association	dataset	threshold value	standardized value
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28262
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsal spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.32403
BRD-K40001806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6642
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46321
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.064334
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.42193
HS729	CCLE Cell Line Gene Mutation Profiles	1.0	null
CAPAN1	CCLE Cell Line Gene CNV Profiles	1.0	1.98522
GSE81803,GSE81912_3_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.924812
Lung squamous cell carcinoma_LUSC_TCGA-43-7657-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
substance dependence	GWASdb SNP-Disease Associations	1.0	0.783797
BRD-K76588804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07964
GSE239844_4_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO-205	GDSC Cell Line Gene Expression Profiles	-1.0	-1.62237
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109772
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A905-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1942_KO_Nelfb_SRP132312	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.85076
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cholecystolithiasis	GWASdb SNP-Disease Associations	1.0	0.581931
Perturb_9111_OE_FOXO1A3_SRP188991	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.58739
MCF7_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136013
IRF1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8OX-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03313
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20281
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07423
ZNF595	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89161
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.981627
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.5781
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914835
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5402-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.73979
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-1126-SM-4BOO2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916185
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137122
GTEX-NPJ8-0011-R7a-SM-2HMJV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977289
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843682
Perturb_6559_KO_Rabl2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03557
intermediate stratum of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20694
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4148
r9 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15792
KYSE410	CCLE Cell Line Gene Mutation Profiles	1.0	null
Systolic Blood Pressure Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40039
abnormal corpus callosum morphology	MPO Gene-Phenotype Associations	1.0	null
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal diencephalon morphology	MPO Gene-Phenotype Associations	1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CESS	GDSC Cell Line Gene Expression Profiles	-1.0	-2.06051
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74034
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26623
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-7944-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hyperactive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23439
FOXA2	ChEA Transcription Factor Targets	1.0	null
NB10	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46737
phosphotransferase activity, alcohol group as acceptor	GO Molecular Function Annotations 2015	1.0	null
U-698-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-1626-SM-3K2AE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05951
BRD-A89038047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8627
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28667
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.839865
Perturb_13080_KO_Cry2_SRP091906	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.11473
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12075
A549_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178729
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041704
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06354
myopathy	GWASdb SNP-Disease Associations	1.0	0.233497
SMAD3	ChEA Transcription Factor Targets	1.0	null
regulation of cell development	GO Biological Process Annotations 2015	1.0	null
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Lenalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149191
GTEX-TSE9-2526-SM-4DXUS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03965
LS-1034	GDSC Cell Line Gene Expression Profiles	-1.0	-1.80301
Perturb_5819_KD_Pcbp1_SRP324137	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.97742
GSE100316_5_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.80078
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AW-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lung disease	GWASdb SNP-Disease Associations	1.0	0.255528
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4805_KO_Mapk1_ERP004375	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.5787
SNUC1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00401
SC-48849 (BRE)	NURSA Protein Complexes	1.0	null
CL11	DepMap CRISPR Gene Dependency	1.0	16.5346
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-7493-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25829
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23084
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157391
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
WHAMM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39329
Median preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53725
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal cerebrum morphology	MPO Gene-Phenotype Associations	1.0	null
Anemia	CTD Gene-Disease Associations	1.0	1.11741
Infertility, Female	CTD Gene-Disease Associations	1.0	1.06297
POGLUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43341
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19166
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9335
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.864422
GTEX-S4Q7-1126-SM-4AD6R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861685
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06391
Perturb_7989_KO_Dnmt3a_ERP107953	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.925057
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09686
hydrocephalus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.701124
BRD-K90231936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19679
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_9127_OE_YAP_SRP090747	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.69039
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.95105
Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68300789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50016
BRD-K02927989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23666
Radial spoke head	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.371
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2273
GTEX-T6MO-1026-SM-4DM72	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883122
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994384
periventricular stratum of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11625
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013484
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.971339
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.70788
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873612
GTEX-X585-1026-SM-46MW6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864622
abnormal brain commissure morphology	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8339-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8883
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6109
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21813
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Protein kinase domain	InterPro Predicted Protein Domain Annotations	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.952942
Radial spoke	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
YWHAQ	Pathway Commons Protein-Protein Interactions	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
colon	HPA Tissue Protein Expression Profiles	1.0	0.710832
A549_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195666
SIX5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of MAPK cascade	GO Biological Process Annotations 2025	1.0	null
BRD-K52218664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21829
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IGROV1	CCLE Cell Line Gene Mutation Profiles	1.0	null
Perturb_1805_KO_Myd88_SRP377807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.0
