association	dataset	threshold value	standardized value
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.494264
7514_RPS25_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.539849
MCF7_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123923
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209506
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238438
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6189
Cingulate cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.477
AA-98-MW52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257599
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0238
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210249
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5'-3' exonuclease activity	GO Molecular Function Annotations 2025	1.0	null
K562_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162604
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481901
QE-18-WG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22093
Forelimb muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.064
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SEPTIN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93847
GSE221932,GSE222115_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189772,GSE189773_0_v_5_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285908
GSE193282_2_v_0_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242676
DA-58-LZ09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27234
MCF7_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190694
SUZ12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.139
CF-03-QN99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226661
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337454
BEC	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
K562_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230747
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
CC-90-EX35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224496
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157682
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118817
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33572
AC-28-RT00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.9123
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.7352
SW626	DepMap CRISPR Gene Dependency	1.0	2.98094
MCF7_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179738
RABL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35408
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE197630_1_v_0_ruvbl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121319_1_v_2_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
APOBEC3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07817
GSE149075_2_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EIF2AK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53111
GSE111247_11_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18041
HSQ89	DepMap CRISPR Gene Dependency	1.0	2.00786
CB-24-FA25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34905
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264148
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Erythroid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.622
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06492
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434528
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.5048
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-58-PW17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.39718
BC-43-JW95_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358142
Inferior frontal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.48
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ACSBG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86662
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189287
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184515
GSE71385_1_v_2_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218253
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016396
AF-80-GK24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330755
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.1075
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13164
AD-86-OB87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.45791
PMC5369016-12885_2017_3206_MOESM3_ESM.docx-0-MEF2B_MEF2B	Rummagene Transcription Factor Associations 2026	1.0	null
K562_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166347
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
QA-34-PH05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.63821
Rennet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.673
MCF7_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158075
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-13-OQ01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.645341
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
TNFRSF12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47742
BD-48-ZT65_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303412
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_11_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8315
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	139.484
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.03062
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Posterior lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
A549_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160698
MB-32-LQ97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331216
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160463
UBXN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9156
CB-02-XL81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.769766
PMC4694980__F6	PFOCR Pathway Figure Associations 2023	1.0	null
Brain capillary endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
UPCISCC029A	DepMap CRISPR Gene Dependency	1.0	2.0052
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04806
BC-00-YH62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.07517
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.352
496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00758
ZNF618	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34844
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.94914
WB-54-WD35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.577161
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338157
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124016
MCF7_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136009
5'-3' exonuclease activity	GO Molecular Function Annotations 2023	1.0	null
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pleural mesothelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3332
PMC10913870-pr3c00632_si_001.pdf-135-ZBED6_ZBED6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025072
SPECC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08687
sno(s)RNA-containing ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
NCIH292_LUNG	CCLE Cell Line Proteomics	1.0	2.33348
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.6891
ID-70-SM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257527
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TIGD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15069
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.70533
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.50854
MCF7_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138709
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.675323
8431_SRSF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.575885
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515962
MCF7_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213014
PMC12756533-mmc1.pdf-30-PKNOX1_PKNOX1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140314
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MC-51-BT07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39421
A549_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181684
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4881
VD-88-MW70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307237
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.673
GSE210580_5_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IA-27-CK10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.451259
Leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6964
rRNA metabolic process	GO Biological Process Annotations 2023	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.32542
METTL21A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16304
WB-54-WD35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294689
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2574
MCF7_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218021
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.19
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402544
DB-56-XL71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07355
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195559_3_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7086
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.471
WDR89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19429
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142314
Insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.689
BB-10-PR06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231439
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314801
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7792
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.882791
DC-49-EJ23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.940356
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021843
JA-79-II25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214842
MCF7_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228316
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S01_LF_C1_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Caudate nucleus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.52
KDM4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24517
4523_LAS1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.5304
7839_SF3B5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.560071
K562_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203654
AC-36-SY22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.429535
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211308
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.997559
7431_RPL10A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557723
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.0586
G415	DepMap CRISPR Gene Dependency	1.0	2.19225
FF-22-NB12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.761583
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235234_2_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177144
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.70996
JA-85-SW39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.691974
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6133
SW1116	DepMap CRISPR Gene Dependency	1.0	2.22671
Avian pallium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.759
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EB-67-WB79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25232
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176063
BB-86-BE39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239755
MCF7_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252227
OR2B6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85325
3'-5' exonuclease activity	GO Molecular Function Annotations 2025	1.0	null
ONE58	DepMap CRISPR Gene Dependency	1.0	2.40203
