association dataset threshold value standardized value TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55F-1726-SM-2TF4R GTEx Tissue Sample Gene Expression Profiles 1.0 1.17599 liminal part of the r7 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18553 Lung squamous cell carcinoma_LUSC_TCGA-51-4080-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52877 POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null daunorubicin-4983 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128730_0_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058935 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60503 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36722 GSE111247_11_v_9_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 0.838907 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.840213 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56905 GTEX-XGQ4-0226-SM-4GIDS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84923 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.907403 WRNIP1 ENCODE Transcription Factor Targets 1.0 null m15 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.535 MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08584 BRD-K22139757 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32716 SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-520c-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41087 peripheral blood cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.581218 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16576 GTEX-TKQ1-1126-SM-4GIAZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.15618 BRD-K75206417 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62946 YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.51231 TBP ENCODE Transcription Factor Targets 1.0 null 3-Deazaneplanocin A DeepCoverMOA Drug Mechanisms of Action 1.0 0.78 hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.828865 r8 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16488 19096012-TableS5 GeneSigDB Published Gene Signatures 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal motor nucleus of the vagus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.92147 CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70639 SU-DHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6522 Brain Lower Grade Glioma_LGG_TCGA-CS-6666-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6369 BRD-K77354492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32571 BRD-M16762496_S1205_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE212848_1_v_0_pum1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.7203 Microcephaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.125 GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01298 H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEx BloodVessel 20-29 vs 40-49 GTEx Tissue-Specific Aging Signatures -1.0 -5.92799 lactobionic acid-1309 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SW 480 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933678 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null overexpressed GeneRIF Biological Term Annotations 1.0 null ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.875054 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.826362 Brain - Spinal cord (cervical c-1) GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.50454 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.68443 SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null GSE175787_13_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null PRDM1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K93875187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27288 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.65797 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3993 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_2_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null sirolimus-1221 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-231 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.35298 intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1258 GTEX-OXRP-0926-SM-48TC1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931012 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.06423 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null baclofen-1952 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MEG01 CCLE Cell Line Gene Expression Profiles 1.0 1.98771 MYC ChEA Transcription Factor Targets 1.0 null procarbazine-2971 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE151612_4_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tRNA methyltransferase activity GO Molecular Function Annotations 2025 1.0 null JJN-3 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GATA1 ENCODE Transcription Factor Targets 1.0 null horizontal nucleus of the diagonal band Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.11343 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null glycosyl compound biosynthetic process GO Biological Process Annotations 2025 1.0 null GSE202744_1_v_0_toyocamycin_human RummaGEO Drug Perturbation Signatures 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TT-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-X8HC-2826-SM-46MWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50269 BRD-K87537204 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.33092 r1 part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13294 HCC1428 CCLE Cell Line Gene Expression Profiles 1.0 1.673 GSE175787_4_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles 1.0 1.18092 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.986095 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Grey cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.691 BRD-K00676343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44087 H3K36me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K65891102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55452 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44854 GTEx BloodVessel 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures -1.0 -14.8447 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4768-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE206270_2_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cardiovascular Abnormalities CTD Gene-Disease Associations 1.0 1.14885 LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.829396 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K60759770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56885 Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18476 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02846 GTEX-XMK1-1026-SM-4B65H GTEx Tissue Sample Gene Expression Profiles 1.0 0.859957 H3K79me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78N-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null SNU81 CCLE Cell Line Gene Expression Profiles -1.0 -1.92703 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08022 CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19109 TAF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102505_1_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K07802542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1813 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24458 SMC3 ENCODE Transcription Factor Targets 1.0 null DU4475 CCLE Cell Line Gene CNV Profiles -1.0 -2.08604 KG-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.964575 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 LMSU CCLE Cell Line Gene CNV Profiles 1.0 1.72416 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.891972 GTEX-S7SF-1826-SM-3K2AD GTEx Tissue Sample Gene Expression Profiles 1.0 0.877552 KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.964575 ESR1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2196_KO_Tnfaip3_SRP103751 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NE-20-WM78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.552292 BRD-K21620541 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54493 hsa-miR-548a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 TTC709 DepMap CRISPR Gene Dependency 1.0 2.65371 episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15143 Fatty Liver, Alcoholic CTD Gene-Disease Associations 1.0 1.02821 MYC ENCODE Transcription Factor Targets 1.0 null SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06377 primary motor cortex (area M1, area 4)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.73497 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K17609687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12826 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XN-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Orbital area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63245 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.988874 Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Main olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07214 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.88591 Intermediate reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47151 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892989 mantle zone of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31253 JUND_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.073 BRD-K65969715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10303 GSE227698_2_v_1_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4775 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Perturb_12858_KO_Ift88_SRP125630 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.07758 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869609 GTEX-QDVN-0626-SM-2I3FP GTEx Tissue Sample Gene Expression Profiles 1.0 1.34614 primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.847907 DU-4475 GDSC Cell Line Gene Expression Profiles -1.0 -2.23314 thyroid_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.12525 doxorubicin-3291 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 1.08556 TC-71 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.5184 Lung squamous cell carcinoma_LUSC_TCGA-85-6798-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K63271817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16344 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24079 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.94378 H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4863-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE129370_0_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE165560_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K52152765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35908 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles 1.0 0.981575 superficial stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56052 GSE57875_1_v_0_hnrnpl_mouse RummaGEO Gene Perturbation Signatures 1.0 null H4K8ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.945898 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XMD1-0011-R3B-SM-4AT5R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38325 MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26103 EFM192A CCLE Cell Line Gene Expression Profiles 1.0 2.80687 BRD-K29542628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29231 lateral medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.18265 biological_process GO Biological Process Annotations 2015 1.0 null GSE165548_2_v_13_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null CTCFL_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HC-92-HE59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266523 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-33-EM56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.625736 TSC1_Deficiency_GDS4572_346_mouse_Naive CD4 T cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227698_5_v_3_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE148321,GSE169423_0_v_1_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-519b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE216988,GSE216989_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null NB69 DepMap CRISPR Gene Dependency 1.0 2.96685 Poisoning CTD Gene-Disease Associations 1.0 1.08126 BRD-K30973947 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04089 GSE227127_1_v_0_diclofenac_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K21467089 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07081 BRD-K37516186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40892 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.045 EB-67-WB79_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.25474 tolnaftate-1919 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE245134_0_v_1_atg5_mouse RummaGEO Gene Perturbation Signatures -1.0 null SKM-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 dorsal lateral geniculate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.36033 FOXM1-25889361-OE33-AND-U2OS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.99065 magnocellular diagonal band nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28296 Morris hepatoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.953 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCFL ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_10701_OE_MIR20B_SRP309809 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 SNUC4 CCLE Cell Line Gene Expression Profiles -1.0 -1.58225 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05331 BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.46257 naftidrofuryl-6687 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K21582416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.22203 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05742 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MC-40-IP75_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.275784 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.128 8-MG-BA GDSC Cell Line Gene Expression Profiles 1.0 1.44326 Ascites tumor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.694 Cardiovascular system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.717 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13096 BRD-K36393312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41363 GTEX-U4B1-0626-SM-3DB8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.00671 RAD21 ChEA Transcription Factor Targets 1.0 null GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15801 BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K63030320 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23628 BRD-K19011391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2331 SEM CCLE Cell Line Gene Expression Profiles -1.0 -1.72584 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.84634 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HOXC9 ChEA Transcription Factor Targets 1.0 null Febuxostat DeepCoverMOA Drug Mechanisms of Action 1.0 0.23 BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.275939 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXA2 ENCODE Transcription Factor Targets 1.0 null GSE129389_0_v_5_tropifexor_mouse RummaGEO Drug Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00516 BRD-K21000135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1324 Colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914656 HNF4A Pathway Commons Protein-Protein Interactions 1.0 null GSE231648_1_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null gigantocellular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.977614 EVSAT CCLE Cell Line Gene Expression Profiles -1.0 -1.68137 GSE253056_0_v_1_erythropoietin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE202434,GSE202438_3_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.983425 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_14227_KO_Lsd1_SRP064569 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.35884 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HG-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K87669982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24233 Alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GPR120_KO_GDS4830_414_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CNOT3 ChEA Transcription Factor Targets 1.0 null Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.992421 KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03847 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HUPT3 CCLE Cell Line Gene CNV Profiles 1.0 1.66319 JURLMK1 CCLE Cell Line Gene Expression Profiles 1.0 2.71813 STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226249_2_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00785 tauopathy GWASdb SNP-Disease Associations 1.0 0.600187 CD14+_Monocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.36655 RFX5 ENCODE Transcription Factor Targets 1.0 null H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U412-0526-SM-3DB9I GTEx Tissue Sample Gene Expression Profiles 1.0 0.883582 GSE212628_2_v_1_mier1_mouse RummaGEO Gene Perturbation Signatures 1.0 null intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 OB inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11963 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r4Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22063 GTEX-WI4N-0726-SM-3TW93 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836156 hsa-miR-375 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GTEX-XMD1-0826-SM-4AT52 GTEx Tissue Sample Gene Expression Profiles 1.0 0.90482 sulfacetamide-1859 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR4 CCLE Cell Line Gene CNV Profiles -1.0 -1.36273 EST1-17652178-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNB75 BioGPS Cell Line Gene Expression Profiles -1.0 -0.853123 BRD-K56799639 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14772 GSE74251_0_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null HEC6 CCLE Cell Line Gene Expression Profiles -1.0 -1.4755 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXA1-25552417-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11302 BRD-K74116035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91847 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null pancreas HPA Tissue Gene Expression Profiles -1.0 -1.20727 SNU626 CCLE Cell Line Gene CNV Profiles -1.0 -1.64 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tRNA-intron endonuclease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.438 primary auditory cortex (core)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.51272 GTEX-QESD-0626-SM-2I5G4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.858173 CL14 CCLE Cell Line Gene CNV Profiles -1.0 -1.65286 GSE169152_3_v_1_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21773 MYC-19915707-AK7-human ChEA Transcription Factor Binding Site Profiles 1.0 null superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61862 SAP30 ENCODE Transcription Factor Targets 1.0 null NRF1 ENCODE Transcription Factor Targets 1.0 null homologue GeneRIF Biological Term Annotations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-VUSG-0426-SM-3GIKD GTEx Tissue Sample Gene Expression Profiles 1.0 1.04997 BRD-K18076490 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00741 camptothecin-3887 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1 ENCODE Transcription Factor Targets 1.0 null HUP-T3 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 MDAMB231 CCLE Cell Line Gene CNV Profiles -1.0 -3.15 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.316 GTEX-Q2AG-1126-SM-48U1P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12481 GTEX-R53T-0526-SM-3GADL GTEx Tissue Sample Gene Expression Profiles 1.0 2.73847 BRD-K19245310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65958 GSE221327_10_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.933389 tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.099449 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56565 SUIT2 DepMap CRISPR Gene Dependency 1.0 2.23425 GSE175787_5_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 2.82699 breast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.239913 GTEX-QMR6-0011-R4A-SM-32PKU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989578 H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSTB_KO_GDS5090_398_mouse_cerebella GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null dorsalstriatum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.06025 GTEX-PVOW-1626-SM-48TC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15422 superficial stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30063 MZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.830536 acetylsalicylic acid-1145 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60015 HCC1419 GDSC Cell Line Gene Expression Profiles 1.0 2.62021 CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF7 ENCODE Transcription Factor Targets 1.0 null RUNX1_KO_GDS1511_250_mouse_Embryos at E8.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.976033 GSE216273,GSE216292_14_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6841 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.90452 fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.21913 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A27407220 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59312 HT29 CCLE Cell Line Gene CNV Profiles 1.0 1.5085 ERG-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.676495 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K51525251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37875 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.42743 FLI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE116492,GSE116495_3_v_2_stag2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.647252 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2895 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null transferase activity GO Molecular Function Annotations 2015 1.0 null membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 BRD-K47776393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28998 H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null helveticoside-3770 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lateral amygdaloid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09778 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHT101 DepMap CRISPR Gene Dependency 1.0 7.01031 layer 1 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11781 9592_UNC45A_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.56875 inferior temporal gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07937 CTCF_WI38_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221577_2_v_0_pik3r1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T5JC-0008-SM-4DM6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.64004 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7477-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -2.00974 BRD-K19699893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60679 CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lanatoside C-3771 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Infertility, Male CTD Gene-Disease Associations 1.0 1.47064 GSE167224,GSE168147_3_v_5_hnrnpk_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K73524144 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35806 GTEX-RWS6-0001-SM-3NMAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.01328 Inferior colliculus, dorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1905 OCI-LY-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40727 SETDB1 ENCODE Transcription Factor Targets 1.0 null GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42826 GSE241701_4_v_3_daxx_mouse RummaGEO Gene Perturbation Signatures 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.441356 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.922558 outer CP in (rostral) midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51852 Acute Myeloid Leukemia_LAML_TCGA-AB-2877-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K87554792 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01003 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.633252 H3K79me2_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD105+_Endothelial BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.07629 GTEX-R55G-0326-SM-48FDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08946 GSE157904_2_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37091 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP-320650-01-4557 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.134583 BHT101 CCLE Cell Line Gene CNV Profiles 1.0 2.2593 GSE148066,GSE157787_11_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K03884263 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00891 NCI-H211 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 19204204-SupplementaryTable1 GeneSigDB Published Gene Signatures 1.0 null BRD-K97086564 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34554 r7 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28203 HDAC1 ENCODE Transcription Factor Targets 1.0 null GSE221327_10_v_9_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null GSE185944_0_v_3_pth1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE171352_2_v_3_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null HT144SKINFV2 DepMap CRISPR Gene Dependency 1.0 4.64298 inner CP in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.847254 hsa-miR-450b-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 MXI1 ENCODE Transcription Factor Targets 1.0 null CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ventral tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0598 LY-294002-5596 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XBEW-0126-SM-4AT66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.948082 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.825774 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null staurosporine-312 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K49529874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08776 aminoacyl-tRNA synthetase multienzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.86 SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE165122_0_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL148 CCLE Cell Line Gene CNV Profiles -1.0 -2.25065 intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K86593041 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67003 CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.875936 HT29 CCLE Cell Line Gene Expression Profiles -1.0 -2.53359 PRKACA_knockout_266_GSE20984 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.17052 GTEX-XOTO-0011-R5A-SM-4B657 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10218 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061079 AOB, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24068 primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.36818 Brain Lower Grade Glioma_LGG_TCGA-QH-A6CW-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36361 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.67737 H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.979932 GTEX-X585-3026-SM-46MWF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880256 LP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13927 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 2-BFI LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31068 GSE122215,GSE122217_0_v_1_peg10_mouse RummaGEO Gene Perturbation Signatures 1.0 null TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-71-CI37_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.412843 Acute Myeloid Leukemia_LAML_TCGA-AB-2918-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.2765 SKUT1 CCLE Cell Line Gene Expression Profiles -1.0 -2.13431 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null delavirdine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01776 GTEX-S7SE-0726-SM-2XCD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1029 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.63484 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Daltons lymphoma ascites TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.891 GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56043 GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32973 OB-06-WW76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377184 TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.18887 KURAMOCHI GDSC Cell Line Gene Expression Profiles 1.0 2.12174 CF-61-EH59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249284 MEF2D_KD_GDS4759_339_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K23024526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38672 BRD-K38737333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.36474 layer 2 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15328 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE234514,GSE234516_1_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 1.59232 4935_MED14_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.516227 BRD-K21937603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49951 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1367 ventral tegmental area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.930221 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EGR1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.21622 OVISE CCLE Cell Line Gene Expression Profiles -1.0 -2.10086 TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3 ENCODE Transcription Factor Targets 1.0 null NC-27-AD53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.430046 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KNS81 DepMap CRISPR Gene Dependency 1.0 4.80773 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE207301,GSE207303_1_v_2_tp53bp2_human RummaGEO Gene Perturbation Signatures 1.0 null torasemide-2956 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3285 GSE137144_3_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.830712 breast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.093937 BRD-K79631534 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17179 HEC151 CCLE Cell Line Gene Expression Profiles -1.0 -1.69028 BRD-K76558091 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32058 GSE183271_1_v_0_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -4.16971 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.24247 TC71 CCLE Cell Line Gene CNV Profiles 1.0 1.92745 GTEX-QMRM-0726-SM-2I5G8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12051 BRD-K21009787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1893 GSE134375_0_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K75997540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70311 SRF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.47032 GTEX-OOBJ-2626-SM-2I3F6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.80487 posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.70784 POLR2AphosphoS5_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.89704 Lobules IV-V, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.9424 GATA2-19941826-K562-human ChEA Transcription Factor Binding Site Profiles 1.0 null chlorprothixene-1272 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.70494 H3K36me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 2.00175 Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6847-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null digoxigenin-4680 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K56ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GC-69-JF03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.380953 GTEX-POYW-1326-SM-48TCG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78963 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEPG2 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -2.72015 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.24385 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18052 5927_OGDH_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.663174 klf4_17017123_rko_gof_human_gpl96_gds1942 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.162906 NCI-H1781 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881694 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.936053 BRD-K58333451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89585 GSE224556,GSE224557_6_v_1_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05592 NCOR-22424771-293T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.002 Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15204 trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064739 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-N7MS-2326-SM-2HMLD GTEx Tissue Sample Gene Expression Profiles 1.0 1.12828 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04353 GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959106 JIMT-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.35245 SMC3-22415368-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ketoconazole-1285 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K15602285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46874 JURLMK1 CCLE Cell Line Gene CNV Profiles 1.0 2.45562 GC-07-UO80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.298378 ncrna processing GO Biological Process Annotations 2015 1.0 null GSE146982_4_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50673 HCC2185 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.731592 BRD-K90475322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15037 cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.44759 GTEx Stomach 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures -1.0 -3.86182 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.79983 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43018 CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24096 CEBPB-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE175787_8_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K66526269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13126 anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4476 TE8 CCLE Cell Line Gene CNV Profiles 1.0 2.18322 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE127790_6_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.45402 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2 ENCODE Transcription Factor Targets 1.0 null HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36805 GSE175787_13_v_2_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02408 Penis_Foreskin_Fibroblast_Primary_Cells_skin02 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.84296 TC-71 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 BRD-K37619154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09764 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CHRND LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00572546 Medial amygdalar nucleus, anteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14138 GTEX-OIZI-0726-SM-2XCEI GTEx Tissue Sample Gene Expression Profiles 1.0 0.974989 BRD-K23435841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11572 GSE166004_3_v_2_pld1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 2.42266 Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78195 wybutosine metabolic process GO Biological Process Annotations 2025 1.0 null NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930726 protein binding GO Molecular Function Annotations 2015 1.0 null ventrolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.48066 GTEX-UTHO-1826-SM-3GAFE GTEx Tissue Sample Gene Expression Profiles 1.0 0.861541 BRD-K10196668 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04422 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 2.13709 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tRNA modification GO Biological Process Annotations 2025 1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8606_KO_Mir132/212_SRP064164 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.90507 orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.71948 GSE127790_4_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.896 RAD21-21589869-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07416 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MET_knockout_247_GDS3148 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.83546 BRD-K26051127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30318 cerebralcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.928239 SAOS-2 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GTEX-OHPN-0011-R1A-SM-2I5GB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00557 liver HPA Tissue Gene Expression Profiles -1.0 -0.922902 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05973 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles 1.0 0.883915 non-syndromic X-linked intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.159 AU565 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.905935 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17308 dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.54144 E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKBR3 DepMap CRISPR Gene Dependency 1.0 2.5401 GSE253795_1_v_0_alkbh5_human RummaGEO Gene Perturbation Signatures 1.0 null KDM5A ENCODE Transcription Factor Targets 1.0 null SOX2-20726797-SW620-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K07576726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89844 0175029-0000-4713 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Muscle - Skeletal GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.34501 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24458 ELK1-19687146-Hela cells-human ChEA Transcription Factor Binding Site Profiles 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null JURL-MK1 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 BRD-K36002293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51344 GSE151612_4_v_3_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K17199106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25378 imipramine-1849 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K30121969 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22861 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-0326-SM-48FD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64855 BRD-K17315445 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02904 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47X-01A-31R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K96970199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72595 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6906-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE245270_1_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null GSE157383_0_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-596 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 AE-64-IK64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236105 Lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08683 Prostate adenocarcinoma_PRAD_TCGA-CH-5754-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null COLO792 CCLE Cell Line Gene Expression Profiles -1.0 -1.9199 GTEX-WI4N-2726-SM-3LK7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00709 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.63381 GTEX-SIU7-1126-SM-2XCDW GTEx Tissue Sample Gene Expression Profiles 1.0 0.859093 Desvenlafaxine DeepCoverMOA Drug Mechanisms of Action 1.0 0.25 Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K30589514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.97727 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21-21589869-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22553 16617318-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles 1.0 0.956391 superior temporal gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.37687 Anterior olfactory nucleus, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.69976 GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18521 BRD-K60713831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11245 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31904 mantle zone of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70453 CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K27529556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83328 Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14512 BRD-K64704925 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35951 hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.843741 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11719 primary motor cortex (area M1, area 4)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1789 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K65107903 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20416 OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257807 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null QB-69-QH67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273801 shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59439 superficial stratum of r7Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13467 HT-29 GDSC Cell Line Gene Expression Profiles -1.0 -2.5511 18497862-TableS3 GeneSigDB Published Gene Signatures 1.0 null GSE148657_2_v_0_cd44_human RummaGEO Gene Perturbation Signatures -1.0 null primary auditory cortex (core)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.85438 CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null thiamine-1744 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary metabolic process GO Biological Process Annotations 2015 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE58724_1_v_0_oxymetholone_mouse RummaGEO Drug Perturbation Signatures -1.0 null H4K91ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CL34 CCLE Cell Line Gene Expression Profiles -1.0 -2.56218 HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.57762 Nuclear RNA export factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.916 CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3 ENCODE Transcription Factor Targets 1.0 null SNU1544 DepMap CRISPR Gene Dependency 1.0 2.29591 septohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25423 BCLAF1 ENCODE Transcription Factor Targets 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null YY1_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null polymorph layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19236 NCI-H1650 COSMIC Cell Line Gene Mutation Profiles 1.0 null r5 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01706 KM12 CCLE Cell Line Gene Expression Profiles -1.0 -2.37967 CD-47-YL43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.323196 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE48812_7_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null 0175029-0000-3691 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.851192 GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.37143 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Amastigote TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.713 STK410283 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.55 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7061-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K40282027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13815 CEBPB-24764292-MC3T3-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KURAMOCHI COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7M4-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K88016677 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32092 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-AB2X-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.44389 CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Endonuclease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.5 sulfaphenazole-1836 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Congenital nervous system abnormality DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.061 oxamniquine-2924 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148066,GSE157787_9_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null 20559987-TableS1 GeneSigDB Published Gene Signatures 1.0 null GTEX-T6MN-0726-SM-32PML GTEx Tissue Sample Gene Expression Profiles 1.0 0.958625 superficial stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52795 breast GeneRIF Biological Term Annotations 1.0 null organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null layer 3 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25598 BF-94-CQ58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.546815 GSE210682_0_v_3_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-0526-SM-2TF4N GTEx Tissue Sample Gene Expression Profiles 1.0 0.831608 frontal pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27193 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EKC/KEOPS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.549 GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65179 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.99195 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CSTB_KO_GSE47516_678_mouse_mouse cerebellum at P30 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-73-QS80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.224194 BRD-K34942615 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05686 OVCAR-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RVPU-0011-R10A-SM-2XCAH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861419 fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.80264 TAL1 ENCODE Transcription Factor Targets 1.0 null GSE229973_4_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null 1844_CPSF6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.500636 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF JASPAR Predicted Transcription Factor Targets 1.0 null orbital frontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.7263 BD-69-GX17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.267451 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas GTEx Tissue Gene Expression Profiles -1.0 -1.16428 GTEX-X261-0011-R7A-SM-4E3JJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25409 GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 0.910224 Prostate adenocarcinoma_PRAD_TCGA-CH-5767-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bone marrow HPA Tissue Gene Expression Profiles -1.0 -1.65873 intermediate stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15192 GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903538 catalytic activity, acting on a tRNA GO Molecular Function Annotations 2025 1.0 null BRD-K09521953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09723 GSE128333_2_v_0_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE213588_10_v_4_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE169590_6_v_1_rptor_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10849 primary auditory cortex (core)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20515 PATU8902 DepMap CRISPR Gene Dependency 1.0 3.28162 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null paclitaxel_homo sapiens_gpl570_gse39042 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE195663_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.59737 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles 1.0 1.10855 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A4ZW-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K15269548 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00386 BV-173 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04141 BRD-K74114857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14786 6219_PES1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.630686 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSTB_KO_GDS5090_200_mouse_Cerebellar granule cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K56531121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92557 23132/87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45032 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.872188 BJAB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.92364 DU4475 CCLE Cell Line Gene Expression Profiles -1.0 -1.84175 ES6 GDSC Cell Line Gene Expression Profiles -1.0 -1.9859 GSE173282_1_v_0_marchf6_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Tou TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.132 Lung adenocarcinoma_LUAD_TCGA-95-7948-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Vacuolar transporter chaperone complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.055 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K12867546 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05456 Internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 intermediate stratum of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16833 edrophonium chloride-2019 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XXEK-1326-SM-4BRV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28672 FA-65-UA27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228901 nucleus incertus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53921 GTEX-N7MT-0011-R2a-SM-2I3GI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834007 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r8 part of linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.86256 GSE153867_6_v_8_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null RA-49-ZB08_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262695 stratum pyramidale of caudal CA3 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09952 GSE155836,GSE155839_3_v_2_alvocidib_human RummaGEO Drug Perturbation Signatures -1.0 null fulvestrant-1238 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE202434,GSE202438_4_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPB ChEA Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.873694 GTEX-WH7G-1726-SM-4LVKY GTEx Tissue Sample Gene Expression Profiles 1.0 0.96294 MYC-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.026375 EFM192A CCLE Cell Line Gene CNV Profiles 1.0 2.25655 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8312-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OlfactoryBulb BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.56346 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE152246_0_v_1_dihydrotestosterone_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EVSA-T GDSC Cell Line Gene Expression Profiles -1.0 -2.12231 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.847815 BRD-K79555018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07683 THAP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158632_2_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null Nucleus ambiguus, ventral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55703 GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14627 perifornical nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.963222 GTEX-UJMC-0326-SM-3GAE2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.940763 ELK4_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OB granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08819 posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1105 BRD-A84045418_Calpeptin_MDST8_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null wybutosine metabolic process GO Biological Process Annotations 2023 1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.638956 GSE193588_1_v_0_pax3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RWSA-0226-SM-2XCBA GTEx Tissue Sample Gene Expression Profiles 1.0 0.890057 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06501 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.40666 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17968 H3K36me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K24877937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96376 tRNA methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.569 H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PX3G-1026-SM-48TZW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12365 BRD-K63665694 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36022 GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31173 SKBR3 CCLE Cell Line Gene Expression Profiles 1.0 1.85643 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057594 GTF2F1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2901-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE220520_5_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null NC-01-ET52_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207771 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU1J-1926-SM-2TF6S GTEx Tissue Sample Gene Expression Profiles 1.0 0.914497 BRD-K01980291 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05713 GSE231720,GSE231724_2_v_0_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.15915 GSE183271_5_v_0_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null 0316684-0000-7098 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 7671_SBNO2_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.528421 Kidney BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.918931 CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Medullary reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03618 intermediate stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.10212 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.223 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K01095342 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.3798 BE-27-RQ61_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.37794 BRD-K93268593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17723 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.910127 thorax TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.084159 Sporulating cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.85 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17332 GSE169152_3_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE100316_5_v_4_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-NPJ8-0011-R4a-SM-2HML3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858874 HMV-II cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.039 SOX17 ChEA Transcription Factor Targets 1.0 null CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02358 Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44746 EE-85-SK26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.255535 NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.865031 GSE96777,GSE96778_3_v_2_zbtb4_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N6-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r8 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0978 SW1271 CCLE Cell Line Gene CNV Profiles -1.0 -1.35837 CTCF_GM12865_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07147 ntera2 HPA Cell Line Gene Expression Profiles -1.0 -1.68688 Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.852272 H3K4ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 7504_RPS15_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.549582 Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.11251 GTEX-WHSE-0011-R1A-SM-3P5ZK GTEx Tissue Sample Gene Expression Profiles 1.0 0.843279 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5461-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null endometrium_8b HPA Tissue Sample Gene Expression Profiles 1.0 0.84281 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal prosubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836351 ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17381 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.11538 myclobutanil LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08567 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.87259 BRD-K37831546 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06585 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35455 GTEX-PX3G-2626-SM-2I3EG GTEx Tissue Sample Gene Expression Profiles 1.0 1.44454 GSE137144_4_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JF-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.36943 CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845609 GSE161055,GSE161056_1_v_0_hira_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC-20876797-MEDULLOBLASTOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null YY1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-0726-SM-3P619 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912937 r7 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38676 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30876 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-2780 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.747 Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null duodenum HPA Tissue Protein Expression Profiles 1.0 2.61979 Lung squamous cell carcinoma_LUSC_TCGA-77-7337-01A-21R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AG-0011-R11A-SM-2HMKZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.54263 RMG-I GDSC Cell Line Gene Expression Profiles -1.0 -1.49889 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SARS-CoV MA15_Day4_None_GSE49262 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.97396 CCND1 ChEA Transcription Factor Targets 1.0 null H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BHT-101 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 SUDHL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.6516 MZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08287 CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.94509 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.28656 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.31226 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38793 BRD-K71496240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55645 CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42598 GTEX-QV31-0726-SM-3GAEG GTEx Tissue Sample Gene Expression Profiles 1.0 1.59308 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE90710_1_v_0_med13_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.93172 HDAC2 ENCODE Transcription Factor Targets 1.0 null CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null principal sensory nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.31019 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S3XE-0526-SM-4AD4G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828478 diphenylpyraline-2205 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-NL3H-0011-R10A-SM-2I3E9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.904396 STAT3 ENCODE Transcription Factor Targets 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9927 TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R53T-1326-SM-48FCQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.2497 GTEX-OXRN-0011-R5A-SM-2I5EF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02714 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32432 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5893-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10759 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SA-32-CC58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244176 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.11605 GSE198826,GSE198911_1_v_2_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MA-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4488-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IB-78-AY41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.361716 BRD-K60719499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04199 Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.319 NFYA JASPAR Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-6207-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26238 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2416 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.03084 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IR-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14822 BRD-K59191599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11809 organic substance metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5470-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.10979 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NR-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K65626032 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18844 