association	dataset	threshold value	standardized value
GSE111247_11_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51316
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.603451
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319371
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27719
CAL120	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95437
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9272
GSE238018_3_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.60085
Treprostinil	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GSE173810_4_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174586_0_v_1_slc4a11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
19043454-TableS2	GeneSigDB Published Gene Signatures	1.0	null
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7335
SNU899	CCLE Cell Line Gene CNV Profiles	-1.0	-2.45206
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929798
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Spautin-1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.58
Inflammation	CTD Gene-Disease Associations	1.0	1.04352
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE140997_4_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_3_AP1_Up_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Thymidine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Butyrophylin-like	InterPro Predicted Protein Domain Annotations	1.0	null
LRRC57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50781
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25022
BB-11-JI42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.566571
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162104
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCHEMBL5061501	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115591
parasubicular cortex (parasubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.30413
GSE154246_2_v_0_haspin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
olfactory tubercle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5571
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.69989
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6012
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8894
A549_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151942
NCI-H510A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
orbital frontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.88075
BL4711 (PDCD4)	NURSA Protein Complexes	1.0	null
AU565	DepMap CRISPR Gene Dependency	1.0	4.83121
CHSA0108	COSMIC Cell Line Gene Mutation Profiles	1.0	null
response to lipid	GO Biological Process Annotations 2015	1.0	null
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.61
HCC1599	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
PEX11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57445
A549_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179499
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_2087_KO_APTX_SRP174572	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_4861_KD_SON_ERP003259	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.12024
A549_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131162
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BE-17-CS60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241758
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
JD-62-TK68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378033
A549_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236737
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00504
protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.38289
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RV16_0Hour-B2B_None_GSE28904	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.08577
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52982
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.86152
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218547
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
Perturb_5172_KO|KD_Sirt1|Otx2_SRP075247	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855271
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0174
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832735
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5294
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIKFYVE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18713
Perturb_13224_KO_Stat3_SRP213608	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77765
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33935
Lung squamous cell carcinoma_LUSC_TCGA-98-8020-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.945376
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4773428-ncomms10751-s5.xlsx-S_Table_4-Supplementary_Data_4_RUNX1_responsive_genes_in_the_presence_and_absence_of_estradiol_E2_in_MCF7_cells_FC_1_5_p_0_05_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Smoking	DisGeNET Gene-Phenotype Associations	1.0	null
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JV-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.969
Perturb_12288_KO_USP18_SRP303136	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.672
Perturb_17665_OE_RAB44_SRP305964	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29182
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE206779_4_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE179002_4_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31076
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85423
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13892
Rectum adenocarcinoma_READ_TCGA-F5-6811-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1516
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.78352
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16154
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	2.03585
VTI1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20452
MAFK	ENCODE Transcription Factor Targets	1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23664
SUMO2	Hub Proteins Protein-Protein Interactions	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.692207
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4891
496100363_TCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44955
PMC9580020-tx2c00131_si_003.xlsx-Fig_5A_data-HSF1_KOVAC_same_dataset_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
SK-LU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.884628
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0028
Hepa-RG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.766
MM383	DepMap CRISPR Gene Dependency	1.0	11.9163
HPAFII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5514
Brain Lower Grade Glioma_LGG_TCGA-S9-A89Z-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4044
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YV-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406023
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Hypopharyngeal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.972
GSE176008_8_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013526
METTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96023
ZNF513	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42992
PGS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14661
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.877936
Lung adenocarcinoma_LUAD_TCGA-05-4434-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CNOT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25576
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2873957-pone.0010709.s003.xls-OCT4-only_OCT4_motif_present_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE127790_5_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7067
PMC10760404-NIHMS1688779-supplement-Supplementary_Table_S6.xlsx-EMP_CREB_Targets-symbol_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159786
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33935
GYPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09486
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
biological_process	GO Biological Process Annotations 2015	1.0	null
NCI-H520	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299895
TE8	CCLE Cell Line Gene Expression Profiles	1.0	1.36921
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BJAB cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.176
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250133
A549_BMS-911543_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015104
body of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.6501
Breast Cancer_Mammary Gland Tissue_GSE3744	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.23777
reticular nucleus of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.98608
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7283
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
TE-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.585409
S0-EE-XKW4_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237556
RB1_KD_GSE50532_624_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
KP-N-RT-BM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06851
Perturb_17217_KD_NANOG_ERP128142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
OTX2_01_268	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.78039
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.468637
RNF121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84275
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46454
gm02185	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.864
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
COLO829	CCLE Cell Line Gene Expression Profiles	1.0	3.40828
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52005
Perturb_14362_KD_SORBS2_SRP112756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.30276
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
SREK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74036
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
RMGI	CCLE Cell Line Gene CNV Profiles	1.0	1.44936
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HEC1B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86461
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.74752
SB 334867	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.977927
BE-42-IC00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298929
POU6F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8336
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6334
PAP-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79257
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04002
A549_Hesperadin_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221032
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
DANG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45811
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.12414
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32534
BRCA1	JASPAR Predicted Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826319
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220154
BL567 ()	NURSA Protein Complexes	1.0	null
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60535
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-0.884628
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019557
SMARCA4	ChEA Transcription Factor Targets	1.0	null
H3K36me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A3OT-06A-23R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18692
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
B30.2/SPRY domain	InterPro Predicted Protein Domain Annotations	1.0	null
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.3853
Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MIR221_KD_GDS4054_455_human_MCF7 breast cancer cells (fulvestrant-resistant)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A40E-01A-12R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40725
Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComUP-List-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.830626
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447438
WDR45B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55489
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23642
CEBPB	ENCODE Transcription Factor Targets	1.0	null
TAL1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27349
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.833117
GSE186647,GSE217288_2_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
NUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13113
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.489636
HK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15768
LNZTA3WT4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46D-01A-21R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKG-IIIA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NB17	DepMap CRISPR Gene Dependency	1.0	17.7137
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ligase activity	GO Molecular Function Annotations 2015	1.0	null
A549_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.041943
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_11878_OE_miR30a5p_SRP238971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Supplementary_Table_2C_Contrast_ATF4-def_DMSO_8h_vs_HCT116_DMSO_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE138818_2_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6012_KD_ERH_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2131
NCIH2081	CCLE Cell Line Gene Expression Profiles	-1.0	-2.57565
DA-40-HO94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.426249
Perturb_16001_KO_TP53_SRP261893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CDK19_knockdown_162_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.50315
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03758
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Fluorouracil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185952
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MRS 2578	DeepCoverMOA Drug Mechanisms of Action	1.0	0.65
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.964
PMC9580020-tx2c00131_si_004.xlsx-Fig_5B_data-TABLE_S3_CORE_GENE_TARGETS_HSF1_KOVACS_ET_AL_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
ZDHHC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02413