PMC4346630__F10	PFOCR Pathway Figure Associations 2024	1.0	null
SMAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.92081
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.639143
AD-58-PW17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.57584
AMOTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39445
CORL311	DepMap CRISPR Gene Dependency	1.0	3.083
DC-59-NQ20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209434
Parahippocampal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.733
Acute megakaryoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.466
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218615
GSE229580_0_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.687246
EE-02-BO83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.515276
Adductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.975
rRNA catabolic process	GO Biological Process Annotations 2023	1.0	null
HB-06-WU12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385772
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253536
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186377
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390352
BTBD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03515
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-38-UW72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264963
FB-33-LI31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06052
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.398407
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160764
A549_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015385
PDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93388
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26627
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	5.95051
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29015
MCF7_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015885
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206516,GSE206518_2_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247537
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-04-QG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343184
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.866339
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
SF268	DepMap CRISPR Gene Dependency	1.0	2.34558
EOL1	DepMap CRISPR Gene Dependency	1.0	2.5273
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014983
6537_POLR1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569564
BE-38-UW72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340257
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
ATF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09307
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
S0-EE-Y737_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22391
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228199
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9061
AB-80-CK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261215
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.508039
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
PMC8384902-mmc2.xlsx-4_NEUROD1_high_subtype-Gene_Symbol_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null
Binocular vision disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
t30-blood-rna_male_8w	MoTrPAC Rat Endurance Exercise Training	1.0	5.73277
BB-86-BE39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200871
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253924
AE-22-QI24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489471
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6492
HA-32-YH61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.673366
EA-07-RB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231205
MM485	DepMap CRISPR Gene Dependency	1.0	2.10528
GSE193588_1_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM258	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49467
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4268817-13059_2014_551_MOESM3_ESM.xls-Sig_change_all__10_tsv-Additional_file_3_List_of_genes_with_signficant_expression_changes_in_any_of_the_KD_conditions_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DA-10-GX45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.901263
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.852552
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.915518
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.565878
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300478
MCF7_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213205
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189245
Midbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.777
WM88_SKIN	CCLE Cell Line Proteomics	1.0	3.75793
GSE116580_0_v_1_smug1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016542
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Proteasome storage granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.37
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7942
GSE199606_2_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-12-PP61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245098
EE-02-BO83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250683
PMC8758144-elife-74272-supp3.xlsx-AP2_REP1-GeneName_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.139
MCF7_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167945
A549_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143571
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.745891
Glume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.233
MCF7_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018978
GSE157049,GSE157051_6_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE215351,GSE215794_7_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EC-98-YS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416756
Endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147240_3_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
TB-06-VB30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.455494
MCF7_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193633
Neostriatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.52
DA-10-HD17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372329
AA-52-JS03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301868
MCF7_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117546
AB-70-GR31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268663
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146797
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.47286
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7609
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155021
PMC10534007-Table_2.xlsx-S4_unique_down_MSC_V-745_elements_included_exclusively_in_VM-CUB1_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240027,GSE240030_1_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1993	DepMap CRISPR Gene Dependency	1.0	2.50103
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.428351
SLC19A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07015
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4856
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2044_DBR1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50756
MCF7_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00986233
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.798059
PMC4694980__F6	PFOCR Pathway Figure Associations 2024	1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334525
QD-57-GT11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200139
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.516657
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8742
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310153
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.404593
GSE248501_1_v_0_mst1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.655086
Biceps	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.848
ESS1	DepMap CRISPR Gene Dependency	1.0	3.19372
Occipital lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.416
Internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
MYO9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07794
PMC7642293-41467_2020_19328_MOESM11_ESM.xlsx-20191030_AA_iTop3Summary-GN_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
6118_PCED1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.897472
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30983
NP8	DepMap CRISPR Gene Dependency	1.0	2.38374
JD-87-KA71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224753
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195194
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
PMC4346630__F10	PFOCR Pathway Figure Associations 2023	1.0	null
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198872
A549_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0264852
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276299
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.44056
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289043
PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HDX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29039
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
PMC8027210-41423_2020_615_MOESM5_ESM.xlsx-CT4-_CCR6_RORC-gene_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
KC-26-JQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.756959
UBE2H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49311
CA-48-JF51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.618467
CE-37-XI06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272976
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157557,GSE157559_1_v_0_parp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BA-19-VU85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217886
Pleural mesothelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.901
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ncRNA catabolic process	GO Biological Process Annotations 2023	1.0	null
GSE201217_3_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06107
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183074
K562_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136003
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.1259
FE-06-GR60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.604882
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.9242
PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
HC-76-HU27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338809
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9424_TUBG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.819185
K562_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170845
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130702
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374209
2276_DNAJA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507267
YC-45-JD42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416793
MCF7_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142473
exonuclease activity	GO Molecular Function Annotations 2025	1.0	null
MCF7_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111105
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.624
IFI6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0924
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152271
GSE144838_7_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_8_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.92143
Pancreatic islet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.664
Trophoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.803
HA-17-MS45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203804
