association dataset threshold value standardized value primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3051 ncrna processing GO Biological Process Annotations 2015 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35259 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.896587 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67422 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RARA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.6306 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7819-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1996 nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.799 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ESRRA ENCODE Transcription Factor Targets 1.0 null GSE224294_3_v_2_ngly1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE128844_0_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE226249_2_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WH7G-0326-SM-3NMBH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95218 GSE163240_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null arteriosclerosis GWASdb SNP-Disease Associations 1.0 1.50906 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Arterial system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.635 GTEX-TKQ2-0426-SM-4DXUO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07082 NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.96964 GTEX-QMRM-1126-SM-447BN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827944 K562_Tozasertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0197383 GSE169617_1_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Baricitinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144708 Lung squamous cell carcinoma_LUSC_TCGA-39-5031-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Tacedinaline_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0187838 Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.83083 SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174498,GSE174500_3_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22768 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7060-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ7-0011-R9a-SM-2TC5R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41141 GSE76425_0_v_10_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 K562_Alisertib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158794 K562_XAV-939_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0309741 ELK4 ENCODE Transcription Factor Targets 1.0 null HERPUD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14235 Adrenocortical carcinoma_ACC_TCGA-OR-A5JA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-129-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226249_0_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-2355-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMARCA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01311 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IKZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7051 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924306 K562_Cimetidine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173388 USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5K1-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MUTYH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10333 GSE213588_8_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null ribonucleotide binding GO Molecular Function Annotations 2015 1.0 null GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.955292 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47542 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MED17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35432 MAFF ENCODE Transcription Factor Targets 1.0 null MCF7_Quisinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.020386 Lung adenocarcinoma_LUAD_TCGA-78-7156-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92185 GTEX-S95S-0008-SM-4AT5M GTEx Tissue Sample Gene Expression Profiles 1.0 1.93204 K562_Prednisone_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0263623 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A6MB-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased mean corpuscular hemoglobin concentration MGI Mouse Phenotype Associations 2023 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PGR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8435 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE103068_0_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Triglyceride levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.769897 ZNF528 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4448 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38215 PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.907014 CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.84831 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34852 A549_Tacedinaline_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0106961 Lung adenocarcinoma_LUAD_TCGA-55-7726-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ganglion TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NY-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_JQ1_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142267 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE182179_0_v_3_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null K562_UNC0379_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152081 VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.825608 H3K9ac_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25871 hsa-miR-1245 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4717-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GSE158738_0_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null MEOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.986 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.842843 VZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04353 A549_Roxadustat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142208 EP300_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-0326-SM-3DB8P GTEx Tissue Sample Gene Expression Profiles 1.0 0.939303 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EP-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Barasertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156583 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26211 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PHOX2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.6682 Lung adenocarcinoma_LUAD_TCGA-69-7760-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1065 GTEX-WZTO-0011-R4A-SM-3NMC7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02825 K562_Valproic acid sodium salt_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0400447 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CB-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Belinostat_SW1417 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0354005 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175787_5_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null RXRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.2943 GTEX-UJMC-2026-SM-3GADR GTEx Tissue Sample Gene Expression Profiles 1.0 0.977305 GSE226249_2_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-T2IS-0011-R5A-SM-32QP4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32028 BCLAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A8BT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null D283MED CCLE Cell Line Gene CNV Profiles -1.0 -1.72953 PHF8 ENCODE Transcription Factor Targets 1.0 null K562_Curcumin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178407 GSE239844_7_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WFG7-0008-SM-4LMKB GTEx Tissue Sample Gene Expression Profiles 1.0 1.87555 Cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Rectum adenocarcinoma_READ_TCGA-EI-6883-01A-31R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FE-64-KC49_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218173 SRF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null A549_IOX2_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0149223 Developmental disorder of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 A549_Aminoglutethimide_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153797 FZD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43971 SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3071 K562_Capecitabine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0256825 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q4-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JW-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE221577_2_v_0_pik3r1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.8232 USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null basal ganglia disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 K562_Dacinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0951536 PRKAR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14249 GSE179693,GSE179694_4_v_2_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A Rummagene Transcription Factor Associations 2026 1.0 null GSE140936,GSE140938_2_v_1_slfn11_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U3ZH-1426-SM-4DXSR GTEx Tissue Sample Gene Expression Profiles 1.0 1.30911 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7LX-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33956 GTEX-XMD1-0011-R2B-SM-4AT5N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869284 POTEI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29565 GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11319 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22846 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06203 Prostate gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13864 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00604 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VMRCRCZ CCLE Cell Line Gene CNV Profiles 1.0 2.59998 K562_Avagacestat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185383 Mesothelioma_MESO_TCGA-SC-A6LR-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4343-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10834420-12276_2023_1140_MOESM2_ESM.xls-ST12-Unnamed_5_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30035 amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.937397 PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0011-R7A-SM-2HMJP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08132 GTEX-WWYW-0011-R8A-SM-3NB3S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20977 K562_Tranylcypromine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0164764 YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HC-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0953 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4795-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-W5X1-0526-SM-3GILH GTEx Tissue Sample Gene Expression Profiles 1.0 1.0038 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 0.948303 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE174701_5_v_6_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE195663_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7871-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OIZH-0326-SM-2HMKC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828762 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A264-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_UNC0631_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155561 K562_PFI-1_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0236457 GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13075 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23589 Acute Myeloid Leukemia_LAML_TCGA-AB-2972-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.74781 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-6720-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Thalidomide_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146964 GTEX-XPVG-0326-SM-4B653 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33433 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.62897 SKMEL31 CCLE Cell Line Gene CNV Profiles 1.0 1.50717 FOXD4L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16308 Kidney Chromophobe_KICH_TCGA-KL-8344-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_BMS-911543_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0235038 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66981 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3311-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.918791 small molecule binding GO Molecular Function Annotations 2015 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_MK-5108_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.024433 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.886796 MCF7_Tranylcypromine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0213963 YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Phenytoin (sodium)_SW480 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0137294 GTEX-S4UY-0926-SM-4AD6O GTEx Tissue Sample Gene Expression Profiles 1.0 1.29221 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69984 NANOG ENCODE Transcription Factor Targets 1.0 null central nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SRGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04486 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 0.988686 organelle LOCATE Predicted Protein Localization Annotations 1.0 null MCF7_EED226_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154274 CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE165334_2_v_0_dabrafenib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Fluorouracil_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0216007 dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.938488 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE175787_4_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-DX-A6YV-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anteromedial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.923047 MOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21978 EP300_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-1926-SM-3GADS GTEx Tissue Sample Gene Expression Profiles 1.0 0.915483 GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.985547 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XK95-0008-SM-4AT5G GTEx Tissue Sample Gene Expression Profiles 1.0 0.939528 solitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10131 GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26931 GSE213588_8_v_1_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.69963 GTEX-OXRK-0826-SM-2HMK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840721 A549_CYC116_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0129073 stroke GAD Gene-Disease Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65F-01A-21R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_BMS-911543_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0203821 YY1_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tobacco use disorder GAD Gene-Disease Associations 1.0 null glycosyl compound biosynthetic process GO Biological Process Annotations 2023 1.0 null GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4223 GSE213588_10_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Rigosertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172887 GSE195663_0_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Iniparib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.012234 K562_Gandotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0220599 GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.18461 GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02487 decreased circulating serum albumin level MGI Mouse Phenotype Associations 2023 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98664 PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr7_72744727_T_C_b38 GTEx eQTL 2025 1.0 3.42817 TAL1 ENCODE Transcription Factor Targets 1.0 null GTEX-S32W-2126-SM-2XCB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0037 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2YK-2226-SM-32QPT GTEx Tissue Sample Gene Expression Profiles 1.0 1.85172 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5558-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07229 chr7:72251122:I GTEx eQTL 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A42Z-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A493-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles 1.0 2.3038 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B6-01A-21R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Regorafenib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151861 K562_MC1568_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0169121 SP1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPINT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41054 K562_XAV-939_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0258977 A549_AR-42_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151493 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-8156-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-8198-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6V9-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T6MN-0008-SM-4DM7H GTEx Tissue Sample Gene Expression Profiles 1.0 2.34918 GSE201657_0_v_1_ash2l_human RummaGEO Gene Perturbation Signatures 1.0 null K562_PD98059_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154991 H3K79me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93W-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_PFI-1_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0232269 PHB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18477 PROP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.8415 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8062-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NFYA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11704 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inner CP in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20045 BATF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H8-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DUXA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.0407 K562_Resveratrol_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153701 REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ4-2726-SM-3P61A GTEx Tissue Sample Gene Expression Profiles 1.0 1.32383 CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-1426-SM-4DXTX GTEx Tissue Sample Gene Expression Profiles 1.0 1.10127 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03621 CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A2QG-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4768-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XRN2 ChEA Transcription Factor Targets 1.0 null H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null K562_Costunolide_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0193854 GSE114883_1_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.18535 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 K562_GSK1070916_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0212602 GTEX-WEY5-1326-SM-3GILS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02172 GTEX-P4QT-1726-SM-2S1NQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.20203 MCF7_GSK1070916_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168453 Rectum adenocarcinoma_READ_TCGA-EI-6514-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_AC480_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170307 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43956 GSE138050,GSE148257_1_v_2_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Alisertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0110591 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H1-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47584 lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.2005 ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-1026-SM-47JXD GTEx Tissue Sample Gene Expression Profiles 1.0 1.38633 GSE175787_13_v_2_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Naproxen_SW480 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0245297 GSE213588_8_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.26751 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.42237 YY1 ENCODE Transcription Factor Targets 1.0 null SMAGP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21124 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.955898 RXRA ENCODE Transcription Factor Targets 1.0 null GTEX-V1D1-0526-SM-4JBGW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989643 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null basolateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21561 PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Trametinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0111079 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Mesna_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0220548 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_10_v_6_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null PHF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96607 GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54049 MCF7_UNC0379_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0232838 REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null K562_XAV-939_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0290632 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44P-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4508 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE194396,GSE194429_1_v_0_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Fasudil_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158407 H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 PSMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91674 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_RG108_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158744 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33153 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5631-01A-01R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Azacitidine_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0105912 GTEX-XPVG-0826-SM-4B654 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962189 globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10587 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59345 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.65842 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.49054 A549_ENMD-2076 L-Tartaric acid_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162305 GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38957 GTEX-P4QT-0226-SM-3LK68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.47052 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.12067 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.867201 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.00601 GTEX-S33H-2326-SM-2XCB3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.961291 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QV44-0008-SM-447AX GTEx Tissue Sample Gene Expression Profiles 1.0 1.43485 GSE182680,GSE182683_0_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null abnormality of the cerebral vasculature GWASdb SNP-Phenotype Associations 1.0 0.257379 PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Avagacestat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168202 