association	dataset	threshold value	standardized value
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6148
MTHFS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15163
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.442
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5925
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5406
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.5
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0806
Phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
Resolution of Sister Chromatid Cohesion	Reactome Pathways 2024	1.0	null
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0711
RASSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15223
GGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96437
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.0683
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2033
SLC39A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07305
FAM72B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71919
FADS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09092
Cell Cycle	Reactome Pathways 2024	1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1529
PMC11392820-41556_2024_1475_MOESM3_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Expression_level_of_OTX2_targeted_genes_n_999_related_to_Figure_6_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8724
SRSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41528
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.396
ZBTB46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11342
AKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34636
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cytoskeleton	GO Cellular Component Annotations 2025	1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01491
HOOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67357
SEC63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94623
Antiviral mechanism by IFN-stimulated genes	Reactome Pathways 2024	1.0	null
RAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17238
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GINS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.701
Intra-Golgi and retrograde Golgi-to-ER traffic	Reactome Pathways 2024	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8177
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Macroautophagy	Reactome Pathways 2024	1.0	null
Cellular responses to stimuli	Reactome Pathways 2024	1.0	null
Developmental Biology	Reactome Pathways 2024	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LPAR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05882
Transport of connexons to the plasma membrane	Reactome Pathways 2024	1.0	null
Interferon Signaling	Reactome Pathways 2024	1.0	null
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAB6D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27261
RHO GTPases activate IQGAPs	Reactome Pathways 2024	1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
M Phase	Reactome Pathways 2024	1.0	null
Salmonella infection	KEGG Pathways 2026	1.0	null
Supramolecular fiber	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Retina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.117
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9911
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
DHRS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63573
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLEKHG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45158
CBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23501
Null cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.833
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.5
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9788
ZNF701	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63261
Assembly and cell surface presentation of NMDA receptors	Reactome Pathways 2024	1.0	null
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
Large granular lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.833
Nervous system development	Reactome Pathways 2024	1.0	null
Transmission across Chemical Synapses	Reactome Pathways 2024	1.0	null
L1CAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12821
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7408
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.233
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6512
Alzheimer disease	KEGG Pathways 2026	1.0	null
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gap junction trafficking and regulation	Reactome Pathways 2024	1.0	null
HOXB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94591
DCAF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46887
SLAIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69929
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69236
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.833
ZNF641	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36374
Huntington disease	KEGG Pathways 2026	1.0	null
Phagosome	KEGG Pathways 2026	1.0	null
RPL36AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18353
Gut	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.233
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126776_0_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
LEMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42314
Retinal vasculopathy with cerebral leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
Spindle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MHC class II antigen presentation	Reactome Pathways 2024	1.0	null
MIDEAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33774
C2CD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42816
Type I interferon receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.532
PTRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19992
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.833
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9961
Mitotic spindle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
mitotic spindle	GO Cellular Component Annotations 2025	1.0	null
Parkinson disease	KEGG Pathways 2026	1.0	null
polymeric cytoskeletal fiber	GO Cellular Component Annotations 2025	1.0	null
MIOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54914
Pathways of neurodegeneration - multiple diseases	KEGG Pathways 2026	1.0	null
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.757
RRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13684
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Motor proteins	KEGG Pathways 2026	1.0	null
H4C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54457
Mononuclear cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.8701
Transport to the Golgi and subsequent modification	Reactome Pathways 2024	1.0	null
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DNAJC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90933
USP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86281
PKR-mediated signaling	Reactome Pathways 2024	1.0	null
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74386
Adaptive Immune System	Reactome Pathways 2024	1.0	null
Mitotic G2-G2/M phases	Reactome Pathways 2024	1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1027
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3791
Post-translational protein modification	Reactome Pathways 2024	1.0	null
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrion-derived vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
COPI-dependent Golgi-to-ER retrograde traffic	Reactome Pathways 2024	1.0	null
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Vesicle-mediated transport	Reactome Pathways 2024	1.0	null
GPATCH11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86556
Mononuclear phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3116
Intercellular bridge	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitotic Metaphase and Anaphase	Reactome Pathways 2024	1.0	null
SPARC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43192
