association	dataset	threshold value	standardized value
harmaline-2805	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SB-203580-6894	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gain	GeneRIF Biological Term Annotations	1.0	null
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
total	GeneRIF Biological Term Annotations	1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_DN-Gene_name_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
muscle	GeneRIF Biological Term Annotations	1.0	null
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
TGFB_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.280717
K562_A-366_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192112
GSTA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646118
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149359_2_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
L-540	GDSC Cell Line Gene Expression Profiles	-1.0	-1.87206
GTEX-OHPL-0126-SM-2HMJ7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04804
BRD-K96037667_19-norethindrone_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Palmoplantar keratosis	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE229978_4_v_2_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06212
TCFCP2L1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal blood vessel physiology	MPO Gene-Phenotype Associations	1.0	null
BRD-K14399036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35822
CTV1DM	DepMap CRISPR Gene Dependency	1.0	4.66947
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054231
rpmi8226	HPA Cell Line Gene Expression Profiles	-1.0	-0.825084
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79085
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
calcium channel activity	GO Molecular Function Annotations 2023	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TM-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.284
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.622
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938822
BRD-K15879529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08463
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.732183
GTEX-U3ZH-0926-SM-4DXU4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55344
Sarcolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.824
BRD-K11687039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2935
Perturb_4305_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.66368
metacycline-4062	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RN64-0626-SM-2TC5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11245
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.19509
BRD-K99482176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02001
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
syndrome	GeneRIF Biological Term Annotations	1.0	null
GTEX-VJYA-2026-SM-4KL1K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44994
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892116
GSE153341_2_v_3_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
purkinje	GeneRIF Biological Term Annotations	1.0	null
LS123	CCLE Cell Line Gene CNV Profiles	1.0	1.81455
basomedial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.943475
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.859002
Perturb_1771_OE_Erg_SRP239807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65074
SOSS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
BRD-K46119789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.146
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.9036
pip2	GeneRIF Biological Term Annotations	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.62209
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29306
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
tanespimycin-1650	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899705
perphenazine-1540	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K26300881_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K23027438_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pulmonary artery endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HGC27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33241
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09148
bmmc cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.382508
GSE94849_1_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cation channel complex	GO Cellular Component Annotations 2025	1.0	null
Abdominal Pain	DisGeNET Gene-Phenotype Associations	1.0	null
ADENOSINE	DGIdb Drug Targets 2026	1.0	0.283059
smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.08943
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	216.932
centromedian nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15096
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.82724
Reticulum trabeculare	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.838
Rectum adenocarcinoma_READ_TCGA-AF-2691-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ITK_defectivemutant_125_GSE28200	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.32742
progressive familial heart block, type ib	OMIM Gene-Disease Associations	1.0	null
adiphenine-1831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K31342827_GF-109203X_SNUC4_6.0_h_12.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pkc	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44329
GSE195568_6_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.5808
reduce	GeneRIF Biological Term Annotations	1.0	null
BRD-A56359832_zileuton_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Keratoderma	DisGeNET Gene-Disease Associations	1.0	null
shortened pr interval	HPO Gene-Disease Associations	1.0	null
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Heart disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Aorta smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.487
pepstatin-4206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964081
cefalexin-4654	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.306
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14111
CDKN2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544109
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWCY-1026-SM-48TD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57578
Fatty Liver	CTD Gene-Disease Associations	1.0	1.66878
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02595
SNU840	Achilles Cell Line Gene Essentiality Profiles	1.0	1.95053
JUN	ENCODE Transcription Factor Targets	1.0	null
PMC4551213__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32321
pirenzepine-2071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5883-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
PDE4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00458919
RMUGS	CCLE Cell Line Gene CNV Profiles	1.0	1.97721
calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.555145
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.1273
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K80786583_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69132276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25175
SRY	ChEA Transcription Factor Targets	1.0	null
NCI-H647	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.01023
BIRC7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599438
Perturb_12773_KO_Bin1_SRP201679	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.43634
BRD-K76318449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07694
Atrial heart septal defect	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
GTEX-T2YK-2226-SM-32QPT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864043
MAP3K7_knockdown_37_GDS5023	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.64751
RBM38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55635
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19331
CRCGN016_MCF10A.TP53.M_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56276
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848839
BRD-K60932973_R(+)-6-BROMO-APB_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.995
Arterial blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.313
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of signaling	GO Biological Process Annotations 2015	1.0	null
WEE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516687
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A19037878_trichostatin A_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SUM159PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.841872
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Y-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIN87	Achilles Cell Line Gene Essentiality Profiles	1.0	1.51544
CRCGN008_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21625
NOMO1	DepMap CRISPR Gene Dependency	1.0	2.20901
Brain Lower Grade Glioma_LGG_TCGA-DB-A75P-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adenoma	CTD Gene-Disease Associations	1.0	1.07376
Bundle-Branch Block	DisGeNET Gene-Disease Associations	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14321
Endometrial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5583
ion binding	GO Molecular Function Annotations 2015	1.0	null
promazine-6028	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ECC12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PUS10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665396
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
inner hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.683103
Tongue epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.888
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
streptomycin-5837	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4677-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Endometrial carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18482
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090766
PAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59238
cinoxacin-5783	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67578145_GDC-0879_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.941071
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2C_MEF2C	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86192746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11008
OAW42	Achilles Cell Line Gene Essentiality Profiles	1.0	2.04401
GSE123022,GSE123030_8_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Arrhythmogenic right ventricular dysplasia 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
BRD-K12867552_THM-I-94_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MEL270	DepMap CRISPR Gene Dependency	1.0	6.81198
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
Brugada syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
External carotid artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31247
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23456
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02445
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
helveticoside-4327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229436
Ventricular Arrhythmia	DisGeNET Gene-Disease Associations	1.0	null
scopolamine-4803	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC2185	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.0343
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04883
desensitization	GeneRIF Biological Term Annotations	1.0	null
BRD-K81385845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03961
BRD-K49328571_dasatinib_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68118416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2982
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rosiglitazone-1071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.28349
BRD-K12040459_AT7867_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gating	GeneRIF Biological Term Annotations	1.0	null
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
interacts	GeneRIF Biological Term Annotations	1.0	null
florfenicol-5300	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BEN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K30853940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85942
NCIH1623	CCLE Cell Line Gene CNV Profiles	1.0	1.58269
KDM4A	ENCODE Transcription Factor Targets	1.0	null
metolazone-5392	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_G007-LK_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0104009
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2706-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08799216_pelitinib_MDAMB231_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DROSHA	ChEA Transcription Factor Targets	1.0	null
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell periphery	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.726599
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
6861_PSMC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14249
9461_TXN_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540486
cochlear duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24486
CEACAM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00669042
Brachyolmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
Myocarditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
EMP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622382
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880595
BRD-K94540403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.7337
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33898
WBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36262
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.832525
BRD-K23361743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72902
BRD-K71243741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.236
BRD-K64797043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15102
Heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.59
ventral lateral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01408
metanephrine-5334	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11813851-12672_2025_1910_MOESM3_ESM.xlsx-Sheet1-Table_S2_Results_of_two-sample_drug-target_MR_analyses_for_pancreatic_cancer_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17146
GSE188814,GSE188854_0_v_1_wtap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72636697_QL-X-138_SKBR3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Communicating hydrocephalus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.794
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35422
ZNF263	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52362
Perturb_12297_OE_TMEM33_SRP322205	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24496049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65057
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WHPG-2626-SM-3NMBR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984816
mast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315498
regulation of T cell cytokine production	GO Biological Process Annotations 2025	1.0	null
kaempferol-5839	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24599650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28679
regulation of heart contraction	GO Biological Process Annotations 2015	1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154940_1_v_0_nbdy_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
17192395-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
monoatomic cation transmembrane transport	GO Biological Process Annotations 2025	1.0	null
BRD-K17659275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86488
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465217
Prostatic Intraepithelial Neoplasias	DisGeNET Gene-Disease Associations	1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.7274
Lung adenocarcinoma_LUAD_TCGA-97-7554-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCZ1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68438
RPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85321
GTEX-XQ8I-2126-SM-4BOOM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0563
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861888
LNCaP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.389
SK-N-AS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
force	GeneRIF Biological Term Annotations	1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78441
Bone marrow cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.12
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.935859
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981846
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219047
NDUFB10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570747
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45P-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cation	GeneRIF Biological Term Annotations	1.0	null
GTEX-X4XY-0826-SM-4E3JM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963465
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36549
Stria vascularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.908
Sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.787
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
POLR2A	ENCODE Transcription Factor Targets	1.0	null
18081427-TableS8	GeneSigDB Published Gene Signatures	1.0	null
Plasma membrane	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.221938
GTEX-VUSG-2526-SM-4KL1V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990941
RDES	CCLE Cell Line Gene Expression Profiles	1.0	1.85611
regulation of cytokine production	GO Biological Process Annotations 2015	1.0	null
GTEX-PLZ6-1126-SM-3P5ZR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53885
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30455
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	1.0	3.87753
Channelopathies	DisGeNET Gene-Disease Associations	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980373
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ENPP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569235
GSE101546_2_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.81984
Aortic smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
Perturb_11468_KO_AURKA_SRP298688	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.83492
CLNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542855
6857_PSMC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09873
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-2.39936
BRD-K57748937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35451
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Calcium	CTD Gene-Chemical Interactions	1.0	null
BRD-A37780065_TRIAMCINOLONE_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_1167_KD_ETV6_ERP128093	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-U3ZM-0926-SM-4DXSW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40873
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7912581__F8	PFOCR Pathway Figure Associations 2024	1.0	null
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_11_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal immune cell physiology	MPO Gene-Phenotype Associations	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.22069
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X5EB-1726-SM-4E3J7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949444
GTEX-XBED-1526-SM-4AT5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73128
calcium-calmodulin-dependent-protein-kinases	Phosphosite Textmining Biological Term Annotations	1.0	null
SKP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598157
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GPKOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08755
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.057173
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU1_STOMACH	CCLE Cell Line Proteomics	1.0	3.8819
Perturb_11107_KO_Cpt2_SRP303636	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
metal ion binding	GO Molecular Function Annotations 2025	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38505
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210124
upstream	GeneRIF Biological Term Annotations	1.0	null
BRD-K69077676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26527
Thrombosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colon	HPA Tissue Gene Expression Profiles	1.0	0.832341
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02347
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
metal ion transport	GO Biological Process Annotations 2025	1.0	null
7723_SDHAF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.610892
Prestwick-682-4984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37079
RAJI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
bendroflumethiazide-3934	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
increased inflammatory response	MPO Gene-Phenotype Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-93-7348-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
APOBEC3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00761325
Prestwick-920-6497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tropicamide-4744	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8350-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Axon initial segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.16
6793_PRPF31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516432
BRD-K77023196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36915
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52639
TRIM46	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582882
AXIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00446529
HS294T	DepMap CRISPR Gene Dependency	1.0	2.91255
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.767029
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90527476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62552
Endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.034
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02023
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.925248
GSE128730_3_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.903823
being	GeneRIF Biological Term Annotations	1.0	null
Muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
regulation of ventricular cardiac muscle cell action potential	GO Biological Process Annotations 2023	1.0	null
1583_CHMP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50547
Sick sinus syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.201
BRD-K90205159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37055
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
T-tubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.55
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
norfloxacin-2090	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084357
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of adaptive immune response	GO Biological Process Annotations 2015	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.0736
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-TMMY-1626-SM-4DXTY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956101
PMC4312948__F7	PFOCR Pathway Figure Associations 2023	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.519
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51211
RCOR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K44432556_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.839046
GSE233679_5_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Daphnetin_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162541
necessary	GeneRIF Biological Term Annotations	1.0	null
monocrotaline-2749	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063304
cation transport	GO Biological Process Annotations 2015	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22854
calcium ion transport	GO Biological Process Annotations 2025	1.0	null
GSE220600_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01877528_TL_HRAS26_SNUC4_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
U87MG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.658
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SKES1	CCLE Cell Line Gene Expression Profiles	1.0	1.84583
corpus cavernosum penis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.277549
BRD-K93248080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05609
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Long QT syndrome 14	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
Sudden cardiac death	ClinVar Gene-Phenotype Associations 2025	1.0	null
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56531
hippocampus (hippocampal formation)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.956501
voltagedependent	GeneRIF Biological Term Annotations	1.0	null
A-Vietnam-1203-2004(H5N1)_12Hour_21865398_GSE28166	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.30568
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10381
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45146
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221763
9489_UBAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.593991
Edema	CTD Gene-Disease Associations	1.0	1.1437
Carotid body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
sulfamonomethoxine-3484	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.557
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
Lung adenocarcinoma_LUAD_TCGA-97-7547-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829284
7950_SLBP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.611145
1544_CHAF1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52079
PMC10020087-41388_2023_2602_MOESM3_ESM.xlsx-MDAMB231_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
AMER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01568
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16715
PML_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-1326-SM-4LVMS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41399
pkc-dependent	Phosphosite Textmining Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HF-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9555
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic alpha cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.248
triamcinolone-5835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059858
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99660943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50983
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.782
VM-CUB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
rectum_8d	HPA Tissue Sample Gene Expression Profiles	1.0	1.29285
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
taste bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.572418
loracarbef-3532	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HELZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23186
GSE199255,GSE199356_3_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87
PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.988391
GTEX-XPVG-2626-SM-4B669	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88604
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06351
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sodium channel activity	GO Molecular Function Annotations 2023	1.0	null
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04166
proxyphylline-5993	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X2-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FD-74-XT10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279454
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
intracellular	GeneRIF Biological Term Annotations	1.0	null
BRD-K92073408_Norethindrone_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SARS-CoV MA15_Day7-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.9058
BRD-K05001008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20884
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
Perturb_16424_OE_AUF1_SRP224925	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SNU869	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20312
Pronephros	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.591
GSK3B_KD_GDS4305_179_human_HL-60 acute myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SPPL2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586152
HEC-108	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.98
locomotion	GO Biological Process Annotations 2015	1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49526
BRD-K35517098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51442
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.901046
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6664
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71108
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K29415052_NVP-BGT226_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23549
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74148702_curcumin_VCAP_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
epidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.971017
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-53-7624-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59816
Neurotransmitter receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.384
regulator	GeneRIF Biological Term Annotations	1.0	null
GTEX-SUCS-1926-SM-32PM3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15588
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285697
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.875057
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
17192395-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52342
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GM-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.873237
abnormal leukocyte morphology	MPO Gene-Phenotype Associations	1.0	null
budesonide-2866	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Dyspnea	DisGeNET Gene-Phenotype Associations	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2357
PHA-00816795-7076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4988
control	GeneRIF Biological Term Annotations	1.0	null
phosphorylation	GeneRIF Biological Term Annotations	1.0	null
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07653
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.7879
Perivascular astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.355
LNCaP-Clone-FGC	GDSC Cell Line Gene Expression Profiles	1.0	1.65539
BRD-K10196668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24754
dirithromycin-7446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of bone mineralization	GO Biological Process Annotations 2025	1.0	null
basal nucleus of Meynert	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.946952
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920802
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GTEX-P4PQ-0126-SM-2S1NM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910691
PMC11551338-pnas.2411189121.sd01.xlsx-FXR-Unnamed_0_NR1H4	Rummagene Transcription Factor Associations 2026	1.0	null
oxaprozin-971	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
resting	GeneRIF Biological Term Annotations	1.0	null
BRD-K07614312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94586
Spiral organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.385
PMC9911396-41467_2023_36178_MOESM11_ESM.xlsx-Sheet1-Genes_in_10kb_vicinity_of_ZBTB12_ChIP-seq_peaks_hic_ZBTB12	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thyroid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.18772
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18023
KNTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27656
GTEX-OXRN-0126-SM-48TDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863087
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68331
CSNK1A1	PhosphoSitePlus Substrates of Kinases	1.0	null
cases	GeneRIF Biological Term Annotations	1.0	null
EWSR1_KD_GDS4962_465_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968492
haloperidol-1203	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.872
Muscular coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
PRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614767
Impaired Cognition	DisGeNET Gene-Disease Associations	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12536
Choroid plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.202
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860904
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25995
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.13313
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10350077-media-7.xlsx-microglia_proteomics_LPS-Gene_Symbol_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
heliotrine-6035	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.00103
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04505
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A07029265_IPRATROPIUM BROMIDE_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BEST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639226
positive regulation of cell proliferation	GO Biological Process Annotations 2015	1.0	null
HCT15	BioGPS Cell Line Gene Expression Profiles	1.0	1.15335
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
NCI-H835	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DROSHA-22980978-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE152441,GSE152442_0_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11795542_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A26711594_NICARDIPINE HYDROCHLORIDE_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34082
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.967889
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07116
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MOLT-16	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49649
trpm4b	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LIPF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520132
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182835,GSE182836_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91290917_Amodiaquin dihydrochloride dihydrate_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCRTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593048
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ventral posterior lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32958
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47105
GTEX-PWOO-1326-SM-48TCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39519
SNU668	DepMap CRISPR Gene Dependency	1.0	3.69784
cell migration	GO Biological Process Annotations 2015	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-1426-SM-3NM9L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60387
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-UJMC-1326-SM-4IHLS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.76019
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42651
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K85588347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01811
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00973
BRD-K75806288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16421
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48459
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-80-5611-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO201	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59394
AMIGO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582144
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
f11	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.957
8552_STX18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.59978
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
hematopoietic system phenotype	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE231648_0_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-5784-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20696416_NVP-AEW541_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4551213__F6	PFOCR Pathway Figure Associations 2023	1.0	null
SAMD4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00768131
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
aorta smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233162
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ADENOSINE MONOPHOSPHATE	DGIdb Drug Targets 2026	1.0	1.55682
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPP1R12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.69088
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AJUBA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528316
GTEX-TKQ2-1326-SM-4DXT9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92871
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
t24/83	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
GTEX-T5JC-2126-SM-32PMO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919305
CRCGN012_HEPG2_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22532
Integrator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.259
Sinoatrial node disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.205
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01465
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05327
Integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.469
aberrant	GeneRIF Biological Term Annotations	1.0	null
GTEX-XOTO-2826-SM-4B65I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48642
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.187113
BRD-K95709431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02856
PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP2_cds_exp_down-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
MMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10443
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.258
EZH2_DEPLETION_GDS2445_117_human_embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A28970875_PUROMYCIN HYDROCHLORIDE_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8431-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20881
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC5794192-ppat.1006868.s001.xlsx-S1B_Table-S1B_Table_Differentially_expressed_genes_between_IRF8-sg2_and_NC_cell_lines_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205163,GSE205164_2_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95666495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52765
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892116
HTC-C3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.28841
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.37619
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3298
Large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
sodium ion import across plasma membrane	GO Biological Process Annotations 2023	1.0	null
BRD-K59484021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27695
CA2+	DGIdb Drug Targets 2026	1.0	0.0759426
17597811-SuppTable6	GeneSigDB Published Gene Signatures	1.0	null
BRD-K88573743_A443654_HS578T_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
t66-lung_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	6.06716
sulfabenzamide-4979	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9293
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14853
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Periciliary membrane compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.905
PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Human_RORC_DC_signature_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52130884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41175
TEN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35478
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0189
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.418019
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.894394
3308_GBF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.850243
multicellular organismal signaling	GO Biological Process Annotations 2015	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039181
thiostrepton-2823	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.64743
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.092
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255091
9065_DMAC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.40058
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.22469
PIP2	DGIdb Drug Targets 2026	1.0	0.389206
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33283
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
BRD-K39419290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60786
positive regulation of cell population proliferation	GO Biological Process Annotations 2025	1.0	null
Myosin filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.748
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.12564
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.02591
SFXN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635253
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JK-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908659
GTEX-PLZ6-0926-SM-3P5ZQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9817
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DNAJB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13052
metitepine-5413	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2312
Sigmoid_Colon	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.02447
Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15907840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45655
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526654
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.45289
GTEX-P78B-1826-SM-3P5YX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3042
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
increased susceptibility to type I hypersensitivity reaction	MGI Mouse Phenotype Associations 2023	1.0	null
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06623
CCK-81	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.42491
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.13719
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.32226
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K94132559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56881
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65555
Sarcoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.236
NKM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
protein modification by small protein conjugation	GO Biological Process Annotations 2023	1.0	null
positive regulation of membrane depolarization	GO Biological Process Annotations 2025	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K19687926_lapatinib_SKBR3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NSF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00374268
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.714831
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.64781
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0859
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.12084
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.962742
HIPK2_defectivemutant_17_GDS1793	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.5392
NCI-H2795	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.16268
6858_PSMC2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.807774
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	205.291
BRD-K51411441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79275
BRD-K48922193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.90712
Influenza_B Cell Lymphocyte_GSE3203	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.95622
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stria vascularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.638809
urinary bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.609332
Syncope	DisGeNET Gene-Phenotype Associations	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03625
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88758
CYB5R3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567936
BRD-K93874059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26575
CBX3	ENCODE Transcription Factor Targets	1.0	null
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WYVS-2126-SM-3NMA3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11378
basophilic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.420004
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.827571
Carotid artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.525
regulatory	GeneRIF Biological Term Annotations	1.0	null
CF-91-JY05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262329
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07619
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.27277
monoatomic cation transmembrane transport	GO Biological Process Annotations 2023	1.0	null
BRD-K97985992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48464
GTEX-XV7Q-2126-SM-4BRVX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49449
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01827
Perturb_7187_OE_CDH1_SRP279053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-WFG8-1826-SM-4LVM4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52217
BRD-K81418486_vorinostat_HT115_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
heart	GeneRIF Biological Term Annotations	1.0	null
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09086
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04024
6867_PSMD13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.558064
corpus cavernosum clitoridis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.293151
SLC38A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733802
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
regulation of tube size	GO Biological Process Annotations 2015	1.0	null
Cardiac Arrhythmia	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K45271289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68187
Large_Intestine-mature enterocyte	Tabula Sapiens Gene-Cell Associations	1.0	1.47918
BRD-K95712112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.078
Astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.093
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.09998
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39687
STOCK1N-28457-6906	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulated	GeneRIF Biological Term Annotations	1.0	null
protein tetramerization	GO Biological Process Annotations 2025	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CD-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
1788_COPZ1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533917
histamine	GeneRIF Biological Term Annotations	1.0	null
adenosine-triphosphate	Phosphosite Textmining Biological Term Annotations	1.0	null
ligand-gated calcium channel activity	GO Molecular Function Annotations 2023	1.0	null
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
rectum	HPA Tissue Protein Expression Profiles	1.0	1.48277