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE173578_1_v_0_atf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CA-73-BW50_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.397124 GSE186483_6_v_4_lrrk2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.750173 BRD-K30117087 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36762 ER-23166858-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34556 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K69132276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48555 COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.81503 KMM1 DepMap CRISPR Gene Dependency 1.0 2.56065 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07503 BRD-K43449580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75763 Choline CTD Gene-Chemical Interactions 1.0 null GSE239844_1_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2785_EXOC8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.523846 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17308 DD-74-PJ26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364515 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.850172 OB-06-WW76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.21075 CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.88307 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.877287 OB-06-WW76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.348639 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.824761 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K44807762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31301 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.12519 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCHACV CCLE Cell Line Gene Expression Profiles -1.0 -1.53783 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870432 tRNA (m2G10) methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.208 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7449_RPL23A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.527201 0179445-0000-3630 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HDAC2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15143 OCUG1 DepMap CRISPR Gene Dependency 1.0 3.77082 GTEX-OOBK-2626-SM-2HMKY GTEx Tissue Sample Gene Expression Profiles 1.0 0.970403 GSE210682_2_v_1_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null intermediate stratum of r5Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01876 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MQ-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K62000282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1797 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-7711-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Box C/D RNP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.577 HEC-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.89548 CNOT3-19339689-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HC-63-SV27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250493 GTEX-SE5C-0726-SM-4BRWY GTEx Tissue Sample Gene Expression Profiles 1.0 1.11167 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KP4 CCLE Cell Line Gene Expression Profiles 1.0 1.36784 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BL-70 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57818 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.51042 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A6-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE198036,GSE198041_4_v_3_sox9_mouse RummaGEO Gene Perturbation Signatures -1.0 null tumors GeneRIF Biological Term Annotations 1.0 null PL18 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 TE-26-XS06_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328249 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE143643,GSE143644_4_v_5_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null OE-78-XD40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214551 dehydrocholic acid-2023 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ChIP_CNOT3_19339689 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.19796 Ribonuclease MRP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.945 Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66925 RBBP5 ENCODE Transcription Factor Targets 1.0 null stomach HPA Tissue Protein Expression Profiles 1.0 1.37806 EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-L3-A524-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02523 GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70233 BRD-K90999585 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91149 ovary TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Mitochondrial large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.558 subthalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01499 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.86191 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.30498 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.35913 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K03352270 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06978 CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148066,GSE157787_2_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE213588_10_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.920565 CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K47092271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03467 amygdaloid complex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.58201 GTEX-S32W-1126-SM-4AD5V GTEx Tissue Sample Gene Expression Profiles 1.0 0.876811 plexiform layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62685 butein-582 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.46718 inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.848929 USF1 ENCODE Transcription Factor Targets 1.0 null BRD-K50004365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80678 ISM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00551421 BRD-K26335565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25595 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null SRF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K74968522 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54123 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08106 LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00124 H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X261-0226-SM-3NMD2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00218 YC-45-JD42_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201628 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205540_2_v_0_phloridzin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Carcinogenesis DisGeNET Gene-Phenotype Associations 1.0 null FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.235037 GTEX-QVUS-0008-SM-447AY GTEx Tissue Sample Gene Expression Profiles 1.0 1.33155 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 1.39013 SK-MEL-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.953064 HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r1BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1653 GSE148321,GSE169423_2_v_1_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null alexidine-4721 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06147 Perturb_66_OE_Zscan4_SRP252595 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.87188 CPC-N COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35119180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1994 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7604-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFG7-1826-SM-3GIL1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.906363 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210870_0_v_1_snai1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2363 GSE220520_5_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03324 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-20876797-MEDULLOBLASTOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null r9 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25099 GSE231648_4_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL2-22936984-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.934393 A-CA-04-2009(H1N1)_3Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.20205 GTEX-Q2AH-0726-SM-2I3EA GTEx Tissue Sample Gene Expression Profiles 1.0 0.874147 shell of SCH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70435 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPK-2626-SM-2HMK9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.938063 SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-3789-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00736 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 1.63158 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.30307 Intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K36me3_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153867_6_v_3_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null BF-94-NX85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239945 camptothecin-2321 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 20077526-TableS3 GeneSigDB Published Gene Signatures 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43689 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3233 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3657 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.221 GTEX-XMK1-0326-SM-4B652 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879126 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5465-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1-21170310-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45483 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19941 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.99216 morphological abnormality of the central nervous system GWASdb SNP-Phenotype Associations 1.0 0.075424 MF-11-EW49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.359895 YY1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933678 Declive (VI), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90254 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA ENCODE Transcription Factor Targets 1.0 null BRD-K01281780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24412 CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH211 CCLE Cell Line Gene Expression Profiles 1.0 1.89486 GSE199255,GSE199356_4_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K43390655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.5759 r9 part of the basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33663 SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210476_11_v_4_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H1-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE48812_9_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null cSARS Bat SRBD_60Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.68712 Trophoblast stem cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.735 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K23064726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32171 TSSK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00596943 BRD-K00974016 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22462 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.846287 CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186483_1_v_4_lrrk2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T5JW-0226-SM-4DM7I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833933 tranylcypromine-1417 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QXCU-0326-SM-2TC63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08341 CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mantle zone of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4706 GSE143462_0_v_1_omipalisib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles 1.0 0.949921 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-11A-02R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE115395_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null AD-89-XG11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241406 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.474099 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0655 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.863289 Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-PT-A8TR-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MFM223 DepMap CRISPR Gene Dependency 1.0 4.13541 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.51082 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41857 GTEX-W5X1-0426-SM-3GILB GTEx Tissue Sample Gene Expression Profiles 1.0 1.29165 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58757 hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.96169 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tRNA processing Reactome Pathways 2024 1.0 null POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K74445272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23421 AA-58-FJ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.363675 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28946 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.10945 GSE213588_10_v_12_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null SRF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.717 CH157MN DepMap CRISPR Gene Dependency 1.0 4.7553 POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11003 GTEX-OHPL-1026-SM-3MJGI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988973 amygdaloid complex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.967948 H3K79me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.28951 Lobules IV-V, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78611 paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.87893 BRD-K96807219 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35214 r7 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15192 ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S33H-0626-SM-2XCBJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.957431 thyroid_5d HPA Tissue Sample Gene Expression Profiles 1.0 0.959637 dorsal endopiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37005 U-118-MG COSMIC Cell Line Gene Mutation Profiles 1.0 null camptothecin-4541 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BHT101 CCLE Cell Line Gene Expression Profiles 1.0 1.97127 NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.002 breast cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.250627 STAT1 ENCODE Transcription Factor Targets 1.0 null GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 1.62716 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSG-1726-SM-4KKZL GTEx Tissue Sample Gene Expression Profiles 1.0 1.07068 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.691287 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11067 BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.306353 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864937 Lung adenocarcinoma_LUAD_TCGA-75-7031-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E1-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K14392619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35198 BRD-K99116119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0165 GSE216274,GSE216292_4_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44473 FOXA1-27197147-CHIP-SEQ-ENDOMETRIOID-ADENOCARCINOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null AF-99-HA02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.308172 Perturb_6251_KO_Dicer_SRP041835 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 BRD-K39081386 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20116 6446_PLEKHJ1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.522015 LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.868335 Medullary reticular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37273 YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221327_10_v_2_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null tyrphostin AG-825-1114 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HDAC6 ENCODE Transcription Factor Targets 1.0 null GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48067 GTEX-VUSG-1226-SM-4KKZF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862779 amodiaquine-1570 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.3566 GTEX-XOTO-0011-R9A-SM-4GICI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1395 BRD-K67525206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79959 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28203 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mantle zone of r4Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2982 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null mRNA editing complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.191 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dextromethorphan-1281 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K07602825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28853 epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057085 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210373_0_v_1_cntnap4_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K55946794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21027 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-0008-SM-4KL25 GTEx Tissue Sample Gene Expression Profiles 1.0 1.62102 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.01993 ELK4 ENCODE Transcription Factor Targets 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.00127 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.50622 TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE165689_0_v_1_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null Riley-Day syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.105 KB-77-BA46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.441 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-UT-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.51634 intermediate stratum of r6Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27935 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.374 H3K4me3_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MB-32-LQ97_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.264466 H2BK15ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90562 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO678 CCLE Cell Line Gene Expression Profiles -1.0 -1.48404 BRD-K28414977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36296 ZFP42 ChEA Transcription Factor Targets 1.0 null POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-1726-SM-2YUNB GTEx Tissue Sample Gene Expression Profiles 1.0 0.866289 RELA_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE208350_0_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K28700379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1278 GTEX-PSDG-0726-SM-2I5FN GTEx Tissue Sample Gene Expression Profiles 1.0 1.14039 BRD-K10638173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72846 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE137144_5_v_7_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.992215 GTEX-RWS6-1126-SM-47JXC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931646 SW48 CCLE Cell Line Gene Expression Profiles -1.0 -3.63337 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZU-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Promastigote TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.722 CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21532 HCC1954 CCLE Cell Line Gene CNV Profiles 1.0 1.40381 CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.868189 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75799 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03216 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26868 r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05682 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64245 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25514 H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEC-1-A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05833 FLI1_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0626-SM-2HMJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29365 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIN87 CCLE Cell Line Gene Expression Profiles 1.0 1.37401 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933678 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70K-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE239844_1_v_12_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE189356_5_v_6_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AD-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-150 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE224742_0_v_1_slc1a5_human RummaGEO Gene Perturbation Signatures -1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BA-84-WN26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.563184 CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61807670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22436 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K28813194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60967 cellular aromatic compound metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K03875473 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07307 GTEX-UPK5-1426-SM-4JBHH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0425 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.366 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054961 inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.31447 AE-67-FF84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.24068 GTEX-UPIC-0226-SM-3GADO GTEx Tissue Sample Gene Expression Profiles 1.0 0.873065 Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48393 tiratricol-2096 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lobule III, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21409 BRD-K43336921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04929 USF2 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AR-19668381-PC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.940264 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29602 BRD-K02920459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91258 YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null r3 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56234 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.878833 BRD-K44521151 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36729 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AD-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-5783-01A-41R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.38591 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Hypomyelinating leukodystrophy 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.68 nervous system disease GWASdb SNP-Disease Associations 1.0 0.049069 BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.74909 periventricular stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31188 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K71919612 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.03104 IM-95 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33889 CEBPB-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905201 GTEX-QEG5-1126-SM-33HC2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.90227 cochlear nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06821 GTEX-WFG8-2226-SM-3GIL9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865352 blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052474 AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.13231 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE138938_1_v_4_foxp2_human RummaGEO Gene Perturbation Signatures -1.0 null raphe nuclei of medulla Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04478 GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986109 Piriform area, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32688 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.36573 HCC1187 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.71742 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PSDG-1526-SM-48TCY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.937511 Rectum adenocarcinoma_READ_TCGA-F5-6864-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K73573090 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00351 DND41 CCLE Cell Line Gene Expression Profiles -1.0 -1.98359 GTEX-QEL4-0726-SM-3GIJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04991 SRF-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050728 Diphthamide deficiency syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.476 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDAMB361 DepMap CRISPR Gene Dependency 1.0 2.65024 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01893 cerebellum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.923117 SJCRH30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852528 GSE186483_2_v_0_lrrk2_mouse RummaGEO Gene Perturbation Signatures 1.0 null AB-17-WP43_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.24177 NCIH211 CCLE Cell Line Gene CNV Profiles 1.0 1.60724 EVSAT CCLE Cell Line Gene CNV Profiles 1.0 1.59418 IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.247007 HS695T DepMap CRISPR Gene Dependency 1.0 5.60892 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVMANA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.956328 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K31393518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4135 skin TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE148066,GSE157787_8_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null spinal trigeminal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14894 GSE165122_2_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054784 GTEX-R55F-0011-R8A-SM-2TF4F GTEx Tissue Sample Gene Expression Profiles 1.0 1.0111 GSE169152_3_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null methapyrilene-1588 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43368 GSE227698_2_v_4_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SA-A6C2-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Organellar large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.553 ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.824501 AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.00359 SK-N-DZ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.98614 ZFP42-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE160083,GSE160084_1_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.098 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.96012 GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06263 dorsal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35575 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59393 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2 ChEA Transcription Factor Targets 1.0 null SNU61 DepMap CRISPR Gene Dependency 1.0 5.44875 GSE111247_2_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ASH2L-23239880-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05274 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.05913 ncrna metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K76147162 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34211 H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HOXB4 ChEA Transcription Factor Targets 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8437-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OE19 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7742-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K39179354 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10654 GSE133213_9_v_15_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.91512 GSE202434,GSE202438_15_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.234804 GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03704 posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.45092 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null iPS-18 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.83641 GTEX-T6MN-0011-R9A-SM-32QOZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01498 Prostate adenocarcinoma_PRAD_TCGA-2A-A8W1-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BL5634 (AKAP12) NURSA Protein Complexes 1.0 null BRD-K38977317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80982 inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0493 SNU119 CCLE Cell Line Gene CNV Profiles 1.0 1.69251 MHH-PREB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K18313650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05137 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K72681425 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01846 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43484 GSE119345_2_v_3_bexarotene_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8-M-PDOT LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08802 BRD-K89837874 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.97456 RAD21_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Peripheral artery disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.717 BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207514,GSE207515_0_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QQ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5525-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LB2241-RCC GDSC Cell Line Gene Expression Profiles -1.0 -1.61544 CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.984826 KYSE-50 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 2.44102 7754_SEC62_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 2.18158 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.09368 superficial stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25099 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Penis_Foreskin_Melanocyte_Primary_Cells_skin03 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.96442 periventricular stratum