWASdb SNP-Disease Associations 1.0 0.188633 GSE239898,GSE239899_1_v_0_hiltonol_human RummaGEO Drug Perturbation Signatures 1.0 null GSE191015_0_v_2_gsdmb_human RummaGEO Gene Perturbation Signatures 1.0 null U343 CCLE Cell Line Gene Expression Profiles 1.0 1.45808 reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50118 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDCD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36035 MAP2K2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42864 CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50751 Breast Cancer_Mammary Gland Tissue_GSE3744 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.3842 Thigh TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.915 CDC40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26078 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Organism form TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 retina BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.954024 Perturb_15827_OE_Nrf2_SRP291724 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.3089 GTEX-UJHI-0426-SM-3DB8Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.975749 HIC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5061 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GS-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary somatosensory area, mouth, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09459 SUDHL10 DepMap CRISPR Gene Dependency 1.0 2.32261 Placenta TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4844-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.28057 H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null a band COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.06701 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles 1.0 1.23674 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08311 H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.286 Psoriasis vulgaris_Skin tissue_GSE14905 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.40942 Autosomal recessive limb-girdle muscular dystrophy type 2A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.259 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWOO-1326-SM-48TCJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 TE1 CCLE Cell Line Gene CNV Profiles 1.0 2.21363 POU3F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46376 medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03065 BCL6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1704 cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Neoplasms CTD Gene-Disease Associations 1.0 1.1607 GSE93309_1_v_3_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.0098 Ischemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.448 HCC1806 DepMap CRISPR Gene Dependency 1.0 3.16051 GSE144796_3_v_0_linagliptin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_16_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null NR2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.1266 PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null Mean corpuscular hemoglobin GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.909691 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.980557 regulation of protein complex disassembly GO Biological Process Annotations 2015 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-O5YW-0426-SM-3MJHJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.43 r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03138 enlarged heart MPO Gene-Phenotype Associations 1.0 null PMC10209342-mmc9.xlsx-UBE2D3_interactors-UBE2D3_interactors_used_for_Venn_Diagrams_from_MINT_STRING_UniProt_IntAct_BioGRID_SPEN Rummagene Transcription Factor Associations 2026 1.0 null SF3B6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32694 GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49385 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10U-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ubiquitin-like protein ligase activity GO Molecular Function Annotations 2025 1.0 null GSE145915_0_v_1_pcm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null lower respiratory tract disease GWASdb SNP-Disease Associations 1.0 0.20671 GSE199255,GSE199356_4_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QV44-0526-SM-2S1RE GTEx Tissue Sample Gene Expression Profiles 1.0 1.0102 lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13375 red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0395 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.839913 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZDHHC23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32207 layer 2 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18053 Perturb_15772_KO_Uxt_SRP240277 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-SNMC-0426-SM-4DM5Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895059 orbital frontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.68015 Neural Tube Defects CTD Gene-Disease Associations 1.0 1.03009 Triglycerides Measurement DisGeNET Gene-Phenotype Associations 1.0 null PMC7373278-pone.0236187.s013.xlsx-MDA231genes_overexpressed_in_AR-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null QSOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15071 NRDE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29573 GTEX-X585-0008-SM-46MU4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 PHF8-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Dilated cardiomyopathy 2A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.947 mantle zone of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0604 GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles 1.0 1.49678 PTPN14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36695 H3K4me1_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KIJK CCLE Cell Line Gene Expression Profiles 1.0 1.80396 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 SDF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22862 PMC11511861-41420_2024_2216_MOESM2_ESM.xlsx-siYAP_myc_bound-MYC_targets_from_chipseq_atlas_at_least_2_chip-seqs_over_4_in_A459_MYC Rummagene Transcription Factor Associations 2026 1.0 null lethargy MGI Mouse Phenotype Associations 2023 1.0 null Basolateral amygdalar nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12095 RPS6KA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41856 AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null GSE168697_0_v_1_wdr6_mouse RummaGEO Gene Perturbation Signatures 1.0 null COX7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72764 anteroventral periventricular preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54136 GTEX-QDVN-1126-SM-48TZ7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Declive (VI) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19375 GTEX-U8XE-1226-SM-4E3HN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-P4PP-1626-SM-2HMJF GTEx Tissue Sample Gene Expression Profiles 1.0 1.86337 CPSF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56669 CHERP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 6.39113 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.060973 GTEX-S32W-0626-SM-2XCBG GTEx Tissue Sample Gene Expression Profiles 1.0 0.836835 GTEX-R53T-0008-SM-48FEW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OTUB2 Pathway Commons Protein-Protein Interactions 1.0 null H3K9me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Myopathy DisGeNET Gene-Disease Associations 1.0 null GTEX-QLQ7-0526-SM-2I5G3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.95795 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of ITTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00853 GSE154074_2_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE157904_3_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC7780220-12943_2020_1301_MOESM8_ESM.xlsx-Fig_3A_RNA-seq_DEGs-Summary_701_LPS-induced_DEGs_361_THZ1-sensitive_DEGs_in_blue_of_macrophages_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18202 GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles 1.0 1.27242 abnormal cardiomyocyte apoptosis MPO Gene-Phenotype Associations 1.0 null KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88392 GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16086 dorsal juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.21831 superficial stratum of r3BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31966 GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE122215,GSE122217_5_v_1_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-XPVG-0726-SM-4B658 GTEx Tissue Sample Gene Expression Profiles 1.0 0.842885 Myoblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.888 JPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02358 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles 1.0 1.30243 H3K9me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7238-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XGQ4-0526-SM-4AT6C GTEx Tissue Sample Gene Expression Profiles 1.0 0.824494 rbm15_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -1.14287 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.953585 H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Biceps brachii TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.869 Primary somatosensory area, upper limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28132 HPAFII DepMap CRISPR Gene Dependency 1.0 2.12429 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.46993 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles 1.0 1.55951 HMY1 DepMap CRISPR Gene Dependency 1.0 2.82811 Dorsomedial nucleus of the hypothalamus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12402 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.65 TTC39C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46989 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.955086 RPL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26927 MD-17-VD78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.292147 GSE195559_8_v_4_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.65695 GTEX-TMMY-1326-SM-4DXU9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 core of P-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05484 cardiac hypertrophy MPO Gene-Phenotype Associations 1.0 null MDAMB415 CCLE Cell Line Gene CNV Profiles -1.0 -1.82836 KAT2B ENCODE Transcription Factor Targets 1.0 null H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null neoplasm GWASdb SNP-Phenotype Associations 1.0 0.045735 HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17399 Lung squamous cell carcinoma_LUSC_TCGA-60-2706-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE164874_5_v_4_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Skeletal system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Restrictive cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.168 mantle zone of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21106 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-0011-R11A-SM-32QPC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.76611 orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.842014 GTEX-U3ZN-1426-SM-3DB87 GTEx Tissue Sample Gene Expression Profiles 1.0 0.929854 JUN JASPAR Predicted Transcription Factor Targets 1.0 null PRRG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1546 hsa-miR-548n TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 103.723 NOL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31852 CFPAC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Eye-retinal ganglion cell Tabula Sapiens Gene-Cell Associations 1.0 -0.135248 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null GTEX-S341-0526-SM-4AD5U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891248 Limb TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.312 GTEX-QEG5-0926-SM-2TC64 GTEx Tissue Sample Gene Expression Profiles 1.0 0.829974 NALM16 DepMap CRISPR Gene Dependency 1.0 4.09016 SPATC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19824 CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LN-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE134375_6_v_5_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PWN1-0008-SM-48TEA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05116 PSMA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44909 Disease of metabolism DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.638 FB-62-KB87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.226605 HCC1806 CCLE Cell Line Gene CNV Profiles 1.0 3.25896 Hyperglycemia CTD Gene-Disease Associations 1.0 1.21011 forelimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.104138 primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.938987 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.08815 signal transduction GO Biological Process Annotations 2015 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPL14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85007 cerebellar vermis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17708 hsa-miR-3119 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 OGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35072 GATA4-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-UPK5-0326-SM-3GAF3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.935242 Brain Lower Grade Glioma_LGG_TCGA-S9-A6TV-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VPS4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96794 periventricular stratum of JcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75539 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39726 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cuneus, left, peristriate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.865168 hematological neoplasm GWASdb SNP-Phenotype Associations 1.0 0.157998 YAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5319 r5 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.95892 Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36312 PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8 Rummagene Transcription Factor Associations 2026 1.0 null KC-36-DK23_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.252685 Myofibrillar myopathy 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.009 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.940295 GSE138863_2_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null DNAJA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17312 GSE144453,GSE144454_1_v_0_tfdp1_human RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.56174 GTEX-SIU7-1426-SM-4BRWT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.855107 GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16699 intermediate stratum of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.19496 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XV7Q-2926-SM-4BRUL GTEx Tissue Sample Gene Expression Profiles 1.0 1.09621 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 orbital frontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2096 Gata-4_KO_GDS4782_329_mouse_Adult heart during pressure overload GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE169697,GSE169725_0_v_5_prrx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PRKRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.50796 Entorhinal area, medial part, ventral zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08244 GTEX-QEL4-0926-SM-3GAD1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.998865 Plagl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.7287 Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.547 MAPK3 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC4011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39821 GTEX-QEG4-0426-SM-33HC3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.906975 LS1034 DepMap CRISPR Gene Dependency 1.0 3.2116 GTEX-XMD1-0011-R6A-SM-4AT5K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824235 GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles 1.0 1.19816 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.8301 Posterior parietal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30458 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.80147 H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r4BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42186 Type IA spiral ganglion neuron_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null Ovarian Diseases CTD Gene-Disease Associations 1.0 1.09892 GPN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07985 GSE142630_0_v_2_hiltonol_human RummaGEO Drug Perturbation Signatures 1.0 null HCCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3526 Primary motor area, Layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36427 Cardiomyopathy, Hypertrophic HuGE Navigator Gene-Phenotype Associations 1.0 null MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.99197 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.052802 skeletal system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00176 Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.65667 Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14144 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6222-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.943869 SMAD2/3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.930957 NCIH1623 CCLE Cell Line Gene CNV Profiles 1.0 1.69492 Heart ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.148 NCIH660 CCLE Cell Line Gene CNV Profiles -1.0 -1.49274 Inflammation CTD Gene-Disease Associations 1.0 1.80491 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832679 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20O-01A-21R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skeletal muscle satellite cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.649 Lung adenocarcinoma_LUAD_TCGA-05-4417-01A-22R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the urinary system GWASdb SNP-Phenotype Associations 1.0 1.34836 GSE202134_0_v_1_rbm39_human RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-K7-AAU7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1806 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles 1.0 1.07009 GSE87617_1_v_0_ascl1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE221539_1_v_3_lrrc10_mouse RummaGEO Gene Perturbation Signatures -1.0 null U266B1 CCLE Cell Line Gene CNV Profiles 1.0 1.50699 Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.842915 ZNF296 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51292 substantia nigra reticulata, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01239 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.0768 NAA10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.07309 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.58324 GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.82305 PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null central nucleus of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16129 GTEX-RM2N-0626-SM-48FD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE88819_6_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.341 IMR32 CCLE Cell Line Gene Expression Profiles -1.0 -1.76317 Ansiform lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05876 Myofilament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.882 PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-y_TFEB_KO_LLOMe_VS_WTLLOMe_UP_TFEB Rummagene Transcription Factor Associations 2026 1.0 null GSE48812_7_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles 1.0 1.92085 molecular_function GO Molecular Function Annotations 2015 1.0 null CBC582 (KDM5C) NURSA Protein Complexes 1.0 null Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.7599 spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.02444 cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.24894 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2C_MEF2C Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles 1.0 1.18319 dexamethasone_mus musculus_gpl6105_gse44208 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCIH2081 CCLE Cell Line Gene Expression Profiles -1.0 -2.04999 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RU72-1426-SM-46MUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Abdominal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.226 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Retrosplenial area, lateral agranular part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33514 cardiomyopathy MPO Gene-Phenotype Associations 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-Q2AG-1126-SM-48U1P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Lung adenocarcinoma_LUAD_TCGA-73-4668-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8428-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EFM19 DepMap CRISPR Gene Dependency 1.0 2.33638 FOXA1_OE_GDS4957_10_human_LNCaP prostate cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SUSD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20581 H3K9me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Primary somatosensory area, trunk, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77552 GTEX-PWOO-0526-SM-2S1Q3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.839466 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16219 Liver hepatocellular carcinoma_LIHC_TCGA-EP-A3RK-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nkx-2.5 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.936 Primary motor area, Layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04743 H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WY7C-0526-SM-3NB3D GTEx Tissue Sample Gene Expression Profiles 1.0 0.927587 Nemaline myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.465 microtubule COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles 1.0 1.02037 UCHL1 Pathway Commons Protein-Protein Interactions 1.0 null BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.25311 ut1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.776 KPNYN CCLE Cell Line Gene Expression Profiles 1.0 1.718 BmN4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.671 HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03805 regulation of microtubule depolymerization GO Biological Process Annotations 2025 1.0 null NCIH1395 CCLE Cell Line Gene CNV Profiles 1.0 1.36052 TM6SF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02254 Myofibrillar myopathy 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.198 H4K91ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DA-35-DU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.16648 hsa-miR-4288 