NT5DC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7047
GSE139540_0_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LDLRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54042
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4914
FOXS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35934
ZNF516	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27076
Autophagy	Reactome Pathways 2024	1.0	null
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AGPAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80033
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0044
Separation of Sister Chromatids	Reactome Pathways 2024	1.0	null
Hemostasis	Reactome Pathways 2024	1.0	null
GSE159473_0_v_1_eif5a2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8938
microtubule cytoskeleton	GO Cellular Component Annotations 2025	1.0	null
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCARB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89102
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CSNK1A1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80478
DHX36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56982
HCMV Early Events	Reactome Pathways 2024	1.0	null
GGCX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84393
Signal Transduction	Reactome Pathways 2024	1.0	null
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MRGBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17353
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3037
Activation of NMDA receptors and postsynaptic events	Reactome Pathways 2024	1.0	null
Primitive endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7404
Activation of AMPK downstream of NMDARs	Reactome Pathways 2024	1.0	null
Signaling by Rho GTPases	Reactome Pathways 2024	1.0	null
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EML4 and NUDC in mitotic spindle formation	Reactome Pathways 2024	1.0	null
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.833
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Supramolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Factors involved in megakaryocyte development and platelet production	Reactome Pathways 2024	1.0	null
NAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12169
Golgi-to-ER retrograde transport	Reactome Pathways 2024	1.0	null
Neuronal System	Reactome Pathways 2024	1.0	null
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.293
OTX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1563
TMEM191B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16763
GNAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70501
RHO GTPases Activate Formins	Reactome Pathways 2024	1.0	null
Polymeric cytoskeletal fiber	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
COPI-mediated anterograde transport	Reactome Pathways 2024	1.0	null
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Reactome Pathways 2024	1.0	null
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.329
PKMYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56874
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PITX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81416
Metabolism of proteins	Reactome Pathways 2024	1.0	null
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ABT-751	DGIdb Drug Targets 2026	1.0	3.11365
ZNF674	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80907
Recycling pathway of L1	Reactome Pathways 2024	1.0	null
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8631
PYGB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84002
FBXO45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77553
Viral Infection Pathways	Reactome Pathways 2024	1.0	null
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4901
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	1.0	7.17818
ZNF843	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1833
chr18_47492_G_A_b38	GTEx eQTL 2025	1.0	2.48739
RBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55584
CIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1548
Translocation of SLC2A4 (GLUT4) to the plasma membrane	Reactome Pathways 2024	1.0	null
CCDC113	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50246
GSE197630_1_v_0_ruvbl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ADAM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40635
COPI-independent Golgi-to-ER retrograde traffic	Reactome Pathways 2024	1.0	null
Microtubule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Amyotrophic lateral sclerosis	KEGG Pathways 2026	1.0	null
DTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6097
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3237
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7756
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5965
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0846
Cytokine Signaling in Immune system	Reactome Pathways 2024	1.0	null
GSE131649_6_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HAPSTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53655
Cilium Assembly	Reactome Pathways 2024	1.0	null
TRMT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37372
CNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53423
ZNF30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42077
PPM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36129
Monocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
B-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
Disease	Reactome Pathways 2024	1.0	null
KLHDC7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63323
MPLKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94046
MPDU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16912
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1146
PMC8639438-41388_2021_1938_MOESM3_ESM.xlsx-ZNF545-IP_group-Gene_Name_ZFP82	Rummagene Transcription Factor Associations 2026	1.0	null
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
ANAPC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78599
GSE114685_1_v_0_grin2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
NADSYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70836
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Infectious disease	Reactome Pathways 2024	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6165
Prion disease	KEGG Pathways 2026	1.0	null
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gap junction	KEGG Pathways 2026	1.0	null
PITX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4526
UQCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09754
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9058
Gap junction assembly	Reactome Pathways 2024	1.0	null
RCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06661
LMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06828
ZNF687	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84001
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4711
LHX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60777
RHO GTPase Effectors	Reactome Pathways 2024	1.0	null
PODXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94225
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37816
DAXX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41067
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	176.203
NEK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20933
HNRNPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07198
Selective autophagy	Reactome Pathways 2024	1.0	null
PPFIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92597
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5616
Natural killer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.833
GSE125219,GSE125221_4_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
spindle	GO Cellular Component Annotations 2025	1.0	null
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4114
MHC protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.161
IgSF CAM signaling	KEGG Pathways 2026	1.0	null
guanyl ribonucleotide binding	GO Molecular Function Annotations 2025	1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1056