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null K562_Lenalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189502 outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.977208 K562_S3I-201_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145551 H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null wybutosine biosynthetic process GO Biological Process Annotations 2025 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.15754 GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37346 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null MCF7_UNC0379_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132391 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPZ ENCODE Transcription Factor Targets 1.0 null HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.16899 carbohydrate derivative binding GO Molecular Function Annotations 2015 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09339 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24634 SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-0005-SM-2XCED GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56354 GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58841 A549_Quisinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0279555 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59969 RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.969935 GSE239844_11_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null cervix uteri GTEx Tissue Gene Expression Profiles 1.0 1.58221 K562_Regorafenib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.024423 GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61359 ISL1-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null A549_SL-327_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016919 NRF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_INO-1001_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153103 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7IZ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-5304-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QLQW-0226-SM-447BJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.3587 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.828225 PMC12612227-41523_2025_836_MOESM1_ESM.pdf-32-ZNF585A_ZNF585A Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEG01 CCLE Cell Line Gene CNV Profiles -1.0 -1.80991 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-12T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.835142 Flavoprotein-like InterPro Predicted Protein Domain Annotations 1.0 null CLCN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32499 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 prostate gland epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null decreased hematocrit MGI Mouse Phenotype Associations 2023 1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.053695 BFTC-909 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6345 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.49236 CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null K562_M344_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0605664 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06498 hsa-miR-3622a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23715 principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02588 K562_Anacardic Acid_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156836 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KARPAS-299 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.79 K562_Meprednisone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0169475 PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30065 ZNF277 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02581 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.297168 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PBX3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE152441,GSE152442_6_v_2_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08261 EBF1 ENCODE Transcription Factor Targets 1.0 null organic cyclic compound binding GO Molecular Function Annotations 2015 1.0 null GTEX-RU1J-0008-SM-46MV9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08076 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-301b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE240386,GSE242143_1_v_5_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null CEBPB_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Crizotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0169471 PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4A-Supplemental_Table_S4A_Differentially_expressed_genes_upon_ZFX_Knock_down_in_C42B_ZFX Rummagene Transcription Factor Associations 2026 1.0 null TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXP1-21924763-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OE-01A-11R-A206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.930478 YY1_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null parkinson disease GAD Gene-Disease Associations 1.0 null HOXD12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0241 GTEX-QMRM-0926-SM-447BR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906716 GSE214382,GSE214383_3_v_2_ascl1_human RummaGEO Gene Perturbation Signatures 1.0 null CNN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37627 GSE186471_1_v_2_carnosol_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-W5X1-2626-SM-4LMI8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34587 primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.947262 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null heterocycle metabolic process GO Biological Process Annotations 2015 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Busulfan_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0205516 disease of metabolism GWASdb SNP-Disease Associations 1.0 0.183113 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 1.44387 GTEX-WFG8-2526-SM-3GILR GTEx Tissue Sample Gene Expression Profiles 1.0 1.15327 GTEX-RTLS-0326-SM-2TF6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.13795 MCF7_Maraviroc_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132716 K562_Belinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0493209 Kidney renal papillary cell carcinoma_KIRP_TCGA-UN-AAZ9-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tRNA modification GO Biological Process Annotations 2023 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null A549_Fasudil_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0152285 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.29105 ABRACL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31843 ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.3391 K562_Lapatinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0290083 PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null FOXA2 ENCODE Transcription Factor Targets 1.0 null GTEX-POMQ-2126-SM-2S1OJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.912933 ZNF512B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49784 A549_JQ1_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.011366 496100580_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.30717 NRF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8317-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null REST_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3 ENCODE Transcription Factor Targets 1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31057 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0504 GSE216273,GSE216292_14_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Ramelteon_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0171075 GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66519 JUN ENCODE Transcription Factor Targets 1.0 null inherited metabolic disorder GWASdb SNP-Disease Associations 1.0 0.320318 GSE174498,GSE174500_5_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null A549_Tucidinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172011 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17853 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09836 Sarcoma_SARC_TCGA-DX-A1L0-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Ofloxacin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0124252 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13443 MCF7_Aminoglutethimide_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150419 TNNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30064 WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.92238 IZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00288 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Valproic acid sodium salt_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0328197 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.425428 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_10_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null DCAF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21596 A549_Givinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0136606 GSE238018_3_v_2_mxra8_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.32998 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-A6W5-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A70Z-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29984 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE224294_4_v_2_ngly1_human RummaGEO Gene Perturbation Signatures 1.0 null A549_PF-573228_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016523 MCF7_Maraviroc_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132321 GTEX-OXRN-1726-SM-3NM9B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957019 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SORD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04278 GSE171177,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30313 GSE229973_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null TEAD4_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TP63 ChEA Transcription Factor Targets 1.0 null amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.928007 CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.65367 III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23072 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.843136 CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-1426-SM-4AD66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.846369 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.829322 A549_AZ 960_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0106457 GTEX-N7MT-0011-R6a-SM-2I3G3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12381 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Triamcinolone Acetonide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00840293 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UA-39-TN76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207952 K562_Costunolide_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0202236 Lung squamous cell carcinoma_LUSC_TCGA-70-6722-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277094 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14253 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90633 A549_S-Ruxolitinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150919 outer SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3475 decreased vertical activity IMPC Knockout Mouse Phenotypes 1.0 null RL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Motesanib Diphosphate_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.025121 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69069 amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13271 K562_PHA-680632_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0261479 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE115542_2_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KM-8442-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ESRRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0158 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R45C-0008-SM-48FF2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06649 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.3726 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE152441,GSE152442_0_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PX3G-2426-SM-48TZZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.97447 GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 0.85195 MCF7_SL-327_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139782 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.989431 A549_PHA-680632_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0106959 NR3C1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null IM-95 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16298 K562_Resminostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0905051 K562_AG-14361_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0227827 GSE119978,GSE180930_6_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Flavin Mononucleotide HMDB Metabolites of Enzymes 1.0 null abnormality of the vasculature GWASdb SNP-Phenotype Associations 1.0 0.091552 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NY-05A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05736 K562_Andarine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.019436 ERCC6L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41107 superior colliculus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.44441 GTEX-Q2AH-1626-SM-3GAF8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.826797 A549_PD98059_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0191594 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8224-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S32W-0126-SM-4AD61 GTEx Tissue Sample Gene Expression Profiles 1.0 0.868514 GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37317 catalytic activity GO Molecular Function Annotations 2015 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-369-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.871373 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 GTEX-POYW-0426-SM-2XCEV GTEx Tissue Sample Gene Expression Profiles 1.0 1.24906 GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965728 GTEX-RU72-1426-SM-46MUF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.929545 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.98502 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838496 PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S7-Table_S7_Top_500_differentially_modified_gene_bodies_between_MM_and_its_precursors_in_AA_patients_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DNAJC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14274 hsa-miR-1179 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.893951 GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 0.98852 GSE216273,GSE216292_0_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null ZBTB33_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.962373 MCF7_ENMD-2076_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151663 GTEX-PLZ6-1126-SM-3P5ZR GTEx Tissue Sample Gene Expression Profiles 1.0 0.924384 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null blood GTEx Tissue Gene Expression Profiles -1.0 -1.28006 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G2E3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61599 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXC9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.759 CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AD-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.09958 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NL4W-0011-R9a-SM-2I3G1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33666 impaired pupillary reflex MGI Mouse Phenotype Associations 2023 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null wybutosine metabolic process GO Biological Process Annotations 2023 1.0 null DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23339 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null fmn binding GO Molecular Function Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8276-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_KW-2449_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0250085 NIHOVCAR3 CCLE Cell Line Gene CNV Profiles -1.0 -1.36832 EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_SB431542_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0323571 ANAPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38922 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Triglycerides GWAS Catalog SNP-Phenotype Associations 1.0 0.522843 GSTO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79993 decreased exploration in new environment MGI Mouse Phenotype Associations 2023 1.0 null GSE158834_0_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_astrocyte of the cerebellum_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2812-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.03931 Kidney renal papillary cell carcinoma_KIRP_TCGA-O9-A75Z-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHF21B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13066 MFN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4073 GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles 1.0 0.99346 posteroventral (inferior) parietal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.826022 SRF ENCODE Transcription Factor Targets 1.0 null K562_AC480_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146879 SRF JASPAR Predicted Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A50M-01A-21R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114883_0_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_CUDC-907_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0293549 GSE119978,GSE180930_6_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Selisistat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146708 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null ESRRA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null GTF2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09187 hsa-miR-4773 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 BCL3 ENCODE Transcription Factor Targets 1.0 null increased mean corpuscular hemoglobin concentration IMPC Knockout Mouse Phenotypes 1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.2358 GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WI4N-1426-SM-3LK7H GTEx Tissue Sample Gene Expression Profiles 1.0 0.826569 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T2IS-1026-SM-32QP1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20555 GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.13736 A549_Mocetinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0278796 GSE119978,GSE180930_2_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RNOR-0826-SM-2TF5C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40206 GTEX-T2IS-0011-R2A-SM-32QPF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845477 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27396 KDM5A ENCODE Transcription Factor Targets 1.0 null FBXO27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07097 K562_Momelotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168275 SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Azacitidine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0129357 outer portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.920651 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.60586 K562_Iniparib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0230444 GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles 1.0 2.07792 GTEX-OHPL-2526-SM-3MJGT GTEx Tissue Sample Gene Expression Profiles 1.0 0.90176 K562_SNS-314 Mesylate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0431104 K562_Ellagic acid_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0203732 GTEX-WOFL-0126-SM-3MJG2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.900141 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02317 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS 683 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30035 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.864869 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Daphnetin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141035 PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_PHA-680632_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0115388 Brain Lower Grade Glioma_LGG_TCGA-RY-A845-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4UY-1326-SM-4AD4X GTEx Tissue Sample Gene Expression Profiles 1.0 1.584 MCF7_A-366_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.010721 THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 68.4905 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-7002-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null MCF7_Quercetin_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137929 GSE214382,GSE214383_6_v_2_ascl1_human RummaGEO Gene Perturbation Signatures 1.0 null SREBF1 JASPAR Predicted Transcription Factor Targets 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P78B-1926-SM-3P616 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02524 GTEX-XMK1-0008-SM-4GICF GTEx Tissue Sample Gene Expression Profiles 1.0 0.975389 GTEX-XUJ4-1926-SM-4BOOV GTEx Tissue Sample Gene Expression Profiles 1.0 0.901987 GTEX-S7SF-1326-SM-4AD4P GTEx Tissue Sample Gene Expression Profiles 1.0 1.0281 K562_WHI-P154_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168338 GSE201309_4_v_6_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTNNB1-20460455-HCT116-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ATF3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ6-0226-SM-3P61I GTEx Tissue Sample Gene Expression Profiles 1.0 0.907714 Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 GTEX-S33H-1126-SM-2XCB6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.941508 Lung GTEx Tissue Gene Expression Profiles 2023 1.0 1.20185 Amygdala TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 A549_S-Ruxolitinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0132321 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.835511 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.879006 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.351679 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RB-01A-12R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null synucleinopathy DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Resveratrol_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159303 parkinson's disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 GSE229973_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03209 coenzyme binding GO Molecular Function Annotations 2015 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151090_0_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03367 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04049 SKMEL28 CCLE Cell Line Gene CNV Profiles -1.0 -1.49753 MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QCQG-1226-SM-48U23 GTEx Tissue Sample Gene Expression Profiles 1.0 0.893062 K562_Carmofur_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0314289 Perturb_4935_KD_TP53_SRP067400 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.2154 GSE158834_2_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7387553-41467_2020_17477_MOESM4_ESM.xlsx-B_LPS-stimulated_myeloid_cells-Cis-eQTLs_in_LPS-stimulated_myeloid_cells_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.916945 GTEX-TML8-0926-SM-4DXSJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.3441 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878447 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.849874 