negative regulation of biomineral tissue development	GO Biological Process Annotations 2023	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vasculature	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.779
BRD-A55594068_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRKACB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505367
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-135a	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Hypoglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.734
Perturb_11153_KO_Kap1_SRP065215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.7245
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03711
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frequently	GeneRIF Biological Term Annotations	1.0	null
PIAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0444
membrane depolarization during cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
Endocardium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.361
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cycloserine-7134	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09032
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
N18TG2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19003
Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.257572
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.133351
Prestwick-1080-3796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Progressive Familial Heart Block	DisGeNET Gene-Disease Associations	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63487554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55852
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6689252__F6	PFOCR Pathway Figure Associations 2023	1.0	null
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
valproic acid-1222	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15924
9341_TSG101_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.792648
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43389698_BMS-387032_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K82164249_S1140_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.24966
GTEX-O5YT-1426-SM-3MJHC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40932
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.888972
BRD-K65875972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04018
AMP-PNP	DGIdb Drug Targets 2026	1.0	3.11365
GLRX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514946
single-organism transport	GO Biological Process Annotations 2015	1.0	null
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.977191
BRD-K73839552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30862
BRD-K56041932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56874
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HPAEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
5729_NOC2L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511933
Diffuse Large B-Cell Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
Trifascicular Block	DisGeNET Gene-Disease Associations	1.0	null
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049215
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.63743
extracellular	GeneRIF Biological Term Annotations	1.0	null
regulation of insulin secretion involved in cellular response to glucose stimulus	GO Biological Process Annotations 2023	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K22293608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30704
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.825906
hydralazine-2311	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896934
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19704
negative regulation of osteoblast differentiation	GO Biological Process Annotations 2023	1.0	null
Uterine cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.369
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
metal ion transport	GO Biological Process Annotations 2015	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.898332
CAL-72	COSMIC Cell Line Gene Mutation Profiles	1.0	null
channels	Phosphosite Textmining Biological Term Annotations	1.0	null
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.983376
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103309_2_v_0_ube3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62648
Peripheral nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.017
anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31839
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070483
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.17341
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
regulation of system process	GO Biological Process Annotations 2015	1.0	null
BRD-K31666794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03334
Lung squamous cell carcinoma_LUSC_TCGA-L3-A4E7-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GLRA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00568839
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Long QT syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
PTEN_DELETION_GDS2446_710_human_HCT116 colon cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ion transport domain	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-XUW1-1926-SM-4BOP1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26137
KIF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23205
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2046
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFIC_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89191
Prostate adenocarcinoma_PRAD_TCGA-G9-6499-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prolonged qt interval	HPO Gene-Disease Associations	1.0	null
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	48.7127
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69844
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61323504_sb 225002_MCF7_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Corpus epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
BRD-K67602895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30643
BRD-K59434830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10398
resulting	GeneRIF Biological Term Annotations	1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97067262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90965
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.623751
positive regulation of insulin secretion	GO Biological Process Annotations 2023	1.0	null
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95677
Endolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.333
BRD-K88384015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22495
BRD-K76701247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30995
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60659
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LPAR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566422
PMC9147752__F2	PFOCR Pathway Figure Associations 2024	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228894_0_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC11528209-cd-23-1212_supplementary_table_s7_suppst7.xlsx-A549_EML4_KD_DEGs-List_of_DEGs_of_EML4-knockdown_vs_control_A549_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Respiratory smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.191
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of immune system process	GO Biological Process Annotations 2015	1.0	null
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.404
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chronic pulmonary heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20177
SF172	CCLE Cell Line Gene CNV Profiles	1.0	1.6563
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.837502
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PU-01A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76810206_NICERGOLINE_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PM20D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607776
skbr3	HPA Cell Line Gene Expression Profiles	1.0	1.47568
GTEX-SNOS-1026-SM-4DM4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938039
muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.32373
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
integration	GeneRIF Biological Term Annotations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3881
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.853828
Intracranial arterial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
altizide-4491	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37668
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.8156
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RHEB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03117
MDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15956
Microvessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.604
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Superior vena cava	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60190533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8747
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03855
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863524
Insulinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.48
2367_DPY30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55057
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.545
Venous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
WNT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555869
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.702
BRD-K17894950_INDIRUBIN_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_vs_GFP_adj_pval_0_05-Gene_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8140-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sensory Perception	Reactome Pathways 2024	1.0	null
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
23132/87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44875
BRD-K22748970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63811
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30325
calcium-mediated signaling	GO Biological Process Annotations 2025	1.0	null
CBA	DGIdb Drug Targets 2026	1.0	3.11365
sulfathiazole-1463	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H357	DepMap CRISPR Gene Dependency	1.0	3.07895
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.207
BRD-K42061172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59343
BRD-K11267252_CH5424802_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32537
GPNMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511227
lateral group of nuclei, left, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34478
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70501
Vertigo	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-S95S-0826-SM-4B64N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826898
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYBS-1126-SM-3NMAM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892732
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064821
COX8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051077
Perturb_14701_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.53501
ticarcillin-5829	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K60547079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01245
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Testicular cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.191
PMC10807933-NIHMS1954791-supplement-4.xlsx-Bag6_KD_proteomics-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SNOS-0526-SM-4DM54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21916
dendritic cell chemotaxis	GO Biological Process Annotations 2025	1.0	null
GSE201309_5_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.72613
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sensory ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
Optic neuritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
ethisterone-3783	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19914
ACLY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595815
oxolinic acid-5094	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13516
CRCGN017_MCF10A.WT.HP_24H:F07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1361
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05588
podophyllotoxin-5841	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ChIP_KLF4_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
1839_CPSF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03519
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14383477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17153
Vascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.851
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.86171
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	575.076
BRD-K64646189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15956
5768_NPLOC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.10461
BRD-K70262646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87847
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36625
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6737
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12939_KO_UBE2T_SRP312031	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.1541
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sodium channel activity	GO Molecular Function Annotations 2025	1.0	null
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.113417
amphotericin B-5404	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DY-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extraction	GeneRIF Biological Term Annotations	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13756
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
xenopus	GeneRIF Biological Term Annotations	1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9911396-41467_2023_36178_MOESM11_ESM.xlsx-Sheet1-Genes_in_10kb_vicinity_of_ZBTB12_ChIP-seq_peaks_ZBTB12	Rummagene Transcription Factor Associations 2026	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.81694
Inner hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.719
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A18328003_GDC-0980_SKBR3_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CDIPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598306
CDC73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44935
BRD-K17140735_-666_AGS_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
MOLM13	Achilles Cell Line Gene Essentiality Profiles	1.0	1.49691
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE244940_0_v_1_edf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_3Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.71984
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
GSTZ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049468
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078504
valproic acid-5582	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
depolarization	GeneRIF Biological Term Annotations	1.0	null
Pulmonary artery endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0726-SM-4B659	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980652
Keratosis	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
H3K27me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Calcineurin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.507
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.01353
Seizures	CTD Gene-Disease Associations	1.0	1.28395
PHF8	ENCODE Transcription Factor Targets	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34188
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93675803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10369
neurosecretory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.300679
SNU886	CCLE Cell Line Gene CNV Profiles	1.0	1.50716
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75748
KARPAS299	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7844
Cortical collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.219
GTEX-NFK9-2026-SM-3LK5K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11089
9479_UBA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.778233
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.67289
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PL-21	COSMIC Cell Line Gene Mutation Profiles	1.0	null
sirolimus-5567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE86507,GSE86509_4_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.593
BRD-K28565184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94707
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5467-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tribenoside-3507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JHH-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31354
transient	GeneRIF Biological Term Annotations	1.0	null
BRD-A52650764_Ingenol 3, 20-dibenzoate_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CMAH_KO_GDS4770_420_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873999
increase	GeneRIF Biological Term Annotations	1.0	null
BRD-K79523827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24217
ERMAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00903009
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00807
BRD-A18328003_GDC-0980_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
sulfabenzamide-2814	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SPATA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13411
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4132_OE_PS2APP_SRP092532	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.39497
regulation of cardiac muscle cell action potential	GO Biological Process Annotations 2023	1.0	null
Vascular smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.916
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MV411	Achilles Cell Line Gene Essentiality Profiles	1.0	1.37906
16109776-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BW 723C86	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
L-type voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.299
Progression Of Prostate Cancer	DisGeNET Gene-Disease Associations	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.633
SF539	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5162
fusiform gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.878434
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.04201
Adrenocortical carcinoma_ACC_TCGA-OR-A5LS-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90553655_Testosterone propionate_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Andersen-Tawil syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
PDE4D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00835727
Perturb_1698_KO_Kmt2c_SRP283007	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.46018
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTEN_DELETION_GDS2446_59_human_HCT116 colon cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	2.81239
ioxaglic acid-7470	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Olfactory receptor neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.049
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
capillary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.491009
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hESC Derived CD184+ Endoderm Cultured Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.977841
F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.23184
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.84446
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218098,GSE218099_1_v_0_tcf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
south	GeneRIF Biological Term Annotations	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A53463743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0669
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MT-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU601	CCLE Cell Line Gene CNV Profiles	1.0	2.07973
BRD-K39223685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1653
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Perturb_1176_KD_RUNX1_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Memory Disorders	CTD Gene-Disease Associations	1.0	1.40925
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	0.328482
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	2.10632
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SS-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K42650945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39674
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
ketotifen-3200	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.38469
SPERMINE	DGIdb Drug Targets 2026	1.0	0.345961
GTEX-XQ8I-2026-SM-4BOOL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29753
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
BRD-K37015376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61875
15532095-Table3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10318
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37164
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37129
valproic acid-5569	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
left anterior fascicular block	HPO Gene-Disease Associations	1.0	null
anterior nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10646
MBF transcription complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
detrusor	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.767368
Electrocardiogram - Left Anterior Hemiblock	DisGeNET Gene-Phenotype Associations	1.0	null
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Locus ceruleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.852
Glomus cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.999
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
positive	GeneRIF Biological Term Annotations	1.0	null
regulation of leukocyte mediated immunity	GO Biological Process Annotations 2015	1.0	null
BRD-K15028515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.817
PMC9404532-NIHMS1788564-supplement-Supplementary_Tables_1-8.xlsx-Supp_Table_6-MYC_UP_V1_DN_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_11074_KO_Prkcb_SRP330448	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.15666
Flufenamic Acid	CTD Gene-Chemical Interactions	1.0	null
GSE146687_2_v_3_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.867036
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.47376
PMC7552962__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Timothy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
CHD7	ENCODE Transcription Factor Targets	1.0	null
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE147876,GSE147877_2_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K02715134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21857
glomerular layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230382
OE19	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.58858
GTEX-REY6-2126-SM-48FD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72351
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18523449_mestanolone_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
sodium channel complex	GO Cellular Component Annotations 2023	1.0	null
Nasal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.167
renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072755
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paroxysmal Ventricular Tachycardia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K89742282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03228
Catecholaminergic polymorphic ventricular tachycardia	ClinVar Gene-Phenotype Associations 2025	1.0	null
3557_GSTCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.726174
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63916
BRD-K06296167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80465
Erythrokeratodermia variabilis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
hsa-miR-4710	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-XYKS-2226-SM-4E3IU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65613
securinine-6831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SDHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04816
Prestwick-984-4948	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-PWN1-1426-SM-48TDF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08146
BRD-K62621376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14726
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9362915-pone.0272017.s003.xlsx-Day5_-0_7_Top-BBX_BBX	Rummagene Transcription Factor Associations 2026	1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.7108
BRD-K49865102_PD-0325901_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A8O8-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44684577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58143
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.987976
Perturb_6740_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.89478
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.925
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3A-Down_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162276_2_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
positive regulation of cellular process	GO Biological Process Annotations 2025	1.0	null
SIRPB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616069
HCC1897	CCLE Cell Line Gene CNV Profiles	-1.0	-2.35156
ZNF274	ChEA Transcription Factor Targets	1.0	null
Octreotide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
positive regulation of canonical wnt signaling pathway	GO Biological Process Annotations 2015	1.0	null
Bisphenol A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.773143
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0509
GTEX-QDT8-0126-SM-48TZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834621
aorta thoracica smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193628
RAB3IP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560353
BRD-K25330450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31035
physically	GeneRIF Biological Term Annotations	1.0	null
Salivary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.426
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147056_3_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2-aminobenzenesulfonamide-6321	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AN3CA	CCLE Cell Line Gene CNV Profiles	1.0	1.56081
C8166	DepMap CRISPR Gene Dependency	1.0	2.40704
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.2892
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048677
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K45472595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22259
3776_HIST1H4A_ENST00000359907.3	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.686026
fosfosal-3336	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_1166_KD_ETV6_ERP128093	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
syncope	HPO Gene-Disease Associations	1.0	null
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91043938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.90731
Perturb_17686_OE_HSD17B1_SRP366068	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.89576
right	GeneRIF Biological Term Annotations	1.0	null
methanthelinium bromide-3560	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67075
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ME-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
Glyburide	CTD Gene-Chemical Interactions	1.0	null
MYOD1_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.979973
Skin disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01375
GSE145430_0_v_1_zmat3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IGSF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00479616
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.904699
Cervical epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
PMC10803041-elife-86204-supp2.xlsx-Bulk_-_Snc-KD_in_NM-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SNRPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03203
GSE223008_11_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61020385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02573
DECAVANADATE	DGIdb Drug Targets 2026	1.0	0.622729
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100445_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25558
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4316
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247647
M band	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
BtuCD complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.761
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_4_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Migraine Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
monoatomic ion-gated channel activity	GO Molecular Function Annotations 2025	1.0	null
ascorbic acid-6306	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chlortetracycline-1541	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE-450	GDSC Cell Line Gene Expression Profiles	-1.0	-2.05139
positive regulation of fat cell differentiation	GO Biological Process Annotations 2023	1.0	null
GSE88819_6_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatic acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.413
BRD-K37283718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38884
BRD-U86922168_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Long QT syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EK-01A-22R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC7A9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00467066
Calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.785
Endometrial cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.024
PC-3_[JPC-3]	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.57804
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78247
Kidney Chromophobe_KICH_TCGA-KN-8425-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73416
GTEX-XYKS-1726-SM-4E3IO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892842
posterior group of nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37341
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSNK1A1	KEA Substrates of Kinases	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20163
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
aorta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.150694
UNC119	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570248
BRD-K80198069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19111
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045213
GSE162276_2_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Podosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.83
calcium ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SH-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
enalapril-7026	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-135b	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
NCIH1105	CCLE Cell Line Gene Expression Profiles	-1.0	-2.08939
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K13301506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23525
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Intracranial hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.88
nucleus subceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.882485
BRD-K07278815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20259
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BOD1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23365
cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228162_2_v_5_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40977
PMC12616242-can-24-3452_supplementary_table_s4_suppst4.xlsx-EWSR1-FLI1-KDM6B_genes-Genes_associated_to_EWSR1_FLI1-KDM6B_peaks_in_A-673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148021
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20705
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.839267
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.785
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
scopoletin-6510	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A63759745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4437
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.569
7751_SEC61A1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.71052
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41373
Ion channel transport	Reactome Pathways 2014	1.0	null
BRD-K02708799_GSK-1059615_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dependence	GeneRIF Biological Term Annotations	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.002
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.886116
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3605
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.54
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.966365
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02624
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17595
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lynestrenol-5355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
atrioventricular	GeneRIF Biological Term Annotations	1.0	null
ligand-gated monoatomic cation channel activity	GO Molecular Function Annotations 2023	1.0	null
NCIH647	DepMap CRISPR Gene Dependency	1.0	5.85658
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE195568_1_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal immune system morphology	MPO Gene-Phenotype Associations	1.0	null
LS411N	Achilles Cell Line Gene Essentiality Profiles	1.0	1.00733
brinzolamide-5016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.851728
nalbuphine-5820	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A36630025_-666_THP1_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
channel	Phosphosite Textmining Biological Term Annotations	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
xylometazoline-7020	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.66492
nafcillin-3983	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cardiac conduction	GO Biological Process Annotations 2025	1.0	null
FAM118A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07041
TC71	CCLE Cell Line Gene Expression Profiles	1.0	1.67128
Lung squamous cell carcinoma_LUSC_TCGA-63-7020-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Normal pressure hydrocephalus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.45403
BRD-K69175109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27957
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ABCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15544
CREM	ChEA Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07816
Prostate adenocarcinoma_PRAD_TCGA-EJ-7218-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-4749-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MBTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4892
cochlear ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.550503
Actomyosin contractile ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.73
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.756
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.29966
BRD-K63068307_ZSTK-474_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239784_1_v_0_sat1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81418486_vorinostat_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36784
BRD-K03262163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22235
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09062
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03265
WARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12651
Lung adenocarcinoma_LUAD_TCGA-NJ-A55O-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
henles loop	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.289582
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990114
Glial cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.74098
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T0-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70782
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.21891
Perturb_6118_KO_Fak_SRP279401	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.5788
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6AW-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79318959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84399
H4K20me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
F13A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462284
Mitral cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
Diabetic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03308
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.871
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6692
bundle of His cell action potential	GO Biological Process Annotations 2023	1.0	null
clozapine-5589	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE153662,GSE153664_1_v_0_zeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21064560_PALDA_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Intracranial berry aneurysm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.643
Capillary	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.943
H9c2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
calcium-activated cation channel activity	GO Molecular Function Annotations 2025	1.0	null
TUBA3C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00486611
Pulmonary artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.528
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
smooth	GeneRIF Biological Term Annotations	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
strong	GeneRIF Biological Term Annotations	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20218
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58234
Desmosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.335
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901111
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Sertoli cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
UQCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9607
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitral cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.408212
EKVX	BioGPS Cell Line Gene Expression Profiles	1.0	1.0603
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
testosterone-2649	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLC2A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00385836
Erythrokeratodermia Variabilis	DisGeNET Gene-Disease Associations	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50574
Perturb_9554_KO_Atg16l1_SRP159288	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.9273
NALOXONAZINE-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77215
GSE154767_1_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH146_LUNG	CCLE Cell Line Proteomics	1.0	3.22759
Erythema	DisGeNET Gene-Phenotype Associations	1.0	null
Purkinje myocyte action potential	GO Biological Process Annotations 2023	1.0	null
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19687926_lapatinib_SKBR3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
sodium channel complex	GO Cellular Component Annotations 2025	1.0	null
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.231
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59231
BRD-K68174511_torin-2_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Emery-Dreifuss muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45674
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63926
BRD-K49865102_PD-0325901_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
positive regulation of atrial cardiac muscle cell action potential	GO Biological Process Annotations 2023	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U0-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-6842-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69932463_AZD-8055_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.40705
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7Q0-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6692
BRD-K94647035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39176
BRD-K49371609_528116.cdx_SNUC4_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCDC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28784
tanespimycin-5222	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.981341
fluphenazine-5234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46169
1718_CNOT3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528933
where	GeneRIF Biological Term Annotations	1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.677
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12313
Supraventricular Tachycardia	DisGeNET Gene-Disease Associations	1.0	null
alverine-2273	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.215147
indicates	GeneRIF Biological Term Annotations	1.0	null
K562_Streptozotocin_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151371
Sudden Cardiac Death	DisGeNET Gene-Phenotype Associations	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.801974
J82	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE233679_6_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34256721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18196
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	4.02095
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82494
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53482
GTEX-SNOS-1226-SM-4DM5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73624
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
genistein-1660	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Polycystic kidney disease 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.675
3308_GBF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.942262
Neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.367
Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32282076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38628
inner CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20124
4994_METTL16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0373
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.134
Adrenocortical carcinoma_ACC_TCGA-P6-A5OF-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892116
regulation of t cell cytokine production	GO Biological Process Annotations 2015	1.0	null
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A5RA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUPT1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93395
EXOSC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40101
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clofilium tosylate-3187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF-00562151-00-5959	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Basolateral part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.935
BRD-K28488100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49736
HCC2998	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
diphenhydramine-1830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.254
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
LU-139	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.53837
cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
abnormal vascular permeability	MPO Gene-Phenotype Associations	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6892
NCI-H716	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.593
ZEB2_01_57	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.89533
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RIPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407233
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850849
6867_PSMD13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.525683
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myocardial Infarction_Myocardial tissue_GSE4105	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.72562
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077791
inorganic cation transmembrane transport	GO Biological Process Annotations 2023	1.0	null
valdecoxib-6408	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACTR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00374744
BRD-K62536891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12015
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRG_ESRRG	Rummagene Transcription Factor Associations 2026	1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.864755
GAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519969
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.687
Perturb_12942_KO_YBX1_SRP321707	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.39429
oxedrine-6798	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.1639
Renal distal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.073
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902653
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZR-75-30	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.43351
BRD-K76609014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53839
phensuximide-3521	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYCN2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
572_ASCC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.918023
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.054693
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14393
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.48176
SETD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00430874
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.180339
vascular smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.670878
dendritic cell chemotaxis	GO Biological Process Annotations 2015	1.0	null
PRELID3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42956
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Fetal Kidney	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.2868
apical complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.159074
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.77721
troglitazone-1657	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4266008-mmc3.xlsx-iPS-MSC_vs_MSC-Unnamed_24_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
7419_RPA2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.875481
Enteric plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.577
PMC3190874__F2	PFOCR Pathway Figure Associations 2024	1.0	null
TNFRSF12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00450946
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.911524
Neurosecretory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_DN-Ensemble_gene_ID_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YI-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
noretynodrel-1696	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41186
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970746
Lung adenocarcinoma_LUAD_TCGA-78-7537-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC29A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00939216