CREB1	ENCODE Transcription Factor Targets	1.0	null
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12597
Lung squamous cell carcinoma_LUSC_TCGA-90-7766-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1_G1E-ER4_mm9_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
principal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1061
Acute Myeloid Leukemia_LAML_TCGA-AB-2839-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26057
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9399
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285737
abnormal head shape	MPO Gene-Phenotype Associations	1.0	null
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933517
PMC7893038-41598_2021_83450_MOESM3_ESM.xlsx-DBP_Baseline_TRANS-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34673
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.915823
cilium movement	GO Biological Process Annotations 2015	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.13268
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74988
JUND-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.50982
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137112
VDR-21846776-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POFUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71205
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100336_TCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05155
TIMM44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20623
Perturb_13845_KO_Lncpim1_SRP399839	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.29607
TTF2-22483619-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2709-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15024_OE_Atf3_SRP335029	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.58498
chr3_41927402_T_G_b38	GTEx eQTL 2025	1.0	7.09428
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.46292
A549_MC1568_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014938
A549_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01675
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14242
Perturb_13146_Mut_Atrx_SRP194170	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.40433
A549_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121271
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29704
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.895691
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890129
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40661
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paraventricular nucleus, cap part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45146
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.5087
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46133
A549_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169478
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13219_KO_Morc2a_SRP127601	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.4548
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.17202
AN3-CA	GDSC Cell Line Gene Expression Profiles	1.0	2.00141
JHU-022	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1650	GDSC Cell Line Gene Expression Profiles	-1.0	-3.01186
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.945438
NCI-H510A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-140-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
MITF	ChEA Transcription Factor Targets	1.0	null
MHH-PREB-1	GDSC Cell Line Gene Expression Profiles	1.0	1.62871
GTEX-OHPK-2326-SM-3MJH2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18041
YD38	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62627
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11063
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Renal proximal tubule	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00741
WDR20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11898
NCIH510	CCLE Cell Line Gene Mutation Profiles	1.0	null
Phagophore assembly site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.221
SOX3-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.147049
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5349
KAT2A	ENCODE Transcription Factor Targets	1.0	null
GUCA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09858
EP300_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RL-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9314667-Table_1.xlsx-Regulons-IRF4_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20948
alcohol dependence	GWASdb SNP-Disease Associations	1.0	1.09462
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25327
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52605
Lung adenocarcinoma_LUAD_TCGA-38-4626-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KG1	CCLE Cell Line Gene Expression Profiles	1.0	2.09304
CCF-STTG1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42902
J-RT3-T3-5	GDSC Cell Line Gene Expression Profiles	1.0	2.25601
HCC1419	CCLE Cell Line Gene Mutation Profiles	1.0	null
ELF5-23300383-T47D-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.65064
Brain Lower Grade Glioma_LGG_TCGA-DU-7007-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01036
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900371
smooth muscle	HPA Tissue Protein Expression Profiles	1.0	0.710832
Lung squamous cell carcinoma_LUSC_TCGA-22-5471-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11854_KO_Fosl2_SRP131329	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.18063
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52468
Acute Myeloid Leukemia_LAML_TCGA-AB-2928-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PANX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13621
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832628
cerebellar cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.83232
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936322
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR3C1	ChEA Transcription Factor Targets	1.0	null
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45998
Perturb_16651_KD_Fus_SRP179634	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.23819
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2179
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NC-76-YX69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249998
Atg1/ULK1 kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.393
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDE7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17329
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.991626
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.22774
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.3557
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
PMC5474565-onc2016488x2.xlsx-Table_S6_MA9_Enhancers_-_Genes-Genes_Closest_to_MLL-AF9_enhancers_within_the_same_TAD_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07932
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Blood protein disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.421
Aortic root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.168
MCF7_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160526
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5177
K562_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175616
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13596
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.886747
BRD-K39548949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06588
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.984941
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Perturb_14947_KD_Parp1_SRP102079	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.21027
Perturb_15677_KD_Srsf2_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.6955
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31729
SNU869	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83604
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDFI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84645
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_7084_KO_Perk_SRP309948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.995
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.889357
cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.58494
BRD-K99022424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58005
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.689
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Red blood cell count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.00458
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966774
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of cell projection organization	GO Biological Process Annotations 2015	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE233679_6_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UJHI-1326-SM-4IHJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28342