Lung adenocarcinoma_LUAD_TCGA-44-6774-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.888685 GTEX-XUZC-0426-SM-4BOPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01017 GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06216 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Sorafenib Tosylate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159562 K562_Fasudil_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0149048 K562_Droxinostat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175451 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null THAP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Enzastaurin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0294737 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-01A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4747-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GTEX-X15G-1626-SM-3NMB3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.859511 GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles 1.0 2.34059 GTEX-OHPK-2626-SM-2HMK9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.831111 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7588-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0881 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_UNC0631_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0292776 U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2181 GSE103068_5_v_3_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176305_0_v_1_rotenone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-V1D1-1726-SM-4JBHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03705 K562_Prednisone_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0197866 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-7268-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RELA ENCODE Transcription Factor Targets 1.0 null GTEX-QLQ7-0526-SM-2I5G3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874243 CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Ofloxacin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161116 Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XRN2-22483619-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null Prostate gland epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7840-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28739 CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5768-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_UNC0379_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0199315 GTEX-QMRM-0626-SM-447BQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886831 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null A549_Mocetinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0104254 BCLAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26851 SIX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Avian pallium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.2785 GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.33145 HMBOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0246 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.70097 Panobinostat_HEC-1-A Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0132239 K562_Fluorouracil_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0204513 Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXA1_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-1526-SM-4AD6Z GTEx Tissue Sample Gene Expression Profiles 1.0 2.31042 A549_Cimetidine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0236576 REST_PFSK-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Aldolase-type TIM barrel InterPro Predicted Protein Domain Annotations 1.0 null PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16298 GTEX-XPT6-0226-SM-4B65L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975035 GTEX-RU72-0011-R5A-SM-2TF6U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883695 EB-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16298 IZ in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.94664 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_AG-14361_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0137259 MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5 ENCODE Transcription Factor Targets 1.0 null K562_Givinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0194442 MLXIPL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8147 Prostate adenocarcinoma_PRAD_TCGA-HC-7749-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2 ChEA Transcription Factor Targets 1.0 null cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.219745 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_MLN8054_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.020531 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr7_72718240_G_T_b38 GTEx eQTL 2025 1.0 2.92198 nucleic acid metabolic process GO Biological Process Annotations 2015 1.0 null K562_Aurora A Inhibitor I_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0273581 SNU626 CCLE Cell Line Gene CNV Profiles 1.0 1.5178 all GWASdb SNP-Phenotype Associations 1.0 0.042464 GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 0.824694 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CE-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31815 chr7_72748158_A_G_b38 GTEx eQTL 2025 1.0 2.23633 NETO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02181 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.81197 MCF7_MLN8054_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0169115 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DN-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OV56 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.836564 POU2F2 ENCODE Transcription Factor Targets 1.0 null K562_Pelitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0187492 lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.39089 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr7_72749773_C_CT_b38 GTEx eQTL 2025 1.0 2.0135 TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Resminostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168504 NR3C1 ENCODE Transcription Factor Targets 1.0 null K562_ABT-737_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137687 MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-626 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35769 GTEX-XV7Q-1426-SM-4BRWA GTEx Tissue Sample Gene Expression Profiles 1.0 0.931893 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.67909 K562_Disulfiram_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0443028 GSE239844_8_v_12_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8423-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Veliparib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165913 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24398 medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.98522 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr7_72737931_A_T_b38 GTEx eQTL 2025 1.0 1.28976 CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I4-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52386 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-0326-SM-48FD2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06318 K562_Clevudine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0243955 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68A-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_UNC0379_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0125341 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7090-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Trichostatin A_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0253348 WDR77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67203 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null oxidation-reduction process GO Biological Process Annotations 2015 1.0 null SRF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26005 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68B-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8413-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.8982 HCFC1 ENCODE Transcription Factor Targets 1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -3.32998 GTEX-R55E-0008-SM-48FCG GTEx Tissue Sample Gene Expression Profiles 1.0 0.984164 Lung adenocarcinoma_LUAD_TCGA-78-7143-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPI1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE201309_5_v_0_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5200-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Mercaptopurine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0129254 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A1L1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_PF-3845_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0165079 HCC2218 CCLE Cell Line Gene CNV Profiles -1.0 -1.68919 SRF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3592-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174701_5_v_3_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null A549_Regorafenib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0135563 avian pallium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829221 GTEX-S4P3-0008-SM-3NM8R GTEx Tissue Sample Gene Expression Profiles 1.0 0.91862 K562_Mocetinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0244084 CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.2042 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null lyase activity GO Molecular Function Annotations 2015 1.0 null K562_ENMD-2076_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176558 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP1-21924763-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MCF7_INO-1001_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0117287 C16orf86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4874 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null CTNNB1-20460455-HCT116-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-8261-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.73452 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1719 H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ARHGEF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17866 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62175 KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2501 neurodegenerative disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05837 hsa-miR-3664-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Sarcoma_SARC_TCGA-SG-A6Z4-01A-22R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP1R2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1479 GSE239844_1_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null chr7_72766017_C_T_b38 GTEx eQTL 2025 1.0 6.3966 K562_Navitoclax_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0278085 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924306 Panobinostat_SW480 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0249608 SP4 ENCODE Transcription Factor Targets 1.0 null rna metabolic process GO Biological Process Annotations 2015 1.0 null PTPRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8012 GTEX-NL4W-0011-R6a-SM-2I3GA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19537 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.56894 GTEX-S341-1526-SM-4AD6K GTEx Tissue Sample Gene Expression Profiles 1.0 0.981706 K562_A-366_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160701 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_PJ34_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0559431 GTEX-WEY5-2326-SM-3GIKK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917191 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MCF7_Motesanib Diphosphate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132253 Radical SAM InterPro Predicted Protein Domain Annotations 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Amisulpride_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155664 MAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6625 NRF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPK-2426-SM-3MJGH GTEx Tissue Sample Gene Expression Profiles 1.0 1.48499 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.204 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_7_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null FTC133 CCLE Cell Line Gene CNV Profiles 1.0 1.50776 USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Givinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0294901 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transition metal ion binding GO Molecular Function Annotations 2015 1.0 null 496100602_TCx_dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.33811 CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_S3I-201_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0234774 KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.871676 GSE74251_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-7107-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Prednisone_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0268249 outer SZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00908 GSE216273,GSE216292_14_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NL4W-0011-R11A-SM-2I3DW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868917 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.66224 K562_Crizotinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144257 sirolimus_homo sapiens_gpl2895_gse16944 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null prostate gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6407-01A-13R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5766-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EIF2B5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35258 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Pracinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00840925 GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null neurodegenerative disease GWASdb SNP-Disease Associations 1.0 0.371378 NRF1 ENCODE Transcription Factor Targets 1.0 null GTEX-PWOO-0008-SM-48TDU GTEx Tissue Sample Gene Expression Profiles 1.0 2.19716 MED12L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39875 GSE119978,GSE180930_3_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31929 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01451 GTEX-N7MT-0011-R8a-SM-2I5GU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28277 HOXA10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8833 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.412196 GSE228106_3_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WM-266-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13428 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-5787-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.83274 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CUX1 ENCODE Transcription Factor Targets 1.0 null K562_Navitoclax_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0192955 Cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MCF7_Quisinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0226173 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE103309_2_v_0_ube3a_human RummaGEO Gene Perturbation Signatures -1.0 null K562_JQ1_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0514632 SRF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03403 LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.239094 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4774-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14644 hsa-miR-4747-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Anaplastic large cell lymphoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.783 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.045808 K562_Motesanib Diphosphate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0302364 SMIM10L2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44475 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BFTC909 CCLE Cell Line Gene CNV Profiles -1.0 -1.37286 A549_Valproic acid sodium salt_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161154 RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03209 CEBPB ENCODE Transcription Factor Targets 1.0 null CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null YY1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.861484 PAX5_OE_GDS4978_548_human_L428-PAX5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-RWS6-1726-SM-47JXP GTEx Tissue Sample Gene Expression Profiles 1.0 1.39416 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7091-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_BRD4770_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.019842 H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TML8-2026-SM-32QOP GTEx Tissue Sample Gene Expression Profiles 1.0 1.41207 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null Basal ganglion TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 A549_Tucidinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180978 K562_MK-5108_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0270757 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.22665 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Maraviroc_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0332819 ELK1 ENCODE Transcription Factor Targets 1.0 null ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72079 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62252 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14402 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFYVE26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07028 primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.918148 GTEX-OXRP-0126-SM-3NB32 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04045 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.90733 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213410_2_v_3_calcitriol_human RummaGEO Drug Perturbation Signatures -1.0 null BCL11A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NOP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31246 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.969935 MCF7_Nintedanib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148038 MCF7_Cediranib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140381 MCF7_Ellagic acid_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152157 GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6908 TEAD4 ENCODE Transcription Factor Targets 1.0 null III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24986 K562_MK-0752_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180857 hsa-miR-548b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null TEAD4_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superior rostral gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00833 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE196117_1_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null iron-sulfur cluster binding GO Molecular Function Annotations 2015 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977305 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.98217 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.877852 PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KNS60 CCLE Cell Line Gene CNV Profiles 1.0 2.01785 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.54571 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PB-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXP1 ChEA Transcription Factor Targets 1.0 null HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.25822 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.62662 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3473 A549_Iniparib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184005 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878447 GTEX-RM2N-0126-SM-48FDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.07159 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X1-01A-12R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE140997_2_v_1_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25952 S-Adenosylmethionine HMDB Metabolites of Enzymes 1.0 null NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.90287 SRF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE213588_8_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-759 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A641-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB33_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null organonitrogen compound biosynthetic process GO Biological Process Annotations 2023 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-A474-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_PD98059_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209725 496100348_TCx_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19067 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5465-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null SLC39A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22304 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23339 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.56548 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_PF-3845_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153686 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TMZS-0008-SM-47JWM GTEx Tissue Sample Gene Expression Profiles 1.0 1.47741 CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ncrna metabolic process GO Biological Process Annotations 2015 1.0 null MCF7_Abexinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.01544 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles 1.0 1.89801 Lung squamous cell carcinoma_LUSC_TCGA-39-5019-01A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909736 Parkinson Disease DisGeNET Gene-Disease Associations 1.0 null GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.03504 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RD-01A-12R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null K562_SL-327_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0300206 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.60258 NUP188 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53222 STAT1 ENCODE Transcription Factor Targets 1.0 null MCF7_Navitoclax_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0122567 NICN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03486 Tirabrutinib_SW48 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.00852077 A549_Dacinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0108448 GSE163297_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4531 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21979 H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UTHO-0011-R5A-SM-3GIJD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62818 NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Interstitial matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.558 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05846 GTEX-UJMC-0326-SM-3GAE2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43298 Sarcoma_SARC_TCGA-DX-A8BV-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_AG-490_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0143067 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4873_KO_EZH2_SRP095403 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.63483 HOXB7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8291 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Selisistat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0325045 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63734 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14644 