association dataset threshold value standardized value Distal arthrogryposis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.16 Zic1::Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.9746 medial tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18467 r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60314 IFI6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16954 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE60837_6_v_4_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null STAT1 ENCODE Transcription Factor Targets 1.0 null H1 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.10118 Supplemental somatosensory area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4955 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CC-90-EX35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.302436 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26672 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null substantia innominata, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22474 Perihypoglossal nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02692 GTEX-WWYW-0426-SM-3NB31 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971688 7476_RPL6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.504767 PML ENCODE Transcription Factor Targets 1.0 null ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.1932 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CB-87-RB49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.847392 GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02982 Bed nuclei of the stria terminalis, anterior division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08716 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 0.869139 K562_Tie2 kinase inhibitor_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.023066 H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 562_ASAP1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.730664 YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.48459 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLT8D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06283 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31973 DANG_PANCREAS CCLE Cell Line Proteomics 1.0 2.74144 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NB1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.98105 GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.860985 Perturb_5014_OE_Prdm15_SRP064415 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.01725 STAT3-18555785-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null 7426_RPF1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.523383 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33899 K562_AICAR_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0183449 MYC ChEA Transcription Factor Targets 1.0 null GSE186810,GSE186813_2_v_1_furin_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIX5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112761,GSE112767_1_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null r7 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94206 Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ion binding GO Molecular Function Annotations 2015 1.0 null GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94664 CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.949105 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null MTHFSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.572 Perturb_14304_KD_HNRNPC_SRP230637 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.5512 Perturb_657_KD_lncRNA_141992_SRP093784 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.97942 8232_SNRPF_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.568641 Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.880706 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -3.15727 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null KPNYN CCLE Cell Line Gene Expression Profiles -1.0 -1.85176 MAX_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_653_KD_lncRNA_104449_SRP093784 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.82203 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053809 MC-IXC Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.1113 PMC9391117-ECAM2022-7812218.pdf-2-PCGF6_PCGF6 Rummagene Transcription Factor Associations 2026 1.0 null paracentral lobule, posterior part, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.963575 NCCIT COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 A549_Fulvestrant_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158855 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANKS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33954 superficial stratum of PrS (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36984 periventricular stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45267 RNA splicing, via endonucleolytic cleavage and ligation GO Biological Process Annotations 2023 1.0 null POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.53039 Archease domain InterPro Predicted Protein Domain Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.37701 GSE225647_1_v_3_srsf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GD-73-ZF64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.306669 CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2789_EXOSC2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.617295 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ECC12 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE151612_0_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles 1.0 1.2709 507_ARL2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.71233 PMC3076323-pone.0018064.s016.xls-MYCN_targets_Marson_GSE6007-Unnamed_1_MYCN Rummagene Transcription Factor Associations 2026 1.0 null estradiol_homo sapiens_gpl570_gse5102 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-TSE9-0011-R9A-SM-3DB7Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.90916 K562_RG108_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.02742 cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35032 MCF7_S3I-201_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0202353 Olfactory tubercle Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23749 E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE138938_1_v_3_foxp2_human RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null deferasirox_homo sapiens_gpl570_gds3558 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TAF7_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4 ChEA Transcription Factor Targets 1.0 null GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831476 spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.943558 RUNX1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 5730_NOC3L_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.529007 TE441T CCLE Cell Line Gene Expression Profiles -1.0 -2.19938 H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE188570,GSE188571_3_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null FOSL1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null lymphnode_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.15573 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886994 H3K18ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null HNF4G_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_AICAR_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165813 GATA3_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 2 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12247 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null L-Cysteine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.32 5860_NUDCD3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.5944 BOLA2 Pathway Commons Protein-Protein Interactions 1.0 null BATF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XBED-0826-SM-47JYC GTEx Tissue Sample Gene Expression Profiles 1.0 1.23959 UFM1 Pathway Commons Protein-Protein Interactions 1.0 null Esophagus - Muscularis GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.848309 NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles 1.0 1.51251 Hypoglossal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66337 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNCA Pathway Commons Protein-Protein Interactions 1.0 null 496100395_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.40183 POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6860_PSMC3_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.03584 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01532 salivary gland HPA Tissue Protein Expression Profiles 1.0 1.49892 FOS ENCODE Transcription Factor Targets 1.0 null PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.61774 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null GSE202434,GSE202438_3_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH2171 CCLE Cell Line Gene Expression Profiles 1.0 1.55734 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Amisulpride_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0213627 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950001 Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 8184_SMN2_ENST00000380743.4 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.628133 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inner CP in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838238 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ovary HPA Tissue Gene Expression Profiles -1.0 -1.32108 klf9_17379758_jejunum_lof_mouse_gpl339_gds2703 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.584505 central GeneRIF Biological Term Annotations 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null trim28_23493425_cd71pluster119plus_sorted_from_bone_marrow_lof_mouse_gpl6887_gse44063 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.136166 GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles 1.0 1.99501 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11239 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-1126-SM-48U19 GTEx Tissue Sample Gene Expression Profiles 1.0 0.843711 2988_FBL_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.831858 BDH2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954572 NCI-H1651 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE128844_0_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null Type IV pilus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.017 NCIH1092 CCLE Cell Line Gene CNV Profiles 1.0 1.374 leukocyte disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.554791 LS-180 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.02471 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.54758 9473_U2AF1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.658945 4523_LAS1L_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.537712 PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-RA_812_genes_expression_ratio_in_ZF_and_OF_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null 9841_WDR75_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.601718 u937 HPA Cell Line Gene Expression Profiles 1.0 0.890613 hsa-miR-4711-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 Perturb_13254_KD_Ncaph2_SRP073037 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.1382 AP1S2 ChEA Transcription Factor Targets 1.0 null Perturb_13262_KO_chr9_SRP162484 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.66898 YY1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE135030_11_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.58057 KMRC3 CCLE Cell Line Gene Expression Profiles -1.0 -2.71984 ventrolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.953745 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null estradiol_homo sapiens_gpl1225_gse1486 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.279659 PADI4-21655091-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.71591 inner CP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.88076 A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_1day-MOI-10^4_None_GSE37572 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.77484 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles 1.0 2.01583 GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11166 Perturb_15671_KD_Cebpb_SRP160879 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.45047 SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null PA-80-RV09_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.411528 paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.937044 4147_INTS2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.527719 K562_SRT3025 HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0263059 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.77312 GTEX-WYBS-1926-SM-3NM8N GTEx Tissue Sample Gene Expression Profiles 1.0 0.826144 GSE183251_4_v_6_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null r8 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.03622 GTEX-TSE9-2226-SM-4DXUR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19457 K562_Busulfan_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0279389 GTEX-P4QS-0726-SM-3NMCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.06128 A549_FLLL32_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0171492 SETDB1 ChEA Transcription Factor Targets 1.0 null 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.845547 GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFE2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_CEP-33779_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014448 GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891447 PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_12_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE70883,GSE71179_0_v_1_pbx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PIAS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04917 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100421_PCx_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.23183 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42427 Medial amygdalar nucleus, anterodorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30886 cooperation GeneRIF Biological Term Annotations 1.0 null Perturb_4521_KO_Mapk1/Mapk3_SRP281895 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.05285 3677_HEATR1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.550242 GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056068 GSE202434,GSE202438_15_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ELK1-22589737-MCF10A-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE217776,GSE217829_1_v_6_sgf29_human RummaGEO Gene Perturbation Signatures 1.0 null DMS153 CCLE Cell Line Gene CNV Profiles 1.0 1.67758 GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.25181 orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27604 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43187 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RN-01A-12R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER ChEA Transcription Factor Targets 2022 1.0 null GSE109913_1_v_2_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null RELA_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950001 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 4208_ISG20L2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.839958 superficial stratum of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08642 9424_TUBG1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.62747 Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17594 GTEX-RWS6-0001-SM-3NMAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.89793 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.66646 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11668 POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SYNJ2BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10413 A549_SB431542_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0136533 MC116 CCLE Cell Line Gene Expression Profiles 1.0 2.79038 GSE214442_0_v_1_pak4_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_13_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null NRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE232472_1_v_2_apoe_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-320a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 pancreas GTEx Tissue Gene Expression Profiles -1.0 -1.10289 5504_NCL_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.573928 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A72E-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCSK9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38948 6536_POLR1C_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.576915 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01217 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE111247_14_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null LTBR_INHIBITION - 1 Day_GDS2004_733_mouse_Lymph nodes (MG-430A) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_2313_KD_LUC7L2_SRP268983 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.54425 Tolimidone DeepCoverMOA Drug Mechanisms of Action 1.0 0.46 MCF7_Valproic acid sodium salt_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0125212 CHD1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Fulvestrant_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157411 GTEX-NPJ8-2526-SM-2HML8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12227 H3K4me1_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GATA2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213228_4_v_5_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_28_OE_Smad1_SRP217699 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.19949 TFEB ChEA Transcription Factor Targets 1.0 null KMRC3 CCLE Cell Line Gene CNV Profiles -1.0 -1.48832 A549_Dacinostat_10nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0105285 trna-splicing ligase complex GO Cellular Component Annotations 2015 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44975 ChIP_SOX2_19030024 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null K562_Clevudine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0228089 GSE183413_1_v_2_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bed nuclei of the stria terminalis, anterior division, anteromedial area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06376 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.16681 ERK5-IN-2_hTERT-HPNE Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.00373122 lymphnode_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.40368 MAFK_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4LF-0426-SM-3NMB5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06656 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_9515_KO_Sall4_ERP111723 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 19.3979 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null WC-59-RG09_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.514583 MCF7_ENMD-2076 L-Tartaric acid_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0284629 YTHDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05145 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FBXO10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04823 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.00597 GTEX-V1D1-0926-SM-4JBHQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.972283 GTEX-OIZH-2026-SM-3NB1M GTEx Tissue Sample Gene Expression Profiles 1.0 1.06347 Binospirone DeepCoverMOA Drug Mechanisms of Action -1.0 -0.27 POU2F2 ENCODE Transcription Factor Targets 1.0 null cuneus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.937131 Heart Defects, Congenital CTD Gene-Disease Associations 1.0 1.02336 K562_Mesna_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0234085 Tail muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.634 Optic lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.041 Perturb_10350_KD_Zbtb17_ERP119985 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.90327 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053159 GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05475 GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10722 NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.7747 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null P53-21459846-SAOS-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC7339546-12915_2020_793_MOESM2_ESM.xlsx-Table_S12-Table_S12_common_twin_genes_in_one_HMR_core_region_between_cattle_and_human_NR4A1 Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Alendronate sodium trihydrate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152662 CA46 CCLE Cell Line Gene Expression Profiles 1.0 1.43085 USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 0.928265 K562_Ki16425_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0249294 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.901047 Branchial arch TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.985 SPI1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE252857_2_v_0_klf15_mouse RummaGEO Gene Perturbation Signatures 1.0 null medial part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09833 GSE121043_0_v_1_aldh1a1_human RummaGEO Gene Perturbation Signatures 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Trametinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00968617 GTEX-WFJO-0326-SM-3GIL3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2519 GSE138789_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null Tibialis posterior TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.673 RELA ENCODE Transcription Factor Targets 1.0 null EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gastric Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.872816 ERF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6451 periventricular stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01931 Thyroid GTEx Tissue Gene Expression Profiles 2023 1.0 5.9393 K562_GSK J1_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015852 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null blood vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.36302 H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243426 immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049137 TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XAJ8-0626-SM-47JY4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.971169 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Medial cuneiform bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.58 PRECLH CCLE Cell Line Gene Expression Profiles -1.0 -1.84193 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SB-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RVPU-2226-SM-2XCAQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944022 POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NT5C Pathway Commons Protein-Protein Interactions 1.0 null K562_Mocetinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0132779 SOX2-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HOXD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9798 GSE158815_5_v_3_trib1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766 Rummagene Transcription Factor Associations 2026 1.0 null Bed nuclei of the stria terminalis, anterior division, anterolateral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22048 rna splicing GO Biological Process Annotations 2015 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4167-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA3_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_10_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null 7459_RPL31_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.800332 17683608-TableS2 GeneSigDB Published Gene Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DENND10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41435 CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE202434,GSE202438_9_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01572 GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63166 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00542 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14677 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null tonsil HPA Tissue Protein Expression Profiles 1.0 0.820025 3568_GTF2B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.713223 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null A549_Regorafenib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0154226 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO668 CCLE Cell Line Gene CNV Profiles 1.0 1.87727 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32492 GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21312 tonsil_8a1 HPA Tissue Sample Gene Expression Profiles 1.0 1.91607 TMEM130 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14153 5745_NOP10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.555035 GTEX-OXRL-0726-SM-3NM9A GTEx Tissue Sample Gene Expression Profiles 1.0 0.840425 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27877 SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJYA-0326-SM-3GAEX GTEx Tissue Sample Gene Expression Profiles 1.0 1.16694 BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QCQG-0226-SM-48U28 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17784 WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13388 6550_POLR2I_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.554745 UBTF ENCODE Transcription Factor Targets 1.0 null anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76468 Perturb_8708_KD_Irf2_SRP193480 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.86004 RELB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5122 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.99997 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92887 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE166004_3_v_6_pld1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r4 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73706 PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-EGR1_DC_ChIP-seq_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Tofacitinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185476 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216326_2_v_0_sulodexide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48116 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.32732 Rough endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.918 Parasubiculum, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1082 K562_PJ34_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149102 CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.4491 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A705-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PLZ5-1126-SM-3P613 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04608 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.839873 ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GRANTA519 CCLE Cell Line Gene CNV Profiles -1.0 -1.65567 RPMI-8226 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.21336 GTEX-XOTO-0011-R9A-SM-4GICI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839363 CEBPB ChEA Transcription Factor Targets 1.0 null A549_Barasertib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014456 intermediate stratum of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87714 HS-SULTAN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.93467 K562_PJ34_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170604 Vitelline membrane TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.802 YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9682_UTP15_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.734411 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-224 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.74429 ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9557 GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34804 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.967389 YD-38-CI01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206374 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null anteroventral nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.39603 NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.868445 MCF7_Pelitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148737 GSE217132_0_v_1_pfkfb4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEx Muscle 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures -1.0 -17.9169 EB2 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.89726 Lateral hypothalamic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0746 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02919 AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21043 NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.82063 hsa-miR-25-3p MiRTarBase microRNA Targets 1.0 null E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null zbtb8os GeneRIF Biological Term Annotations 1.0 null CYB5D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07095 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Bisindolylmaleimide IX_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180542 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00638 J82 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.36168 GSE252857_1_v_0_prednisone_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KPNRTBM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.88598 r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35235 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.61747 posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00724 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Busulfan_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140282 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Costunolide_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.021953 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F1-26619117-HEPATOCYTES-MOUSE-LIVER ChEA Transcription Factor Targets 2022 1.0 null retrosplenial cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08118 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1 ChEA Transcription Factor Targets 1.0 null nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 NRSN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25668 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977895 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.906191 GSE148200_3_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04181 TAF7 ENCODE Transcription Factor Targets 1.0 null USF1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null estradiol_homo sapiens_gpl570_gse23610 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54954 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CBLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7169 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11777_KO_Acot4_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.30219 macromolecular complex GO Cellular Component Annotations 2015 1.0 null K562_Rucaparib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0292088 CACO-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.863429 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R2B-SM-4AT5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03831 RNA cap binding complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.912 Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.543918 superficial stratum of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36488 rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.267198 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRMT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04959 C2CD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00307 GTEX-S7SE-0005-SM-2XCEA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28606 RAD21 ENCODE Transcription Factor Targets 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1138 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41207 GSE216043_11_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null 7501_RPS13_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.535051 CBX3 ENCODE Transcription Factor Targets 1.0 null K562_Altretamine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0203836 GTEX-P4PQ-0526-SM-2HMKR GTEx Tissue Sample Gene Expression Profiles 1.0 1.07492 GSE80537_5_v_2_adhfe1_human RummaGEO Gene Perturbation Signatures -1.0 null MYC-19079543-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34454 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SPIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5709 primary auditory cortex (core)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.990343 cell part LOCATE Predicted Protein Localization Annotations 1.0 null K562_Daphnetin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0308664 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102757_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null intermediate stratum of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21666 Fatty acid beta-oxidation multienzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.948 A172_CENTRAL_NERVOUS_SYSTEM CCLE Cell Line Proteomics 1.0 3.72801 FARSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21111 dorsal motor nucleus of the vagus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.99165 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE119978,GSE180930_6_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1 Rummagene Transcription Factor Associations 2026 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48717 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114232_10_v_6_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rna processing GO Biological Process Annotations 2015 1.0 null KPNRTBM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.84824 USF2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Capecitabine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0260764 GSE151782_6_v_5_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_PD98059_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147819 Neurosphere_Cultured_Cells_Cortex_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.06009 GTEX-N7MT-0007-SM-3GACQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40269 