TMEM89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72696
PD-11-LM65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347669
5729_NOC2L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51345
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.499363
RNA phosphodiester bond hydrolysis, exonucleolytic	GO Biological Process Annotations 2023	1.0	null
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162919
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219355
8223_SNRPA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.767725
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.550927
CCDC137	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23167
IE-80-DC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223126
DB-56-XL71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25117
QA-34-PH05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.868532
Cerebral peduncle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
TE-26-XS06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.676164
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.68768
SKMEL24	DepMap CRISPR Gene Dependency	1.0	3.4019
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.510793
ID-90-NM43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481451
AA-87-EI21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.620957
OB-15-UL37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.18887
H-508	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
Endocrine pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.664
MCF7_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143457
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599405
MCF7_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178881
HEC265	DepMap CRISPR Gene Dependency	1.0	3.21839
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.736581
YD15	DepMap CRISPR Gene Dependency	1.0	2.10737
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.872
UE-76-JL04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.506231
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.539661
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204089
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469952
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCC142	DepMap CRISPR Gene Dependency	1.0	2.14012
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCCMPNST1C1	DepMap CRISPR Gene Dependency	1.0	2.13105
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146247
TUBA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40287
MOLT-4 cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
CXXC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2368
Basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.759
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SORBS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13527
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1667
KB-88-OR49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217416
MCF7_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126568
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.805
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	146.04
PMC5998130-41467_2018_4619_MOESM7_ESM.xlsx-specificity_NCOA3-Gene_Name_NCOA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4736761__F4	PFOCR Pathway Figure Associations 2023	1.0	null
AD-58-PW17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.48974
3123_FNBP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.726531
BD-50-HU68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255983
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.36771
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019386
TAF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56846
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.7763
SDR39U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2514
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.04441
MCF7_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124399
KE-91-GT92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243707
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229687
MB-49-LL22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2645
K562_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020247
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
Cellular bud neck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.283
RABGGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42029
Narcissistic personality disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.442
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450081
SNU668	DepMap CRISPR Gene Dependency	1.0	2.72921
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.515489
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01611
GSE102870_3_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bacteroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
MCF7_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137473
PMC6488577-41598_2019_43010_MOESM2_ESM.xlsx-Proteingroups_MBD3_pos-Gene_names_MBD3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173201_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244224
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.875719
Hfl	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
A549_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123591
PCDHB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00292
PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_DE_Targets-Unnamed_2_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100646_TCx_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32202
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24031
CB-02-XL81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.908659
MCF7_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0283763
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.47336
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.420215
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Parietal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.252
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.518992
GI1	DepMap CRISPR Gene Dependency	1.0	2.65602
AF-00-QK19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.90433
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.2349
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08735
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.805
LARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2047
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134166
ODR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02445
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cellular bud	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.269
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66541
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162393
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
EF-62-IO23_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204916
ATOH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11175
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.1135
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13839
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.440884
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.882462
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183271_4_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6379364-41598_2018_37489_MOESM2_ESM.xlsx-Sheet2_DESeq_MSC_vs_fibroblast-DESeq_MSC_vs_fibroblast_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UC-00-QA88_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272645
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.67176
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153832
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-10-GX45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.558375
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6897
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.0
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-42-HT01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287608
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.50764
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM30B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53986
K562_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148072
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14442
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95685_4_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12289921-41467_2025_62099_MOESM4_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399543
PMC8307416__F5	PFOCR Pathway Figure Associations 2024	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.46544
RF-36-EI47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241618
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51287
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218254
FASTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2174
GSE127205_1_v_0_asf1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.480294
Parenchyma	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.731
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	1.0	null
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.759
AA-48-XT80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.80662
MCF7_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134806
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.72393
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.30597
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.4139
RTCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19888
S0-EE-Y6WJ_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2072
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336219
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3961
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.135
WB-82-EL69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250424
Posterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.591
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.2947
CHLA10	DepMap CRISPR Gene Dependency	1.0	2.80019
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79245
JA-85-SW39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3554
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6880099-mmc1.docx-0-Table_S1_Protein_targets_of_6-OHDA-PEG3-yne_identified_by_mass_spectrometry_1_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
Thalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.592
MUTZ8	DepMap CRISPR Gene Dependency	1.0	2.1074
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211383
MCF7_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184297
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Anterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.462
PBRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02122
Middle temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.831
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE150049_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-37-XI06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301342
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HAND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1982
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25486
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100891
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357864
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.651069
BC-75-FA82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248672
A549_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137532
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AU565	DepMap CRISPR Gene Dependency	1.0	3.45863
Acute lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