positive regulation of cell differentiation	GO Biological Process Annotations 2025	1.0	null
Mutilating palmoplantar keratoderma with periorificial keratotic plaques	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.903
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.669
NR2F2	ENCODE Transcription Factor Targets	1.0	null
SNU-475	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CCRF-CEM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K68595406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.45711
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GE-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72997741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17176
GSE154074_5_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Transport of small molecules	Reactome Pathways 2024	1.0	null
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.97181
regulation of cell proliferation	GO Biological Process Annotations 2015	1.0	null
sporadic	GeneRIF Biological Term Annotations	1.0	null
GSE135350_2_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
8305C_THYROID	CCLE Cell Line Proteomics	1.0	2.46962
sodium ion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
degeneration	GeneRIF Biological Term Annotations	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964081
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2074
HCC1187	CCLE Cell Line Gene Expression Profiles	1.0	1.58336
GTEX-QDVJ-1326-SM-48U1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26611
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the cardiovascular system	HPO Gene-Disease Associations	1.0	null
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
DDX56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19291
circulatory system process	GO Biological Process Annotations 2015	1.0	null
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal professional antigen presenting cell physiology	MPO Gene-Phenotype Associations	1.0	null
NCIH2126	CCLE Cell Line Gene Expression Profiles	1.0	1.40496
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.75865
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10367
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K18190982_COT-10b_JHUEM2_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Duodenal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.038
BRD-K05718365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77297
Neuronal cell body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GSE82104,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97721960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31651
SKIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09883
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16054
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05752
GTEX-WFG7-1326-SM-4LMK1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.121
Ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.423
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05253
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.89692
Heart ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.635
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ioxaglic acid-3528	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41867
Lung squamous cell carcinoma_LUSC_TCGA-94-8491-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147669_2_v_1_tram2_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH2286	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53707
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39013648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27955
PMC5550424-41467_2017_212_MOESM4_ESM.xlsx-Hematlas-Genesets-ZNF257_ZNF257	Rummagene Transcription Factor Associations 2026	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Chromaffin cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.296
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910441
Pancreatic islet cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.039
Femoral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68053
amantadine-4222	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
isolated	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Myocardium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.776
VSTM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611031
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
6863_PSMC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.682227
ETS1	ENCODE Transcription Factor Targets	1.0	null
outer CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06835
Perturb_644_OE_ERG_SRP344038	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.36346
HCC1395	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09288
MPP89	DepMap CRISPR Gene Dependency	1.0	5.73839
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.16434
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Lymph node carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
9747_VPS28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.009
GSE147366_1_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S95S-1026-SM-4B64M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16669
Pain disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
GTEX-QCQG-0526-SM-48U2A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06553
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF367	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00775948
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054229
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J6-01A-31R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
contraction	GeneRIF Biological Term Annotations	1.0	null
MYC-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K21680192_mitoxantrone_BT20_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.368
Gastrointestinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18428
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88378636_withaferin-a_SKBR3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K20586104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6264
KCNQ5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493945
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
prostate gland epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K27881972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22966
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of cardiac muscle cell contraction	GO Biological Process Annotations 2025	1.0	null
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075232
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.890971
Foramen magnum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
GTEX-U412-0426-SM-3DB9O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05729
GTEX-V1D1-1926-SM-4JBGX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76306
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48785
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.17067
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K87909389_alvocidib_MDAMB231_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24207
BRD-K03449891_foretinib_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
aminocaproic acid-6501	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
atp	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37656403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1854
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7353
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.614
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964783
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24328
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37120019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50922
BRD-K81418486_vorinostat_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LAMA84	Achilles Cell Line Gene Essentiality Profiles	1.0	1.0326
ADK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502205
colonrectum_f	HPA Tissue Sample Gene Expression Profiles	1.0	1.25297
Aortic smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.938
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.939634
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC33	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84801
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.247719
embryoday7.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.937917
GTF2B	ENCODE Transcription Factor Targets	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04755
Mitral cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
CCRL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00693901
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.866117
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
channel activity	GO Molecular Function Annotations 2015	1.0	null
smallintestine_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.859575
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Arterial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.019
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.929
Selinexor _LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00596566
Hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.076
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08334
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9125579__F10	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K07101857_NCGC00183216-01_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X5EB-1626-SM-4E3IV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28713
BRD-K83270266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52749
bundle of His cell action potential	GO Biological Process Annotations 2025	1.0	null
DFFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06465
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61882
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20947
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
valinomycin-5962	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
desumoylation	GeneRIF Biological Term Annotations	1.0	null
7827_SET_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544358
PMC8803621-mmc6.xlsx-Sup_Fig5A_genes_list-Genes_with_following_MEF2_motifs_around_their_TSS_CTAWWWATA_RSRFC4_Q2_MEF2_Q6_01_MEF2_03_MEF2_02_RSRFC4_Q2_from_GSEA_MEF2A	Rummagene Transcription Factor Associations 2026	1.0	null
Basolateral plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.768
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.957577
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102675_3_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.845864
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	209.317
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74568359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17876
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946235
SNB-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.238
mineral metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.075703
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-A4M5-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Phrenic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.044
BRD-K98431828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22474
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.15763
5074_MIIP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.748772
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.903782
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532505
Urinary bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.651
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73616
TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
cation channel complex	GO Cellular Component Annotations 2023	1.0	null
BRD-K50168500_canertinib_SKBR3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K47338154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54486
MCF7_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136319
GSE210580_5_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary Bundle Branch System Defect	DisGeNET Gene-Disease Associations	1.0	null
causative	GeneRIF Biological Term Annotations	1.0	null
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.142038
TLR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569182
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Congestive Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
9172_TONSL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.62768
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE198794_0_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29345
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	3.86079
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_NFIX-Logfold_change_threshold_1_0_1_NFIX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19500257_geldanamycin_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Microtubule plus-end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96183
LNCAPCLONEFGC	CCLE Cell Line Gene Expression Profiles	1.0	1.6669
BRD-K67868012_PI-103_LNCAP_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IFNGR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590624
BRD-K52300725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31909
B3GAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489059
PMC7360734-41467_2020_17206_MOESM9_ESM.xlsx-OCI-AML3-Unnamed_0_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12079898_PD 160170_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
single organism signaling	GO Biological Process Annotations 2015	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC2866657-pone.0010547.s003.xls-ERG_corr-Genes_correlated_anticorrelated_to_ERG_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Long QT syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.523
pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.156718
Middle cerebral artery infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
BRD-K59386816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14638
GTEX-OXRL-2626-SM-2I3F1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07175
niflumic acid-7430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE199204,GSE211619_4_v_5_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of bone mineralization	GO Biological Process Annotations 2025	1.0	null
BRD-K19527338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0412
Right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.084
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
underlies	GeneRIF Biological Term Annotations	1.0	null
tinidazole-4548	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q734-1926-SM-2I5EV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885824
GSE169571_5_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
prostate_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.906497
GSE241031_0_v_7_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.118
ATP1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00375401
CSF3R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555766
BRD-K29969800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90894
Cardiopulmonary Arrest	DisGeNET Gene-Phenotype Associations	1.0	null
PRPF4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614993
Epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Left ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.405
Arrhythmogenic right ventricular dysplasia 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835212
Lung adenocarcinoma_LUAD_TCGA-86-A4JF-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77046858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13707
chlortalidone-3198	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K81372179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06289
fluticasone-7348	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of Wnt signaling pathway	GO Biological Process Annotations 2023	1.0	null
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15883
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74148702_curcumin_SNUC4_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81651477_Parthenolide_RMGI_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
positive regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
negative regulation of ossification	GO Biological Process Annotations 2025	1.0	null
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_14971_KD_Crebbp_SRP154933	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.074
RL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K00418890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17832
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02624
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.01259
etanidazole-6072	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Arachnoid mater	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
bambuterol-5885	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pulmonary artery smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.137
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPJH-0226-SM-3GADV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872627
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CACNG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00598648
TRPM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622403
propofol-6707	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A19037878_trichostatin A_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-2355-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
BRD-K16943897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47158
15342375-Table3	GeneSigDB Published Gene Signatures	1.0	null
Cystic Fibrosis	DisGeNET Gene-Disease Associations	1.0	null
Perturb_10125_KD_ACP1/APC2_SRP061848	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.21409
alphacells	GeneRIF Biological Term Annotations	1.0	null
Diabetes Mellitus	CTD Gene-Disease Associations	1.0	1.25619
BRD-K60623809_SU11652_SNUC4_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CXCL13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478098
Forestomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.287
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19495
Disseminated Malignant Neoplasm	DisGeNET Gene-Phenotype Associations	1.0	null
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Cheek pouch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.259
Vestibular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.398
Mast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.229
EOMES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28962
MAFK	ENCODE Transcription Factor Targets	1.0	null
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.8462
BRD-K96069147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43953
PMC10710060-pnas.2305135120.sapp.pdf-8-SRF_SRF	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YW-1426-SM-3MJHF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13801
sensitivity	GeneRIF Biological Term Annotations	1.0	null
Overactive bladder syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.863
Perturb_15688_KO_Rel_SRP075924	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.09105
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9933
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ADENOSINE TRIPHOSPHATE	DGIdb Drug Targets 2026	1.0	0.183156
vascular smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224893
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.0608
conduction	GeneRIF Biological Term Annotations	1.0	null
GSE230744,GSE237803_5_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR3C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495933
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.56826
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urethra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.279612
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91052
encephalomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.190476
pkcdependent	GeneRIF Biological Term Annotations	1.0	null
sodium	GeneRIF Biological Term Annotations	1.0	null
SCN5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00757937
GTEX-UPIC-1626-SM-4IHKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13921
GSE149366_1_v_0_sulconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.48277
YKG1	DepMap CRISPR Gene Dependency	1.0	3.62505
HDAC6	ENCODE Transcription Factor Targets	1.0	null
abnormal immune system physiology	MPO Gene-Phenotype Associations	1.0	null
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.954446
ESRRB	ChEA Transcription Factor Targets	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.10171
BRD-K56234278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66517
Bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.794
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.899068
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
7155_RBM14-RBM4_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.602945
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72126
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Roxatidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02031
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-BRCA2_156_TCF7_rep1_sorted_peak-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO Biological Process Annotations 2023	1.0	null
second-degree atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
EJM	CCLE Cell Line Gene Expression Profiles	1.0	1.53009
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02606
GTEX-NPJ8-0326-SM-2D7VV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851598
BRD-K67868012_PI-103_SKBR3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K96037667_19-norethindrone_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
monorden-1219	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.84869
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
BRD-K52285987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05518
Autosomal dominant polycystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.699
ligand-gated monoatomic cation channel activity	GO Molecular Function Annotations 2025	1.0	null
hsa-miR-199a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
BRD-K87990216_Piretanide_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE154074_5_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_0_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
sulfamonomethoxine-5843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Selisistat_10µM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0105242
Perturb_11877_OE_miR30a3p_SRP238971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.5623
Cell body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
PRKCA	PhosphoSitePlus Substrates of Kinases	1.0	null
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.976505
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Exocrine acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
midodrine-6804	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K69328504_L-690,488_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K45095313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49637
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17691
filter	GeneRIF Biological Term Annotations	1.0	null
GTEX-QVJO-1626-SM-2S1QW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925453
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19617
10737_ZWILCH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530746
sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.988032
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T5-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.0151
KLF4-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.82
channel	GeneRIF Biological Term Annotations	1.0	null
tyloxapol-5672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
divalent metal ion transport	GO Biological Process Annotations 2015	1.0	null
Ventricular fibrillation	ClinVar Gene-Phenotype Associations 2025	1.0	null
BRD-K69852452_F1566-0341_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NTRK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0046276
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366777
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.938637
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EW-1	GDSC Cell Line Gene Expression Profiles	1.0	1.48377
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25887
peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.277197
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04254
abnormal ion homeostasis	MPO Gene-Phenotype Associations	1.0	null
ICAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00314781
Connexin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.249
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCB000038-7516	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Agranular insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
Ciliary membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.014
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517659
BRD-K49745983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15131
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03699
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23623
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045299
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03697
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
ovary	GTEx Tissue Gene Expression Profiles	-1.0	-1.1147
VCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86257
Brain Lower Grade Glioma_LGG_TCGA-FG-A87Q-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_Targetome-Genes_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
RASGRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00637413
nitrendipine-5405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
uropod	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.262025
BRD-K09499853_KU 0060648 trihydrochloride_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6866_PSMD12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.685935
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02105
Artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.257
NCI-H1105	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34482
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75081836_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35112
disopyramide-7276	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DTX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00541676
valproic acid-6974	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
provide	GeneRIF Biological Term Annotations	1.0	null
Cribriform plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390313
betonicine-4301	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K02708799_GSK-1059615_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K78288885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44176
BRD-A58280226_Y-27632_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5325343-oncotarget-07-63003-s002.xlsx-Supplementary_Table_1-Supplementary_Table_1_Genes_upregulated_by_EWS-FLI1_in_the_Gordon_et_al_data_set_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
SDF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00742774
K562_Entacapone_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169875
CIRBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0043408
trpc3	GeneRIF Biological Term Annotations	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.0506
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044221
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.036
BRD-A79479878_testosterone_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.246
regulation of wnt signaling pathway	GO Biological Process Annotations 2015	1.0	null
GTEX-S32W-1226-SM-4AD67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862171
valproic acid-1214	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
vasoconstriction	GO Biological Process Annotations 2015	1.0	null
abnormal calcium ion homeostasis	MGI Mouse Phenotype Associations 2023	1.0	null
LU-139	GDSC Cell Line Gene Expression Profiles	-1.0	-2.22268
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880286
mediodorsal nucleus of thalamus_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04789
Heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.384
Prostate	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A45889380_QUINACRINE HYDROCHLORIDE_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	198.575
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14111
artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.071307
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
form	GeneRIF Biological Term Annotations	1.0	null
BRD-K90543092_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
branch	GeneRIF Biological Term Annotations	1.0	null
GTEX-UJHI-1526-SM-3DB99	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02912
1013_C18ORF32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.668535
BRD-K82928847_rocilinostat_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IMCD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.877
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
atp	GeneRIF Biological Term Annotations	1.0	null
Aorta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.487
brain edema	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.179239
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.872886
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6692
IL5RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554249
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
icSARA deltaORF6_48Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.33926
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.40928
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61016
MYB_01_44	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.07027
Autoimmune disease of skin and connective tissue	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
doxycycline_mus musculus_gpl2872_gse33875	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.092
Piperonyl Butoxide	CTD Gene-Chemical Interactions	1.0	null
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89832379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23769
GSE147876,GSE147877_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BEND3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00730108
BRD-K76588894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12261
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.36856
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21872
Uveal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
Cerebrovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
Prostate adenocarcinoma_PRAD_TCGA-J4-A83J-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.890262
PMC8047323-Table_1.xlsx-FC_LPS_T24_Vs_LPS_T0_P_0_05_FC-GeneSymbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
7979_SLC22A23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536926
CRYBB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520819
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.01262
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BLM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536038
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Junctional membrane complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
Ishikawa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.93
Venule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.135
Long QT syndrome 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
effect	GeneRIF Biological Term Annotations	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064642
sodium ion transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.86572
KM-H2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.93715
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.4274
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29272
NCIH2170	CCLE Cell Line Gene CNV Profiles	1.0	1.89025
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.0253
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23713
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24496482_SB590885_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prostate	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.25696
minaprine-1468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67868012_PI-103_SKBR3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8410-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.432225
18787207-TableS2	GeneSigDB Published Gene Signatures	1.0	null
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.352142
Neuroinflammation and glutamatergic signaling	WikiPathways Pathways 2024	1.0	null
phorbol	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.869825
regulation of immune effector process	GO Biological Process Annotations 2015	1.0	null
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Palmoplantar keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
abnormal hypersensitivity reaction	MPO Gene-Phenotype Associations	1.0	null
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11399
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20J-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.955509
atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.419892
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045636
signaling	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1912
OVCAR-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
droperidol-4629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.09711
Uropod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.962
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02446
calcium ion transport	GO Biological Process Annotations 2023	1.0	null
BRD-K07276022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53833
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
3D4/21 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RUNX1	ChEA Transcription Factor Targets	1.0	null
5587_NEDD8-MDP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540636
TYKNU	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.48859
non-neuronal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.395
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49796
SK-LMS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52743
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29458
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Right Bundle Branch Block	DisGeNET Gene-Disease Associations	1.0	null
WT1	ChEA Transcription Factor Targets	1.0	null
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OPTN_KD_GDS2892_268_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
DCTD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08612
RINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06094
left bundle branch block	HPO Gene-Disease Associations	1.0	null
3978_HSPA5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.13046
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89664
LAIR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00856712
1718_CNOT3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.718355
Uterine endometrial cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
cardiac purkinje fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.912653
Phospholamban complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.431
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sarcolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.235607
OCI-AML2	GDSC Cell Line Gene Expression Profiles	1.0	1.89005
spermine	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-A35588707_TENIPOSIDE_THP1_6.0_h_1.25_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cinoxacin-3463	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Progressive familial heart block	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44664883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41019
mianserin-2231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A25416824_NRB 03823_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	336.929
BRD-K40251180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53318
Progressive familial heart block type 1B	ClinVar Gene-Phenotype Associations	1.0	null
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8635
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04669
LRF	MotifMap Predicted Transcription Factor Targets	1.0	null
PCM6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53925
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K96898856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4435
vascular process in circulatory system	GO Biological Process Annotations 2015	1.0	null
dendritic cell chemotaxis	GO Biological Process Annotations 2023	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adiphenine-7037	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H2135	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.52069
GSE116492,GSE116495_3_v_1_stag2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.843
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.16287
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.855252
EW8	CCLE Cell Line Gene Expression Profiles	1.0	1.76088
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.32285
KCNAB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477063
LS-180 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071009
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFON-1626-SM-4LVMV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13155
BRD-K22988729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24251
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92192
metabolic process	GO Biological Process Annotations 2015	1.0	null
tetrahydroalstonine-5728	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EmrE multidrug transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.748
HL-60	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71605
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HL-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.736
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14111
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18538
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926072
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.911
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878847
six	GeneRIF Biological Term Annotations	1.0	null
SPIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684919
PMC12077394-giaf035_giga-d-24-00380_revision_1.pdf-15-HMG20B_HMG20B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39328339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68095
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
supramolecular	GeneRIF Biological Term Annotations	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375387
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.443
furaltadone-3838	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3487
7634_SAE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.781099
vascular smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.912226
Axon terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.628
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Atrophy	CTD Gene-Disease Associations	1.0	1.2975
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077988
valproic acid-1665	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Genetic disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
Nkx-2.5 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.414
pepstatin-3264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE190761_0_v_1_samd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3190874__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Aortic valve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
modulator	GeneRIF Biological Term Annotations	1.0	null
vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.935799
Tooth enamel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
HS 839.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07665
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.648
LSM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478204
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828876
BRD-K15201964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06929
plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.733319
Carotid sinus nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
Cardiac arrest	ClinVar Gene-Phenotype Associations 2025	1.0	null
2567_EIF4E_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.641339
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Cardiovascular system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.939654
PML	ENCODE Transcription Factor Targets	1.0	null
GTEX-WK11-0526-SM-3NB3O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92257
RBL-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
PON1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553809
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26906
Capillary pericyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.872
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
epirizole-1681	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Flavopiridol HCl_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134341
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormal cardiovascular system physiology	MPO Gene-Phenotype Associations	1.0	null
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
action	GeneRIF Biological Term Annotations	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.963794
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27743
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.963708
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
JEKO1	CCLE Cell Line Gene Expression Profiles	1.0	1.51847
17597811-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18114
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.379
BMS-911543	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
JVM3	DepMap CRISPR Gene Dependency	1.0	2.83798
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.984589
cell motility	GO Biological Process Annotations 2015	1.0	null
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ACVRL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485331
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17737
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lamina epithelialis mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
M07E	CCLE Cell Line Gene CNV Profiles	1.0	1.36593
BRD-K38970027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36042
DGKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539917
GSE60837_6_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21775
BRD-K85606544_neratinib_SKBR3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72770355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38003
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T5JC-0326-SM-4DM5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17555
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.798
sulfamonomethoxine-7200	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal type i hypersensitivity reaction	MPO Gene-Phenotype Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1081-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_5619_KD_RNF168_SRP157910	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7027
MEP1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00451994
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06912
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35592
CUX1	ENCODE Transcription Factor Targets	1.0	null
Spinal trigeminal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
BRD-K94790210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4071
FEM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62015
BRD-K10987837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.8326
protein homotetramerization	GO Biological Process Annotations 2025	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.617
AGTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555741
nucleoplasm	GO Cellular Component Annotations 2015	1.0	null
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	6.76409
Periglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
regulation of canonical Wnt signaling pathway	GO Biological Process Annotations 2023	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MTNR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00708348
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of vasoconstriction	GO Biological Process Annotations 2025	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CNR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00908382
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Migraine with Aura	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
L-428	COSMIC Cell Line Gene Mutation Profiles	1.0	null
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.00871
PMC12183081-41388_2025_3375_MOESM8_ESM.xlsx-Sheet1-Table_S7_List_of_differentially_alternative_splicing_genes_in_osteosarcoma_cell_lines_after_knocking_down_the_YBX1_gene_P_0_05_Related_to_Fig_6C_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Prestwick-682-6638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TUR	GDSC Cell Line Gene Expression Profiles	1.0	2.34158
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75192396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27602
FHF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
assembly	GeneRIF Biological Term Annotations	1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.885655
inorganic cation transmembrane transport	GO Biological Process Annotations 2025	1.0	null
long qt syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.539667
trpm4	GeneRIF Biological Term Annotations	1.0	null
impaired	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K22280519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14575
ventrolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0666
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
BPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627483
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.29533
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980005
autoimmune	GeneRIF Biological Term Annotations	1.0	null
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.14473
protein sumoylation	GO Biological Process Annotations 2023	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01476
COS-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.436
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1236
Interventricular septum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.792
Stormorken syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
YAP1	ChEA Transcription Factor Targets	1.0	null
Gracilis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03068
MECLOFENAMATE	DGIdb Drug Targets 2026	1.0	0.622729
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.718
sodium-phenylacetate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10658