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27585
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9527
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393479
MAN2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27736
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.472
HER2_OE_GDS4763_331_human_MCF10A - immortalized breast epithelial cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
A549_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169803
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98146
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3803
Prostate adenocarcinoma_PRAD_TCGA-EJ-7788-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bewo	HPA Cell Line Gene Expression Profiles	1.0	1.00846
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.75504
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.49409
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15991
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.145
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481616
MDAMB361	DepMap CRISPR Gene Dependency	1.0	2.67797
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF684	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19199
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3A-Down_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12086
SOX2_Deficiency_GDS4853_321_human_AZ-521 gastric cancer (GC) cell line - 18 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2935-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27291
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE156907,GSE160237_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
mRNA_SALL4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2023	1.0	null
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12949
KARPAS-422	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.968495
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05431
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87255
Lung adenocarcinoma_LUAD_TCGA-53-7624-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261715
Facioscapulohumeral muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.346
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4955
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2597
A549_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.034382
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.855823
RBM23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01639
testis	HPA Tissue Protein Expression Profiles	1.0	0.822322
HCC1599	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.61078
Perturb_6869_OE_STBD1_SRP316253	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.84485
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU1076	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95062
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9795
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162068
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Eye-radial glial cell	Tabula Sapiens Gene-Cell Associations	1.0	1.32036
Perturb_1355_KO_circSCL38A1_SRP342299	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.0399
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4419
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7603494-41467_2020_19353_MOESM6_ESM.xlsx-Ch_TCF3_up_and_binding_Overlapp-Unnamed_1_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.41342
GSE205291,GSE205292_1_v_3_drd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.864307
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.355525
FA-47-IB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406853
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.875495
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr4_188106273_G_T_b38	GTEx eQTL 2025	1.0	4.74666
OCILY3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74595
CASTOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15328
EE-01-FB85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204085
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.88672
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Timapiprant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855271
esophagus	HPA Tissue Protein Expression Profiles	1.0	1.28886
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE98755,GSE98756_1_v_0_fbxl19_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10929187-ijbsv20p1547s4.xlsx-JQ1-dep_ATF4-XBP1signature-ABCC9_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
SUM229PE	DepMap CRISPR Gene Dependency	1.0	2.44407
spleen	GTEx Tissue Gene Expression Profiles	-1.0	-1.28554
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-Upstream_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12003
TOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24336
MYC	ENCODE Transcription Factor Targets	1.0	null
Labyrinthine zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.86
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_01_113	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60237
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A-CA-04-2009(H1N1)_24Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.37252
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32534
ZMIZ1_02_181	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.22239
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6061
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266534
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GR-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213905
GSE167474_2_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.84063
CLDN1_OE_GDS3510_393_human_CL1-5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
LMSU	CCLE Cell Line Gene Expression Profiles	1.0	1.50871
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4415-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.12679
ESRRA_01_280	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.96954
CHK1_KD_GSE54267_672_human_U2OS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26923
NCIH1355	CCLE Cell Line Gene CNV Profiles	1.0	1.52645
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29719
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7399
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
protein ubiquitination	GO Biological Process Annotations 2023	1.0	null
B-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.694966
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
OA-54-FL10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.76169
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.22758
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
TE14	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13967
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05653
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29182
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.61209
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.37535
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01678
KIF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29904
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6334
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE86813,GSE86814_0_v_1_atf7ip_human	RummaGEO Gene Perturbation Signatures	1.0	null
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377081
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	1.0	null
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Perturb_6578_KO_Zeb2_SRP066910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
superior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.947031
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A913-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31609
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134483
LB-65-SM65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349925
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.850355
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
stratum oriens of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.063
SPRY-associated	InterPro Predicted Protein Domain Annotations	1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11293
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.753
Perturb_417_OE_PINK1_SRP327521	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.31751
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11992
SNUC5	CCLE Cell Line Gene Expression Profiles	1.0	1.53456
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.4022
A549_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171752
GSE64642_0_v_1_sirt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAFK_02_183	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60768
Lung squamous cell carcinoma_LUSC_TCGA-21-1079-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152613
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6420765-12864_2019_5550_MOESM5_ESM.xlsx-D9_vs_D15-Unnamed_5_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
BEN	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5498
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6112
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19797
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8S1-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6307_KD_NR2F1AS1_SRP335917	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.58695
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.829234
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-11-RK51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316487
Lung adenocarcinoma_LUAD_TCGA-50-5072-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7273
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_state_markers-AP1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_11_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3659
CUX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9005
ubiquitin protein ligase activity	GO Molecular Function Annotations 2023	1.0	null
GSE248874_1_v_0_pcdh9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Testicular cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
A549_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120208
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.67068
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5697
Ft	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.979
H3K36me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YE-80-LN04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.62819
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4A-Down_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9783_KD_Tcf7l1_SRP321923	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.45109
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169961
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36719
A549_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117414
Perturb_2841_OE_MUSK_SRP357777	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.3045
A549_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0350198
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC4407272-elife06857s002.xlsx-501M_BRG1-MITF_ComUP-List-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rectum	HPA Tissue Protein Expression Profiles	1.0	1.28886
AMO1	DepMap CRISPR Gene Dependency	1.0	3.56309
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A43B-01A-81R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.555339
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.945725
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.711
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164494_1_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.473
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4103
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6606_KD_CMTM6_ERP123354	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DF-75-OU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386586
BCPAP	CCLE Cell Line Gene Expression Profiles	1.0	1.84385
GSE172019_2_v_8_rnf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SA-53-XG95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369328
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.054386
HLF	CCLE Cell Line Gene CNV Profiles	1.0	1.69314
HCC1359	CCLE Cell Line Gene Expression Profiles	1.0	1.42
A549_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117551
SW403	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7454
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
dorsolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0237
SCC9	CCLE Cell Line Gene Expression Profiles	1.0	1.53213
SNU182	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51985
A549_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142341
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0481
Perturb_13797_KO_Phc1_SRP096055	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
anterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.965383
HCC1187	DepMap CRISPR Gene Dependency	1.0	7.4476
BC-75-FA82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.523897
MOLP2	CCLE Cell Line Gene CNV Profiles	1.0	2.11375
hsa-miR-515-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.57569
PLCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01176
CAL78	CCLE Cell Line Gene CNV Profiles	1.0	2.70947
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.98235
A204	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HADHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17575
TC-95-IR96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280805
BT-474	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Alectinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.57
A549_Danusertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153312
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51652
NCI-N87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PTEN_KD_GDS2958_100_human_HCC827 - NON-SMALL CELL LUNG carcinoma cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
parkinson's disease	GWASdb SNP-Disease Associations	1.0	0.751885
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Sarcoma_SARC_TCGA-DX-AB2Z-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.764
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.644368
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
OCI-LY-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985474