A549_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147262
AA-88-PJ86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.879671
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
2122_DDX46_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526173
A549_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135336
K562_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149049
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
TA-19-YA45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35705
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.35077
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9402
CDC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21815
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1935
Carbamazepine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
A549_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206997
HD-29-PZ41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30758
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00793
Superior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.815
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.301
HB-24-GP45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281298
BB-77-QQ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280245
7830_SF3A1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.662526
Anterior commissure	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.14
2765_ETV5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555412
K562_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0299616
PMC9397613-can-21-1692_supplementary_table_s8_-_12_supps8-12.xlsx-S9_sgRNA-TP53_enrichment-Supplementary_Table_9_sgRNAs_correlating_with_TP53_sgRNAs_enrichment_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139102
A549_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014451
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.790458
MCF7_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245586
Trigeminal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.031
Tinea cruris	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
Blood cancer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
SMARCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83904
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33358
Tinea unguium	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.602
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.9103
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KC-26-JQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341865
AF-16-IB77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211345
MCF7_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254019
XE-29-LT20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224642
Cytosolic small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.839
AC-44-UR36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469157
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.56646
K562_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154029
TA-19-YA45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24812
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
TIMM44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14526
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.814078
BC-13-OQ01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22175
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178658
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9982
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-92-LS83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203215
Telomerase holoenzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.58
MCF7_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162718
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEx Ovary 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	5.57666
MCF7_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0386246
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
FF-90-JK74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01047
PC-44-DH10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238001
PMC10290283-biol-2022-0622-sm3.pdf-325-TCF7L1_TCF7L1	Rummagene Transcription Factor Associations 2026	1.0	null
STUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25047
MCF7_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159147
Myelencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.522
K562_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172232
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.74079
MCF7_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160042
NCIH2286	DepMap CRISPR Gene Dependency	1.0	2.64436
FB-29-KC76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230162
PMC12486367-Supplementary_Data2.pdf-162-GPBP1L1_GPBP1L1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB-80-IM48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201333
PMC12721900-jci-136-187998-s161.xlsx-Flag-ETS1_vs_vector-Gene_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
TRMT10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1794
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4492
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539028
GC-08-VP20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292104
K562_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186451
UE-90-AA63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20826
PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
C15orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1472
GSE138945,GSE138947_0_v_1_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187279
PMC9314667-Table_1.xlsx-Regulons-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44482
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
Superior frontal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.094
XD-03-FM54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211576
GSE181821_1_v_4_mov10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.02645
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438464
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287081
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.75374
496100359_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08106
MCF7_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125261
496100657_FWM_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.54638
A549_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189409
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Motor cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.58
FB-56-SR65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.300365
Temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.907
PMC12706077-44318_2025_598_MOESM21_ESM.xlsx-Dataset_EV19-hKidney_TPP-PISA-Genes_ZNF568	Rummagene Transcription Factor Associations 2026	1.0	null
RD-92-QT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360402
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243602
Basis pedunculi cerebri	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.984
OC-71-BZ81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.96205
KB-49-NF63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486927
MCF7_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107564
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446278
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11146
6795_PRPF38B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.776423
A549_AT9283_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00965854
DF-95-CY55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202762
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163242
496100366_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.52537
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584746
Paracentral lobule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.514
WBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36262
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.15467
XC-88-ZM66_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221597
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
AB-26-BE29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213848
GSE143782_3_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
RERFGC1B	DepMap CRISPR Gene Dependency	1.0	2.75786
MCF7_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138006
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-02-XL81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207311
Nucleus lentiformis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.394
MCF7_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128784
ME-62-IQ37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344796
PMC9001660-41467_2022_29173_MOESM5_ESM.xlsx-Fig_2g_STAT3_DEGs-gene_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
HeLa-S3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.007
MCF7_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00948329
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452418
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311193
SOX10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7032
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147240_3_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EC-98-KI28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283442
DA-17-XI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371269
HSC3_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	3.06541
MCF7_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174611
DB-41-IH69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.552761
GS-9620	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
K562_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164396
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GB-84-KP45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215881
ZNF844	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42924
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.38618
HEXIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17715
CC-18-YW57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.20883
A549_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147077
GSE199606_2_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01564
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
2328_DOHH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528183
S0-EE-Y79N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448391
NCIH929_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.75351
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.507758
MCF7_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129788
PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.624
DB-88-VW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4584
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-75-FA82_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524293
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209782
PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_6_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
GSE157049,GSE157051_6_v_4_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143222
rRNA catabolic process	GO Biological Process Annotations 2025	1.0	null
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.695828
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8453
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CA-68-TC79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.888906
MCF7_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122458
LRRC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45431
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158607
ZNF415	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23619