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18565
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
channels	GeneRIF Biological Term Annotations	1.0	null
regulation of bone mineralization	GO Biological Process Annotations 2023	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06869
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TK-01A-42R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
loss	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K73391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49552
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04148
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYB5D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00850136
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.09528
COV644	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.3061
MCF7_WHI-P154_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131283
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mesoridazine-2874	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HT1376	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40236
IL17C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581995
BRD-K24020784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20914
SNU840	DepMap CRISPR Gene Dependency	1.0	2.38523
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0485
BRD-K84439371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47658
POU5F1	ChEA Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MN-A4N4-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.271952
GSE207433_2_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.238706
GSE125211_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03052
BRD-K79259477_KIN001-265_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.618268
ciclacillin-3800	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KYSE-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K98020844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69421
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35224
PMC5119679__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE188458_2_v_0_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Basal part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.921
BRD-K43261169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34506
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Acute pancreatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane depolarization during Purkinje myocyte cell action potential	GO Biological Process Annotations 2025	1.0	null
GCIY	CCLE Cell Line Gene CNV Profiles	1.0	2.59968
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K80782159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49693
Hypoglossal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.935
Brugada Syndrome	DisGeNET Gene-Disease Associations	1.0	null
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PFSK-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.72797
regulation of T cell cytokine production	GO Biological Process Annotations 2023	1.0	null
MEC1	DepMap CRISPR Gene Dependency	1.0	2.16727
BRD-K57226184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23848
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.10177
GSE193351_1_v_3_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4317_KDM1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	2.19785
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nasal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191625
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.73507
NCI-H716 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2862
GSE154074_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983293
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12582
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22344
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of heart contraction	GO Biological Process Annotations 2023	1.0	null
MYOD1_myocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A56592690_PX12_SNUC4_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_2_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
indicating	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-1226-SM-4AT67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41296
NCI-H2023	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4T7-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYSE-410	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_1175_KD_CBFB_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.71159
TNPO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03054
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.61621
BRD-K04969760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42387
Piriform area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GL-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHA-00745360-4559	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_1586_KO_Myd88_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.27665
monastrol-311	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08333
AV node cell action potential	GO Biological Process Annotations 2025	1.0	null
pulmonary hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.296931
bromperidol-2872	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.594843
BRD-K30013099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47525
Transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.253
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VCAP	DepMap CRISPR Gene Dependency	1.0	2.10167
IGSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666251
calmodulin binding	GO Molecular Function Annotations 2015	1.0	null
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ECC4	DepMap CRISPR Gene Dependency	1.0	4.84618
membrane depolarization during Purkinje myocyte cell action potential	GO Biological Process Annotations 2023	1.0	null
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.92447
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39555
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.84085
Exocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.412
KAP1-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08508
Peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.0
hexamethonium bromide-4965	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
P31-FUJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
vinpocetine-7213	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
adipogenesis	GeneRIF Biological Term Annotations	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
meprylcaine-5723	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CYP21A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0064089
hsa-miR-4447	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
PMC7912581__F2	PFOCR Pathway Figure Associations 2024	1.0	null
regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
depolarizing	GeneRIF Biological Term Annotations	1.0	null
GTEX-XPVG-2126-SM-4B667	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999556
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oxybuprocaine-1476	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41885
BRD-K89992188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12998
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13809
positive regulation of multicellular organismal process	GO Biological Process Annotations 2025	1.0	null
BRD-K80166820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29558
EOL1	CCLE Cell Line Gene Expression Profiles	1.0	1.80628
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Familial episodic pain syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.805
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-2.10009
BRD-K89376872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.86928
acetazolamide-1686	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TRP channels	Reactome Pathways 2024	1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
KASUMI1	DepMap CRISPR Gene Dependency	1.0	4.58815
GTEX-RM2N-0926-SM-48FD1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21194
PPP3CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38869
BRD-K93747373_HG-5-113-01_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.768
TBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17288
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.85675
laevis	GeneRIF Biological Term Annotations	1.0	null
MAFK_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fulvestrant-6997	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.07309
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Chemoreceptor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.065
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	3.39351
blood vessel endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.364139
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27271
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.885662
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	198.011
PHA-00846566E-7081	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70305913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73589
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	190.618
residue	GeneRIF Biological Term Annotations	1.0	null
Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
voltagesensing	GeneRIF Biological Term Annotations	1.0	null
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
colon	GTEx Tissue Gene Expression Profiles	1.0	1.70899
VSIG10L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625577
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01393
MSH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32998
TTI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23491
Hs-746T	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.40461
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
INS-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BV-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.865
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.84656
GSE103297_1_v_0_glis3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS 895.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06254
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.9228
RL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84814
Transcription export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.881
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09005
lateral group of nuclei, right, ventral division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.287
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71023
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fulvestrant-5964	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
guanabenz-5703	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
terminus	GeneRIF Biological Term Annotations	1.0	null
aorta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233162
l138.8a	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
Ionotropic glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.296
8923_TIMM44_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.837426
GSE157777_1_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.476589
CRCGN008_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10465
TCFCP2L1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GIMAP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00789477
phrenic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.303559
GTEX-S7SE-0126-SM-2XCD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08801
EBI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522976
SLC66A1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00875187
GTEX-U412-2026-SM-4DXSI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13717
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
c-MYC_KD_GDS2526_113_human_MDA-MB-231 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Cerebral arterial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.546
used	GeneRIF Biological Term Annotations	1.0	null
paclitaxel-1542	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5303304-13073_2017_407_MOESM5_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_4-Table_S4_Genes_differentially_expressed_by_48h_Dox_MYCN_overexpression_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GSE182180_1_v_2_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81P-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24343201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41598
BRD-K50168500_canertinib_SKBR3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE148066,GSE157787_5_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11630986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27748
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17553044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1568
Stimuli-sensing channels	Reactome Pathways 2024	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T cell and NK cell immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
encephalomyelitis	GeneRIF Biological Term Annotations	1.0	null
arteriole	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.350743
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Intercalated disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.545
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.689782
Periodontal ligament cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.914837
GZMH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553504
hsa-miR-3192	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K51313569_palbociclib_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52210941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5059
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043478
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.406238
proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.282558
decreased dendritic cell number	MPO Gene-Phenotype Associations	1.0	null
TRPV4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625408
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59445060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27197
PDGFRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30122
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LIVF001-018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20785
PMC10787250-BLOODA_ADV-2022-008899-mmc1.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_commonly_up-_or_downregulated_in_CBFA2T3_GLIS2_leukemia_GLIS2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11396
BRD-K78062244_STOCK1N-27488_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Arteriole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.889
GSE169155_5_v_4_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-1426-SM-4LVMT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95713
PMC11960529-mmc4.xlsx-Ventricular_ZNF711_KOoverCT-gene_ZNF711	Rummagene Transcription Factor Associations 2026	1.0	null
Corpus cavernosum smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
NCI-H292	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Adenosine Triphosphate	CTD Gene-Chemical Interactions	1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.02618
metal ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
olfactory lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.184165
GSE121809_1_v_0_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.54767
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.58322
GTEX-R55F-0126-SM-48FCK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2143
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K34581968_BMS-536924_HCC515_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040803
BRD-K89638177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27169
neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.320454
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4604
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85367
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961869
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.932595
BRD-K90686530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13766
positive regulation of atrial cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
carmustine-6888	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Tooth germ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Upregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PSTPIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00857941
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HA-01B-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
picotamide-6787	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.67586
OCIAML2	CCLE Cell Line Gene Expression Profiles	1.0	2.47161
GTEX-WRHU-2826-SM-3MJG8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929356
troglitazone-1232	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24246830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65839
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
GRIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484532
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3199	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-WOFL-0726-SM-3MJG4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02492
Prostate adenocarcinoma_PRAD_TCGA-G9-6343-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NKAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00547
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05305
6351_PIK3C2A_ENST00000265970.7	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.76949
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56939159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12416
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	GeneRIF Biological Term Annotations	1.0	null
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28481
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.41998
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_UPREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
leukocyte migration	GO Biological Process Annotations 2015	1.0	null
9583_UHRF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511256
regulation of production of molecular mediator of immune response	GO Biological Process Annotations 2015	1.0	null
GSE192689_0_v_3_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26349
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14194
BRD-K00048792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05807
IRF4_01_262	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.35318
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054691
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Capillary endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.33
duodenum_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.842688
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
hsa-miR-1	MiRTarBase microRNA Targets	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50216176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18289
BRD-K67120755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04259
MCF7_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182694
BRD-K03343162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07108
physiological	GeneRIF Biological Term Annotations	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.70695
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.34576
NBA	DGIdb Drug Targets 2026	1.0	3.11365
ion transport	GO Biological Process Annotations 2015	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29285
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.84763
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.98465
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4Q7-0826-SM-4AD5E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6916
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5162
MCF7_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114651
PMC7608835-aba3058_Table_S4.xlsx-EWS-FLI1_RING1B-Genes_containing_RING1B_EWSR1-FLI1_enhancers_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17916
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5083-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056028
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.501965
cardiac muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.604099
MLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5077
ZKSCAN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2898
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tanespimycin-5958	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Colon muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
regulation of canonical wnt signaling pathway	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5715-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212413
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.937033
Urinary bladder smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.58
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.58648
NB14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K25394294_oxaprozin_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-A4M6-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
canavanine-4197	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5813
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	173.589
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13689
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
diclofenac-2756	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DKMG	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.62729
BRD-K63068307_ZSTK-474_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HSD17B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00730188
endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-A71459254_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28959
RAD51C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00387182
FAM8A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22008
EMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04393
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
outer CP in (rostral) midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.919639
BRD-K37687095_AZD-8330_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
regulation of immune response	GO Biological Process Annotations 2015	1.0	null
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.83719
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
geldanamycin-972	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
calcium activated cation channel activity	GO Molecular Function Annotations 2023	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
increased susceptibility to type i hypersensitivity reaction	MPO Gene-Phenotype Associations	1.0	null
Transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
cytokine	GeneRIF Biological Term Annotations	1.0	null
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12805
7753_SEC61G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.722327
inaD signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
FAM32A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21502
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68305833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14574
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4645_LRIF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502797
dendritic cell migration	GO Biological Process Annotations 2023	1.0	null
PMC11033585-BLOOD_BLD-2023-021752-mmc2.xlsx-S11_DGEA_CDKN2A_PAX5-Supplemental_Table_11_Differentially_expressed_genes_between_CDKN2A_PAX5_and_all_other_subcluster_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
monoatomic cation transport	GO Biological Process Annotations 2025	1.0	null
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29685390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05538
TET1-21490601-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC3012182__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Mucosal mast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
9592_UNC45A_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.772627
BMMC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.185
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
possesses	GeneRIF Biological Term Annotations	1.0	null
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090655
HCC-827	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.35973
bupivacaine-7435	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
autosomal dominant inheritance	HPO Gene-Disease Associations	1.0	null
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116446
cterminal	GeneRIF Biological Term Annotations	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969086
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Trachea	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05089
GCIY	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
BRD-U28903152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08251
AM-095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.62567
BRD-K69775722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87714
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.50019
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G1-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Scapuloperoneal spinal muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
BRD-K04810287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55603
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A172	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60582
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0033224
BRD-K61494613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95081
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917914
BRD-K97452545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12258
Uterine Diseases	CTD Gene-Disease Associations	1.0	1.13484
positive regulation of Wnt signaling pathway	GO Biological Process Annotations 2025	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29285
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0253
GTEX-S7SF-1926-SM-4AT5B	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16551
clitoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.17774
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55665
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.97631
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09866
ASMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612045
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.92184
GTEX-UPIC-1126-SM-4IHLO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31568
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43057
GTEX-QDVN-1226-SM-48TZ5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17351
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3502
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.341
BRD-K49328571_dasatinib_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
leukocyte chemotaxis	GO Biological Process Annotations 2015	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Neonatal diabetes	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-7774-01A-21R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
frontal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.171696
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.734
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.511
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of bone mineralization	GO Biological Process Annotations 2023	1.0	null
thioridazine-5227	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4P3-0926-SM-4AD54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831267
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10106
cardiac muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.831966
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
SK-LMS-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.31356
BRD-K14723547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89419
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
sulpiride-1467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154549
GSE121866_1_v_3_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DOHH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663097
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
MV411	CCLE Cell Line Gene Expression Profiles	1.0	1.6752
bladder wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.698625
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51594
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1581	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44035
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10803041-elife-86204-supp2.xlsx-Bulk_-_Snc-KD_in_HT-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE115763_3_v_1_klf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27618188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38856
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EK-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC12A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660081
GSE116810_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.83835
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
selectivity	GeneRIF Biological Term Annotations	1.0	null
GSE126776_2_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060496
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.7235
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64800655_PHA-793887_HS578T_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AGS	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.07835
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
binding	GO Molecular Function Annotations 2015	1.0	null
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65485
MYC	ChEA Transcription Factor Targets	1.0	null
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080983
SNU182	DepMap CRISPR Gene Dependency	1.0	3.66502
GSE146982_3_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128272
BRD-K25718630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05357
Right ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.598
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB	DepMap CRISPR Gene Dependency	1.0	2.30804
BRD-K48488978_YM-201636_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
oxprenolol-7225	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10515843-media-1.xlsx-Table_7_Diff_loop_genes_E_v_S-Supplementary_Table_7_Genes_that_involve_significant_differential_looping_in_pediatric_primary_B_cell_CTCF_peaks_compared_to_GM12878_CTCF_peaks_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
inferior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.8189
Multiple Sclerosis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K84955386_hyperoside_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.16905
abnormal dendritic cell physiology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K92312193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21874
GSE160373_1_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28448768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50636
negative regulation of biomineral tissue development	GO Biological Process Annotations 2025	1.0	null
Neuroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.241
CRCGN015_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26027
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MW-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08939947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.26232
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
GSE198165,GSE198166_9_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14875
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16042
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84036904_methyltestosterone_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GCDH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00645079
14767473-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
vinblastine-7517	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Calcium	HMDB Metabolites of Enzymes	1.0	null
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8143-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pulmonary vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
localization	GO Biological Process Annotations 2015	1.0	null
Apical proximal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.38
Holt-Oram syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K24156533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68105
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08757
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
sclerosis	GeneRIF Biological Term Annotations	1.0	null
HCC4006	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35387
embryoday10.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.38275
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.574
ELF1	ENCODE Transcription Factor Targets	1.0	null
Peripheral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.598
KARPAS-422	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59439
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLM13	CCLE Cell Line Gene Expression Profiles	1.0	1.64751
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ventricular Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
BRD-K73200916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52367
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061968
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal atrioventricular conduction	HPO Gene-Disease Associations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13819
urapidil-6455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01857
tiletamine-6013	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SR	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
pioglitazone-7083	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of fat cell differentiation	GO Biological Process Annotations 2025	1.0	null
Perturb_9584_KO_Vdr_SRP115411	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.65978
first-degree atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.293866
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13177
BRD-K43359161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16237
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18713946-TableS3	GeneSigDB Published Gene Signatures	1.0	null
methoxamine-6627	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRC2_EDD_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TB-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Diffuse large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
KIR2DS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00578197
Prostate carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
GSE207471_2_v_3_btla_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98281
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.950817
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03419
Aortic valve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
BRD-K04546108_JAK3 Inhibitor VI_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1592
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
dihydrostreptomycin-2074	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cation channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.419252
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_17359_OE_CREB_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.74481
496100642_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29648
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07311
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
axonal	GeneRIF Biological Term Annotations	1.0	null
internal segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.873526
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCL24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0046115
heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.42289
BRD-K76908866_CP-724714_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TC32	CCLE Cell Line Gene Expression Profiles	1.0	1.64027
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-1226-SM-4DM5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05664
BRD-K76544773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22295
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.55
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
adenosine	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
KKU100	DepMap CRISPR Gene Dependency	1.0	3.87711
GSE180185_7_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.163571
Cardiac muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.177
PMC12077394-giaf035_giga-d-24-00380_original_submission.pdf-13-HMG20B_HMG20B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4QT-1426-SM-3NMCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85848
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17116
BRD-K43922968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34798
NCI-H2023	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE92965_0_v_1_klf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebellar Purkinje cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.556
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.024
BRD-K35726223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44958
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sarcoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.375818
abnormal inflammatory response	MPO Gene-Phenotype Associations	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18639
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane depolarization during AV node cell action potential	GO Biological Process Annotations 2025	1.0	null
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6928094-395_2019_765_MOESM6_ESM.xlsx-DEGs_AR11_vs_AR7-List_of_differentially_expressed_genes_in_AR11_vs_AR7_Negative_value_means_down-regulation_in_AR11_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.496483
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070714
GTEX-W5WG-2426-SM-4LMI6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26883
Liver hepatocellular carcinoma_LIHC_TCGA-T1-A6J8-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
three	GeneRIF Biological Term Annotations	1.0	null
PMC9461655__F9	PFOCR Pathway Figure Associations 2024	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_7_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980373
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.500398
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Potassium	CTD Gene-Chemical Interactions	1.0	null
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.953526
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
muscle fibre	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.319134
bradycardia	HPO Gene-Disease Associations	1.0	null
hsa-miR-3119	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0126-SM-3NM95	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05053
RT4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94589
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.644884
CatSper complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.449
Pancreatic alpha cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.889
hmc1	HPA Cell Line Gene Expression Profiles	1.0	0.931968
OCIMY5	DepMap CRISPR Gene Dependency	1.0	2.54432
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17582293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64043
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77223
CRCGN008_HEPG2_24H:M20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3097
A673	CCLE Cell Line Gene Expression Profiles	1.0	1.84625
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58166
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05505
MRPS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35939
cefotaxime-5830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13125
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.542
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952361
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.611
GTEX-T6MN-0626-SM-32PM9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92095
Pars compacta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.103
RAD21	ChEA Transcription Factor Targets	1.0	null
Primary dilated cardiomyopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
BRD-K85402309_dovitinib_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52751
BRD-K82206012_S-250_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6984-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24964
BRD-K79355381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01837
TLX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39708
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.988294
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
pyrithyldione-6801	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A56909893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24532
Hyperplasia	CTD Gene-Disease Associations	1.0	1.48838
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266898
Nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.404
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.383637
Glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
NCI-H1876	COSMIC Cell Line Gene Mutation Profiles	1.0	null
G protein-coupled receptor homodimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.924
Selinexor _C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164778
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952757
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039266
CDH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509571
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
GSE166315_5_v_3_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
palmatine-4957	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892116
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
nordihydroguaiaretic acid-6983	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
positive regulation of adipose tissue development	GO Biological Process Annotations 2023	1.0	null
GTEX-Q2AI-1126-SM-48U19	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26626
activator	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4834-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.504
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cardiac	GeneRIF Biological Term Annotations	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.78302
PPARA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483127
increased acute inflammation	MPO Gene-Phenotype Associations	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.02547
HCN channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.263
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.352142
regulation of T cell mediated immunity	GO Biological Process Annotations 2025	1.0	null
SSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00933
GTEX-XGQ4-2626-SM-4AT6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07731
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CLDN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00719328
BRD-K18623962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1652
EW8	DepMap CRISPR Gene Dependency	1.0	4.21103
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.686
Cochlea	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.395
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.854425
MS4A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047293
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08532
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
cell trailing edge	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.258745
ZBTB7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494136
all	GWASdb SNP-Phenotype Associations	1.0	0.029128
BRD-K80761625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04188
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U4B1-1426-SM-4DXTX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37902
GSE134700_0_v_4_ythdf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
KDM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556651
TRP channels	Reactome Pathways 2014	1.0	null
M040416	DepMap CRISPR Gene Dependency	1.0	4.78744
SNUPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0089746
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237211
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57252
H3K9ac_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K62497619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65469
Psoriasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
rostral group of intralaminar nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25559
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3456
membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
hsa-miR-323-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31217
MYC_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10213
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38952
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6088
GMS-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21014
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.7671
BRD-K91018728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6984
BRD-K68433511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82399
heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.23039
PMC9810646-41598_2022_27273_MOESM1_ESM.docx-1-ZNF704_ZNF704	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89040444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48065
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.494
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF3/E2A-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K66453893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40322
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.950817
PKDCC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541282
Glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.138
golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
first	GeneRIF Biological Term Annotations	1.0	null
MYOD1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4485	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
non-hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.163111
ATF1	ENCODE Transcription Factor Targets	1.0	null
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mucolipidosis type IV	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.778
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE86507,GSE86509_3_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal ekg	HPO Gene-Disease Associations	1.0	null
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899321
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1939
COLO-320-HSR	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.15159
BRD-K39863565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66369
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE92965_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Diethylnitrosamine	CTD Gene-Chemical Interactions	1.0	null
LTBR_INHIBITION - 35 Day_GDS2005_732_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.07709
NCIH1781	CCLE Cell Line Gene Expression Profiles	1.0	2.14911