TET2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14793
IWR-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5232
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179002_3_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10619
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLDN1_OE_GDS3510_31_human_CL1-5 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Gene_name_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
FREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06921
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.6835
membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10501
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.81245
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.50045
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23728
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-SOX2-Unnamed_2_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Cetrorelix	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-0.884628
A549_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028974
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7897-01A-21R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.57879
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Conceptus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.805
A549_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168353
SD-208	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.57
AQP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51427
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58051
H3K9me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-Symbol_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.61
NH6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48434
caudal putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40778
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TH-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VU 0364439	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.55
Rectum adenocarcinoma_READ_TCGA-AF-6672-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLEKHH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95311
CUX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3651
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206516,GSE206518_2_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3262
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343833
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.28886
Prostate adenocarcinoma_PRAD_TCGA-G9-6365-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100337_HIP_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00803
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8563-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5102
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6281
A549_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151264
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Mesothelioma_MESO_TCGA-MQ-A6BN-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK5RAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3146
TMEM37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34728
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YBX1_01_257	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.57757
BB-42-FF52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234276
RARRES1_KD_GDS4818_314_human_SUM149	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228106_0_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IA-76-ZU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.513625
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9051_KD_CACTIN_SRP075920	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE168797_1_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of macromolecule metabolic process	GO Biological Process Annotations 2023	1.0	null
PGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54374
Brain Lower Grade Glioma_LGG_TCGA-P5-A730-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168797_1_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17446
CHD1	ENCODE Transcription Factor Targets	1.0	null
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197923
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142637
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.7887
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.74349
HUO9	DepMap CRISPR Gene Dependency	1.0	2.19887
A549_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197856
PARP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57955
A427	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.987671
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_383_KD_NFE2L2_SRP158498	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.6714
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0461
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7256
WDR12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2323
Perturb_5287_KO_Setdb1_SRP226379	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.94999
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7181
GSE150072,GSE169209_4_v_10_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39356
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136329
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03735
BB-84-DG64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216078
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
S0-EE-YEKU_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232684
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DG-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12915
COLO824	DepMap CRISPR Gene Dependency	1.0	7.49191
MERO83	DepMap CRISPR Gene Dependency	1.0	3.18424
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X3-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08685
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
ZNF827	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0406
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60828
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18627
ANKRD13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06654
JEG-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.359789
Doramapimod	DeepCoverMOA Drug Mechanisms of Action	1.0	0.58
GSE173201_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TUBB4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04368
Prostate adenocarcinoma_PRAD_TCGA-VN-A88I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHU-011	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.61078
Prostate adenocarcinoma_PRAD_TCGA-EJ-5522-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.36824
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4966_KO_Setdb1_SRP226379	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906435
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32353
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHK1_KD_GSE54267_671_human_U2OS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_434_KD_U2AF1_SRP055860	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.68591
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127328
Rectum adenocarcinoma_READ_TCGA-CI-6622-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RB1_KD_GSE50532_660_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_12184_KD_LATS1/LATS2_SRP065500	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.59351
GSE242290_1_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
JD-87-KA71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323048
OACP4C	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.61078
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	-1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42704
SLC17A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3211
A549_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013468
AQR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67233
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252289
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.6303
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PCNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24071
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Glycogen storage disease IXa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1383
YD15	CCLE Cell Line Gene Expression Profiles	1.0	1.96329
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.703903
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8061-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEIS1-26253404-OPTIC-CUPS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
SMAD1-26771354-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
SLIK (SAGA-like) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.029
NCI-H1838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.872855
ARPC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64273
TCF3_01_116	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.32805
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549	CCLE Cell Line Gene Expression Profiles	1.0	1.58574
FYCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52717
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221106
Methylosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.265
mRNA_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10913
Perturb_14604_KD_SIRT1_SRP312694	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE113817_2_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE222758_0_v_2_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04883
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8017
TD-48-XJ84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283692
GSE238018_1_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158182_3_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06756
mRNA_POU5F1_20526341	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8624
GON4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42579
Lung squamous cell carcinoma_LUSC_TCGA-77-8130-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155805
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
DHRS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57083
SN12C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KLE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IRX1_01_227	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.67306
Perturb_15479_KD_ECI2_SRP066238	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.71792
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.341
A549_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123385
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.1287
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86187
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.949588
response to stimulus	GO Biological Process Annotations 2015	1.0	null
FF-96-HL81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26259
JA-85-SW39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3888
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5ST-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7014-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144919,GSE145177_1_v_0_dazl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_POU5F1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO849	CCLE Cell Line Gene Expression Profiles	1.0	2.40871
H3K79me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0203
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
Polycystic ovary syndrome	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
639-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63646
lateral parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.998753
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.096
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-AA_UP_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8242083-41467_2021_24064_MOESM4_ESM.txt--HSF1_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF665	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23255
Paricalcitol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
CF-24-KQ98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276866
HCC1428	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65521
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350767
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.6194
cSARS Bat SRBD_54Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.22679
FB-95-JD99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263268
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4013
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-A_FUS-DDIT3_vs_both_controls-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4BB-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178837
SPRY domain	InterPro Predicted Protein Domain Annotations	1.0	null
CAL12T	CCLE Cell Line Gene Expression Profiles	1.0	2.25236
layer I of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02792
stratum oriens of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.858261
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
PB-63-WH18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236797
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9336
NFE2L2_02_174	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.47805
RES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.135
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7645-01A-22R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Concanavalin A-like lectin/glucanase domain	InterPro Predicted Protein Domain Annotations	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.25371
ROS50	DepMap CRISPR Gene Dependency	1.0	2.83365
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ENO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25602
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42553
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-0.884628
SCC-25 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37474
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
NCI-H23 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.625
TCF4	ChEA Transcription Factor Targets	1.0	null
Levosimendan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
DCTN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02396
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