BE-71-AV63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235691
94T778	DepMap CRISPR Gene Dependency	1.0	2.10957
CAL62	DepMap CRISPR Gene Dependency	1.0	2.11084
ZB-33-MZ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.501209
PMC8550965-41375_2021_1235_MOESM2_ESM.xlsx-HNT-34_RUNX1-Gene_names_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328559
Olfactory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.144
WF-85-JN16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243999
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4999
MCF7_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123386
Globus pallidus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.979
MCF7_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135567
UBALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04895
Anastrozole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583762
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256084
ep16	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.66
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231139
GSE216538_1_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tricuspid valve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
SUDHL8	DepMap CRISPR Gene Dependency	1.0	2.89987
Leukemia cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
SKMG1	DepMap CRISPR Gene Dependency	1.0	3.3243
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WSUNHL	DepMap CRISPR Gene Dependency	1.0	2.49019
DB-07-WB29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356524
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153854
AA-52-JS03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517819
A549_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155871
INSIG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91426
NCIH1944	DepMap CRISPR Gene Dependency	1.0	2.2947
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-30-CR11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359243
Embryonic brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.869
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KC-26-JQ92_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.660818
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.15
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375348
BC-00-YH62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.832816
BB-77-QQ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.407817
VA-48-RJ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208495
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.843372
Neostriatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.315
MCF7_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158191
exonuclease activity	GO Molecular Function Annotations 2023	1.0	null
507_ARL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.603604
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.863
Protein phosphatase 4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.316
MCF7_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133492
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JJN3	DepMap CRISPR Gene Dependency	1.0	2.09975
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.4375
GABRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09392
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29647
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014406
GSE154577_6_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12909843-41467_2026_68388_MOESM4_ESM.xlsx-fig3g-up-regulated_gene_expression_in_OTX2-KO_8CLCs_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
1175_CAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516585
EXOC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.002
CE-95-YX02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.39165
PB-40-YB26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208288
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.3965
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6302
Lymphocytic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	133.233
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.499425
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184401
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9246
GSE193282_3_v_1_cd44_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.9865
MCF7_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238822
AC-28-RT00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.47413
A549_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164058
DOHH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3886
FE-29-XM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289473
AB-30-CR11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.855854
MCF7_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015331
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.1565
PMC3895605__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Exoribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.895
VMCUB1	DepMap CRISPR Gene Dependency	1.0	2.28771
PMC3895605__F2	PFOCR Pathway Figure Associations 2023	1.0	null
AA-52-JS03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30164
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
TFB1M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50846
PMC6996923-elife-46981-supp4.xlsx-KO_Up_Only_Vs_OCT4-Column_ID_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.0331
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6875
HF-91-IU60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248407
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226395
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IE-80-DC24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603165
KBTBD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74608
GSE202587_1_v_0_xrn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8058
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106565
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MCF7_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156299
PMC6379364-41598_2018_37489_MOESM2_ESM.xlsx-Sheet2_DESeq_MSC_vs_fibroblast-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Molindone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279033
Olfactory bulb	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.475
MCF7_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0281104
PMC5675827__F7	PFOCR Pathway Figure Associations 2024	1.0	null
5747_NOP16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574916
DEL	DepMap CRISPR Gene Dependency	1.0	2.3878
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.973135
Cerebral gyrus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.477
GSE114993,GSE118452_2_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149075_2_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-10-VU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25016
U118MG_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	4.03034
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.782904
MCF7_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192341
AF-12-IW93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313354
MIH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.445
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.11495
HA-17-MS45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427238
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
7431_RPL10A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.561517
CCHCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04615
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
496100571_FWM_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34991
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.759
ESPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03573
TRIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2189
BC-84-BQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.381761
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2003
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230744
Mitral valve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	1.0	null
JB-63-NV02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210989
Striate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.921
FD-25-KX07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477133
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147240_3_v_1_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244991
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE186280_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.919608
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.717468
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.537563
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143585
PYM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15618
OVMANA	DepMap CRISPR Gene Dependency	1.0	2.54753
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.62309
K562_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187222
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2898
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221314
Cingulate gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.741
Vagina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BC-13-OQ01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.99404
EP400	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2742
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-92-TW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274952
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EF-99-HJ48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253237
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148614
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.463111
NCIH1568	DepMap CRISPR Gene Dependency	1.0	2.76961
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325068
DD-30-SX80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.764125
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.01241
K562_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015357
Dorsal lip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.763
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134302
K562_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273449
GSE200352_4_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IC-79-JZ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228121
MCF7_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215688
CF-42-OS28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.18097
ZBTB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47519
EE-98-PF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532972
GSE171269_1_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-54-MA35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.422549
KKU213	DepMap CRISPR Gene Dependency	1.0	2.96681
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5918
MCF7_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184275
EF-85-DA07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230492
DPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23124
SG231	DepMap CRISPR Gene Dependency	1.0	2.04039
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2741
BC-75-FA82_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247669
NB-58-SA13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225662
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216037
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248913
SD-82-GT69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.783808
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150038
Symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
MCF7_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017627
MCF7_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172352