of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19522 NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.02516 BA-77-US35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.341984 CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMSCTR DepMap CRISPR Gene Dependency 1.0 3.07 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839409 GTEX-R45C-0926-SM-3GAD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51094 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K85636571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13659 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.963692 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles 1.0 0.888749 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null olfactory bulb, principal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05858 strophanthidin-5826 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Clorgiline DeepCoverMOA Drug Mechanisms of Action 1.0 0.34 subcuneiform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.824769 H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null moxisylyte-1846 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AXIN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00472586 Lung adenocarcinoma_LUAD_TCGA-78-7147-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null BRD-K20347026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42439 COLO-792 GDSC Cell Line Gene Expression Profiles -1.0 -1.71487 GTEX-OHPN-0011-R2A-SM-2I5FB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934026 BRD-K01296372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46909 BRD-K05640282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00299 RNA methyltransferase activity GO Molecular Function Annotations 2023 1.0 null intermediate stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08723 intermediate stratum of r3Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07161 Perturb_16765_KO_Dnmt3a_SRP311387 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.1922 BRD-K73689413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5624 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151782_2_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null EGR1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.32143 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.05178 FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.385844 H3K9ac_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171712_0_v_1_scgb1a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kinetoplastid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.626 GSE115395_2_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null alzheimer disease GWASdb SNP-Phenotype Associations 1.0 0.509857 GSE242290_1_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null CORL279 CCLE Cell Line Gene CNV Profiles -1.0 -1.67769 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056497 AF-67-LZ82_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232148 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32337 BRD-K34369474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.55912 OCIMY5 CCLE Cell Line Gene CNV Profiles -1.0 -1.93099 BRD-K82224868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04468 BRD-K26257310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45534 BRD-K58844095 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79032 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles 1.0 1.7003 GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12777 TAF1 ENCODE Transcription Factor Targets 1.0 null nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10564 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lung adenocarcinoma_LUAD_TCGA-38-4632-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07886 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JT-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XGQ4-0426-SM-4AT4I GTEx Tissue Sample Gene Expression Profiles 1.0 1.10302 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE167224,GSE168147_1_v_5_hnrnpk_human RummaGEO Gene Perturbation Signatures -1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K14327064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76675 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.6355 r4 part of trigeminal sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29911 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.32015 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.79284 GSE133763_0_v_2_chd1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QESD-2026-SM-447BI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19276 superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32325 RAD21_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4894-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE218819_2_v_1_kdm5b_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_astrocyte of the cerebellum_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.63647 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.4764 7505_RPS16_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.538131 GTEX-Q2AI-0326-SM-2I3EK GTEx Tissue Sample Gene Expression Profiles 1.0 1.39376 H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUW1-0008-SM-4BOQH GTEx Tissue Sample Gene Expression Profiles 1.0 1.00442 BRD-K65005311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19728 LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.868598 CIITA-25753668-RAJI-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MCF7 CCLE Cell Line Gene CNV Profiles 1.0 1.41687 Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 BRD-K61704278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34116 GTEX-XBEC-1526-SM-4AT68 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10394 r9 portion of ambiguous motor nucleus (postmigratory) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27668 primary motor-sensory cortex (samples)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.884132 CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null GSE151612_0_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X1-01A-12R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null DPY-21335234-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NCIH28 DepMap CRISPR Gene Dependency 1.0 2.72116 GSE74251_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CL-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.16361 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LY-294002-1227 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21714 PAC-1 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.66 10348_ZNF423_ENST00000262383.2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.727589 CAL-72 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 BRD-K33637419 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8781 CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.851126 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GC-40-VJ01_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215833 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.888583 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null HGC-27 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 hl60 HPA Cell Line Gene Expression Profiles -1.0 -1.68688 cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Lung squamous cell carcinoma_LUSC_TCGA-63-7023-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K86722849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47473 Bacterial degradosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.516 GSE207135_2_v_0_sod2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null 1778_COPS2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.568145 MELK_druginhibition_186_GSE50227 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.47195 Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60593 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.1089 TAF7_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_1_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPIC-0726-SM-3GADW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44706 BRD-K14081852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50621 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.31682 FA-63-WI26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.213059 MAX ENCODE Transcription Factor Targets 1.0 null GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91208 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.09742 GSE210101,GSE210114_4_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_10_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null polymorph layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49164 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K13289658 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14421 Perturb_8892_KD_FGFR_SRP099111 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 mebhydrolin-1333 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24227 GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OIZH-2626-SM-2HMJM GTEx Tissue Sample Gene Expression Profiles 1.0 0.972845 GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927484 SW1463 DepMap CRISPR Gene Dependency 1.0 2.22915 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPN-0011-R7A-SM-2I5FI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05828 Small Intestine - Terminal Ileum GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.44618 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050832 GSE190384,GSE190386_0_v_8_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.884733 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065291 BRD-K37262603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06221 BRD-K02118124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.20411 JF-84-QZ64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.279658 primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.61079 GSE183271_2_v_0_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.85625 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X8HC-2726-SM-46MUA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874079 oxymetazoline-1431 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 6511_POGZ_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.566666 KDM5B ENCODE Transcription Factor Targets 1.0 null FLT1_knockdown_111_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.81764 GSE148066,GSE157787_8_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03417 GTEX-RTLS-1326-SM-46MUN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32934 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Netherlands-602-2009(H1N1)_30Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.39391 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02408 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.04389 methyltransferase GeneRIF Biological Term Annotations 1.0 null NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1272 GSE199899_3_v_2_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GB-21-FN58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.384665 showed GeneRIF Biological Term Annotations 1.0 null H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HD-MY-Z COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 hsa-miR-1269 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QLQW-0326-SM-447A8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10307 CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F1-35413990-HUMAN-ARPOSCRPROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null alsterpaullone-7078 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82889 BRD-K03287885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.35899 GSE157904_3_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE216273,GSE216292_14_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null TE8 CCLE Cell Line Gene Expression Profiles 1.0 2.27026 neurodegenerative disease GWASdb SNP-Disease Associations 1.0 0.259023 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null FLI1 ChEA Transcription Factor Targets 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 1.76801 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null AE-72-UP91_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.281634 CTV1DM DepMap CRISPR Gene Dependency 1.0 4.24541 phenindione-1718 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MOLT-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE133213_9_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null r3 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07161 GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57116 fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 1.29295 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SHANK3_KD_GDS4759_338_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Posterior chamber of the eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.885 BRD-K56654013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07714 GSE175787_11_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.56432 superficial stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03227 IST-SL2 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 LY-294002-1177 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-1026-SM-2TF4Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11319 Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.872628 Lobules IV-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85819 BRD-K85110576 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78125 Rpd3L complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.997 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K02388444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.07096 H3K27ac_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_15978_KO_Tsga8_SRP254760 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.2453 59M CCLE Cell Line Gene Expression Profiles 1.0 1.63794 CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49944 CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MCF7 BioGPS Cell Line Gene Expression Profiles 1.0 1.0712 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4713-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles 1.0 3.53526 layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.955449 BRD-K45245001 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01343 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4735-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 DE-48-PP80_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.389028 etodolac-1407 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GW-8510-7080 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.76157 Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K74879991 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08258 BRD-K24422491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76672 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44949 SIX5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.988311 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null metyrapone-3070 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.09742 ESR1 ENCODE Transcription Factor Targets 1.0 null bonemarrow_6b HPA Tissue Sample Gene Expression Profiles -1.0 -2.15299 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-11A-02R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XXEK-1126-SM-4BRUX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03485 Pyramus (VIII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21541 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H-7-5968 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-01A-12R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.903936 peripheral blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.108092 PAX5 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223893_11_v_10_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Integument TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Primary somatosensory area, mouth, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66075 BRD-K04181823 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23082 BRD-K73182084 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64351 SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null thyroid gland HPA Tissue Gene Expression Profiles 1.0 1.41029 M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26821 hsa-miR-92b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 SARS-dORF6_24Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.60073 mantle zone of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07333 Intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 2.169 GTEX-PWCY-2326-SM-2I3EQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.90057 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26045 ESR1_T47D_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE247862,GSE247863_0_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K19103580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.02979 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.17736 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles 1.0 0.910373 GTEX-S341-0008-SM-4AD6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.878513 HCC1954 DepMap CRISPR Gene Dependency 1.0 2.08716 Perturb_161_KO_Kdm4a_SRP192379 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.19 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08942 GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29895 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22793 GSE242333_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null 184A1N4 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.954783 S-adenosyl-L-methionine-dependent methyltransferase InterPro Predicted Protein Domain Annotations 1.0 null HGC27 DepMap CRISPR Gene Dependency 1.0 7.52715 GSE229344_1_v_0_cyb5r3_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_7_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null MET_knockdown_254_GSE38343 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.722078 intermediate stratum of r4Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52951 GSE174498,GSE174500_5_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -3.20819 prochlorperazine-1156 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null erythromycin-2010 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7DV-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 23132-87 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC70 DepMap CRISPR Gene Dependency 1.0 3.83069 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T8EM-0226-SM-3DB7C GTEx Tissue Sample Gene Expression Profiles 1.0 1.16395 thyroid_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.4321 GTEX-RWSA-1426-SM-47JXA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25564 GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.96248 GSE172189_0_v_1_venetoclax_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE219274,GSE219276_3_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null superficial stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08462 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.972306 GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles 1.0 2.12168 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE-8 GDSC Cell Line Gene Expression Profiles 1.0 1.47065 SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.992153 E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.662181 hsa-miR-548e TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 HS 294T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933678 FOSL2 ENCODE Transcription Factor Targets 1.0 null GSE57871_1_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null tRNA (m7G46) methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.402 GTEX-RU72-1426-SM-46MUF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.939558 NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19509 GSE203158_0_v_13_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null KYSE-520 GDSC Cell Line Gene Expression Profiles -1.0 -1.94179 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A97G-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sulfabenzamide-2159 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-7637-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.843028 BRD-K10781609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00841 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.05271 PML ENCODE Transcription Factor Targets 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BC-63-DM76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.26724 PTEN_KD_GDS4759_337_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null PITX1-30713093-EPITHELIAL-HUMAN-TONGUE-SCC ChEA Transcription Factor Targets 2022 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXB4-20404135-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22151 BRD-K04875192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22793 GTEX-XMD1-0011-R1A-SM-4AT4C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19492 GTEX-NFK9-2226-SM-3MJGP GTEx Tissue Sample Gene Expression Profiles 1.0 0.83681 CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.0516 H3K36me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K26383086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22097 ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.28161 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.56149 HCC1419 CCLE Cell Line Gene CNV Profiles 1.0 1.84659 BRD-K82793574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49936 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.70164 digoxin-6724 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VJYA-0426-SM-3GIJK GTEx Tissue Sample Gene Expression Profiles 1.0 1.19357 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE148066,GSE157787_0_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K18179332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30436 H3K14ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null rtqpcr GeneRIF Biological Term Annotations 1.0 null Main olfactory bulb, inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19363 AB-84-PK04_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240478 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE155852_0_v_2_apigenin_mouse RummaGEO Drug Perturbation Signatures -1.0 null KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.316188 FLI1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7 CCLE Cell Line Gene Expression Profiles 1.0 1.48001 NELFE ENCODE Transcription Factor Targets 1.0 null 6555_POLR3A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.543677 H3K14ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KG-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.30264 BRD-K00010082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41141 GSE130437_0_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null AA-86-YY62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214167 SW 48 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.97313 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MD-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K33940145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11052 disease GWASdb SNP-Disease Associations 1.0 0.024058 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 0.85697 r4 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52685 PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null HCC1954 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GSE180185_7_v_1_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.8688 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.49751 intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-1026-SM-48FDX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04364 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null BT16 DepMap CRISPR Gene Dependency 1.0 3.15444 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.82599 MAZ ENCODE Transcription Factor Targets 1.0 null BRD-K13619800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08509 BRD-K74626943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25435 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.34822 SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 OB mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00996 BRD-K21996934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.12653 MAFK ENCODE Transcription Factor Targets 1.0 null BRD-K30379413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74573 NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933678 MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.18254 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.15269 CHD2 ENCODE Transcription Factor Targets 1.0 null OD-96-OP94_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261575 broxyquinoline LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09289 ZNF143 ENCODE Transcription Factor Targets 1.0 null GTEX-QVJO-0008-SM-447AU GTEx Tissue Sample Gene Expression Profiles 1.0 1.08263 GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Diencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.287 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.77563 ZEB1 ENCODE Transcription Factor Targets 1.0 null GTEX-X261-0011-R6B-SM-4E3J8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38475 HuP-T3 GDSC Cell Line Gene Expression Profiles 1.0 1.6812 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28597 Perturb_10404_KO_Mettl14_SRP123442 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.0491 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K13016489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10507 BRD-K30632097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.45225 ChIP_ASH2L_23239880 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K43603649 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09255 BRD-K81916372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29409 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.61838 pallidal part of olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58301 POU2F2 ENCODE Transcription Factor Targets 1.0 null H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intermediate stratum of r5Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46334 H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19291 TC71 DepMap CRISPR Gene Dependency 1.0 4.77695 modification GeneRIF Biological Term Annotations 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.882648 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67244 SRF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null trna metabolic process GO Biological Process Annotations 2015 1.0 null sk-br-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.857153 Gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.922866 Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A3JM-01A-12R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null AD-42-US78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.704601 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K63912037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42124 SRF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1-26981420-C2C12-MOUSE-MUSCLE ChEA Transcription Factor Targets 2022 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8I8-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7/8 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.904 fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.942042 SRF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SSA3-0126-SM-32QPU GTEx Tissue Sample Gene Expression Profiles 1.0 0.945169 GSE119978,GSE180930_2_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NPJ7-0011-R5a-SM-33HBK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863329 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15124 GSE239578_0_v_3_cxadr_mouse RummaGEO Gene Perturbation Signatures 1.0 null non-syndromic intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.318 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27668 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG7-0326-SM-3GILI GTEx Tissue Sample Gene Expression Profiles 1.0 1.15008 Mitochondrial encephalomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.057 GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.987863 CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37025 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE94849_1_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.882197 SPI1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYJK-1626-SM-3NM9J GTEx Tissue Sample Gene Expression Profiles 1.0 0.82629 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11379 GSE154219_0_v_2_cholestyramine_mouse RummaGEO Drug Perturbation Signatures 1.0 null eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-OXRK-0126-SM-3NB1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.20749 DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.370932 10184_ZNF174_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.668708 hsa-miR-4517 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BRD-K10180613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06925 GTEX-R53T-1626-SM-3GAEW GTEx Tissue Sample Gene Expression Profiles 1.0 0.953732 CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null trna GeneRIF Biological Term Annotations 1.0 null GSE175787_13_v_10_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null FLI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null estradiol_homo sapiens_gpl570_gse23610 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33663 vestibular nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30368 HIV - Human immunodeficiency virus infection_T lymphocyte_GSE2504 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -0.713312 EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null GSE216273,GSE216292_0_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null fold GeneRIF Biological Term Annotations 1.0 null GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.80039 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 59M CCLE Cell Line Gene CNV Profiles 1.0 1.56848 UACC893 CCLE Cell Line Gene Expression Profiles 1.0 1.7079 P300-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2827 