GFER Pathway Commons Protein-Protein Interactions 1.0 null SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.922262 GSE233183,GSE233187_3_v_6_larp1_human RummaGEO Gene Perturbation Signatures -1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null r10 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36427 Primary somatosensory area, barrel field, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11127 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.985434 496100408_PCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.43662 GSE227592_9_v_3_adar_human RummaGEO Gene Perturbation Signatures 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MIR34_OE_GDS2755_645_human_HCT116 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null K562_Costunolide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.029576 H2AFZ ENCODE Transcription Factor Targets 1.0 null ventral premammillary nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12405 PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04897 hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.31281 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68G-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RD-90-DS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250026 PL-21 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.729 bone marrow HPA Tissue Protein Expression Profiles 1.0 1.49892 plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.208632 K562_BRD4770_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0238166 UBTF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SKNMC_BONE CCLE Cell Line Proteomics 1.0 3.52313 Perturb_4518_Mut_Tip60/Ep400_SRP081300 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.21308 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152432_1_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE183271_4_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null binding GO Molecular Function Annotations 2015 1.0 null HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.998475 5733_NOL11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.52155 VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35725 SLC35B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32384 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2735 GTEX-R55E-0006-SM-2TC5G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24884 PPARG ChEA Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A510-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05524 GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78788 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.07814 GTEX-X4LF-0526-SM-3NMB6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.9975 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.274844 PAR polarity complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.68 PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null GSE202434,GSE202438_6_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEx Brain 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 8.46249 CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59272 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.68523 substantia innominata/basal nucleus, transitional part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10289 YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.943172 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72257 Bed nuclei of the stria terminalis, posterior division, transverse nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12941 POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE-26-XS06_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.304055 TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE199921_1_v_0_romidepsin_mouse RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Busulfan_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200386 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S32W-0326-SM-2XCBI GTEx Tissue Sample Gene Expression Profiles 1.0 0.919132 dorsolateral prefrontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35379 GSE62843,GSE64371_2_v_3_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.88591 SP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153836_11_v_9_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null SHISA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38454 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE227891_5_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02969 GATA3_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr1_32629236_C_T_b38 GTEx eQTL 2025 1.0 1.60755 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_10_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null Xeroderma pigmentosum DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.134 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Ellagic acid_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185399 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0969 10040_ZCCHC9_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.567934 posteroventral (inferior) parietal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.946617 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3916 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 EF-80-OD07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.347919 PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null K562_Dasatinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0260818 FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Arbuscule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.154 A549_Disulfiram_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148969 SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_10365_KD_Setd2_SRP184682 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.55806 ENY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38728 GSE203158_5_v_14_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.98319 GSE108675_3_v_0_slc1a4_mouse RummaGEO Gene Perturbation Signatures 1.0 null 5734_NOL12_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.584172 H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null K562_INO-1001_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0287152 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.49805 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152937_6_v_5_slc16a13_mouse RummaGEO Gene Perturbation Signatures -1.0 null 8744_TBRG4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.549775 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ME-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null Perturb_4941_KO_Prdm14_SRP061948 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.04892 Anterior olfactory nucleus, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45054 MCF7_A-366_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159779 periventricular stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83982 K562_Divalproex Sodium_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172192 Weight Gain CTD Gene-Disease Associations 1.0 1.25432 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XAJ8-0526-SM-47JYK GTEx Tissue Sample Gene Expression Profiles 1.0 1.02356 Neuronal ceroid lipofuscinosis 10 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.113 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149075_6_v_5_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null mRNA cap binding complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.876 FOXA1 ENCODE Transcription Factor Targets 1.0 null TAF1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0011-R9A-SM-32QOZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863186 MRPL23 Pathway Commons Protein-Protein Interactions 1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null 7456_RPL28_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.643881 FOXM1-26100407-CHIP-SEQ-HEK293-FLP-IN-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.80063 GTEX-NL3H-0011-R6a-SM-2I3G8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.877077 PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR Rummagene Transcription Factor Associations 2026 1.0 null cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.8411 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles 1.0 1.80076 PMC11216188-peerj-12-17616-s013.pdf-8-ZBTB8A_ZBTB8A Rummagene Transcription Factor Associations 2026 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3728595-srep02327-s1.pdf-18-KDM2B_KDM2B Rummagene Transcription Factor Associations 2026 1.0 null 6050_PAM16_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.632816 GTEX-WHSE-3126-SM-3P5ZI GTEx Tissue Sample Gene Expression Profiles 1.0 0.981275 K562_Tie2 kinase inhibitor_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156202 TFEB-21752829-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null K562_G007-LK_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0182387 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.52952 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24839 GTEX-RNOR-0011-R9A-SM-2TF52 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.991353 K562_A-366_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0245792 K562_Quercetin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0182991 GTEX-WYJK-0005-SM-3NMA1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04591 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30955 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBED2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7409 Tuberomammillary nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.62016 PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27487 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80Q-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17238 SARS-CoV MA15_Day1-PFU-10^4_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.82974 PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MCF7_Linifanib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0226932 Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Roxadustat_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.014197 GTEX-T8EM-1026-SM-3DB7M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03094 GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872711 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.967869 temporal muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.08184 MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Ki16425_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0188075 primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08153 GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92671 GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles 1.0 2.19366 Ventral premammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03086 GTEX-X585-0011-R5A-SM-46MVI GTEx Tissue Sample Gene Expression Profiles 1.0 0.872933 GSE108614,GSE108615_3_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null 2225_UTP25_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.514874 FLI1 ChEA Transcription Factor Targets 1.0 null GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66045 GTEX-WFG8-0926-SM-3GIKJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.22106 HS 895.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02209 mantle zone of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36738 SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.865177 PACC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0983 Aortic root TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.192 K562_PHA-680632_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0134235 SP2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Aurora A Inhibitor I_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0169195 r1 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23197 NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null Perturb_8893_OE_YAP1_SRP151027 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.53263 ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4501-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_BMS-536924_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0205048 E2F4-21247883-LYMPHOBLASTOID-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null mammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21393 raphe nuclei of medulla Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.890743 GSE220520_3_v_4_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.14641 GTEX-Q2AI-0826-SM-48TZO GTEx Tissue Sample Gene Expression Profiles 1.0 1.01491 motor nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2622 7444_RPL19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.651368 REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null KARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88446 CMAH_KO_GDS4200_114_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null caudal group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.986639 GTEX-OOBJ-2026-SM-3NB1R GTEx Tissue Sample Gene Expression Profiles 1.0 0.979304 CAL33_UPPER_AERODIGESTIVE_TRACT CCLE Cell Line Proteomics 1.0 2.64847 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20512 Perturb_5266_KD_neg_SRP331021 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.59479 CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220511 GTEX-N7MS-2326-SM-2HMLD GTEx Tissue Sample Gene Expression Profiles 1.0 1.1586 mantle zone of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57466 SUPHD1 CCLE Cell Line Gene CNV Profiles -1.0 -1.9111 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles 1.0 1.97028 CA4 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.23113 tRNA (m7G46) methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.849 H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_PD173074_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184498 HOXB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.8558 GSE152432_6_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_UNC0379_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0183714 r9 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43146 rna GeneRIF Biological Term Annotations 1.0 null K562_TG101209_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0202884 primary motor cortex (area M1, area 4)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.32728 TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7479_RPL7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.643481 Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_4940_KO_Cbfa2t2_SRP061948 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.37305 GSE231648_1_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC4944136-srep28995-s2.xls-NOBOX-gene_NOBOX Rummagene Transcription Factor Associations 2026 1.0 null Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.95724 NCIH209 CCLE Cell Line Gene CNV Profiles 1.0 2.36174 K562_WP1066_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0195285 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null RA-49-ZB08_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201036 GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903404 DNA replication factor A complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.803 MAX_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IC-05-AW29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.337926 posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.53934 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.968087 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null striatum_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.977785 K562_Obatoclax Mesylate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177305 PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null GBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33924 MAFF ENCODE Transcription Factor Targets 1.0 null membrane-bounded vesicle GO Cellular Component Annotations 2015 1.0 null AP1M2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09519 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_2day-MOI-10^4_None_GSE44441 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.87196 DRGX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31176 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H3118 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.63864 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null GTEX-XK95-0226-SM-4AT58 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830784 K562_MK-0752_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0242147 K562_Entacapone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0304265 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52595 GTEX-WXYG-2326-SM-4E3I6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871923 ZSCAN31 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.4506 periventricular stratum of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17189 TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RT-112 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.11418 CTCF_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endometrium_4b HPA Tissue Sample Gene Expression Profiles -1.0 -0.921032 GSE217776,GSE217829_2_v_6_sgf29_human RummaGEO Gene Perturbation Signatures 1.0 null Ribonuclease P complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.153 pyramidal layer of IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3582 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.946397 MF-41-QM60_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.430053 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE228727_2_v_1_dapagliflozin_mouse RummaGEO Drug Perturbation Signatures -1.0 null E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55D-0926-SM-3GAEU GTEx Tissue Sample Gene Expression Profiles 1.0 0.86691 intermediate (interpositus) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02438 EIF4A3 Pathway Commons Protein-Protein Interactions 1.0 null A549_Divalproex Sodium_10然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144128 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.0727 intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18923 10015_ZBTB8OS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.906354 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841636 extracellular vesicular exosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 REST_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852488 Perturb_66_OE_Zscan4_SRP252595 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.16592 GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22823 PPARG-20887899-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles 1.0 1.21973 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.292053 biological_process GO Biological Process Annotations 2015 1.0 null HT-3 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.52181 K562_Azacitidine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0190254 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_7351_KD_SFPQ_SRP281189 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.45629 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.53652 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146840,GSE146842_3_v_2_qrich1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA-42-YI34_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.60345 Perturb_13518_KD_ILF2_SRP077068 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.26168 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MC-40-IP75_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.343275 CARD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25968 MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-19079543-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34182 MCF7_Entinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00891306 A549_Fulvestrant_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172928 GTEX-QLQW-0226-SM-447BJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.16845 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13196 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Regorafenib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0526995 Perturb_5112_KD_Med10_SRP325525 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.30881 MCF7_Tie2 kinase inhibitor_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0201103 REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GRHL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7151 CEBPD ENCODE Transcription Factor Targets 1.0 null I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.991061 K562_Alendronate sodium trihydrate_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0213424 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01745 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3086_FIP1L1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.514924 MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36894 superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1688 SPI1-22096565-GC-B-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-1726-SM-4B65W GTEx Tissue Sample Gene Expression Profiles 1.0 0.882314 GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52989 ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4674 4472_KRR1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.544082 MCF7_Nilotinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0227523 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.23649 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 EIF5B Pathway Commons Protein-Protein Interactions 1.0 null SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00599 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.11445 GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles 1.0 1.42579 GTEX-WFG8-0001-SM-4LVN8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.61246 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.22742 Divisome complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.089 PRRX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01593 GTEX-WFON-0001-SM-3P61W GTEx Tissue Sample Gene Expression Profiles 1.0 1.71278 embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.28022 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FB-32-PY27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203248 GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Roxadustat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162193 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.35214 sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.570409 NFIC_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null retromammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42205 A549_Selisistat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0136051 K562_SB431542_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137701 HUP-T4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.826037 K562_Cerdulatinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187358 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Roscovitine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0123324 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1_G1E-ER4_mm9_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5K2-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver GTEx Tissue Gene Expression Profiles -1.0 -0.898719 BORCS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11824 plexiform layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59827 icSARA deltaORF6_7Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.06655 MCF7_Mocetinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00837522 SKNBE2 CCLE Cell Line Gene CNV Profiles -1.0 -1.47385 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82742 GSE140997_4_v_3_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null K562_PD173074_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.019417 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28158 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF3 ChEA Transcription Factor Targets 1.0 null MCF7_AZD1480_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147852 POLR2AphosphoS5_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lateral septal nucleus, rostral (rostroventral) part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16959 layer V of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.8506 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.981706 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950001 hsa-miR-4760-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE167324_2_v_0_eif4e_mouse RummaGEO Gene Perturbation Signatures -1.0 null Inferior colliculus, dorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78713 DD-43-WW40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209982 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.901047 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.8378 SPI1 ChEA Transcription Factor Targets 1.0 null EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.68075 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16194 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.935631 MCF7_Maraviroc_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014281 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.399032 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Tuberomammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.68354 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE84922,GSE84924_4_v_1_sall4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15515 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-2626-SM-33HC9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.889335 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.55252 GTEX-XLM4-3126-SM-4AT6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.51389 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Filgotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0225648 outer SZ in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.852568 496100430_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03134 ATM_knockout_74_GSE23116 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.43571 NFYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8755 NHERF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04729 H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE120612_6_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZR75B Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.988622 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27344 EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HC-01-FD24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201733 lateral preoptic nucleus, PO2 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82072 KLE CCLE Cell Line Gene CNV Profiles 1.0 1.48623 brain_3b HPA Tissue Sample Gene Expression Profiles -1.0 -1.48898 GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10977 POLR2A_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WI4N-2726-SM-3LK7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14378 GSE131649_6_v_7_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null 496100337_HIP_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.14742 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Entinostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.022443 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.51976 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.29631 PMC8554124-DataSheet2.XLSX-34-RFX3_RFX3 Rummagene Transcription Factor Associations 2026 1.0 null 6493_PNO1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.549799 GATA2_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Avagacestat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0128634 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03357 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 9841_WDR75_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.565309 FOXR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00474 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ZBTB33_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1278 Perturb_773_Mut_ACLY_SRP403241 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.54364 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.730542 MCF7_KW-2449_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0135932 Mitochondrial fatty acid beta-oxidation multienzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.951 RUNX3 ENCODE Transcription Factor Targets 1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.33997 GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles 1.0 0.96866 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2453 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13235_KO_Tfe3_SRP126727 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.91275 GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles 1.0 2.85955 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11335 NLGN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47948 ZBTB33 ENCODE Transcription Factor Targets 1.0 null A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.57924 K562_MLN8054_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0277201 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.998437 Inward rectifier potassium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.958 GSE81193_1_v_2_irf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null 9804_WDR12_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.811855 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null H3K4me1_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HES3_KO_GSE64449_186_mouse_Min6 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10474 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SFPI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DCXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04001 POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFM192A_BREAST CCLE Cell Line Proteomics 1.0 3.52313 GSE192771_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null rostral group of intralaminar nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.845664 AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null GSE165682_2_v_1_ptbp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X5EB-2226-SM-46MW4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857106 CHD2 ENCODE Transcription Factor Targets 1.0 null Perturb_5096_KO_Cbx1/Cbx3/Cbx5_SRP104194 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.84906 MAX_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.88962 BCLAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876885 GATA2 ENCODE Transcription Factor Targets 1.0 null K562_PF-3845_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.030446 UBC Pathway Commons Protein-Protein Interactions 1.0 null STAT3 ChEA Transcription Factor Targets 1.0 null SOX2-21211035-LN229-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-R53T-0426-SM-48FEM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938172 SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.982428 CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null REST_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17065 NRF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JW-1126-SM-4DM5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.47686 superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76468 SULT1A2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17708 TAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22601 ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOLT-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null K562_Cimetidine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0248695 CTNNBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1313 GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890852 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Parasubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63816 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0517 PMC12673788-12967_2025_7484_MOESM5_ESM.xlsx-OCT4_cor_p_0_4-gene_name_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02247 USF2_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31611 GTEX-QLQW-0326-SM-447A8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03544 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SSA3-0002-SM-3P61R GTEx Tissue Sample Gene Expression Profiles 1.0 3.54038 EP300 ENCODE Transcription Factor Targets 1.0 null PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-10_names_TP53 Rummagene Transcription Factor Associations 2026 1.0 null PU.1-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K79me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE192771_2_v_1_mt1g_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65865 PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3 Rummagene Transcription Factor Associations 2026 1.0 null A549_Sorafenib Tosylate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0208897 CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.812651 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36423 GSE112765,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_EED226_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160895 superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04286 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE183271_2_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.4818 GSE102675_3_v_0_atf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_5023_KO_4930500J02Rik_SRP072189 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.34456 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.980623 IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.605464 K562_YM155_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0185892 H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null layer 4 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24909 DACH1 ChEA Transcription Factor Targets 1.0 null OTX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5615 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE151782_2_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5072-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-POMQ-0526-SM-3GADD GTEx Tissue Sample Gene Expression Profiles 1.0 0.836096 E2F4 ENCODE Transcription Factor Targets 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42174 primary auditory cortex (core)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01094 