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.906714 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles 1.0 1.13318 KNS60 Achilles Cell Line Gene Essentiality Profiles -1.0 -2.56707 Crus 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2618 GTEX-XBEW-0008-SM-4AT3Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.85716 intermediate stratum of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16129 GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles 1.0 1.70556 SK-N-SH Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10731 GTEX-XXEK-1626-SM-4BRUZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 orbital frontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.956078 COLO-783 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WYJK-1026-SM-3NM8W GTEx Tissue Sample Gene Expression Profiles 1.0 1.21826 GSE242290_1_v_11_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-632 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 PANC0403 CCLE Cell Line Gene Expression Profiles -1.0 -2.38381 deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.93446 PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null MMS19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05468 GSE198794_2_v_1_usp18_human RummaGEO Gene Perturbation Signatures 1.0 null EBC1 CCLE Cell Line Gene CNV Profiles 1.0 2.47453 Primary visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92492 GTEX-S7SF-0526-SM-3K2BC GTEx Tissue Sample Gene Expression Profiles 1.0 0.872515 ARID5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06178 GTEX-PWCY-0526-SM-2I3ER GTEx Tissue Sample Gene Expression Profiles 1.0 0.934541 GTEX-XBED-1326-SM-4AT4F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 MDM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10934 ZNF576 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06302 GTEX-RU1J-0326-SM-46MUM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T2IS-1926-SM-4DM74 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 BATF::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.8771 HT55 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.29288 TNNC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52374 SP1 ENCODE Transcription Factor Targets 1.0 null Declive (VI), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28868 USP21 Pathway Commons Protein-Protein Interactions 1.0 null YES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1592 GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles 1.0 1.07594 SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles 1.0 1.55269 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.620529 GTEX-P4QS-0008-SM-48TDY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null WDR5-24793694-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-XUJ4-0626-SM-4BOOO GTEx Tissue Sample Gene Expression Profiles 1.0 0.832538 A673 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.33099 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.23242 primary auditory cortex (core)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.850316 primary auditory cortex (core)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.976012 OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08663 hemorrhage MGI Mouse Phenotype Associations 2023 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5000-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217405_3_v_2_osimertinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null carcass TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.475423 ZFYVE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01415 HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13452 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05605 LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01224 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02768 HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.992708 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.895429 Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 47.0473 19723343-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GTEX-S4Q7-0726-SM-4AD5F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849002 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.876491 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26026 GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Contractile fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.413 PPM1K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13978 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE122215,GSE122217_0_v_4_peg10_mouse RummaGEO Gene Perturbation Signatures 1.0 null oculomotor nucleus, main part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25671 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null OVMANA DepMap CRISPR Gene Dependency 1.0 2.88642 gallbladder HPA Tissue Protein Expression Profiles 1.0 1.04219 Inclusion body myositis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.183 SMC3 ENCODE Transcription Factor Targets 1.0 null BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885086 PPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57542 GTEX-O5YT-0008-SM-4E3IQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826691 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 abnormal muscle fiber morphology MPO Gene-Phenotype Associations 1.0 null dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35974 Leukemia, Adult T Cell_Blood monocyte_GSE10789 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -0.622623 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRK-0826-SM-2HMK7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00722 microtubule cytoskeleton GO Cellular Component Annotations 2023 1.0 null DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.76757 CEBPB ENCODE Transcription Factor Targets 1.0 null KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20491 GSE203072_2_v_3_rpl3l_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE242290_1_v_8_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null Retrosplenial area, lateral agranular part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20328 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5011-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hyperplasia CTD Gene-Disease Associations 1.0 1.78854 PDZD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41217 GTEX-XPVG-0826-SM-4B654 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08718 intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Autosomal recessive limb-girdle muscular dystrophy type 2G DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.668 Cell Transformation, Neoplastic CTD Gene-Disease Associations 1.0 1.19047 Forelimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.352 seedling TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065737 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.117 Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.015 NR4A2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8783 NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.964258 PMC6347712-pnas.1812449116.sd06.xlsx-iPSC_IRF7_48h_rest_RNAExpress-Gene_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles 1.0 1.00497 Sartorius TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.873 GSE135514_8_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null DISP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33411 Crus 1, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37234 697 Achilles Cell Line Gene Essentiality Profiles 1.0 1.42655 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 ARSK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0095 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null Ventromedial hypothalamic nucleus, central part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08918 Perturb_7351_KD_SFPQ_SRP281189 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.44607 KYSE140 CCLE Cell Line Gene Expression Profiles 1.0 3.40799 ERBB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53003 Skeletal muscle neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 MYOG_myocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B6-01A-21R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83W-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152699,GSE152723_3_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures 1.0 null COR-L321 COSMIC Cell Line Gene Mutation Profiles 1.0 null PTPRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12771 GTEX-PLZ5-0626-SM-2I5F8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03548 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RNOR-0008-SM-48FEY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.72762 HCC70 Achilles Cell Line Gene Essentiality Profiles 1.0 1.0218 Primary somatosensory area, trunk, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40628 hsa-miR-3157-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GTEX-QLQW-0726-SM-447AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE133087_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null hsa-miR-4472 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FN-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Twitch muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.778 MRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14409 GTEX-X88G-0326-SM-47JZ4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.76854 Cell surface furrow COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.803 786O Achilles Cell Line Gene Essentiality Profiles -1.0 -1.08529 PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG Rummagene Transcription Factor Associations 2026 1.0 null PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53 Rummagene Transcription Factor Associations 2026 1.0 null parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00847 GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles 1.0 1.54984 Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.23169 striatum_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.954497 GTEX-X5EB-1026-SM-46MVU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USP8 Pathway Commons Protein-Protein Interactions 1.0 null ZFYVE9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03329 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.887834 Opitz GBBB syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.634 GSE113817_0_v_1_bach1_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_690_KO_RORA_ERP111466 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 Atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.032 CHD1 ENCODE Transcription Factor Targets 1.0 null GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles 1.0 1.5481 lingual gyrus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.63821 Edema CTD Gene-Disease Associations 1.0 1.2437 USP5 Pathway Commons Protein-Protein Interactions 1.0 null MDAMB361 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.76539 abnormal behavior MPO Gene-Phenotype Associations 1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 Longitudinal sarcoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.616 SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.943869 GSE121866_0_v_2_six4_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U3ZH-0326-SM-3DB7A GTEx Tissue Sample Gene Expression Profiles 1.0 0.961914 GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles 1.0 1.09705 Semitendinosus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.724 Hindlimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.011 GTEX-O5YV-0226-SM-48TBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169334,GSE169336_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE118939_1_v_0_nras_human RummaGEO Gene Perturbation Signatures 1.0 null striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.86266 PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles 1.0 1.12321 Sarcoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.315 Vertebrate muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 anterior paraventricular nucleus of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02879 GNPDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40994 negative regulation of supramolecular fiber organization GO Biological Process Annotations 2023 1.0 null brownfat BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.868511 GTEX-WFG8-1126-SM-4LVN1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850352 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.941919 NCIH2141 CCLE Cell Line Gene CNV Profiles -1.0 -1.52074 molecular transducer activity GO Molecular Function Annotations 2015 1.0 null SNU1033 DepMap CRISPR Gene Dependency 1.0 2.68265 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.886289 GTEX-X5EB-0008-SM-46MU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82953 MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 HMBOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00807 PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PWOO-1226-SM-48TCO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 OCT4-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null leukocyte disease GWASdb SNP-Disease Associations 1.0 0.307797 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.595 ECGI10 CCLE Cell Line Gene CNV Profiles 1.0 1.70194 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149903_3_v_2_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null Subparafascicular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90393 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17X-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A84O-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.224359 CENPN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27972 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OC314 DepMap CRISPR Gene Dependency 1.0 2.83111 VPS45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99373 HCC2157 CCLE Cell Line Gene CNV Profiles 1.0 1.65434 DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.75587 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Myotonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.203 Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05703 NR2C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7177 Sarcoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.935 Vastus lateralis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.79 OVTOKO DepMap CRISPR Gene Dependency 1.0 2.59737 leukopenia GWASdb SNP-Disease Associations 1.0 0.35858 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40071 496100473_TCx_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16167 GTEX-XQ3S-1326-SM-4BOPQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 CDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2982 FOXA1_OE_GDS4957_144_human_LNCaP prostate cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05996 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-REY6-1026-SM-2TF4Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.903055 GSE100863,GSE100864_3_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null macromolecular complex binding GO Molecular Function Annotations 2015 1.0 null NCIH526 DepMap CRISPR Gene Dependency 1.0 2.04796 GRWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41109 Endomysium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.571 skeletal muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.625465 Extensor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.113 Kidney Chromophobe_KICH_TCGA-KL-8329-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal heart ventricle morphology MPO Gene-Phenotype Associations 1.0 null MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.56661 PCYOX1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09518 SNU475 CCLE Cell Line Gene Expression Profiles 1.0 2.07587 MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE183606_1_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCNA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51545 Lung adenocarcinoma_LUAD_TCGA-69-7974-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles 1.0 1.27969 regulation of organelle organization GO Biological Process Annotations 2015 1.0 null GSE161295_2_v_1_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE105169,GSE105175_0_v_1_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_9637_KO_CHCHD2_SRP212876 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.77646 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4156 TRIM63 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886123 CL11 DepMap CRISPR Gene Dependency 1.0 2.30713 GTEX-QEG5-1426-SM-447AS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86906 CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKN7 CCLE Cell Line Gene CNV Profiles 1.0 1.7243 Leg muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.32 plant vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.631527 zinc ion binding GO Molecular Function Annotations 2023 1.0 null GTEX-T5JW-0926-SM-4DM5K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 tubulin binding GO Molecular Function Annotations 2015 1.0 null cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.619466 Heschl's gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.889537 GTEX-P78B-0426-SM-2I5F5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02147 sublayer 6a of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11356 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.64461 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41O-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE203308_4_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null abnormality of blood and blood-forming tissues GWASdb SNP-Phenotype Associations 1.0 0.081434 H3K27me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11532 hsa-miR-4532 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.49296 GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 cytoskeletal protein binding GO Molecular Function Annotations 2015 1.0 null myocardial fiber degeneration MGI Mouse Phenotype Associations 2023 1.0 null SKBR3 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.858387 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02833 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ATCAY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6336 RAB3A_Mutation - D77G point mutation_GDS2482_702_mouse_Cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08514 negative regulation of microtubule depolymerization GO Biological Process Annotations 2015 1.0 null Paraventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34711 H3K27me3_iPS-20b Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP Rummagene Transcription Factor Associations 2026 1.0 null EMC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22954 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WAOSEL DepMap CRISPR Gene Dependency 1.0 2.96474 GSE168587,GSE168752_3_v_1_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4447 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 SRSF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1475 TGIF MotifMap Predicted Transcription Factor Targets 1.0 null GSE242290_3_v_7_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null GSE152050,GSE152052_1_v_0_arid1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Declive (VI), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09975 UBE2I Pathway Commons Protein-Protein Interactions 1.0 null ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.5689 PAX3_Knock-in_GDS3331_598_mouse_Palatal shelves (E14.5 embryos - palate) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.91094 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.42562 retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01447 USP18 Pathway Commons Protein-Protein Interactions 1.0 null MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4398 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.638 BATF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7504 primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.22039 TEAD4 ChEA Transcription Factor Targets 1.0 null HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19766 COLO677 CCLE Cell Line Gene Expression Profiles -1.0 -1.49178 GSE206226_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null BFTC-909 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26937 GTEX-P4QT-0008-SM-48TDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 NCIH211 CCLE Cell Line Gene CNV Profiles 1.0 1.59482 Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.343 Muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.421 GTEX-P4QS-0426-SM-3NMCQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824242 GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22041 DV90 CCLE Cell Line Gene Expression Profiles 1.0 1.5564 abnormal locomotor behavior MPO Gene-Phenotype Associations 1.0 null YY1-22570637-MALME-3M-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal cardiovascular system morphology MPO Gene-Phenotype Associations 1.0 null Posterolateral visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33623 GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859342 Hamstring muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.1 Anterolateral visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71029 counterpart GeneRIF Biological Term Annotations 1.0 null NCIH1793 CCLE Cell Line Gene Expression Profiles 1.0 1.37307 NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.921559 FOXP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20768 zinc ion binding GO Molecular Function Annotations 2025 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 skeletalmuscle BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 LB-04-KP05_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.216779 Proteasome regulatory particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.887 RAB3A_KO_GDS2482_706_mouse_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE239844_6_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null abnormality of cardiovascular system physiology GWASdb SNP-Phenotype Associations 1.0 0.102311 Myotome TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.134 Nr2f6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 50.9079 Carbohydrate metabolic disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.638 Formate dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.156 CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03619 GSE130081,GSE130082_0_v_1_neil2_mouse RummaGEO Gene Perturbation Signatures -1.0 null FOS::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4634 