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5744-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195559_2_v_7_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-0326-SM-2I3F2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04506 Electron transfer flavoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.655 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OV90 CCLE Cell Line Gene CNV Profiles -1.0 -1.39612 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL11A ENCODE Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.02141 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.973849 FOSL2 ENCODE Transcription Factor Targets 1.0 null A549_AZ 960_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0178196 K562_Curcumin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0360185 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.087393 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Roxadustat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0197411 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 76.4876 USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null MCF7_PFI-1_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.022993 GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883431 GTEX-N7MT-0011-R5a-SM-2I3G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06248 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_5_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null A549_Quisinostat_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.024695 MCF7_CEP-33779_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156222 SNU410 CCLE Cell Line Gene CNV Profiles 1.0 1.33105 GTEX-T2IS-0008-SM-4DM75 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912087 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.67733 GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles 1.0 1.09487 OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60314 NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2501 CHD1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WVLH-0226-SM-3MJG6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.900643 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null ganglion TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6332-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Busulfan_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144335 CTCF_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.86074 EVSAT CCLE Cell Line Gene CNV Profiles 1.0 1.62048 E2F1-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.7955 GTEX-P4QT-2626-SM-2I3FM GTEx Tissue Sample Gene Expression Profiles 1.0 0.877636 GTEX-REY6-1726-SM-48FDL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931566 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4644-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_increase_in_MLL-AF4_ChIP-seq_signal_371_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_AT9283_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.023088 abnormality of central motor function GWASdb SNP-Phenotype Associations 1.0 1.12773 CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00372 POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5966 Acute Myeloid Leukemia_LAML_TCGA-AB-2848-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.57021 hsa-miR-548u TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Altretamine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0188093 GSE174701_4_v_7_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null FBXO10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32752 hippocampus (hippocampal formation)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.51414 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05072 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37962 TCF4 ChEA Transcription Factor Targets 1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202497 KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01149 K562_Droxinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.045127 K562_EED226_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171554 subgenual (subcallosal) division of MFC (area 25) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.839533 496100519_HIP_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.60275 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GP5D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.828578 K562_PFI-1_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177458 NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AH-0126-SM-48U2B GTEx Tissue Sample Gene Expression Profiles 1.0 1.02981 GSE118077_7_v_8_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.75195 SP2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tRNA wybutosine-synthesis InterPro Predicted Protein Domain Annotations 1.0 null tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_PFI-1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0125245 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RC-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-VUSH-0008-SM-47JWK GTEx Tissue Sample Gene Expression Profiles 1.0 1.21485 CHD1 ENCODE Transcription Factor Targets 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47797 E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.856541 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174498,GSE174500_2_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null SP2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-8179-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100555_TCx_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.48961 GSE213588_10_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Belinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0105367 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4PP-2426-SM-3P61L GTEx Tissue Sample Gene Expression Profiles 1.0 1.06895 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.95014 amygdala TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOXL2NB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05984 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EFO21 CCLE Cell Line Gene CNV Profiles -1.0 -1.90925 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102187_0_v_1_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S4UY-1226-SM-4AD51 GTEx Tissue Sample Gene Expression Profiles 1.0 0.907072 GTEX-QV31-0008-SM-447AT GTEx Tissue Sample Gene Expression Profiles 1.0 1.82572 GSE175787_11_v_2_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-5477-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50099 spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838719 EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-0008-SM-4DXUW GTEx Tissue Sample Gene Expression Profiles 1.0 1.45952 MCF7_AR-42_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0251001 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WR-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126463_6_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null MALME3M CCLE Cell Line Gene CNV Profiles 1.0 1.51219 KNS81 CCLE Cell Line Gene CNV Profiles 1.0 2.01947 EZH2 ENCODE Transcription Factor Targets 1.0 null A549_Obatoclax Mesylate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153808 A549_Panobinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0308118 GSE174498,GSE174500_2_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Trichostatin A_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0218522 decreased circulating alkaline phosphatase level MGI Mouse Phenotype Associations 2023 1.0 null GTEX-S32W-1226-SM-4AD67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.67165 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.93777 GTEX-WYBS-0926-SM-3NM94 GTEx Tissue Sample Gene Expression Profiles 1.0 0.951256 iron ion binding GO Molecular Function Annotations 2015 1.0 null POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19105 MCF7_Tofacitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177528 A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.67803 Lung adenocarcinoma_LUAD_TCGA-86-7713-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Quercetin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0298336 TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KANSL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46733 A549_Abexinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0370309 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-1126-SM-48TCF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925663 PAX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.5814 CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE140997_10_v_7_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23138 inner CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.926058 CC-68-YZ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220445 K562_Decitabine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137451 Lung squamous cell carcinoma_LUSC_TCGA-70-6723-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNRNPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31551 basolateral nucleus (basal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.903869 GTEX-P4QT-2426-SM-3NMCL GTEx Tissue Sample Gene Expression Profiles 1.0 2.85596 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21886 Flavodoxin InterPro Predicted Protein Domain Annotations 1.0 null ATF1 ENCODE Transcription Factor Targets 1.0 null GSE201309_4_v_2_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH322 CCLE Cell Line Gene CNV Profiles 1.0 1.92683 K562_Nintedanib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016611 GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles 1.0 3.13013 hsa-miR-130b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 A549_AR-42_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0394799 GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98748 GSE103068_0_v_7_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12870_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Maraviroc_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147777 TMEM134 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45181 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RTLS-2426-SM-46MUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.48458 ELK4_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-663b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.77322 ion binding GO Molecular Function Annotations 2015 1.0 null GSE239688_4_v_0_canagliflozin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC Rummagene Transcription Factor Associations 2026 1.0 null GSE245778_1_v_0_runx1_human RummaGEO Gene Perturbation Signatures -1.0 null SIX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHOX2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.2756 POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-595 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 A549_Altretamine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147871 PBX3 ENCODE Transcription Factor Targets 1.0 null GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0117 NUDT19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20843 GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950985 NNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28657 GTEX-RVPU-0011-R10A-SM-2XCAH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.969846 E2F4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZM-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null metal ion binding GO Molecular Function Annotations 2015 1.0 null cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null VASH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81614 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174701_1_v_0_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null HOXB9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.7836 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE192771_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE151612_4_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_SRT2104_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0230356 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GR-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chr7_72752126_C_T_b38 GTEx eQTL 2025 1.0 1.04391 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null SNRNP27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13558 CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNOS-0526-SM-4DM54 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41914 CCNT2 ENCODE Transcription Factor Targets 1.0 null GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960513 Rectum adenocarcinoma_READ_TCGA-DC-6682-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.76798 QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.25461 Lung adenocarcinoma_LUAD_TCGA-75-6211-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain - Caudate (basal ganglia) GTEx Tissue Gene Expression Profiles 2023 1.0 1.35619 MYBL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1105 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12776 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5X1-0426-SM-3GILB GTEx Tissue Sample Gene Expression Profiles 1.0 1.05394 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46621 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFYB ENCODE Transcription Factor Targets 1.0 null IZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13224 Gallic acid (hydrate)_C32 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0136759 Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75H-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null A549_Altretamine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145174 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null GTEX-OXRN-0011-R5A-SM-2I5EF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04525 HC-74-HM63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.287805 CTCF_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_SGI-1776 free base_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139483 GTEX-SNOS-0226-SM-32PLR GTEx Tissue Sample Gene Expression Profiles 1.0 1.02514 CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-5142-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TLCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04405 Uterine Carcinosarcoma_UCS_TCGA-NA-A4QX-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 4 iron, 4 sulfur cluster binding GO Molecular Function Annotations 2015 1.0 null mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.96382 nucleotide binding GO Molecular Function Annotations 2015 1.0 null Panobinostat_AsPC-1 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0242511 GTEX-P4PP-1726-SM-2S1NS GTEx Tissue Sample Gene Expression Profiles 1.0 0.839527 NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04996 chr7_72768844_C_T_b38 GTEx eQTL 2025 1.0 11.3978 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZC-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36788 K562_PJ34_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0175212 MCF7_Dacinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0226785 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metal cluster binding GO Molecular Function Annotations 2015 1.0 null BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1264 TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87466 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null 769-P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1029 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_2_CCF-Affected_Genes_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R3-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null decreased vertical activity MGI Mouse Phenotype Associations 2023 1.0 null GTEX-S7SE-0011-R4A-SM-2XCDB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981688 TAF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Anacardic Acid_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168605 GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35954 Prostate adenocarcinoma_PRAD_TCGA-EJ-7317-01A-31R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-MO-A47R-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null H3K9ac_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-11A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF4_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BFTC-909 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.88669 SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49901 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Vagina GTEx Tissue Gene Expression Profiles 2023 1.0 1.16069 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.911355 NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-0011-R5a-SM-33HBK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.048 EXOSC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90244 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.963107 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28 ENCODE Transcription Factor Targets 1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_10 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06012 hsa-miR-130a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 MAPK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38006 TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_RG108_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0206166 MAZ ENCODE Transcription Factor Targets 1.0 null K562_Amisulpride_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0514962 AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.323955 GTEX-Q2AG-0011-R5A-SM-2HMJH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1721 SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.92238 GSE103068_0_v_3_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null HCC4011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.925799 Lung squamous cell carcinoma_LUSC_TCGA-34-8454-11A-01R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Triglyceride levels x short total sleep time interaction (2df test) GWAS Catalog SNP-Phenotype Associations 2025 1.0 5.6 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GUSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42976 GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27974 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14644 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.080077 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RTLS-0226-SM-2TF5E GTEx Tissue Sample Gene Expression Profiles 1.0 0.940282 Acute Myeloid Leukemia_LAML_TCGA-AB-2928-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null LU99 CCLE Cell Line Gene CNV Profiles -1.0 -2.05938 PMC10800016-table_s5_20230913_ddad186.xlsx-FvsC_-_DUX4_I-Unnamed_1_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TML8-1226-SM-32QON GTEx Tissue Sample Gene Expression Profiles 1.0 0.957473 Lung adenocarcinoma_LUAD_TCGA-44-2659-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.32998 medial intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00636 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Parkinson Disease dbGAP Gene-Trait Associations 1.0 0.588957 NR1H4::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0343 peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66708 Lung adenocarcinoma_LUAD_TCGA-50-5932-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_4882_OE_BCL2L1_SRP131666 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.28259 Lung squamous cell carcinoma_LUSC_TCGA-85-8287-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1244 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-NL4W-0011-R5a-SM-2I3GD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19469 GTEX-SIU7-0426-SM-2XCDX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19656 Lung adenocarcinoma_LUAD_TCGA-50-7109-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles 1.0 1.24917 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -2.27508 central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47402 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Belinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0231264 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1255a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 A549_JQ1_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0174635 GTEX-P4PP-2526-SM-3P61P GTEx Tissue Sample Gene Expression Profiles 1.0 0.862609 DVL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52389 Flavodoxin/nitric oxide synthase InterPro Predicted Protein Domain Annotations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20B-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.928358 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.902014 stroke GWASdb SNP-Phenotype Associations 1.0 0.576886 abnormality of nervous system morphology GWASdb SNP-Phenotype Associations 1.0 0.072823 GTEX-TML8-1126-SM-4DXSS GTEx Tissue Sample Gene Expression Profiles 1.0 1.04491 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null CCDC17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0291 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8002-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35066 GTEX-QLQW-1426-SM-2S1QU GTEx Tissue Sample Gene Expression Profiles 1.0 1.4243 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SRF_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Resminostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0183333 A549_Dacinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.015244 MCF7_ENMD-2076 L-Tartaric acid_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159516 GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175787_5_v_9_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I7-06A-22R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-11A-02R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF354C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07432 Perturb_4878_OE_BCL2L1_SRP131666 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.50194 GTEX-P4QS-1326-SM-3NMCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.22871 GTEX-WWYW-1326-SM-3NB2S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.9944 SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16767 GTEX-X4XY-1726-SM-46MVO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04568 K562_Raltitrexed_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168805 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Gandotinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0173193 HOXD9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3676 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81R-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ8-0011-R8a-SM-2HMLG GTEx Tissue Sample Gene Expression Profiles 1.0 0.873573 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.876504 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF4A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.6005 inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00987 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13845 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5550-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_12_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null SLC11A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44258 GTEX-X261-0011-R6B-SM-4E3J8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86661 GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52929 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null A549_UNC0631_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0211413 A549_Sodium Phenylbutyrate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0240921 UKE-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.14481 