GTEX-U3ZG-0001-SM-47JYF GTEx Tissue Sample Gene Expression Profiles 1.0 1.71194 GSE217541,GSE217543_0_v_2_tet1_human RummaGEO Gene Perturbation Signatures 1.0 null AC-30-XU83_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221148 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.68042 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.16908 GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.4192 639-V COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC1937 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.824381 GSE62843,GSE64370_4_v_3_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE138818_1_v_0_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.97091 SK-MEL-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31625 Carbon phosphorus lyase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.024 ATF3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_Ramelteon_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0202367 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.912486 PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null CEBPB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Flavopiridol HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0107128 K562_Veliparib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171032 K562_Lapatinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156521 CREBBP ENCODE Transcription Factor Targets 1.0 null lateral portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05978 USF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null c211 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.203 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC10247733-41408_2023_863_MOESM2_ESM.pdf-562-ZBTB26_ZBTB26 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE172146_2_v_1_mettl1_human RummaGEO Gene Perturbation Signatures 1.0 null SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4269 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null 33_ABCF1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.584401 C6orf203 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-Q2AI-1326-SM-2S1PL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03378 GSE186223,GSE186224_6_v_3_hmces_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCFL ENCODE Transcription Factor Targets 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.80092 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6870_PSMD2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.72714 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4813_KO_Apex1_SRP193096 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.76199 SNU899 CCLE Cell Line Gene Expression Profiles -1.0 -2.24366 FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.299536 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H747 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.95927 GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERRalpha_Deficiency_GDS2727_646_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.47472 Insect tracheal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.159 medial amygdala, anterodorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58811 GSE205163,GSE205164_5_v_8_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null r2 part of the trigeminal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36488 PMC12513837-41588_2025_2336_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_List_of_AR-only_and_p300_AR-shared_enhancer_regulated_genes_AR Rummagene Transcription Factor Associations 2026 1.0 null MYCN-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74814 KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.833499 ventrolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.903007 CAL78 CCLE Cell Line Gene CNV Profiles 1.0 1.58758 Perturb_13196_KO_Dax1_ERP127280 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.12509 intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 nucleus GO Cellular Component Annotations 2023 1.0 null GPX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33651 6555_POLR3A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.777464 SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17441 MCF7_S3I-201_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185537 r8 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.45849 p3 portion of paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30203 GTEX-Q2AG-1026-SM-33HBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08837 A549_CUDC-101_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164296 KP-N-RT-BM-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.2607 intermediate part of StrSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57256 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XXEK-1726-SM-4BRVB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24157 AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null K562_Lenalidomide_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0210064 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12877 GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78892 ACOT11 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0791 SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QCQG-0526-SM-48U2A GTEx Tissue Sample Gene Expression Profiles 1.0 0.981325 rna splicing, via endonucleolytic cleavage and ligation GO Biological Process Annotations 2015 1.0 null EIF4ENIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2397 trna processing GO Biological Process Annotations 2015 1.0 null GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.061 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EK-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null NCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151612_4_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null ligase GeneRIF Biological Term Annotations 1.0 null MCF7_PD98059_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0211169 FLI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06683 CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null proteasome accessory complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.259837 DACH1-20351289-MDA-MB-231-HUMAN ChEA Transcription Factor Targets 2022 1.0 null REST ENCODE Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890993 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Crizotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146215 SARS-CoV MA15_Day4-C57BL-6_None_GSE40824 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.86515 HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28907 Perturb_2829_OE_IGF1R_SRP064353 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.76768 GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36443 GTEX-QDVN-1126-SM-48TZ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10201 GTEX-W5WG-1426-SM-4KKZP GTEx Tissue Sample Gene Expression Profiles 1.0 0.837546 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.94923 Lung squamous cell carcinoma_LUSC_TCGA-33-6738-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null extracellular vesicle GO Cellular Component Annotations 2015 1.0 null GSE119978,GSE180930_0_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null 2792_EXOSC5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.549895 COLO678_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 3.99786 GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30455 H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1195 CCLE Cell Line Gene Expression Profiles 1.0 1.57875 K562_Selisistat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0229325 inferior colliculus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.859487 layer 3 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8582 intermediate stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82172 trna GeneRIF Biological Term Annotations 1.0 null 8405_SRFBP1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.638441 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.899733 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lmx1b_18351676_hind_limb_bud_lof_mouse_gpl1261_gds3320 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.153073 GTEX-X88G-0126-SM-47JZ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843653 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68205 MCF7_Cimetidine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0133513 FSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63881 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null GSE135352_2_v_3_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null Dorsal motor nucleus of the vagus nerve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2112 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SF-0001-SM-3K2BE GTEx Tissue Sample Gene Expression Profiles 1.0 1.01064 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null K562_Dacinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0252209 NUDT18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08579 primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10416 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE158815_1_v_3_trib1_mouse RummaGEO Gene Perturbation Signatures -1.0 null A549_Sodium Phenylbutyrate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180404 HMGN3 ENCODE Transcription Factor Targets 1.0 null PMC11328671-jitc-12-4-s003.pdf-438-ZBTB12_ZBTB12 Rummagene Transcription Factor Associations 2026 1.0 null AGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20875 trna-splicing ligase complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null K562_Cimetidine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0192681 GSE110178_1_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null intracellular part GO Cellular Component Annotations 2015 1.0 null Tympanum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.647 SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.13761 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-VN-1203-2004(H5N1)_Day1-10^4pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.7919 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30388 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67A-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-KT-A7W1-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Clathrin coat of trans-Golgi network vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.738 GATA6-21074721-CACO-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HOXB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2251 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE172295_0_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.3144 CACO2 CCLE Cell Line Gene CNV Profiles -1.0 -1.35326 NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.41884 K562_EED226_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0327849 GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 0.830192 inner CP in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10782 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null K562_BMS-265246_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180099 Lung adenocarcinoma_LUAD_TCGA-50-6597-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.21951 HNF4A ChEA Transcription Factor Targets 1.0 null JIYOYE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31316 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.50846 mantle zone of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10036 GTEX-T5JC-0011-R9A-SM-32PLV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.922281 GTEX-WCDI-0002-SM-3P61U GTEx Tissue Sample Gene Expression Profiles 1.0 1.99589 GSE186660_2_v_1_nicotine_mouse RummaGEO Drug Perturbation Signatures 1.0 null MRPL22 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QDVN-0726-SM-4B64L GTEx Tissue Sample Gene Expression Profiles 1.0 0.876351 MCF7_Amisulpride_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0283219 Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22132 A549_JQ1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147521 C2BBE1 CCLE Cell Line Gene CNV Profiles -1.0 -1.64676 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.77205 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.9214 inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.96909 GTEX-XYKS-0526-SM-4BRW2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21883 4108_IMP4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.548776 ELK4 ENCODE Transcription Factor Targets 1.0 null GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.35879 TGBC24TKB Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.96239 corticoid layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5991 GTEX-OHPK-0526-SM-2HMJB GTEx Tissue Sample Gene Expression Profiles 1.0 0.863328 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.857798 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null GTEX-SNMC-1226-SM-2XCFP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01402 NFATC1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02184 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.27967 GSE88819_3_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ML-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.772 PHF8-20622853-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null DE-34-DT75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.706753 yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.751968 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Signal recognition particle, endoplasmic reticulum targeting COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.79 Sarcoma_SARC_TCGA-MB-A5Y8-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE220520_3_v_9_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null tRNA splicing, via endonucleolytic cleavage and ligation GO Biological Process Annotations 2023 1.0 null striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18986 ZBTB7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42548 anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31903 7509_RPS19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.513954 GSE149123,GSE149128_1_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null 2543_EIF2S3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.58159 lateral nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00949 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.856277 vesicle GO Cellular Component Annotations 2015 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2B ENCODE Transcription Factor Targets 1.0 null nd7/23 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.652 NKX6-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.4488 Perturb_4276_KO_Smad2/Smad3_SRP132215 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.6697 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null WBP1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35921 AD-51-FB60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.960793 SKES1 CCLE Cell Line Gene Expression Profiles 1.0 1.39945 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TRIM28 ENCODE Transcription Factor Targets 1.0 null K562_Tranylcypromine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0275121 posteroventral (inferior) parietal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50755 anterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14158 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PSME4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18027 PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521 Rummagene Transcription Factor Associations 2026 1.0 null GSE199255,GSE199356_3_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Cediranib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151214 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.45099 inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20248 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A549_Ki8751_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179641 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A119-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GFI1B ChEA Transcription Factor Targets 1.0 null SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.06322 KAT2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Selisistat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171112 STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_BMS-265246_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0100299 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MZ in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.914225 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.963294 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.105 5927_OGDH_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.542933 K562_SB431542_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0324751 layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.88098 GSE147613_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBC1_LUNG CCLE Cell Line Proteomics 1.0 4.78946 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.764347 NDUFB4 Pathway Commons Protein-Protein Interactions 1.0 null retromammillary area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37254 Stalk cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.72 SFPI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.11843 PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null GSE202434,GSE202438_8_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null t61-colon_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.42622 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE165122_2_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF254_01_127 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.34435 Perturb_5378_KO_Ago2_SRP178473 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.01528 Perturb_1776_OE_Casr_SRP386468 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.73222 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.7522 GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87388 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PMPCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05352 VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14371 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.846719 ventral tuberomammillary nucleus, superficial part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0281 GSE252857_2_v_3_klf15_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE165122_0_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Ku-DNA ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.74 Prostate adenocarcinoma_PRAD_TCGA-J4-A67L-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE183251_4_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KLF4-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null Nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.53066 Perturb_16573_KO_Grn_SRP070944 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.61332 Auditory vesicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.948 Cortical amygdalar area, posterior part, lateral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2582 GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30068 TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X62O-0826-SM-46MW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84474 GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.952971 Perturb_11774_KO_48J19Rik_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.11029 MCF7_Sorafenib Tosylate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139179 HNFA-21074721-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.18286 Perturb_409_KO_IRE1_SRP353826 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.573 K562_ABT-737_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175519 icSARS CoV_7Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.94106 GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93471 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13275_KO_Zbtb24_SRP198761 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.35877 vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 DHX58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77688 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.51805 7475_RPL5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.532485 FEV JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.1305 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null brain HPA Tissue Gene Expression Profiles -1.0 -0.834756 primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.984162 GSE197562_2_v_3_nox4_mouse RummaGEO Gene Perturbation Signatures -1.0 null III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.892269 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE122101,GSE122103_3_v_1_ssu72_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-204 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 MYCN-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GSE228181_0_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2BK15ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.492 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.947563 j111 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.353 SB-29-ZH97_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.29447 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XMK1-0126-SM-4B65F GTEx Tissue Sample Gene Expression Profiles 1.0 0.961295 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06723 NCIH1693 CCLE Cell Line Gene Expression Profiles 1.0 2.14295 DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.313784 POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9443_TWISTNB_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.759487 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.931089 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Osteoporosis DisGeNET Gene-Disease Associations 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SUCS-0626-SM-32PM5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15225 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA2-19941826-K562-human ChEA Transcription Factor Binding Site Profiles 1.0 null A-VN-1203-2004(H5N1)_Day1-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.15866 PMC3371315-NIHMS350140-supplement-8.xls-MCF7-T47D-SK-453_Down_MCF7-T47D-Supplementary_Table_1_ER-positive_FOXA1_signature_Genes_decreased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADAMTS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03354 K562_Toremifene Citrate_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178815 lateral part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2172 c-MYC_KD_GDS2526_112_human_MCF-7 BREAST CANCER cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.571 H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null K562_Curcumin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176712 Dorsal nerve cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.052 K562_Divalproex Sodium_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0327446 BATF ENCODE Transcription Factor Targets 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PMC5031867-mmc2.xlsx-RYTTCCTG_V_ETS2_B-GENE_SYMBOL_ETS2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PWOO-0926-SM-2I3EC GTEx Tissue Sample Gene Expression Profiles 1.0 1.07361 E2F4-21247883-LYMPHOBLASTOID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null K562_Lenalidomide_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0186014 YY1-33199912-293T-HUMAN-KIDNEYEMBRYO ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Selisistat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016923 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_17683_KO_Parp1/Parp2_SRP311978 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.41311 K562_Disulfiram_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152901 VD-41-XP62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.32291 YY1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A40G-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Tacedinaline_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00905151 GTEX-S3XE-1726-SM-3K2AM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970663 Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null GSE87862_0_v_1_mov10_mouse RummaGEO Gene Perturbation Signatures 1.0 null POU3F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8787 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E1-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACA DeepCoverMOA Drug Mechanisms of Action 1.0 0.32 T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24 GSE247862,GSE247863_4_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null periventricular stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.35811 6534_POLR1B_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.906033 SUGT1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.58371 PRMT1 Pathway Commons Protein-Protein Interactions 1.0 null BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV MA15_Day1-PFU-10^5_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.90225 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7454_RPL27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.49598 K562_Cimetidine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0199526 K562_Sodium Phenylbutyrate_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144167 GTEX-TKQ1-1026-SM-4GICL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853678 NCCIT Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.15574 GTEX-P4PQ-1526-SM-3NMCK GTEx Tissue Sample Gene Expression Profiles 1.0 1.11696 A549_TMP195_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142156 Brain - Cerebellar Hemisphere GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.828327 THAP1 ENCODE Transcription Factor Targets 1.0 null VDR ChEA Transcription Factor Targets 1.0 null POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null corticoid layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61125 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATM_knockout_75_GSE23116 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.86239 Perturb_22_OE_Carhsp1_SRP217699 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.54971 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 K562_Thiotepa_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148294 GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7438_RPL14_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.878376 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.97711 GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40748 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Congenital contractural arachnodactyly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.428 A549_ABT-737_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141095 MCF7_Pracinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0102602 Anterior olfactory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.18278 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-VN-1203-2004(H5N1)_Day1-10^3pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.85601 SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null nucleus of the stria terminalis, medial division, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08942 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE62843,GSE64371_4_v_3_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08092 Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.25711 HOXB7-26014856-BT474-HUMAN ChEA Transcription Factor Targets 2022 1.0 null USF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860035 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7024 plastid-encoded plastid RNA polymerase complex B COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.696 K562_PJ34_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0354131 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null GSE88819_5_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.899733 Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17745 K562_Cerdulatinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0296801 Dorsal peduncular area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08866 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7871-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Ofloxacin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153559 neural crest TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.541377 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_2506_KD_NXF1_SRP226431 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.64687 K562_AG-490_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0218997 H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null tonsil_8b1 HPA Tissue Sample Gene Expression Profiles 1.0 1.96376 GATA6-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE199255,GSE199356_4_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null AA-67-TF79_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20989 VZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.872822 Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Linifanib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.028052 ERCC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33657 striatal part of olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43214 MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03989 Perturb_11611_KD_BRD8_SRP113334 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.26555 r10 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01589 MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNF2 ENCODE Transcription Factor Targets 1.0 null GSE210885_0_v_7_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.79016 Perturb_13273_KO_Spen_SRP198728 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.53813 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.1618 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7287-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16153 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.23523 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C9orf142 Pathway Commons Protein-Protein Interactions 1.0 null GSE217541,GSE217543_3_v_2_tet1_human RummaGEO Gene Perturbation Signatures 1.0 null YY1_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-0426-SM-32PLO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17473 GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7450_RPL23_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.704548 HDAC2 ENCODE Transcription Factor Targets 1.0 null GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles 1.0 1.87698 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Cervical Neoplasms CTD Gene-Disease Associations 1.0 1.11571 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125782_0_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.241779 bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -0.855111 PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Temporal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14004 MCF7_Amisulpride_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0210902 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6492_KO_Atrx_SRP323952 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Central amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00508 5163_MPHOSPH10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.555107 NCIH209 CCLE Cell Line Gene Expression Profiles 1.0 1.80891 K562_XAV-939_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0218676 GSE88819_6_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Toremifene Citrate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0196504 Depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.01 PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 1.78652 6219_PES1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.583701 NFATC1 ENCODE Transcription Factor Targets 1.0 null K562_TMP195_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179759 tunica intima vasorum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.541773 neural plate TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.165924 2113_DDX24_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.570378 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A549_Pelitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175107 A549_Navitoclax_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016482 GSE110178_5_v_6_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38155 Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09826 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_11838_KO_Slc6a14_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.38915 Infralimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77128 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Endonuclease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.213 YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02083 K562_PD173074_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171662 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.16561 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_1_GSC Rummagene Transcription Factor Associations 2026 1.0 null DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.868445 GTEX-PWN1-0726-SM-48TDR GTEx Tissue Sample Gene Expression Profiles 1.0 0.879888 periventricular stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06201 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null called GeneRIF Biological Term Annotations 1.0 null Perturb_15705_KO_Rnf20_SRP304263 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.53994 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.841744 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2A ENCODE Transcription Factor Targets 1.0 null Perturb_5114_KD_Med12_SRP325525 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.20462 plexiform layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.24506 GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870754 GSE242290_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4841-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.973219 YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sporophyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.57 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-POYW-1326-SM-48TCG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833197 GTEX-XGQ4-0004-SM-4AT5S