GTEX-X4XY-1726-SM-46MVO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.891446 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.58175 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.837 Skeletal muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.794 GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles 1.0 1.25514 STAT1 JASPAR Predicted Transcription Factor Targets 1.0 null mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07559 adrenal gland GTEx Tissue Gene Expression Profiles 1.0 0.828834 GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles 1.0 1.3634 plant form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061643 stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073016 EMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2273 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Ubiquitin activating enzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.065 F8A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54782 cerebralcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.25432 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.5443 Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.961316 A-431 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.29207 Lung adenocarcinoma_LUAD_TCGA-05-4434-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37404 CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PODXL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43902 Anterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52378 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Infertility, Male CTD Gene-Disease Associations 1.0 1.17794 NCI-H2347 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.58636 Weight Loss CTD Gene-Disease Associations 1.0 1.43727 GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.28789 GSE149880_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.15355 GSE203308_7_v_0_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.124 NCIH69 CCLE Cell Line Gene CNV Profiles -1.0 -1.7171 HDAC1 ENCODE Transcription Factor Targets 1.0 null LN428 CCLE Cell Line Gene Expression Profiles 1.0 1.92107 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.876402 GTEX-UJMC-0526-SM-3GAE3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05719 GSE128844_0_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null L1236 DepMap CRISPR Gene Dependency 1.0 2.70916 GTEX-SIU7-0426-SM-2XCDX GTEx Tissue Sample Gene Expression Profiles 1.0 1.00582 Dorsomedial nucleus of the hypothalamus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43981 GSE178714_5_v_4_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19232 whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054122 Skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.463 SKNO1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.0054 GSE203308_14_v_0_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PECAPJ34CLONEC12 CCLE Cell Line Gene Expression Profiles -1.0 -2.36865 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 anterior tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04891 GSE146982_4_v_6_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE92965_0_v_1_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null EIF4A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98056 dilated cardiomyopathy MGI Mouse Phenotype Associations 2023 1.0 null GSE216273,GSE216292_14_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null TUBGCP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10734 H3K27me3_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC6 ENCODE Transcription Factor Targets 1.0 null GTEX-NL3G-0008-SM-4E3JX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EE-08-SZ54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.311991 Perturb_13855_KD_IGF2BP1_SRP284043 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.24476 SKNO1 DepMap CRISPR Gene Dependency 1.0 2.28734 GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 z disc COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.324951 HEYA8 DepMap CRISPR Gene Dependency 1.0 3.28294 GTEX-PWCY-0926-SM-48TD7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 lethargy MPO Gene-Phenotype Associations 1.0 null PAK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00565 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.869735 HT144 DepMap CRISPR Gene Dependency 1.0 2.28037 cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.903209 gata4_16914500_e9dot5_atrioventricular_canal_lof_mouse_gpl1261_gds3663 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.127939 Perturb_7877_KD_NFYB_SRP264849 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 PMC9942993-pone.0281645.s002.xlsx-AR-as_all-ENSEMBL_AR Rummagene Transcription Factor Associations 2026 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QF-01A-31R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 2 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34954 GTEX-UPK5-1126-SM-3GAEJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.885942 MDAMB436 CCLE Cell Line Gene CNV Profiles -1.0 -1.62018 HCC44 CCLE Cell Line Gene Expression Profiles 1.0 2.22579 frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08463 Rarb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 70.08 CHD2 ENCODE Transcription Factor Targets 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null GSE133087_1_v_2_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-Q2AH-0826-SM-48TZN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876263 lateral tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13268 UBE2U Pathway Commons Protein-Protein Interactions 1.0 null ventral isthmic part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28627 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hemorrhage MPO Gene-Phenotype Associations 1.0 null H3K27me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Neurogenic Muscular Atrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2566 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.59157 H3K27me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R53T-0926-SM-3GADH GTEx Tissue Sample Gene Expression Profiles 1.0 0.880208 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.992708 GSE145639_7_v_4_adar_human RummaGEO Gene Perturbation Signatures -1.0 null LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45922 Dilated cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.51 GTEX-QEG5-1126-SM-33HC2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851678 NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.920615 increased apoptosis MPO Gene-Phenotype Associations 1.0 null GSE152699,GSE152723_3_v_2_vemurafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X8HC-2826-SM-46MWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 ALL-PO COSMIC Cell Line Gene Mutation Profiles 1.0 null NP2 DepMap CRISPR Gene Dependency 1.0 2.84636 Dense body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.827 periventricular stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47731 caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.08276 Fast muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.774 SK-MEL-24 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.919176 ESC_V6.5_UP_EARLY.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null RBM15_02_143 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.58496 FOS JASPAR Predicted Transcription Factor Targets 1.0 null GSE157904_2_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.47135 dorsolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.944548 GTEX-SNMC-0126-SM-2XCFO GTEx Tissue Sample Gene Expression Profiles 1.0 0.827308 mediodorsal nucleus of thalamus_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.831525 GSE60691_0_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.649 NCIH1650 CCLE Cell Line Gene Expression Profiles -1.0 -1.46706 ATXN3 Pathway Commons Protein-Protein Interactions 1.0 null SZRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87366 PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Tumor_AND_Prognosis_NOT_Scissor_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null FOXO6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.0026 HUWE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36802 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PA-TU-8988S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03619 UBLC1 CCLE Cell Line Gene Expression Profiles -1.0 -2.561 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58021 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053257 MAFK_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUYS-0005-SM-47JZ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-S4Z8-0008-SM-33HAZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836273 ATM_knockout_75_GSE23116 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.31927 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02378 MON DepMap CRISPR Gene Dependency 1.0 2.47478 abnormal voluntary movement MPO Gene-Phenotype Associations 1.0 null ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.1444 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 OPM2 Achilles Cell Line Gene Essentiality Profiles 1.0 1.1727 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.86584 PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null striatum_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00083 GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Thyroid Neoplasms CTD Gene-Disease Associations 1.0 1.07696 GSE239844_4_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.927676 Skeletal muscle myofibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.913 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE92364_0_v_3_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null i band COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.292897 CKM Pathway Commons Protein-Protein Interactions 1.0 null COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.24996 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01272 single-organism developmental process GO Biological Process Annotations 2015 1.0 null HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE147613_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35502 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04733 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles 1.0 1.23665 contractile fiber part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.611625 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Quadriceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.053 PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100367_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.12739 GTEX-QDT8-0008-SM-48U2F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE217405_3_v_2_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null z disc GO Cellular Component Annotations 2015 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QESD-0008-SM-447B2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 ATXN7 Pathway Commons Protein-Protein Interactions 1.0 null PCMTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35142 mRNA_OTX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null lung BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.2678 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.751 Cytoskeleton in muscle cells KEGG Pathways 2026 1.0 null Anteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.23371 hsa-miR-4800-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 hsa-miR-4747-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 FBXL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22891 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.76757 Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.517 Procyclic form TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.99 Proteasome complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.241 NR3C1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE230744,GSE237803_5_v_3_hira_human RummaGEO Gene Perturbation Signatures -1.0 null GSE184210_0_v_2_glucagon_mouse RummaGEO Drug Perturbation Signatures 1.0 null SMPDL3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35245 CUL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06408 GTEX-S7SF-1426-SM-4AT5A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Central linear nucleus raphe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22768 Z granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.59 heart_6b HPA Tissue Sample Gene Expression Profiles 1.0 1.02546 Basolateral amygdalar nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11701 FOXE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03957 GTEX-X4XX-0626-SM-3NMC1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37104 arthritis GWASdb SNP-Disease Associations 1.0 0.420716 NCIH661 CCLE Cell Line Gene Expression Profiles -1.0 -1.80197 SNU-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.875788 Arthritis DisGeNET Gene-Disease Associations 1.0 null Rhabdomyocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.661 H3K27me3_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JC-06-ED36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.04344 pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30438 Distal arthrogryposis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.18 lymphoma GWASdb SNP-Disease Associations 1.0 0.619466 CTCF-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-R55D-1226-SM-48FE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.248 BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null leukemia GWASdb SNP-Disease Associations 1.0 0.619466 negative regulation of protein complex disassembly GO Biological Process Annotations 2015 1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null periventricular stratum of isBL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30162 RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1 Type 2 diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.329 ZNF75A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.70179 GSE210682_0_v_3_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null planum polare, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.971869 JJ012 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10546 GTEX-WFJO-1026-SM-3GIKL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 NPAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35045 GTEX-QLQ7-0008-SM-447AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25607 FOS::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.4229 COMMD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30149 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.57945 MERO82 DepMap CRISPR Gene Dependency 1.0 2.07337 SNU61 CCLE Cell Line Gene CNV Profiles -1.0 -1.32988 cellular process GO Biological Process Annotations 2015 1.0 null HCC1569 CCLE Cell Line Gene CNV Profiles 1.0 2.42743 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YW-0326-SM-2I5EI GTEx Tissue Sample Gene Expression Profiles 1.0 0.934811 GSE126621,GSE126920_1_v_0_dppa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leg TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.056 disease of cellular proliferation GWASdb SNP-Disease Associations 1.0 0.057021 Dorsomedial nucleus of the hypothalamus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47101 TEAD4 ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH747 DepMap CRISPR Gene Dependency 1.0 2.51162 intracellular organelle part GO Cellular Component Annotations 2015 1.0 null Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null metal ion binding GO Molecular Function Annotations 2015 1.0 null Thorax muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.684 frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29281 Orbital area, ventrolateral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25675 GTEX-R55G-1026-SM-48FDI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26721 USP33 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-N7MT-0011-R2a-SM-2I3GI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 USP15 Pathway Commons Protein-Protein Interactions 1.0 null E2F1-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.1734 biological_process GO Biological Process Annotations 2015 1.0 null PMC11696763-41598_2024_79298_MOESM7_ESM.csv--Table_S1_Differentially_expressed_genes_including_ZNF560_were_screened_out_between_normal_and_tumor_tissues_ZNF560 Rummagene Transcription Factor Associations 2026 1.0 null Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16039 GTEX-WFG8-0926-SM-3GIKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.171 HCC15 DepMap CRISPR Gene Dependency 1.0 2.32998 abnormal blood circulation MPO Gene-Phenotype Associations 1.0 null NCIH2029 CCLE Cell Line Gene Expression Profiles 1.0 1.49498 Primary visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0628 GSE215314_0_v_1_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22374 GSE140997_10_v_1_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2724-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE164874_5_v_12_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null NR4A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9213 GTEX-T5JW-1326-SM-4DM5G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles 1.0 1.13138 abnormal muscle morphology MPO Gene-Phenotype Associations 1.0 null GTEX-XXEK-0526-SM-4BRWD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 TCF7L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9117 regulation of microtubule cytoskeleton organization GO Biological Process Annotations 2015 1.0 null GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles 1.0 1.27613 SOX2_Deficiency_GDS4853_321_human_AZ-521 gastric cancer (GC) cell line - 18 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Dorsal nucleus raphe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4394 GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles 1.0 2.04916 GTEX-QCQG-0426-SM-48U29 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849362 GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 cellular_component GO Cellular Component Annotations 2015 1.0 null GTEX-N7MS-0826-SM-2HML4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.851436 GOLPH3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02329 GSE241036_0_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 GTEX-XUZC-1726-SM-4BRWS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 abnormal cardiac muscle tissue morphology MPO Gene-Phenotype Associations 1.0 null Anteroventral periventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29878 PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Gene_Name_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18922 HCC202 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.8363 SK-N-DZ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01094 liver GTEx Tissue Gene Expression Profiles -1.0 -1.21783 EBNA2-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null microtubule associated complex GO Cellular Component Annotations 2015 1.0 null Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.194 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.557 GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles 1.0 1.21915 TYKNU Achilles Cell Line Gene Essentiality Profiles 1.0 1.07736 magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.902222 NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08689 PPHLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60119 ARHGAP33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63064 Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0731 mRNA_POU5F1_20526341 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27539 GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles 1.0 1.24681 GTEX-SNOS-1426-SM-32PLY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.939018 posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.018 Intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Growth Disorders CTD Gene-Disease Associations 1.0 1.09262 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.35587 GTEX-XUW1-0826-SM-4BOP6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.51285 superficial stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01723 nucleus of the stria terminalis, medial division, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03248 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null FOXN3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4589 Myosin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.26 MYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7944 PPIL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63774 GSE226114,GSE226116_2_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null REC1 CCLE Cell Line Gene CNV Profiles 1.0 1.88259 Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00632 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7091-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus incertus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18082 KALS1 CCLE Cell Line Gene CNV Profiles -1.0 -1.39521 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1306 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE101767_1_v_0_wdr11_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF677 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.8608 TYMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.68373 p1 portion of the paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01695 GTEX-SNMC-0626-SM-4DM6H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 CDK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97479 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles 1.0 1.48733 GTEX-P4PQ-0726-SM-3NMCR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843212 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.97426 cancer GWASdb SNP-Disease Associations 1.0 0.058325 PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null JUN-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TCCSUP CCLE Cell Line Gene CNV Profiles -1.0 -1.35285 NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.56553 NCIH2228 CCLE Cell Line Gene CNV Profiles -1.0 -2.48915 GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles 1.0 1.30767 RPL30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38296 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 oval paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08459 GSE146962_0_v_1_glucosamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-WHWD-1826-SM-3LK6I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857289 SF3A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09014 