BF-10-IO69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210029 JUN_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K69826976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.98787 THAP1 ENCODE Transcription Factor Targets 1.0 null PGR-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null BRD-K78574327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.03187 molecular_function GO Molecular Function Annotations 2015 1.0 null breast adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.291722 GSE122215,GSE122217_0_v_2_peg10_mouse RummaGEO Gene Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.925174 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41787 inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.828966 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.61611 mantle zone of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1829 GSE247862,GSE247863_4_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79102 GTEX-S4Z8-0326-SM-3K2AU GTEx Tissue Sample Gene Expression Profiles 1.0 0.935905 BRD-K77718491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9535 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null layer 2 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2128 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07401 Migalastat DeepCoverMOA Drug Mechanisms of Action 1.0 0.34 GTEX-PWO3-0011-R2A-SM-2S1OX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916685 Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17785 GTEX-RVPU-0011-R7A-SM-2XCAB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66722 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-X4XY-1726-SM-46MVO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56527 microbody LOCATE Predicted Protein Localization Annotations 1.0 null triflusal-1717 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE235066_4_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46598 TE-4 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 SLC38A6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00443089 digitoxigenin-4217 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K40964045 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17192 FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.11904 GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57724 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 0.875725 Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TP-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K95678449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34432 SRF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-518d-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 LY-294002-1007 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cytoplasm COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 superficial stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99221 etamivan-1730 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00124 GSE218879_1_v_2_acetaminophen_mouse RummaGEO Drug Perturbation Signatures -1.0 null MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23608 YY1 ChEA Transcription Factor Targets 1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null trichostatin A-2208 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61995 ASH2L-23239880-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV5-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.14644 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEx Muscle 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures -1.0 -9.09664 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEx Esophagus 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures -1.0 -18.9753 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09329 IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.380338 Mitochondrial ribonuclease P complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.284 GSE231648_0_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null AG-013608-5949 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_6957_KO_Ift88_SRP179473 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.07758 Lung squamous cell carcinoma_LUSC_TCGA-66-2782-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.07972 GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33341 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE154961,GSE154963_4_v_0_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE231799_3_v_4_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null Linear nucleus of the medulla Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.94181 ND-15-RC31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.320615 chloramphenicol-1837 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCHEMBL5061501 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.41 POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-4021-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08239 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null granular layer of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00138 NOS-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.847907 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07705 GTEX-UPIC-0926-SM-4IHLV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870153 GSE242367_1_v_0_dpp9_human RummaGEO Gene Perturbation Signatures -1.0 null CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.72238 peroxisome LOCATE Predicted Protein Localization Annotations 1.0 null fallopian tube HPA Tissue Gene Expression Profiles 1.0 1.26085 FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.312373 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3313-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K62288678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16982 molindone-2917 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKBR3 CCLE Cell Line Gene CNV Profiles 1.0 1.86349 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39263 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.50165 GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mcf7 HPA Cell Line Gene Expression Profiles 1.0 2.49231 inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.42077 r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60504 CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K59491482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16023 BRD-K67508052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07012 7559_RRN3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.520671 GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null UF-61-QB73_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.501558 H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19981 IM95 CCLE Cell Line Gene Expression Profiles -1.0 -1.54005 atropine oxide-1370 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null dorsomedial preoptic area, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03288 BRD-K20028052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04904 GSE112762,GSE112767_2_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r4Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09037 0175029-0000-6875 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null intermediate stratum of r3Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56143 U20S BioGPS Cell Line Gene Expression Profiles 1.0 1.28823 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.19392 ELK1 ChEA Transcription Factor Targets 1.0 null BRD-A65806553 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12563 GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12776 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42315 Fields of Forel Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41309 MDAMB231 CCLE Cell Line Gene Expression Profiles -1.0 -1.46047 GTEX-UTHO-2426-SM-4JBHD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857809 PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.989844 BRD-K38493972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05692 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null COV318 CCLE Cell Line Gene CNV Profiles -1.0 -1.8747 BRD-K63189715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.348 GSE223540_1_v_3_anxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null HEPG2 CCLE Cell Line Gene Expression Profiles -1.0 -1.60518 imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XUZC-0926-SM-4BOQF GTEx Tissue Sample Gene Expression Profiles 1.0 0.905733 TRIM28 ENCODE Transcription Factor Targets 1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.085 SRF_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38343532 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04788 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null D-392MG COSMIC Cell Line Gene Mutation Profiles 1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null para-abducens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26587 BF-69-DN58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225159 eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.18603 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LIVF001-008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88308 GSE174498,GSE174500_2_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null pontine reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.49886 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Agranular insular area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71783 GSE112760,GSE112767_1_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.988211 BRD-K61934967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20875 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05371 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.978386 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P78B-1326-SM-3P611 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848104 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.852628 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25718 BD-96-HO33_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296344 CMK115 DepMap CRISPR Gene Dependency 1.0 3.43493 Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null BRD-K12003101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13845 GSE132369,GSE132371_1_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nucleus ambiguus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88045 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.39274 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Main olfactory bulb, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05858 NCI-H2342 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null r6 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64452 BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31727 middle frontal gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1654 GSE139948_3_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SOX2 ChEA Transcription Factor Targets 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HB-24-GP45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.304807 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09106 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null ZBTB33 ENCODE Transcription Factor Targets 1.0 null 16643655-1300GenesList GeneSigDB Published Gene Signatures 1.0 null SOX17-20123909-XEN-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K11573765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03779 GSE174498,GSE174500_5_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.976682 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.449455 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.48975 SOX2-30713093-EPITHELIAL-HUMAN-TONGUE-SCC ChEA Transcription Factor Targets 2022 1.0 null BRD-K60517939 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16493 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dexamethasone_homo sapiens_gpl6244_gse20963 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HDAC2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K56563758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04575 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.45776 BE-13 GDSC Cell Line Gene Expression Profiles -1.0 -1.45473 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VL-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIC JASPAR Predicted Transcription Factor Targets 1.0 null CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 CREB_DEPLETION_GDS3487_41_human_K562 myeloid leukemia cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ES-WA7 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.20248 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199899_4_v_2_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE234637_2_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.00904 medial geniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08639 GABPA_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PU.1-20513432-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174498,GSE174500_0_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEx BloodVessel 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures -1.0 -25.2906 E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K62358193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89356 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.986162 KMOE-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09576 pineal_day BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.886529 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00414849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31933 Ovary TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.243616 BRD-K72135113 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93876 CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139427_2_v_1_ibrutinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-8469-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938583 GSE231648_0_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null sulfapyridine-7151 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE174498,GSE174500_3_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 2791_EXOSC4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.537401 BRD-K98320707 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02223 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78818 GSE172016_2_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null SRF ChEA Transcription Factor Targets 1.0 null benzonatate-1843 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K73834056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50878 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SHSY5Y DepMap CRISPR Gene Dependency 1.0 2.49917 MYC-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null globose nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07813 GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15366 GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33763 ovary HPA Tissue Protein Expression Profiles -1.0 -2.15794 H3K79me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_0_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5028-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.315 GTEX-XUW1-1726-SM-4BOOZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07125 CREB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BJAB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.84691 Adrenocortical carcinoma_ACC_TCGA-OR-A5J9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04471 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.837248 CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.04511 GTEX-V955-0426-SM-3GAEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.20003 HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.35074 CA-10-RU23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.391519 UC-00-QA88_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256956 GTEX-XV7Q-0226-SM-4BRVL GTEx Tissue Sample Gene Expression Profiles 1.0 0.948197 dorsolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01737 BRD-K29935988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93023 NRF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null GSE74251_2_v_3_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null PSS008 DepMap CRISPR Gene Dependency 1.0 6.52104 SNU761 DepMap CRISPR Gene Dependency 1.0 3.00199 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE48812_11_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null AR-19668381-PC3-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GW-8510-7067 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EST1-17652178-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052734 UA-39-TN76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.61254 CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20784 ascorbic acid-1610 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K18189580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05257 GTEX-XBED-0008-SM-47JWO GTEx Tissue Sample Gene Expression Profiles 1.0 1.09889 tRNA modification in the nucleus and cytosol Reactome Pathways 2024 1.0 null r8 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0262 H2AFZ ENCODE Transcription Factor Targets 1.0 null flunixin-2552 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A14878925 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13922 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.96974 GTEX-R53T-0226-SM-48FEH GTEx Tissue Sample Gene Expression Profiles 1.0 0.982054 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SJ-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.013585 Skin Cutaneous Melanoma_SKCM_TCGA-HR-A5NC-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21996189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03864 GSE239844_7_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.75897 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25514 trna processing GO Biological Process Annotations 2015 1.0 null abnormality of nervous system morphology GWASdb SNP-Phenotype Associations 1.0 0.067346 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAUZ-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWN1-2626-SM-2I3FH GTEx Tissue Sample Gene Expression Profiles 1.0 0.986133 Vaginal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.853 RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17952126-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3QU-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null SMC1-22415368-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEx Muscle 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures -1.0 -21.4078 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04602 SOX17-20123909-XEN-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null sirolimus-1242 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.79948 SAM-dependent methyltransferase TRM5/TYW2-type InterPro Predicted Protein Domain Annotations 1.0 null GSE130956_0_v_1_icaritin_human RummaGEO Drug Perturbation Signatures -1.0 null orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.851846 SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.995664 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null precuneus, right, superior lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.901062 BRD-K32893898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21099 cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.78282 BRD-K28294686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41548 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.661409 H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Dom34-Hbs1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.959 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.873866 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31214 SW1990 DepMap CRISPR Gene Dependency 1.0 2.98352 GTEX-PX3G-0006-SM-33HBQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842505 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07226 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.83749 SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09788 624 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.82482 decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K18352607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08862 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61751 primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.00034 STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFON-0001-SM-3P61W GTEx Tissue Sample Gene Expression Profiles 1.0 0.949575 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.61828 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.85212 GTEX-P4PP-1026-SM-3NM9O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09486 Brain_Germinal_Matrix Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.50836 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66539236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35236 cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.30453 Ribonuclease P complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.284 BRD-K35383890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82855 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50595 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.54231 KP-4 GDSC Cell Line Gene Expression Profiles 1.0 1.46836 GE-63-WI86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.34122 CNOT3-19339689-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38101 FOXP3_ABLATION_GDS2525_64_mouse_mature regulatory T cells (Treg) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null HT-144 GDSC Cell Line Gene Expression Profiles 1.0 1.54605 GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -2.0363 epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058766 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 OPM2 DepMap CRISPR Gene Dependency 1.0 3.11538 GSE80098,GSE80366_0_v_5_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K13085116 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06073 RCOR1 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A72W-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JEKO-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles 1.0 2.6596 GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3262 Acute Myeloid Leukemia_LAML_TCGA-AB-2913-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 2.169 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039224 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.67394 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SF-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 H3K9ac_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE175787_13_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12870_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52121 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.411 ventrolateral prefrontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53486 BRD-K18385869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15773 fallopiantube_8e HPA Tissue Sample Gene Expression Profiles 1.0 1.24538 BRD-K19962165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28548 BRD-K75037209 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22037 CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HGC27 CCLE Cell Line Gene Expression Profiles 1.0 1.48492 mRNA cap binding complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.832 KDM4A ENCODE Transcription Factor Targets 1.0 null tamoxifen-2212 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K52973286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09426 inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.991573 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.900025 GTEX-TSE9-0011-R7A-SM-3DB7P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850781 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.19539 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.92247 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21544408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87001 Skin Cutaneous Melanoma_SKCM_TCGA-RP-A694-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85418917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.29853 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-REY6-1226-SM-48FDR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17315 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE231641_0_v_1_robo1_mouse RummaGEO Gene Perturbation Signatures -1.0 null EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-2626-SM-33HC9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06303 trichostatin A-6143 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LXR-22292898-THP-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K18ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K61555339 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30496 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SYK_druginhibition_287_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.95291 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864809 H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K91361836 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22141 FA-65-UA27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.302265 BRD-K31010207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31588 BRD-K36952018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56662 TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_ZFP42_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null droperidol-1290 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.888916 CTCF_WI38_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE212486,GSE212488_2_v_3_gata4_mouse RummaGEO Gene Perturbation Signatures 1.0 null CAY10683 DeepCoverMOA Drug Mechanisms of Action 1.0 0.27 Retrosplenial area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08523 BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.638754 E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null mitoxantrone-5354 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K05831864 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41671 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.90387 Mating projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.595 ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NFK9-0726-SM-2HMJW GTEx Tissue Sample Gene Expression Profiles 1.0 1.32343 liver_a HPA Tissue Sample Gene Expression Profiles -1.0 -0.922185 Translation initiation ternary complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.339 H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.289711 bacampicillin-1337 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45795 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SET2 DepMap CRISPR Gene Dependency 1.0 2.39144 TRPV5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00549847 GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles 1.0 1.12423 TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CL40 CCLE Cell Line Gene Expression Profiles -1.0 -2.25484 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231648_4_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null mantle zone of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64452 DA-19-JA87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.478935 CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.896546 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02375 BRD-K68160857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9578 GSE154936_3_v_2_remdesivir_human RummaGEO Drug Perturbation Signatures 1.0 null SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 1.77744 pepstatin-1328 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 451LU COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_10_v_6_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37865727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2237 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.83708 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null IA-27-CK10_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283437 nucleus of the diagonal band, left, horizontal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.880747 HCC2935 CCLE Cell Line Gene CNV Profiles -1.0 -1.8104 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null NLGN3_KD_GDS4759_336_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE132369,GSE132371_2_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Set3 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.764 AR ChEA Transcription Factor Targets 1.0 null GTEX-QMR6-0011-R1A-SM-32PKW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19992 GSE151782_4_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3229 CTCF_epithelial cell of esophagus_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF1 ENCODE Transcription Factor Targets 1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11347 GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.0404 H3K27ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.829668 C3A GDSC Cell Line Gene Expression Profiles -1.0 -1.47974 hsa-miR-490-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 BRD-K05277255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04578 GTEX-OOBJ-0526-SM-48TDK GTEx Tissue Sample Gene Expression Profiles 1.0 0.929272 GSE142430_3_v_1_prmt5_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K53224741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1249 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26035 1,4-chrysenequinone-7139 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GW-8510-7062 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-328 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BFTC-905 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K80877725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0819 liminal part of the r8 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07333 WT1-25993318-PODOCYTE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null imatinib_homo sapiens_gpl96_gds3045 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BT12 DepMap CRISPR Gene Dependency 1.0 2.96408 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KNS42 CCLE Cell Line Gene CNV Profiles -1.0 -1.57437 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28917 posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03514 MKN28 COSMIC Cell Line Gene Mutation Profiles 1.0 null striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11721 wybutosine biosynthetic process GO Biological Process Annotations 2023 1.0 null GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles 1.0 1.19636 NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.64899 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.829396 hsa-miR-3646 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A953-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K83721789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10448 GSE186810,GSE186813_2_v_5_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33819 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.927739 GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28472 N-acetyl-L-leucine-3085 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.18449 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47148 GTEX-XXEK-1726-SM-4BRVB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2955 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08329 BRD-K59913416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09704 cuneate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.43075 GSE133764_1_v_0_chd2_human RummaGEO Gene Perturbation Signatures -1.0 null bewo HPA Cell Line Gene Expression Profiles -1.0 -1.02338 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Culmen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85383 MDA MB435 BioGPS Cell Line Gene Expression Profiles 1.0 1.38449 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86094 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.20929 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.63851 Fatty Liver CTD Gene-Disease Associations 1.0 1.14302 intermediate stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99502 superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08046 MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null corticoid layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53458 GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles 1.0 1.09377 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2BK20ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Eukaryotic translation elongation factor 1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.374 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32546 HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null REST ENCODE Transcription Factor Targets 1.0 null CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Galloway-Mowat syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.138 NCI-H2023 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839409 posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.80096 GTEX-X62O-2226-SM-46MW3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15146 cytoplasmic part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 BDCA4+_DentriticCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.944346 SOX2-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null azathioprine-2028 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-2126-SM-447AE GTEx Tissue Sample Gene Expression Profiles 1.0 0.895596 HCC1419 DepMap CRISPR Gene Dependency 1.0 5.17825 BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TTF2-22483619-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null captopril-1988 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03041 OMC-1 GDSC Cell Line Gene Expression Profiles -1.0 -3.13286 Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21409 Brain Lower Grade Glioma_LGG_TCGA-HT-7475-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.5389 Lung adenocarcinoma_LUAD_TCGA-MP-A4T8-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE119978,GSE180930_6_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.49459 RARB-27405468-CHIP-SEQ-BRAIN-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GATA2-19941826-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-OHPN-0011-R3A-SM-2I5FC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43244 EW-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.04538 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053657 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null encoding GeneRIF Biological Term Annotations 1.0 null 9453_TXNDC9_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.915894 GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles 1.0 1.26435 cingulate gyrus, parietal part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14573 amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01787 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00735 BRD-K27540772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88827 BRD-K14987634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4592 POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3308-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCP1 CCLE Cell Line Gene CNV Profiles -1.0 -1.60477 GTEX-XUZC-0126-SM-4BOO6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41536 CZC-25146 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.32 H3K4me1_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K50432649 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63691 BRD-K44012257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88307 GSE239844_7_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K05802716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51537 BC-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GSE174498,GSE174500_3_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null HCC1187 CCLE Cell Line Gene CNV Profiles -1.0 -2.42963 GSE213588_10_v_13_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K77743611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61158 Medial amygdalar nucleus, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.9642 8651_TAF10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.504595 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7409-01A-31R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K77480803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12934 Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null HT29 DepMap CRISPR Gene Dependency 1.0 3.38434 BRD-K20039572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55397 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.964575 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Main olfactory bulb, granule layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03986 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYB-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NLGN1_KD_GDS4759_335_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-X4XY-1626-SM-46MVN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.940667 NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.89174 POLR2A_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12771 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89709 Brain Lower Grade Glioma_LGG_TCGA-S9-A7QX-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199255,GSE199356_4_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-0926-SM-46MV7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57896 r7 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99221 BRD-K77023196 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96326 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ciclopirox-6677 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A75409952_wortmannin_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-0926-SM-4DXSW GTEx Tissue Sample Gene Expression Profiles 1.0 0.875291 FLI1-21867929-CD8-MOUSE ChEA Transcription Factor Targets 2022 1.0 null VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.67162 MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32796 AP1S2 ChEA Transcription Factor Targets 1.0 null GW-8510-7085 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC1428 CCLE Cell Line Gene CNV Profiles 1.0 1.40716 hsa-miR-3127-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.956808 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89549 MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05594 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5143 Nucleus of the solitary tract, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3847 KURAMOCHI CCLE Cell Line Gene Expression Profiles 1.0 1.52834 Kidney Chromophobe_KICH_TCGA-KN-8419-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null Heschl's gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.862513 CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K35863275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59652 BRD-K78202004 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.58472 GSE154337_0_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052133 famprofazone-2174 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EE-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sno(s)RNA-containing ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.122 CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 1 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64614 GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38398 pheniramine-1992 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-NPJ7-0011-R1a-SM-3GACT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946133 MDA-MB-231 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.73628 BRD-K16149312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22836 Adrenalgland BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.54049 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18035 EFM-192A COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 BRD-K54272776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77254 dorsolateral prefrontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25263 YY1 ENCODE Transcription Factor Targets 1.0 null Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.003 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62104 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K14428604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16945 Magnocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62227 KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.14851 r5 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70529 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186460_0_v_2_baricitinib_human RummaGEO Drug Perturbation Signatures 1.0 null chr8_124456259_G_T_b38 GTEx eQTL 2025 1.0 1.98604 fusiform gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17689 intermediate stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51978 JUN ENCODE Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IK-01A-32R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null methyldopate-2940 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914424 RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null colon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null r7 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15024 liver HPA Tissue Protein Expression Profiles -1.0 -1.229 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null fallopian tube GTEx Tissue Gene Expression Profiles 1.0 1.02826 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.41737 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K35123860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28529 GSE160246_0_v_5_cpeb4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TSE9-2226-SM-4DXUR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02122 Prostate adenocarcinoma_PRAD_TCGA-M7-A725-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE-150 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.681 MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902866 HOXB4-20404135-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SN8G-0226-SM-4DM6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.03558 TCF12 ENCODE Transcription Factor Targets 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00476 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE174498,GSE174500_0_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null HCT116 BioGPS Cell Line Gene Expression Profiles 1.0 0.932869 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-0226-SM-2I5FV GTEx Tissue Sample Gene Expression Profiles 1.0 0.96088 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null skbr3 HPA Cell Line Gene Expression Profiles 1.0 1.54583 BRD-A66025870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22029 H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35451338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63283 supragenual nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.86331 GTEX-XLM4-0011-R9A-SM-4AT45 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13546 plexiform layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38557 H-7-5963 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HIPK2_knockdown_106_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.64847 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 0.882424 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.406 GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles 1.0 1.47356 GSE218819_3_v_4_kdm5b_human RummaGEO Gene Perturbation Signatures -1.0 null UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.58762 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1272 GSE210505_0_v_1_sox1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K58270905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8028 alsterpaullone-7051 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22933 GSE235701,GSE261434_0_v_1_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null MECP2_KD_GDS4759_334_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19805 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-A55025683 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51944 GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.23974 r5 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14401 BRD-K85347477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11982 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null vigabatrin-2452 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null HS-578-T COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.876261 EZH2 ENCODE Transcription Factor Targets 1.0 null GTEX-XOT4-1426-SM-4B65T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00998 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.15992 C2BBE1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.908123 BRD-K38040305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27004 subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46008 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.42828 GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920258 TC71 CCLE Cell Line Gene Expression Profiles 1.0 1.95727 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE123943_4_v_3_sox1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K02517738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40171 CF-24-KQ98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.303013 GSE240258_0_v_1_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null trnaphe GeneRIF Biological Term Annotations 1.0 null TTF2-22483619-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09431 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4302 RNA methyltransferase activity GO Molecular Function Annotations 2025 1.0 null ellipticine-5779 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Folic Acid CTD Gene-Chemical Interactions 1.0 null GSE203158_0_v_8_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XMD1-0011-R2B-SM-4AT5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42229 E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7056-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K91655763 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22669 BRD-K73769678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.415 GTEX-SJXC-0326-SM-2XCFI GTEx Tissue Sample Gene Expression Profiles 1.0 0.841848 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6V9-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.21595 TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53583 WB-38-DZ32_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.258731 E2F1 ChEA Transcription Factor Targets 1.0 null DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.491821 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE108614,GSE108615_3_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K44167510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10753 TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AU565 CCLE Cell Line Gene Expression Profiles 1.0 1.50899 BRD-K21386594 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36688 LD-37-JE11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.280805 ACHN BioGPS Cell Line Gene Expression Profiles -1.0 -1.55222 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K70276322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.08914 YY1-21170310-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K08438266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42613 BRD-K33787033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21191 using GeneRIF Biological Term Annotations 1.0 null GTEX-UPK5-2326-SM-3P5Z8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.941793 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01051 GSE213588_8_v_11_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null IZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03036 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.040678 KYSE520 CCLE Cell Line Gene Expression Profiles -1.0 -1.57847 all GWASdb SNP-Phenotype Associations 1.0 0.028292 intermediate stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07389 BRD-K11715561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49999 BRD-K71005143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14019 GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.17455 Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 BRD-K88802328 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.28222 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE98964_1_v_4_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Polysomal ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.91 cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE242290_1_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null FF-22-NB12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219192 STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMK-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.668359 primary auditory cortex (core)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.881493 BRD-K31503053 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.97586 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K43628610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1993 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.74496 10623_ZNF774_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.58935 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.627 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE-8 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K69350688 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19321 GSE121043_0_v_1_aldh1a1_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K63800697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2724 HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.604735 YD8 DepMap CRISPR Gene Dependency 1.0 3.34608 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A196-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.66606 lateral part of MM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01283 striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.88543 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EW-1 GDSC Cell Line Gene Expression Profiles 1.0 1.70679 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.861426 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 2.10648 ZFP42-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-1326-SM-3NB2S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28243 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16322 posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.51922 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.902732 todralazine-1841 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.99874 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r1BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0162 SK-MEL-5 GDSC Cell Line Gene Expression Profiles 1.0 1.62839 HEPG2 BioGPS Cell Line Gene Expression Profiles -1.0 -1.23757 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K17854062 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14875 IA-27-CK10_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.447027 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.05783 GSE134029_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null intermediate stratum of r8Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02373 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 0.944843 GSE242290_3_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null r10 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07834 GTEX-XGQ4-0004-SM-4AT5S GTEx Tissue Sample Gene Expression Profiles 1.0 1.33431 BRD-K26140483 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52235 mitochondrion COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-SIU8-0008-SM-4BRUC GTEx Tissue Sample Gene Expression Profiles 1.0 1.20551 BRD-K49467822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82668 BRD-K64183190 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04228 hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.59633 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adipose - Visceral (Omentum) GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.76914 VDR ChEA Transcription Factor Targets 1.0 null KC-45-DZ26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223087 HT-144 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.8942 ChIP_SOX17_20123909 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null lateropallial prepiriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06147 GTEX-OOBK-1026-SM-48TC2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04707 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08728 periventricular stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09534 ELF1 ENCODE Transcription Factor Targets 1.0 null FA-92-JL46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.374615 AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40731 inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26417 GTEX-WL46-0011-R7A-SM-3LK7X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858434 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WL46-0526-SM-3LK7W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.884158 H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE225901_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null ERBB2_knockdown_237_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.69862 GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06403 H3K9me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Parvicellular reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.98112 IZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.78051 KM12 GDSC Cell Line Gene Expression Profiles -1.0 -1.82433 Brain Lower Grade Glioma_LGG_TCGA-FG-A70Y-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A388 DepMap CRISPR Gene Dependency 1.0 2.47856 BRD-K81082554 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09196 HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.03845 BRD-K75985122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61646 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7851 inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.20912 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.905326 CAOV-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Trachea BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.10966 CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DICER1_KO_GDS4504_586_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE100863,GSE100864_3_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08639 GTEX-TSE9-0226-SM-3DB84 GTEx Tissue Sample Gene Expression Profiles 1.0 0.938056 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14173 GSE219195_4_v_2_rbm12_human RummaGEO Gene Perturbation Signatures -1.0 null alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K97949309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06731 SB-94-ZA83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.334038 GE-34-TW62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.420445 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.002 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W9-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null GTEX-QMR6-0008-SM-447AV GTEx Tissue Sample Gene Expression Profiles 1.0 1.14801 hsa-miR-4733-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null clofazimine-1624 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42298 Prostate adenocarcinoma_PRAD_TCGA-YL-A8S9-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K00955582 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07465 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -3.03605 breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.438658 GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 0.940232 BRD-K74391203 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83555 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14728 GSE213588_9_v_11_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null PL4 DepMap CRISPR Gene Dependency 1.0 2.09207 GSE71529,GSE71558_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K15708264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21979 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JARID1A-20064375-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r9 part of the lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35738 cognitive disorder GWASdb SNP-Disease Associations 1.0 0.100663 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27633 GSE126127_0_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE58724_3_v_4_oxymetholone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE152441,GSE152442_6_v_3_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17514 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41521 H3K4me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r7 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46968 TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tRNA modification GO Biological Process Annotations 2023 1.0 null GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1171 GTEX-QV31-0008-SM-447AT GTEx Tissue Sample Gene Expression Profiles 1.0 1.33892 BRD-K84517695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12379 Nucleus ambiguus, dorsal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.27371 large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K18368161 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91787 GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 2.23141 corticoid layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35991 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05489 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE101112_0_v_4_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE174498,GSE174500_2_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null blood GTEx Tissue Gene Expression Profiles -1.0 -0.903756 soft tissue HPA Tissue Protein Expression Profiles -1.0 -1.11571 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.53367 SIRT6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069722 CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K63730594 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33239 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67803 GTEx Muscle 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures -1.0 -11.5809 EBF1 ENCODE Transcription Factor Targets 1.0 null heterocycle metabolic process GO Biological Process Annotations 2015 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null BRD-K76620631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00178 acebutolol-1911 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null phenylalanine-tRNA ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.882 CAMA-1 GDSC Cell Line Gene Expression Profiles 1.0 1.50031 GSE114013,GSE114014_0_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-P4PQ-1026-SM-3NMCN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14897 GSE186223,GSE186224_6_v_3_hmces_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K77425312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.00232 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.65991 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles 1.0 1.1181 3774_HIST1H3H_ENST00000369163.2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.537249 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040393 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199255,GSE199356_3_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.33661 alzheimer's disease GWASdb SNP-Disease Associations 1.0 0.600187 GSE48812_2_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null estradiol_homo sapiens_gpl571_gds4052 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.59492 POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of mental health GWASdb SNP-Disease Associations 1.0 0.043989 HPBALL CCLE Cell Line Gene Expression Profiles -1.0 -1.71455 BRD-K40838215 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23565 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterior olfactory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.31114 anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.24751 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 600MPE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.992033 CREB1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153871_4_v_2_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03833 