response to chemical	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A7C4-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.987671
Seratrodast	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
GSE85995_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320282
LU99	CCLE Cell Line Gene Expression Profiles	1.0	2.13792
YD8	CCLE Cell Line Gene Expression Profiles	1.0	1.59431
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5377
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE179002_0_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.3704
primary auditory cortex (core)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52564
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	74.0497
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10153265-media-3.xlsx-BENPORATH_NANOG_TARGETS_v2023_1-STANDARD_NAME_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.311
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.4868
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326789
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8157
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876573
PEER	CCLE Cell Line Gene CNV Profiles	1.0	1.57966
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Ensemble_gene_ID_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
PNMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69298
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.581405
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05279
Trophoblast stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.049
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840768
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11838
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-29-ZM45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.605247
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.507
mRNA_OTX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
layer II of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06609
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65876
PF-84-RH50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275633
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
LAMA-84	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FC-22-VC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.465813
PMC11982601-IMM-175-84-s005.xlsx-Fig5D_LPS-Innate_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.984892
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GA-04-JM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.440666
QA-14-AU91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.515135
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-3792-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147943_4_v_6_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
icSARS CoV_36Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.57704
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.99001
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cornified envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.736
Sarcoma_SARC_TCGA-IE-A6BZ-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11893
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Down_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0701
A549_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143431
KIAA0753	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8551
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A8AZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferior rostral gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.937956
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_state_immune_markers-AP1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE216043_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A8NY-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTEN_01_302	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.66998
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135842_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRDM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03683
Ingenol-3-angelate	DeepCoverMOA Drug Mechanisms of Action	1.0	0.63
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.394505
MHHCALL3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.3657
Perturb_9071_KD_HIF2A_SRP141017	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.62796
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372963
SKNAS	CCLE Cell Line Gene CNV Profiles	1.0	1.63152
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-NR2F1_Ind_UP_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
CYP26A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20975
H3K36me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2_Deficiency_GDS4853_322_human_AZ-521 gastric cancer (GC) cell line - 24 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
A549_AT9283_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119677
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06535
Perturb_18499_KO_TWIST1_SRP121466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26435
Amniocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
FARAGE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOSL1_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
LD-39-FL02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.493402
NCI-H1734	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120493
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
FaDu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.974
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9146
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.833
SW-1417 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
Rectum adenocarcinoma_READ_TCGA-DC-6682-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.847
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828006
Prostate adenocarcinoma_PRAD_TCGA-KK-A6DY-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_451_KD_EMS_SRP171802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
HCC366	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40094
SNU840	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6257
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3977
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.151
H3K36me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.09555
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.12025
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67165
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Perturb_405_OE_GFI1_SRP302855	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
adrenal gland	GTEx Tissue Gene Expression Profiles	1.0	1.20353
AC-97-KP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.405156
A549_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119203
EGR1	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4629-01A-02R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OLIG2	ChEA Transcription Factor Targets	1.0	null
RB1_KD_GSE50532_654_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BD-81-LB65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.390874
icSARS CoV_72Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.59472
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.2405
TE-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
response to oxygen-containing compound	GO Biological Process Annotations 2015	1.0	null
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE112760,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.849
ACAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10627
DG-75 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.178
ALL-PO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RB-34-TO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.677868
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161092
EOL1	CCLE Cell Line Gene CNV Profiles	1.0	1.36149
H3K36me3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-75-LR63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242651
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.85927
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
putamen, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.52779
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31693
A549_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013972
NDUFA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23663
H3K36me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHP126	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88162
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00731
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.028643
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112761,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.352
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.83052
NCIH1339	CCLE Cell Line Gene Expression Profiles	1.0	1.44815
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67F-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Smoking Behaviors	DisGeNET Gene-Phenotype Associations	1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.646498
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
a24	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.585
496100375_FWM_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.55364
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_18_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_6849_KO_PRE2_SRP273076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.98552
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.562911
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.108
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11618
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18988
GSE245407,GSE245412_0_v_1_smurf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
786O	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71487
JVM-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19964
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
PL4	DepMap CRISPR Gene Dependency	1.0	3.0218
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15566
SCC25	CCLE Cell Line Gene CNV Profiles	-1.0	-2.26239
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSC3	CCLE Cell Line Gene Expression Profiles	1.0	1.6407
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSNK2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0547
A549_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159576
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ED-02-CL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265234
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3401
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.864658
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.57879
GSE148262,GSE150691_1_v_0_hdlbp_human	RummaGEO Gene Perturbation Signatures	1.0	null
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26427
Perturb_17223_KD_NANOG_ERP128142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.85927
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316478
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21061
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.394849
BeWo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7869_KD_NEK2_SRP256251	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.4109
ZFHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54082
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AP5M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58914
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1039
ID-69-QF93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267023
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840768
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1526
GSE125219,GSE125221_5_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
ACTR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78363
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457357
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
ubiquitin protein ligase activity	GO Molecular Function Annotations 2025	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9630632-Table1.XLSX-diff_exp_genes-Group_1_vs_2_AND_Group_2_vs_3_NOT_Group_1_vs_3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SPART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17625
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CADO-ES1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
INSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19883
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.290859
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7304
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF708	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1676
Her2_OE_GSE43730_683_human_MCF10A cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GEO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE210093_3_v_2_taf15_human	RummaGEO Gene Perturbation Signatures	1.0	null
CJM	CCLE Cell Line Gene Expression Profiles	1.0	1.71331
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TOMM40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15919
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252297
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.882504
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160273
GSE173169,GSE173170_0_v_1_epc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144115_4_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HGC-27	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU738	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80679
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.945496
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H0-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8443
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMAD3-22036565-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EMC-BAC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KDELR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61001
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45T-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LCLC97TM1	CCLE Cell Line Gene CNV Profiles	1.0	1.38417
plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1683
Perturb_9782_KD_Esrrb_SRP321923	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.86944
T3M4	DepMap CRISPR Gene Dependency	1.0	4.02433