TMEM97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27617
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.581888
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE183271_5_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
VA-92-QP54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.79321
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42421
GSE86507,GSE86509_7_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoblastoid cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pulmonary emphysema	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540462
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.71399
Middle frontal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.275
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163642
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.25182
BE-92-TW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.883136
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JURLMK1	DepMap CRISPR Gene Dependency	1.0	3.01369
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70666
Adrenal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.38
Pilocytic astrocytoma of cerebellum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
ATP6V1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06133
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5912
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20474
EVSAT	DepMap CRISPR Gene Dependency	1.0	2.70542
Caudate putamen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.451
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.16
GSE198971_0_v_2_ncor2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PA-15-CP52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215689
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03886
Occipital pole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.026
BA-53-FM66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.740237
DA-23-TZ42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287986
PANC1	DepMap CRISPR Gene Dependency	1.0	2.07916
MCF7_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232232
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.570647
SCML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18365
GSE80537_5_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMM1	DepMap CRISPR Gene Dependency	1.0	2.07723
GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.833865
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DOLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31791
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.10074
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527532
FD-48-HZ39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225189
TMEM127	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02937
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277316
Neural arch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
ID-90-NM43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12924
BF-44-HD37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277068
Leaf tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
GSE190555,GSE190557_2_v_3_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
AA-68-OJ16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31956
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.787209
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1208
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512056
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7558
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219046
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
SOX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47271
L-NIL	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
KU812	DepMap CRISPR Gene Dependency	1.0	2.51123
IE-49-AI35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.381346
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-33-LI31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.53859
CCLP1	DepMap CRISPR Gene Dependency	1.0	2.65671
WB-82-EL69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.640287
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-826-ENSG00000197044_ZNF441	Rummagene Transcription Factor Associations 2026	1.0	null
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.98857
AF-83-BX08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299378
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.839678
GB-11-TA37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264299
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
OC-21-IP52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211051
AA-94-TU18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314626
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400964
Hamstring muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
301_ANAPC10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.580514
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HB-87-YY34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.633674
DF-85-QA87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24385
CC-93-RP38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202863
PARP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4937
GSE240027,GSE240030_1_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3903
AC-28-RT00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12358
BDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46586
TT1TKB	DepMap CRISPR Gene Dependency	1.0	2.34966
MCF7_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216688
MCF7_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275125
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
A549_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127622
OC316	DepMap CRISPR Gene Dependency	1.0	2.35968
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7406
MOGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30721
GE-63-WI86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227228
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE240027,GSE240030_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169571_5_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-09-JG96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269497
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136027
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
LMSU	DepMap CRISPR Gene Dependency	1.0	2.77385
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.759
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
GC-46-AX49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290937
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.555138
PMC12079334-ADVS-12-2501734-s002.pdf-188-ENSG00000188868_ZNF563	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12211054-spectrum.00100-25-s0002.pdf-13-ZNF595_ZNF595	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18908
KIZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49748
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22329
MCF7_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241941
NCCMPNST2C1	DepMap CRISPR Gene Dependency	1.0	2.47487
MCF7_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150858
RNA phosphodiester bond hydrolysis	GO Biological Process Annotations 2023	1.0	null
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304613
SUDHL1	DepMap CRISPR Gene Dependency	1.0	2.39229
AD-55-WK61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323708
A549_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145231
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MED19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0063
496100653_PCx_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.75629
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179898
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S12_LF_C1_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
L1236	DepMap CRISPR Gene Dependency	1.0	2.47013
CE-69-FD64_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210314
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171776
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276688
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.602954
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
WM1799_SKIN	CCLE Cell Line Proteomics	1.0	6.8215
T-lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191878
C2BBE1	DepMap CRISPR Gene Dependency	1.0	2.91275
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186986
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.914536
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
MA-58-RR04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.703056
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Amygdala	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.759
GD-71-OU80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352325
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HA-32-YH61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.853881
KPNYS	DepMap CRISPR Gene Dependency	1.0	2.79828
Tricuspid valve insufficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.51184
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01001
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Thymus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.931
A549_FLLL32_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146384
WB-82-EL69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344658
K562_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140881
9396_TTF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.5438
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263237
105_ACTG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.715324
KELLY	DepMap CRISPR Gene Dependency	1.0	2.91482
MCF7_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227028
KYO1	DepMap CRISPR Gene Dependency	1.0	2.45767
NCIH2172	DepMap CRISPR Gene Dependency	1.0	2.38481
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201852
PIANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46812
8232_SNRPF_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551502
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03138
496100576_HIP_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1992
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.978963
AA-52-JS03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06534
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.62992
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-38-BM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222645
SKBR3	DepMap CRISPR Gene Dependency	1.0	2.53574
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
MCF7_Epothilone A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015942
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.87655
PMC11618734-ac4c05127_si_004.xlsx-OPTI-PISA_automated_MTX_900ng-Unnamed_2_ZNF568	Rummagene Transcription Factor Associations 2026	1.0	null
Intraparietal sulcus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
COPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90482
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200498
K562_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173202
IC-05-WD74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225625
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298294
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLVL	DepMap CRISPR Gene Dependency	1.0	2.29984
RCM1	DepMap CRISPR Gene Dependency	1.0	2.51619
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Inferior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.575
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medial temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PX-12	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
Rto	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.258