BRD-K49328571_dasatinib_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080067
oleandomycin-5676	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K41504921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44852
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I7-06A-22R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1092	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84192
negative regulation of cell differentiation	GO Biological Process Annotations 2025	1.0	null
ca2+	Phosphosite Textmining Biological Term Annotations	1.0	null
Purkinje myocyte action potential	GO Biological Process Annotations 2025	1.0	null
benzbromarone-5015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
clotrimazole	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Cardiac Purkinje fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.126
protein homotetramerization	GO Biological Process Annotations 2023	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
cation channel activity	GO Molecular Function Annotations 2015	1.0	null
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Respiratory failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.81258
4129_INO80E_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.908484
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863409
Premature Ventricular Contractions	DisGeNET Gene-Phenotype Associations	1.0	null
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.914168
Heart Block	DisGeNET Gene-Disease Associations	1.0	null
cyclopentolate-5734	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Osteochondrodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
Atrioventricular node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.548
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0736
BRD-U82589721_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mpkCCDc14 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.627
GTEX-V955-1726-SM-4JBHF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20588
BRD-K10010414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89127
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CEACAM20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596008
GTEX-XUZC-1326-SM-4BRV2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11106
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
metal ion binding	GO Molecular Function Annotations 2023	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.81059
GTEX-RN64-0126-SM-2TC68	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902244
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YAP1-20516196-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
minoxidil-1496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LNCAP	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
22RV1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.85794
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MMADHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37737
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
SB-202190-6909	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152441,GSE152442_1_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498116
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RM-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIMK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00396629
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980881
BRD-K25600773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34701
Internal carotid artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.313
MAX	ENCODE Transcription Factor Targets	1.0	null
EW-24	GDSC Cell Line Gene Expression Profiles	1.0	1.9063
BRD-K41709602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06415
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
stomach_3b	HPA Tissue Sample Gene Expression Profiles	1.0	0.974419
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UPJH-0926-SM-4IHKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97396
protein homooligomerization	GO Biological Process Annotations 2023	1.0	null
piretanide-6828	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8348042__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Trigeminal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.369
PMC12077394-giaf035_giga-d-24-00380_revision_2.pdf-19-THYN1_THYN1	Rummagene Transcription Factor Associations 2026	1.0	null
Pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.031
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
RUNX1-22412390-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088832
GTEX-WXYG-2326-SM-4E3I6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854155
Lung adenocarcinoma_LUAD_TCGA-75-6214-01A-41R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Sudden infant death syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.616
ASPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047358
mpkCCD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
DKKL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1436
BRD-A82843133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04843
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Astroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.087
IC-86621-7513	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952879
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K37912617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67983
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10512
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
BRD-K03479638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91057
hydrolysis	GeneRIF Biological Term Annotations	1.0	null
BRD-K45307863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53967
BRD-K44779670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4337
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326609
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22378
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.952289
Lung adenocarcinoma_LUAD_TCGA-44-6147-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
calcium activated cation channel activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K13566078_HY-10518_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	1.11186
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10417
BRD-K88573743_A443654_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RUBCNL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00783877
Congenital heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.576
regulation of t cell mediated immunity	GO Biological Process Annotations 2015	1.0	null
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lake et al.Science.Ex8_Brain_Human	CellMarker Gene-Cell Type Associations	1.0	null
SEMA3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00649265
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ESRRB-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81418486_vorinostat_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
Potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.033
PRC2_EZH2_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
nuclear part	GO Cellular Component Annotations 2015	1.0	null
Sodium	CTD Gene-Chemical Interactions	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
believed	GeneRIF Biological Term Annotations	1.0	null
PIP4K2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047856
HCC2429	DepMap CRISPR Gene Dependency	1.0	3.91812
BRD-K73678117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82288
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6672
fenoprofen-3412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242454
EW-3	GDSC Cell Line Gene Expression Profiles	1.0	2.21422
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
GSE108675_2_v_1_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	1.11001
Pars recta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
Prostate cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.548
PSMA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47508
autosomaldominant	GeneRIF Biological Term Annotations	1.0	null
BRD-K99873441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.31035
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.830345
BRD-K08558441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51443
sodium ion transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
0317956-0000-4331	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.938
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.993131
HSC-T6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
transporter activity	GO Molecular Function Annotations 2015	1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3805
LBA	DGIdb Drug Targets 2026	1.0	3.11365
MBNL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00766299
ATP5F1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03247
Intracellular signaling and cell migration supercomplex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
SETDB1-19884255-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049011
PMC7078078__F1	PFOCR Pathway Figure Associations 2024	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.54929
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51045
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.71884
Hydrocephalus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FLT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523057
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
GSE140200_1_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
17597811-SuppTable7	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XAJ8-1426-SM-47JYM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932823
Ec	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.062
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34083
EZH2_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05147
ESRRB-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H250	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
reduction	GeneRIF Biological Term Annotations	1.0	null
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1195	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04355
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.938086
SC-560-6913	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K91397206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8406
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4722-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF4G	ENCODE Transcription Factor Targets	1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
myotonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.188022
Muscularis mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06955
6874_PSMD6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.514071
BRD-K02558072_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
production	GeneRIF Biological Term Annotations	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950738
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.44839
GABA-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.057
PMC2743935__F5	PFOCR Pathway Figure Associations 2024	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
attenuated	GeneRIF Biological Term Annotations	1.0	null
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
regulation of cardiac muscle cell contraction	GO Biological Process Annotations 2023	1.0	null
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K08715020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49725
BRD-K29652917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03763
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.850407
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreatic beta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276846
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01827055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16935
Arterial endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.17491
PF-00562151-00-6912	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CEP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94155
insulin	GeneRIF Biological Term Annotations	1.0	null
9506_UBE2I_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.598192
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9085
positive regulation of canonical Wnt signaling pathway	GO Biological Process Annotations 2025	1.0	null
Atherosclerosis_Aorta Smooth Muscle Tissue_GSE1560	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.46508
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
CRCGN013_HEPG2_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35638
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6237
WT1-20215353-NEPHRON-PROGENITOR-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-1226-SM-4BOPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07216
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69092
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059898
BRD-K07489121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05686
6747_PRIM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.618457
decreased hematopoietic cell number	MPO Gene-Phenotype Associations	1.0	null
BRD-K60828476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06581
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9169
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.850344
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00995
Rootlet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
LIVF001-015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02097
PROZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00325924
etacrynic acid-5742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RERF-LC-MS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.445
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01165
ZNF106	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02285
GTEX-WYJK-0126-SM-3NMAB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829774
BRD-K44100512_KIN001-043_SKBR3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_5409_KD_PLZF_SRP136521	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.91556
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15889
BRD-K89801935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18833
BTP2	DGIdb Drug Targets 2026	1.0	1.03788
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34525
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.183935
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042491
NCI H322M	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
catsper complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.629465
BRD-A55574211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32229
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06407
GTEX-T6MN-0726-SM-32PML	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951779
SCC-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0398
Pancreatic islet cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.972
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sodium ion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
positive regulation of wnt signaling pathway	GO Biological Process Annotations 2015	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
system	GeneRIF Biological Term Annotations	1.0	null
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.853571
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.64618
GTEX-OHPM-1426-SM-3TW8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48849
PMC7260947-pnas.1912355117.sd02.xlsx-Sheet1-1185_common_genes_in_D_E_genes_KD_and_AcAPE1_ACOGG1_G4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
peptidyl-lysine modification	GO Biological Process Annotations 2015	1.0	null
APOE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00434517
GTEX-S4P3-1226-SM-4AD4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8523
496100319_HIP_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.00058
negative regulation of osteoblast differentiation	GO Biological Process Annotations 2025	1.0	null
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
NCAPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42911
11-deoxy-16,16-dimethylprostaglandin E2-7514	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S95S-1226-SM-4GICG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830338
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06935
2307_DNASE1L1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.692059
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9362915-pone.0272017.s004.xlsx-Day5_-0_7_Top-BBX_BBX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69241192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08065
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Cardiomyocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.361
rt4	HPA Cell Line Gene Expression Profiles	1.0	1.24205
PMC6689252__F6	PFOCR Pathway Figure Associations 2024	1.0	null
2186_DHDDS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06508
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.74425
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLFN11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00748461
Choroid plexus epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.907
OSRC2_KIDNEY	CCLE Cell Line Proteomics	1.0	11.6308
GSE165682_0_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of heart rate	GO Biological Process Annotations 2023	1.0	null
CACNG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568301
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
external male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.102799
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11448
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15013
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061941
GTEX-XGQ4-1326-SM-4GIDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33991
Golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-U3ZN-2026-SM-4DXUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.073
GSE210580_5_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835215
Respiratory Failure	DisGeNET Gene-Disease Associations	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
YES1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476048
intracellular signaling cassette	GO Biological Process Annotations 2025	1.0	null
pontine nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02276
BRD-K74963702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35048
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21191
BRD-K45589340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07714
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079906
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694536
GSE238018_3_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K51196703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35825
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01549	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.913707
cellular process	GO Biological Process Annotations 2015	1.0	null
Taste bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.897
Adenocarcinoma of lung_Lung Tissue_GSE11969	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.47146
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiac Arrest	DisGeNET Gene-Disease Associations	1.0	null
BNC1_KD_GDS1978_738_mouse_Oocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J1-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.63269
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8295
CREB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00136
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.40822
MDM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00701376
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02130563_S1030_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7912581__F8	PFOCR Pathway Figure Associations 2023	1.0	null
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05375
Prestwick-674-3716	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
Reticulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.259
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.876941
GTEX-S4UY-1626-SM-4AD55	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14453
NCIH2452	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55284
Astrocyte projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.355
BRD-K24496482_SB590885_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-ZNF257_ZNF257	Rummagene Transcription Factor Associations 2026	1.0	null
SKNMC	CCLE Cell Line Gene Expression Profiles	1.0	2.75274
BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_SKM1_6.0_h_6.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
Cerebrovascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.93
AP3D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00965866
8633_SYS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551561
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
protein sumoylation	GO Biological Process Annotations 2015	1.0	null
aortic smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.178224
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of osteoblast differentiation	GO Biological Process Annotations 2025	1.0	null
PMC11727256-ADVS-12-2404491-s003.xlsx-Sheet1-ZNF286A_ZNF286A	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-1126-SM-48TZY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63855
Saphenous vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.605
calcium ion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HRH4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00791803
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.965879
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.861442
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
RH-1	GDSC Cell Line Gene Expression Profiles	1.0	1.89383
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cutaneous Plaque	DisGeNET Gene-Phenotype Associations	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05709
Polycystin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.25
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trimetazidine-2876	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A67788537_Salermide_RMUGS_6.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0042731
Cation channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.352
PK59	CCLE Cell Line Gene CNV Profiles	1.0	1.98863
PHA-00846566E-7046	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.576
BRD-K37680172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07204
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Distal axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.625
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986213
Pamidronic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
HEL9217	DepMap CRISPR Gene Dependency	1.0	2.9253
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2176
increased vascular permeability	MPO Gene-Phenotype Associations	1.0	null
calcium channel activity	GO Molecular Function Annotations 2015	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34746
RBCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551574
hexestrol-6077	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE103068_5_v_8_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.991662
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dental follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.089
Apical plasma membrane urothelial plaque	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.575
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11538
EN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76871
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I0-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of cardiovascular system physiology	HPO Gene-Disease Associations	1.0	null
SOCS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0043507
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
calcium ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Perturb_1606_KO_Tnfaip3_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.16082
Hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.756
PACSIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620707
LRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600231
Phosphatidylinositol 4,5-Diphosphate	CTD Gene-Chemical Interactions	1.0	null
PIP<sub>2</sub>	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
KS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.868084
gallamine triethiodide-2059	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NB13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.92964
Lung adenocarcinoma_LUAD_TCGA-86-8279-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47618355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35029
mIMCD-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.719
PRKCA	Hub Proteins Protein-Protein Interactions	1.0	null
GTEX-TMZS-0126-SM-3DB9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964405
Pia mater	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.57
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
player	GeneRIF Biological Term Annotations	1.0	null
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	1.0	3.04507
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
NKRF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509009
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.9029
GTEX-SNMC-0926-SM-4DM5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58194
PMC6487024-13148_2019_658_MOESM2_ESM.xlsx-S4-ADNP-2_DMRs-Unnamed_11_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
EoL-1-cell	GDSC Cell Line Gene Expression Profiles	1.0	1.64583
chr19_49148533_G_A_b38	GTEx eQTL 2025	1.0	2.53224
HOXA9_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Immunodeficiency 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
GTEX-QV44-1926-SM-2S1RF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879253
calcium ion transport	GO Biological Process Annotations 2015	1.0	null
GSE200839,GSE233826_3_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-g-Classification_of_camel_SON_basal_genes_-_ion_channels_SON	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14528_KO_Gata4_SRP111204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.1363
Polygenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPP1R13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18555
MLN 8237	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
meclozine-5244	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093187
PRDX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00738128
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.802
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
dental follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.351856
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.17576
GTEX-XYKS-1426-SM-4BRUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0399
BRD-K31672963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4866
Progressive Familial Heart Block, Type Ib	CTD Gene-Disease Associations	1.0	2.88009
Perturb_1434_KO_Kmt2c_SRP283007	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.61661
bephenium hydroxynaphthoate-5628	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.906386
ROGDI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28944
decamethonium bromide-4094	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SETDB1_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.779
ozagrel-5983	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE233679_14_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
6875_PSMD7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.980029
GTEX-P44H-0726-SM-48TBT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965306
UMUC14	DepMap CRISPR Gene Dependency	1.0	2.4624
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228234
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07034
outer CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24189
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069484
BRD-K83833383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40975
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.37987
GSE147876,GSE147877_2_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154942
etanidazole-5730	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
T84	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.09639
Sarcoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.247
PANC0327	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.42294
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.829975
PRDM14_01_45	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59351
A7r5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.63
BRD-K69817695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26407
NECTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04976
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212761
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08125
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
GSE255680_1_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.903
First Degree Atrioventricular Block	DisGeNET Gene-Disease Associations	1.0	null
membrane depolarization during bundle of His cell action potential	GO Biological Process Annotations 2023	1.0	null
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28624
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22421
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
8416_SRP68_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.883749
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW-16	GDSC Cell Line Gene Expression Profiles	1.0	2.70944
BRD-K96945247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14203
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00698
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SBNO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09744
Basophilic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.801
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
SW1990	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.00768
BRD-K04546108_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
T3M3	DepMap CRISPR Gene Dependency	1.0	3.74801
GSE143643,GSE143644_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN010_HEPG2_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37328
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.828082
regulation of cell population proliferation	GO Biological Process Annotations 2023	1.0	null
SEMA6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01575
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.619255
tocainide-7351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-O5YT-0126-SM-48TBW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89845
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11857_KO_miR301a_SRP131007	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.26982
Cell trailing edge	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.945
Z disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.015
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.85624
E2F6	ENCODE Transcription Factor Targets	1.0	null
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
downstream	GeneRIF Biological Term Annotations	1.0	null
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Extrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8245133__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
pathways	GeneRIF Biological Term Annotations	1.0	null
BRD-A28105619_curcubitacin I_SNUC4_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.98932
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A85H-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol-1633	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.66758
Spinal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.599
light-harvesting complex, core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.577
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.802
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ciprofloxacin-1522	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Left ventricular noncompaction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.641
pizotifen-6513	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70073
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6510-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.981341
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918274
GSE164874_5_v_8_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.508
RPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99226
Polycystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.88
GSE153923_1_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06286
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43888
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K63107801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00707
BRD-K57472585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21195
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.888386
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A3-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.727741
BRD-K50474387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29153
GTEX-XUZC-1426-SM-4BRV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56492
Choanomastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
glucagon	GeneRIF Biological Term Annotations	1.0	null
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Porcine aortic endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.773
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15924
6-bromoindirubin-3'-oxime-7101	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K10157835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70725
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	124.472
phenazopyridine-6100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
C32	Achilles Cell Line Gene Essentiality Profiles	1.0	1.52228
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
corbadrine-7208	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.869106
ankyrin-B-related cardiac arrhythmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.801177
abnormal hematopoietic system morphology/development	MPO Gene-Phenotype Associations	1.0	null
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42918627_GSK-2126458_SKBR3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pravastatin-lactone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40428
BRD-K59182232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37527
serotonin-activated cation-selective channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.697
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
SLC38A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0084844
monocrotaline-6771	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
magnocellular (medial) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.887338
DT-40 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
ion channel activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89143
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01173
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protriptyline-5438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE246461,GSE246463_5_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-199b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.54
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
monoatomic cation channel activity	GO Molecular Function Annotations 2025	1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
Vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.346
Mast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.704
inner ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.188151
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24659
molt4	HPA Cell Line Gene Expression Profiles	-1.0	-1.22248
HM-1 ES cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
karakoline-6059	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of adipose tissue development	GO Biological Process Annotations 2025	1.0	null
SKBR3	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.857325
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.029157
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.861442
regulation of canonical Wnt signaling pathway	GO Biological Process Annotations 2025	1.0	null
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.935155
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1671
Hepatobiliary carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.748
Substantia nigra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.362
GTEX-UPIC-1726-SM-4IHKG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32722
major	GeneRIF Biological Term Annotations	1.0	null
Cardiofibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.44
BRD-K98061177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01532
JURKAT	DepMap CRISPR Gene Dependency	1.0	3.27804
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10697
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.908924
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.06191
BRD-K54042694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13795
BRD-K04923131_3194_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12513837-41588_2025_2336_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_List_of_AR-only_and_p300_AR-shared_enhancer_regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23782109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93118
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sensory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.51335
Aorta thoracica smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.506
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16631
Neuron projection terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.721
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SMARCA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661871
BRD-K18856772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31621
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57021
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14875
prostate	GTEx Tissue Gene Expression Profiles	1.0	1.08932
4935_MED14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.576175
hsa-miR-4753-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
icSARA deltaORF6_60Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.49603
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243852
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14111
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37254228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76214
dexamethasone_rattus norvegicus_gpl1355_gse29912	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
NT5E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00762521
mode of inheritance	HPO Gene-Disease Associations	1.0	null
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
8332_SPC25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613136
Brain Lower Grade Glioma_LGG_TCGA-S9-A6UA-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brugada syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.863
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inorganic cation import across plasma membrane	GO Biological Process Annotations 2023	1.0	null
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21093
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24184
SLC7A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492326
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181749_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08528
a7r5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.325701
LS-174T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.663
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.945995
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03862
GSE133516_5_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
divalent inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_id_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30964167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8953
c19ga	GeneRIF Biological Term Annotations	1.0	null
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32107
calcium ion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
RNF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8278
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.40064
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.857266
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
cardiac conduction	GO Biological Process Annotations 2015	1.0	null
HEK-293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.042
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOTO-0126-SM-4B66N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906613
GSE173262_2_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WH7G-1726-SM-4LVKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26746
pedigree	GeneRIF Biological Term Annotations	1.0	null
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81312
A253	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55175
TRIM28	ENCODE Transcription Factor Targets	1.0	null
GTEX-XQ3S-1526-SM-4BOOC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16041
trichostatin A-3332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCIMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492278
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.997
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Jugular vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38633
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC10534007-Table_2.xlsx-S3_unique_up_MSC_V-817_elements_included_exclusively_in_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3369_GINS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.71683
Status Epilepticus	DisGeNET Gene-Disease Associations	1.0	null
TMEM82	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573985
BRD-K73768826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12311
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.31613
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.890971
divalent	GeneRIF Biological Term Annotations	1.0	null
membrane depolarization during AV node cell action potential	GO Biological Process Annotations 2023	1.0	null
Proximal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.142
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.975441
CAMKK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493672
TTC709	DepMap CRISPR Gene Dependency	1.0	2.44678
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
16288205-GeneTable3	GeneSigDB Published Gene Signatures	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
Tongue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.687
BRD-K71093375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12454
Perisynaptic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.772
Mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.95
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210580_5_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
abnormal immune system cell morphology	MPO Gene-Phenotype Associations	1.0	null
ion gated channel activity	GO Molecular Function Annotations 2015	1.0	null
Uterine adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
PMC12077394-giaf035_giga-d-24-00380_original_submission.pdf-17-THYN1_THYN1	Rummagene Transcription Factor Associations 2026	1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.890971
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35258
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.89465
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K33462260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34996
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.845659
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81567
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain edema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.398
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane depolarization during bundle of His cell action potential	GO Biological Process Annotations 2025	1.0	null
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF391	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00835695
BRD-K88679075_methylandrostenediol_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NALM16	DepMap CRISPR Gene Dependency	1.0	2.99404
regulation of cell population proliferation	GO Biological Process Annotations 2025	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Left Ventricular Hypertrophy	DisGeNET Gene-Disease Associations	1.0	null
BRD-K96254487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02858
GSE256181_2_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Basal plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.868
sirolimus-5239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN013_HEPG2_24H:H21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20823
BRD-K32595757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03229
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86324
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5581-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MG-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56126872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65374
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S18-Table_S18_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-002_4H_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
terguride-6299	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Septum pellucidum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
GSE210580_0_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Renal artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.878
parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.797291
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.883185
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
generated	GeneRIF Biological Term Annotations	1.0	null
muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.324094
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K98404142_16beta-Bromoandrosterone_VCAP_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE233679_12_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prolonged Qt Interval	DisGeNET Gene-Phenotype Associations	1.0	null
plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K67844266_MLN4924_VCAP_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Myenteric plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
BRD-K58324650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16399
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36035
identify	GeneRIF Biological Term Annotations	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-QM-A5NM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
minoxidil-4800	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K72441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36786
KM-H2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Gap junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.489