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_AICAR_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177388 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14253 K562_MK-5108_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0366032 A549_TG101209_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0134288 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-X4XY-0008-SM-46MVL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02195 CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.952822 A549_CUDC-101_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0165162 Triglycerides GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 CTNNB1 ChEA Transcription Factor Targets 1.0 null K562_JQ1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0132691 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_PCI-34051_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157496 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral parabrachial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.61512 A549_Ki8751_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0130577 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP1A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02417 GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08079 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32124 NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Panobinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.038812 GSE119978,GSE180930_6_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-95-7043-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_12_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-7657-01A-31R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_AC480_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153081 GTEX-QV31-0726-SM-3GAEG GTEx Tissue Sample Gene Expression Profiles 1.0 0.953589 RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.4976 chr7_72799456_T_C_b38 GTEx eQTL 2025 1.0 1.45584 GTEX-N7MS-0326-SM-4E3K2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.862032 CCDC90B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07649 GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.21391 Panobinostat_MIA PaCa-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0348855 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF7 ENCODE Transcription Factor Targets 1.0 null GSE102505_5_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MCF7_Vandetanib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164304 MCF7_Cimetidine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0164857 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.882312 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27723 K562_NVP-BSK805 2HCl_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0135637 GTEX-NPJ7-0011-R6a-SM-2I3G7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18694 NR2F2 ENCODE Transcription Factor Targets 1.0 null VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.968818 CTCF ENCODE Transcription Factor Targets 1.0 null SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Givinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0278712 Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Specific developmental disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.025 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.837927 K562_Altretamine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0264279 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Sorafenib Tosylate_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171829 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08569 tRNA modification GO Biological Process Annotations 2025 1.0 null GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50026 GTEX-VUSG-1126-SM-4KKZQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863336 GSE174498,GSE174500_3_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906375 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QI-01A-11R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE209898,GSE209899_0_v_1_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular aromatic compound metabolic process GO Biological Process Annotations 2015 1.0 null MCF7_Resveratrol_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160964 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1248 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08146 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.33088 K562_Bisindolylmaleimide IX_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.026012 CA46 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37974 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1852 deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27806 K562_Curcumin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0245322 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M6-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TML8-0008-SM-4DXUI GTEx Tissue Sample Gene Expression Profiles 1.0 2.39175 K562_AG-14361_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170828 MZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17724 decreased hematocrit IMPC Knockout Mouse Phenotypes 1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.83441 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.907014 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.951097 frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.66039 CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IK-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Ofloxacin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0178753 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.08567 GSE214382,GSE214383_1_v_2_ascl1_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Encorafenib_HEC-1-A Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0161536 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFON-2126-SM-3LK7O GTEx Tissue Sample Gene Expression Profiles 1.0 0.973939 GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37101 PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null K562_Lomustine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0224015 MET_knockdown_254_GSE38343 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.844647 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-301a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 A549_Sorafenib Tosylate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0243732 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_12_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-0011-R7A-SM-2XCAB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08094 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_JNJ-7706621_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155905 GTEX-PVOW-0426-SM-2XCF8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93589 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-0426-SM-48TCC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886361 decreased exploration in new environment IMPC Knockout Mouse Phenotypes 1.0 null A549_Pelitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013642 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POM121 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32066 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35884 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PIGP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36757 hsa-miR-432 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00949 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R1-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00919 Attention deficit hyperactivity disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.025 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08272 Belinostat_MIA PaCa-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0227624 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDUFA13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18395 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03904 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1719 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null THAP1 ENCODE Transcription Factor Targets 1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36714 MCF7_Roxadustat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0128904 E2F1 JASPAR Predicted Transcription Factor Targets 1.0 null SKBR3 CCLE Cell Line Gene CNV Profiles 1.0 1.33163 K562_PF-573228_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0226584 GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16772 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03043 ventral posterior medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22923 chr7_72723022_A_G_b38 GTEx eQTL 2025 1.0 2.48142 MCF7_Filgotinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0127223 K562_BMS-536924_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0364446 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HINFP JASPAR Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-95-7944-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLF4_01_341 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.64019 IRF4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-2226-SM-3TW8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21877 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175787_8_v_2_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WYVS-1726-SM-3NMAY GTEx Tissue Sample Gene Expression Profiles 1.0 1.39762 GTEX-NPJ7-0008-SM-4E3JS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864899 GTEX-XPT6-0126-SM-4B65S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909659 PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Pirarubicin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172904 GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58752 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RC-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.5226 K562_PCI-34051_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.032046 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSN1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.915684 MCF7_2-Methoxyestradiol_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150045 GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8478 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE119978,GSE180930_3_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null anion binding GO Molecular Function Annotations 2015 1.0 null YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59298 FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Entacapone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0202769 YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_JNJ-26854165_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150995 OPM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.39541 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUMBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55531 GTEX-QDVN-0008-SM-48U2D GTEx Tissue Sample Gene Expression Profiles 1.0 1.88451 cation binding GO Molecular Function Annotations 2015 1.0 null GSE120612_7_v_1_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.936396 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MCF7_TG101209_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0220595 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.4398 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4617-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-0011-R4a-SM-2I3GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856063 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null ZNF562 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09459 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_GSK-LSD1 2HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0181508 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26381 GJD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23941 hsa-miR-186 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39341 midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20373 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_BMS-265246_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0114196 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49693 Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4103-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149035_1_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null A549_Motesanib Diphosphate_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0102941 BCLAF1 ENCODE Transcription Factor Targets 1.0 null GSE119978,GSE180930_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Altretamine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145597 cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-SNOS-1026-SM-4DM4Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.957221 CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-0126-SM-2TC68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0275 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.90991 TBC1D10A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23081 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_I-Unnamed_1_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13764 trna processing GO Biological Process Annotations 2015 1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE109140_0_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Divalproex Sodium_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0273605 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.917204 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34613 CDX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1159 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A2C5-01A-12R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58319 DDX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48703 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1751 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.92067 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adult lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.113 NFYA ENCODE Transcription Factor Targets 1.0 null GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04492 striatum_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.990095 K562_Tranylcypromine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0191498 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30221 K562_Selisistat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0186931 MCF7_Alisertib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0122669 GSE158834_12_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SP1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Entinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0141907 MIS12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05063 RBBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04573 GTEX-RN64-0008-SM-48FEZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.860648 POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04846 NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924306 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of brain morphology GWASdb SNP-Phenotype Associations 1.0 0.136344 K562_SRT1720 HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167211 motor nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953483 GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles 1.0 1.03508 HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2043 PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09836 GSE129811_5_v_0_niacin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 1.09506 CEBPB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE209898,GSE209899_0_v_1_flcn_human RummaGEO Gene Perturbation Signatures 1.0 null G-402 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.872404 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TEAD4_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04825 Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Cimetidine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161775 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null K562_Resveratrol_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0321908 ZNF324 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.6473 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04486 MCF7_BMS-265246_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0135403 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null caudal ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23425 PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CAL 27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.956856 GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.66813 GATA2-19941826-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null A549_Pracinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0334159 GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95749 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.939671 APLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.846 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8345-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4827-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Cimetidine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148899 hsa-miR-570 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-88-CF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.22355 hsa-miR-3149 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE178292_0_v_3_melphalan_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XUJ4-0008-SM-4BOQI GTEx Tissue Sample Gene Expression Profiles 1.0 1.70753 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles 1.0 2.70701 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31574 K562_Tanespimycin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.019673 GTEX-N7MS-0225-SM-4E3HO GTEx Tissue Sample Gene Expression Profiles 1.0 1.54235 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null heart GTEx Tissue Gene Expression Profiles -1.0 -0.946554 Bladder Urothelial Carcinoma_BLCA_TCGA-FT-A3EE-01A-11R-A206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7409-01A-31R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATF3 ENCODE Transcription Factor Targets 1.0 null MCF7_MLN8054_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.017684 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-Z4-A9VC-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140997_4_v_5_nsun6_human RummaGEO Gene Perturbation Signatures 1.0 null K562_Thiotepa_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0389258 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.30116 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE153443_1_v_2_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Momelotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149713 medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.55372 GSE195713_0_v_1_lapatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE216273,GSE216292_14_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Disulfiram_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0321749 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.0668 GSE82032_3_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null FC-20-EQ58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.247352 GTEX-XUJ4-1326-SM-4BOQ9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17511 K562_CUDC-101_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0533629 496100290_PCx_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.57111 DCTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43492 GSE233049_2_v_0_atf3_human RummaGEO Gene Perturbation Signatures 1.0 null NCIH810 CCLE Cell Line Gene CNV Profiles -1.0 -2.01771 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE152441,GSE152442_6_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE239844_7_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4D-Supplemental_Table_S4D_List_of_differentially_expressed_genes_upon_siZFX_with_promoters_bound_by_ZFX_in_C42B_ZFX Rummagene Transcription Factor Associations 2026 1.0 null NRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142588_2_v_0_cinobufagin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00359 K562_GSK J1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153909 HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN ChEA Transcription Factor Targets 2022 1.0 null K562_Mocetinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0274874 Lung squamous cell carcinoma_LUSC_TCGA-63-6202-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML ENCODE Transcription Factor Targets 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.06742 K562_BRD4770_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0324689 SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lipid metabolism disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.07 K562_Cediranib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142918 USF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-8454-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44N-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32582 K562_Bosutinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168635 CTCF_WI38_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Luminespib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0305978 BC-84-BQ58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20662 GTEX-VJWN-0726-SM-3GIJ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34506 Integument TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.98447 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4815-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30035 Autosomal dominant intellectual developmental disorder 44 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.573 Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3622b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE109140_2_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null GTEX-SNMC-0826-SM-4DM66 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24905 GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 0.987077 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16655 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-0011-R4B-SM-46MWL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857379 K562_Sirtinol_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0246814 GFUS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42817 STAT3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null basal ganglion TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.95324 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61736 Acute Myeloid Leukemia_LAML_TCGA-AB-2871-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6410-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.65634 GSE213588_10_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Trichostatin A_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0346873 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB26 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6306 Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A898-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P44H-0008-SM-48TDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.44552 A549_Lenalidomide_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144737 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1 JASPAR Predicted Transcription Factor Targets 1.0 null CTCF_GM12868_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84179 RAJI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.906854 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-5396-01A-02R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AF-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE182680,GSE182683_0_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4504 