QE-93-PG25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.528916
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH647	DepMap CRISPR Gene Dependency	1.0	2.68413
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.76145
A549_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167432
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.15851
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HSSCH2	DepMap CRISPR Gene Dependency	1.0	2.02629
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134796
MCF7_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187936
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.36886
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133077
MCF7_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161489
Crx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5047
Cranial ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.031
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A375SKINCJ2	DepMap CRISPR Gene Dependency	1.0	2.29385
DIAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29254
A549_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146181
Corpus striatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.52
GE-77-FY84_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276035
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
CB-02-XL81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.529124
IE-80-DC24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.482669
TAGLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74889
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.40416
DA-10-GX45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.985263
Regio parietalis capitis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-377-ZNF441_ZNF441	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10800016-table_s5_20230913_ddad186.xlsx-FvsC_-_DUX4_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
BE-38-UW72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.799025
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193147
K562_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188254
C1orf50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29155
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10147
NQO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33368
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.64206
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.51423
CC-68-YZ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298845
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187159
ZFYVE19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11797
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.65187
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.541
GSE149264,GSE149267_2_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SFN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16049
Cingulate gyrus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.477
SW1271_LUNG	CCLE Cell Line Proteomics	1.0	2.3428
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9546828-41389_2022_435_MOESM4_ESM.xlsx-Table_S3-Table_S3_Downregulated_genes_upon_ZNF148_knockdown_P_adj_0_05_Fold_change_1_5_ZNF148	Rummagene Transcription Factor Associations 2026	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1926
PGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09217
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215978
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.78063
TYKNU	DepMap CRISPR Gene Dependency	1.0	2.72486
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239148
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dermatophytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.801
GSE63857_3_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.917203
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334497
PECAPJ15	DepMap CRISPR Gene Dependency	1.0	2.18472
OCUG1	DepMap CRISPR Gene Dependency	1.0	2.30957
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08565
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1939
MCF7_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140562
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142430_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebral gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.971
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00856395
AC-36-SY22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.387357
GSE248874_1_v_0_pcdh9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8935
K562_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208141
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_SOX2_targets_Boyer_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139455_4_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OC-71-BZ81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37062
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.41995
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.87654
ITPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0789
K562_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018741
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.695149
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JIMT1	DepMap CRISPR Gene Dependency	1.0	2.49001
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145867
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268607
WM88	DepMap CRISPR Gene Dependency	1.0	2.15197
bacteroid-containing symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.322
MCF7_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015053
LAMTOR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32619
K562_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159788
GSE186620_0_v_1_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.812047
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AASS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3381
Defactinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.902669
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE160083,GSE160084_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Zaltoprofen	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109358
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.61499
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253021
ITCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78769
DB-56-XL71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269097
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151884
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.398003
GD-69-GP37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241742
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.445481
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.58048
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7836_SF3B2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04493
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.403
2339_DPCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.541192
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.624
Prespliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.276
NB-58-SA13_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306126
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.132
VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE	ChEA Transcription Factor Targets 2022	1.0	null
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.612988
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371952
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.193
CF-42-OS28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44344
BFTC905	DepMap CRISPR Gene Dependency	1.0	2.08227
Prefrontal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
Peribacteroid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.325
496100381_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.38677
Paraflagellar rod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.514
CWC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07237
A549_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205276
CB-46-FO63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.865138
CHL1DM	DepMap CRISPR Gene Dependency	1.0	2.49128
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.624
PMC11960529-mmc4.xlsx-Atrial_LHX2_KOoverCT-gene_LHX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166004_5_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-33-BM51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306532
Subthalamic nucleus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.298
GSE183271_2_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cutaneous mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.769
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31551
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285746
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.02294
LN340	DepMap CRISPR Gene Dependency	1.0	2.17214
A549_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149353
GSE243199_1_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157611
HHUA	DepMap CRISPR Gene Dependency	1.0	3.17146
JC-63-DO70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.24783
MCF7_Rigosertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120705
MCF7_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130609
MCF7_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162088
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.88817
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.77618
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05008
ND-07-WN37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203428
ME-11-OJ38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288451
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.0207
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.93656
MCF7_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.028627
GSE134986_2_v_8_oma1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9831
FBXO22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51577
MYLA	DepMap CRISPR Gene Dependency	1.0	2.07281
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hematopoietic cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.933
SHMAC4	DepMap CRISPR Gene Dependency	1.0	3.09334
AA-67-TF79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218578
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	2.23973
Medulla oblongata	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.522
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.665829
GLB1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11234
A549_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181091
GSE214823,GSE214824_6_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.805
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.7502
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.309
K562_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212496
MCF7_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163062
PROCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07408
Cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.649
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.973578
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03711
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.572965
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PC-80-LV29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27489
ECPAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7001
MCF7_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197366
S0-EE-YAXR_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249799
AZD1152-HQPA	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.15
UMUC3	DepMap CRISPR Gene Dependency	1.0	2.81957
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.386