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9753996-jci-132-160767-s182.xlsx-IRF4_assciated-ABCA7_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.830594
regulation of neuron migration	GO Biological Process Annotations 2023	1.0	null
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.46503
BRD-K27294633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03881
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
regulation of neuron projection development	GO Biological Process Annotations 2023	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120612_6_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the skeletal system	GWASdb SNP-Phenotype Associations	1.0	0.056785
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE139966_5_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7155-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
multiple myeloma	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
ELK1	ChEA Transcription Factor Targets	1.0	null
BRD-K98535708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00386
SLC43A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28503
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145175
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.857943
K562_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140169
BRD-K75984692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23115
essential hypertension	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.58494
ulk	GeneRIF Biological Term Annotations	1.0	null
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6286
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67576
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
A549_SRT2104_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129399
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12873970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09413
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX8	ENCODE Transcription Factor Targets	1.0	null
PPP1R8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24474
BRD-K14534138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08284
BRD-K92374432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15229
GTEX-S32W-1426-SM-4AD66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13343
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.2092
A549_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144903
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876527
Perturb_10962_KO_Arl10_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.43378
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X88G-0326-SM-47JZ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01623
mantle zone of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18787
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6849-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phenothrin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04787
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.859753
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
parvicellular interstitial nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.00223
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.906266
MCF7_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00886037
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5794-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114232_10_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013492
MCF7_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155672
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.66865
K562_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0333069
asthma	GWASdb SNP-Phenotype Associations	1.0	0.834343
SNU1040	CCLE Cell Line Gene Mutation Profiles	1.0	null
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3456-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Mewo	GDSC Cell Line Gene Expression Profiles	1.0	1.42501
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07796
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
BRD-K95470847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36799
hearing/vestibular/ear phenotype	MPO Gene-Phenotype Associations	1.0	null
GATA1-19941827-MEL86-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.86024
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88381
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.98453
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPIC-1426-SM-4IHLQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.203
brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.131934
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194268
FAM86C2P	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33069
immunologic hypersensitivity	GWASdb SNP-Phenotype Associations	1.0	0.322127
HEC108	CCLE Cell Line Gene Expression Profiles	1.0	1.36146
Spev	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.437
ITK_defectivemutant_125_GSE28200	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.69183
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.04565
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
SMURF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K84936524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55088
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189825
JUN	ENCODE Transcription Factor Targets	1.0	null
MCF7_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179267
GTEX-WOFL-0726-SM-3MJG4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991913
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859238
SMC3	ENCODE Transcription Factor Targets	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201042_2_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1_G1E-ER4_mm9_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.867025
PMC9170821-JCMM-26-3183-s001.xlsx-Mic_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4985_KO_Ythdc1_SRP212677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.08929
ERG-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95619
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
chr3_41943282_TG_T_b38	GTEx eQTL 2025	1.0	2.85892
PMC12443547-DataSheet5.pdf-3-WT1_1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
anterior paraventricular nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02385
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.869203
Perturb_3099_KO_Mcam_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.9907
MCF7_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166838
LTC4S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02601
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27022
Perturb_4446_KD_Fbl_DRP007972	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.73633
chr3_41877500_T_C_b38	GTEx eQTL 2025	1.0	3.58509
NCI-H727	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37858
GSE145639_1_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.46025
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.964551
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
AZ521	CCLE Cell Line Gene Expression Profiles	1.0	1.47699
Diastolic blood pressure x alcohol consumption interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.12218
Necrosis	CTD Gene-Disease Associations	1.0	1.17629
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rutin (trihydrate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0124004
SNU520	CCLE Cell Line Gene Mutation Profiles	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2569
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.854399
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17762
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981906
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_11917_KO_Apoe_SRP135284	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.56878
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A76B-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.001
Sarcoma_SARC_TCGA-QQ-A5VB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Orbital area, medial part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21613
Perturb_12012_KO_B2_Mm2_SRP374407	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.38559
Perturb_12627_KO_Bag6_ERP110252	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.9485
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43746
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.882966
regulation of cell migration	GO Biological Process Annotations 2015	1.0	null
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220612
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_16853_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.31755
Oral apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01024
Lung squamous cell carcinoma_LUSC_TCGA-22-4596-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.963
MCF7_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140876
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart disease	GWASdb SNP-Disease Associations	1.0	0.904255
Flagellum attachment zone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.082
K562_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129907