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 K562_Carmofur_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178114 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05072 A101D CCLE Cell Line Gene CNV Profiles -1.0 -1.93503 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Decitabine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189023 K562_PCI-34051_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.02206 CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null glycosyl compound biosynthetic process GO Biological Process Annotations 2025 1.0 null inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.833377 NFYA JASPAR Predicted Transcription Factor Targets 1.0 null GSE158834_2_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57558 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF184 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50585 CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_0_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.02866 hsa-miR-4745-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 K562_PJ34_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0417752 Regio parietalis capitis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.579 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100500_PCx_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.85526 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AB-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARNT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0223 TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219361 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4410-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2667 K562_Tanespimycin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0195143 A549_Motesanib Diphosphate_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0209904 FB-66-UU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.380895 MCF7_Aminoglutethimide_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014509 MOLP-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16044 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5247-01A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7372-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.204929 HTR3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05448 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3914 GTEX-OIZG-1126-SM-2HMIU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81732 A549_UNC1999_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0134882 GSE140997_4_v_6_nsun6_human RummaGEO Gene Perturbation Signatures 1.0 null limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hsa-miR-496 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.65233 vascular disease GWASdb SNP-Disease Associations 1.0 0.296862 hsa-miR-4529-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 K562_Tie2 kinase inhibitor_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167884 K562_SRT3025 HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0232235 K562_Fasudil_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0321159 TAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH2228 CCLE Cell Line Gene CNV Profiles -1.0 -1.58644 MCF7_Carmofur_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156298 GTEX-R55E-0826-SM-2TC5M GTEx Tissue Sample Gene Expression Profiles 1.0 1.56279 HCC1534 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01564 POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3 Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1017-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82615 MCF7_Lapatinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161044 A549_Entacapone_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0149105 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPRYD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07947 Lung adenocarcinoma_LUAD_TCGA-75-6207-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21111 PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2 Rummagene Transcription Factor Associations 2026 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.97058 forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MCF7_Cyclocytidine HCl_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163989 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45199 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NALM-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.910571 K562_Pracinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0913999 Lung adenocarcinoma_LUAD_TCGA-73-4662-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-1026-SM-4DXT1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07837 SP2 ENCODE Transcription Factor Targets 1.0 null GTEX-OHPN-0011-R1A-SM-2I5GB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93593 Adrenocortical carcinoma_ACC_TCGA-OR-A5JV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28278 NCI-H322M COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14955 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.28111 NANOG_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1143 CCLE Cell Line Gene CNV Profiles -1.0 -1.41679 GATA2-19941826-K562-human ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-549 TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 ESRRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.001 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-0226-SM-4IHLH GTEx Tissue Sample Gene Expression Profiles 1.0 1.52373 CTCF_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the immune system GWASdb SNP-Phenotype Associations 1.0 0.068933 JMSU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.32155 GSE229973_3_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954853 HOXC10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3534 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null XRN2-22483619-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null A549_Panobinostat_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0113268 amygdaloid complex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.852332 HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null SLC16A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0073 RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5509-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE218060_7_v_6_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null abnormality of immune serum protein physiology GWASdb SNP-Phenotype Associations 1.0 0.857878 primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.858074 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null SRF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null impaired pupillary reflex IMPC Knockout Mouse Phenotypes 1.0 null MCF7_Tanespimycin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179693 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47223 K562_Hesperadin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0123841 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4874_KO_SUZ12_SRP095403 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE172016_2_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null HOXC9 ChEA Transcription Factor Targets 1.0 null H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10795 inner CP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.88426 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null GTF3C2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE243879_1_v_0_elapor1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE163240_3_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6395-01A-13R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S341-1326-SM-4AD72 GTEx Tissue Sample Gene Expression Profiles 1.0 0.93042 H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1304 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 K562_Nilotinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0254071 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-656 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 0.951319 single-organism metabolic process GO Biological Process Annotations 2015 1.0 null AP-1 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24903 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7888-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P78B-2226-SM-3P5ZZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.01304 K562_Tazemetostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0233285 TAF1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF3C2 ENCODE Transcription Factor Targets 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPN-2726-SM-2I5H4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.838257 WRNIP1 ENCODE Transcription Factor Targets 1.0 null GTEX-P4QT-2026-SM-3NMCJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.959995 MCF7_Quercetin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0195049 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Tucidinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0425153 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36975 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04996 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100472_PCx_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.82666 IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.917204 MCF7_2-Methoxyestradiol_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0130124 POLR2A ENCODE Transcription Factor Targets 1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-0126-SM-2TC5Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.976338 K562_Clevudine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0256219 primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00961 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HT-1080 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24752 MYBL2 ENCODE Transcription Factor Targets 1.0 null GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14466 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -2.34516 CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174701_1_v_7_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6962-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04154 cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null ZBTB33 ENCODE Transcription Factor Targets 1.0 null HOXC11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.3039 MCF7_Sodium Phenylbutyrate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016606 GTEX-XPT6-0008-SM-4B64Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871332 K562_Zileuton_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177324 REST_PFSK-1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12554 PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE148200_0_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null THAP1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HY-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null K562_PJ34_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.024067 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3313-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4537 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26073 Cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29519 Sarcoma_SARC_TCGA-KD-A5QS-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SF3B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00261 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Bisindolylmaleimide IX_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.021366 K562_UNC1999_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0317283 HOXC12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.651 GTEX-VJWN-0126-SM-3GIK7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.953067 MCF7_S-Ruxolitinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176395 NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_BMS-265246_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0138104 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.3418 K562_Quisinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.103961 A549_Lomustine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0307865 GSE150134_1_v_0_fluorouracil_human RummaGEO Drug Perturbation Signatures 1.0 null JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_ABT-737_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0266001 MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.5216 YY1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Barasertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0279267 CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null brain disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 Sarcoma_SARC_TCGA-QC-A6FX-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DOHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34182 GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07491 GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF4-23295773-U87-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Fingolimod (hydrochloride)_SW48 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0195613 RIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43104 ASGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03447 morphological abnormality of the central nervous system GWASdb SNP-Phenotype Associations 1.0 0.082081 K562_Celecoxib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0286255 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPARD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.3629 Lung adenocarcinoma_LUAD_TCGA-50-6594-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70028 AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21528 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33704 hsa-miR-1238 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 artery disease GWASdb SNP-Disease Associations 1.0 0.365572 GTEX-S32W-1626-SM-4AD6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.91137 SALL4_01_98 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.01527 nucleoside phosphate binding GO Molecular Function Annotations 2015 1.0 null GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47712 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-0011-R6A-SM-2TF71 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0992 anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09278 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-2A-A8VT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Aminoglutethimide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0134987 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5517-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_AR-42_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0286634 K562_Amisulpride_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0214484 ERBB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4266 CTCF-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.59536 K562_JNJ-26854165_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0213757 A549_Dacinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0416842 TMEM88B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47395 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.17391 GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0001 GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01549 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6827-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Quisinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0204264 CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19565 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICR 10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.927908 TCF4-23295773-U87-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13199 Piriform area TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.079 GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles 1.0 0.911216 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U412-0008-SM-4DXTE GTEx Tissue Sample Gene Expression Profiles 1.0 2.77562 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCAI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1614 substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.913205 HIPK2_overexpression_28_GDS4233 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.60445 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1406 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 105KC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.86791 MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.900243 MCF7_JQ1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0230456 synucleinopathy GWASdb SNP-Disease Associations 1.0 1.28819 GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 1.14774 GTEX-OOBK-1026-SM-48TC2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14993 GSE182680,GSE182683_10_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.92238 K562_Nilotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0123187 GTEX-POMQ-1426-SM-3P61D GTEx Tissue Sample Gene Expression Profiles 1.0 1.47837 GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3 Rummagene Transcription Factor Associations 2026 1.0 null PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11D-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.52058 GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles 1.0 3.11987 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7045-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-96-7544-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4716-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 MESSA CCLE Cell Line Gene CNV Profiles -1.0 -1.32716 IRF3 ENCODE Transcription Factor Targets 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-2126-SM-447AE GTEx Tissue Sample Gene Expression Profiles 1.0 1.14993 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236502_1_v_3_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RU1J-0826-SM-46MUU GTEx Tissue Sample Gene Expression Profiles 1.0 1.60244 GSE151612_0_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Stroke dbGAP Gene-Trait Associations 1.0 0.618436 GSE103068_5_v_7_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10539177-41375_2023_2003_MOESM2_ESM.xlsx-CCF-Gene_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null MED19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95974 NALM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.57342 GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.66987 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128844_0_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE103068_5_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null MED4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45973 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE182680,GSE182683_10_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WXYG-2226-SM-4E3IM GTEx Tissue Sample Gene Expression Profiles 1.0 1.39022 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.917204 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPD_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVUS-0008-SM-447AY GTEx Tissue Sample Gene Expression Profiles 1.0 2.352 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14722 HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7473 K562_Mercaptopurine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0286024 Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE228106_3_v_4_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OAW28 CCLE Cell Line Gene CNV Profiles -1.0 -1.63608 HOXA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7086 FOXA1 ENCODE Transcription Factor Targets 1.0 null BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.38945 FGF21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23691 IRF1 ENCODE Transcription Factor Targets 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.6239 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214931_2_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Quisinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0357862 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71434 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A5U2-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWO3-0926-SM-2I5EY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01945 VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.833481 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.93616 SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_ZM 447439_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0246544 K562_ITSA-1_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172474 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14007 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17044 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-71-6725-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_S3I-201_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0194192 parkinsonism GWASdb SNP-Phenotype Associations 1.0 1.12773 CTCF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Aurora A Inhibitor I_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0125571 RCOR1 ENCODE Transcription Factor Targets 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null LARP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76634 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76524 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28616 mediodorsal nucleus of thalamus_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13319 lingual gyrus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.910715 Prostate adenocarcinoma_PRAD_TCGA-EJ-7317-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles 1.0 2.41707 GSE142210_3_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null TCF7L2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4176 K562_Alendronate sodium trihydrate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173031 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7006-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE218060_2_v_4_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Flavopiridol HCl_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162464 ACSM2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45914 GTEX-S4UY-1426-SM-4AD6Y GTEx Tissue Sample Gene Expression Profiles 1.0 2.20831 K562_KW-2449_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0217952 GSE94849_3_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null 496100627_TCx_no dementia_TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.22273 A549_RG108_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166148 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6433273-pone.0214296.s009.xlsx-Table_D-S4_Table_Differentially_expressed_mRNAs_in_human_primary_monocytes_after_24_hours_of_LPS_stimulation_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Belinostat_NCI-H661 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0212345 K562_2-Methoxyestradiol_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155702 Lung squamous cell carcinoma_LUSC_TCGA-56-7221-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_GSK-LSD1 2HCl_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015274 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02444 GSE245270_2_v_5_isoproterenol_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11673 OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.9887 PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3 Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFG7-0326-SM-3GILI GTEx Tissue Sample Gene Expression Profiles 1.0 0.851279 THOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11415 K562_AZ 960_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.022066 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1742 