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ES-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YMB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53559
Perturb_8039_KD_LIX1L_SRP202079	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.08603
hsa-miR-3679-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.80086
Long QT syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
Glossopharyngeal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.926
Progressive familial heart block type IB	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.003
SMARCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30124
Anterior horn	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38877
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-1726-SM-3NB16	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77305
positive regulation of fat cell differentiation	GO Biological Process Annotations 2025	1.0	null
H3K9me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AN3CA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
SAP30	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZM-1126-SM-4DXUB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04908
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
WT1-19549856-CCG9911-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K08715918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62231
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTSE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00698711
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.759758
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-1526-SM-3P61M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25593
endoplasmic reticulum	GO Cellular Component Annotations 2015	1.0	null
BRD-K07460436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34218
regulation of fat cell differentiation	GO Biological Process Annotations 2023	1.0	null
BRD-K84457681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43657
GSE137702_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cation channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69867
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8041-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04325154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65761
availability	GeneRIF Biological Term Annotations	1.0	null
Perturb_7198_KD_ICE1_SRP164752	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.626
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EB-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.112
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21261
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of T cell mediated immunity	GO Biological Process Annotations 2023	1.0	null
regulation of adipose tissue development	GO Biological Process Annotations 2023	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.958105
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.85807
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
NFYA_01_288	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59342
NDUFA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13313
GTEX-XQ3S-1426-SM-4BOPR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03841
HS 675.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12654
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386054
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.467273
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.836555
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.842704
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JO-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K82143716_5-fluorocytosine_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Diseases	CTD Gene-Disease Associations	1.0	1.10699
TSPAN7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066784
BRD-A38425832_NCGC00229596-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6847_PSMA7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562025
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
ABL127	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
regulation of ventricular cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
Inward rectifying potassium channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.933
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
imipramine-1807	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mephentermine-4707	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-2026-SM-4DM6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6646
LCLC97TM1	DepMap CRISPR Gene Dependency	1.0	4.22976
Dentin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.754
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889414
peptidyl-lysine modification	GO Biological Process Annotations 2025	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36099
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.095
NCIN87	CCLE Cell Line Gene CNV Profiles	1.0	1.55742
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34746
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
AUTS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622718
GSE241031_0_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of cell differentiation	GO Biological Process Annotations 2023	1.0	null
BRD-K61316494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31975
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Renal medulla cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.866
Leptomeninx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.787
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02947
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20705
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.86529
ursolic acid-2067	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Stimuli-sensing channels	Reactome Pathways 2014	1.0	null
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FAM13A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609255
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
congenital heart block	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.419892
regulation of signaling	GO Biological Process Annotations 2015	1.0	null
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	2.52289
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.689
GTEX-XQ3S-2526-SM-4BOOG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47853
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Differentially_expressed_genes_of_RORC_cluster_RORgt_DC_compared_to_other_clusters_in_each_dataset_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A85860691_chaetocin_EFO27_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
CRCGN014_HEPG2_3H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15619
NTRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521635
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91771
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13235
Main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.125
BRD-K84593579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.053
PRKCA	Pathway Commons Protein-Protein Interactions	1.0	null
olfactory bulb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.188529
BRD-K06147970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57122
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HO-1-u-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.87366
sirolimus-6927	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
signals	GeneRIF Biological Term Annotations	1.0	null
lead	GeneRIF Biological Term Annotations	1.0	null
PMC2743935__F5	PFOCR Pathway Figure Associations 2023	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A538-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spiral organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.263327
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.2137
QKI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555757
PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE181749_2_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
9-PHENANTHROL	DGIdb Drug Targets 2026	1.0	3.11365
WDR87	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060889
GSE239844_4_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNMC-1126-SM-4DM5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03287
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-2.04237
antazoline-6775	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cation-transporting ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.256
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852006
TC-N 22A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
NCIH2291_LUNG	CCLE Cell Line Proteomics	1.0	2.98274
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.79
requires	GeneRIF Biological Term Annotations	1.0	null
bone marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079592
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.77568
WT1-20215353-NEPHRON PROGENITOR-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
chloropyrazine-5750	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6033-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE235644_1_v_0_fasn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRC1_BMI_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
PMC3012182__F1	PFOCR Pathway Figure Associations 2023	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.610943
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.985471
regulation of vasoconstriction	GO Biological Process Annotations 2023	1.0	null
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
due	GeneRIF Biological Term Annotations	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
DROSHA-22980978-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Brain capillary endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.532
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.6174
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Inward rectifier potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.85
lateral hypothalamic area, anterior part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.85248
Acute Myeloid Leukemia_LAML_TCGA-AB-2861-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spironolactone-2064	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8ID-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.08369
GTEX-RWSA-2026-SM-47JX8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54323
CEBPD	ENCODE Transcription Factor Targets	1.0	null
Somatoform disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.14058
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42375
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67099
NCIH2126	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
depudecin-874	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.1395
BRD-K02708799_GSK-1059615_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VEGFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4993
BRD-M86331534_BJM-ctd2-9_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE204784,GSE204787_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of osteoblast differentiation	GO Biological Process Annotations 2023	1.0	null
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
modulates	GeneRIF Biological Term Annotations	1.0	null
Dental pulp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.036
protein homooligomerization	GO Biological Process Annotations 2025	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98451611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00055
MCF7_Alisertib_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132284
CRCGN011_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68615
Bulb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36549
GSE138001_0_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18566
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.494585
diazoxide-2052	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pons	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
Conduction system disorder	ClinVar Gene-Phenotype Associations 2025	1.0	null
substrate-specific channel activity	GO Molecular Function Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1455_CDR2L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511765
Lung adenocarcinoma_LUAD_TCGA-97-8177-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glipizide-4991	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.481
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
eight	GeneRIF Biological Term Annotations	1.0	null
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr19_49163316_C_T_b38	GTEx eQTL 2025	1.0	1.3847
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.466
taxis	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-8640-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.945399
Collecting duct cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
GSE186647,GSE217288_2_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.3756
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.73954
experimental	GeneRIF Biological Term Annotations	1.0	null
peripheral nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.401386
TE9	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.88992
isoetarine-7170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Gas vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
hsa-miR-3922-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ACO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00387163
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.871
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220693_1_v_0_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LNPEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00482478
Cytosolic region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.458
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pi45p2	GeneRIF Biological Term Annotations	1.0	null
sarcoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.406361
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.260931
APOBEC3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00777137
Vascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.708
GTEX-TML8-1926-SM-32QOS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924163
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
GTEX-XMK1-1026-SM-4B65H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40673
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078588
nadide-6091	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QDVN-1326-SM-48TZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34767
huh-7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.952068
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22541
SW620	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K15867859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61376
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3311
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CENPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72022
BRD-K49865102_PD-0325901_HT29_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EW-12	GDSC Cell Line Gene Expression Profiles	1.0	1.44234
2262_DMRTC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.22597
branches	GeneRIF Biological Term Annotations	1.0	null
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
naltrindole-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51175
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07193
implicate	GeneRIF Biological Term Annotations	1.0	null
P2URK562	DepMap CRISPR Gene Dependency	1.0	3.07884
Anemia	CTD Gene-Disease Associations	1.0	1.03235
CLCF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059198
6843_PSMA3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.679329
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
5211181-950	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00589
benzthiazide-4952	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
regulation of atrial cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046157
Tumor Necrosis	DisGeNET Gene-Phenotype Associations	1.0	null
familial	GeneRIF Biological Term Annotations	1.0	null
GTEX-RNOR-0126-SM-2TF57	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942133
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
prostate gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Stereocilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.81
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7415-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.514
ZNF384	ENCODE Transcription Factor Targets	1.0	null
EPHB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0046349
Chronic fatigue syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.596596
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.3266
KCNE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23768
MHHES1	CCLE Cell Line Gene Expression Profiles	1.0	1.53252
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053471
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44407
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81S-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.212
9972_ZBTB16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.60891
USF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K65506286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35589
BRD-K29441085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99958
Wolff-Parkinson-White pattern	ClinVar Gene-Phenotype Associations 2025	1.0	null
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.22884
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.99322
BRD-K74881104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95879
SKBR3	CCLE Cell Line Gene Expression Profiles	1.0	1.99237
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Syntrophin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.249
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCS ERK 11e	DeepCoverMOA Drug Mechanisms of Action	1.0	1.08
metamizole sodium-3929	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NA-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_TCFCP2L1_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K57184137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0326
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.913811
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
benzethonium chloride-7207	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
benzamil-6056	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
1771_COPB1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.686681
calcium ion binding	GO Molecular Function Annotations 2023	1.0	null
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76455
Orthogonal array	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.392
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38267
BTBD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005835
Astrocyte end-foot	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.159
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.722079
Perturb_8779_Mut_SMARCB1_SRP223162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.5948
doxycycline-5838	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94832621_Y 134_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941299
Combined immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
A4-Fuk	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.10902
Outer hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U343	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.17671
SNU620	CCLE Cell Line Gene CNV Profiles	1.0	1.34828
BRD-K99119142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8172
prazosin-6475	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67902591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52668
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
glycopyrronium bromide-3427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
decavanadate	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44091
COS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.441
Ileum smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
Cerebral infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
15-delta prostaglandin J2-6990	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ADORA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599828
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCILY19	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45818
properties	GeneRIF Biological Term Annotations	1.0	null
Pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.198
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.938637
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
eGFP-HDAC8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
establishment of localization	GO Biological Process Annotations 2015	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K46120925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21717
nicergoline-2220	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
site	GeneRIF Biological Term Annotations	1.0	null
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.131568
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
Coronary artery endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.716
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dioctanoyl-phosphatidylinositol 4,5-bisphosphate	CTD Gene-Chemical Interactions	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949491
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-2726-SM-4JBH9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07631
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25832
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.1395
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Prostate gland epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
GTEX-XYKS-2126-SM-4E3IB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973657
GTEX-PX3G-1426-SM-48U1J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40495
BRD-K06344882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29524
GTEX-OIZH-1426-SM-3NB1O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67423
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
GTEX-XUJ4-1326-SM-4BOQ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881802
DDR1_knockdown_169_GSE39207	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.79749
Large_Intestine-intestinal crypt stem cell	Tabula Sapiens Gene-Cell Associations	1.0	0.303467
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30138
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Dura mater	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.865
GSE211262,GSE211263_0_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
cell chemotaxis	GO Biological Process Annotations 2015	1.0	null
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H250	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A50M-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-A59Q-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07366
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
Kna	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.949
TEAD4	ChEA Transcription Factor Targets	1.0	null
GTEX-WFG7-1826-SM-3GIL1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2267
aminophenazone-2060	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1963	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K10467831_tibolone_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD3-2326-SM-4AT5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874081
Renal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.238
Perturb_1997_KO_Arid1b_SRP344792	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.14583
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
4622_LMX1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.524925
tongue epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.525955
C3orf38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2842
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993098
GTEX-XUZC-1626-SM-4BRVP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40989
NR2C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540698
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS683	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78924
Congestive heart failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.983
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94179
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04591
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.027
B4GALT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00448756
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.10239
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19394
difenidol-7406	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWO3-1526-SM-48TCM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997376
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.7107
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948304
OF-47-EQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218261
Pulmonary artery endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.618
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32507
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Encephalomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.749
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.813
RUSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71836
GSE102675_2_v_1_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cdx2_21074721_jejunum_epithelium_lof_mouse_gpl10773_gse23436	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.03252
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of cell differentiation	GO Biological Process Annotations 2023	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52099
BRD-K24883912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59114
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13257
tretinoin-966	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P78B-1726-SM-3P5ZV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26844
H3K27me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114272_0_v_1_clk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC5035084-pone.0163362.s004.docx-0-SNP_within_frequency_range_1_1000-1_10000_MAF_0_1-0_01_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836633
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31069
MCF7	Achilles Cell Line Gene Essentiality Profiles	1.0	1.54971
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.56403
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.805
S117	DepMap CRISPR Gene Dependency	1.0	4.77956
PRPF40A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16731
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37527826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05525
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE122067_3_v_0_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
heart block	HPO Gene-Disease Associations	1.0	null
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.001
outer CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.851322
BRD-K65597286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1868
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.703536
8417_SRP72_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599343
calcium	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K00789767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01485
cardiovascular system phenotype	MPO Gene-Phenotype Associations	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0339
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10491
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colon muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.584422
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-1826-SM-4DM7F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17815
BRD-K99451608_L469480_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE147876,GSE147877_4_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
alpha-TC1.6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
BRD-A94570195_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZR75_1	BioGPS Cell Line Gene Expression Profiles	1.0	0.982142
TFCP2L1	ChEA Transcription Factor Targets	1.0	null
BRD-K77345736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34213
cations	GeneRIF Biological Term Annotations	1.0	null
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.981341
Pancreatic adenocarcinoma_PAAD_TCGA-F2-A8YN-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
probands	GeneRIF Biological Term Annotations	1.0	null
positive regulation of adipose tissue development	GO Biological Process Annotations 2025	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.855526
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35353
ARID3A	ENCODE Transcription Factor Targets	1.0	null
u251mg	HPA Cell Line Gene Expression Profiles	-1.0	-1.00418
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.33724
cellular_component	GO Cellular Component Annotations 2015	1.0	null
GTEX-R55G-1226-SM-48FDC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22646
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905504
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207433_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233503
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.910698
GLP1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00449466
GSE174498,GSE174500_5_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130715_2_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZC3HAV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74214
decreased dendritic cell number	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40403
gastrointestinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.492182
aorta thoracica smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233731
Perturb_3990_KD_Zeb1_ERP109420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.61719
7753_SEC61G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0612
SW1271	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
SK-NEP-1	GDSC Cell Line Gene Expression Profiles	1.0	1.73182
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046143
BRD-K52080565_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SW620_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.87962
positive regulation of multicellular organismal process	GO Biological Process Annotations 2023	1.0	null
BOP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660024
STK32C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604608
Encephalomyelitis	DisGeNET Gene-Disease Associations	1.0	null
regulation of insulin secretion involved in cellular response to glucose stimulus	GO Biological Process Annotations 2025	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28378
CSNK2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741319
BRD-K64173373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19209
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	246.249
GTEX-POMQ-0826-SM-3P61H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06437
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01254
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11876530-3214633.f4.pdf-118-ZNF404_ZNF404	Rummagene Transcription Factor Associations 2026	1.0	null
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21826
SETDB1	ENCODE Transcription Factor Targets	1.0	null
ovary	HPA Tissue Gene Expression Profiles	-1.0	-1.06868
BRD-A29901043_KIN001-127_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3L7-01A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12616242-can-24-3452_supplementary_table_s4_suppst4.xlsx-EWSR1FLI-KDM6A_genes-Genes_associated_to_EWSR1_FLI1-KDM6A_peaks_in_A-673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72029544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51723
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69932463_AZD8055_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79376287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38454
Bradycardia	DisGeNET Gene-Phenotype Associations	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE223334_1_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
butyl hydroxybenzoate-5245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K31805261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.25719
required	GeneRIF Biological Term Annotations	1.0	null
BRD-A94793051_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prazosin-6315	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K92749855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15556
7893_SEM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.13345
GTEX-QMRM-1226-SM-447C6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37143
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
sodium:potassium-exchanging ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.279
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
phenotypic abnormality	HPO Gene-Disease Associations	1.0	null
cardiac muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.754537
currents	GeneRIF Biological Term Annotations	1.0	null
Atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.311
BRD-K72892670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35067
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0954
ZHX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00931223
general	GeneRIF Biological Term Annotations	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.00103
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02763
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41410256_balsalazide_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XV7Q-1326-SM-4BRWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05621
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11235
atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.61578
GTEX-WY7C-2326-SM-3NB2U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92698
IDO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511019
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84088
Aortic body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.972
NCIH1339	CCLE Cell Line Gene CNV Profiles	1.0	1.53361
COG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53438
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77829
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MR-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JSRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572493
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
perhaps	GeneRIF Biological Term Annotations	1.0	null
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
8517_STK24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553284
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF4	ChEA Transcription Factor Targets	1.0	null
BRD-K99847716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7867
SK-MEL-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
GTEX-WYBS-0926-SM-3NM94	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902453
GTEX-U3ZN-1226-SM-4DXUD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921012
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20389
Lung squamous cell carcinoma_LUSC_TCGA-56-8307-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trachea	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07717
Perturb_11459_KO_Ezh2/Jak2_SRP075923	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.66829
BRD-K63111122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61797
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tongue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.472704
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848766
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
tooth germ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121132
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pulmonary hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
peptidyl-lysine modification	GO Biological Process Annotations 2023	1.0	null
CP-645525-01-7515	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.198
Microvascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.62
hascs	GeneRIF Biological Term Annotations	1.0	null
LTBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00856034
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.93313
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DN-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF792	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58461
BRD-K35792251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00699
hsa-miR-4314	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
CRCGN011_HEPG2_24H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22755
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Proteinuria	CTD Gene-Disease Associations	1.0	1.16203
GTEX-NFK9-2226-SM-3MJGP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63228
Leaflet of membrane bilayer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11659
CEACAM19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569015
Aortic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
Perturb_16092_KD_RRM2_SRP398748	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.61191
calcium-mediated signaling	GO Biological Process Annotations 2023	1.0	null
Muscle fibre	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.094
Uroepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.298
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07919
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-1226-SM-48TZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66549
2,6-dimethylpiperidine-3806	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
duchenne muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.399334
Supraoptic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
positive regulation of heart contraction	GO Biological Process Annotations 2025	1.0	null
BRD-K29338816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.99703
GTEX-S4UY-0826-SM-4AD4Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08331
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26795
nucleus coeruleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51752
MCF7_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0093921
ZPBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060487
Agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.12391
2233_DIS3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58381
Brain Lower Grade Glioma_LGG_TCGA-DU-5854-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSPA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16443
chlorphenamine-6773	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
P30-OHK	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43745
CRCGN015_MCF10A.TP53.M_24H:F09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1157
KBTBD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00827252
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dendritic cell migration	GO Biological Process Annotations 2025	1.0	null
accessory olfactory bulb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.431843
BRD-A24524033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08579
BRD-A89681034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75105
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
dinoprostone-6590	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	2.15801
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A62995832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77797
dystrophin-associated glycoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.095
dendritic cell migration	GO Biological Process Annotations 2015	1.0	null
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14111
hsa-miR-4302	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
BRD-A75409952_wortmannin_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorzolamide-5785	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sodium ion import across plasma membrane	GO Biological Process Annotations 2025	1.0	null
troglitazone-6991	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TCF12_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KPT-330	DeepCoverMOA Drug Mechanisms of Action	1.0	1.16
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18482
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.78919
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
17597811-SuppTable9	GeneSigDB Published Gene Signatures	1.0	null
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18059
BRD-A77907596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02962
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC3A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558377
TRIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06671
Ventral globus pallidus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
IGF2BP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00366733
XRN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712651
betahistine-6611	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
voltage-gated sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.567
1504_CEP350_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630216
BRD-K29301364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21723
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
BRD-A76528577_Vincristine sulfate_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
beta-catenin destruction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.946
clear	GeneRIF Biological Term Annotations	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.877228
Perturb_14972_KO_Max_SRP225905	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.1098
SUM1315MO2	DepMap CRISPR Gene Dependency	1.0	3.00467
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.379
TCF3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Catecholaminergic polymorphic ventricular tachycardia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.081
immune system phenotype	MPO Gene-Phenotype Associations	1.0	null
Left bundle branch hemiblock	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
MZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.837581
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.965839
Subarachnoid Hemorrhage	DisGeNET Gene-Disease Associations	1.0	null
GTEX-R53T-1326-SM-48FCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5454
MCF7_Lomustine_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161649
TASK1	DepMap CRISPR Gene Dependency	1.0	7.06614
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.22
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20961
abnormal cell-mediated immunity	MPO Gene-Phenotype Associations	1.0	null
PMC4312948__F7	PFOCR Pathway Figure Associations 2024	1.0	null
GSE160373_5_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RN64-0726-SM-48FCV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838489
NCCSTCK140	CCLE Cell Line Gene CNV Profiles	1.0	1.75437
GTEX-RN64-1226-SM-2TC6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896385
GTEX-V955-1826-SM-4JBIL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2059
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-ENSG_ID_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09599
PMC7608835-aba3058_Table_S4.xlsx-EWS-FLI1_RING1B_SEnh-Genes_containing_RING1B_EWSR1-FLI1_superenhancers_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19896
trpm	GeneRIF Biological Term Annotations	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Principal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26528
abnormal professional antigen presenting cell morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K18416855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08885
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85645
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-1726-SM-4LVME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05111
NCI-H2170	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.825108
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RI1	CCLE Cell Line Gene CNV Profiles	1.0	1.98609
8271_SON_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538959
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRKCA	KEA Substrates of Kinases	1.0	null
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68111
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
published	GeneRIF Biological Term Annotations	1.0	null
PHB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83187
hypokalemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.184128
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23371
BRD-K03765511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13261
BRD-K97746859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62172
BRD-K71554540_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DVL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0037481
regulation of atrial cardiac muscle cell action potential	GO Biological Process Annotations 2023	1.0	null
PFEIFFER	CCLE Cell Line Gene Expression Profiles	1.0	1.55178
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CMLT1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61012
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074438
abnormal adaptive immunity	MPO Gene-Phenotype Associations	1.0	null
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.995793
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.981341
Shortened Pr Interval	DisGeNET Gene-Phenotype Associations	1.0	null
positive regulation of developmental process	GO Biological Process Annotations 2023	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04305
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.827844
MCF7_Roscovitine_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159756
BRD-K29711480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22333
zimeldine-5670	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.840874
E2F7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00940916
cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.187646
penis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116819
BRD-K61772027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56232
BRD-K06666320_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
alpha-estradiol-5570	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cefuroxime-6088	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5016_MFAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.575047
biological_process	GO Biological Process Annotations 2015	1.0	null
cardiac conduction	GO Biological Process Annotations 2023	1.0	null
positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO Biological Process Annotations 2025	1.0	null
BRD-K12184916_-666_LOVO_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
third-degree atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.49
plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.28771
NSMCE4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13888
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AG-013608-5949	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary pulmonary hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20030272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31091
