association	dataset	threshold value	standardized value
Nucleolar chromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.813
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.4649
CRCGN017_MCF10A.WT.HP_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21215
F36P	CCLE Cell Line Gene CNV Profiles	1.0	1.39852
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.9868
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.029
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5152-01A-02R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4254
GOS3	CCLE Cell Line Gene CNV Profiles	1.0	1.48546
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	151.072
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.9172
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72463
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.23802
tissue development	GO Biological Process Annotations 2015	1.0	null
protein complex assembly	GO Biological Process Annotations 2015	1.0	null
adipose tissue	GTEx Tissue Gene Expression Profiles	1.0	0.943798
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5044
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.12101
SPI1	ENCODE Transcription Factor Targets	1.0	null
chromatin organization	GO Biological Process Annotations 2015	1.0	null
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.9385
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WT-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3140-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Gonadal dysgenesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89124
nucleus	GO Cellular Component Annotations 2023	1.0	null
male gamete generation	GO Biological Process Annotations 2015	1.0	null
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61993
Brain Lower Grade Glioma_LGG_TCGA-DB-5275-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.42311
GSE188570,GSE188571_3_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MO-91 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.741
496100353_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.72812
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.06901
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87965
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.36
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.524
X-linked reticulate pigmentary disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
CHAGOK1	CCLE Cell Line Gene CNV Profiles	1.0	1.45897
Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GS-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	219.919
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6402
SIN3A	ENCODE Transcription Factor Targets	1.0	null
cellular macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
d36	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.934
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.61882
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92893
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68272
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NO-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
uterus	GTEx Tissue Gene Expression Profiles	-1.0	-1.01167
PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37143
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	8.4939
PR cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.765316
bladder	GTEx Tissue Gene Expression Profiles	-1.0	-1.01167
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.6893
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9622
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9628
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05872
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
biological_process	GO Biological Process Annotations 2015	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.03208
Pek	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.805
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40226
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63276
DEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TFAP2C	JASPAR Predicted Transcription Factor Targets	1.0	null
ZBTB33_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6243
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.42273
SP1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100384_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.52064
MYC	ENCODE Transcription Factor Targets	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.09045
LS180	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4048
CAS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
gonadal mesoderm development	GO Biological Process Annotations 2015	1.0	null
Clitoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.838
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
TF1	CCLE Cell Line Gene CNV Profiles	1.0	1.88232
ZBTB33_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sertoli cell-only syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Klinefelter syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.514
NCIH810	CCLE Cell Line Gene CNV Profiles	1.0	2.71521
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1106
hsa-miR-758	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-6798-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78375
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.709852
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
Pachytene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.819
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5357
496100528_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.01675
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hs27	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.803
hsa-miR-4680-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90749
CUX1	ChEA Transcription Factor Targets	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25592
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7218
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3328
Peritubular contractile cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13977
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50623
Villous cytotrophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.576
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.666
Kidney Chromophobe_KICH_TCGA-KN-8430-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57912
pituitary	GTEx Tissue Gene Expression Profiles	1.0	0.98856
testis	HPA Tissue Protein Expression Profiles	1.0	0.917838
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32037
COV504	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42651
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14272
macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
Scrotum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	10.0115
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93946
reproductive structure development	GO Biological Process Annotations 2015	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78726
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.748523
developmental process involved in reproduction	GO Biological Process Annotations 2015	1.0	null
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88706
protein-dna complex subunit organization	GO Biological Process Annotations 2015	1.0	null
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.69854
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60683
KM-12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.18
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7432
Autosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.365
Partington syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
496100361_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.79834
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	0.917838
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31685
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29627
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1139
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.91481
ELK1	JASPAR Predicted Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0246
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27814
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.125
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.47874
CRCGN010_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06074
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	162.164
Prostate adenocarcinoma_PRAD_TCGA-XJ-A83F-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHH2	CCLE Cell Line Gene CNV Profiles	1.0	1.55739
GSE184087_4_v_5_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.552967
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Age related macular degeneration 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.676
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3YS-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4640-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
MYC	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4382-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOSL2	ENCODE Transcription Factor Targets	1.0	null
cell differentiation	GO Biological Process Annotations 2015	1.0	null
U343	CCLE Cell Line Gene CNV Profiles	1.0	1.3679
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.1162
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.627
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4355
RXRA	ENCODE Transcription Factor Targets	1.0	null
Varicocele	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0666
RXRA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04971
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23741
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.69077
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RW-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.468
PMC3921136-CIN-13-2014-021-s001.pdf-210-TRPS1_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
nucleus	GO Cellular Component Annotations 2015	1.0	null
NCIH2196	CCLE Cell Line Gene CNV Profiles	1.0	1.3656
cellular component assembly	GO Biological Process Annotations 2015	1.0	null