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PLPPR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02208
LHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84531
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1631
MIER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92521
Cellular responses to stress	Reactome Pathways 2024	1.0	null
ER to Golgi Anterograde Transport	Reactome Pathways 2024	1.0	null
BRWD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67141
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
NAAA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45583
SIRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90128
GLOD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03445
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.833
ACAA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21129
MEIS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77985
GATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08335
SKP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44159
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8929
Carboxyterminal post-translational modifications of tubulin	Reactome Pathways 2024	1.0	null
HPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15396
Nuclear Envelope (NE) Reassembly	Reactome Pathways 2024	1.0	null
Retinitis pigmentosa 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
CXADR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77458
CEBPE	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5527
PHACTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47187
ZNF814	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30862
CALCOCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39741
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3201
Membrane Trafficking	Reactome Pathways 2024	1.0	null
STXBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43956
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
microtubule	GO Cellular Component Annotations 2025	1.0	null
RMND5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16076
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9184
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4143
Marrow cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
MTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5489
MED11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47356
CFAP298	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50696
ORMDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43218
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1978
LIN7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22085
Immune System	Reactome Pathways 2024	1.0	null
The role of GTSE1 in G2/M progression after G2 checkpoint	Reactome Pathways 2024	1.0	null
SLC18A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45393
EDA2R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54459
SAMD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59913
Kinesins	Reactome Pathways 2024	1.0	null
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
SEMA7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76293
CRLF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68542
SSTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53084
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	Reactome Pathways 2024	1.0	null
GTP binding	GO Molecular Function Annotations 2025	1.0	null
IFFO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40232
DMRT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7295
SYCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13939
B2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41528
ZNF112	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6619
G2/M Transition	Reactome Pathways 2024	1.0	null
SAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5956
CISD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78149
Neurotransmitter receptors and postsynaptic signal transmission	Reactome Pathways 2024	1.0	null
SIX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73998
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NEIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06388
ZNF860	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55332
Aggrephagy	Reactome Pathways 2024	1.0	null
HSFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17109
RWDD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37059
HCMV Infection	Reactome Pathways 2024	1.0	null
BMAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6874
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4522
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4018
GSE224294_4_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	Reactome Pathways 2024	1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPP3R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11573
CABIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01379
TMX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70805
ZNF217	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66657
ZNF280C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16951
Axon guidance	Reactome Pathways 2024	1.0	null
PMC10806738-mmc2.xlsx-Table_S1-Table_S1_Table_of_significantly_adjusted_p-valued_0_05_up-regulated_genes_log2FC_1_in_MAX-R60Q_transfected_HEK293_cells_relative_to_MAX-WT_transfected_cells_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZFPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51232
RBM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18577
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2763
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Blood platelet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
Supramolecular polymer	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
FAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12717
Cell Cycle, Mitotic	Reactome Pathways 2024	1.0	null
Recruitment of NuMA to mitotic centrosomes	Reactome Pathways 2024	1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2543
ZNF784	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96256
SMAD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5566
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0975
AP3M2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45016
ZNF277	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36372
Sealing of the nuclear envelope (NE) by ESCRT-III	Reactome Pathways 2024	1.0	null
GSE175787_8_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.548
Eye	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.117
Malignant spindle cell melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DENND4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57904
Mitotic Prometaphase	Reactome Pathways 2024	1.0	null
SWI5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48808
Asparagine N-linked glycosylation	Reactome Pathways 2024	1.0	null
Blood plasma	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
GOLPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62112
Placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.5
Mitotic Anaphase	Reactome Pathways 2024	1.0	null
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.833
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3756
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1394
Gap junction trafficking	Reactome Pathways 2024	1.0	null
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0175
GSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2855
PMC4595011-pgen.1005555.s003.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Organelle biogenesis and maintenance	Reactome Pathways 2024	1.0	null
Post NMDA receptor activation events	Reactome Pathways 2024	1.0	null
Ltk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.506
RSRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20986
Sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.117
Pathogenic Escherichia coli infection	KEGG Pathways 2026	1.0	null
L1CAM interactions	Reactome Pathways 2024	1.0	null
Mitotic spindle microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.174