PMC9314667-Table_1.xlsx-Regulons-FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TD-17-NF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.470011
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36187
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06918
Radicicol	DeepCoverMOA Drug Mechanisms of Action	1.0	1.06
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58212
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26725
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11324510-41587_2023_1949_MOESM3_ESM.xlsx-Supplementary_Table6-Supplementary_Table_6_TP53_pathway_genes_list_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184133,GSE184137_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pamidronic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
PNPLA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43724
nasopharynx	HPA Tissue Protein Expression Profiles	-1.0	-0.884628
PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
HSD11B1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15646
SP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21597
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266953
Perturb_5236_KO_Abhd11_SRP237744	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.67951
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.863582
A549_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177786
B-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.921
Parkin_OE_GDS4476_55_human_U87MG	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
fusiform gyrus, left, bank of cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.896378
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A1HS-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.5423
A549_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273375
MRPL39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68995
Brain Lower Grade Glioma_LGG_TCGA-P5-A72W-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
Actin wave	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.73
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57106
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE211262,GSE211263_0_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8935
A549_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023436
FASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36061
MTHFS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15163
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282381
Perturb_8658_KO_TP53_SRP251281	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
NCIH2141	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55367
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
planum polare, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02026
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12884
SQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.45662
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65488
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9236
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43234
Mitotic fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
TP53_01_37	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.51863
105KC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.83448
A549_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153559
GINS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1111
TA-19-YA45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205694
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130081,GSE130082_0_v_10_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196523
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27697
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_4573_KO_Pwwp2a/Pwwp2b_SRP255880	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.36943
RPL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04591
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39137
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260675
HCC70	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52055
RPMI-8866	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2110	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE145915_0_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
KASUMI1	DepMap CRISPR Gene Dependency	1.0	2.7675
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875947
Perturb_6300_KD_CGA_SRP355115	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39527
abnormality of central motor function	GWASdb SNP-Phenotype Associations	1.0	0.650754
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4787
Brain Lower Grade Glioma_LGG_TCGA-DB-A75L-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20768
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.59239
A549_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187783
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-11A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6513
TMEM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84624
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8438
Perturb_13892_KD_BRCA1_SRP135799	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.53234
NCI-H358	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6347712-pnas.1812449116.sd06.xlsx-iPSC_IRF7_48h_rest_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.85927
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100460_TCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09996
ZNF667	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01716
Prostate adenocarcinoma_PRAD_TCGA-EJ-5526-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
170MGBA	DepMap CRISPR Gene Dependency	1.0	2.21982
MFE296	DepMap CRISPR Gene Dependency	1.0	3.66289
Perturb_12374_KO_USP18_SRP303136	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.561722
ACCMESO1	CCLE Cell Line Gene Expression Profiles	1.0	1.80551
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
A549_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129868
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
HLC1	CCLE Cell Line Gene Expression Profiles	1.0	1.94756
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263153
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6975
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.60914
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7565
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09364
Lung squamous cell carcinoma_LUSC_TCGA-56-8201-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7918644-LSA-2020-00974_TableS2.xlsx-5_SAd2_BD_D-GATA3_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04164
PMC9314667-Table_1.xlsx-Regulons-ATF5_ATF5	Rummagene Transcription Factor Associations 2026	1.0	null
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888899
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RT-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7793
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	1.0	null
NUGC3	CCLE Cell Line Gene Expression Profiles	1.0	1.75417
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.884628
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09233
ERA-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE238018_3_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRKCI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58553
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-04-AN21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.483854
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.92365
IRF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1213
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Rucaparib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8727
Endocrine system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
H3K9me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KMH2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36735
Mel-18_KD_GDS2724_103_human_DAOY medulloblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
UCHL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91827
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.57879
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_3664_KD_RBM27_SRP243927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.273
SU8686	CCLE Cell Line Gene CNV Profiles	1.0	1.43661
PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KNS42	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6625
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BORA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02076
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12643271-pone.0336502.s009.xlsx-S2_Table-S2_Table_AXL_and_MITF_signature_genes_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SNU182	CCLE Cell Line Gene Expression Profiles	-1.0	-2.6846
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JO-01B-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42E-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6677_KD_ROBO3_ERP130576	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.874314
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19964
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7LX-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1507
Perturb_17220_KD_NANOG_ERP128142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7434
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27477
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9568
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	1.0	null
synucleinopathy	GWASdb SNP-Disease Associations	1.0	0.751885
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19964
Sarcoma_SARC_TCGA-DX-A6YV-01A-12R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BCP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.375
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.89241
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66199
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.951201
127399	DepMap CRISPR Gene Dependency	1.0	6.83705
PANK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06684
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902561
OB-17-DQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.355023
cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01541
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.449165
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JEKO1	CCLE Cell Line Gene CNV Profiles	1.0	1.83567
MB-15-ZF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332005
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
YBX1_01_255	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.18444
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein modification by small protein conjugation	GO Biological Process Annotations 2015	1.0	null
CC-55-CD84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286832
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.486679
Perturb_3686_KD_RARRES2_SRP287866	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.46772
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.4502
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.580952
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T2-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.85978
GSE133329_2_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10353540-Table_1.xlsx-HCC1954_AR_vs_HCC1954_A-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.441884
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HEP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63646
OTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65078
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46454
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC39A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08676
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128730_0_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BEND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58495
GSE186647,GSE217288_2_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ACSM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70848
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Placental disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.342
GSE125219,GSE125221_5_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12439337-thnov15p9091s1.pdf-87-ENSG00000162702_ZNF281	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14100_KO_ARID1A_SRP355686	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2852
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02109
NCIH1568	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33091
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RW-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HD-MY-Z	COSMIC Cell Line Gene Mutation Profiles	1.0	null
fusiform gyrus, left, bank of the its	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.879614
GSE150072,GSE169209_4_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8Q9-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8472
U2AF2_02_170	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.01792
Uterine Carcinosarcoma_UCS_TCGA-N5-A59F-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.85927
GSE134615_1_v_0_lats1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186767_1_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254841
hsa-miR-4273	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05142
GSE186471_1_v_0_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.856513
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306788
GSE226285_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NA-16-OJ70_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235843
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5583_KO_NFKBIA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.08246
FADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33485
BFTC905	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79906
ZNF337	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53536
Choriocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
AD-54-FG24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249829
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262139
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NDT 9513727	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10501
all	GWASdb SNP-Phenotype Associations	1.0	0.02862
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279764