laminin-10 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.579
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hair root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08153
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Testicular somatic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.0122
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24677
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.47175
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medullary thyroid carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
IGR1	CCLE Cell Line Gene CNV Profiles	1.0	1.46255
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30697
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.8333
spermatogenesis	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7148-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.871497
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6394
CRCGN015_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23141
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93437
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56199
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.16854
CAL33	CCLE Cell Line Gene CNV Profiles	1.0	1.36536
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46193
intracellular part	GO Cellular Component Annotations 2015	1.0	null
SNU1076	CCLE Cell Line Gene CNV Profiles	1.0	2.26938
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25V-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.40697
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.65376
Spermatogenic failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
Developmental and epileptic encephalopathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.764
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nerve	GTEx Tissue Gene Expression Profiles	1.0	1.27251
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69009
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3488
Lung adenocarcinoma_LUAD_TCGA-55-1592-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.99124
vagina	GTEx Tissue Gene Expression Profiles	-1.0	-1.01167
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72135
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.772503
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5356-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.55487
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chromosomal duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.2497
YH13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37586
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0516
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1978
Disorder of sexual development	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91851
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A115-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6022-01A-21R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5566
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23502
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-4R-AA8I-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.62068
PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
anatomical structure development	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71151
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43Y-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.3098
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.26193
POLR2A	ENCODE Transcription Factor Targets	1.0	null
PMC8600817-12951_2021_1120_MOESM2_ESM.xlsx-Table_S4-Table_S4_Pan_PPAR-iMSC-EV-induced_differentially_expressed_genes_in_fatty_acid-treated_HepG2_cells_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
496100479_FWM_no dementia_TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.25757
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
protein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89046
hsa-miR-1914	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
JUND	ENCODE Transcription Factor Targets	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95542
mesenchyme development	GO Biological Process Annotations 2015	1.0	null
hsa-miR-1298	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mesoderm development	GO Biological Process Annotations 2015	1.0	null
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	1.0	7.21239
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4901
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.7124
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4923
Lung squamous cell carcinoma_LUSC_TCGA-39-5021-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A7US-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein-dna complex assembly	GO Biological Process Annotations 2015	1.0	null
TCF12_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A	JASPAR Predicted Transcription Factor Targets	1.0	null
ZNF784	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2758
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3007
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07862
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	157.505
nucleosome organization	GO Biological Process Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2935-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
developmental process	GO Biological Process Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42P-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44093
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.6538
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4065
Meiotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.128
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
nucleosome assembly	GO Biological Process Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A8AZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
multicellular organismal reproductive process	GO Biological Process Annotations 2015	1.0	null
MPP-89	COSMIC Cell Line Gene Mutation Profiles	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Mesothelioma_MESO_TCGA-TS-A7PB-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism developmental process	GO Biological Process Annotations 2015	1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6362
Chromatin	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2583
gamete generation	GO Biological Process Annotations 2015	1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.12148
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20108
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.9131
VPRBP_KD_GDS4829_90_human_DU145 prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5072-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7939
Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A9DB-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AB-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
162 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.068
Nucleosome assembly protein (NAP)	InterPro Predicted Protein Domain Annotations	1.0	null
hsa-miR-4753-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
organelle	GO Cellular Component Annotations 2015	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955454
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03481
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0793
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9156
Azoospermia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
Gonadoblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.983
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.24509
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.38835
fallopian tube	GTEx Tissue Gene Expression Profiles	-1.0	-1.01167
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.8059
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-K7-A5RG-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5528
HEC108	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32117
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60275
Nucleolus organizer region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.956
TCF12	ENCODE Transcription Factor Targets	1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8727
cell part	GO Cellular Component Annotations 2015	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.821
SOX11	ChEA Transcription Factor Targets	1.0	null
EW8	CCLE Cell Line Gene CNV Profiles	1.0	1.47749
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
cellular component organization	GO Biological Process Annotations 2015	1.0	null
H3K9me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100526_TCx_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11386
Turner syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
APP	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77744
hsa-miR-580	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
KMS21BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40746
G402	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3712
MEG01	CCLE Cell Line Gene CNV Profiles	1.0	1.84442
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78795
Spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.372
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9364
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gonocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.113
reproductive process	GO Biological Process Annotations 2015	1.0	null
single organism reproductive process	GO Biological Process Annotations 2015	1.0	null
cellular developmental process	GO Biological Process Annotations 2015	1.0	null
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6371
FOSL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medullary carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Decidual stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
PMC7825356-8844261.f3.docx-107-TGIF2LY_TGIF2LY	Rummagene Transcription Factor Associations 2026	1.0	null
stomach	HPA Tissue Protein Expression Profiles	1.0	1.75067
Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
MAX	Pathway Commons Protein-Protein Interactions	1.0	null