GTEx Tissue Sample Gene Expression Profiles 1.0 1.67102 dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02177 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.900489 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120612_4_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles 1.0 1.42671 Central cylinder COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.727 CCND1 ChEA Transcription Factor Targets 1.0 null TE-6 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.68545 GLYATL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48798 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null dorsal motor nucleus of the vagus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.78434 Lateral septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00992 COG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24009 GTEX-OXRP-2426-SM-2S1NR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91279 cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null GSE137144_3_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POYW-0006-SM-2XCF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46119 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50132 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1_G1E-ER4_mm9_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30201 Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null fasciola cinerea Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01203 GSE198434_1_v_0_aspirin_human RummaGEO Drug Perturbation Signatures -1.0 null A549_Divalproex Sodium_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152598 A549_Curcumin_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164536 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE131649_2_v_8_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null A549_ABT-737_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0138419 GATA3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YW-0126-SM-3LK6D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03197 GTEX-NFK9-2226-SM-3MJGP GTEx Tissue Sample Gene Expression Profiles 1.0 1.13801 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rectum_8c HPA Tissue Sample Gene Expression Profiles 1.0 0.970471 KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.949105 MCF7_Rucaparib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0254587 BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4849_KD_ZEB2_SRP059197 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.79027 GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles 1.0 1.69162 GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69302 RBPJ-21746931-IB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MF-81-RJ18_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328515 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of the IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35651 EFF-1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.63 GTEX-WHPG-0004-SM-3NMDO GTEx Tissue Sample Gene Expression Profiles 1.0 1.66177 FOXM1 ENCODE Transcription Factor Targets 1.0 null USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Opioid Use DisGeNET Gene-Disease Associations 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.59955 GTEX-O5YT-1426-SM-3MJHC GTEx Tissue Sample Gene Expression Profiles 1.0 1.21215 Mlg TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.554 CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08779 RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U3-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CUX1 ENCODE Transcription Factor Targets 1.0 null NFYB ENCODE Transcription Factor Targets 1.0 null Perturb_13268_KO_chr2_SRP162484 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.29403 RELA_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVN-1326-SM-48TZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01339 A549_Ellagic acid_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153478 Condition, Preneoplastic DisGeNET Gene-Disease Associations 1.0 null Skin BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.839823 GTEX-S7SF-0226-SM-3K2BI GTEx Tissue Sample Gene Expression Profiles 1.0 0.859472 CEBPB-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17163 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.30344 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00432 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C8-06A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null 7424_RPAP3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.630746 HOXB4-20404135-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.937689 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Barasertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0222887 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.65642 6328_PIF1_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.608002 H3K4ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.906414 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.680595 STK11_knockout_278_GSE34866 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.65699 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCGF4-22325352-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_12130_KO_Ldb1_SRP136181 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.68081 GTEX-XQ8I-1726-SM-4BOQB GTEx Tissue Sample Gene Expression Profiles 1.0 1.14928 ML221 DeepCoverMOA Drug Mechanisms of Action 1.0 0.34 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB175VII CCLE Cell Line Gene CNV Profiles -1.0 -1.42066 GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.46073 CREBBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06344 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null ZEB1 ENCODE Transcription Factor Targets 1.0 null GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 0.915691 heterocycle metabolic process GO Biological Process Annotations 2015 1.0 null DIAPH1 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leukemia_promyelocytic-HL-60 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.24565 EZH2 ENCODE Transcription Factor Targets 1.0 null Perturb_13126_KO_Kap1_SRP065215 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.45867 CHDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05858 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Zfp961 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.1283 GABP-17652178-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null spi1_17041602_preleukemic_hscs_lof_mouse_gpl1261_gds2411 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.09985 PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB Rummagene Transcription Factor Associations 2026 1.0 null PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Upregulated-Gene_name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEW-0002-SM-4AT5O GTEx Tissue Sample Gene Expression Profiles 1.0 1.60637 layer 5 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09763 H3K27ac_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Alisertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161397 CTCF ENCODE Transcription Factor Targets 1.0 null GSE226316_0_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lung_4b HPA Tissue Sample Gene Expression Profiles -1.0 -1.06022 TF-77-DW08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221914 Down Syndrome_Fetus_GSE10758 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.87947 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89954 PMC7777191-pnas.2007991117.sd03.xlsx-E2F1_Q6-PROBE_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Bisindolylmaleimide IX_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0222341 8MGBA CCLE Cell Line Gene CNV Profiles 1.0 1.73019 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135350_2_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PWN1-0126-SM-2I3FK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827185 hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10229 induseum griseum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3582 GTEX-QMRM-1226-SM-447C6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09946 ETV3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2602 K562_ITSA-1_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152072 Perturb_1387_KO_IPO13_SRP128496 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.90152 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.829711 1040_C1ORF131_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.667935 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NRF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null extracellular organelle GO Cellular Component Annotations 2015 1.0 null PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3 Rummagene Transcription Factor Associations 2026 1.0 null CA46 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37712 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Roxadustat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154055 4147_INTS2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.549588 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.963 SPI1_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DOV13 CCLE Cell Line Gene CNV Profiles 1.0 2.14625 tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.165673 HCC70_BREAST CCLE Cell Line Proteomics 1.0 4.0647 Olfactory tubercle, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24747 GTEX-PLZ5-0726-SM-2I5F9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.902331 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42405 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSN1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.57781 TCF3-18347094-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null A549_LUNG CCLE Cell Line Proteomics 1.0 2.76193 RPMI8226 CCLE Cell Line Gene Expression Profiles 1.0 1.42314 GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33866 GATA3 ENCODE Transcription Factor Targets 1.0 null GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.54037 GTEX-QESD-1426-SM-2S1R9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938478 K562_SRT3025 HCl_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0220667 PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17996 Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F4-17652178-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26907 ELF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.31999 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRCA1 JASPAR Predicted Transcription Factor Targets 1.0 null PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_SL-327_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0127173 GSE252857_2_v_0_prednisone_mouse RummaGEO Drug Perturbation Signatures 1.0 null K562_BMS-265246_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0272437 Perturb_1388_KO_Tet1/3_ERP010627 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.9956 K562_SNS-314 Mesylate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0164094 2105_DDX18_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.620396 CP50-MEL-B Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.72214 tRNA-splicing ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.416 GSE112761,GSE112767_4_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null NH6 CCLE Cell Line Gene Expression Profiles -1.0 -1.83438 Perturb_1006_KO_Bcl9l/Bcl9_SRP045828 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.24581 RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.49354 Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.06952 POU3F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2032 AKAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06238 CAL51 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11739 GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 0.925495 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1688 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09797 GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.1949 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -2.31277 TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATP6AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15899 496100466_PCx_probable Alzheimer's disease_no TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.37221 superficial stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15536 GTEX-QV44-0826-SM-2S1RG GTEx Tissue Sample Gene Expression Profiles 1.0 0.972565 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_no_change_in_MLL-AF4_ChIP-seq_signal_28_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29954 2561_EIF4A3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.30504 19088021-supptable2 GeneSigDB Published Gene Signatures 1.0 null layer 3 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19585 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75065 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0933 K562_GSK1070916_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0227304 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 0.995328 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null external segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.872675 K562 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.969643 H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COV318 CCLE Cell Line Gene CNV Profiles 1.0 1.36057 GSE205730,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE149621_0_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null toxin-antitoxin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.304 r3 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15376 K562_Busulfan_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147536 PSKH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55992 GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2688 ChIP_MYCN_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MCF7_Sorafenib Tosylate_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0118115 POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Trametinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00977482 posteroventral (inferior) parietal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19087 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943615 GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles 1.0 0.843743 Motor nucleus of trigeminal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04579 P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 1.36535 RTL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91968 superficial stratum of r4BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73977 HOXA7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.1221 primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.50307 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.830775 pituitary GTEx Tissue Gene Expression Profiles 1.0 1.8822 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.886817 Perturb_5141_KO_Rn7sk_ERP002405 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.32739 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Ivosidenib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.018078 EHF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4613 GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14603 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -2.13971 CORL24 CCLE Cell Line Gene Expression Profiles 1.0 1.63217 H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.424 nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-94-7033-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IMR32 CCLE Cell Line Gene CNV Profiles -1.0 -2.27935 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1-22096565-GC-B-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CNN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08474 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 8228_SNRPD1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.580662 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16102 Perturb_10418_KD_Nuak1_ERP105467 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.03324 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.188 r10 part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0183 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6907-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09299 Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.51092 GTEX-WYVS-0006-SM-3NMA7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2493 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57244 A549_SRT3025 HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143036 GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59547 r10 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08921 NFIC ENCODE Transcription Factor Targets 1.0 null GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.39831 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU7-0001-SM-3NMAW GTEx Tissue Sample Gene Expression Profiles 1.0 2.00468 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11414 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-1426-SM-2S1OQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03503 A549_Alendronate sodium trihydrate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149995 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 1.835 PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null GSE220058,GSE220059_0_v_1_prrc2b_human RummaGEO Gene Perturbation Signatures 1.0 null ncrna metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-QEG4-0226-SM-2S1PY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89019 Perturb_17502_KO_Sod2_SRP328171 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.39217 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 431_AQR_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.517988 mammalian GeneRIF Biological Term Annotations 1.0 null Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.913963 Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PITX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6512 interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.22791 GTEX-NFK9-0726-SM-2HMJW GTEx Tissue Sample Gene Expression Profiles 1.0 0.895129 PMC9306206-12915_2022_1367_MOESM8_ESM.xlsx-Table_S9_-_JIP-Gene_SMAD4 Rummagene Transcription Factor Associations 2026 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDUFB8 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_17037_KD_RUNX2_SRP265978 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.52683 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-A5GW-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13591 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9459_KO_Srsf3_SRP143519 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.23655 7166_RBM25_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.534893 SP2 ENCODE Transcription Factor Targets 1.0 null GSE153836_14_v_1_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Fasudil_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155839 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Amygdala BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.03418 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.212936 GSE134029_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE104022_1_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RH00511 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.26 K562_Meprednisone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152102 GSE233679_6_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.429928 Acute Myeloid Leukemia_LAML_TCGA-AB-2803-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bed nuclei of the stria terminalis, anterior division, fusiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.17442 GATA4-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null G118 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.853949 FLI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE228727_2_v_0_dapagliflozin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120336_0_v_2_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null Pars reticulata TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.622 FOSL2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R55G-0226-SM-48FEI GTEx Tissue Sample Gene Expression Profiles 1.0 1.26212 FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F1 ENCODE Transcription Factor Targets 1.0 null Nucleus y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36054 superficial stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0281 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.254869 TAF2-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FOXA1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EC-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.222996 GSE114013,GSE114014_1_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null Olfactory tubercle, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17819 POLR2AphosphoS5_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-1626-SM-3LK5F GTEx Tissue Sample Gene Expression Profiles 1.0 1.00492 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSNK2A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23801 CBX2-22325352-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Fetal_Intestine_Large Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.917432 r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03408 Nonhomologous end joining complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.523 PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.968288 NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.952444 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MU-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9366_TSR2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.500292 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77125 GATA3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12405 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53373 intermediate part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57546 GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 0.89321 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.46325 Perturb_13826_OE_Pdgfra_SRP302970 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.51842 GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.50706 Liver Diseases CTD Gene-Disease Associations 1.0 1.17464 H3K4me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Orbital area, ventrolateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04286 GTEX-QLQW-0126-SM-447BK GTEx Tissue Sample Gene Expression Profiles 1.0 0.97839 ERVMER34-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67617 MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.40061 SIX5 ENCODE Transcription Factor Targets 1.0 null interstitial nucleus of the posterior limb of the anterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35734 GSE147056_3_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Aorta thoracica TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.968 DACH1-20351289-CHIP-SEQ-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null K562_AICAR_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0311738 GSE99687_3_v_1_smad5_human RummaGEO Gene Perturbation Signatures 1.0 null tRNA processing GO Biological Process Annotations 2025 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-6692-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.868445 ARID3A ENCODE Transcription Factor Targets 1.0 null placenta_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.24993 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 2102_DDX10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.625041 posteroventral (inferior) parietal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.62462 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05857 GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.967841 K562_Ellagic acid_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0269221 7458_RPL30_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.509703 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18396 GSE135030_3_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-O5YT-0526-SM-32PK8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58365 ATP6V1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02325 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Zic3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.6246 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Ki8751_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160252 BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.239306 K562_Dasatinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0211557 Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_3_GSC Rummagene Transcription Factor Associations 2026 1.0 null pallidal islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49695 MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Motesanib Diphosphate_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141073 Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE9857 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.54021 NH6 CCLE Cell Line Gene CNV Profiles -1.0 -1.62003 Perturb_5225_KO_Mettl3_SRP184527 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 16.1021 7461_RPL34_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.602688 H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4725_KO_Irx3_ERP116672 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 7830_SF3A1_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.501913 MCF7_A-366_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0196522 ZNF384 ENCODE Transcription Factor Targets 1.0 null SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C2BBE1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28187 locus ceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20969 GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 0.826431 Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null layer 3 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14019 K562_ITSA-1_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172574 7454_RPL27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.750469 MCF7_WP1066_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0215134 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.30771 GTEX-WK11-0006-SM-3NB3J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6183 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.838523 SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.70666 RPAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85319 cortico-medial group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10326 r2 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01023 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5UA-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Z-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JURKAT, CLONE E6-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE242290_1_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null pallidal part of olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68182 Lung adenocarcinoma_LUAD_TCGA-62-A46V-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3613-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5729_NOC2L_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.506237 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08911 Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_ZM 447439_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0241925 Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76002 indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.855247 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.58511 MAF-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.928687 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Fedratinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162162 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06482 GSE254649_2_v_1_cstf2_human RummaGEO Gene Perturbation Signatures 1.0 null NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null HSC4 CCLE Cell Line Gene Expression Profiles -1.0 -1.4726 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09803 GSE180377_2_v_1_lipa_mouse RummaGEO Gene Perturbation Signatures -1.0 null HNF4A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_SETDB1_19884255 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852977 MCF7_Bosutinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0124958 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.00103 GSE151612_0_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null ZBTB33_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171177,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-924 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 K562_WHI-P154_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0224993 TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18429 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26985 HSF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.2944 MBD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45479 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.84793 CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.843798 Intercalated amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71076 CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.972352 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE87412,GSE92423_0_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11165 Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MD-86-UW46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.26642 FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186810,GSE186813_2_v_1_furin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Axon collateral COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.627 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_XAV-939_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176535 K562_BMS-911543_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0194673 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.949105 Parasubiculum, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32135 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82088 MCF7_G007-LK_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139354 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Charcot-Marie-Tooth disease type 1D DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.289 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 HC-01-FD24_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.563632 GSE231799_3_v_4_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null Distal myopathy with anterior tibial onset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.292 USF1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J5-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.914836 GTEX-X8HC-2826-SM-46MWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10166 EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245439 BHLHE40_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGK2 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.83 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.05823 GA10 CCLE Cell Line Gene Expression Profiles 1.0 1.78949 HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LUC7L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03474 DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23727 GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11183 CORL24 CCLE Cell Line Gene CNV Profiles 1.0 2.59943 SCC25_UPPER_AERODIGESTIVE_TRACT CCLE Cell Line Proteomics 1.0 2.15837 Perturb_10319_KO_Pdk2_SRP216037 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Nucleomorph COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.159 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20189 spleen HPA Tissue Protein Expression Profiles 1.0 1.49892 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.948347 E2F4_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41223 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.915159 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.62538 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CJ-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null Nrf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 61.087 Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q4-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE190384,GSE190386_3_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null 10703_ZNRD1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.915264 K562_Baricitinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0343923 A549_Mercaptopurine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.021956 H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145215_0_v_3_krt13_mouse RummaGEO Gene Perturbation Signatures -1.0 null A549_UNC0379_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144407 NFYB-21822215-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null GSE60837_0_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-7173-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r3BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14892 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68413 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Ruxolitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015658 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3536 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8230_SNRPD3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.544521 CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.829048 HCC1195 CCLE Cell Line Gene CNV Profiles 1.0 1.95593 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07733 GSE125782_0_v_2_glutamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11068 CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFE2 ENCODE Transcription Factor Targets 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.954913 EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.637983 SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null superficial stratum of the IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35734 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23891 7507_RPS18_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.550698 BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7480_RPL8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.575723 