obesity	GWASdb SNP-Disease Associations	1.0	0.693724
GSE214382,GSE214383_5_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2131
hsa-miR-3688-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
MCF7_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111176
Insulin	dbGAP Gene-Trait Associations	1.0	0.653108
Perturb_8371_KO_Myc/Mlxipl_SRP148418	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.9674
GSE182179_2_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
transverse gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.953988
BRD-K73524144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09051
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
intraventricular hemorrhage	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K93374700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23411
Adrenocortical carcinoma_ACC_TCGA-OR-A5K0-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.897351
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.94555
Lateral septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38041
gallbladder disease	GWASdb SNP-Disease Associations	1.0	0.417751
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5496
postnatal lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64449
K562_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227766
Perturb_16696_KO_31O21Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.2282
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.01663
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874297
GSE148252_0_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33209
MCF7_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136791
rare	GeneRIF Biological Term Annotations	1.0	null
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48588
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2752
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.943584
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SE5C-2126-SM-4BRUJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03043
PMC7893038-41598_2021_83450_MOESM3_ESM.xlsx-DBP_Baseline_EA-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GTEx Thyroid 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	4.57173
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149075_6_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03107
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.70841
Field CA3, stratum lucidum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09546
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.81
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.861
GTEX-XV7Q-0726-SM-4BRV6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14187
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferior frontal gyrus, opercular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.88745
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394367
medial superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13036
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.902073
abnormal blood circulation	MPO Gene-Phenotype Associations	1.0	null
imatinib_homo sapiens_gpl96_gds3042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RELA	ENCODE Transcription Factor Targets	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BE2-M17	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1355	DepMap CRISPR Gene Dependency	1.0	2.22403
BRD-K22488594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07227
JHUEM7	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TNKS_INHIBITION_GDS5029_281_human_SW480 KRAS-mutant colorectal cancer cell line - 16hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_9378_KO|KD_lincRNAEPS|PKR_SRP354151	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.81805
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.980628
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.10147
medial (magnocellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71774
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01199
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239844_4_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.840497
Prostate adenocarcinoma_PRAD_TCGA-VN-A88I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7893038-41598_2021_83450_MOESM3_ESM.xlsx-DBP_Baseline_AMR-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
DUSP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22045
NALM1	CCLE Cell Line Gene Expression Profiles	1.0	1.44022
Perturb_16082_KO_Hoxa9_SRP090515	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.35235
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RXRA	ENCODE Transcription Factor Targets	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.961707
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.835451
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.719
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.886747
A549_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122635
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERG	ChEA Transcription Factor Targets	1.0	null
immune system cancer	GWASdb SNP-Disease Associations	1.0	0.227394
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK4_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.55551
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13045
GTEX-S341-0326-SM-2XCAU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961701
Medial pretectal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.27581
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.60179
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21575
myeloma	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
biological_process	GO Biological Process Annotations 2015	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.04389
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34527
Perturb_5183_KD_Ssrp1_SRP094584	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59703
BRD-K37584671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48798
Perturb_5288_KD_Rpl10a_SRP064202	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.2149
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00624
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86178
HNF4G	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kinetoplastid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.102
K562_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171357
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3128_KO_Synm_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.91305
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4051
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE103372_0_v_3_smad1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6346_KO_Raptor/Mtor_SRP402130	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.52752
K562_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016953
Prostate adenocarcinoma_PRAD_TCGA-EJ-7786-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.1698
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851763
abnormal nervous system tract morphology	MPO Gene-Phenotype Associations	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
myeloma	GWASdb SNP-Disease Associations	1.0	0.534605
Collagen disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
RELA_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50191826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25405
regulation of jnk cascade	GO Biological Process Annotations 2015	1.0	null
heart_6a	HPA Tissue Sample Gene Expression Profiles	1.0	0.932037
H3K27ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
red nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.992828
Dendritic filopodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.534
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.828826
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Perturb_10681_KO_Gtf2ird1_SRP074330	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
mantle zone of r10BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17379
Multiple Myeloma	HuGE Navigator Gene-Phenotype Associations	1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paraventricular nucleus, peduncular or principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10915
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
polymorph layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29324
ISL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02443
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86178
BRD-K67862892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62576
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44617
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	1.0	1.14419
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77877
SMARCC1	ENCODE Transcription Factor Targets	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047079
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RT-112	GDSC Cell Line Gene Expression Profiles	1.0	1.50269
IL17RD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1581