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A Rummagene Transcription Factor Associations 2026 1.0 null Perturb_8834_KO_MESP1_SRP345831 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Lung adenocarcinoma_LUAD_TCGA-44-7670-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE224311_3_v_2_chaetocin_human RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary hematopoietic stem cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.82885 H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CARF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12827 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28981 CASKIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29922 striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09875 GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles 1.0 1.20482 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CKM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.308 GSE48812_11_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GSE100863,GSE100864_2_v_1_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ATP6V1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01888 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.85722 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null increased cardiomyocyte apoptosis MPO Gene-Phenotype Associations 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6968-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYOD1_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPA-26348894-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null OTUB1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OXRN-1326-SM-3LK5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.67885 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13417 Anxiety Disorders CTD Gene-Disease Associations 1.0 1.04201 Perturb_9483_KO_Fnip1_SRP339469 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.96262 I band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.378 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urophysis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.536 GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles 1.0 1.10327 Skeletal muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.435 cerebellum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.853089 PMC3694431__F5 PFOCR Pathway Figure Associations 2024 1.0 null GSE224096_2_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null Polymeric cytoskeletal fiber COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GSE235701,GSE261434_0_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles 1.0 1.09364 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.972713 GSE144796_1_v_0_linagliptin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE199660_1_v_0_secretin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Autosomal recessive limb-girdle muscular dystrophy type 2H DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.415 HT144SKINFV1 DepMap CRISPR Gene Dependency 1.0 2.92374 RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.976096 JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.940295 ADAMTS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1421 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MC-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHL1DM DepMap CRISPR Gene Dependency 1.0 4.19021 GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE186440,GSE186443_0_v_5_daxx_human RummaGEO Gene Perturbation Signatures -1.0 null polymyxin b sulfate_escherichia coli_gpl3154_gse31140 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of m2AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31827 Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J5-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF Rummagene Transcription Factor Associations 2026 1.0 null GSE210476_2_v_1_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null Infertility, Female CTD Gene-Disease Associations 1.0 1.15324 GTEX-WHWD-0426-SM-3LK83 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01045 testis HPA Tissue Protein Expression Profiles 1.0 0.775428 morphine_mus musculus_gpl6105_gds3703 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lateral hypothalamic area, tuberal part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899366 Intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 MXI1 ENCODE Transcription Factor Targets 1.0 null FOXP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1702 Anteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79351 COX4I1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65497 GTEX-Q2AH-0426-SM-2I3EP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865111 GSE197257_0_v_1_gpd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-654-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41905 MCF12A Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.750284 icSARS CoV_12Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.638454 Perturb_6423_KD_LOC646329_SRP220725 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.99181 GTEX-S32W-0926-SM-4AD5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-QEL4-0008-SM-447AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 plant embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065737 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.850257 abnormal locomotor activation MPO Gene-Phenotype Associations 1.0 null Lobules IV-V, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0093 Perturb_15390_KD_E2F1_SRP399677 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.45991 EPOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02366 Liver Diseases CTD Gene-Disease Associations 1.0 1.61037 EIF3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38959 GSE113817_2_v_1_bach1_human RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-64-5779-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles 1.0 1.29211 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865111 B4GALT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04598 hsa-miR-885-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 MAFG_02_189 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.65208 GSE135400_1_v_0_kdm1b_mouse RummaGEO Gene Perturbation Signatures 1.0 null PcPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.06294 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 Perturb_9639_KO_CHCHD2_SRP212886 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.26945 primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14169 abnormal apoptosis MPO Gene-Phenotype Associations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-YA-A8S7-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles 1.0 1.68138 GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865334 STAM Pathway Commons Protein-Protein Interactions 1.0 null YOD1 Pathway Commons Protein-Protein Interactions 1.0 null Sarcoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.479 Kidney - Cortex GTEx Tissue Gene Expression Profiles 2023 1.0 2.62638 PMC5945521-oncotarget-09-20323-s002.docx-0-MYCN_High_and_p53_High_Downregulated_genes_MYCN Rummagene Transcription Factor Associations 2026 1.0 null limb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.094346 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.858825 A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.996598 H4K20me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUW1-0008-SM-4BOQH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 myoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.344818 GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856931 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.844908 triclosan_staphylococcus aureus_gpl1339_gds3136 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XPVG-2526-SM-4B66D GTEx Tissue Sample Gene Expression Profiles 1.0 1.39112 MYOD1 ENCODE Transcription Factor Targets 1.0 null SNU46 CCLE Cell Line Gene Expression Profiles -1.0 -1.51753 DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null AB-09-EA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.817526 FBXL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05724 Aortic valve stenosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.049 OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66888 muscle fibre TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.240216 MAPK8IP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87781 Muscle fibre TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.244 inferior occipital gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.887702 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217156_2_v_3_trpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE164874_5_v_9_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Nervous System Diseases CTD Gene-Disease Associations 1.0 1.07911 GSE210662_3_v_1_znf165_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5843 H2AFZ ENCODE Transcription Factor Targets 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.34365 CML-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null NVL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16408 LYRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42001 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKNBE2 CCLE Cell Line Gene CNV Profiles 1.0 1.47103 GSE92965_0_v_1_klf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE80098,GSE80366_0_v_8_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles 1.0 1.54413 BL2158 (USP34) NURSA Protein Complexes 1.0 null GSE116930,GSE116935_1_v_6_hes7_human RummaGEO Gene Perturbation Signatures 1.0 null GSE44157,GSE44163_3_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ACVR2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36022 NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32511 GTEX-S4Q7-0626-SM-4AD5M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.887456 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06401 GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles 1.0 1.05848 WDR20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04808 GSE128844_0_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null abnormal heart size MPO Gene-Phenotype Associations 1.0 null mantle zone of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.19551 GTEX-O5YV-0326-SM-2I5H2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.861576 GTEX-P4QR-0726-SM-2I5GO GTEx Tissue Sample Gene Expression Profiles 1.0 0.962487 UBLC1 DepMap CRISPR Gene Dependency 1.0 2.07281 LAMA84 Achilles Cell Line Gene Essentiality Profiles 1.0 1.58019 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CX-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hemochromatosis type 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 H3K27me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD2BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24425 GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.51021 GTEX-WFG7-1626-SM-4LVMF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 primary auditory cortex (core)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0128 SNU16 CCLE Cell Line Gene Expression Profiles 1.0 1.61975 G124 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.864883 Myofibrillar myopathy 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.547 inferior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.91803 Microtubule cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 cuneus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.66911 SRF JASPAR Predicted Transcription Factor Targets 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.051 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EE-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3915 COLO 800 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.941896 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.876491 Simple lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56475 Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.507 OVMANA CCLE Cell Line Gene CNV Profiles 1.0 1.4508 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 2.01814 skin HPA Tissue Gene Expression Profiles -1.0 -1.34667 GTEX-QDVN-0326-SM-2I3FS GTEx Tissue Sample Gene Expression Profiles 1.0 1.03054 Intrinsic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.883 GTEX-U8XE-1726-SM-4E3IF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 EW8 CCLE Cell Line Gene Expression Profiles 1.0 1.49782 LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null Fasting Blood Glucose Measurement DisGeNET Gene-Phenotype Associations 1.0 null H3K27me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59012 GTEX-PSDG-0926-SM-2I5FP GTEx Tissue Sample Gene Expression Profiles 1.0 1.10028 GSE232218_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Posterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05569 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.312 GTEX-U3ZN-0926-SM-4DXTU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853975 Superior colliculus, motor related, intermediate gray layer, sublayer c Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04299 LAMA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70862 MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.79697 leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068266 BRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50104 GTEX-PSDG-1626-SM-48TCQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Longissimus thoracis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.919 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16516 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.919695 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Precommissural nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07231 signal transducer activity GO Molecular Function Annotations 2015 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.61985 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00254 Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A6GE-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15993 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.13762 EBC1 DepMap CRISPR Gene Dependency 1.0 5.33625 Flexor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.089 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229102_1_v_0_nr2f6_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE203308_1_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T6MO-0726-SM-4DM58 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 regulation of protein depolymerization GO Biological Process Annotations 2015 1.0 null PC-62-AQ92_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.212667 RCC-FG2 COSMIC Cell Line Gene Mutation Profiles 1.0 null BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.9686 YY1 ChEA Transcription Factor Targets 1.0 null GSE125219,GSE125221_4_v_8_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null NCIH2087 CCLE Cell Line Gene Expression Profiles 1.0 1.38673 PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null cardiovascular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 NB69 DepMap CRISPR Gene Dependency 1.0 2.26119 NCSTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08746 S0-EE-WJKI_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.361515 lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.961544 Congenital myopathy 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.455 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16968 mRNA_MYC_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TUHR14TKB CCLE Cell Line Gene Expression Profiles -1.0 -1.53844 R1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.577 ubiquitin protein ligase activity GO Molecular Function Annotations 2023 1.0 null DSEL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3402 BICR56 CCLE Cell Line Gene CNV Profiles -1.0 -2.3767 GSE224004,GSE224005_0_v_8_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null ubiquitin protein ligase activity GO Molecular Function Annotations 2025 1.0 null Colon - Sigmoid GTEx Tissue Gene Expression Profiles 2023 1.0 6.47677 OELE Achilles Cell Line Gene Essentiality Profiles -1.0 -2.29744 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19963 GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 PROKR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66515 PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_DN_NR2F1_ind_DN-NR2F1_Ind_DN_NR2F1 Rummagene Transcription Factor Associations 2026 1.0 null triangular septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1111 MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-X585-0011-R8A-SM-46MUX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null shoot TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060952 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LYPLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70673 MKN45 CCLE Cell Line Gene CNV Profiles -1.0 -2.05171 HS-SULTAN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06646 Muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.433 Gall bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.948 GSE147366_3_v_2_med13_human RummaGEO Gene Perturbation Signatures -1.0 null abnormal sarcomere morphology MGI Mouse Phenotype Associations 2023 1.0 null EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Visual areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29706 DNMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36449 Longissimus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.07 Memory Disorders CTD Gene-Disease Associations 1.0 1.10665 GTEX-U3ZN-2226-SM-3DB88 GTEx Tissue Sample Gene Expression Profiles 1.0 1.91437 MZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26528 GTEX-NPJ8-0226-SM-48TBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 SUIT-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.08643 GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.35945 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain - Substantia nigra GTEx Tissue Gene Expression Profiles 2023 1.0 1.25365 RASA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88146 GTEX-X5EB-1426-SM-46MVW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE221327_4_v_9_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.868669 LE-40-JW92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.405834 Soleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.046 PGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21838 PMC8350019-mmc3.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF Rummagene Transcription Factor Associations 2026 1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.57877 18427120-DataS4 GeneSigDB Published Gene Signatures 1.0 null Slow muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.576 GSE120200,GSE127269_1_v_2_asxl1_human RummaGEO Gene Perturbation Signatures 1.0 null CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.955531 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A4ZW-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE88819_11_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC JASPAR Predicted Transcription Factor Targets 1.0 null rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38703 GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-UTHO-0011-R6A-SM-3GIJW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Medial pretectal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.03625 hsa-miR-4314 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 NUDT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69078 Posterior parietal association areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45389 cation binding GO Molecular Function Annotations 2015 1.0 null THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 67.4796 Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-G5-6233-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COV413B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.23549 mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H2BK12ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Hepatomegaly CTD Gene-Disease Associations 1.0 1.58514 Perturb_17549_KD_STAT3_SRP354633 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Lung Neoplasms CTD Gene-Disease Associations 1.0 1.39366 GTEX-U3ZH-0008-SM-4DXT2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 seed TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063158 Sarcoma_SARC_TCGA-DX-A48K-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null olfactorybulb BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.971632 MROH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16658 UTP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31829 TNPO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66551 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40071 GTEX-WHSE-0011-R6A-SM-3P5ZP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.32976 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.56547 U2AF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0955 Paraventricular nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23073 subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.03316 PMC9942321-12916_2023_2766_MOESM1_ESM.xlsx-S9-Supplementary_Table_9_DEGs_distributed_per_SOM_profile_in_all_IS_etiologies_based_on_Euclidean_distance_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null MYOD1_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lambdoid septal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36755 GSE128730_4_v_2_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null BC-62-RZ55_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.19488 PRUNE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18065 TP53-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870022 H2BK12ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CORL95 CCLE Cell Line Gene Expression Profiles -1.0 -2.22435 Immune System Diseases CTD Gene-Disease Associations 1.0 1.02858 OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215866 PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR Rummagene Transcription Factor Associations 2026 1.0 null Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.227 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-1626-SM-48FEG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Extensor digitorum longus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.732 cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917875 FEM1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62015 MCM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2945 GTEX-T6MN-0926-SM-32PLX GTEx Tissue Sample Gene Expression Profiles 1.0 1.02508 GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08915 GSE48812_2_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles 1.0 1.07231 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gracilis muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.646 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE182179_0_v_4_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null Type 1 diabetes mellitus_Thymic epithelial cell_GSE11 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.11672 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.61993 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39821 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47963 P4HTM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17662 Intramuscular adipose tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.048 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles 1.0 1.52743 Finger TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.366 hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.893236 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRG_ESRRG Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles 1.0 1.19251 negative regulation of protein depolymerization GO Biological Process Annotations 2023 1.0 null HCC202 CCLE Cell Line Gene CNV Profiles 1.0 1.35643 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.025 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.65286 Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 403.55 GSE242290_3_v_10_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y5-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Foot TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.582 Brain Lower Grade Glioma_LGG_TCGA-S9-A7IX-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.658 CUL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10456 core of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61374 Perturb_8073_KD_SNORD126_SRP337208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.49845 Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.06 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.325 H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Retrosplenial area, lateral agranular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28442 GTEX-XV7Q-0126-SM-4BRVK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE252857_2_v_3_klf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cardiac hypertrophy MGI Mouse Phenotype Associations 2023 1.0 null SLC25A46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90095 RAB21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25348 GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles 1.0 0.958943 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16537 Perturb_15860_KD_ETS1_SRP270313 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE241402_0_v_1_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39821 GSE188721_3_v_4_mesp1_human RummaGEO Gene Perturbation Signatures -1.0 null LN215 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.31607 PMC11960529-mmc4.xlsx-Ventricular_ZNF711_KOoverCT-gene_ZNF711 Rummagene Transcription Factor Associations 2026 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LR-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMPD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24738 Fascia adherens COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.639 GSE229468,GSE229471_0_v_3_znf587_human RummaGEO Gene Perturbation Signatures 1.0 null CORL279 CCLE Cell Line Gene Expression Profiles 1.0 2.39913 Kidney renal papillary cell carcinoma_KIRP_TCGA-PJ-A5Z9-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226114,GSE226116_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null hand TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.405176 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03805 Entorhinal area, medial part, ventral zone, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0158 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.05857 GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles 1.0 1.78238 PMC7176284-pcbi.1007753.s008.xlsx-2_MYCN-NA_NBL_Multimodal_Genes-gene_MYCN Rummagene Transcription Factor Associations 2026 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Invertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.989 GSE161295_2_v_5_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null flexor TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.537812 GSE164874_5_v_3_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null AB-18-YN11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.1104 MRPS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53139 heart BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMS11 CCLE Cell Line Gene Expression Profiles -1.0 -1.4656 vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.75247 mammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06121 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.859173 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08663 EZH2 ENCODE Transcription Factor Targets 1.0 null JJ012 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.90198 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TMZS-0008-SM-47JWM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892569 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.077 YY1-22570637-MALME-3M-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.05725 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11227 E2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3622 Perturb_5006_KO_BACH1_SRP143680 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -14.5928 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Biceps femoris TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.595 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45667 GTEX-REY6-1426-SM-48FDK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles 1.0 1.37422 Perturb_8695_KO_Stat1_SRP364338 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 gout GWASdb SNP-Disease Associations 1.0 1.50298 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.947597 regulation of biological process GO Biological Process Annotations 2015 1.0 null H2AC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10255 Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02291 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.11737 GSE125219,GSE125221_5_v_8_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null Striated muscle thin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.769 mRNA_DLX3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-TMMY-0008-SM-4DXU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 lymphoma GWASdb SNP-Phenotype Associations 1.0 0.525969 Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NI-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null GOLGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56673 HMEL CCLE Cell Line Gene Expression Profiles 1.0 1.75248 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1223 NR2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61811 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10346 MYH9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45639 GSE152937_12_v_1_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null Primary somatosensory area, mouth, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12392 hematologic cancer GWASdb SNP-Disease Associations 1.0 0.187684 ANP32A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06849 SMOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59903 Primary motor area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16857 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.49272 Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CALU-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.921559 GTEX-RUSQ-0526-SM-2TF72 GTEx Tissue Sample Gene Expression Profiles 1.0 0.830302 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18764 bone inflammation disease GWASdb SNP-Disease Associations 1.0 0.390332 Muscle-fast muscle cell Tabula Sapiens Gene-Cell Associations 1.0 0.0113507 GCNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27532 ABC1 DepMap CRISPR Gene Dependency 1.0 2.86363 GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles 1.0 1.31832 Intranuclear rod COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.799 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.17988 RAD21 ENCODE Transcription Factor Targets 1.0 null SNU899 CCLE Cell Line Gene Expression Profiles 1.0 1.38055 Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.833246 GTEX-QDVJ-0726-SM-48U1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 HL-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.667 PMC7617265-EMS137094-supplement-Supplementary_Tables.xlsx-ST18-gene_ST18 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.232 Necrosis CTD Gene-Disease Associations 1.0 1.97478 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865111 Microtubule COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10731 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07445 NFYC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03219 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055896 Perturb_15862_KD_KDM3A_SRP270313 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Ikzf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.6991 microtubule GO Cellular Component Annotations 2023 1.0 null Bloodstream form TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.896 BCL3 ENCODE Transcription Factor Targets 1.0 null GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures -1.0 null abnormal sarcomere morphology MPO Gene-Phenotype Associations 1.0 null GSE159893_2_v_1_genistein_human RummaGEO Drug Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.39846 Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.30087 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051066 GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles 1.0 1.42601 NCI-H1048 COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Entorhinal area, medial part, ventral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18632 GSE178907_5_v_3_fkrp_human RummaGEO Gene Perturbation Signatures 1.0 null abnormal heart left ventricle morphology MGI Mouse Phenotype Associations 2023 1.0 null H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.842915 GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48837 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null FBXL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.04517 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12039 microtubule GO Cellular Component Annotations 2025 1.0 null Diabetes mellitus DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.638 IPPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40502 GSE242290_1_v_2_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.35943 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6017-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.62279 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWN1-0726-SM-48TDR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Myofibrillar myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.927 GTEX-V955-2426-SM-3GAEF GTEx Tissue Sample Gene Expression Profiles 1.0 1.29949 CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETCC016 DepMap CRISPR Gene Dependency 1.0 2.26459 GSE224096_1_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null Primary somatosensory area, trunk Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30772 CEBPB JASPAR Predicted Transcription Factor Targets 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.7568 Tibialis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.112 GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826812 Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.461 FOSL1::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9056 Kidney Diseases CTD Gene-Disease Associations 1.0 1.254 Perturb_13570_KD_Islr_SRP160431 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 ntera2 HPA Cell Line Gene Expression Profiles 1.0 1.78846 MAML1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19806 hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30106 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054105 TBK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23034 Lung squamous cell carcinoma_LUSC_TCGA-77-8148-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE198794_2_v_3_usp18_human RummaGEO Gene Perturbation Signatures 1.0 null FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9018 PMC12005766-ADVS-12-2413120-s003.xlsx-VENN1-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_with_the_E3_or_DUB_gene_set_from_the_iUUCD_2_0_database_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_7501_KD_EP300/YAP1_SRP193326 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.55121 STK17A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52815 NCI-H2347 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null FXR MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles 1.0 1.36226 G118 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.59934 single-multicellular organism process GO Biological Process Annotations 2015 1.0 null Right_Atrium Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.27819 GSE248045,GSE248046_6_v_5_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19182 Fields of Forel Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00554 abnormal muscle contractility MPO Gene-Phenotype Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-8200-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.165 GSE178714_1_v_4_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-K1-A6RT-01A-32R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08253 skeletal muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.59782 SRF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8428 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.15318 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28935 SIRT6 ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Peptidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.189 NCIH2052 CCLE Cell Line Gene CNV Profiles 1.0 1.94267 NCIH2347 CCLE Cell Line Gene Expression Profiles 1.0 1.85373 GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 D502MG DepMap CRISPR Gene Dependency 1.0 2.90223 GSE148200_0_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null PMC9942993-pone.0281645.s002.xlsx-AR-as_all-SYMBOL_AR Rummagene Transcription Factor Associations 2026 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 HSPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28655 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.77168 Prostate adenocarcinoma_PRAD_TCGA-HI-7169-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.1103 ACBD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.001 FADU CCLE Cell Line Gene CNV Profiles -1.0 -1.55821 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null regulation of cellular process GO Biological Process Annotations 2015 1.0 null Left ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.148 regulation of microtubule polymerization or depolymerization GO Biological Process Annotations 2015 1.0 null GTEX-OXRL-0326-SM-2I3F2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11822 GTEX-QVJO-0011-R6A-SM-2S1QN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LS 180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.40435 mRNA_NRIP1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles 1.0 0.874926 19235837-TableS2b GeneSigDB Published Gene Signatures 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null r3 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32074 NCI-H2369 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.41423 GSE155031_5_v_3_dextran_human RummaGEO Drug Perturbation Signatures 1.0 null septal nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.993739 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.874429 Fast twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.761 dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.38294 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null bronchial disease GWASdb SNP-Disease Associations 1.0 0.619466 Aortic valve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.075 Phospholamban complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.9 hypertension GWASdb SNP-Phenotype Associations 1.0 0.901186 Uterine cervix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.907616 hypocotyl TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066911 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null sublayer 6a of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26482 Ventral anterior-lateral complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22761 19658189-TableS5 GeneSigDB Published Gene Signatures 1.0 null Hypertension CTD Gene-Disease Associations 1.0 1.15492 ZNF254 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48574 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40876 BGC823 CCLE Cell Line Gene CNV Profiles -1.0 -1.36316 magnocellular superficial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15497 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.991853 CAL 27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33644 Troponin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.757 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17432 GTEX-Q2AH-0526-SM-2I3ED GTEx Tissue Sample Gene Expression Profiles 1.0 1.07816 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.854169 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06646 GTEX-OXRO-1726-SM-3LK6C GTEx Tissue Sample Gene Expression Profiles 1.0 1.11652 CDX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29072 M band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.694 periventricular mantle of isBM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28627 NFYA JASPAR Predicted Transcription Factor Targets 1.0 null PSMB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62225 GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24618 Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q4-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 H3K9me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gastrocnemius TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.185 H4K91ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE188458_2_v_1_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.021 obstructive lung disease GWASdb SNP-Disease Associations 1.0 0.35858 CL-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.97234 muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.53552 SF767 CCLE Cell Line Gene Expression Profiles 1.0 1.55783 vascular disease GWASdb SNP-Disease Associations 1.0 0.09952 PMC8482521-mmc10.xlsx-Upstreme_regulators_12_hr_MLR-Unnamed_0_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null mRNA_MYOD1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3153 CCDC184 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3152 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.909661 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.45389 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-0326-SM-2TF5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.932451 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.919974 SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52951 RPL34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83464 GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles 1.0 1.41343 PSMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2556 nucleus subputaminalis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08382 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.999041 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_12219_KD_EPRS_SRP073504 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.85764 NUP43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5868 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.24619 GSE125014_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Tibialis anterior TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.08 UBE2D3 Pathway Commons Protein-Protein Interactions 1.0 null GSE203308_4_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TCF4 ChEA Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78M-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTDSPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93333 ANKRD27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80227 Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GPALPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28686 muscle GTEx Tissue Gene Expression Profiles 1.0 1.80912 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-11A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of microtubule depolymerization GO Biological Process Annotations 2015 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.368 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205332_1_v_0_queuine_human RummaGEO Drug Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12003 parenchyma TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.511778 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16775 GTEX-WFON-2326-SM-3LK7M GTEx Tissue Sample Gene Expression Profiles 1.0 1.43336 GSE190555,GSE190557_2_v_0_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Satellite cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.718 vertical nucleus of the diagonal band Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21461 FOSL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4395 GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles 1.0 0.981554 GTEX-QDVN-2426-SM-2S1Q4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.982562 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.914434 NR1H4::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.6276 HL60 Achilles Cell Line Gene Essentiality Profiles 1.0 1.36653 RAB2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23895 superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.5849 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles 1.0 0.968075 SKIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88813 estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.28959 TRABD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20095 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-POYW-0526-SM-2XCEY GTEx Tissue Sample Gene Expression Profiles 1.0 0.971658 P68-20966046-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.321 CTCF ENCODE Transcription Factor Targets 1.0 null Ventromedial hypothalamic nucleus, dorsomedial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00289 BRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62633 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36611 GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45641 GTEX-XQ8I-0126-SM-4BOPL GTEx Tissue Sample Gene Expression Profiles 1.0 0.976625 posteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85275 GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles 1.0 1.78704 Cognition Disorders CTD Gene-Disease Associations 1.0 1.12771 INTS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66669 ventrolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.82407 UBE2M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16531 C2C12 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.966 GTEX-R3RS-0008-SM-48FF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875619 NCI-H650 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles 1.0 1.15578 UPCISCC200 DepMap CRISPR Gene Dependency 1.0 3.02131 EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null behavior/neurological phenotype MPO Gene-Phenotype Associations 1.0 null GSE176008_7_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-548k TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 microtubule-based process GO Biological Process Annotations 2015 1.0 null orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.39154 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.99439 superficial stratum of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34711 GSE44157,GSE44163_1_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE216273,GSE216292_0_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null SUPT4H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94423 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Nearest_Ensembl_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.985922 abnormal cell physiology MPO Gene-Phenotype Associations 1.0 null HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09347 GSE213632_4_v_5_acod1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Thigh muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.972 cytoskeletal part GO Cellular Component Annotations 2015 1.0 null PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TKQ2-0926-SM-4DXU5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.37 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.852493 increased cardiomyocyte apoptosis MGI Mouse Phenotype Associations 2023 1.0 null motor nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H4 CCLE Cell Line Gene CNV Profiles -1.0 -1.92703 CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0008-SM-4AT41 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898879 Neurotoxicity Syndromes CTD Gene-Disease Associations 1.0 1.04201 Primary somatosensory area, upper limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1595 GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles 1.0 1.53758 X-linked Emery-Dreifuss muscular dystrophy 6 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.211 Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal heart morphology MGI Mouse Phenotype Associations 2023 1.0 null GTEX-RTLS-0526-SM-2TF64 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32853 PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null Mammary Neoplasms, Animal CTD Gene-Disease Associations 1.0 1.08513 primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.72387 CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829984 PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3571 Sacrospinalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.033 posteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91244 H3K9me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-1026-SM-2TC5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.998108 GTEX-U412-2026-SM-4DXSI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831731 GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles 1.0 1.53789 abnormal heart ventricle wall thickness MPO Gene-Phenotype Associations 1.0 null primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41964 GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21799 titin-telethonin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.345 increased cell death MPO Gene-Phenotype Associations 1.0 null Scd1_DELETION_GDS4910_309_mouse_Skin GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null septohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4002 periventricular stratum of r1BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38135 PPARD_KO_GSE16048_54_mouse_pancreas (islets, PDX1-expressing cells) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null Ciliary neurotrophic factor receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.158 SYNGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12887 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02833 DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.896011 GTEX-V1D1-0003-SM-3NMDP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834292 Left_Ventricle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.37149 FOS ENCODE Transcription Factor Targets 1.0 null TCF4-18268006-LS174T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-1226-SM-4AD67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 PMC5755497__F12 PFOCR Pathway Figure Associations 2024 1.0 null KYSE-270 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Downregulated_NR2F1 Rummagene Transcription Factor Associations 2026 1.0 null EVSA-T COSMIC Cell Line Gene Mutation Profiles 1.0 null KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null negative regulation of protein depolymerization GO Biological Process Annotations 2015 1.0 null GSE165678_0_v_5_stat5a_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R55G-1126-SM-48FDG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Dinoflagellate cingulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.82 TC32 CCLE Cell Line Gene Expression Profiles 1.0 1.96716 PEX14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0835 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-50-FR41_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.519898 PMC5503541-oncotarget-08-38399-s003.docx-1-TCF7L1_TCF7L1 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null GTEX-O5YT-0326-SM-32PKA GTEx Tissue Sample Gene Expression Profiles 1.0 0.84058 GSE123836_2_v_3_myf6_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H2347 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.886289 Small_Intestine-intestinal crypt stem cell Tabula Sapiens Gene-Cell Associations 1.0 0.0213461 GTEX-R55G-0526-SM-2TC5O GTEx Tissue Sample Gene Expression Profiles 1.0 0.864643 HDAC2 ENCODE Transcription Factor Targets 1.0 null HCC44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.995451 HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.973434 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null hsa-miR-4701-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 rostromedial tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10795 NCIH522 DepMap CRISPR Gene Dependency 1.0 2.36496 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-RXRG_RXRG Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WQUQ-1426-SM-3MJFD GTEx Tissue Sample Gene Expression Profiles 1.0 0.991098 JHESOAD1 CCLE Cell Line Gene Expression Profiles 1.0 1.46888 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054755 superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02899 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles 1.0 2.03676 FOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19307 NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.993717 GTEX-XOTO-0011-R5A-SM-4B657 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927477 SELENOM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04264 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.932772 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZDHHC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03774 USP7 Pathway Commons Protein-Protein Interactions 1.0 null striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.9805 abnormal myocardial fiber morphology MPO Gene-Phenotype Associations 1.0 null LS180 CCLE Cell Line Gene Expression Profiles 1.0 1.65804 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QB-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Diaphragm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.61 GTEX-WH7G-1526-SM-4LVMX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846772 Kidney Chromophobe_KICH_TCGA-KL-8326-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886406 Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.342 Carcass TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.036 Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169571_5_v_1_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Autosomal recessive limb-girdle muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.604 cuneus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17077 NR3C1_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventral posterolateral nucleus of the thalamus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23948 GTEX-RWS6-2026-SM-2XCB5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Lung-nk cell Tabula Sapiens Gene-Cell Associations 1.0 -0.141912 OGFOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53453 GTEX-RM2N-0826-SM-48FD3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.339 H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.0244 Perturb_12996_KD_NCOR2_SRP102092 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.06125 cytoskeletal part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 pou5f1_20526341_human_embryonic_stem_cells_hesc_lof_human_gpl6947_gse21135 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.565328 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.970294 Perturb_18394_KO_Ivl_SRP286259 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.3394 Perturb_6339_KO_Des_SRP272249 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.45279 GSE169697,GSE169725_0_v_4_prrx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SIU7-0526-SM-3NM8I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921902 Penis_Foreskin_Keratinocyte_Primary_Cells_skin02 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.76669 LSM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15465 GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles 1.0 0.980537 SURF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08344 dorsal septopreoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80403 GTEX-PWCY-0008-SM-48TE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-OHPM-0326-SM-33HCA GTEx Tissue Sample Gene Expression Profiles 1.0 0.991697 GSE248045,GSE248046_0_v_5_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08944 HDMYZ DepMap CRISPR Gene Dependency 1.0 3.22557 striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.45983 PSS008 DepMap CRISPR Gene Dependency 1.0 3.61846 layer 1 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05065 GTEX-SE5C-0626-SM-2XCDV GTEx Tissue Sample Gene Expression Profiles 1.0 0.902311 posteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.17676 PMC5755497__F12 PFOCR Pathway Figure Associations 2023 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QV44-2026-SM-2S1RD GTEx Tissue Sample Gene Expression Profiles 1.0 1.36221 Perturb_13468_Mut_Ar_SRP045727 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.04362 FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.698 H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FOXP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8903 NF-E2 MotifMap Predicted Transcription Factor Targets 1.0 null E2F1 ChEA Transcription Factor Targets 1.0 null striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10789 GSE217115_2_v_0_alectinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Embryonic structure TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45911 NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.24385 H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles 1.0 1.10704 SCF ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.417 intermediate stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16768 GSE146982_4_v_6_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Intermediodorsal nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10318 Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XBEC-1226-SM-4AT65 GTEx Tissue Sample Gene Expression Profiles 1.0 0.838882 GTEX-V1D1-0526-SM-4JBGW GTEx Tissue Sample Gene Expression Profiles 1.0 0.916542 EXTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33603 H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Left atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.032 ALDH9A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03036 Perturb_776_KD_hsa_circ_0004287_SRP310189 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.3076 GSE237040_2_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of PHyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15586 Neuromuscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.083 GSE213611_1_v_0_nuf2_human RummaGEO Gene Perturbation Signatures 1.0 null PMC3694431__F5 PFOCR Pathway Figure Associations 2023 1.0 null ventral lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1459 GTEX-QLQ7-0826-SM-447B3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.88569 CENPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09777 GTEx BloodVessel 20-29 vs 40-49 GTEx Tissue-Specific Aging Signatures 1.0 7.00733 medial subhabenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06838 Kidney Chromophobe_KICH_TCGA-KN-8434-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUPT5H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.1279 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04336 Parataenial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11842 Perturb_8068_KD_NONO_SRP281189 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 12.8744 limb-girdle muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.804 CDK5RAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89486 ISTMES1 CCLE Cell Line Gene CNV Profiles -1.0 -1.93529 posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.889644 ATXN3L Pathway Commons Protein-Protein Interactions 1.0 null Posterolateral visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09308 muscle phenotype MPO Gene-Phenotype Associations 1.0 null Glucose metabolism disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.638 GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles 1.0 1.1142 PPARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.6579 MICALL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75463 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.032 NANOG ChEA Transcription Factor Targets 1.0 null GTEX-OIZG-1126-SM-2HMIU GTEx Tissue Sample Gene Expression Profiles 1.0 0.930114 posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.850603 Ovarian Neoplasms CTD Gene-Disease Associations 1.0 1.21468 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPL-2526-SM-3MJGT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93374 parvicellular interstitial nucleus of the posterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.87961 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hand TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.365 sc71 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.587 LS 174T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36932 multicellular organismal development GO Biological Process Annotations 2015 1.0 null GSE247775_1_v_0_tmprss2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SLVL DepMap CRISPR Gene Dependency 1.0 2.48456 Perturb_8464_OE_C2_SRP242584 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -18.0506 ZNF324 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1695 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.60683 GTEX-P4PQ-0326-SM-2HMJ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01765 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.337 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.905807 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null m1AD (DM) part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51418 MZ in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45771 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.50943 Brain Lower Grade Glioma_LGG_TCGA-HT-7880-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08114 GTEX-WHPG-0826-SM-3NMBF GTEx Tissue Sample Gene Expression Profiles 1.0 0.91083 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.10162 GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34132 GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles 1.0 1.31439 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.529 GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles 1.0 1.55404 LHX1_NULL MUTATION - Ablation_GDS1748_748_mouse_Embryonic kidneys (from day E14.5) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles 1.0 1.53895 Coronary artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.478 inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66811 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81J-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0093 magnocellular (medial) subparafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8372 SENP3 Pathway Commons Protein-Protein Interactions 1.0 null NR3C1 JASPAR Predicted Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4837-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12789432-41467_2025_66251_MOESM4_ESM.csv--SOX2_tumorigenesis_signature_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE185519_3_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null C15orf39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12346 KIF20A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53773 Entorhinal area, medial part, ventral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09446 Creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.636 Perturb_15613_Mut_Dmd_SRP329695 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.22337 MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.927676 r4 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4414 Myositis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.167 bff3 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.979 macromolecular complex GO Cellular Component Annotations 2015 1.0 null GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE195559_6_v_4_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null DOK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.993152 cellular phenotype MPO Gene-Phenotype Associations 1.0 null DHCR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52966 skin GTEx Tissue Gene Expression Profiles -1.0 -0.87287 GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08549 EVSAT CCLE Cell Line Gene CNV Profiles -1.0 -1.32536 GTEX-WL46-0926-SM-3LK7T GTEx Tissue Sample Gene Expression Profiles 1.0 0.872696 GTEX-QDVJ-0426-SM-2I5FW GTEx Tissue Sample Gene Expression Profiles 1.0 1.22582 hsa-miR-541 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Endopeptidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.213 Retrosplenial area, lateral agranular part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29922 GSE88819_5_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EBNA2-21746931-IB4-LCL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GA-10 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QDVJ-0826-SM-48U1S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.78561 Sarcoglycan complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.962 ZNF184 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.7775 Congenital myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.957 cell differentiation GO Biological Process Annotations 2015 1.0 null callosal sling Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3041 GSE241701_1_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null WERIRB1 DepMap CRISPR Gene Dependency 1.0 2.41707 muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.693719 Fasting Blood Sugar Result DisGeNET Gene-Phenotype Associations 1.0 null GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32511 HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.912495 18614019-TableS4c GeneSigDB Published Gene Signatures 1.0 null developmental process GO Biological Process Annotations 2015 1.0 null GTEX-U8XE-1126-SM-3DB8W GTEx Tissue Sample Gene Expression Profiles 1.0 0.860665 GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles 1.0 1.29276 ERVMER34-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07006 TBP ENCODE Transcription Factor Targets 1.0 null GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles 1.0 1.21034 Primary visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50603 S100PBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06672 outer CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45026 periventricular stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.06197 GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles 1.0 1.30229 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.348 heart TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060086 Heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.767 Muscle-slow muscle cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0219673 GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 abnormal myocardial fiber physiology MPO Gene-Phenotype Associations 1.0 null medial part of MPO Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51377 PMC8390644-41467_2021_25107_MOESM6_ESM.xlsx-Primed_BRG1-KD_significant-gene_AR Rummagene Transcription Factor Associations 2026 1.0 null FLOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11916 FLNC Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZCCHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49457 DFCI024 CCLE Cell Line Gene Expression Profiles 1.0 1.40575 Sarcoma_SARC_TCGA-IW-A3M6-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4407272-elife06857s001.xls-MITF_partners_SNF-MITF_partners_MITF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QV31-1326-SM-2S1QE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87447 MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PTBP1_02_07 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.58496 Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null negative regulation of organelle organization GO Biological Process Annotations 2015 1.0 null Organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GSE162575,GSE162609_3_v_2_tfe3_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XUZC-1826-SM-4BRVO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62918 TCF4-18268006-LS174T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05075 cAMP-dependent protein kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.769 GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles 1.0 1.61132 SNRPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23911 GTEX-SUCS-0008-SM-4DM53 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.9466 KDM4A ENCODE Transcription Factor Targets 1.0 null BRIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79572 FOSL1::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0225 negative regulation of microtubule depolymerization GO Biological Process Annotations 2023 1.0 null GTEX-WFON-0326-SM-3GIKX GTEx Tissue Sample Gene Expression Profiles 1.0 0.903974 GTEX-QV44-1026-SM-447CG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles 1.0 1.07239 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.05324 RRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39063 ZNF763 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12337 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4338-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SR786 CCLE Cell Line Gene Expression Profiles -1.0 -1.59708 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-0826-SM-4DM5N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872072 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T5JW-0226-SM-4DM7I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Psoas_Muscle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.6021 Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 TCF12_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQ7-0926-SM-447BC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935297 FOXO4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3723 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.55315 FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Simple lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59012 polymeric cytoskeletal fiber GO Cellular Component Annotations 2025 1.0 null arm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.351856 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles 1.0 1.51416 Lung squamous cell carcinoma_LUSC_TCGA-77-6843-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDC37L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82286 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5892-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular part GO Cellular Component Annotations 2015 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NAMALWA COSMIC Cell Line Gene Mutation Profiles 1.0 null myotube TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.765711 H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null negative regulation of protein depolymerization GO Biological Process Annotations 2025 1.0 null GSE123372,GSE123373_1_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R55G-0926-SM-48FDN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 ESS1 CCLE Cell Line Gene Expression Profiles -1.0 -2.53506 19658189-TableS3 GeneSigDB Published Gene Signatures 1.0 null GTEX-PWOO-0008-SM-48TDU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4EP-0526-SM-3P5YW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.00501 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21847 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.42446 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049139 H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Distal myopathy 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.414 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.45193 Acute myocardial infarction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.25 MRK-NU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA Rummagene Transcription Factor Associations 2026 1.0 null NGFRAP1 Hub Proteins Protein-Protein Interactions 1.0 null primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.38235 H2BK20ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.891677 Depressive Disorder CTD Gene-Disease Associations 1.0 1.21435 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.14763 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.21504 LTO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98812 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-11A-01R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.47012 GTEX-X4XY-0008-SM-46MVL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 HUPT4 DepMap CRISPR Gene Dependency 1.0 2.6952 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.12297 AC-30-XU83_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.41477 substantianigra BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.65598 Chronic obstructive pulmonary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.437 H3K4me1_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ATF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77723 Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.507 CTNND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52557 negative regulation of microtubule depolymerization GO Biological Process Annotations 2025 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3316-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32954 SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1915 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 ubiquitin-protein transferase activity GO Molecular Function Annotations 2023 1.0 null CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-XXEK-0008-SM-4BRW7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 ERAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26539 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11694 TM9SF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3863 Kinetoplastid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.267 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.29207 MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Supramolecular fiber COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles 1.0 1.30317 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 CEBPD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.736 Adrenocortical carcinoma_ACC_TCGA-OR-A5LK-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hedgehog signaling complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.703 H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-0008-SM-48FEX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.58175 Nr5a1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.9796 ZNF511 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66951 Heart valve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.109 posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38652 EW-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null prostate_a HPA Tissue Sample Gene Expression Profiles 1.0 0.877897 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78K-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WOFL-0626-SM-3MJG3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.880986 TRIP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56558 GSE161295_4_v_3_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null DIFI DepMap CRISPR Gene Dependency 1.0 2.71464 layer 3 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41465 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.86996 GSE239844_6_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null JOSD1 Pathway Commons Protein-Protein Interactions 1.0 null FOS::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.427 PPAR-Beta_DELETION_GDS4320_363_mouse_Pancreatic beta-cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hsa-miR-4520a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 skeletal muscle HPA Tissue Protein Expression Profiles 1.0 1.04219 regulation of cytoskeleton organization GO Biological Process Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Z-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null heart_6a HPA Tissue Sample Gene Expression Profiles 1.0 1.00329 GSE125862_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06271 Perturb_14754_OE_SLC28A3AS1_SRP303692 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -16.7683 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5094-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.41423 PANC1005 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.35894 FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.305 F-actin capping protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.801 SMG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12404 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5097-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null transition metal ion binding GO Molecular Function Annotations 2023 1.0 null CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.58549 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 H3K27me3_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Striated muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.833 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30729 GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 ventromedial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10206 GSE152055_2_v_3_mpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GA-16-IU17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221539 NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52043 GSE157383_3_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null ASCC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00058 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.983984 protein modification by small protein conjugation GO Biological Process Annotations 2023 1.0 null GTEX-U3ZH-1126-SM-4DXUG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.436 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.56184 trochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19937 UT7 CCLE Cell Line Gene CNV Profiles -1.0 -2.22404 Loin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.796 THOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.65145 H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37838 MACROH2A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27284 CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-1026-SM-48FCM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 mammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05959 GTEX-NPJ8-0426-SM-2HMK6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.904389 496100633_TCx_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13997 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056859 mouse GeneRIF Biological Term Annotations 1.0 null RORA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.3033 URI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63047 EMTOKA DepMap CRISPR Gene Dependency 1.0 2.47573 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.5496 GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844243 GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles 1.0 1.1548 hsa-miR-4646-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 abnormal motor capabilities/coordination/movement MPO Gene-Phenotype Associations 1.0 null Ventral tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66019 Primary somatosensory area, lower limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.95183 PMC11574045-44318_2024_257_MOESM4_ESM.xlsx-Sheet1-Dataset_EV2_TEAD4-interacting_proteins_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOLT-16 COSMIC Cell Line Gene Mutation Profiles 1.0 null abnormality of cellular immune system GWASdb SNP-Phenotype Associations 1.0 0.093544 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.14127 MKN1 CCLE Cell Line Gene CNV Profiles -1.0 -1.66939 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962275 non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QXCU-1926-SM-48FE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04498 Nerve Degeneration CTD Gene-Disease Associations 1.0 1.32251 GTEX-U4B1-0326-SM-3DB8K GTEx Tissue Sample Gene Expression Profiles 1.0 0.838867 CTSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33521 T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35502 GTEX-XXEK-0926-SM-4BRWH GTEx Tissue Sample Gene Expression Profiles 1.0 0.888201 TP53 ChEA Transcription Factor Targets 1.0 null Vastus medialis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.114 Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.21215 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SRF_SRF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles 1.0 1.2851 SAP30BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22786 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RFC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19114 GTEX-PW2O-0008-SM-48TEB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Learning Disorders CTD Gene-Disease Associations 1.0 1.8854 PPIL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31737 DA-35-DU85_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.802243 Medial preoptic nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0591 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null GTEX-QMR6-0011-R6A-SM-32PKP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872881 abnormal cardiovascular system physiology MPO Gene-Phenotype Associations 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Familial hypertrophic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.353 Scapuloperoneal myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.143 GTEX-X638-0326-SM-47JY1 GTEx Tissue Sample Gene Expression Profiles 1.0 2.22308 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.74171 periventricular stratum of m2AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31934 dorsal part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.19496 DE-97-IV02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.323194 GTEX-XPT6-0126-SM-4B65S GTEx Tissue Sample Gene Expression Profiles 1.0 1.05605 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP11C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05131 GTEX-T6MN-0126-SM-32PLP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.8913 GTEX-WFG8-0626-SM-3GILJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.895068 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12231 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null snoutepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959223 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29052 PMC9942993-pone.0281645.s002.xlsx-AR-as_adaptive-SYMBOL_AR Rummagene Transcription Factor Associations 2026 1.0 null Obstructive lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.433 PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles 1.0 1.38848 Brain Lower Grade Glioma_LGG_TCGA-TM-A7C4-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null CXCL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86467 protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-X4EP-3226-SM-3P5YR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866884 GTEX-S4P3-0526-SM-4AD58 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44169 TMUB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44211 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null planum temporale, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.828798 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.64441 dentate (lateral) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.865622 Perturb_6607_KO_KEAP1_ERP124775 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.06363 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.839383 GSE164874_5_v_6_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Zinc finger, RING-type, conserved site InterPro Predicted Protein Domain Annotations 1.0 null UBR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32162 cytoskeletal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.275202 PRF1 Pathway Commons Protein-Protein Interactions 1.0 null interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23451 Arsenic CTD Gene-Chemical Interactions 1.0 null NANOG-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE199255,GSE199356_3_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Mesothelioma_MESO_TCGA-SC-A6LN-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.40039 Tibial muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.531 periventricular stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.0261 GTEX-UTHO-0726-SM-3GAEN GTEx Tissue Sample Gene Expression Profiles 1.0 1.17171 GSE114883_1_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.887033 PCYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41208 H3K27me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_DN_AA_DN-AA_DN_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE198254_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Critical illness polyneuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 lateral spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80292 GSE217363_4_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE93309_5_v_3_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Hand1::Tcf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.6207 Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_1_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null ubiquitin-protein transferase activity GO Molecular Function Annotations 2025 1.0 null MAP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70969 ISTMEL1 DepMap CRISPR Gene Dependency 1.0 3.13745 GTEX-PWCY-0726-SM-48TCS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 periventricular stratum of m1AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51293 ZBTB7A ENCODE Transcription Factor Targets 1.0 null Myofibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.411 Parasubthalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43771 DDAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20845 ABC1 CCLE Cell Line Gene CNV Profiles 1.0 1.82993 GSE131377_4_v_2_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054481 IZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04224 HCC1195 CCLE Cell Line Gene CNV Profiles 1.0 1.59064 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FB-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.844384 muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.571219 posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.951048 PMC11611169-pone.0314092.s001.docx-3-PPARG_PPARG Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55C-0326-SM-3GAF1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.854196 HJURP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45453 protein ubiquitination GO Biological Process Annotations 2023 1.0 null Anteromedial visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40511 GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles 1.0 0.927604 GTEX-S4Q7-1526-SM-3K2AG GTEx Tissue Sample Gene Expression Profiles 1.0 1.00294 intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 dorsomedial part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.37567 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-11A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcomere COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.403 GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles 1.0 2.05835 Skeletal muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.824 GSE195786_0_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null COLO-824 COSMIC Cell Line Gene Mutation Profiles 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924297 diagonal part of septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3153 GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles 1.0 1.84896 posteroventral (inferior) parietal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.927367 GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.0897 mantle zone of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01239 striated muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.21891 heart GTEx Tissue Gene Expression Profiles 1.0 1.22775 abnormal cell death MPO Gene-Phenotype Associations 1.0 null HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32511 FLI1-21867929-CD8-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Meiotic prophase fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null Costamere COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.412 FOXG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3229 H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LIM1215 COSMIC Cell Line Gene Mutation Profiles 1.0 null LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.952172 NOL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.9248 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83868 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.831426 medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836262 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE237040_2_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null PK8 DepMap CRISPR Gene Dependency 1.0 3.09868 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE207787_3_v_2_pdha1_human RummaGEO Gene Perturbation Signatures 1.0 null Arm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.349 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AR-35413990-HUMAN-ARPOSCRPROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null MUTZ8 DepMap CRISPR Gene Dependency 1.0 4.29487 Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70559 GSE160077,GSE160084_3_v_0_bin1_mouse RummaGEO Gene Perturbation Signatures -1.0 null OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.880778 parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38418 peduncular part of dorsomedial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1584 sarcomere COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.625206 mortality/aging MPO Gene-Phenotype Associations 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null H3K27me3_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-0326-SM-4GIEE GTEx Tissue Sample Gene Expression Profiles 1.0 0.906578 microtubule binding GO Molecular Function Annotations 2015 1.0 null GTEX-XBED-0526-SM-47JY3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.989029 GSE195559_0_v_9_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.902056 GSE149901_2_v_0_anlotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S4Q7-1126-SM-4AD6R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05747 