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.45567
GTEX-XBEW-0126-SM-4AT66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01149
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
SP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.841361
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204596
Endometrial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
HCFC1	ENCODE Transcription Factor Targets	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein modification process	GO Biological Process Annotations 2015	1.0	null
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.948731
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K71839680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46069
Vascular smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.061
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8312-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73451279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24198
GTEX-NFK9-0226-SM-2HMKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924511
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100666_HIP_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37404
GTEX-S4UY-0926-SM-4AD6O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941928
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
ca2	GeneRIF Biological Term Annotations	1.0	null
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892116
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12154
Keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CYB5R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25308
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cor pulmonale	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
PRX-08066	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
trifluoperazine-5221	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
benzthiazide-3329	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64029
Monocyte_Fetal kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
thioridazine-1486	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.445
H3K27me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU1J-1326-SM-46MUL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24629
Brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.137
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0123145
Adrenocortical carcinoma_ACC_TCGA-OR-A5J3-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uroepithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.094
DLGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16319
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Large_Intestine-goblet cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.0534467
organelle	GO Cellular Component Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200839,GSE233826_3_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
Tetralogy of Fallot	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850566
23132-87	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.9571
hek-293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.325701
Perturb_5360_KO_Tcf12_SRP392331	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.54548
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.890971
GSE241875_1_v_0_huwe1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
immune system process	GO Biological Process Annotations 2015	1.0	null
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52725
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
PTHLH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00698771
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.931051
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.72485
CYP17A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00820326
PMC7552962__F1	PFOCR Pathway Figure Associations 2024	1.0	null
ZNF274-21170338-K562_HELA_HEPG2_GM12878-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33827
ChIP_ESRRB_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_SW620_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alveolar bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.11604
BRD-K14441456_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67442425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17792
BRD-K96438475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27444
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
colonrectum_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.16771
BRD-K83670234_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Astroglial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.092
BRD-K65368100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03041
NUP133	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48677
BRD-A19500257_geldanamycin_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14985
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CHLA57	DepMap CRISPR Gene Dependency	1.0	4.29717
TARM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00802116
Ewing's sarcoma family tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
azapropazone-7277	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07619
bundle	GeneRIF Biological Term Annotations	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03648
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TNFSF15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0081847
GTEX-X4XX-0126-SM-3NMC2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988612
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68588
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16747
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
golgi apparatus	GO Cellular Component Annotations 2015	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00702226
PMC8304079__F1	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980373
KAT2B	ENCODE Transcription Factor Targets	1.0	null
EOMES	ChEA Transcription Factor Targets	1.0	null
Transmembrane transport of small molecules	Reactome Pathways 2014	1.0	null
SF172	Achilles Cell Line Gene Essentiality Profiles	1.0	1.35211
Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
right bundle branch block	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.36074
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
2162_DERL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.758553
KDM3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00479549
Hypertrophic cardiomyopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.22664
shikonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25738
9172_TONSL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613827
SNU245	CCLE Cell Line Gene Expression Profiles	1.0	1.38585
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.03768
positive regulation of membrane depolarization	GO Biological Process Annotations 2023	1.0	null
GTEX-R55C-1126-SM-48FCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65762
U031	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.96081
ALG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42081
cerebral	GeneRIF Biological Term Annotations	1.0	null
RT4	CCLE Cell Line Gene CNV Profiles	1.0	1.37071
erastin-6417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
monoatomic cation channel activity	GO Molecular Function Annotations 2023	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.882
peripheral	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K17858048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69737
BRD-K07895476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07831
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920802
Progressive familial heart block type II	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
EXTL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537259
BRD-K59149254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41539
Perturb_4880_KO_NOXA_SRP131666	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.04696
ETV1_01_179	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.61926
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inorganic cation import across plasma membrane	GO Biological Process Annotations 2025	1.0	null
PMC10204296-13578_2023_1034_MOESM16_ESM.xlsx-Black-ZNF671_ZNF671	Rummagene Transcription Factor Associations 2026	1.0	null
KLF4-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FS-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-6217-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of cell population proliferation	GO Biological Process Annotations 2023	1.0	null
BRD-K50168500_canertinib_SKBR3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94012289_OSI-027_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF274-21170338-K562-HELA	ChEA Transcription Factor Targets 2022	1.0	null
peptidyl-amino acid modification	GO Biological Process Annotations 2015	1.0	null
sulfasalazine-2882	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39583
Blood vessel wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.323
cytoplasmic	Phosphosite Textmining Biological Term Annotations	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4604
Prostate gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.554
A375	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5WG-1826-SM-4KL2Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939349
GP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560948
BRD-K43543979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11252
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2174
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.81399
SKNDZ	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60802
BRD-A17831693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16973
calcium- and calmodulin-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.369
regulation of anatomical structure size	GO Biological Process Annotations 2015	1.0	null
positive regulation of canonical Wnt signaling pathway	GO Biological Process Annotations 2023	1.0	null
Perturb_7977_KO_Smc3_SRP337222	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.38976
NELFE	ENCODE Transcription Factor Targets	1.0	null
regulation of blood circulation	GO Biological Process Annotations 2015	1.0	null
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.44234
DCTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77771
atractyloside-3435	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
betazole-1812	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3132
MIR222_KD_GDS4054_456_human_MCF7 breast cancer cells (fulvestrant-resistant)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC12055596-41375_2025_2570_MOESM4_ESM.xlsx-PDX1-Unnamed_14_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.883
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.3638
Glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.135
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48978
GTEX-P4PP-0126-SM-3LK69	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829839
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30977
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1223
Cystic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.832
GTEX-OHPK-2426-SM-3MJGH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853888
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.9224
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895197
BRD-K60557007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08645
Pancreatic beta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.909
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Get-1_Deficiency_GDS2629_161_mouse_embryonic skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
WT1-19549856-Wilms tumor-derived CCG99?11-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
heptaminol-7313	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fc-epsilon receptor I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.603
CNTN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622843
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22847
GABPA	ENCODE Transcription Factor Targets	1.0	null
SLC25A20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550196
establish	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FASN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0036774
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.1843
BRD-K46692335_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CDK13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587954
Glomerular layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.82
MED13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00681171
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76508844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25535
Prostate gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64588
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
B875 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.577
bisoprolol-6748	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	184.162
BRD-K72636697_QL-X-138_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH196	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.79582
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
AKR1C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00687752
BRD-K24377650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59358
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14306
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOT4-1426-SM-4B65T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980993
NCI-H1693	GDSC Cell Line Gene Expression Profiles	-1.0	-1.61007
BRD-K50140147_NVP-TAE684_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
trichlormethiazide-4198	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.113464
EW-7	GDSC Cell Line Gene Expression Profiles	1.0	1.66345
CRCGN009_HEPG2_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14275
PMC3571914-1471-2407-12-260-S3.pdf-18-FOXA2_FOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XOT4-0626-SM-4B66L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07239
regulation of cytokine production involved in immune response	GO Biological Process Annotations 2015	1.0	null
GSE175683_3_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_11158_KO_Mdr2_SRP070832	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.507
MXI1	ENCODE Transcription Factor Targets	1.0	null
BRD-K33425534_exemestane_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PGA1	DepMap CRISPR Gene Dependency	1.0	2.00245
PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File010.xlsx-ChIP-seq_defined_target_genes-PBX1_and_Notch3_common_target_gene_list_621_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A49680073_Cucurbitacin I_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
Brain endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.718
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2743
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53622
system process	GO Biological Process Annotations 2015	1.0	null
AZ 628	DeepCoverMOA Drug Mechanisms of Action	1.0	1.03
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HPEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.26
BxPC-3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.18035
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.58577
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4851
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.537
Rabies CVS-11_7day-Spinalcord_22116324_GSE30577	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.63046
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829594
hl-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.892223
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5705-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.981341
Heart septal defect	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8469
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z9-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Congenital heart block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09603
GTEX-QDVJ-1426-SM-48U1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872573
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04746
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RIPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17411
Arrhythmogenic right ventricular cardiomyopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
SNX20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495494
NCIH28	DepMap CRISPR Gene Dependency	1.0	2.12884
TEAD4	ENCODE Transcription Factor Targets	1.0	null
BRD-K00586442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02206
Cochlear duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.401
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058625
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34514
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00467823
STK36	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645051
Middle cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.877
CYP11B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500925
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
cellular	GeneRIF Biological Term Annotations	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15856
voltage	GeneRIF Biological Term Annotations	1.0	null
BRD-K66735566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16011
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.895082
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62507
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.246442
BRD-K25846934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44326
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.452
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
regulation of cytokine production involved in immune response	GO Biological Process Annotations 2023	1.0	null
abnormal calcium ion homeostasis	MPO Gene-Phenotype Associations	1.0	null
Perturb_1772_OE|KO_Erg|Gata2_SRP239807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC12055596-41375_2025_2570_MOESM4_ESM.xlsx-PDX1-Unnamed_13_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
BDKRB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00759484
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV0-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42558
8415_SRP54_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.508902
BRD-K71486304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01486
Medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.795
UACC-893	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.915282
GTEX-XPT6-2226-SM-4B66R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845992
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957446
BRD-K85402309_dovitinib_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49881
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	252.288
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
leflunomide-6102	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
atrophic muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.418019
nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065425
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24809
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64027
Small_Intestine	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.1379
MCF7_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017184
Clove	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
BRD-K38946705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62209
TAF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K12571248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21762
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brugada	GeneRIF Biological Term Annotations	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917179
vestibular labyrinth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193012
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Insulin secretion	KEGG Pathways 2026	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49408
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.861442
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A4ZB-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A34806832_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Digenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
6857_PSMC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542167
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64422
type	GeneRIF Biological Term Annotations	1.0	null
Vomeronasal organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.496
GSE149903_3_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2306
primary culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220604
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KH-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57442
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
blood-brain barrier	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.488
Perturb_14659_KO_Insm1_ERP127840	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YAP_OE_GDS3220_32_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K41888813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92682
BRD-A35989968_MEGESTROL ACETATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brugada syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.33414
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A18825024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01259
GTEX-U3ZH-1426-SM-4DXSR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874384
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral group of nuclei, left, ventral division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34521
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840399
dexamethasone-2079	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ABC1	CCLE Cell Line Gene CNV Profiles	1.0	1.69166
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.934944
ADAMTS5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547631
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.978881
BRD-K97440753_Dihydroergocristine mesylate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Long QT syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.325
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32019201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06434
BRD-K50168500_canertinib_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZFAND2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513581
SMC3	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
arrhythmia	HPO Gene-Disease Associations	1.0	null
hsa-miR-4472	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
skin_6a	HPA Tissue Sample Gene Expression Profiles	1.0	0.921623
embryonic kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.324605
ATPase dependent transmembrane transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.161
KDM1A	ENCODE Transcription Factor Targets	1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.73159
GTEX-QCQG-1626-SM-48U26	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93001
bundle branch block	HPO Gene-Disease Associations	1.0	null
CXXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40035
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78195641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.72376
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967865
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05793
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04219
Microglial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
ISG15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620631
GSE255680_1_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6021-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.466
Spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.251
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.897514
GSE85880,GSE85881_0_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3654_HBS1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.611142
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.465998
BRD-K73824630_SKATOLE_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Submucosal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
SCN2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00737861
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HTR6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564469
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71253424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14934
Acute Myeloid Leukemia_LAML_TCGA-AB-2985-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
methotrexate-6318	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A952-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
Septicemia	DisGeNET Gene-Disease Associations	1.0	null
CHD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00386266
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23444
lymphnode	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.842595
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.99129
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.026
GSE130620_1_v_0_kdm4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.743801
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GAST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549186
MDA-MB-361	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.89455
Sensory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.05
purification	GeneRIF Biological Term Annotations	1.0	null
Arrhythmogenic left ventricular cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824482
HDAC2	ENCODE Transcription Factor Targets	1.0	null
BRD-K32896438_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hypokalemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
Heart conduction disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
DMS-273	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.82813
Schaffer collateral - CA1 synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.736
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-1126-SM-48TBU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02168
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227891_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.5293
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.950516
OV7	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.72111
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.97868
BRD-K42804674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1147
LEF1_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
regulation of lymphocyte mediated immunity	GO Biological Process Annotations 2015	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.01152
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.52349
atp binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K07489055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13299
PMC6487024-13148_2019_658_MOESM2_ESM.xlsx-S3-ADNP-1_DMRs-Unnamed_11_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22907310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08603
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
bambuterol-7239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72327
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.912
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	1.0	2.19941
mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.264696
BRD-K91564773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49284
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69754
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Integumentary system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8613_KO_Ctcf_SRP078142	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.5047
9-phenanthrol	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
PDS5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515509
NoRC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.788
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86652
BRD-K26431593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2873
evidence	GeneRIF Biological Term Annotations	1.0	null
haloperidol-1539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.324823
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68732
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
BRD-K64393896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.72277
OV90	CCLE Cell Line Gene CNV Profiles	1.0	1.42267
Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.82968
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K23762204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44343
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09452
etomidate-7460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K56343971_vemurafenib_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal blood cell morphology/development	MPO Gene-Phenotype Associations	1.0	null
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200839,GSE233826_5_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
Right bundle branch block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.565
intrinsic	GeneRIF Biological Term Annotations	1.0	null
DJM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE136311_1_v_0_lyz2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
crig1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.519
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A3-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIVF001-007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26472
m8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.814
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.936976
Wolff-Parkinson-White syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16286
MFE-296	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39037393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04277
Hereditary night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12794
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CRCGN016_MCF10A.TP53.M_24H:C10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21421
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.36789
GSE118939_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
DEFB4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536007
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE184892_0_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.64
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE205163,GSE205164_5_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32079
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.707
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23961
arterial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.646505
DFFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00674451
protein binding	GO Molecular Function Annotations 2015	1.0	null
posteroventral (inferior) parietal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.941796
CTF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060067
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
SLC8B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02097
BRD-K21568472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.9348
6863_PSMC6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.506143
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Heterotrimeric G-protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.878
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ramos-2G6-4C10	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54724
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59919062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83262
Perturb_15527_OE_CPT1A_SRP292168	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.7189
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.81825
PMC7013742__F2	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K91980109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35005
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980373
lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052434
YY1	ENCODE Transcription Factor Targets	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152441,GSE152442_7_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_1_BioID_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE152432_1_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Longitudinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.977
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.678701
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2655
Perturb_6727_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.11253
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8944338__F4	PFOCR Pathway Figure Associations 2024	1.0	null
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S4-Supplemental_Table_S4_Genes_commonly_upregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
ovary_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.17641
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20487
BRD-K38615567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86943
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11178
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92246187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1908
Accessory olfactory bulb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.23
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.466498
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K27881453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34384
BRD-A69786436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30575
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
quinidine-3191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
h2o2mediated	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03049
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50914
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.33724
Migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
BRD-K95808480_taxifolin-(+/-)_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.349
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11589
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47999752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4629
Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
clindamycin-2057	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
large	GeneRIF Biological Term Annotations	1.0	null
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.808
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3836
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.50675
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
OVSAHO_OVARY	CCLE Cell Line Proteomics	1.0	2.50107
regulation of heart rate by cardiac conduction	GO Biological Process Annotations 2025	1.0	null
hsa-miR-4283	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
estradiol-1241	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22531
HCST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521806
Bone development disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52N-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.082461
Progressive familial heart block	ClinVar Gene-Phenotype Associations 2025	1.0	null
stomach	HPA Tissue Protein Expression Profiles	1.0	1.48277
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.36
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25361
Extrinsic component of cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.876
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.881667
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TOV112D	Achilles Cell Line Gene Essentiality Profiles	1.0	1.02869
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.915604
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38755
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04939
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K29628221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08735
BRD-K00231307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28819
BRD-K89141455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2617
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
secretion	GeneRIF Biological Term Annotations	1.0	null
positive regulation of action potential	GO Biological Process Annotations 2023	1.0	null
Perturb_11924_KO_JMJD3_SRP110517	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27322
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.25022
EOMES-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Allergic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
BRD-K03861440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54849
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SW1783	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.25794
Brugada syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
6283_PHF19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.589182
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
1588_CHMP6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.746793
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization	GO Biological Process Annotations 2025	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.941066
dizocilpine-6223	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WYVS-1626-SM-3NM9R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986002
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.791044
Capillary endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.193
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
josamycin-5692	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
benzonatate-1679	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46505
GTEX-X4EP-0126-SM-3P5YV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00171
CAOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33368
vomeronasal organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.432991
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
calmodulin	GeneRIF Biological Term Annotations	1.0	null
BRD-K02708799_GSK-1059615_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RU1J-0826-SM-46MUU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841179
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of cytokine production involved in immune response	GO Biological Process Annotations 2025	1.0	null
A band	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.948
639-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K77869064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11843
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073408
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R7-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AV node cell action potential	GO Biological Process Annotations 2023	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.90739
Familial atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00354
Lung adenocarcinoma_LUAD_TCGA-44-6776-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRPV5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590157
abnormal hematopoietic cell number	MPO Gene-Phenotype Associations	1.0	null
positive regulation of heart rate	GO Biological Process Annotations 2025	1.0	null
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K88573743_A443654_LNCAP_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K79090631_CGP-60474_MCF10A_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99252563_QL-XII-47_HME1_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.767
10924_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543527
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981052
BRD-K45665532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.84454
CCNT2	ENCODE Transcription Factor Targets	1.0	null
abnormal dendritic cell physiology	MPO Gene-Phenotype Associations	1.0	null
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152599
Cardiomegaly	CTD Gene-Disease Associations	1.0	1.37987
BRD-A89441445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50334
SC-19220-7065	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
GSE88819_5_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
fibers	GeneRIF Biological Term Annotations	1.0	null
SNU878	CCLE Cell Line Gene CNV Profiles	1.0	1.92672
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cardiac muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.419
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.500398
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31571
BRD-K97359891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27391
Cranial ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.362
BRD-K68853384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3258
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856158
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.993996
Acute Lung Injury_Lung Tissue_GSE1871	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.10384
Lymph node cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
FHIP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83906
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abnormal dendritic cell morphology	MPO Gene-Phenotype Associations	1.0	null
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.830312
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WAC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10158
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30974
BRD-K81932943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82682
PMC9084694-RMB2-21-e12464-s005.xlsx-GV_MI_MII_GV-up-GeneName_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10261
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54K-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198794_0_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
flufenamic acid	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15471
Sarcoma_SARC_TCGA-DX-A7EO-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypertrichotic osteochondrodysplasia Cantu type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.466
urapidil-5295	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.870574
Transient receptor potential cation channel subfamily M member 4	InterPro Predicted Protein Domain Annotations	1.0	null
positive regulation of action potential	GO Biological Process Annotations 2025	1.0	null
PMC10925000-12885_2024_12075_MOESM2_ESM.pdf-11-PURG_PURG	Rummagene Transcription Factor Associations 2026	1.0	null
imipramine-5440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49328571_dasatinib_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TET1-21490601-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
increased vascular permeability	MGI Mouse Phenotype Associations 2023	1.0	null
OMC-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.92713
HAL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558103
dilazep-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48048
biological regulation	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4591-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17744
PMC10921469__F9	PFOCR Pathway Figure Associations 2024	1.0	null
MTAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39876
BRD-K01639528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56516
estradiol-6718	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6484-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8477-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12171002-jcav16p2578s1.pdf-101-SIX2_SIX2	Rummagene Transcription Factor Associations 2026	1.0	null
Biceps brachii	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
positive regulation of insulin secretion	GO Biological Process Annotations 2025	1.0	null
carmustine-6914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
artery	GeneRIF Biological Term Annotations	1.0	null
UHRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51795
NCO2	CCLE Cell Line Gene CNV Profiles	1.0	1.50454
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6808
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PADI4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070494
crucial	GeneRIF Biological Term Annotations	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Epithelial lining fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
Sodium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-SE5C-1526-SM-4BRWU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79597
NCI-H520	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47715
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965153
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25774
BRD-K81574470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70824
BRD-K19269952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25979
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vallate papilla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
SKM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44781
C-fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.628
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50168500_canertinib_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
noscapine-7204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K71499752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17459
BRD-K86953192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23284
membrane depolarization during cardiac muscle cell action potential	GO Biological Process Annotations 2023	1.0	null
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Diazinon	CTD Gene-Chemical Interactions	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.057
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.14298
vasculature	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.400628
arecoline-6322	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
BRD-A75409952_wortmannin_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00282
BRD-K42361742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15107
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143955_1_v_2_ripk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K33770771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4468
regulation of membrane potential	GO Biological Process Annotations 2015	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
Nerve plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.625
movement of cell or subcellular component	GO Biological Process Annotations 2015	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.363393
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.35682
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.756408
BTP2	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Hypertension	CTD Gene-Disease Associations	1.0	1.35792
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35303
Endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.258
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902006
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21775
SETDB1-19884255-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
YAP1-20516196-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
URB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659399
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.67426