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0843
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.71457
mania	GWASdb SNP-Phenotype Associations	1.0	0.552815
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.91602
abnormality of the liver	GWASdb SNP-Phenotype Associations	1.0	0.09736
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.824036
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5439
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84582
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
intermediate stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.26267
Lung adenocarcinoma_LUAD_TCGA-55-6978-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3416_KO_Cdx2/Apc_SRP093647	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-0526-SM-2YUMJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1388
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VAMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1026
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4726_KO_Irx3_ERP116672	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
SYK_druginhibition_152_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.56958
intercalated amygdaloid nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39937
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70923850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66931
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126776_0_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hematologic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96737756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85286
Lung adenocarcinoma_LUAD_TCGA-44-6778-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.700481
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Tozasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156035
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H28	GDSC Cell Line Gene Expression Profiles	1.0	1.42151
Perturb_4276_KO_Smad2/Smad3_SRP132215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.4264
K562_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174081
GTEX-WRHU-0926-SM-4E3IG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907971
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04548
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52311
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6681-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cholelithiasis	GWASdb SNP-Phenotype Associations	1.0	0.495071
A549_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240683
PMC10140619-mmc5.xlsx-Beta3_ConVsBSL-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PEER	CCLE Cell Line Gene Expression Profiles	1.0	2.02423
Lung squamous cell carcinoma_LUSC_TCGA-43-3394-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26114
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.947314
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.911124
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VDR-24787735-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GATA1_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59960811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.05666
GSE120781,GSE174528_4_v_1_ctcf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
undetermined	GeneRIF Biological Term Annotations	1.0	null
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal nervous system morphology	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
IRF3	ENCODE Transcription Factor Targets	1.0	null
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.070343
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.40743
Perturb_16720_Mut_Lmna_SRP309326	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.69521
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SMARCC2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K80439500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71474
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU475	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51382
A3-KAW	GDSC Cell Line Gene Expression Profiles	1.0	2.34451
A549_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155007
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.890433
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043241
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.657592
Perturb_3075_KO_Ctdspl_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.77081
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90912
nasal inflammation	MGI Mouse Phenotype Associations 2023	1.0	null
GSE200189,GSE200255_0_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SARS-CoV_48Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.45686
Perturb_4222_KO_Utx_SRP117662	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.45677
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.182
BRD-A31916785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34633
colon_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.857101
JHOS2	CCLE Cell Line Gene Expression Profiles	1.0	1.51565
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3192	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
OCILY19	DepMap CRISPR Gene Dependency	1.0	6.06704
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28373
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854878
ventropallial prepiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0334
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
rostral ventrolateral reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0876
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_13232_OE_Rnaseh1_SRP056871	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.18013
IRF3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYJK-1126-SM-3NM9Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14645
BRD-K25056189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73131
Perturb_14662_KO_Ogt_SRP198294	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Perturb_2377_KD_Cdk8_SRP292215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.84792
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04057
GTEX-WRHU-1026-SM-4E3ID	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21726
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166004_1_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826579
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OXRN-0526-SM-2I5EN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50239
Perturb_5305_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP101434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.44058
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
SP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58721
A549_PF-573228_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156673
Perturb_2232_KO_Rela_ERP122918	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.77623
A549_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021723
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
superficial stratum of r2BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13781
intracranial hemorrhage	MPO Gene-Phenotype Associations	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9366
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85110576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16726
Perturb_5710_KO_Dgcr8_SRP043436	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83898323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23186
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	1.55887
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of InsCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01144
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMARCC2	ENCODE Transcription Factor Targets	1.0	null
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.10969
GTEX-PX3G-1526-SM-48U11	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826349
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053293
Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59831227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.599
Celecoxib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0126354
RERF-LC-MS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HHV8_72Hour-BEC_20080955_GSE16354	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.13029
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.831584
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.37271
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Visceral heterotaxy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
GTEX-SIU8-0626-SM-2XCDN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88209
BRD-A12166214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56545
PML	ENCODE Transcription Factor Targets	1.0	null
UBE2V1	Pathway Commons Protein-Protein Interactions	1.0	null
CALU1	CCLE Cell Line Gene CNV Profiles	1.0	1.59169
GSE157960_0_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03417
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IL-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OC316	CCLE Cell Line Gene CNV Profiles	1.0	1.33528
HCFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17509
BRD-K27352194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13764
GSE111035,GSE111040_8_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.970108
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57634
hsa-miR-921	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ZR-75-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20594
regulation of signaling	GO Biological Process Annotations 2015	1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.50642
Lung squamous cell carcinoma_LUSC_TCGA-22-4593-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98586629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04642
CHKA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17309
BRD-K91467755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14478
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.99885
musculoskeletal system disease	GWASdb SNP-Disease Associations	1.0	0.142625
BRD-K86938753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31834
rifampicin-2487	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.097672
Field CA1, stratum pyramidale	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28391
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92767663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16716
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81189877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3199
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14434
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15493
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.908642
regulation of stress-activated protein kinase signaling cascade	GO Biological Process Annotations 2015	1.0	null
bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.209583
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214704
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988322
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06184
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.80014
Multiple Myeloma	CTD Gene-Disease Associations	1.0	2.88009
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71251
BRD-K68605096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67415
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2456
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25569
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-2226-SM-4DXTN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26555
FDXACB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28428
biological regulation	GO Biological Process Annotations 2015	1.0	null
Perturb_11080_KD_Gls2_SRP326675	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.69317
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RH30	DepMap CRISPR Gene Dependency	1.0	2.102
obstructive hydrocephaly	MGI Mouse Phenotype Associations 2023	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10T-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nucleus of the trapezoid body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00432
PPARGC1A_KO_GDS2391_299_mouse_brain striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910912
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
496100671_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44131
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
ISHIKAWAHERAKLIO02ER	CCLE Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the mandible	GWASdb SNP-Phenotype Associations	1.0	0.690584
Perturb_4345_KO_Tln1_SRP378238	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1332
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BHLHA15_KO_GDS4341_145_mouse_pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K51790412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40291
attention deficit hyperactivity disorder	GWASdb SNP-Disease Associations	1.0	1.20685
subarachnoid space	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.490619
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23239
Cyclosporin A_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0148959
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	161.407
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Patent ductus arteriosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
blood pressure	GAD Gene-Disease Associations	1.0	null
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34121
H3K9ac_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-24	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE212628_2_v_1_mier1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
BRD-K20454972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31433
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased body size	MGI Mouse Phenotype Associations 2023	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.255528
BRD-K97276563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32703
HLF	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58867
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24117
bronchial disease	GWASdb SNP-Disease Associations	1.0	0.947208
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A677-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12806_OE_miR106b_ERP132601	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.09019
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_JNJ-7706621_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125936
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352759
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52187
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T6MO-1526-SM-4DM57	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1691
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24331
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3468
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32706
GTEX-U3ZN-2626-SM-3DB7T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985298
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02555
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
maxillary sinus inflammation	MGI Mouse Phenotype Associations 2023	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
multiple myeloma	GAD Gene-Disease Associations	1.0	null
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K36me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.09195
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HG-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15663_KD_Hnrnpu_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.73171
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	178.71
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08634
GSE166004_5_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MO-1426-SM-4DM73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53119
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE131161_5_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4424
SNU81	CCLE Cell Line Gene CNV Profiles	1.0	1.7237
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29M-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08817808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0724
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15792
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.958249
PMC10140619-mmc5.xlsx-Rank_Beta1-Beta3-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14564_KO_Ubap2l_SRP296872	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
superficial stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08828
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18959
COLO680N	DepMap CRISPR Gene Dependency	1.0	2.18666
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-TK-A8OK-01A-22R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70685076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01206
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03456
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_15793_KD_Nrl_SRP380201	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.56259
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2639
IA-76-ZU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218516
ETS1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
phosphorylation	GO Biological Process Annotations 2015	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143551
molecular_function	GO Molecular Function Annotations 2015	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.69314
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16898
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal paranasal sinus morphology	MPO Gene-Phenotype Associations	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-X8HC-2726-SM-46MUA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876666
K562_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189568
Liver hepatocellular carcinoma_LIHC_TCGA-MR-A8JO-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.868577
Kidney renal clear cell carcinoma_KIRC_TCGA-T7-A92I-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_5870_KD_Cpsf7_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.24466