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00803 BRD-K76482408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32948 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sirolimus-1162 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null doxorubicin-5671 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TML8-0008-SM-4DXUI GTEx Tissue Sample Gene Expression Profiles 1.0 0.875403 GTEX-SNOS-0226-SM-32PLR GTEx Tissue Sample Gene Expression Profiles 1.0 1.06403 BRD-K23316636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45729 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null sirolimus_homo sapiens_gpl2895_gse16944 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-3690 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 MN-60 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.89815 HCC1419 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GSE175787_13_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null carbamazepine-1847 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mantle zone of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05858 GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.06723 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28858 Accessory olfactory bulb, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29934 GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles 1.0 1.2763 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TTF2 ChEA Transcription Factor Targets 1.0 null Olfactory tubercle, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02478 TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.03414 BE-27-RQ61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.30191 CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72015 GSE242367_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ERG-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73025859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1098 EGR1 ENCODE Transcription Factor Targets 1.0 null lateral part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27935 H3K27ac_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K56ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEx Brain 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures -1.0 -15.8482 CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.01503 RUNX1-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.83832 JURLMK1 DepMap CRISPR Gene Dependency 1.0 5.19313 Acute Myeloid Leukemia_LAML_TCGA-AB-2879-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K01083922 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07851 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.64677 BRD-A21168039 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53397 tRNA methyltransferase activity GO Molecular Function Annotations 2023 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0526-SM-2I3EH GTEx Tissue Sample Gene Expression Profiles 1.0 1.39909 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.76264 GTEX-VUSG-0008-SM-4KL24 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40747 SNU119 CCLE Cell Line Gene Expression Profiles 1.0 1.60905 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ccd34lu TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.424 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Triclabendazole DeepCoverMOA Drug Mechanisms of Action 1.0 0.35 BRD-K96979108 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23901 GTEx Brain 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures -1.0 -9.37182 BRD-K01995700 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45333 Methionine CTD Gene-Chemical Interactions 1.0 null GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.976045 GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69408 H4K20me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T4-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 22RV1 COSMIC Cell Line Gene Mutation Profiles 1.0 null KURAMOCHI CCLE Cell Line Gene CNV Profiles 1.0 1.34544 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOTO-0826-SM-4B65O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03713 Lung squamous cell carcinoma_LUSC_TCGA-22-5481-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226249_2_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55717 Nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 2.169 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-OIZH-1326-SM-3NB1H GTEx Tissue Sample Gene Expression Profiles 1.0 0.868539 H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AA-48-XT80_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214171 ESR1_T47D_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.889712 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K59100858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63002 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0011-R8a-SM-2HMLG GTEx Tissue Sample Gene Expression Profiles 1.0 0.896964 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lateral medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.77081 chloroquine-1719 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZC3H11A ENCODE Transcription Factor Targets 1.0 null CESS cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.713 NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -1.94346 STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MFM-223 GDSC Cell Line Gene Expression Profiles 1.0 3.01935 GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles 1.0 1.24119 hsa-miR-646 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.44024 BRD-K48516290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20807 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K97562463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07419 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5455-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles 1.0 1.48789 flunarizine-2381 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WYBS-1226-SM-3NM9N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42002 BRD-K52731672 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8966 AE-61-UO01_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278142 GSE148066,GSE157787_3_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.78844 BRD-K67535324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15812 H3K36me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.91133 CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1115 CC-21-IE22_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236831 KAT2A ENCODE Transcription Factor Targets 1.0 null BRD-K60807536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57334 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null bonemarrow_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.04002 BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265907 GSE148657_3_v_1_cd44_human RummaGEO Gene Perturbation Signatures 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42874 K562 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.65725 MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039925 inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.864334 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2827 POU2F2 JASPAR Predicted Transcription Factor Targets 1.0 null dementia GWASdb SNP-Disease Associations 1.0 0.352731 BRD-K63864604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84671 GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.68947 CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Gustatory areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36455 AU565 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.657635 BRD-K74933734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0199 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.62733 H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Twig TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.512 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null allantoin-1842 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.61392 CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPN-0011-R4A-SM-2I5FD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.976435 GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828041 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NE-06A-21R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 2.07738 H2AK5ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K36me3_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K98018160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35559 Metabolism of RNA Reactome Pathways 2024 1.0 null hsa-miR-519c-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 EB-67-WB79_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.297442 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null phenacetin-2471 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K32960568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38702 GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15039 eRF1 methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.203 Uterine Carcinosarcoma_UCS_TCGA-QN-A5NN-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06431 embryoday9.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.880494 Primary somatosensory area, mouth, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.61397 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6956-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.620564 membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 2.169 BRD-K19183365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55211 BRD-K45762887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13098 LY-294002-6175 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEY DepMap CRISPR Gene Dependency 1.0 2.73705 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null bonemarrow_6c HPA Tissue Sample Gene Expression Profiles -1.0 -0.877083 BRD-K41729242 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.08967 GSE175787_4_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K16800391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00216 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ1-0126-SM-33HB3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04307 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62339 H4K91ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-QV31-0226-SM-447BO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10834 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z4-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE130956_2_v_1_icaritin_human RummaGEO Drug Perturbation Signatures -1.0 null geldanamycin-1169 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K25328765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.30206 anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61953 GTEX-WHPG-0226-SM-3NMB9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.99872 BRD-K01286616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.875 CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r9 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89315 thyroid GTEx Tissue Gene Expression Profiles 1.0 1.65417 tRNA methylation GO Biological Process Annotations 2025 1.0 null layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.38668 GSE123002_0_v_1_srsf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE239541_11_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE224969,GSE224971_3_v_1_chtop_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17308 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09727 GSE210870_0_v_2_snai1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE57871_6_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73061 lateral tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43078 GTEX-QMR6-0011-R7A-SM-32PKL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03668 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.3337 H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4740-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 BRD-K89277562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19308 GSE242290_1_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null Retrochiasmatic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09055 JHOS-3 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 5933_OGT_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.550154 hsa-miR-526a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.028312 Lung squamous cell carcinoma_LUSC_TCGA-22-5471-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H28 GDSC Cell Line Gene Expression Profiles -1.0 -1.46129 Olfactory tubercle, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12771 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.98485 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ1-0008-SM-4DXSO GTEx Tissue Sample Gene Expression Profiles 1.0 2.17898 GSE151612_4_v_11_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7153-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-61 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GSE102505_4_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAMA1 CCLE Cell Line Gene Expression Profiles 1.0 1.58842 HB-01-ZU75_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.284276 CTCFL_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles 1.0 0.898553 7449_RPL23A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.621876 inner CP in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16035 H3K9me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K78009480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3769 GSE102132_2_v_1_irf3_human RummaGEO Gene Perturbation Signatures 1.0 null MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89089 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.43651 GSE175787_11_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Declive (VI) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67206 ETS1 ENCODE Transcription Factor Targets 1.0 null NCIH211 DepMap CRISPR Gene Dependency 1.0 3.08549 TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC ChEA Transcription Factor Targets 2022 1.0 null Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.32 r6 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.37473 mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31727 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JD-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rna GeneRIF Biological Term Annotations 1.0 null BRD-K83013052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39728 TE-10 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 CREB1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2793_EXOSC6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.565313 GSE133213_9_v_13_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null EB-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.96072 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21714 BRD-K86694287 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.10899 BRD-K91588908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0407 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLI3T_Lipofectamine transfection_GDS4346_616_human_Panc-1 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.12891 SRF ENCODE Transcription Factor Targets 1.0 null catalytic activity GO Molecular Function Annotations 2015 1.0 null S-Adenosylmethionine HMDB Metabolites of Enzymes 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QESD-1726-SM-2S1R7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35538 CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0011-R1A-SM-3DB7E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857049 BRD-K22789469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17855 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19004 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990284 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RK-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.05423 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KAT2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE134375_0_v_2_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null cerebellum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.976033 H3K18ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null XC-81-LR46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266712 External cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23923 ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TD-69-UA90_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.397977 Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.25591 Brain Lower Grade Glioma_LGG_TCGA-DB-A64X-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62047 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22374 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE112762,GSE112767_1_v_0_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null hepg2 HPA Cell Line Gene Expression Profiles -1.0 -1.08609 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19J-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NC-27-AD53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.500876 Perturb_9209_KO_Cic_SRP076421 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.45496 thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.437906 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BC-1 GDSC Cell Line Gene Expression Profiles 1.0 1.47356 ISHIKAWA(HERAKLIO)02ER- COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.87211 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SPSB1 Hub Proteins Protein-Protein Interactions 1.0 null 6794_PRPF38A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.639045 H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H-7-5941 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null nucleic acid metabolic process GO Biological Process Annotations 2015 1.0 null TE4 CCLE Cell Line Gene Expression Profiles 1.0 1.38954 GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70688 GSE231648_0_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFJO-0008-SM-4LVN7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.930347 r4 part of vestibular sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21976 CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K22487336 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13252 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51901 BRD-K52872067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.50582 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.17859 EP300_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pentetrazol-2092 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XOTO-0011-R6B-SM-4B65X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.978615 AB-71-CI37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.461757 BRD-K04714488 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8636 BE-27-RQ61_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.511217 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null streptomycin-1578 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ELK1-19687146-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null BRD-K77221985 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76192 liver GTEx Tissue Gene Expression Profiles -1.0 -1.80117 THAP1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SRF-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE137177_2_v_0_folic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231648_4_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16273 GSE174498,GSE174500_2_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K37387086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30887 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MFM-223 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 GSE148066,GSE157787_5_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Translation release factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.915 GSE245270_1_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null Get-1_Deficiency_GDS2629_161_mouse_embryonic skin GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K62017257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37064 MYBL2 ChEA Transcription Factor Targets 1.0 null GTEX-TSE9-0011-R9A-SM-3DB7Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0783 CHLA57 DepMap CRISPR Gene Dependency 1.0 2.05263 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52324 GSE113267_0_v_1_rfx7_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WHSC1 ENCODE Transcription Factor Targets 1.0 null GTEX-R55E-0011-R11A-SM-2TC6I GTEx Tissue Sample Gene Expression Profiles 1.0 0.85696 SNU61 CCLE Cell Line Gene CNV Profiles 1.0 1.94613 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2351 GSE163282_12_v_8_aspirin_human RummaGEO Drug Perturbation Signatures 1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040233 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 990_MOSMO_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.552774 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FS-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Artery disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.717 GTEX-WRHU-1026-SM-4E3ID GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03597 GTEX-Q734-0126-SM-48U1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.29193 POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lactic acidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50I-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCRT CEM BioGPS Cell Line Gene Expression Profiles -1.0 -2.16609 superior frontal gyrus, right, medial bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.891453 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null carteolol-1340 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ONECUT1 Pathway Commons Protein-Protein Interactions 1.0 null GSE175787_5_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-POYW-1226-SM-2XCEP GTEx Tissue Sample Gene Expression Profiles 1.0 1.26967 MOTN1 CCLE Cell Line Gene CNV Profiles -1.0 -1.92352 Colon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU3F1-26484290-ESCSS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.46602 GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.900097 GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U4-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null trimethobenzamide-2002 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.5244 Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YN-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K80880506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07213 CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE164874_5_v_14_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.35156 KDM5A ChEA Transcription Factor Targets 1.0 null HCC1428 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.425 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCIH441 DepMap CRISPR Gene Dependency 1.0 5.23556 QD-39-YV36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207651 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null alvespimycin-1154 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XBED-0126-SM-47JY7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.68166 Perturb_2216_OE_H3f3a_SRP289821 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.46299 M059K CCLE Cell Line Gene CNV Profiles -1.0 -1.35281 rna metabolic process GO Biological Process Annotations 2015 1.0 null Mitochondrion COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.549 HEL DepMap CRISPR Gene Dependency 1.0 3.67627 BRD-K39979888 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64806 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148066,GSE157787_3_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lobule III Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08288 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14213 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29H-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pancreas_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.29295 BRD-K78211834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62668 GTEX-S32W-2526-SM-2XCB8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.865592 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34604637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43839 RNA methylation GO Biological Process Annotations 2025 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV MA15_Day4-C57BL-6_None_GSE40824 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.0675 MYC_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09909 20068109-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intermediate stratum of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27668 GSE102505_6_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5751-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CALU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.36594 BRD-K13164804 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31544 Inferior salivatory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.58769 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21476 H-7-5936 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null IRF2 JASPAR Predicted Transcription Factor Targets 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.945105 Kidney Chromophobe_KICH_TCGA-KL-8337-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K38248920 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18166 CHEMBL1643306 DeepCoverMOA Drug Mechanisms of Action 1.0 0.28 smooth muscle HPA Tissue Protein Expression Profiles -1.0 -2.15794 CBX3 ENCODE Transcription Factor Targets 1.0 null GSE152441,GSE152442_6_v_5_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U3ZN-0326-SM-3DB86 GTEx Tissue Sample Gene Expression Profiles 1.0 0.837458 Prestwick-981-3125 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.96556 UBTF ENCODE Transcription Factor Targets 1.0 null JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.564854 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TG-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K77407030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12012 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Synthesis of wybutosine at G37 of tRNA(Phe) Reactome Pathways 2024 1.0 null BRD-K52391588 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39691 GSE146982_4_v_1_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76309489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75534 wybutosine biosynthetic process GO Biological Process Annotations 2025 1.0 null SNU61 CCLE Cell Line Gene Expression Profiles 1.0 1.37397 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.922606 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.49525 GSE168797_1_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-5307-01A-01R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.898685 HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27691 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A96537953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1667 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65734 H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WZTO-0426-SM-3NM99 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829945 BRD-K05474024 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02428 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBK-0008-SM-3NB27 GTEx Tissue Sample Gene Expression Profiles 1.0 0.984672 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C6-06A-12R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K11307720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85895 doxylamine-1893 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null r1 part of intermediate nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16849 SRF_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-19915707-AK7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE238116_3_v_0_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null catalytic activity, acting on a tRNA GO Molecular Function Annotations 2023 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A857-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175787_8_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null cellular process GO Biological Process Annotations 2015 1.0 null GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 0.874442 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FE-64-KC49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.397855 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Vermal regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03466 MIR140_Silencing_GDS3462_574_mouse_C3H10T1/2 fibroblast cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A8AZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K14780713 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.23037 HCC1395 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K94697940 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.62887 metabolic process GO Biological Process Annotations 2015 1.0 null GTEx Colon 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures -1.0 -5.81863 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A8NY-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3591-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null Psoas_Muscle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.11468 GSE202434,GSE202438_3_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Alzheimer's Disease_CNS - Brain - Hippocampus (MMHCC)_GSE1297 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.10215 Superior colliculus, zonal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11175 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25142 YY1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HELA Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.1689 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221327_6_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null morantel-1840 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K21254338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20858 EGR1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.59633 GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19205 GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32227 