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
ELF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626055
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.83827
BRD-K85513726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64405
HuO9	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54842
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053426
TECPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14346
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03565
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K93737936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33095
EOMES-20176728-TSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
5557_NDUFB5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.650595
GSE218960_0_v_1_nrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_4_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5689-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Infertility, Male	CTD Gene-Disease Associations	1.0	1.10803
Endolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.023
Left middle cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ES3	GDSC Cell Line Gene Expression Profiles	1.0	1.49241
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.89169
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vascular smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.496
Intracranial aneurysm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.56
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882907
Atrioventricular Block	DisGeNET Gene-Disease Associations	1.0	null
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916874
CHP-126	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.333028
african	GeneRIF Biological Term Annotations	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.834138
BRD-K63787803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65385
MAZ	ENCODE Transcription Factor Targets	1.0	null
Macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.086
fluphenazine-7234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
BRD-K02065805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53434
Cardiovascular phenotype	ClinVar Gene-Phenotype Associations 2025	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SR cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.529
Ileum smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.301
GTEX-XQ8I-0426-SM-4BOPO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923922
ONS76	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43041
BRD-A02481876_Importazole_SNUC4_6.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
methazolamide-6268	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oxybenzone-6309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39636
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046265
bone marrow cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.306083
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41215
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C-4-I	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.90941
isoxsuprine-4205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
unanticipated	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SLR20	DepMap CRISPR Gene Dependency	1.0	2.78058
GSE147876,GSE147877_4_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.28456
GTEX-OOBJ-1526-SM-3NB1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11988
NB4	DepMap CRISPR Gene Dependency	1.0	5.11876
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.124844
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47721
Smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.107
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0262
MCAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00706179
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
regulation of vasoconstriction	GO Biological Process Annotations 2025	1.0	null
Vermiform appendix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.916
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00142
LU65_LUNG	CCLE Cell Line Proteomics	1.0	5.14265
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Caveola	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.322
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
BRD-K57497543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55668
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840968
hsa-miR-4758-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
inorganic cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
abnormal dendritic cell number	MPO Gene-Phenotype Associations	1.0	null
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8027
CCL21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556231
SPTAN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00452937
cell part	GO Cellular Component Annotations 2015	1.0	null
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.386593
monoatomic ion gated channel activity	GO Molecular Function Annotations 2023	1.0	null
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5952
Arrhythmogenic right ventricular cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.857
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.028881
component	GeneRIF Biological Term Annotations	1.0	null
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.779229
AP5B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548041
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35915
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FTC-133	COSMIC Cell Line Gene Mutation Profiles	1.0	null
vestibular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193998
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sensory perception of sweet, bitter, and umami (glutamate) taste	Reactome Pathways 2024	1.0	null
PMC6420620-41598_2019_Article_39571.nxml--Receptome_CPC_vs_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
external female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.140393
Large_Intestine-immature enterocyte	Tabula Sapiens Gene-Cell Associations	1.0	5.63198
TBP	ENCODE Transcription Factor Targets	1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BTN3A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666959
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13368
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
calcium ion binding	GO Molecular Function Annotations 2025	1.0	null
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07563
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26171
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26727
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25148
BRD-K41141507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53246
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
etamivan-7021	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01
ivermectin-2051	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Carcinoma	CTD Gene-Disease Associations	1.0	1.18193
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A460-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826587
H3K79me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H322M	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.15685
18614019-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S341-0726-SM-4AD5R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973721
Prostate adenocarcinoma_PRAD_TCGA-VN-A88R-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
biophysical	GeneRIF Biological Term Annotations	1.0	null
3978_HSPA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.11294
KP2	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.01784
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290781
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24674
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FC-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VAV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00929729
EDD_DEPLETION_GDS2445_116_human_embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
valproic acid-6934	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
metoclopramide-4750	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bergenin-5870	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K43544024_Oxandrolone_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84401063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06808
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06835
RAD21	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cytoplasmic side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.866
Sweet taste receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.961
BRD-K49328571_dasatinib_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
duodenum	HPA Tissue Gene Expression Profiles	1.0	0.829114
GTEX-S4Q7-1026-SM-4AD75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42903
BRD-K67868012_PI-103_SKBR3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Status epilepticus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219584
BRD-A09533288_VERAPAMIL HYDROCHLORIDE_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07237224_4-chloro-n-(2-morpholin-4-yl-ethyl)-benzamide_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A695-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CE-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077988
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.251476
PSMB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11661
BFTC905	DepMap CRISPR Gene Dependency	1.0	2.80295
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
BRD-K94440323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38598
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.781678
compartment	GeneRIF Biological Term Annotations	1.0	null
Connecting tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02266
CBC2231 (AKAP8)	NURSA Protein Complexes	1.0	null
Cardiomyopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
CALU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00357045
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132313_1_v_0_fosl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-51	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.13023
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
TFAP2C	ChEA Transcription Factor Targets	1.0	null
protein tetramerization	GO Biological Process Annotations 2023	1.0	null
PCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.007805
MOLT-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nb4	HPA Cell Line Gene Expression Profiles	-1.0	-1.23306
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33174
SMG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12598
Cardiac Hypertrophy_Myocardial tissue_GSE5500	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.91568
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.071177
1747_COG8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.634635
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Embryonic kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.041
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.29399
BRD-K57035236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02088
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45552
AGS	CCLE Cell Line Gene CNV Profiles	1.0	1.73395
doxylamine-1473	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K51791390_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.769
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Erythrokeratodermia variabilis et progressiva	ClinVar Gene-Phenotype Associations 2025	1.0	null
GTEX-OIZH-2026-SM-3NB1M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2613
SETDB1	ChEA Transcription Factor Targets	1.0	null
flunisolide-3747	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.26945
prochlorperazine-5212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Cardiac muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.146
progressive	GeneRIF Biological Term Annotations	1.0	null
BRD-K64221857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18154
PMC4838354-supp_gkv1491_nar-01150-met-k-2015-File011.xlsx-Differentially_expressed_genes-Differntially_expressed_PBX1_and_NOTCH3_common_genes_under_GSI_FC_1_3_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
protein modification by small protein conjugation	GO Biological Process Annotations 2015	1.0	null
BRD-K71538933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29749
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09494
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.51335
BRD-K49303291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39441
cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-OIZH-0126-SM-2HMIS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904249
PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10981
intestinal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24804
BRD-A35869383_ibrutinib_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5253409-961	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
GSE162892_3_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CILP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558974
Endometriosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
GFOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08347
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.915706
FAM234A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38833
BRD-K22390389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37252
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QQ-A5VD-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Luminal breast carcinoma B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
Ethmoid bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.531
divalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.012
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
EB-67-WB79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210309
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.861745
GTEX-XBED-1426-SM-4AT4G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18375
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24036
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.903
cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.897872
BRD-K94325918_-666_HT115_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Melanophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
second-messenger-mediated signaling	GO Biological Process Annotations 2023	1.0	null
estriol-7220	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
betacatenin	GeneRIF Biological Term Annotations	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57251
MTCH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594254
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
IPO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87339
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417381
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75275329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23208
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADP	DGIdb Drug Targets 2026	1.0	0.444807
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	291.163
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.275794
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97538
MONOMAC1	CCLE Cell Line Gene Expression Profiles	1.0	1.58372
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal hematopoiesis	MPO Gene-Phenotype Associations	1.0	null
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SIU8-0126-SM-2XCDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01876
positive regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
RERF-LC-MS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
gated channel activity	GO Molecular Function Annotations 2015	1.0	null
Cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.427
Papilloma	CTD Gene-Disease Associations	1.0	1.01062
BRD-K44100512_KIN001-043_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4866-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DDX52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21635
PMC8650121__F1	PFOCR Pathway Figure Associations 2024	1.0	null
7556_RRM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540195
BRD-K50168500_canertinib_SKBR3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.537
Mucin granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.572
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
NUDHL1	CCLE Cell Line Gene Expression Profiles	1.0	2.34798
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5584-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22204
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Apical dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.12
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	355.068
Dorsal claustrum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00006
BRD-K27914478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29732
NBsusSR	GDSC Cell Line Gene Expression Profiles	1.0	1.52898
BRD-K93337444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17455
Heart valve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98571
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97022
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31889353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66949
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Traumatic brain injury	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.189
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Medial entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.871
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.213322
PMC10932085__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Uveal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
GTEX-R55D-1826-SM-48FEF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23685
nor10	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05123945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01669
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
PMC10247733-41408_2023_863_MOESM4_ESM.pdf-591-ZNF774_ZNF774	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oocyte	GeneRIF Biological Term Annotations	1.0	null
Long QT syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
regulation of heart rate by cardiac conduction	GO Biological Process Annotations 2023	1.0	null
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H513	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.97669
Sensory perception of taste	Reactome Pathways 2024	1.0	null
BRD-K67194214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.1308
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15153
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13171_KD_Ncor2_SRP060657	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.06306
regulation of cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
BRD-K27723822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79536
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02805
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14563
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of developmental process	GO Biological Process Annotations 2025	1.0	null
Ion channel transport	Reactome Pathways 2024	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cardiac arrest	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.081
Microglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.86
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-1826-SM-4E3K8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76096
GTEX-V1D1-2226-SM-3NMAX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00615
mitral cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.347408
KCNH7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662609
MAP4K1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00430813
BRD-K57080016_selumetinib_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100548_HIP_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04314
BRD-K02822062_CT-200783_CL34_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29196
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052731
CRCGN011_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0886
Spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.395
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-GeneName_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61742182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15436
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6901
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25551
Plasma membrane raft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.319
calycanthine-2764	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH1781	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46997
GTEX-QVJO-0526-SM-447CE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87945
A204	BioGPS Cell Line Gene Expression Profiles	1.0	0.857093
kidney disease	GWASdb SNP-Disease Associations	1.0	1.0434
Protein processing and intracellular signaling	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00417903
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.047
MYC-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
SLC19A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08714
BRD-K46913557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85492
Cerebellar cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.524
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.3976
BRD-K31554491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2068
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
block	GeneRIF Biological Term Annotations	1.0	null
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Left atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.243
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
MYOG_myocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TWNK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01619
BNC1_KD_GDS1978_70_mouse_oocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62446
BRD-K85567359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37992
Pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.008
PMC7912581__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.40296
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
t66-lung_male_8w	MoTrPAC Rat Endurance Exercise Training	1.0	3.4207
BRD-A39646320_H7270_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Odontoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.803
BRD-K45495792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12315
lymphocytes	GeneRIF Biological Term Annotations	1.0	null
BRD-K46936109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.907
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
myotonic dystrophy type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.199681
T3M4	BioGPS Cell Line Gene Expression Profiles	1.0	0.915343
corynanthine-4227	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46137
voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.822
Eye cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
5255229-949	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_MK-0752_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127128
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33760911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26089
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
kanamycin-5686	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HSC2	DepMap CRISPR Gene Dependency	1.0	2.20749
St Segment Elevation (Finding)	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K19930413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17753
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
ampicillin-5408	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GLDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556327
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.563
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization	GO Biological Process Annotations 2023	1.0	null
flunisolide-6023	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HICS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.647
CRCGN015_MCF10A.WT.HP_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00684
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
regulation of blood vessel size	GO Biological Process Annotations 2015	1.0	null
ALDH3B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502401
BRD-K16621777_S1174_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Inner medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
PMC7794837__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61423234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02337
EW-11	GDSC Cell Line Gene Expression Profiles	1.0	1.66061
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.861442
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
urinary bladder smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.10314
TRAF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642998
investigated	GeneRIF Biological Term Annotations	1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12204
GTEX-XUZC-0726-SM-4BOPH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962367
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CLOTRIMAZOLE	DGIdb Drug Targets 2026	1.0	0.0864902
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO Biological Process Annotations 2015	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cardiomegaly	DisGeNET Gene-Phenotype Associations	1.0	null
dicloxacillin-5012	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K48880196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53727
EFM192A	CCLE Cell Line Gene CNV Profiles	1.0	1.33334
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K55454768_TAS 301_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.885478
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29704
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06075
Ca<sup>2+</sup>	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Labellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33564
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060934
BRD-K53720386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48078
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295206
BRD-A28970875_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cefoperazone-6323	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
GTEX-X4EO-0326-SM-3P5YO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863253
transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.131729
BRD-K54364215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.076
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rad17 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.931
PC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.3
Sepsis	DisGeNET Gene-Disease Associations	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
PMC12534504-41598_2025_20489_MOESM1_ESM.pdf-389-MYCN_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JR	DepMap CRISPR Gene Dependency	1.0	3.49331
Sick Sinus Syndrome	DisGeNET Gene-Disease Associations	1.0	null
all	HPO Gene-Disease Associations	1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45101
NB6	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4676
RTEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01585
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
PMC8957101__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NI-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAK-901_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00346497
REST	ENCODE Transcription Factor Targets	1.0	null
Short QT syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.95
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15294
Brugada syndrome	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	5.0
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Uveal melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.6776
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endometrial stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.91
LMNB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670609
GSE160373_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Restrictive cardiomyopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
amitriptyline-1701	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26354
Stereocilium bundle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.828
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7794837__F1	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-A58767537_afatinib_SKBR3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dropropizine-7429	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
driving	GeneRIF Biological Term Annotations	1.0	null
dorsolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.933066
GTEX-XXEK-1026-SM-4BRUW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992941
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.505
brain	GTEx Tissue Gene Expression Profiles	-1.0	-0.832926
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
naftifine-7032	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-11A-02R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983202
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51534
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.768
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K72726508_Arcyriaflavin A_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30787
GSE152441,GSE152442_1_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.853603
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.85675
SUZ12	ENCODE Transcription Factor Targets	1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49484
SW1417	CCLE Cell Line Gene CNV Profiles	1.0	1.36366
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of cellular process	GO Biological Process Annotations 2023	1.0	null
UMUC9	DepMap CRISPR Gene Dependency	1.0	2.49175
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tanespimycin-5566	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
608_ATF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516337
BRD-K74402642_Chemistry 2804_SNUC4_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.813
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IBA	DGIdb Drug Targets 2026	1.0	3.11365
proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.160658
multiple	GeneRIF Biological Term Annotations	1.0	null
ChIP_SETDB1_19884255	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Purvalanol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
BRD-K48987279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17437
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95574976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66182
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26835
BRD-K03923461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47325
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.72163
Entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.015
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein-kinase-c	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21878
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616744
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.996474
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.934783
BRD-K48592348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21249
flumetasone-3410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02624
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61386375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48051
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2324
CDK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00916
NCIH2882	DepMap CRISPR Gene Dependency	1.0	5.1856
GSE72895,GSE72896_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75527
CHD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-WOFL-0626-SM-3MJG3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911356
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932413
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LAMA84	CCLE Cell Line Gene Expression Profiles	1.0	1.38045
Cortical collecting duct cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.982
endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.368998
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16733
mephenesin-4698	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Basophilic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
pimosertib	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03139
thiethylperazine-5756	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17540_OE_DAXX_SRP351980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.46874
thus	GeneRIF Biological Term Annotations	1.0	null
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
pyrimethamine-4194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mediates	GeneRIF Biological Term Annotations	1.0	null
CRCGN014_HEPG2_3H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16109
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
chemotaxis	GO Biological Process Annotations 2015	1.0	null
dizocilpine-2232	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ovary_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.1564
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520121
BC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.61857
BRD-K33098168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52036
VCAP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.1297
6771_PRKRIP1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.60426
Rumen epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.759
prazosin-942	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12181036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08995
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PF-01378883-00-6410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1772_COPB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.575785
BRD-K08431704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44951
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5431
GSE124410_1_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6135_PCNA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.806444
Short QT syndrome	ClinVar Gene-Phenotype Associations 2025	1.0	null
THP1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.18643
BRD-K62369921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04784
GTEX-QEG4-0226-SM-2S1PY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829753
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35775
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5260-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2819
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.32443
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.33388
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
aorta thoracica	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.189385
GTEX-XMK1-1726-SM-4B64Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57432
tsA-201 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.32
MAPK1IP1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00351211
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FGA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00504278
TCFAP2C-20176728-TROPHOBLAST-STEM-CELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9374162-mmc4.xls-KD_gene_list_heatmap_235_genes-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
oscillations	GeneRIF Biological Term Annotations	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17217
protein modification by small protein conjugation	GO Biological Process Annotations 2025	1.0	null
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB157	CCLE Cell Line Gene CNV Profiles	-1.0	-1.98494
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.54427
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WM-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051488
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20705
Trachea	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.877299
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860485
BRD-K04488512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38954
Learning Disorders	CTD Gene-Disease Associations	1.0	1.37275
BRD-K13330525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06196
BRD-K49424866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31525
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.847163
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain capillary endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.952
DU-145 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.29
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12153
Sarcoma_SARC_TCGA-DX-A3UB-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32982
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
effects	GeneRIF Biological Term Annotations	1.0	null
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3298
Perturb_8009_KD|OE_PSAT1|TP53_SRP406950	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Congenital stationary night blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.9514
protein sumoylation	GO Biological Process Annotations 2025	1.0	null
oxetacaine-1484	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
because	GeneRIF Biological Term Annotations	1.0	null
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
AMP-PNP	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K73463737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03954
voltage-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.601
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38221
GSE231799_2_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KMOE-2	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.52188
Outer dense plaque of desmosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
prostate_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.14362
blood	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-1011-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NOS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12077394-giaf035_giga-d-24-00380_revision_2.pdf-15-HMG20B_HMG20B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99859971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78737
ADCY7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00711313
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4QT-2426-SM-3NMCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972082
YBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52337
TE-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.966847
GSE213588_9_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EFO21	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.11635
lobelanidine-5080	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45462
SEC14L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543448
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54162
8230_SNRPD3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696895
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Somatodendritic compartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	154.695
BRD-K84278600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14571
Lung adenocarcinoma_LUAD_TCGA-93-A4JP-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061572
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.49304
Detrusor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.935
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
periglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.319863
GTEX-Q2AI-0926-SM-48U1F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7057
GPR17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0074676
Perturb_10872_KO_fatp2_SRP229353	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.91256
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cochlea	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.200647
molecular_function	GO Molecular Function Annotations 2015	1.0	null
PMC7013742__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0686
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0508
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
PSMB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599409
Mucolipidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.801
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57786
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vestibular labyrinth	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.398
Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183271_1_v_0_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TET1	ChEA Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.74142
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08799
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.54985
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.46842
TCF3	ENCODE Transcription Factor Targets	1.0	null
CLCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0068683
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.71227
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chlorpromazine-1700	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
highly	GeneRIF Biological Term Annotations	1.0	null
BAS-012416453-6908	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5119679__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07229
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89161
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24729
GTEX-OXRL-0126-SM-2YUMP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01751
CAPZB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50344
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PTEN_DN.V2	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.75113
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039311
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85044233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05017
Perturb_17364_Mut|OE_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.87056
neuronal	GeneRIF Biological Term Annotations	1.0	null
modiolus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.550503
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829505
thioridazine-1655	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Unnamed_1_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38514
MCF7_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171369
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QLQW-0426-SM-447A7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77482
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.97396
Perturb_12540_KO|OE_FBXO11|FBXO11_SRP278534	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.7932
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6703
ion	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.20022
PDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060989
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.71137
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K14364923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19019
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	3.53652
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52855
MM485	DepMap CRISPR Gene Dependency	1.0	4.64378
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00836
EB2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51572
BRD-A20243730_Danazol_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.48277
DMS273_LUNG	CCLE Cell Line Proteomics	1.0	2.1351
female pudendum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.158914
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21012
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.73495
BRD-K93186184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33269
1906_CSNK2B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552213
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.36
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.1667
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
entry	GeneRIF Biological Term Annotations	1.0	null
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.270434
786-0	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.05094
CDKAL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00402623
GSE99187_1_v_0_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of vasoconstriction	GO Biological Process Annotations 2023	1.0	null
PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.60493
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1512
FOLR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0046308
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13136
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.60173
11906190-Table2a-1	GeneSigDB Published Gene Signatures	1.0	null
PMC12077394-giaf035_giga-d-24-00380_revision_1.pdf-19-THYN1_THYN1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223008_0_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Left Anterior Fascicular Block	DisGeNET Gene-Disease Associations	1.0	null
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-0126-SM-2YUND	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826307
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29806
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.597924
Vagus nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.57
riluzole-3666	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0267
GSE146840,GSE146842_0_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Progressive familial heart block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.27
carcinine-3242	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K25447152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70207
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-0126-SM-4DM6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05227
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63926
abnormal acute inflammation	MPO Gene-Phenotype Associations	1.0	null
BRD-A23637604_oxymetholone_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Av Block First Degree By Ecg Finding	DisGeNET Gene-Phenotype Associations	1.0	null
laminin-4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
HENMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15626
PMC8047323-Table_2.xlsx-LPS_PMMA_T24-GeneSymbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ASNS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00371673
OD-96-OP94_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203172
GTEX-RU72-2226-SM-46MUE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934415
SUPT5H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.1279
negative regulation of ossification	GO Biological Process Annotations 2023	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3YL-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intestinal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.15
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52995
BRD-A19037878_trichostatin A_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
clozapine-1229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1048	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A_48H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54645