HdhQ111/111_Knock-in_GDS4534_744_mouse_Striatum and cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Parataenial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27533
RUNX1	ChEA Transcription Factor Targets	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01258
GSE233679_14_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29346
regulation of cellular response to stress	GO Biological Process Annotations 2015	1.0	null
MCF7_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01612
Perturb_17768_KO_Rbm24_SRP268577	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.80265
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01054
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43876
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33243
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dilated third ventricle	MGI Mouse Phenotype Associations 2023	1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATF3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KU-19-19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84284
RFX5	ENCODE Transcription Factor Targets	1.0	null
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166335
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cilium morphogenesis	GO Biological Process Annotations 2015	1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89993
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141747
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148085
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73841
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08738
PMC9314667-Table_1.xlsx-Regulons-MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
4EGI-1_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0275292
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.901694
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898231
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6881
Bipolar disorder x sex interaction	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.51549
Fatty Liver	CTD Gene-Disease Associations	1.0	1.44954
MAX	ENCODE Transcription Factor Targets	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8435-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
retina	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.35248
MYC	ENCODE Transcription Factor Targets	1.0	null
Arrhythmogenic right ventricular dysplasia 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.434
TCF7L2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.09112
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81976
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846885
mantle zone of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45868
NFYA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.997051
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Malignant tumor of pancreas_saliva_GSE14245	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.28103
abnormality of the abdomen	GWASdb SNP-Phenotype Associations	1.0	0.0488
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	2.33314
Perturb_1740_KO_Usp15_SRP290189	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.67993
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13255_KD_Paf1_SRP083772	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
EW-13	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60388
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
gammopathy	GeneRIF Biological Term Annotations	1.0	null
Hydrocephalus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.8
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72517
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140996
IFNAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23273
MCF7_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182294
chr3_41827873_C_T_b38	GTEx eQTL 2025	1.0	2.67035
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828038
Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26962
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.847675
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_MAP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
lateral amygdaloid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47005
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAJIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32153
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FUOV1	CCLE Cell Line Gene Mutation Profiles	1.0	null
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.48604
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alcohol Consumption	DisGeNET Gene-Phenotype Associations	1.0	null
GSE195568_6_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
STK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21722
Bipolar Disorder_frontal cortex_GSE5388	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.49066
K562_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153172
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18129
H3K4me1_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135421
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02461
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.962521
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.845972
BRD-K84260700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22048
BEND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51535
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23084
Vascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.182
pyramidal layer of taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30175
m1Lim (VL) part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5402
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TP63	ChEA Transcription Factor Targets	1.0	null
GTEX-TSE9-0726-SM-3DB8C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38182
Habenular trigone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
ADAM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53061
REH	GDSC Cell Line Gene Expression Profiles	1.0	1.5098
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.43733
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5149_KO_Thap11_ERP126456	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.89602
BRD-K57200567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36698
cancer	GWASdb SNP-Disease Associations	1.0	0.072093
GSE211474,GSE212779_0_v_1_phf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMURF1	Hub Proteins Protein-Protein Interactions	1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831605
CREM	ChEA Transcription Factor Targets	1.0	null
CAOV-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171116
EZH2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172253
Paraventricular hypothalamic nucleus, magnocellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52122
BRD-K17965071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24117
K562_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166703
brain disease	GWASdb SNP-Disease Associations	1.0	0.161669
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_10853_KO_Mkp1_SRP169858	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Darinaparsin_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0133062
ZCCHC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40539
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
arterial stenosis	GWASdb SNP-Phenotype Associations	1.0	0.390783
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	41.119
lateral ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.169784
tunica media	GAD Gene-Disease Associations	1.0	null
A549_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192345
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU201	CCLE Cell Line Gene CNV Profiles	1.0	2.38958
Perturb_17322_KO_Ppp2ca_SRP330476	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.59781
BRD-K88070373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34275
EGR1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13592
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pyramus (VIII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05426
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32951
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22462
BRD-K74972903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33655
GTEX-XYKS-2426-SM-4AT43	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16131
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Perturb_5869_KD_Cpsf7_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GATA3_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X8HC-2826-SM-46MWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03251
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K46588240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41039
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.859297
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_14764_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.99959
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63447