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929798
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23728
Perturb_9834_KO_miR31_SRP354225	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.4324
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peroxisomal importomer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.959
ES3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
496100536_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.69749
GSE144453,GSE144454_1_v_0_tfdp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2025	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NR2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.3639
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Perturb_5584_KO_RELA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9428
H3K9me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.79298
ULK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15755
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-GeneID_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53427
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18665
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56023
SLC7A6OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15538
GSE168797_4_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9437
centromedian nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831506
STAT3	ENCODE Transcription Factor Targets	1.0	null
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209005
Perturb_4523_KO_Dpf2_ERP105019	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.40393
UACC893	DepMap CRISPR Gene Dependency	1.0	3.69617
SF172	CCLE Cell Line Gene Expression Profiles	1.0	1.40235
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.750601
PMC4595011-pgen.1005555.s001.xlsx-MITF_UP-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE127790_13_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FAM111A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06758
LAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03479
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.82132
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10501
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08016
SU-DHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22276
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261506
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM190	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22918
Perturb_12186_KD_TP53_SRP065500	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.3768
Oral squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
UACC893	CCLE Cell Line Gene CNV Profiles	1.0	1.68001
RB1_KD_GSE50532_659_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HCC70	DepMap CRISPR Gene Dependency	1.0	2.19559
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
WM-793B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.546
SKMEL19	DepMap CRISPR Gene Dependency	1.0	4.12596
Perturb_16449_KO_MIR22_SRP277508	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.76126
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60176
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29138
GSE130081,GSE130082_4_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TE9	CCLE Cell Line Gene CNV Profiles	1.0	2.48671
PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
MFE296	CCLE Cell Line Gene Expression Profiles	1.0	1.41304
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
colon	HPA Tissue Gene Expression Profiles	1.0	0.84359
TP63	ChEA Transcription Factor Targets	1.0	null
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2722
Perturb_15480_OE_ERG_SRP075246	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.548
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
PATU8988T	CCLE Cell Line Gene CNV Profiles	1.0	1.39539
nucleus subputaminalis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82341
protein ubiquitination	GO Biological Process Annotations 2015	1.0	null
Plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.61
Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07222
RNASE7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59858
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-DLX5_DLX5	Rummagene Transcription Factor Associations 2026	1.0	null
OTULINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50172
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7429-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_0Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.710988
Perturb_3046_KO_Smarcd3_SRP044338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.18693
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8887
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
Papaverine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4719	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_6614_OE_MATR3_SRP132715	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.1981
GSE167474_1_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14385
MKN28	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40547
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2089
HS729	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6165
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM5B	ChEA Transcription Factor Targets	1.0	null
Dipyridamole	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
Baricitinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
Hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ALX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51571
parkinsonism	GWASdb SNP-Phenotype Associations	1.0	0.650754
ARID3A_02_193	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.44057
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31693
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315464
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.68408
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10477
GSE148494,GSE182513_1_v_0_hoxd13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13158
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32534
bone marrow	HPA Tissue Protein Expression Profiles	1.0	1.28886
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6907
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
RVX-208	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2768-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50511
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.871082
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PARP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89058
A549_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113531
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58037
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.90904
Perturb_12196_KD_ERCC5_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE179002_2_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149133
NCIH1755	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67644
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
DAZAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32498
GSE184133,GSE184137_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
prostate	HPA Tissue Protein Expression Profiles	-1.0	-0.884628
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.610492
TNFRSF10D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35131
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.345574
THOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49087
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309894
LOMEGUATRIB	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273419
PMC4595011-pgen.1005555.s001.xlsx-MITF_UP-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EF-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132171
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A4C1-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KNS81	DepMap CRISPR Gene Dependency	1.0	7.61808
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8715
short insular gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.855276
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8664
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-QQ-A5VB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AX-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-F2-7273-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
20035825-TableS7b	GeneSigDB Published Gene Signatures	1.0	null
GSE111247_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_6705_KD_NHERF2_SRP057199	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.0712
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.814085
A549_AT9283_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156762
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9950457-mmc3.xlsx-GRHL2_overexpression_DOWN-gene_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-KDM5B-Unnamed_2_KDM5B	Rummagene Transcription Factor Associations 2026	1.0	null
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209546
SLC45A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7368
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.433316
CDC42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1458
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37028
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7183
JIMT1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32602
Crfk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-1_UCSC_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233183,GSE233187_3_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CE-37-XI06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281332
A549_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137437
A549_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237543
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244584
A549_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174833
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217388
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4293_KO_Tbc1d4_SRP374413	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.34957
NY	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136839
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.442411
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.973782
A549_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280771
Perturb_17706_KO_Platr4_SRP397762	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.57777
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140997_4_v_5_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.8876
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.83942
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71003
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101748_0_v_1_apela_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NDUFB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29845
Gilles de la Tourette syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WM88	DepMap CRISPR Gene Dependency	1.0	2.22588
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3786
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133305
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.15641
496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11895
AC-75-CE67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203321
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KIAA1958	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10464
EZH2	ENCODE Transcription Factor Targets	1.0	null
lung	HPA Tissue Gene Expression Profiles	1.0	1.08644
496100351_FWM_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03009
H3K79me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2022
HCC1897	CCLE Cell Line Gene CNV Profiles	1.0	2.52418
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169658
GSE143692_0_v_1_trim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234262
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2548
PMC11059513-mmc1.xlsx-Supplementary_Table1-Table_S1_The_gene_profile_was_down-regulated_after_HIF1A_was_knocked_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
chr4_188108253_T_C_b38	GTEx eQTL 2025	1.0	2.88258
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
COLO680N	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44875
18787218-tableS1	GeneSigDB Published Gene Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387579
A549_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241923
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16249
A549_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130641
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.634974
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.027355
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.26556
tonsil	HPA Tissue Protein Expression Profiles	1.0	0.710658
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17566_KD_H19_SRP285143	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03901
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
17683608-TableS5	GeneSigDB Published Gene Signatures	1.0	null
CD200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30761
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190458
PMC12285138-13059_2025_3667_MOESM3_ESM.xlsx-A431-Infection_of_A431_cancer_line_with_TP53-R273H-correcting_lentivirus_all_differentially_expressed_genes_p_0_05_fc_2_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154712
A549_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194502
Prostate adenocarcinoma_PRAD_TCGA-G9-6370-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT1197	CCLE Cell Line Gene Expression Profiles	1.0	1.47946
PMC9911396-41467_2023_36178_MOESM11_ESM.xlsx-Sheet1-Genes_in_10kb_vicinity_of_ZBTB12_ChIP-seq_peaks_ZBTB12	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_GSEA_state_markers-AP1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
VPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1725
PMC8851354-Table_5.xlsx-FUS-DDIT3_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_FUS-DDIT3_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Intracellular signaling and cell migration supercomplex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.50964
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.999
BB-11-JI42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24869
A549_Alisertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173288