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29125
VLDLR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29826
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203321
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.677413
PMC8384902-mmc2.xlsx-3_ASCL1_high_subtype-Gene_Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
CA-10-RU23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253781
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06379
GC-54-IZ89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200415
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3345
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0803
PMC4736761__F4	PFOCR Pathway Figure Associations 2024	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.48559
Spikelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.204
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
U2 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.913
YC-45-JD42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.775697
8102_SLC5A6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.517798
LA-44-KW22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.87303
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pons	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.312
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255267
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
MAP3K11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39143
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.802438
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	1.0	1.20734
Mitral valve insufficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.384
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.96281
ME-16-XW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223214
MM426	DepMap CRISPR Gene Dependency	1.0	2.29635
8126_SLU7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.649194
K562_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209426
NMB	DepMap CRISPR Gene Dependency	1.0	2.36936
PMC3348545-NIHMS263168-supplement-3.pdf-380-ZNF433_ZNF433	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173201_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-16-IR43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.710244
KB-49-NF63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439055
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.6536
PMC4067464-onc2013378x3.xls-Sheet1-Supplementary_Table_1_Top_1000_E2F4_Chip-Seq_targets_that_are_repressed_by_p53_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
CC-18-YW57_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.610238
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.36528
A549_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011779
A549_Iniparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158853
MCF7_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159628
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IE-80-DC24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203592
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337547
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
1017_TRIR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.20062
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1459
ATF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13332
HC-18-NB46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285599
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.655
CC-15-MK46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345491
Abductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
OC-21-IP52_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297595
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.963277
BA-88-HT15_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353728
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.607291
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5909_NVL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.524628
Multilymphoid progenitor cell_Umbilical cord blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
YB-18-SI56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227504
GSE189336_1_v_0_nitric oxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_5_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
SETD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22328
LE-80-BM08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.629268
9971_ZBTB14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05832
Olfactory lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.475
PMC10025425-mmc3.xlsx-ADNP_WH-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
H2BC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28662
GSE233183,GSE233187_3_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
XB-75-YN01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.572915
PRPF31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27323
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166728
A549_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139837
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400679
507_ARL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.515054
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5037
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609401
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211157
MCF7_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022385
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1108
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-51-LE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43629
BA-69-TQ80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.41704
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32488
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131318
GAMG_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	7.32316
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.4256
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21293
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PANC0403_PANCREAS	CCLE Cell Line Proteomics	1.0	3.75351
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3149
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187956
CF-42-OS28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.76283
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07173
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
rRNA metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.7
Cerebral peduncle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.777
BQ-788	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
CORO1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09968
K562_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144214
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fibre tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.777
K562_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019749
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.41496
A549_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108987
MCF7_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124308
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182965
PMC11495544-JPN-240026-at-2.pdf-165-NFIB_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MED10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49974
BT12	DepMap CRISPR Gene Dependency	1.0	3.05886
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Biceps brachii	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.047
A549_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180052
RFC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12544
K562_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179299
9505BIK	DepMap CRISPR Gene Dependency	1.0	2.1871
MCF7_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163603
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Regio orbitalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.614
BHLHE40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76938
Tinea pedis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.691
SYDE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08738
MCF7_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154536
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04648
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375316
PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1018
7427_RPF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.605976
Parahippocampal region	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.272
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498652
MCF7_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130112
PMC11109217-41420_2024_2017_MOESM3_ESM.xlsx-Fig_4H_TAF2-bound_genes-Tag_dentsity_of_TBP_ChIP-seq_signal_for_TAF2-bound_genes_in_Fig_4H_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2052_PLEURA	CCLE Cell Line Proteomics	1.0	3.74288
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.135
AKAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99705
DD-73-IP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233138
PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Inferior vena cava	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
MCF7_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156121
Helper T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.19
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.24599
MCF7_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142198
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
jm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
Dinoflagellate sulcus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.841
ATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02847
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.590738
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7705
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.45711
PMC12160862-ijbsv21p3573s2.xlsx-Table_S12-Supplementary_Table_S12_Differentially_Expressed_Genes_in_fibroblast_grouped_by_SOX11_expression_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184087_2_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.70245
CLUH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9172
GB1	DepMap CRISPR Gene Dependency	1.0	2.80095
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.555213
AF-80-GK24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342845
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RL952	DepMap CRISPR Gene Dependency	1.0	2.18543
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126657
GSE101546_2_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3'-5' exonuclease activity	GO Molecular Function Annotations 2023	1.0	null
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.5008
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.638485
GSE239541_11_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5512
PMC8283158-mmc2.xlsx-TCF4_NPC-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
1,4-DHNA	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.45
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.371224
VASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35229
RNA catabolic process	GO Biological Process Annotations 2025	1.0	null
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.467877
QA-34-PH05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.595949
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-46-GL76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238051
Medial cortex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.648
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.15
K562_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280177
K562_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152364