Perturb_5228_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP194961 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 15.2648 MCF7_Resminostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0134736 CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217101_0_v_1_mcph1_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_Barasertib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177763 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.94923 trna-splicing ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 2.37797 MAFK ENCODE Transcription Factor Targets 1.0 null FRAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02104 GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.55978 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 NAMALWA Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.25624 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null amygdaloid complex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.955284 JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-1081-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-N-FI Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.25759 TYKNU CCLE Cell Line Gene Expression Profiles 1.0 1.49799 GTEX-Q734-0726-SM-48TZP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03709 EP300_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X8HC-0126-SM-4E3JW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898519 tonsil_8e1 HPA Tissue Sample Gene Expression Profiles 1.0 0.832985 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCRF-SB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.835439 IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.42628 lateral septal nucleus, intermedio-dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57334 r9 portion of vagal motor nucleus (postmigratory) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17189 LTBR_INHIBITION - 3 Day_GDS2004_735_mouse_Lymph nodes (MG-430A) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIRT6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null L363 CCLE Cell Line Gene Expression Profiles 1.0 1.50359 trans-Golgi network transport vesicle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.737 CHD1 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null GSE252857_2_v_3_prednisone_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_4943_OE_Hoxa13_SRP316002 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.83258 Mesolimbic dopaminergic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.549 MCF7_IOX2_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0178716 Perturb_10648_KD_AREG_SRP256639 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.14557 GATA2 ChEA Transcription Factor Targets 1.0 null Perturb_11818_KO_Nudt19_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.47437 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null GSE189683_1_v_0_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EB2 CCLE Cell Line Gene Expression Profiles 1.0 2.87187 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null MCF7_SB431542_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167677 Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03801 GTEX-WFJO-0002-SM-3P61X GTEx Tissue Sample Gene Expression Profiles 1.0 2.36058 USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2185 K562_PCI-34051_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149172 GSE112763,GSE112767_4_v_1_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.14437 Fine root TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.729 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_15_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04381 Colorectaladenocarcinoma BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.1215 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K23ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RCC4 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.992637 POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7466_RPL36_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.674042 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52509 GTEX-X3Y1-0726-SM-3P5YU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892952 Perturb_13222_KO_Hdac3_ERP123505 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -17.6326 PITX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.862 Tuberculosis DisGeNET Gene-Disease Associations 1.0 null GTEX-X5EB-0004-SM-46MWA GTEx Tissue Sample Gene Expression Profiles 1.0 1.57966 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R53T-0926-SM-3GADH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860087 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.901047 ENL-26711339-SEM-HUMAN-BLOOD-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KRT19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93332 K562_Avagacestat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0275516 VMRCRCZ CCLE Cell Line Gene CNV Profiles -1.0 -1.64307 PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC Rummagene Transcription Factor Associations 2026 1.0 null SETDB1-19884255-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null OXR1 Pathway Commons Protein-Protein Interactions 1.0 null PRPF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08536 EB1 CCLE Cell Line Gene Expression Profiles 1.0 2.40565 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.962245 K562_Momelotinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177413 CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100326_TCx_no dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.22265 Learning Disorders CTD Gene-Disease Associations 1.0 1.40595 A549_AICAR_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171858 Microglial cell_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19292 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15995 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null C11orf73 Pathway Commons Protein-Protein Interactions 1.0 null UACC257_SKIN CCLE Cell Line Proteomics 1.0 4.8102 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.879999 AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.519503 H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate GeneRIF Biological Term Annotations 1.0 null Perturb_4516_Mut_Ep400_SRP081300 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.96954 7441_RPL17_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.889221 HCC1569 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.651004 NCIH1838 CCLE Cell Line Gene Expression Profiles -1.0 -2.3299 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40566 H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_9517_Mut_Sall4_ERP111723 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.10148 DA-20-VR86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.454407 A549_Selisistat_10nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148847 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_1814_KO_N4bp1_SRP255180 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.17168 K562_Quercetin_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176006 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32585 inner CP in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4242 2932_RIPOR1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.590031 intermediate stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37445 Perturb_13202_KO_Hdac3_ERP123505 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.43268 nr2c2_20864514_liver_1yo_lof_mouse_gpl4134_gse21903 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.166423 primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.66586 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.928687 E2F6_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148658_1_v_0_six6_human RummaGEO Gene Perturbation Signatures -1.0 null Diagonal band TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.64 PMC11947124-41419_2025_7562_MOESM1_ESM.docx-119-ENSG00000198040_ZNF84 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.44252 GSE253795_1_v_0_alkbh5_human RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42413 7559_RRN3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.778268 HNF4A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Retrosplenial area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02136 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 0.889916 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null Perturb_13592_OE_Mir322/Mir503_SRP348669 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.55446 MCF7_PJ34_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167533 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 7449_RPL23A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.674825 Orbital area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00645 6118_PCED1A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.502703 YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null zinc acetate_homo sapiens_gpl570_gds1617 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 7451_RPL24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.744374 Perturb_5126_KD_Med30_SRP325525 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.81689 Perturb_5089_KO_Sall4/Sall1_ERP014607 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 6605_PPAN_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.634504 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.65546 CEBPB-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46177 HOXB4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2458 JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40521 GSE199255,GSE199356_4_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null A549_Entacapone_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161933 ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Azacitidine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0119059 Infralimbic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64232 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7449_RPL23A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.902599 A549_AG-14361_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0189743 PMC10350897-j_biol-2022-0528-S1.pdf-187-ZBTB43_ZBTB43 Rummagene Transcription Factor Associations 2026 1.0 null 7576_RSL1D1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.622455 YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.855849 K562_Linifanib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0221045 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48724 K562_MLN8054_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142747 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.61724 ATP5S Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles 1.0 2.45214 GTEX-SIU7-1126-SM-2XCDW GTEx Tissue Sample Gene Expression Profiles 1.0 0.95035 H2BK12ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-S7SF-0426-SM-3K2B7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58597 GOS3 CCLE Cell Line Gene CNV Profiles -1.0 -1.38946 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.883282 496100608_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.1052 SCAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2246 cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20965 transient Purkinje cell clusters Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.99668 ChIP_MYC_19079543 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4522_KO_Mapk3_SRP281895 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.5165 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.874321 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-1026-SM-4B64M GTEx Tissue Sample Gene Expression Profiles 1.0 1.29339 7455_RPL27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.606231 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1803 ALL-SIL Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.84051 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MAX_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS15 Pathway Commons Protein-Protein Interactions 1.0 null USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Serous gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.661 GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826889 KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215293 ovary_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.03888 NCIH2405 CCLE Cell Line Gene CNV Profiles -1.0 -1.34241 BRCA1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Resveratrol_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159222 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ACO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62867 PLXNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23041 PMC11947124-41419_2025_7562_MOESM1_ESM.docx-119-ZNF84_ZNF84 Rummagene Transcription Factor Associations 2026 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4683_KO_Mll2/Suz12_SRP189864 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.56531 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.899733 K562_Anacardic Acid_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0196039 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00507 RNF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDUFV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18935 posteroventral (inferior) parietal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06548 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Roxadustat_10nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163856 Acute Myeloid Leukemia_LAML_TCGA-AB-2985-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K79me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HMEL CCLE Cell Line Gene Expression Profiles -1.0 -3.99891 EP300_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1915 CCLE Cell Line Gene Expression Profiles 1.0 1.74793 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.64095 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null archaeal-type flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.856 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Disulfiram_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161015 inner CP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45972 7450_RPL23_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.643373 ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 3.05623 Perturb_5198_KO_Tsc2_SRP125196 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.00608 ZNF84 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36931 nb4 HPA Cell Line Gene Expression Profiles -1.0 -1.19662 H1F0 Pathway Commons Protein-Protein Interactions 1.0 null 7432_RPL10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.681565 PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1 Rummagene Transcription Factor Associations 2026 1.0 null stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50437 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null formation GeneRIF Biological Term Annotations 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.888842 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.83216 SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE70499_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null nucleic acid metabolic process GO Biological Process Annotations 2015 1.0 null HOXD13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6321 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-P4PQ-0326-SM-2HMJ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886943 NFIC_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5X1-0006-SM-3GIJZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893583 A549_Anacardic Acid_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0190064 E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Prednisone_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156158 K562_Capecitabine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.022323 SUZ12 ENCODE Transcription Factor Targets 1.0 null A549_Tanespimycin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0117553 cisplatin_mus musculus_gpl339_gse6206 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SPI1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Danusertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200554 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null periventricular stratum of r2Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30734 mantle zone of r1Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18923 USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-NPJ8-0011-R1a-SM-33HCB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0492 ABT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53983 Perturb_15850_KO_Etv5_SRP165224 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.02163 SKMEL28 CCLE Cell Line Gene CNV Profiles 1.0 1.43851 primary metabolic process GO Biological Process Annotations 2015 1.0 null CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HAND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11218 STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34486 A549_Zileuton_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141058 Perturb_9411_KD_Pcbp1_SRP251371 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.73959 periventricular stratum of r10Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19134 BE-74-SX40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.327234 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28908 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Parastrial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11492 D-566MG COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_4987_KO_Mettl3_SRP212677 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.6729 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.831542 ILK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32216 H3K23ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Microsporidian TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.965 r9 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61201 r4 part of medial paralemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3972 NCIH810 CCLE Cell Line Gene Expression Profiles 1.0 1.81392 K562_ENMD-2076 L-Tartaric acid_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159525 SUDHL5 CCLE Cell Line Gene Expression Profiles 1.0 1.81591 MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.200045 RABGGTB Pathway Commons Protein-Protein Interactions 1.0 null artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.523982 A549_SL-327_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177789 GTEX-P4PP-1026-SM-3NM9O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960004 Perturb_11836_KO_Selenbp1_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.68556 MCF7_Celecoxib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.019881 GTEX-UPK5-0426-SM-3GAEK GTEx Tissue Sample Gene Expression Profiles 1.0 1.10827 TRMU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04156 GSE202434,GSE202438_6_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null LCLC97TM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.45668 GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.49996 EEF1B2 Pathway Commons Protein-Protein Interactions 1.0 null NTS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70428 anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.01531 Brain_Germinal_Matrix Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -2.28483 8738_TBL3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.563024 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.10391 SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null polymorph layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71925 roof plate of p2 (epithalamic roofplate) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.40921 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I1-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FD-29-MM50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.375916 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_2_GSC Rummagene Transcription Factor Associations 2026 1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-A5C4-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IGROV1_OVARY CCLE Cell Line Proteomics 1.0 3.92164 MRPL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56026 medial pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1465 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Large latent transforming growth factor-beta complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.556 pancreas HPA Tissue Gene Expression Profiles -1.0 -1.16658 CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.25261 BCLAF1 ENCODE Transcription Factor Targets 1.0 null GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18274 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15995 GFI1B-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null subthalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09877 organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-VJYA-0926-SM-4KL1N GTEx Tissue Sample Gene Expression Profiles 1.0 0.827294 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Vandetanib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140453 Primary Myelofibrosis DisGeNET Gene-Disease Associations 1.0 null 9587_UMPS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.516845 MCF7_Flavopiridol HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00880309 7476_RPL6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.709713 MYO18A Pathway Commons Protein-Protein Interactions 1.0 null GSE81803,GSE81912_0_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null LAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13643 Nerve cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.105 ZNF766 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.275 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE168602,GSE168604_2_v_6_selumetinib_human RummaGEO Drug Perturbation Signatures -1.0 null K562_SRT1720 HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0303363 GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989882 GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28818 GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32828 GSE143743_0_v_2_c9orf72_human RummaGEO Gene Perturbation Signatures 1.0 null PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF Rummagene Transcription Factor Associations 2026 1.0 null MCF7_PF-573228_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151543 K562_Iniparib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0182404 SA1-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.176 3586_GTF3C3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.63903 superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71925 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.880665 TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCFL_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-371b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 mediodorsal nucleus of thalamus_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.43608 DOHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03149 intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13092 PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null tRNA processing GO Biological Process Annotations 2023 1.0 null NE-94-VE83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283048 CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-T5JC-2526-SM-4DM6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.05489 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE225218_0_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41317 hsa-miR-4755-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0149 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HD-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DV90 CCLE Cell Line Gene CNV Profiles -1.0 -1.81909 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25145 anterodorsal nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36763 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MIAPACA2_PANCREAS CCLE Cell Line Proteomics 1.0 2.15312 GSE215155_0_v_1_golph3_human RummaGEO Gene Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08701 GTEX-U3ZM-0426-SM-3DB73 GTEx Tissue Sample Gene Expression Profiles 1.0 0.970171 GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles 1.0 0.8269 Root cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.614 PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-220-ZBTB24_ZBTB24 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.57924 HOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7156 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE157594_0_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null CDC27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36763 874_BOP1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.635121 LIN7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7936 KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle GO Cellular Component Annotations 2015 1.0 null GSE165122_2_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Avagacestat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.015019 5762_NPAT_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.749076 lateral preoptic area, PO1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25572 RNA splicing, via endonucleolytic cleavage and ligation GO Biological Process Annotations 2025 1.0 null GSE151090_5_v_1_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.827109 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26084 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MKN45_STOMACH CCLE Cell Line Proteomics 1.0 3.08611 MEG-01 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.6692 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.931089 CDX2-21074721-CACO-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null K562_JNJ-26854165_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167798 GSE228413_2_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 EST1-17652178-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.96349 POT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.328 SREBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41095 CTCFL_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6874_PSMD6_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.0632 Perturb_7522_KD_MALAT1_SRP225193 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.30167 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null bewo HPA Cell Line Gene Expression Profiles -1.0 -1.13683 A549_Roxadustat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161397 NANOG ChEA Transcription Factor Targets 1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERBB2_druginhibition_7_GDS2139 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.8682 CORL88 CCLE Cell Line Gene CNV Profiles 1.0 1.98823 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HF-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6534_POLR1B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.569841 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.964306 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_M344_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0126747 primary auditory cortex (core)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00765 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.60916 GATA2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null OACP4C COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 KIAA1279 Pathway Commons Protein-Protein Interactions 1.0 null retina BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.07554 hsa-miR-4277 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 MCF7_Fluorouracil_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143808 H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null membrane-bounded vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_13198_KO_Dax1_ERP123502 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.44185 H2AK5ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-A46O-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YV-0006-SM-2I5GX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32485 GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.82159 GTEX-PX3G-0926-SM-48U12 GTEx Tissue Sample Gene Expression Profiles 1.0 0.853044 MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20375 Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Celecoxib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184952 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 1.1636 NR2F2 ENCODE Transcription Factor Targets 1.0 null OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22175 K562_Pirarubicin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180805 MCF7_Fedratinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179891 6533_POLR1A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.521457 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32413 UT7 CCLE Cell Line Gene Expression Profiles -1.0 -1.4698 Perturb_15851_KO_RbpJ_SRP165224 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GABPA_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81974 CHD7 ENCODE Transcription Factor Targets 1.0 null e2f1_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.153163 TMD8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.85635 K562_Enzastaurin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179494 intermediate stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59431 GTEX-T6MN-0126-SM-32PLP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02582 mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7656 protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 7492_RPP38_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.542772 r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30725 GATA2_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A53L-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null cisplatin_homo sapiens_gpl570_gds3910 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XLM4-0011-R9A-SM-4AT45 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989225 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834801 POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null 8229_SNRPD2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.516677 cellular aromatic compound metabolic process GO Biological Process Annotations 2015 1.0 null POU6F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6394 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.76571 STAT1-17558387-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.845547 CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Valproic acid sodium salt_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0131482 TBL1-22424771-293T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_20_OE_Smarca5_SRP217699 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.5152 2129_DDX54_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.565608 Perturb_1873_KO_Ifnar_SRP371304 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.7931 GSE111247_14_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_77_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.18854 GSE216043_10_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Fetal Death CTD Gene-Disease Associations 1.0 1.11809 intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_KW-2449_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0191882 GTEX-P4QS-2026-SM-3NMCG GTEx Tissue Sample Gene Expression Profiles 1.0 1.02955 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EVX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.1522 H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17238 GTEX-T8EM-0006-SM-3DB71 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40991 Perturb_3854_KO_ITPR3_SRP332879 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.38326 K562_CYC116_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0250025 K562_Avagacestat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0192841 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.99574 Perturb_13271_KO_Msl2_SRP192624 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.77607 SMC3 ENCODE Transcription Factor Targets 1.0 null GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles 1.0 2.38316 SP2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12673788-12967_2025_7484_MOESM5_ESM.xlsx-OCT4_cor_p_0_4-gene_id_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null MYCN ChEA Transcription Factor Targets 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950001 PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null Perturb_4767_KO_Kap1_SRP065215 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.75315 Morula cell (Blastomere)_Embryo_Human CellMarker Gene-Cell Type Associations 1.0 null PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF Rummagene Transcription Factor Associations 2026 1.0 null UTX-26944678-CHIP-SEQ-JUKART-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 6793_PRPF31_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.654959 9686_UTP3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.970721 815_BDP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.502299 HEL9217 CCLE Cell Line Gene CNV Profiles 1.0 1.51961 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38467 ELF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.72974 VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17538 EGR1 ENCODE Transcription Factor Targets 1.0 null posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.43044 PHF8 ENCODE Transcription Factor Targets 1.0 null REC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 3.86474 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100403_TCx_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16911 anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.887084 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.21402 GSE202434,GSE202438_15_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null PTPN14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31241 SNU1196 CCLE Cell Line Gene CNV Profiles 1.0 1.83338 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.53587 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -2.0826 SNU201 CCLE Cell Line Gene Expression