GTEX-PVOW-0426-SM-2XCF8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981613 GTEX-SIU8-0826-SM-2XCDQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97835 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QB-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K16436767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27862 HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11227 SIX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Elongator holoenzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.045 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970122 SIN3A ENCODE Transcription Factor Targets 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K13389917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5863 Arsenic CTD Gene-Chemical Interactions 1.0 null oxaliplatin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23444 1040_C1ORF131_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.805823 GTEX-VUSG-2226-SM-4KKZO GTEx Tissue Sample Gene Expression Profiles 1.0 0.862932 Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.58563 ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38650960 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0075 SKMEL2 BioGPS Cell Line Gene Expression Profiles 1.0 1.63585 lateral part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27668 r4 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09252 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE229309,GSE229314_4_v_1_elavl1_human RummaGEO Gene Perturbation Signatures -1.0 null Medial geniculate complex, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04568 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933678 HCC2157 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 ZNF384 ENCODE Transcription Factor Targets 1.0 null GW311616 DeepCoverMOA Drug Mechanisms of Action 1.0 0.18 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.844114 deferasirox_homo sapiens_gpl570_gds3558 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HEC108 CCLE Cell Line Gene Expression Profiles -1.0 -2.20027 Vascular disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.717 CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.44124 TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ESRRG_Deficiency_GDS2811_637_mouse_Fetal heart - Heterozygous null mutant GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4865-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.908698 BRD-K66383189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73408 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.717 Brain Lower Grade Glioma_LGG_TCGA-HT-A616-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPA-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-S95S-0726-SM-4B64H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.973703 gemcitabine_homo sapiens_gpl96_gse6914 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157383_6_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null LHX8_Deficiency_GDS3254_600_mouse_Newborn ovaries GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1273 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.51816 GSE148066,GSE157787_0_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.018 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles 1.0 0.897105 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.38893 AD-28-GJ71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.271951 NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KP4 CCLE Cell Line Gene CNV Profiles 1.0 1.53815 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2BK120ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2970-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NI-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles 1.0 3.97009 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17226 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 2.39858 GSE103068_0_v_1_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null HCT-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20095 BRD-K27356753 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06029 striatal part of olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3026 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null spinal trigeminal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.4956 intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.18886 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFJO-0002-SM-3P61X GTEx Tissue Sample Gene Expression Profiles 1.0 1.34328 RH30 CCLE Cell Line Gene CNV Profiles -1.0 -2.26534 yeast GeneRIF Biological Term Annotations 1.0 null doxorubicin-4610 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07671 GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K01734019 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18386 buflomedil-1338 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CREB1 ChEA Transcription Factor Targets 1.0 null GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.74587 GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.67809 Oligospermia CTD Gene-Disease Associations 1.0 1.03864 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 2.169 EGR1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61733751 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91154 GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25011 r6 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28026 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.908698 Nolatrexed DeepCoverMOA Drug Mechanisms of Action -1.0 -0.64 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.955087 HCC1395 DepMap CRISPR Gene Dependency 1.0 2.32518 carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060727 ChIP_SOX2_19030024 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TAF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.39388 ATF3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.35542 ATF2 ENCODE Transcription Factor Targets 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -0.844005 GSE142210_4_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE48812_7_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE186810,GSE186813_2_v_5_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.92513 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.05498 AC-47-YZ27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.333177 9420_TUBB_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.13051 MM160113 DepMap CRISPR Gene Dependency 1.0 2.26371 IC-05-AW29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217147 SRF_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4652-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24005 BRD-K15939043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30176 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-549 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K52123140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86802 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SJ-01A-12R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X3Y1-0726-SM-3P5YU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869263 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.988424 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null striatum_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.13751 deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.54083 EVSAT DepMap CRISPR Gene Dependency 1.0 7.14333 superficial stratum of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27309 plicamycin_homo sapiens_gpl570_gse25127 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K02882086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47063 EB-66-IH06_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218842 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r7 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13552 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tachycardia_Myocardial tissue_GSE7999 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.07747 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A2OS-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06766 SKMEL5 BioGPS Cell Line Gene Expression Profiles 1.0 1.64375 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CSTB_KO_GDS5090_199_mouse_Cerebellum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null embryoday10.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.886336 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null Plant candle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.573 BRD-K84478344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.15338 MEF2A_KD_GDS4759_340_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09735 SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.82427 Benzbromarone DeepCoverMOA Drug Mechanisms of Action 1.0 0.35 GTEX-QEL4-1326-SM-447AD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.919036 GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G-1 DeepCoverMOA Drug Mechanisms of Action -1.0 -1.42 BRD-K11004561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71463 SB-89-QK94_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.281804 HEC265 CCLE Cell Line Gene Expression Profiles -1.0 -1.90156 BRD-K07274638 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50605 Brain Lower Grade Glioma_LGG_TCGA-DB-5277-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1 ChEA Transcription Factor Targets 1.0 null CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.971505 GABPA ENCODE Transcription Factor Targets 1.0 null HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.45635 k562 HPA Cell Line Gene Expression Profiles 1.0 0.851331 BRD-K98598055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01138 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LY2584702 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.68 PANC-08-13 COSMIC Cell Line Gene CNV Profiles 1.0 2.16947 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hypothalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.287 BRD-K81976047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01199 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4711-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 BRD-K77775127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20661 GSE199543,GSE239447_0_v_4_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-Q2AG-0826-SM-2HMKF GTEx Tissue Sample Gene Expression Profiles 1.0 1.1362 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.862765 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 8599_SUPT6H_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.520816 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.831829 YY1-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K57969360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47232 BRD-K09378334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42804 KLF5-20875108-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null AD-51-FB60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20893 nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE201309_4_v_7_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null organonitrogen compound biosynthetic process GO Biological Process Annotations 2023 1.0 null H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RAD21_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P78B-0526-SM-2I5F7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37319 GTEX-PX3G-0826-SM-48TZS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.932884 CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.939896 BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.494537 diflunisal-1908 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.51618 GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.897602 BRD-K15202679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50853 Necrosis CTD Gene-Disease Associations 1.0 1.31297 GTEX-NPJ7-0011-R4a-SM-2I3GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852518 GSE183101_0_v_1_hvcn1_human RummaGEO Gene Perturbation Signatures -1.0 null RNA methylation GO Biological Process Annotations 2023 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03326 GTEX-XOTO-2126-SM-4B64U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849176 MYBL2-22936984-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RNA N6-methyladenosine methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.137 binding GO Molecular Function Annotations 2015 1.0 null external part of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67206 OE-31-YC41_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.340668 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81691 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.48744 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE235390_4_v_2_lurbinectedin_human RummaGEO Drug Perturbation Signatures -1.0 null BC-61-BE07_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266957 Trypanosomoid form TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.033 H3K27ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE183327,GSE183328_1_v_0_ddit3_human RummaGEO Gene Perturbation Signatures 1.0 null EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.885333 Lung squamous cell carcinoma_LUSC_TCGA-90-7769-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X261-0011-R10B-SM-4E3JT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02318 CDK10_knockdown_116_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.77586 hsa-miR-548f TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE127790_13_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03126 rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.26443 BRD-K72314068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31364 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null BRD-K95860374 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04267 mitoxantrone-6755 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HGC-27 GDSC Cell Line Gene Expression Profiles 1.0 1.70184 GSE195513_0_v_3_cpeb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07653 Prostate adenocarcinoma_PRAD_TCGA-HC-A8CY-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27656 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE242290_1_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1500 CCLE Cell Line Gene Expression Profiles 1.0 1.55246 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TW-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.41446 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06282 Lateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03786 GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27394 H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Mouselcells TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.576 Declive (VI), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53127 OB outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07569 dorsolateral prefrontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.963421 NCIH2081 CCLE Cell Line Gene CNV Profiles -1.0 -1.50237 AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA ChEA Transcription Factor Targets 2022 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OB-20-LP90_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.355211 BRD-K78647367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00963 YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22383 SW-48 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.948 YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-2 GDSC Cell Line Gene Expression Profiles 1.0 1.69506 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX2-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null AE-42-HT01_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206872 GSE246195,GSE246305_1_v_0_sin3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.949758 LB771-HNC COSMIC Cell Line Gene Mutation Profiles 1.0 null SRF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193993_5_v_6_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15147 prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30601 Inflammation CTD Gene-Disease Associations 1.0 1.23616 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.54476 SARS-CoV_36Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.44792 hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.869701 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.69067 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053786 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RA-49-ZB08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252819 BRD-K35799753 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18908 GTEX-P4QS-2626-SM-2I3EV GTEx Tissue Sample Gene Expression Profiles 1.0 1.63376 KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.41092 posteroventral (inferior) parietal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.31909 G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.29207 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4228-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FMR1_KD_GDS4759_333_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null YY1-33199912-293T-HUMAN-KIDNEYEMBRYO ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7015-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles 1.0 1.54523 RAD21_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.930992 HB-24-GP45_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.477587 Pi Mi complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.139 NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22704 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.944896 Hypomyelinating leukodystrophy 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.273 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17666 GTEX-T6MN-1226-SM-3NMA5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960494 Uterine Carcinosarcoma_UCS_TCGA-NF-A5CP-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREM ChEA Transcription Factor Targets 1.0 null 15902281-TableS1a GeneSigDB Published Gene Signatures 1.0 null breast cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.108101 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M5-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXM1 ENCODE Transcription Factor Targets 1.0 null GSE130437_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE111247_0_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.927739 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.70419 GSE165122_2_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66939340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83431 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.978031 dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62714 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.92519 GTEx Esophagus 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures -1.0 -7.1945 POLR2A_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RXRA-24833708-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K38932508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34523 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02763 GTEX-NPJ8-0011-R7a-SM-2HMJV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.937945 CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.895729 Lung squamous cell carcinoma_LUSC_TCGA-66-2758-01A-02R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.88804 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45017 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18797 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.901671 GTEX-QV44-0826-SM-2S1RG GTEx Tissue Sample Gene Expression Profiles 1.0 1.91851 glycosyl compound biosynthetic process GO Biological Process Annotations 2023 1.0 null GSE186460_3_v_6_baricitinib_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-4762-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.1054 BHT-101 GDSC Cell Line Gene Expression Profiles 1.0 1.95916 GSE111035,GSE111040_10_v_12_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.904081 glipizide-2008 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null SOX2-20726797-SW620-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ChIP_YY1_21170310 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE153137,GSE153140_2_v_1_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.83396 BRD-K04454173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56814 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T8EM-0826-SM-4DM76 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975578 AU565 CCLE Cell Line Gene CNV Profiles 1.0 1.64204 GSE103068_0_v_4_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K12384030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00425 AC-28-RT00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.464572 FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null BRD-K72183943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57416 supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.837693 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3653 Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.21408 Whipple's Disease_macrophage_GSE16180 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.73534 GTEX-SUCS-0226-SM-32PLQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.35486 intermediate stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07668 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.65277 C3A CCLE Cell Line Gene Expression Profiles -1.0 -1.75615 GTEX-RVPV-0526-SM-47JYL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09663 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K49307935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24549 VCaP cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.932 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050833 folic acid_homo sapiens_gpl2700_gds3656 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K75426080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49131 BRD-K19526797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2912 GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870204 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5458-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neoplasms CTD Gene-Disease Associations 1.0 1.03382 ETS1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Spleen GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.2205 SP1 ENCODE Transcription Factor Targets 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles 1.0 1.17549 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.64251 postcentral gyrus, right, inferior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.96568 BRD-K05221385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94612 GTEX-NL4W-0011-R9a-SM-2I3G1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05729 Accessory olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26074 GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SIX5 ENCODE Transcription Factor Targets 1.0 null inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.48599 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23854 hsa-miR-3148 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE224599_0_v_1_tfcp2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.7441 dorsal subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22656 GSE205540_2_v_3_phloridzin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE112760,GSE112767_1_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null ASH2L ChEA Transcription Factor Targets 1.0 null GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09159 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23598860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37516 BRD-K79887921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04511 tRNA methylation GO Biological Process Annotations 2023 1.0 null POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null VB-27-PZ25_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.383382 A-CA-04-2009(H1N1)_12Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.62204 BRD-K08576275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35311 Choanomastigote TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.197 lasalocid-4985 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE111247_0_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K10528627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.55335 Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67559 H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HGC27 CCLE Cell Line Gene CNV Profiles 1.0 2.94447 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dorsal column nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09864 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K68328788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.09844 anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.8797 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057289 BRD-K01067435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77714 inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35806 Perturb_12050_KD_Mtss1_SRP185976 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07841 GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40908 HCC1937 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.899523 Lung squamous cell carcinoma_LUSC_TCGA-77-8143-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32432 ZBTB33_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19204204-SupplementaryTable5 GeneSigDB Published Gene Signatures 1.0 null Urothelial carcinoma_Urothelium_GSE3167 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.49741 posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23747 FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3-24758297-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE130437_2_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 1.17155 NB4 CCLE Cell Line Gene CNV Profiles -1.0 -1.73011 BRD-K75085700 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15258 RD cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.697 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null posttranscriptional GeneRIF Biological Term Annotations 1.0 null HCC1419 CCLE Cell Line Gene Expression Profiles 1.0 2.48728 intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 FC-64-QJ96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229927 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.20457 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z6-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QCQG-0008-SM-48U2G GTEx Tissue Sample Gene Expression Profiles 1.0 0.893945 BRD-K03659510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.73926 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Minor Salivary Gland GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.36058 GSE189609_1_v_0_hax1_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K24950073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43357 EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null ventral subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06265 magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17011 GTEX-XQ3S-0008-SM-4GIDZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.902445 mefexamide-1438 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K04785821 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21471 JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.84038 GTEX-S341-1526-SM-4AD6K GTEx Tissue Sample Gene Expression Profiles 1.0 0.962231 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4217-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Fog2_KO_GDS3659_152_mouse_adult heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135350_3_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null ERG ChEA Transcription Factor Targets 1.0 null Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.2 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.866109 central nervous system disease GWASdb SNP-Disease Associations 1.0 0.091319 BRD-K91241684 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21323 BRD-K07276273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.68799 Lobule III, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00313 GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14778 r5 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46334 SIX5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.975127 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.893554 GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.50885 GTEX-WYJK-0005-SM-3NMA1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42369 BRD-K21420222 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06881 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37962 GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 0.923331 GSE213588_10_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW48 GDSC Cell Line Gene Expression Profiles -1.0 -1.64426 BRD-K39422601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03328 ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.829281 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles 1.0 2.15979 BRD-K04771555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.34007 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K18ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Sin3-type complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.714 FOXA1-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HE-80-BQ08_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.35891 BRD-K20836550 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54814 Lateral reticular nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00625 BRD-K25658788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04688 GSE184399_0_v_2_cnot1_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A94420133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16137 1441_CDK7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.754064 IU1 DeepCoverMOA Drug Mechanisms of Action 1.0 0.22 Cognition Disorders CTD Gene-Disease Associations 1.0 1.12668 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.70266 NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1659 BRD-K47858507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61409