SARS-ddORF6_72Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.45249
orbital frontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06938
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.8417
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12198_KD_XPA_SRP310546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8168
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33141
DR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00879
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8129
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HM-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AC-37-OZ52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266158
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.375085
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein modification by small protein conjugation	GO Biological Process Annotations 2023	1.0	null
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Triple Negative Breast Neoplasms	DisGeNET Gene-Disease Associations	1.0	null
lymph node	HPA Tissue Protein Expression Profiles	1.0	0.822322
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429489
Plasma membrane	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
HOMER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27775
body of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.81604
H3K9me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
agranular insular cortex (area Iag)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.1746
ZNF322	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42377
A549_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186613
OCIMY5	CCLE Cell Line Gene CNV Profiles	1.0	2.08354
A549_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0274563
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.398
TF-29-QU48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286681
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13894_KD_BRCA1_SRP135799	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.46472
Trophoblast stem cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.644
CLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60585
ANXA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24331
icSARS CoV_60Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.67085
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.849
OE-75-WF43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247493
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3389
TRAPPC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33213
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
HLE	CCLE Cell Line Gene CNV Profiles	1.0	1.56285
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC5013636-ncomms12601-s5.xlsx-LEF1-Groups_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58203
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.951523
Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A9DB-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA	Rummagene Transcription Factor Associations 2026	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
TIPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13242
496100636_FWM_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.6372
PECAPJ34CLONEC12	CCLE Cell Line Gene CNV Profiles	-1.0	-2.26858
SIRT6	ENCODE Transcription Factor Targets	1.0	null
CAL851	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37954
KYSE510	CCLE Cell Line Gene CNV Profiles	1.0	1.35158
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.08368
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226249_0_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Testicular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.671
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.53295
SCC-25	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.61078
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JADE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08251
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.900234
HA1E	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4534
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IC-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
VA-92-QP54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276346
A549_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138956
superficial layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.21969
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RO-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240931
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.586989
SET2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NVP-BEP800	DeepCoverMOA Drug Mechanisms of Action	1.0	0.95
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986129
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ubiquitin-like protein ligase activity	GO Molecular Function Annotations 2023	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.556762
b95.8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
PMC10353540-Table_1.xlsx-HCC1954_AR_vs_HCC1954_A-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.45858
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1594
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.842202
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18627
SMG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56684
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343802
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F0-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201352
GSE141453,GSE141454_0_v_4_card11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TV-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29386
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8144
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902561
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
KALS1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48069
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9466
CCDC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29037
NCIH1092	DepMap CRISPR Gene Dependency	1.0	2.59032
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0644
Choriocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42635
GSE120200,GSE127269_1_v_2_asxl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AT9283_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163222
GSE133213_6_v_5_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13229_OE_Klf5_SRP341620	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.52072
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
GRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36942
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7825356-8844261.f3.docx-53-SPEN_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8851354-Table_2.xlsx-Genes_reg_by_FUS-DDIT3-Supplementary_Table_2_Genes_significantly_regulated_by_FUS-DDIT3_expression_in_HT1080_cells_adjusted_p-value_0_05_and_log2_Fold_change_1_or_-1_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38143
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013791
Lyf-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22529
PMC5259899-13287_2016_455_MOESM2_ESM.xlsx-Down-regulated-Supplementary_Table_S2_Down-reguated_genes_expression_in_MESP1_negative_cells_MESP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NUDT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32481
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06979
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7069-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.21864
M14 melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.35
FOXP1_01_88	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.4891
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0801
GSE116580_0_v_1_smug1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor-sensory cortex (samples)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.874314
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.52
CA-66-FY97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218246
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
SLR20	CCLE Cell Line Gene Expression Profiles	1.0	2.00357
placenta	HPA Tissue Gene Expression Profiles	1.0	2.24804
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MRK-NU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE128099,GSE128159_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Perturb_12599_KD_Gatad2b_SRP366371	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.47558
Rectum adenocarcinoma_READ_TCGA-BM-6198-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23728
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.77295
496100472_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.54265
SUPT5H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.8859
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929798
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.044171
Perturb_2689_KD_BMOR_SRP344304	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_4616_KD_Rfx1_SRP231452	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.76442
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.521625
PMC9583506__F2	PFOCR Pathway Figure Associations 2024	1.0	null
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.018985
NCIH1838	CCLE Cell Line Gene CNV Profiles	1.0	1.78958
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16249
Perturb_8908_KD_CCDC144NLAS1_SRP135858	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.1991
GSE210662_2_v_0_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214291
SUMO2	Pathway Commons Protein-Protein Interactions	1.0	null
CD-20-GE75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331373
Desvenlafaxine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
Perturb_6615_OE_MATR3_SRP132715	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.86363
NA-16-OJ70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202482
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HAUS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20167
Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MKN74	CCLE Cell Line Gene Expression Profiles	1.0	2.6549
A549_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256902
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.832342
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166202
LS123	DepMap CRISPR Gene Dependency	1.0	2.07208
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PDPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10665
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.928879
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04883
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.93898
Rectum adenocarcinoma_READ_TCGA-AF-6655-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7222
Lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Immune system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53551
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266441
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11773
P63-26484246-CHIP-SEQ-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836034
TASK1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014062
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01233
RBM22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11859
GET3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01499
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4759
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Q-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72271
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.3691
JHH6	CCLE Cell Line Gene Expression Profiles	1.0	1.35953
A549_Azacitidine_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00826031
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7709
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458344
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A723-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF277	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25878
ntera2	HPA Cell Line Gene Expression Profiles	1.0	1.1545
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6484
Trichorhinophalangeal syndrome type II	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.605
ulnar-mammary syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
icSARS CoV_48Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	3.02021
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.840579
CP-673451	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.6
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4595
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.913616
KDM4E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08999
S0-EE-XMXE_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258264
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
OSI-027	DeepCoverMOA Drug Mechanisms of Action	1.0	0.78
ARX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22198
PMC9314667-Table_1.xlsx-Regulons-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
AA-94-TU18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.359315
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229698
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246716
STAT3-24763339-IMN-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53316
Dynein axonemal particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.636
Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.969997
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210941
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCAPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21032
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Sotrastaurin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.47
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03781
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160796
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61279
DU-4475	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08501
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MRGBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04604
chromosome, subtelomeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.323
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CBC32 (POLDIP3)	NURSA Protein Complexes	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HCC78	DepMap CRISPR Gene Dependency	1.0	2.54213