Profiles -1.0 -1.78236 ETV5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2152 TAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57775 ASPC1_PANCREAS CCLE Cell Line Proteomics 1.0 2.21366 KO52 CCLE Cell Line Gene CNV Profiles 1.0 1.47749 GSE70499_5_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-POYW-0826-SM-2XCEM GTEx Tissue Sample Gene Expression Profiles 1.0 0.947024 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4Q7-0003-SM-3NM8M GTEx Tissue Sample Gene Expression Profiles 1.0 1.44863 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM4E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18183 THAP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-2026-SM-4BOOW GTEx Tissue Sample Gene Expression Profiles 1.0 1.2893 Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 8517_STK24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.640617 MCF7_Roscovitine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0112805 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.35503 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71491 GTEX-R53T-0005-SM-3GADK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02524 K562_Lenalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.039187 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12817 GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rtcbguanylate GeneRIF Biological Term Annotations 1.0 null GTEX-S7PM-0126-SM-4AD6S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03935 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.84751 RTBDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21397 SNU5 CCLE Cell Line Gene CNV Profiles -1.0 -1.9488 ILF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16933 cell part GO Cellular Component Annotations 2015 1.0 null CL14 CCLE Cell Line Gene Expression Profiles -1.0 -1.48701 PcPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06201 GSE205163,GSE205164_3_v_6_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TML8-1326-SM-4DXTO GTEx Tissue Sample Gene Expression Profiles 1.0 1.06743 MAX ENCODE Transcription Factor Targets 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null medial group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.876573 GSE160373_5_v_4_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10512 OB-06-WW76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346084 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCPAP CCLE Cell Line Gene CNV Profiles 1.0 1.55652 GTEX-TKQ1-0003-SM-3NMAE GTEx Tissue Sample Gene Expression Profiles 1.0 2.6117 colonrectum_f HPA Tissue Sample Gene Expression Profiles 1.0 0.824075 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE95077_1_v_0_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null MBD4 ENCODE Transcription Factor Targets 1.0 null A549_BMS-754807_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0171884 inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.938743 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.02587 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.912109 Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2834-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_PFI-1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.023342 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63332 MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.07551 PANC0213 CCLE Cell Line Gene CNV Profiles -1.0 -1.34016 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KD-31-TU05_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217631 7463_RPL35_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.639311 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.141 KLF4 ChEA Transcription Factor Targets 1.0 null NCI-H2023 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.92107 TK-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.904379 GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00818 MCF7_Resveratrol_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0186082 reticular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02876 HCC1569 CCLE Cell Line Gene Expression Profiles 1.0 1.39242 K562_Iniparib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184037 GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24256 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054922 K562_Thalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0215547 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null retromammillary area, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61284 A549_FLLL32_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0138646 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827014 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.926916 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Raltitrexed_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0212316 GTEX-WWYW-1326-SM-3NB2S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860772 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.55761 TFCP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0108 Rfx6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.7091 MCF7_Avagacestat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139099 SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null vitamin c_homo sapiens_gpl570_gds3635 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE159967_3_v_0_arid5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null COACH syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE95685_6_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null K562_Mesna_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016477 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE228181_3_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_Navitoclax_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180712 ZR751 CCLE Cell Line Gene CNV Profiles -1.0 -1.34963 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RA-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Carmofur_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0115511 Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07039 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE247862,GSE247863_0_v_5_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles 1.0 2.93675 GSE102505_4_v_2_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE189683_3_v_0_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EHEB CCLE Cell Line Gene Expression Profiles 1.0 1.50114 ZBTB33_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6074 Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40695 GSE235516_0_v_1_zdhhc2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U4B1-1026-SM-4DXT1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1877 Perturb_9516_Mut_Sall4_ERP111723 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.95277 SIN3A ENCODE Transcription Factor Targets 1.0 null TPCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30382 GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55258 GSE205556_2_v_0_bexarotene_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null APOE Pathway Commons Protein-Protein Interactions 1.0 null POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7453_RPL26_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.664908 HOXB4 ChEA Transcription Factor Targets 1.0 null SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_AG-14361_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0262195 496100420_PCx_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.61922 GTEX-RUSQ-0226-SM-47JWT GTEx Tissue Sample Gene Expression Profiles 1.0 1.13692 r8 part of the paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08493 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ATF2 ENCODE Transcription Factor Targets 1.0 null PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null SETDB1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.25124 Adrenocortical carcinoma_ACC_TCGA-OR-A5JB-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles 1.0 1.83535 GTEX-WZTO-0426-SM-3NM99 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867424 PMC12673788-12967_2025_7484_MOESM5_ESM.xlsx-Venne_panel-Only_OCT4_related_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.7522 6071_PARK7_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.605896 UBTF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02325 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null K562_JQ1_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152904 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-0726-SM-3GIJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01219 FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.277396 GSE213048_1_v_2_irf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.85475 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null 7504_RPS15_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.572436 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GFI1B-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042452 MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Radial spoke COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.621 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120336_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null K562_TAK-901_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0136015 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05258 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13184 K562_S3I-201_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158323 Septal area TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.511 dorsolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04505 PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1 Rummagene Transcription Factor Associations 2026 1.0 null MZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47871 superficial stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29718 ELK1 ChEA Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Linifanib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0190725 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 1.99428 PFEIFFER CCLE Cell Line Gene Expression Profiles 1.0 1.50686 MTIF3 Pathway Commons Protein-Protein Interactions 1.0 null dorsal juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.227 1083_NEPRO_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.96972 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.82248 hsa-miR-211 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 E2F1 JASPAR Predicted Transcription Factor Targets 1.0 null cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.9481 Angioblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.767 Lung BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.41399 K562_Ki8751_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0246424 GTEX-QV44-0926-SM-2S1RH GTEx Tissue Sample Gene Expression Profiles 1.0 1.29992 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12416 Charcot-Marie-Tooth disease type 1C DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.01 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13197 Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YT-0926-SM-48TDG GTEx Tissue Sample Gene Expression Profiles 1.0 1.09661 Bed nucleus of the anterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0753 SETDB1-19884255-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null GSE190384,GSE190386_2_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null GATA6-21074721-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null orbital frontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.938783 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16976 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.44818 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.72449 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95836 medial mammillary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.93025 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MET_knockout_258_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -0.827212 2291_DNAJC17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.823324 H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLU Pathway Commons Protein-Protein Interactions 1.0 null r6 part of nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08598 superficial stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43146 GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles 1.0 2.37412 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4294 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Perturb_13377_KO_Sox10_SRP267687 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.55744 CHP126 CCLE Cell Line Gene CNV Profiles -1.0 -2.14105 GSE233679_5_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Ki16425_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177874 striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.44905 hsa-miR-513a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GTEX-R55C-0526-SM-3GIKA GTEx Tissue Sample Gene Expression Profiles 1.0 0.831296 FOXP2 ENCODE Transcription Factor Targets 1.0 null 2120_DDX41_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.538386 GSE196104,GSE196106_2_v_1_vsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S4UY-0006-SM-3K2A7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856558 GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles 1.0 2.20407 ND-54-NO97_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203982 GSE151782_4_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.33742 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.01834 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CE-23-HP88_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.727099 hsa-miR-3125 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 K562_PD98059_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209365 Perturb_654_KD_lncRNA_104449_SRP093784 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.37618 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE152432_6_v_0_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_PFI-1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0235541 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47588 GTEX-PLZ5-0826-SM-3P5ZW GTEx Tissue Sample Gene Expression Profiles 1.0 0.829754 CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.91158 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05285 medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.23184 GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 0.934891 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.833697 methotrexate_homo sapiens_gpl570_gse11440 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01217 GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.11867 NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DD-74-PJ26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.268054 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45479 Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bmi1_Deficiency_GDS4816_323_mouse_Primary lung cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14709 Lung squamous cell carcinoma_LUSC_TCGA-34-2600-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prdm15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.2517 M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.52515 Plantlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.798 MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Enzastaurin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0131503 REST_Panc1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null tonsil HPA Tissue Gene Expression Profiles 1.0 1.41301 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null X-linked parkinsonism-spasticity syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.843 CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_766_mouse_Skin - 0 Day GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31883 Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Temsirolimus_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016478 Perturb_661_KD_lncRNA_177417_SRP093784 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.33459 FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.51965 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.918102 eGFP-NR4A1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-0726-SM-3NMBM GTEx Tissue Sample Gene Expression Profiles 1.0 0.946178 GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41428 Pirenzepine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.47 H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null archease GeneRIF Biological Term Annotations 1.0 null H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.09516 GTEX-WYBS-0626-SM-3NMAS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94961 496100397_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21133 PF 04447943 DeepCoverMOA Drug Mechanisms of Action 1.0 0.26 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inner CP in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66019 GTEX-QV31-0726-SM-3GAEG GTEx Tissue Sample Gene Expression Profiles 1.0 0.827701 K562_BRD4770_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172396 Anterior olfactory nucleus, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85514 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.70777 Perturb_11805_KO_Gpsm1_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.40285 Ventral nerve cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.057 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.0189 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OB-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140651,GSE140653_5_v_7_med1_human RummaGEO Gene Perturbation Signatures -1.0 null EKC/KEOPS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.656 A549_Bisindolylmaleimide IX_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0132523 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14176 ELF1 ENCODE Transcription Factor Targets 1.0 null K562_RG108_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0266622 GTEX-XMD1-0011-R9A-SM-4AT49 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18018 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17238 Metabolism of RNA Reactome Pathways 2024 1.0 null GTEX-SN8G-0001-SM-3NM8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.52491 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.30162 brownfat BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.906179 SIN3A_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tadpole TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.739 Perturb_11839_KO_Slc7a13_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.19024 7463_RPL35_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.601625 HNF4A ENCODE Transcription Factor Targets 1.0 null MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.848913 Perturb_1866_KO_Ifnar_SRP371304 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GSE111247_11_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31883 K562_AMG-900_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0281946 6963_PWP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.511645 K562_SB431542_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0337294 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4680_KO_Psip1_SRP153901 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.03111 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles 1.0 2.26576 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.92303 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.966586 K562_Veliparib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0214266 7455_RPL27_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.725227 mammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21504 K562_Cediranib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0243626 layer 3 of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08942 GSE184892_6_v_1_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null KPNYN CCLE Cell Line Gene CNV Profiles -1.0 -1.7909 Perturb_15236_KO_Scl/Tal1/Lyl1_SRP179031 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.74689 MYBL2 ENCODE Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE137144_5_v_6_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE189772,GSE189773_3_v_2_fbxo11_human RummaGEO Gene Perturbation Signatures 1.0 null PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE63048_11_v_8_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null r1 part of trigeminal sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18766 POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null unknown GeneRIF Biological Term Annotations 1.0 null GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00945 ChIP_KLF4_19030024 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GADD45GIP1 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.269568 639-V Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.75888 NR4A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1467 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.838679 MCF7_Droxinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016195 GATA1_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null A549_Cediranib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163532 KURAMOCHI CCLE Cell Line Gene CNV Profiles 1.0 1.40676 MCF7_SL-327_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0102911 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYA-21822215-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null DF-95-CY55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.637684 striatum_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.846144 GSE186280_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GB-84-KP45_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.224081 cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null MBD4_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE62974_1_v_0_epas1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.09617 H3K18ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 2132_DDX56_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.904733 K562_SGI-1776 free base_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162459 extracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null SPI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16346 GSE111035,GSE111040_3_v_12_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null inferior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.86434 GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.989001 REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-52-7812-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BV173 CCLE Cell Line Gene Expression Profiles -1.0 -1.89317 Presubiculum, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10589 MCF7_PD98059_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157206 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-90-EX35_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214028 K562_Costunolide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0231725 PMC5031867-mmc2.xlsx-RYTTCCTG_V_ETS2_B-PROBE_ETS2 Rummagene Transcription Factor Associations 2026 1.0 null GSE160001,GSE160670_0_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures -1.0 null REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null STK368746 DeepCoverMOA Drug Mechanisms of Action 1.0 0.3 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852488 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.84643 HA-E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22713 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_NVP-BSK805 2HCl_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148251 GTEX-XMD1-0011-R1A-SM-4AT4C GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844232 RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_AMG-900_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.011818 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 0.949387 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05285 GTEX-WI4N-1026-SM-3LK7N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06941 MANF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39266 4126_INO80B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.61737 cingulate gyrus, parietal part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.985396 POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Tranylcypromine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015841 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Orbital area, ventrolateral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14329 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null superficial stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94433 Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_BMS-911543_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158977 EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.862814 anterior digastric muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03458 nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.358653 GTEX-S4Z8-0426-SM-3K2AH GTEx Tissue Sample Gene Expression Profiles 1.0 1.30465 GTEX-P78B-0926-SM-2I5FA GTEx Tissue Sample Gene Expression Profiles 1.0 1.19669 GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 0.881821 CDK19_knockdown_164_GSE38061 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.44186 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE144231_3_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-2426-SM-3MJHL GTEx Tissue Sample Gene Expression Profiles 1.0 0.973919 intermediate stratum of r1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2665 GTEX-X8HC-0626-SM-4E3HQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12137 CTR9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90349 GTEX-XUJ4-0226-SM-4BOP8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.962353 Perturb_17510_KD_Klf4_SRP338421 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.75107 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.953251 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946329 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57316 1458_CDT1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.502925 extracellular vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 2580_EIF6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.581953 NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09361 GSE183335,GSE183351_1_v_2_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null MTRR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1593 TEAD4_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148200_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null r8 part of linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13015 primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42685 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 1.57217 Perturb_600_KO_Runx1_SRP267560 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.4228 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.982806 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.42218 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Azacitidine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0211362 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L6-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151090_5_v_3_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB33_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EVX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2772 GTEX-V1D1-0003-SM-3NMDP GTEx Tissue Sample Gene Expression Profiles 1.0 1.90959 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.289675 Lung adenocarcinoma_LUAD_TCGA-64-5781-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PANC0213 CCLE Cell Line Gene Expression Profiles -1.0 -1.67624 GTEX-Q2AI-0526-SM-2I3EJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.1969 Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Barasertib_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.01235 H2AK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_11824_KO_Popdc3_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.65827 GSE202603_1_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures -1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.840648 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01696 Supramammillary nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50567 u26684 HPA Cell Line Gene Expression Profiles 1.0 1.01942 intermediate stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13628 UBF1/2-26484160-CHIP-SEQ-HMEC-DERIVED-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE227592_8_v_3_adar_human RummaGEO Gene Perturbation Signatures 1.0 null HNF4G ENCODE Transcription Factor Targets 1.0 null POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-1626-SM-4E3IV GTEx Tissue Sample Gene Expression Profiles 1.0 1.15614 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PADI4-21655091-MCF7-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-SNOS-1226-SM-4DM5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.12597 Parabrachial nucleus, medial division, external medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17086 ETV6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7161 lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.880029 K562_Gandotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171631 4154_INTS9_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.524625 A549_INO-1001_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165957 GTEX-S4UY-0126-SM-3K2BB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934188 Perturb_2733_KD_BCKDK_SRP298085 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.73614 Hemoglobin H disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.107 trna metabolic process GO Biological Process Annotations 2015 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE246053_1_v_2_hnf4a_mouse RummaGEO Gene Perturbation Signatures -1.0 null NE-94-VE83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206239 POLR2AphosphoS5_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rna metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965256 vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.344449 PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null GABP-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_13644_KD_Trim28_SRP126388 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.62551 GSE215351,GSE215794_1_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.62212 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050333 K562_Ramelteon_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0215675 K562_Altretamine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0198634 GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86723 cation binding GO Molecular Function Annotations 2015 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.24281 E2F4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7453_RPL26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.790758 ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NCO2 CCLE Cell Line Gene Expression Profiles -1.0 -1.75098 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KLF4-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE186440,GSE186443_0_v_5_daxx_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles 1.0 1.72247 anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.05139 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE111035,GSE111040_10_v_9_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ovary_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.72957 Perturb_5124_KD_Med28_SRP325525 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.65175 K562_Resminostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0200354 GABP-17652178-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE149901_2_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.977865 GSE148066,GSE157787_2_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 3.64909 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 1.3766 CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.6453 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.41306 A549_Iniparib_100nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0188754 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null K562_AG-14361_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164579 periventricular stratum of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08598 r7 part of the nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24025 RET_druginhibition_184_GSE49414 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.65548 GTEX-X15G-0526-SM-3NMB7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.870135 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04307 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5470-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34477 GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.31261 POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE172146_2_v_0_mettl1_human RummaGEO Gene Perturbation Signatures 1.0 null USF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE95685_2_v_5_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16901 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Scutellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.544 EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.81032 Xeroderma Pigmentosum DisGeNET Gene-Disease Associations 1.0 null Medial longitudinal fasciculus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.636 nucleus GO Cellular Component Annotations 2025 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_INO-1001_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0301299 K562_ENMD-2076_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0133005 HOXC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8535 CBFbeta_Deficiency_GDS3577_557_mouse_Regulatory T cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.906103 Flocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62444 GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tRNA-intron endonuclease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.865 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QV31-0126-SM-447BP GTEx Tissue Sample Gene Expression Profiles 1.0 1.1875 