K562_Amisulpride_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0290857 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HUP-T4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.15602 Belinostat_BT-474 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0264525 Brain Lower Grade Glioma_LGG_TCGA-CS-5395-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140997_10_v_1_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null AM38 CCLE Cell Line Gene CNV Profiles -1.0 -2.79524 HMGN3 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A84S-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Resminostat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0235081 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null triglycerides GAD Gene-Disease Associations 1.0 null K562_Anacardic Acid_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0251769 GSE182680,GSE182683_0_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null K562_Glesatinib(MGCD265)_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158756 HCT116 CCLE Cell Line Gene CNV Profiles 1.0 1.96791 GTEX-X62O-0126-SM-4E3JN GTEx Tissue Sample Gene Expression Profiles 1.0 0.845301 K562_Roscovitine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0319416 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.39765 organic substance metabolic process GO Biological Process Annotations 2015 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMS11 CCLE Cell Line Gene CNV Profiles 1.0 1.96394 CL11 CCLE Cell Line Gene CNV Profiles 1.0 1.56251 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6997-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.849424 GATB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07402 CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4656 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GTEX-XQ3S-0008-SM-4GIDZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.24593 CTCF_epithelial cell of esophagus_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918529 PMPCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31162 K562_Tozasertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162238 4EGI-1_NCI-H2122 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.027893 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-6562-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null golgi apparatus LOCATE Predicted Protein Localization Annotations 1.0 null frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.831518 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0608 Lung squamous cell carcinoma_LUSC_TCGA-56-6545-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XO-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular metabolic process GO Biological Process Annotations 2015 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR1H2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 71.08 GSE239844_11_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NL3H-0011-R2a-SM-2I3GG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886403 MCF7_Panobinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157418 POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_TG101209_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0254312 GTEX-PX3G-2526-SM-48TZV GTEx Tissue Sample Gene Expression Profiles 1.0 1.14549 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06184 A549_Fedratinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139772 GTEX-PLZ6-1726-SM-2S1O6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00151 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4295 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32285 GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95805 GTEX-P4QR-0008-SM-48TE2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913137 ZC3H11A ENCODE Transcription Factor Targets 1.0 null K562_Glesatinib(MGCD265)_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0210325 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-POYW-0726-SM-2XCEO GTEx Tissue Sample Gene Expression Profiles 1.0 0.909129 H3K4me1_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AG-0011-R6A-SM-2HML7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872556 CSTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00083 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.902506 lipid metabolism disorder GWASdb SNP-Disease Associations 1.0 1.50906 nervous system disease GWASdb SNP-Disease Associations 1.0 0.078209 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.96986 A549_Dacinostat_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0133024 MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03209 RKN CCLE Cell Line Gene CNV Profiles -1.0 -2.69311 K562_SRT2104_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0313604 CTCF_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE119978,GSE180930_0_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null OLFML2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22633 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27151 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09241 PSME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07722 parolfactory gyri, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.884272 BEST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11014 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11861 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03432 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-0008-SM-4DXTQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.03328 Lung adenocarcinoma_LUAD_TCGA-05-4249-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Triglyceride levels x long total sleep time interaction (2df test) GWAS Catalog SNP-Phenotype Associations 2025 1.0 5.6699 GTEX-N7MS-2326-SM-2HMLD GTEx Tissue Sample Gene Expression Profiles 1.0 1.2488 GTEX-RNOR-0008-SM-48FEY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832771 SIX5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HMGXB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14776 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebrovascular disease GWASdb SNP-Disease Associations 1.0 0.673189 GSE128844_0_v_1_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -2.01983 HL-60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.58777 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null A549_Celecoxib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172206 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35169 BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.929503 GTEX-XUW1-0008-SM-4BOQH GTEx Tissue Sample Gene Expression Profiles 1.0 1.47313 NR3C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.2924 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35853 CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4512 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7825356-8844261.f3.docx-70-ZNF736_ZNF736 Rummagene Transcription Factor Associations 2026 1.0 null TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Panobinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0225067 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37878 GSE238018_3_v_0_mxra8_human RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-4942-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55493 K562_AZD1480_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0349857 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HOXD10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.3078 GTEX-RVPV-0011-R5A-SM-2TF69 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.973121 GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.9993 PAX5 ENCODE Transcription Factor Targets 1.0 null coronary artery disease GWASdb SNP-Disease Associations 1.0 1.50906 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles 1.0 1.34628 CAKI-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33946 PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TD-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSPB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34596 GTEX-RWS6-1926-SM-47JXY GTEx Tissue Sample Gene Expression Profiles 1.0 1.41764 hsa-miR-325 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30957 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.82097 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Cerdulatinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013291 SKOV3 CCLE Cell Line Gene CNV Profiles -1.0 -1.52125 GSE158834_2_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18006 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_ITSA-1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0290446 VZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.833676 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null abnormality of immune system physiology GWASdb SNP-Phenotype Associations 1.0 0.11651 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chr7_72738190_T_C_b38 GTEx eQTL 2025 1.0 3.10525 A549_Ofloxacin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167394 496100334_PCx_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.07008 K562_Alendronate sodium trihydrate_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164466 CBX3 ENCODE Transcription Factor Targets 1.0 null posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.973172 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A87E-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.94 Lung adenocarcinoma_LUAD_TCGA-95-7562-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Abexinostat_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0200927 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23293 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles 1.0 3.67109 K562_NVP-BSK805 2HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166916 MCF7_AMG-900_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164567 TAF7_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.867201 K562_Carmofur_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0199493 MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_M344_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.02483 K562_Veliparib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0258141 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74159 CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11535 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Tie2 kinase inhibitor_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016562 SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0179 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174498,GSE174500_5_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null GSE148200_3_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_AZD1480_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0141994 GTEX-TSE9-0011-R5A-SM-3DB7J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.999134 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DL-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_GSK-LSD1 2HCl_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155805 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07305 DPY30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48621 FOXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8036 central nervous system disease GWASdb SNP-Disease Associations 1.0 0.152707 GSE123861_1_v_0_sin3a_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4736 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61776 MCF7_Fedratinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0289757 HOXD12::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5206 A549_Pracinostat_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0106845 hsa-miR-3202 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GTEX-N7MS-0526-SM-4E3JP GTEx Tissue Sample Gene Expression Profiles 1.0 1.09048 GSE74251_2_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null ERF::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.2704 GTEX-WZTO-0011-R7B-SM-4E3IS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00029 K562_PFI-1_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0247088 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5281-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.843867 GTEX-POYW-0526-SM-2XCEY GTEx Tissue Sample Gene Expression Profiles 1.0 1.56532 GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16767 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32004 JUND ENCODE Transcription Factor Targets 1.0 null CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.445702 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22729 496100626_FWM_no dementia_TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.40157 Panobinostat_NCI-H1792 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0289372 GTEX-PX3G-2026-SM-48U1H GTEx Tissue Sample Gene Expression Profiles 1.0 0.836066 PRIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19199 decreased circulating serum albumin level IMPC Knockout Mouse Phenotypes 1.0 null SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.19769 GSE213588_8_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9222 Brain Lower Grade Glioma_LGG_TCGA-DU-7013-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9378 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.908144 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Momelotinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0134682 GTEX-Q734-0726-SM-48TZP GTEx Tissue Sample Gene Expression Profiles 1.0 1.03271 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4885-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Triglycerides Measurement DisGeNET Gene-Phenotype Associations 1.0 null GSE182680,GSE182683_0_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A5TY-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null Autism spectrum disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 IRF4 ENCODE Transcription Factor Targets 1.0 null GTEX-QDT8-0626-SM-48TYW GTEx Tissue Sample Gene Expression Profiles 1.0 1.54713 PMC7782476-41467_2020_20434_MOESM7_ESM.xlsx-KLF14_string_interactions-node1_KLF14 Rummagene Transcription Factor Associations 2026 1.0 null nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.91877 cofactor binding GO Molecular Function Annotations 2015 1.0 null GSE103068_5_v_8_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.964003 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RMDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2933 HDAC6 ENCODE Transcription Factor Targets 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_EED226_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173153 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4643-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TEAD4_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-58-A46J-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U3ZN-1426-SM-3DB87 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06068 pyramidal cells of rostral CA4 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.905461 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Panobinostat_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0162244 GSE153867_6_v_3_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null Autosomal dominant intellectual developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.292 CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RTLS-2326-SM-46MUH GTEx Tissue Sample Gene Expression Profiles 1.0 1.03513 corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.01972 anterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19661 PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11250262-41588_2024_1798_MOESM4_ESM.xlsx-ST18_665_top_menarche_genes-high_scorers_ST18 Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.73693 K562_Fulvestrant_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0246542 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-0826-SM-2XCBF GTEx Tissue Sample Gene Expression Profiles 1.0 0.874518 H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Panobinostat_SW48 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.018624 BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239688_2_v_5_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null ovary GTEx Tissue Gene Expression Profiles 1.0 0.970672 K562_Mesna_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0346967 JHOS4 CCLE Cell Line Gene CNV Profiles 1.0 1.60483 K562_2-Methoxyestradiol_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0273409 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_CUDC-907_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0192777 TCF12_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TSEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43647 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6591 K562_Lomustine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0362198 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52876 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14644 SYNDIG1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61782 SNU466 CCLE Cell Line Gene CNV Profiles 1.0 1.75662 MAX ENCODE Transcription Factor Targets 1.0 null RERF-LC-MS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31241 GTEX-WK11-0926-SM-3NMAU GTEx Tissue Sample Gene Expression Profiles 1.0 1.2519 DOK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15588 OC316 CCLE Cell Line Gene CNV Profiles 1.0 1.36725 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.44081 K562_AICAR_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0169876 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.3181 GTEX-R45C-0926-SM-3GAD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25641 GSE221327_1_v_2_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4Z8-0526-SM-4AD4T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962149 Prostate adenocarcinoma_PRAD_TCGA-CH-5737-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE229973_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37166 JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWO3-0011-R2A-SM-2S1OX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865584 wybutosine biosynthetic process GO Biological Process Annotations 2023 1.0 null CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null high-density lipoprotein particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.923 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_SRT1720 HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0310987 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.917204 K562_SRT3025 HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0366136 Lung squamous cell carcinoma_LUSC_TCGA-92-7340-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null iPS-18 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.88246 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89545 GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.983165 K562_Celecoxib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.027443 SRF_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null PDCD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36494 CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09413 hsa-miR-454 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 A549_PFI-1_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177406 GTEX-SUCS-0926-SM-4DM4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851971 Whole Blood GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.23672 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10X-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.859649 ACSS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02997 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4635-01A-02R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null GSE140997_4_v_3_nsun6_human RummaGEO Gene Perturbation Signatures 1.0 null primary auditory cortex (core)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12022 binding GO Molecular Function Annotations 2015 1.0 null NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09241 GSE235066_4_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-P4PQ-0326-SM-2HMJ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01771 BHLHE40 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7433 JUN JASPAR Predicted Transcription Factor Targets 1.0 null Perturb_4889_OE_BCL2L1_SRP131666 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.73473 rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.893041 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5454-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Triamcinolone Acetonide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180842 hsa-miR-574-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63307 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CO-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE163240_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Heart - Atrial Appendage GTEx Tissue Gene Expression Profiles 2023 1.0 1.61856 GTEX-V1D1-0626-SM-4JBHN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838561 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null K562_Tubastatin A HCl_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0195187 GTEX-RN64-0626-SM-2TC5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.0071 parkinson's disease GWASdb SNP-Disease Associations 1.0 1.28819 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BK-01B-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3 JASPAR Predicted Transcription Factor Targets 1.0 null GSE221327_4_v_9_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62684 K562_GSK1070916_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0418089 CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BAZ2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19351 Adrenal Gland GTEx Tissue Gene Expression Profiles 2023 1.0 3.66099 PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.32989 MCF7_Sirtinol_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0181075 Acute Myeloid Leukemia_LAML_TCGA-AB-2973-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPS20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.70311 GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles 1.0 0.851732 GSE178907_5_v_3_fkrp_human RummaGEO Gene Perturbation Signatures -1.0 null ZBTB33_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.846578 K562_Givinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0480917 GSE256181_1_v_0_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null FOXC2_01_236 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.63374 USF1 ENCODE Transcription Factor Targets 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null MAGOH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01958 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RNOR-0011-R7A-SM-2TF4V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15862 GTEX-W5X1-2326-SM-3GIL6 GTEx Tissue Sample Gene Expression Profiles 1.0 2.09201 RPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49712 A549_Tranylcypromine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176444 GSE161846,GSE161849_1_v_5_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -2.24834 CEBPB_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z2-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PEX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05169 GTEX-XQ8I-1926-SM-4BOOK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0906 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA3Z-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Furosemide_SW1417 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.00907085 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Mesothelioma_MESO_TCGA-LK-A4NW-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.29399 