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42704
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03735
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.576
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_12_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
PSIP1_Deficiency_GDS2883_633_human_T-cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152483
CF-24-KQ98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218445
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160576
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7968
NCIH1155	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53672
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373458
Perturb_15238_KD_TINCR_SRP082178	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.04006
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.849164
E2F4	ENCODE Transcription Factor Targets	1.0	null
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.0799
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Primary effusion lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00818
Tafluprost	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
GSE144500_7_v_6_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gonadal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8063
NCI-H838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-0.884628
Brain Lower Grade Glioma_LGG_TCGA-DH-5142-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235550_1_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33274
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3799
SOX3-22085726-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_17484_KD_RN7SK_SRP298839	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.61011
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hereditary spastic paraplegia 56	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral septal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17138
MM485	DepMap CRISPR Gene Dependency	1.0	2.89635
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
DC-22-OP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.440631
H3K9me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5029_KO_4930500J02Rik_SRP072189	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.53074
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51093
Eye-conjunctival epithelial cell	Tabula Sapiens Gene-Cell Associations	1.0	5.97965
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MOLT-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
inner CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28321
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3492
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23216
ZFYVE19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03094
HSCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18912
HT-1197	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CDR2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00605
JA-63-WB39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225242
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.52539
PTPN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06856
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160613
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EN2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.406
SKES1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.41165
IZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01989
GTF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11315
18318837-TableS2	GeneSigDB Published Gene Signatures	1.0	null
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.105363
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.48304
Triple-Negative Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10679662-mmc2.xlsx-NC-D5-ZEB2-siRNA-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.92365
WDR74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3565
protein modification process	GO Biological Process Annotations 2015	1.0	null
A549_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133539
EMILIN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.828
BE-59-WG31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216614
A549_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109515
MM253	DepMap CRISPR Gene Dependency	1.0	2.60139
Perturb_6296_KD_NIPBL_SRP221332	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.8773
Adrenocortical carcinoma_ACC_TCGA-OR-A5LB-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer III of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07274
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21137
Prostate adenocarcinoma_PRAD_TCGA-EJ-7312-01B-21R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YC-45-JD42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212904
Iclaprim	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.58
response to organic substance	GO Biological Process Annotations 2015	1.0	null
ubiquitin-like protein ligase activity	GO Molecular Function Annotations 2025	1.0	null
OECM-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.887
Hs-578Bst cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
brain	GTEx Tissue Gene Expression Profiles	1.0	1.34225
a549	HPA Cell Line Gene Expression Profiles	1.0	1.14587
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
496100547_HIP_no dementia_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41873
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58212
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PNMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05762
FAM177A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43188
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.920176
HME1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.479949
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04981
A1207	CCLE Cell Line Gene Expression Profiles	1.0	1.67391
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.476485
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TU-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01002
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GPR143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33293
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7252-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929798
Rectum adenocarcinoma_READ_TCGA-EI-6506-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139189
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.05796
NC-52-AG88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311244
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37213
medial intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.938329
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.062353
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
response to acid chemical	GO Biological Process Annotations 2015	1.0	null
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200539
GSE164494_1_v_2_rab22a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.47504
Lung adenocarcinoma_LUAD_TCGA-91-6830-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15482_OE|KD_ERG|EWSR1_SRP075246	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.0605
lateral portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18976
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00227
HT55	DepMap CRISPR Gene Dependency	1.0	2.41691
Adrenocortical carcinoma_ACC_TCGA-OR-A5K8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EIF3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59783
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208599
H3K9me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.47362
small intestine	GTEx Tissue Gene Expression Profiles	-1.0	-0.937483
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.390523
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QQ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9314667-Table_1.xlsx-Regulons-IRF7_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.71077
GSE241701_4_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100497_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.6666
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303633
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421579
CAOV4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.04769
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3991
PMC4944136-srep28995-s2.xls-NOBOX-gene_NOBOX	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03505
A 922500	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.09
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30867
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54197
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PHOX2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64817
A-Vietnam-1203_CIP048_RG3-2004(H5N1)_7Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.59474
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14336
EF-85-DA07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346143
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-89-HC56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.473546
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.968495
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319651
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.397
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Small ribosomal subunit processing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.933
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347944
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
dh15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.293
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38142
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.1108
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
BL2249 (HPS5)	NURSA Protein Complexes	1.0	null
647V	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36408
AB-18-YN11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200454
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.009
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.28886
SNU119	CCLE Cell Line Gene CNV Profiles	1.0	1.80576
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182179_2_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JA-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5893-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AVPI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22718
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.398
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9515
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10584
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.534469
ID-00-IC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314424
A549_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231653
response to retinoic acid	GO Biological Process Annotations 2015	1.0	null
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1746
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37359
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COV362	CCLE Cell Line Gene CNV Profiles	1.0	1.58832
Testicular germ cell cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.725
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.593335
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4936
abnormality of extrapyramidal motor function	GWASdb SNP-Phenotype Associations	1.0	0.650754
nucleus of diagonal band	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.963079
Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.48505
Undecanoic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2126
RH30	CCLE Cell Line Gene CNV Profiles	-1.0	-1.97894
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221997
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_5571_KO_RELA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.49214
mRNA_DLX3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
A549_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262641
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_14905_KD_LIN41_SRP032743	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.15566
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6679
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.61704
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.576707
A549_Bosutinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125297
CHEMBL1436068	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
MAP3K1_knockout_245_GSE39240	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.3395
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
liver	HPA Tissue Protein Expression Profiles	-1.0	-0.884628
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_3Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.40665
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
496100535_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.67409
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.26978
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.97651
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MLL3/4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.941
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.935938
PMC4162954-12864_2014_6430_MOESM3_ESM.xlsx-2102Ep-Genes_deregulated_in_2102Ep_cells_after_SOX2_knock-down_FDR-corrected_P-value_0_05_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N5-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QB-88-PG52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219687
disease	GWASdb SNP-Disease Associations	1.0	0.024611
Brain capillary endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1105
Prostate adenocarcinoma_PRAD_TCGA-VN-A88O-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.933925
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.91979
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-44-LW45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298617
SW1783	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88499
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.579724
Fetal Lung	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.953281
AD-52-UZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200233
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42163