NR4A2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4466 A549_Resveratrol_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0226121 central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58232 u266 HPA Cell Line Gene Expression Profiles 1.0 1.2119 artery wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.525955 LTBR_INHIBITION - 35 Day_GDS2004_737_mouse_Lymph nodes (MG-430A) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MCF7_Ellagic acid_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.017343 EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.95346 MCF7_Nintedanib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0108358 NANOG ENCODE Transcription Factor Targets 1.0 null Acenaphthoquinone DeepCoverMOA Drug Mechanisms of Action -1.0 -0.27 ligation GeneRIF Biological Term Annotations 1.0 null 6845_PSMA5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.660466 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055955 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intercalated amygdaloid nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.08415 facilitates GeneRIF Biological Term Annotations 1.0 null GSE139966_4_v_3_figla_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61824 PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921285 Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_665_KO_Myc_SRP093784 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.25026 TCF7L2 ENCODE Transcription Factor Targets 1.0 null extracellular region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Duodenum Mucosa Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.0876 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null H2BC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30744 NANOG-16153702-HESC-human ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cisplatin_mus musculus_gpl339_gds3099 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SIN3A_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.278641 YY1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null macromolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ELF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2198 K562_AG-14361_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0397145 K562_Momelotinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0237241 K562_ZM 447439_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209119 ELK1-22589737-MCF10A-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE125014_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null A549_CYC116_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177675 trna splicing, via endonucleolytic cleavage and ligation GO Biological Process Annotations 2015 1.0 null MCF7_Givinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00941527 HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48415 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.31399 GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 0.894306 FOSL1 ENCODE Transcription Factor Targets 1.0 null ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF1 ENCODE Transcription Factor Targets 1.0 null GATA3-24758297-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MCF7_Altretamine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144153 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX2-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040155 SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-0226-SM-2I5FV GTEx Tissue Sample Gene Expression Profiles 1.0 1.14433 Lung squamous cell carcinoma_LUSC_TCGA-22-5481-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventromedial hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03998 SLR24 CCLE Cell Line Gene CNV Profiles -1.0 -1.46991 GSE151090_5_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null pontine nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25294 RPS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14787 ZBTB33_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCOR1-26117541-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04148 MCF7_GSK1070916_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0121225 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC11143964-jciinsight-9-161356-s009.pdf-46-ZNF646_ZNF646 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23841 5738_NOL9_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.553536 PMC12706077-44318_2025_598_MOESM21_ESM.xlsx-Dataset_EV19-hKidney_TPP-PISA-Genes_ZNF568 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null inner CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.943201 Perturb_10364_KD_Setd2_SRP184682 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.00033 molecular_function GO Molecular Function Annotations 2015 1.0 null GTEX-T5JW-1426-SM-4DM5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.96529 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21785 PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1293 K562_G007-LK_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0226479 WEE1_druginhibition_307_GSE38972 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.84836 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4528_KD_Chaf1a_SRP060878 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.08849 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HA-27-FV67_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.317054 mantle zone of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21666 GSE191105_2_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.10778 MYC-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7438_RPL14_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.504079 GTEX-RWSA-1426-SM-47JXA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896827 H3K79me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHEMBL1436068 DeepCoverMOA Drug Mechanisms of Action 1.0 0.26 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22053 TE441T CCLE Cell Line Gene CNV Profiles -1.0 -3.11262 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46271 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.237647 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7839_SF3B5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.546933 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_15644_KD_Cebpb_SRP160879 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.86705 GTEX-OHPM-0126-SM-2YUN9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.937832 inner CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1357 Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRABD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52204 SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.44059 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null required GeneRIF Biological Term Annotations 1.0 null Perturb_9236_KO_Kmt2d_SRP152944 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.51506 spleen GTEx Tissue Gene Expression Profiles 1.0 0.941811 5964_LTO1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.655891 A549_GSK J1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140607 GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles 1.0 2.15095 protein complex GO Cellular Component Annotations 2015 1.0 null primary auditory cortex (core)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.869202 CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null MCF7_ENMD-2076 L-Tartaric acid_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0215252 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YE-46-YA12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.370592 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sec61 translocon complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.237 MCF7_AG-14361_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0195296 branchial arch TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.925907 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227592_6_v_3_adar_human RummaGEO Gene Perturbation Signatures 1.0 null MEX3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29703 GSE125007,GSE125008_10_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-320c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE202434,GSE202438_9_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_S3I-201_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0210398 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11544 K562_Busulfan_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146365 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48243 Myoclonic dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.197 NCIH2081 CCLE Cell Line Gene Expression Profiles 1.0 1.40883 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7166-01A-12R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.369226 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.87221 bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.876952 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.901047 testosterone_mus musculus_gpl1261_gse17553 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LD-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 9909_XRCC6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.729538 eosinophilia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.847488 PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_12Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.40672 NANOG_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null r10 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21612 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00602 CREB1 JASPAR Predicted Transcription Factor Targets 1.0 null 4684_LSG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.589486 GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.69604 temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16952 NCOR1 ENCODE Transcription Factor Targets 1.0 null K562_Alendronate sodium trihydrate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.023339 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Sodium Phenylbutyrate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0205362 Perturb_4814_KO_Neil1_SRP193096 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.82644 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Central amygdalar nucleus, capsular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31384 A549_Tazemetostat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.017544 Bergenin DeepCoverMOA Drug Mechanisms of Action 1.0 0.43 GSE202434,GSE202438_13_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08627 MET_knockout_264_GSE8747 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.53838 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.27591 Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.44954 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.949105 H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.868445 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14784 GTEX-R3RS-0726-SM-3GIJR GTEx Tissue Sample Gene Expression Profiles 1.0 0.859456 K562_Toremifene Citrate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0220357 GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851828 K562_Enzastaurin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0276831 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04919 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA-42-YI34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.24566 Lung adenocarcinoma_LUAD_TCGA-91-8496-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_BMS-754807_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0214196 intermediate stratum of r1Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23141 K562_Clevudine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162985 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ddx1 GeneRIF Biological Term Annotations 1.0 null Rad17 RFC-like complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.954 Olfactory tubercle, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3937 SUDHL6 CCLE Cell Line Gene Expression Profiles 1.0 1.8829 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null 7569_RRS1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.534368 IRF3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47576 KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.29586 SP1 ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2981-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null K562_Alisertib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0212801 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE202434,GSE202438_10_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16081 GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.41375 SubthalamicNucleus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.863589 H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MCF7_Tucidinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0136798 GSE226584,GSE226589_3_v_0_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null 17023574-TableS1 GeneSigDB Published Gene Signatures 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null GSE135030_3_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null PB-18-HD85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229516 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25271 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.77011 7445_RPL21_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.522627 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.206258 Infralimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26391 H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4709_KO_Hesx1_ERP023509 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.75993 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.72986 GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866525 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_INO-1001_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150153 Lung squamous cell carcinoma_LUSC_TCGA-58-8387-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRIM61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00039 EP300_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null germ layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065021 OB-06-WW76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.226628 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null GSE115395_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE215351,GSE215794_1_v_0_kdm8_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH1838 CCLE Cell Line Gene CNV Profiles -1.0 -2.14615 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -4.02287 CEBPD_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPP2R5E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3618 CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.74915 K562_Pirarubicin_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0135378 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02589 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null external part of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.08643 GSE191105_2_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13194_KO_Dax1_ERP127280 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.99453 E2F4-17652178-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null IMR32 CCLE Cell Line Gene Expression Profiles -1.0 -1.88977 CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.978279 central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1474 ZC3H11A ENCODE Transcription Factor Targets 1.0 null SDHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45161 HCC1187 CCLE Cell Line Gene CNV Profiles 1.0 1.43516 SPDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62491 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.82763 GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles 1.0 1.51013 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.938413 GTEX-RU72-3126-SM-46MUB GTEx Tissue Sample Gene Expression Profiles 1.0 1.01979 GTEX-OXRO-0011-R10A-SM-2I5EH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846416 PU.1-20513432-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null a549 HPA Cell Line Gene Expression Profiles -1.0 -1.03578 dorsal subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64772 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-587 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 7443_RPL18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.559136 primary auditory cortex (core)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13073 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00741 r2 part of vestibular nucleus Y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30791 hsa-miR-320b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 STAT3-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PLEKHO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30472 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.23625 hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10252 GTEX-OXRK-0226-SM-3NB2G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965602 GSE125007,GSE125008_6_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 2132_DDX56_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.594247 ZNF76 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.9231 hsa-miR-320d TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Dapiprazole DeepCoverMOA Drug Mechanisms of Action 1.0 0.47 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null lateral part of MM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50714 ACCMESO1 CCLE Cell Line Gene Expression Profiles 1.0 1.43378 JUN ENCODE Transcription Factor Targets 1.0 null VMRCLCP CCLE Cell Line Gene CNV Profiles -1.0 -1.36171 Striatum-like amygdalar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0204 GSE221020,GSE221023_2_v_1_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_664_KD_lncRNA_Pvt1_SRP093784 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.23312 GSE242290_3_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null Ibutilide DeepCoverMOA Drug Mechanisms of Action 1.0 0.35 THAP1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_PHA-680632_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0164493 Subcommissural organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.588 A549_EED226_10然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0112117 GATA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8004 ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37117 tRNA methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.715 8833_TFAP2A_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.555046 EIF3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12515 K562_PF-573228_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161704 MXI1 ENCODE Transcription Factor Targets 1.0 null CL-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07738 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03951 ATF3 ENCODE Transcription Factor Targets 1.0 null GTEX-X261-0011-R6B-SM-4E3J8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.967057 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21878 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HOXB2::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.6651 GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 0.874846 BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.281257 SNX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.204 primary motor cortex (area M1, area 4)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.871647 inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.4231 K562_Ivosidenib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0378505 pterigoid muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.33949 MHHNB11 CCLE Cell Line Gene Expression Profiles -1.0 -2.75566 K562_S3I-201_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0165884 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 2 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54094 GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.17405 K562_Gandotinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145866 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 9680_UTP14A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.28791 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.42376 GSE158815_5_v_0_trib1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.78539 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57379 KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.364356 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-0426-SM-3K2BJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.42617 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H1-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-1126-SM-4DXV3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28493 GSE202434,GSE202438_13_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5191-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6709_PPY_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.636 RELA_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH2081 CCLE Cell Line Gene CNV Profiles 1.0 1.69439 GDM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.46858 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.320203 GTEX-PX3G-1026-SM-48TZW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943401 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.868199 MAX_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null r1 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26595 ventrolateral prefrontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16054 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.411 ADA complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.627 GTEX-R55F-0011-R8A-SM-2TF4F GTEx Tissue Sample Gene Expression Profiles 1.0 1.08918 tRNA splicing, via endonucleolytic cleavage and ligation GO Biological Process Annotations 2025 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.928846 H3K9me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_SNS-314 Mesylate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.03188 MIEN1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 6863_PSMC6_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.13177 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.46223 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nfe2l2_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.025339 PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE167218_1_v_0_hoxd12_mouse RummaGEO Gene Perturbation Signatures -1.0 null MDAMB436 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.948268 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.06749 TMUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43654 r11 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02387 GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 2.36367 FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5905 7441_RPL17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.901312 GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52984 NELFE ENCODE Transcription Factor Targets 1.0 null Perturb_11812_KO_Mcam_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.4107 GSE110524_2_v_5_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null CHP212 CCLE Cell Line Gene CNV Profiles -1.0 -2.41921 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16144 extracellular vesicular exosome GO Cellular Component Annotations 2015 1.0 null hsf1_19179333_rko_colon_carcinoma_lof_human_gpl6244_gse12762 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.033133 GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28815 colon_8b HPA Tissue Sample Gene Expression Profiles 1.0 1.05778 POLR2A ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTBP2 ENCODE Transcription Factor Targets 1.0 null NFYA ENCODE Transcription Factor Targets 1.0 null STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01203 metal ion binding GO Molecular Function Annotations 2015 1.0 null GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00611 H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MCF7_XAV-939_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.012345 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35474 E2F7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.3608 tRNA-splicing ligase complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GABPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9257 A549_Prednisone_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.02509 K562_Clevudine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146394 rectum_8d HPA Tissue Sample Gene Expression Profiles 1.0 0.966646 Acute Myeloid Leukemia_LAML_TCGA-AB-2969-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Navitoclax_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0190778 MCF7_Entinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0128335 MCF7_PCI-34051_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0118486 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain_Hippocampus_Middle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.943136 Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EM-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.78255 GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 1.28949 Perturb_13205_KO_Hdac3_ERP123505 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.58928 YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.66 YMB1 CCLE Cell Line Gene CNV Profiles -1.0 -1.34692 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21414 PRKCH Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 1.13732 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 UC-19-KX65_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238326 Tek TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.921 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SDF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34711 NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02496 MCF7_Mesna_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189149 USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein-containing complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 hsa-miR-4652-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 GSE235390_4_v_0_lurbinectedin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE108614,GSE108615_0_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28469 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -2.50937 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_InDel-F5-Pneo-r__CIC-1n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.43707 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.91338 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13422_KO_Fbxo4_SRP359195 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.71143 hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.275445 NCI-H720 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XUYS-0005-SM-47JZ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962129 GSE149366_1_v_0_sulconazole_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Fetal_Brain_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.53535 NCI-H2172 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.36557 GSE201042_2_v_1_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZBTB7A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4197 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25Z-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WZ811 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16244 HSF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.109 GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1376 Entorhinal area, medial part, dorsal zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37149 Lung Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.03917 K562_SB431542_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0311025 GTEX-VJYA-0001-SM-3NMDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.69031 epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05512 GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07458 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06004 GSE190384,GSE190386_0_v_8_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Z8-0726-SM-4GICB GTEx Tissue Sample Gene Expression Profiles 1.0 0.880193 GTEX-X4EP-3226-SM-3P5YR GTEx Tissue Sample Gene Expression Profiles 1.0 0.994961 K562_WP1066_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0225949 IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.96786 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2979 BCL3 ENCODE Transcription Factor Targets 1.0 null BCL6B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.7576 Perturb_17413_KO_p53|Plk4_SRP293099 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.34106 GABP-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null tRNA processing in the nucleus Reactome Pathways 2024 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234340_9_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_13195_KO_HDAC3_ERP127280 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.67458 6846_PSMA6_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.1354 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68325 superficial stratum of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01131 6533_POLR1A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.508827 Zbtb2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.9931 hepg2 HPA Cell Line Gene Expression Profiles 1.0 1.22097 Lung adenocarcinoma_LUAD_TCGA-55-7727-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_WP1066_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0208902 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 4110_IMPA2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.519628 10623_ZNF774_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.696876 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_12Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.07752 K562_Cyclocytidine HCl_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0210345 PMC11445528-44318_2024_208_MOESM5_ESM.xlsx-AA-geneSymbol_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null K562_TGX-221_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159621 GSE122067_3_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.979878 Lung squamous cell carcinoma_LUSC_TCGA-77-7335-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null (RS)-PPG DeepCoverMOA Drug Mechanisms of Action 1.0 0.23 SS18L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03986 Adrenocortical carcinoma_ACC_TCGA-OR-A5K5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Haustorium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.058 GSE173232_1_v_3_sf3b1_human RummaGEO Gene Perturbation Signatures -1.0 null IRF4 ENCODE Transcription Factor Targets 1.0 null K562_JNJ-7706621_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168705 GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38468 SP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.819673 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.11161 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Tazemetostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159022 Flp-In-T-REx cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.809 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null presubiculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36576 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.1502 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26907 ZBTB33_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.00795 heart GTEx Tissue Gene Expression Profiles -1.0 -0.893317 r9 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94433 MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.45572 VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1031 8873_THAP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.562797 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21211 TCF12_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_AC480_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154503 pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.64022 GSE165122_0_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null 17638893-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92572 MEL-JUSO Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.32476 9210_TPP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.789994 GTEX-V955-0004-SM-3NMDH GTEx Tissue Sample Gene Expression Profiles 1.0 1.64613 GTEX-WRHU-0006-SM-3MJF6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31656 PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2 Rummagene Transcription Factor Associations 2026 1.0 null extracellular region part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.71223 K562_Toremifene Citrate_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0291567 GSE205163,GSE205164_2_v_8_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.855162 HNF4A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05624 GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36985 PHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17912 GSE203308_1_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Leaf base TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.613 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.77345 Temporal association areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07374 posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12805 SOX2 ChEA Transcription Factor Targets 1.0 null GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67874 Lung squamous cell carcinoma_LUSC_TCGA-39-5024-01A-21R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tRNA processing Reactome Pathways 2024 1.0 null GSE128730_3_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59742 ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35299 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.22238 anteromedial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.59157 USF2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0011-R7a-SM-2HMJV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849186 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.94354 GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9337 GTEX-P4QT-1426-SM-3NMCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.09135 