GTEX-WYBS-0626-SM-3NMAS GTEx Tissue Sample Gene Expression Profiles 1.0 1.14815 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOT4-0726-SM-4GIAW GTEx Tissue Sample Gene Expression Profiles 1.0 1.03187 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03752 K562_Dasatinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137723 hsa-miR-548l TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.953385 MCF7_Divalproex Sodium_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0212855 GTEX-S7SE-0011-R7A-SM-2XCDI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21139 H3K79me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEL4-0008-SM-447AZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.88806 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.25372 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34344 YY1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Alisertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0398252 E2F4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1339 CCLE Cell Line Gene CNV Profiles -1.0 -1.35871 GTEX-RWS6-2426-SM-2XCB9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.856322 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29577 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7283-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TML8-1626-SM-32QOO GTEx Tissue Sample Gene Expression Profiles 1.0 1.55843 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null frontal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.73161 MCF7_Quercetin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0117279 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18354 H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12258 CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833766 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.982936 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.864869 NOMO1 CCLE Cell Line Gene CNV Profiles 1.0 2.33206 GTEX-POMQ-2026-SM-2S1OD GTEx Tissue Sample Gene Expression Profiles 1.0 1.39003 GTEX-S4Z8-0008-SM-33HAZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954322 K562_Roxadustat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0210006 GSE182680,GSE182683_10_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null GTEX-QLQW-1226-SM-2S1Q9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08739 MCF7_JQ1_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147854 GTEX-R55E-0426-SM-2TC65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37267 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.16165 GSE178292_0_v_2_melphalan_human RummaGEO Drug Perturbation Signatures -1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BATF ENCODE Transcription Factor Targets 1.0 null GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31832 GTEX-P4PP-2026-SM-3P61N GTEx Tissue Sample Gene Expression Profiles 1.0 1.17304 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OCIM1 CCLE Cell Line Gene CNV Profiles 1.0 1.6497 H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41569 A549_JQ1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.01619 H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EI-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51831 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53125 HOXD11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3014 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null oxidoreductase activity GO Molecular Function Annotations 2015 1.0 null GTEX-P4QT-1826-SM-2S1NJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.19723 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 1.41455 NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 75.3561 H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6954-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARHGEF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86647 Forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NFIC_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X261-0011-R7A-SM-4E3JJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29176 GTEX-R55F-0126-SM-48FCK GTEx Tissue Sample Gene Expression Profiles 1.0 0.888758 GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles 1.0 1.26639 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.223969 HES2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9254 K562_Sodium Phenylbutyrate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0251778 A549_PF-3845_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0193331 MOTN1 CCLE Cell Line Gene CNV Profiles -1.0 -2.11865 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MN-0726-SM-32PML GTEx Tissue Sample Gene Expression Profiles 1.0 1.19721 CREB1 ENCODE Transcription Factor Targets 1.0 null GSE239844_6_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878447 GSE148657_2_v_0_cd44_human RummaGEO Gene Perturbation Signatures -1.0 null A549_BMS-536924_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157065 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.45924 GTEX-R55F-1426-SM-2TF53 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11851 RXRA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Alvespimycin_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.00961613 TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_9_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Tofacitinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0244555 PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE174701_5_v_8_maml3_human RummaGEO Gene Perturbation Signatures 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233647_2_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null A549_Aminoglutethimide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158738 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Ki16425_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151283 TFAP4::ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.8255 496100474_FWM_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21095 REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-01A-21R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211128_9_v_0_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Iniparib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0224587 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Baricitinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162103 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20H-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.54368 59M CCLE Cell Line Gene CNV Profiles -1.0 -1.46136 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_NVP-BSK805 2HCl_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015524 GSE182179_0_v_1_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WHPG-0826-SM-3NMBF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11001 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06715 K562_Temsirolimus_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0312636 SKIDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08218 HCC2279 CCLE Cell Line Gene CNV Profiles -1.0 -1.7063 SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3061 K562_NVP-BSK805 2HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0229531 fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01831 Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE228106_3_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null KMM1 CCLE Cell Line Gene CNV Profiles -1.0 -2.32532 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Waist circumference GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.552288 Lung adenocarcinoma_LUAD_TCGA-49-4490-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Dacinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.051262 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43649 hsa-miR-3666 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 MCF7_AZD1480_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0104053 JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SUP-M2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.604 GTEX-WK11-2726-SM-3NMAQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.842059 GSE175787_4_v_2_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-0011-R9A-SM-2TC6C GTEx Tissue Sample Gene Expression Profiles 1.0 0.829131 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.956739 K562_Flavopiridol HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0188176 MCF7_MC1568_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175474 K562_SNS-314 Mesylate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176307 K562_Danusertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0234452 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.52099 A549_JQ1_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0124837 HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21171 A549_Gandotinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179397 GTEX-WFG8-0008-SM-4LVN6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.87209 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4712-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03836 DUX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.5869 MCF7_Avagacestat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.019429 ZDHHC19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28886 ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Tanespimycin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177997 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.54474 GTEX-W5WG-1726-SM-4LMI5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24077 central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04097 GSE151612_0_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null TEAD4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pervasive developmental disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.711 USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XK-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Baricitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0181326 MCF7_ENMD-2076 L-Tartaric acid_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0175976 POLR3K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29345 PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39575 SRF_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Belinostat_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0113159 Lung adenocarcinoma_LUAD_TCGA-73-4675-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGFBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14373 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2136 MCF7_Fulvestrant_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0174468 MCF7_Lenalidomide_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156648 SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_0_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30191 A549_Lenalidomide_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0133264 heterocyclic compound binding GO Molecular Function Annotations 2015 1.0 null NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09241 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01564 K562_Obatoclax Mesylate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149797 SP2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-0126-SM-4BOOQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.3486 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A497-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUDHL6 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S32W-2526-SM-2XCB8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37246 GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_M344_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0202179 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.55678 locus ceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09659 ATF2 ENCODE Transcription Factor Targets 1.0 null PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53 Rummagene Transcription Factor Associations 2026 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null A549_Abexinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152876 H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Panobinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0266616 SP1 ENCODE Transcription Factor Targets 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null GSE171175,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Pracinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0235746 AP1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04226 primary auditory cortex (core)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3323 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7045-01A-31R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Ramelteon_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162297 K562_Busulfan_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0192273 Rectum adenocarcinoma_READ_TCGA-AG-3732-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IV-01A-22R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEATR5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27346 K562_Ramelteon_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0202544 posteroventral (inferior) parietal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14563 Prostate adenocarcinoma_PRAD_TCGA-CH-5768-11A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null decreased circulating alkaline phosphatase level IMPC Knockout Mouse Phenotypes 1.0 null GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 0.891773 abnormality of lipid metabolism GWASdb SNP-Phenotype Associations 1.0 1.35521 CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_AMG-900_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0309155 OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.44521 H3255 COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 K562_Roxadustat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0287883 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WWYW-3026-SM-3NB36 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977844 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32207 SW 48 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27556 A549_Ellagic acid_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0150227 GTEX-S7SF-0226-SM-3K2BI GTEx Tissue Sample Gene Expression Profiles 1.0 1.32157 KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16767 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4857-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XMK1-0626-SM-4B65A GTEx Tissue Sample Gene Expression Profiles 1.0 0.900605 HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9185 frontal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.63086 cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.884232 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.915684 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0504 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 PHACTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15293 CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-4459 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GTEX-PX3G-2626-SM-2I3EG GTEx Tissue Sample Gene Expression Profiles 1.0 0.934297 GTEX-R55F-1726-SM-2TF4R GTEx Tissue Sample Gene Expression Profiles 1.0 1.50026 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null trna metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11866 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2755-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Pelitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0256297 GTEX-PSDG-0626-SM-2S1OE GTEx Tissue Sample Gene Expression Profiles 1.0 0.836564 MCF7_Dacinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0195006 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJHI-1326-SM-4IHJO GTEx Tissue Sample Gene Expression Profiles 1.0 1.25803 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25759 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A118-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZSCAN16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2157 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Panobinostat_SW 900 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0186536 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferior rostral gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27666 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST ENCODE Transcription Factor Targets 1.0 null K562_Entinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161792 GTEX-QEG4-0008-SM-48TYZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.18424 SRF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15575 Mathematical Ability DisGeNET Gene-Phenotype Associations 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Triglycerides dbGAP Gene-Trait Associations 1.0 0.862644 A549_Sirtinol_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153852 MCF7_Quisinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0251046 TRIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2494 GSE216273,GSE216292_14_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_INO-1001_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179045 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42C-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_JQ1_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0132805 wybutosine metabolic process GO Biological Process Annotations 2025 1.0 null GSE187006_3_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.67574 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7473-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M5-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC JASPAR Predicted Transcription Factor Targets 1.0 null hsa-miR-1538 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GSE213588_9_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Panobinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0244826 K562_Ki8751_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0189538 A549_IOX2_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014641 A549_Lapatinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145842 GTEX-NL4W-0011-R2a-SM-2I5GV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14745 GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1466 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XV7Q-0226-SM-4BRVL GTEx Tissue Sample Gene Expression Profiles 1.0 0.971228 inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.36149 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 JHH2 CCLE Cell Line Gene CNV Profiles 1.0 1.3852 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BATF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186647,GSE217287_1_v_3_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8096-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Roxadustat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0219809 GTEX-T5JC-0008-SM-4DM6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.96538 GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12724 hsa-miR-4454 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 K562_S3I-201_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0202427 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.879176 hsa-miR-503 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3725-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MCF7_M344_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013985 K562_EED226_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0326744 K562_Entinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.042698 MEF2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6871 MTHFD1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02819 K562_Andarine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160945 CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.894121 HCC38 CCLE Cell Line Gene CNV Profiles 1.0 1.39263 GTEX-UJMC-0008-SM-4IHKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.09485 FOXM1 ENCODE Transcription Factor Targets 1.0 null SU-DHL-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30526 GTEX-RWS6-1326-SM-47JXB GTEx Tissue Sample Gene Expression Profiles 1.0 0.961452 GTEX-UJMC-0726-SM-3GADX GTEx Tissue Sample Gene Expression Profiles 1.0 0.867391 hsa-miR-4670-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GTPBP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21053 GTEX-QVJO-0008-SM-447AU GTEx Tissue Sample Gene Expression Profiles 1.0 1.85647 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80683 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Resminostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013319 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SB-01A-31R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_MLN8054_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0339031 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Panobinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0492339 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of extrapyramidal motor function GWASdb SNP-Phenotype Associations 1.0 1.12773 GTEX-P4QR-0426-SM-2S1NV GTEx Tissue Sample Gene Expression Profiles 1.0 0.960646 MCF7_PFI-1_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0217068 K562_G007-LK_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.045095 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.847285 MCF7_Temsirolimus_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0130863 SNU5 CCLE Cell Line Gene CNV Profiles 1.0 1.33309 GTEX-WFON-0126-SM-4LVM9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.85727 GTEX-P4QT-1326-SM-3NMD3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.68008 H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-0326-SM-2TF5T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972316 SP2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSKIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36269 ASAP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.701 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_UNC1999_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0330203 CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DOHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16298 superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.87286 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214931_3_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-455-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 SPI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_GSK J1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0149628 K562_SNS-314 Mesylate_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0320895 GTEX-T2YK-0326-SM-4DM7D GTEx Tissue Sample Gene Expression Profiles 1.0 0.927137 CEBPD_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr7_72768704_A_G_b38 GTEx eQTL 2025 1.0 2.19662 GTEX-S341-1126-SM-4AD6T GTEx Tissue Sample Gene Expression Profiles 1.0 1.53733 Temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 496100347_PCx_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0089 K562_MC1568_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0290343 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Clevudine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0205617 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.79232 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Temsirolimus_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0136212 H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6936-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Tobacco Use Disorder HuGE Navigator Gene-Phenotype Associations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PG-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null