H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JVM3 DepMap CRISPR Gene Dependency 1.0 2.71976 layer 4 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39336 AC-30-XU83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.929738 thin ventricular wall MPO Gene-Phenotype Associations 1.0 null frontal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33212 NANOG-16153702-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SW 900 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.885391 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.68346 RBBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.089 Perturb_15861_KD_ETS1_SRP270313 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MANBAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18647 PSME4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44241 GTEX-T6MO-1626-SM-32QOM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 regulation of microtubule depolymerization GO Biological Process Annotations 2023 1.0 null HDAC6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null artery disease GWASdb SNP-Disease Associations 1.0 0.138447 G-402 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48763 GTEX-XBEW-1426-SM-4AT4J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 KDM5B ENCODE Transcription Factor Targets 1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of microtubule-based process GO Biological Process Annotations 2015 1.0 null UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16582 PDCD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71534 orbital frontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.947612 REH Achilles Cell Line Gene Essentiality Profiles 1.0 2.26665 RCM1 DepMap CRISPR Gene Dependency 1.0 2.44001 ADAM15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04535 GRINA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87894 GTEX-RUSQ-0926-SM-47JWU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 central part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26964 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.990889 layer 1 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28548 Prostate adenocarcinoma_PRAD_TCGA-G9-7523-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EEF1AKMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07889 FOXF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5623 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles 1.0 1.14088 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SE-0008-SM-33HB1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95 Primary somatosensory area, lower limb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5703 medial mammillary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12499 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SSA3-0326-SM-32QPS GTEx Tissue Sample Gene Expression Profiles 1.0 1.31432 GSE169697,GSE169725_1_v_4_prrx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null transition metal ion binding GO Molecular Function Annotations 2025 1.0 null Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.131 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H8-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organ system cancer GWASdb SNP-Disease Associations 1.0 0.06278 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5DU-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8350019-mmc3.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles 1.0 1.23783 GSE168797_1_v_5_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null ELOVL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91424 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.08061 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.86861 NUGC4 CCLE Cell Line Gene Expression Profiles 1.0 2.65492 ROS50 DepMap CRISPR Gene Dependency 1.0 3.78805 dorsal part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3197 CHD7 ENCODE Transcription Factor Targets 1.0 null Basolateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02429 GK_KO_GDS2610_162_mouse_Brown adipose tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-OHPN-2726-SM-2I5H4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2555 CREBZF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04678 ZBTB7A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCCOHT1 DepMap CRISPR Gene Dependency 1.0 2.33394 microcephaly, seizures, and developmental delay DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.718 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TEAD1 JASPAR Predicted Transcription Factor Targets 1.0 null Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 TE5 CCLE Cell Line Gene Expression Profiles -1.0 -1.55696 GSE203308_15_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null negative regulation of cytoskeleton organization GO Biological Process Annotations 2015 1.0 null PISD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17435 Skin Cutaneous Melanoma_SKCM_TCGA-RP-A694-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NAPRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00634 Primary somatosensory area, unassigned, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28868 Primary somatosensory area, lower limb, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36312 GTEX-NPJ8-0326-SM-2D7VV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Primary somatosensory area, trunk, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21009 Perturb_7807_KD_CSTF2_SRP071700 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.20215 GSE199255,GSE199356_3_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-A46V-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4428 TargetScan Predicted Conserved microRNA Targets 1.0 0.212286 ES4 DepMap CRISPR Gene Dependency 1.0 3.60984 GSE195559_2_v_4_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.85555 H4K20me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dactinomycin_homo sapiens_gpl7172_gse12459 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50716 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.68 Psoas TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.897 EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6127_KO_NEUROD1_SRP170936 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -16.1333 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles 1.0 1.2557 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.22032 Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.519 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior paraventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44482 Pparg::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.6352 TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null superficial stratum of r4BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33178 prostate HPA Tissue Gene Expression Profiles 1.0 0.86305 supragenual nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01864 retroreuniens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68066 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles 1.0 1.21297 NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.64808 dorsolateral isthmic part of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47816 GTEX-U3ZH-1926-SM-4DXTR GTEx Tissue Sample Gene Expression Profiles 1.0 2.74545 KMS34 DepMap CRISPR Gene Dependency 1.0 2.92368 GTEX-X4EP-0326-SM-3P5Z6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.855244 FOXK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7216 PMC9942993-pone.0281645.s002.xlsx-AR-as_adaptive-ENSEMBL_AR Rummagene Transcription Factor Associations 2026 1.0 null hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.975499 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07741 NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04055 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.849268 GSE149010_0_v_6_dars2_mouse RummaGEO Gene Perturbation Signatures -1.0 null IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.925149 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TTLL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16937 GSE152937_12_v_7_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH211 CCLE Cell Line Gene Expression Profiles 1.0 1.37276 GTEX-T5JC-0008-SM-4DM6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-TML8-1826-SM-32QOR GTEx Tissue Sample Gene Expression Profiles 1.0 1.73628 ARHGDIG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40983 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.45389 Cylindrical spirals myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.56 NH12 DepMap CRISPR Gene Dependency 1.0 4.18184 GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.958845 Perturb_2604_OE_SEPTIN9_SRP159553 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.5511 Cardiac myofibril COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.311 Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26068 MAPRE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09452 GRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38484 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A3U8-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r4 part of medial paralemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37119 DHRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39062 GTEX-TSE9-1226-SM-4DXTM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15993 subethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04018 Primary cerebellar degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.231 CCDC43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08308 GSE63048_11_v_6_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.942197 all GWASdb SNP-Phenotype Associations 1.0 0.037835 NCIH2452 DepMap CRISPR Gene Dependency 1.0 3.10927 GSE186440,GSE186443_2_v_5_daxx_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH1836 DepMap CRISPR Gene Dependency 1.0 3.26624 Cytosolic creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.776 CoPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47816 lung disease GWASdb SNP-Disease Associations 1.0 0.20671 dh82 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.638 DU4475 CCLE Cell Line Gene Expression Profiles 1.0 2.05627 GTEX-XQ8I-0226-SM-4BOPM GTEx Tissue Sample Gene Expression Profiles 1.0 0.846848 MTMR11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54866 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51876 Internal female genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Primary somatosensory area, barrel field, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96259 KCIMOH1 CCLE Cell Line Gene Expression Profiles -1.0 -1.58625 STRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66447 superior periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3152 inferior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15088 GTEX-X5EB-1926-SM-4E3IW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86785 biological regulation GO Biological Process Annotations 2015 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC8635809-Table_2.xls-LPS-downregulated-Unnamed_4_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.15995 Slow twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.414 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.4764 CETN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00945 Retrosplenial area, lateral agranular part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21786 HSPA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32775 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5178-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.927676 TRIM55 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiovascular system phenotype MPO Gene-Phenotype Associations 1.0 null azithromycin_pseudomonas aeruginosa_gpl84_gse12738 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null dilated cardiomyopathy MPO Gene-Phenotype Associations 1.0 null SIRT6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLB985 Achilles Cell Line Gene Essentiality Profiles 1.0 1.74141 GTEX-X261-0011-R7A-SM-4E3JJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-OHPL-2426-SM-48TDN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06345 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ANKRD35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48034 L1236 CCLE Cell Line Gene CNV Profiles 1.0 1.99315 GTEX-QVUS-0008-SM-447AY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 bladder GTEx Tissue Gene Expression Profiles -1.0 -0.839981 GE-53-SM76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.782113 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.7838 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.342 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles 1.0 1.2758 GSE48812_9_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null multicellular organismal process GO Biological Process Annotations 2015 1.0 null IGROV-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.4441 finger TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.405935 GSE140200_1_v_0_trim59_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE252857_2_v_3_prednisone_mouse RummaGEO Drug Perturbation Signatures -1.0 null YD15 DepMap CRISPR Gene Dependency 1.0 3.17213 GTEX-XUZC-0008-SM-4BOQG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125014_1_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null SNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00393 Kidney Neoplasms CTD Gene-Disease Associations 1.0 1.01212 SNUC4 DepMap CRISPR Gene Dependency 1.0 2.81202 GTEX-V955-0726-SM-3GAFG GTEx Tissue Sample Gene Expression Profiles 1.0 0.868226 GTEX-QDVN-0008-SM-48U2D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null vascular bundle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.129009 macromolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null negative regulation of microtubule polymerization or depolymerization GO Biological Process Annotations 2023 1.0 null amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21707 GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles 1.0 0.966176 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles 1.0 1.55262 GSE182180_1_v_2_secretin_human RummaGEO Drug Perturbation Signatures -1.0 null basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.960687 AB-18-YN11_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.422582 RORC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0319 GSE129241_4_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Fetal Death CTD Gene-Disease Associations 1.0 1.4966 GTEX-X8HC-1526-SM-46MWD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 SARNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52877 Genetic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.638 rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.909912 X-linked monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.286 orbital frontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.945103 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles 1.0 1.51807 X-linked recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.359 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35361 GTEX-P4PP-0008-SM-48TDV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GTEX-NL3H-0011-R5a-SM-2I3GB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 201T COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE228181_0_v_5_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null hematopoietic system disease GWASdb SNP-Disease Associations 1.0 0.098779 GTEX-TML8-1526-SM-4DXUX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 GSE43041,GSE43044_0_v_1_ldb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE210682_2_v_3_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null negative regulation of cellular process GO Biological Process Annotations 2015 1.0 null heart_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.16222 Hyaline body myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.522 shell of P-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18344 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.40147 Perturb_15828_OE_Nrf2_SRP291726 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.53318 Adenoma, Liver Cell CTD Gene-Disease Associations 1.0 1.12219 dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01623 Perturb_15237_KD_TINCR_SRP082178 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PSMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70029 Proteasome core complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.807 GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles 1.0 1.74818 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5191-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03805 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GT-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sox6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.4378 Lung adenocarcinoma_LUAD_TCGA-78-8660-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5807 GSE211262,GSE211263_3_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null OCILY10 CCLE Cell Line Gene Expression Profiles 1.0 1.57388 CLK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98641 JARID1B-DAIN-22020125-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SW1116 DepMap CRISPR Gene Dependency 1.0 2.1733 GTEX-XQ3S-0626-SM-4BOOB GTEx Tissue Sample Gene Expression Profiles 1.0 0.966103 GNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30504 NCIH322 CCLE Cell Line Gene CNV Profiles 1.0 1.95922 hsa-miR-4520b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.14383 EMC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17539 GSE239436,GSE239441_0_v_1_keap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE217541,GSE217543_0_v_1_tet1_human RummaGEO Gene Perturbation Signatures -1.0 null NCIH2052 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.40672 heart_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.12741 striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26265 TEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30834 A2780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48463 GTEX-RWS6-0326-SM-2XCAP GTEx Tissue Sample Gene Expression Profiles 1.0 0.86393 PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF Rummagene Transcription Factor Associations 2026 1.0 null SEKI DepMap CRISPR Gene Dependency 1.0 4.75867 TGFBI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34054 dilated heart MPO Gene-Phenotype Associations 1.0 null GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles 1.0 1.37888 BCL3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null external cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28868 layer 4 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04018 PCBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76537 Non-Small Cell Lung Carcinoma DisGeNET Gene-Disease Associations 1.0 null Myotonic dystrophy type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.011 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-RM2N-1126-SM-48FCY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 JB-14-ZM03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.520848 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.186 GTEX-SUCS-0726-SM-4DM7J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29111 Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.8336 contractile fiber part GO Cellular Component Annotations 2015 1.0 null microtubule cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.512047 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Katanin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.866 G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03673 GSE146074_1_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null icSARS CoV_12Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.44247 MYF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7905 NOMO1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.94795 ott1_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -1.14287 M059J Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.902913 AE-13-CX28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.449717 MKNK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0734 H3K9me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null abnormal cardiac muscle contractility MPO Gene-Phenotype Associations 1.0 null microtubule cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.682 GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.973637 RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRDX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05307 GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles 1.0 1.3536 GSE157383_6_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null postcentral gyrus, left, bank of the central sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.834884 plumule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067429 oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.6135 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE128333_3_v_5_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null PPARD_KO_GDS4320_619_mouse_Pancreas GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null basolateral amygdaloid nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11418 H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null EN COSMIC Cell Line Gene Mutation Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-CL-5917-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4773428-ncomms10751-s5.xlsx-S_Table_4-Supplementary_Data_4_RUNX1_responsive_genes_in_the_presence_and_absence_of_estradiol_E2_in_MCF7_cells_FC_1_5_p_0_05_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null abnormal myocardium layer morphology MPO Gene-Phenotype Associations 1.0 null striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06831 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1692 Acute Myeloid Leukemia_LAML_TCGA-AB-2950-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RWSA-0626-SM-2XCBD GTEx Tissue Sample Gene Expression Profiles 1.0 0.85689 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.900919 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36945 GTEX-QDVJ-1926-SM-2S1PJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.90103 GSE201309_4_v_3_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35002 CEBPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2383 AKT1_knockout_212_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.43619 GSE120413,GSE120447_4_v_2_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null