SOX3-22085726-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.979442 GTEX-NPJ8-0011-R4a-SM-2HML3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995589 ventral posterior lateral nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08011 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_TMP195_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0204875 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Tucidinostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0310017 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.17254 KIAA1522 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28081 ZNF85_01_126 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.15601 SB 225002 DeepCoverMOA Drug Mechanisms of Action -1.0 -1.82 GTEX-T5JW-0126-SM-4DM6K GTEx Tissue Sample Gene Expression Profiles 1.0 1.42098 Perturb_652_KD_lncRNA_097790_SRP093784 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.56831 TAF1 ENCODE Transcription Factor Targets 1.0 null POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160373_6_v_4_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_TCF3_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null OCILY19 CCLE Cell Line Gene Expression Profiles -1.0 -1.98639 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFIC_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9818_WDR3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.574534 t47d HPA Cell Line Gene Expression Profiles -1.0 -1.39967 MCF7_Rucaparib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143577 A704 CCLE Cell Line Gene CNV Profiles -1.0 -1.51397 USF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-1526-SM-4B66C GTEx Tissue Sample Gene Expression Profiles 1.0 0.856284 Perturb_5128_KD_Med4_SRP325525 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.62948 MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null colonrectum_d HPA Tissue Sample Gene Expression Profiles 1.0 1.17246 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02123 BTF3L4 Pathway Commons Protein-Protein Interactions 1.0 null rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.88292 CB-11-GB40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.200787 GSE125007,GSE125008_5_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.229153 Rootlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.02 CADO-ES1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.34964 TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4353 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null Islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12572 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null ARC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.492 Cell septum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.826 zinc acetate_homo sapiens_gds1617 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE202434,GSE202438_13_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.919582 Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8166_SMG5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.566622 Perturb_10200_KD_HNRNPUL1_ERP118119 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 ETV1-20927104-GIST48-HUMAN ChEA Transcription Factor Targets 2022 1.0 null VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.983985 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2980_KD_Mbnl1/Mbnl2_SRP057123 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.93866 H3K36me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8462_SSX2IP_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.506219 u698 HPA Cell Line Gene Expression Profiles 1.0 2.59673 GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retinoblastoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.925 layer 4 of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23768 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.14636 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2 Rummagene Transcription Factor Associations 2026 1.0 null REST_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RB1_KD_GSE50532_641_human_OSTEOBLASTS GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4QQ-01A-41R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57747 PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG Rummagene Transcription Factor Associations 2026 1.0 null extracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 K562_JNJ-7706621_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0217302 7461_RPL34_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.611332 Perturb_11819_KO_Olah_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.44651 Perturb_13206_OE_Klf3_SRP281992 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.34686 Ikzf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.3525 NAMALWA CCLE Cell Line Gene Expression Profiles 1.0 1.70386 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043575 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.73511 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13267_KO_chr2_SRP162484 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.689 GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.055 DC-93-RZ62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328658 KDM5A ENCODE Transcription Factor Targets 1.0 null GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.884179 MCF7_SB431542_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148309 CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Temsirolimus_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0305922 ELK1::HOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.0587 HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.846866 JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.279633 MCF7_Hesperadin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157954 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MCF7_Crizotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162687 KAT2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MKS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42154 Sarcoma_SARC_TCGA-DX-A6BB-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral posterior medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.48097 K562_ENMD-2076 L-Tartaric acid_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152003 GTEX-WHSE-0126-SM-3NMBT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37061 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null gill TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.688409 ST3GAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72185 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10194 GSE229914_2_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null K562_Regorafenib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0342066 USF1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5748_NOP2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.710859 BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.255075 CB-16-SY72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.201955 K562_M344_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142778 K562_Motesanib Diphosphate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172716 H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 6219_PES1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.881143 BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282144 Perturb_3834_KD_PRR14L_SRP162816 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.70545 5740_NOM1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.50294 POU2F1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null 7475_RPL5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.597178 Perturb_8606_KO_Mir132/212_SRP064164 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.35786 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00432 SMARCB1 ENCODE Transcription Factor Targets 1.0 null TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Triamcinolone Acetonide_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0124719 HOXA5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8531 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19906 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06132 ZNF611 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27981 MPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48166 Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35299 RAB3A_KO_GDS2483_701_mouse_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42279 GSE135350_2_v_7_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.200464 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_1813_KO_N4bp1_SRP255180 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.39236 GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18764 PMC10290283-biol-2022-0622-sm3.pdf-108-MSX1_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7436 K562_Glesatinib(MGCD265)_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0253276 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Navicular bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.962 Hyperplasia CTD Gene-Disease Associations 1.0 1.23868 CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB33_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymphnode_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.12125 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85I-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_ZM 447439_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179023 hsa-miR-4766-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 K562_Mocetinostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.017878 medial geniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04378 ETS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4204 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UCK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35191 ventral tegmental area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13685 EST1-17652178-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null MCF7_S-Ruxolitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.01855 fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.870504 Perturb_18562_KO_Lyl1/Tal1_SRP117185 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.74689 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.67434 periventricular stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.75009 Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2829 GSE190384,GSE190386_1_v_8_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-2126-SM-4BRVX GTEx Tissue Sample Gene Expression Profiles 1.0 1.00961 K562_Droxinostat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0278299 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 18378853-TableS1 GeneSigDB Published Gene Signatures 1.0 null TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_2-Methoxyestradiol_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0320806 GSE205163,GSE205164_3_v_7_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null ETS1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17762 GSE172020_0_v_3_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Fedratinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137558 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.57924 primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00139 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Orbital area, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19746 Lung adenocarcinoma_LUAD_TCGA-91-A4BD-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3263_KD_DDIT3_SRP335446 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.83074 GTEx Muscle 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures -1.0 -7.84278 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13423_KO|KD_Fbxo4|Hnrnpk_SRP359195 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.28841 Gill TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.076 H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-1283 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles 1.0 1.00522 H3K4me1_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null lateral posterior nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.929868 Microcephaly CTD Gene-Disease Associations 1.0 1.17728 Prostate adenocarcinoma_PRAD_TCGA-G9-6354-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TGFBR2_knockout_293_GSE46211 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.64768 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GATA1_G1E-ER4_mm9_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTHFD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2191 SW 982 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.880312 GTEX-N7MS-0926-SM-2HMIZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830425 GSE151090_2_v_1_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.257 GSE93309_2_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Mercaptopurine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0193766 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.975566 GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0341 Electron transfer flavoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.818 PPP3R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39832 MCF7_Decitabine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0105373 KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41318 supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12904 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 2.88009 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EC-86-EK93_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.26644 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE190384,GSE190386_6_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null K562_UNC0631_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0181552 CC-04-WK34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.233677 E2F4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA2 ENCODE Transcription Factor Targets 1.0 null EXOSC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31109 Perturb_11798_KO_Entpd8_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.73103 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE217776,GSE217829_4_v_6_sgf29_human RummaGEO Gene Perturbation Signatures 1.0 null KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4458 HOXA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.9681 Perturb_12318_KD_NRDE2_SRP161520 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.1172 extracellular region part GO Cellular Component Annotations 2015 1.0 null MDP1 Pathway Commons Protein-Protein Interactions 1.0 null Endoribonuclease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.612 MYC-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE160817_4_v_9_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null Outer dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.672 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21504 PADI4 ChEA Transcription Factor Targets 1.0 null cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05176 mammillary part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.424 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17238 HS 695T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21873 K562_Tozasertib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0131694 superficial stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04579 hsa-miR-4429 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 SEM CCLE Cell Line Gene Expression Profiles -1.0 -1.59213 BZW2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57175 Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.81728 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160083,GSE160084_1_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null 8660_TAF1D_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.568138 HS611T CCLE Cell Line Gene Expression Profiles 1.0 1.34977 GSE135350_3_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POU6F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2146 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039474 Supratrigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43696 S0-EE-XMWH_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.216431 MCF7_Ofloxacin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0110534 HOXB4-20404135-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null A549_Obatoclax Mesylate_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0138057 PAX5 ENCODE Transcription Factor Targets 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66534 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.949105 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles 1.0 1.05983 MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 5470_NAT10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.670458 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_AZD1480_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159898 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01759 K562_Roxadustat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0210571 GTEX-XGQ4-1326-SM-4GIDU GTEx Tissue Sample Gene Expression Profiles 1.0 1.13988 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852488 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0243 GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 0.999223 SNU626 CCLE Cell Line Gene Expression Profiles -1.0 -1.64429 TAF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Flocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70097 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IA-LM Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.97414 7166_RBM25_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.608512 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.02377 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.885302 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF3 ENCODE Transcription Factor Targets 1.0 null OCT4-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145990_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null t60-adrenal_consensus MoTrPAC Rat Endurance Exercise Training 1.0 3.02482 DA-20-VR86_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204017 SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06261 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null K562_Hesperadin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0311522 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26C-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Ofloxacin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168063 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.718945 BARHL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.1361 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934051 Lalistat1 DeepCoverMOA Drug Mechanisms of Action 1.0 0.31 TMEM184B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77458 VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.932284 ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.336 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1003 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r7 part of nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7977 ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03264 GSE202434,GSE202438_8_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null USF1_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79431 superficial gray layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03818 6555_POLR3A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.52134 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.06919 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null HCC70 CCLE Cell Line Gene CNV Profiles 1.0 1.51383 EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1276 VZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953581 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-EP-A2KA-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.864328 NCI-H1755 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.05492 7169_RBM28_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.591993 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pontocerebellar hypoplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.602 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null ELF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.3992 SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6595 MCF7_Bosutinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0124573 Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TWF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16358 GTEX-WH7G-0002-SM-4LVN9 GTEx Tissue Sample Gene Expression Profiles 1.0 2.27487 H4K91ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE125014_6_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null 2127_DDX51_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.728524 outer SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08275 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13456_OE_Smn1_SRP366489 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.50876 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Edinger-Westphal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12959 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17319 DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.0964 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFEB-21752829-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null DMS79 CCLE Cell Line Gene CNV Profiles 1.0 1.36141 Perturb_11814_KO_N4bp3_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.80897 TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5089_NIFK_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.607383 GTEX-WEY5-0526-SM-3GIKZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.13686 PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09393 H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles 1.0 2.3597 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pith TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.56 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null scale TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.251934 ELK4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4502 GSE202434,GSE202438_8_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF91_01_123 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.8994 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2726-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MHH-NB-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.863429 OCI-AML5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.933688 FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296234 Lung squamous cell carcinoma_LUSC_TCGA-85-A50Z-01A-21R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 10703_ZNRD1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.502043 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HI-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879825 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null K562_Carmofur_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0170975 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2098 Perturb_15785_KO_Crx_SRP047079 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.93713 HNF4A-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null superficial stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68014 GSE143944_1_v_0_ribociclib_human RummaGEO Drug Perturbation Signatures 1.0 null SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 1464_CDYL_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.784375 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.44982 GSE111138,GSE111149_1_v_0_runx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC12488502-41586_2025_9313_MOESM3_ESM.xlsx-ST-12-Supplementary_Table_12_PAX5_Interaction_Single_Genes_PAX5 Rummagene Transcription Factor Associations 2026 1.0 null lymph node HPA Tissue Gene Expression Profiles 1.0 1.05765 2125_DDX49_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.880684 extracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BE-71-AV63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203782 GTEX-T6MO-1626-SM-32QOM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12911 Thyroid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.12727 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.96785 4149_INTS4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.606397 Perturb_11846_KO_Tmem106b_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.01778 5733_NOL11_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.527044 Posterolateral visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28304 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8826_TEX10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.641352 GTEX-U4B1-0526-SM-4DXTK GTEx Tissue Sample Gene Expression Profiles 1.0 1.20639 A549_Dasatinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0124704 HME1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.554 cisplatin_homo sapiens_gds3910 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24221 aortic valve TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.807716 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null kidney HPA Tissue Protein Expression Profiles 1.0 0.941476 COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.892766 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_12075_OE_Prmt1_SRP134253 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.83311 HSF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4506 PSMD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.86953 TYKNU CCLE Cell Line Gene CNV Profiles 1.0 1.57929 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-2126-SM-4E3IB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12644 JURLMK1 CCLE Cell Line Gene CNV Profiles 1.0 2.10469 SP1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POYW-0726-SM-2XCEO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842745 GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07172 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1252 Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lymph node HPA Tissue Protein Expression Profiles 1.0 0.941476 10875_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.502261 K562_Thalidomide_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.022945 H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF205 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29923 MCF7_Hesperadin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0127314 aorta TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.814815 MCF7_Baricitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200622 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_2day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.09479 K562_PFI-1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.024527 GSE119978,GSE180930_0_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.898522 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BXPC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.845547 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.942392 ZR751 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.747863 USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null Koelliker-Fuse subnucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6243 GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 2.57838 CHD1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35494 K562_Fluorouracil_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157896 AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.01685 midbrain raphe nuclei Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.50942 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75626 H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SNU1079 CCLE Cell Line Gene Expression Profiles -1.0 -1.49788 GTEX-OIZH-0926-SM-48TBR GTEx Tissue Sample Gene Expression Profiles 1.0 0.943039 K562_Cerdulatinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0212547 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80823 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06482 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GCM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03283 DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.51999 AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231285 PARP4 Pathway Commons Protein-Protein Interactions 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 RERF-LC-MS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35801 GSE216043_11_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231648_1_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null substantia innominata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.913167 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53221 Cco TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.815 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09648 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.66646 Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4K8ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE151494_1_v_9_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null bp86 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.778 MCF7_TAK-901_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153656 MCF7_AZD1480_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0117003 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RE-62-FC93_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.30277 GSE202434,GSE202438_3_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WYJK-0126-SM-3NMAB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824065 Ire1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.562 HSC4 CCLE Cell Line Gene CNV Profiles -1.0 -1.49489 CEBPB_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_MC1568_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0209262 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95317 BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A656-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Phenobarbital CTD Gene-Chemical Interactions 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Archease InterPro Predicted Protein Domain Annotations 1.0 null BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.262427 ACTR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27473 PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-FL_YAP_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACOT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17855 NRD1 Pathway Commons Protein-Protein Interactions 1.0 null GSE62843,GSE64370_0_v_3_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null Infralimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58568 GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17567 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Tie2 kinase inhibitor_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153373 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28529 GSE117643_1_v_0_irx5_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_ENMD-2076 L-Tartaric acid_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0111136 Perturb_9412_KD_Pcbp1/Platr18_SRP251371 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.87273 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16268 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null A549_PHA-680632_100nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132855 PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01415 MCF7_JQ1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0205169 GSE225218_2_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Right nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.721 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08866 ncrna processing GO Biological Process Annotations 2015 1.0 null NFYA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12572 GSE252857_1_v_0_klf15_mouse RummaGEO Gene Perturbation Signatures 1.0 null spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02788 proteasome regulatory particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.26239 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null 9443_TWISTNB_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.642191 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186440,GSE186443_2_v_5_daxx_human RummaGEO Gene Perturbation Signatures -1.0 null FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.554664 POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null vh2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.568 GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.67435 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.851702 full GeneRIF Biological Term Annotations 1.0 null cas1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.734 CCNT2 ENCODE Transcription Factor Targets 1.0 null A549_EED226_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161804 Type 1 diabetes mellitus_Thymic epithelial cell_GSE11 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.34614 ZNF829 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26126 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11335 MCF7_UNC0631_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00875181 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7 Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 part of vagal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19186 IRF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A172 CCLE Cell Line Gene CNV Profiles -1.0 -1.40406 Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JHOS2 CCLE Cell Line Gene CNV Profiles 1.0 1.42062 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 2113_DDX24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.640549 ectoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.089648 GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.3325 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null SNU668 CCLE Cell Line Gene Expression Profiles -1.0 -1.74196 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.937033 TCF3 ENCODE Transcription Factor Targets 1.0 null Perturb_12036_KD_Prmt6_SRP131294 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AP-1 adaptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.739 H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null