Perturb_13231_OE_Rnaseh1_SRP056871	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-18.9208
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6951_KO_Rbm20_SRP328560	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.76424
Perturb_11846_KO_Tmem106b_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.71401
Acetazolamide_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.020426
atherosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.477068
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09938
Rectum adenocarcinoma_READ_TCGA-DC-5869-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r10 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08252
KMBC2	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-S32W-1326-SM-4AD5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35104
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
Perturb_14920_Mut_Atxn3_SRP155020	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.85514
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23208
WSU-NHL	GDSC Cell Line Gene Expression Profiles	1.0	1.81546
intermediate stratum of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.39437
GSE123372,GSE123373_1_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.938265
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.905791
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LD-39-FL02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262975
Perturb_12038_KO_Trps1_SRP201986	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.09555
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CALML6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22749
OCILY3	CCLE Cell Line Gene CNV Profiles	1.0	1.36401
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.827648
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200555
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04243
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4690-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33912919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01491
GTEX-X5EB-0626-SM-46MVQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920058
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.62992
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.235
Perturb_13305_KD_Zfp207_SRP308674	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.96866
SW1271	CCLE Cell Line Gene CNV Profiles	1.0	1.45233
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
domed cranium	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44017
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3566
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5836-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-SYMBOL_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Mobilized_CD34_Primary_Cells_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.15347
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.96992
BRD-K10505056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93029
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eosinophilia	GWASdb SNP-Disease Associations	1.0	0.947208
LS411N	DepMap CRISPR Gene Dependency	1.0	8.57632
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KAT2B	ENCODE Transcription Factor Targets	1.0	null
anion binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952072
TGBC52TKB	DepMap CRISPR Gene Dependency	1.0	2.62174
Bipolar Disorder	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MED26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19416
anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.856052
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6088-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0448219
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
GTEX-WK11-0626-SM-3NMAV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46668
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113728
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877118
NCIH1650	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6009
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35719
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2172	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01036
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chr3_41826788_A_T_b38	GTEx eQTL 2025	1.0	2.24815
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17889
496100480_HIP_no dementia_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.57743
NR2F2	ENCODE Transcription Factor Targets	1.0	null
FAM32A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06535
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aortic dissection	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.977
Ependymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.643
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0261978
SNU349	CCLE Cell Line Gene CNV Profiles	-1.0	-2.21018
artery disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.003184
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.26425
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.883405
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60524
microtubule cytoskeleton organization	GO Biological Process Annotations 2015	1.0	null
BRD-A41916216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51713
regulation of JNK cascade	GO Biological Process Annotations 2023	1.0	null
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13296
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
Dihydroartemisinin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.018387
Armadillo-like helical	InterPro Predicted Protein Domain Annotations	1.0	null
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RING1B-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
NYAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06733
MCF7_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00881828
GTEX-UPK5-1126-SM-3GAEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857428
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A39660642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12439
Perturb_12674_KD_Sox10_SRP191908	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.45959
GTEX-REY6-0426-SM-2TF5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24711
Medullary reticular nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16144
intermediate pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12284
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147683
H3K9ac_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ASH-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Infralimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23376
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3387-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11544636-CCS3-18-e12047-s001.xlsx-Supplementary_Table_S7-Supplementary_Table_S7_Four_cluster_profiles_using_short_time-series_expression_miner_STEM_algorithm_in_A673pTERshEWS_FLI1_model_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH3255	CCLE Cell Line Gene Expression Profiles	-1.0	-1.89493
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99531
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04301
superior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.923429
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1149
NCI-H1048	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71422
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49601
Perturb_4680_KO_Psip1_SRP153901	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.5172
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.3539
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QV31-0726-SM-3GAEG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863338
multiple	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-556-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of JNK cascade	GO Biological Process Annotations 2025	1.0	null
caudate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44922
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4605-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15662_KD_Hnrnpk_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.56692
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoskeleton organization	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16105
MCF7_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215636
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12606_KO_Lin28a/Lin28b_SRP300815	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
JHOS-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8419-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of facial skeleton	GWASdb SNP-Phenotype Associations	1.0	0.388393
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVK18	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51265
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_EA-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390181
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75647
increased susceptibility to otitis media	MGI Mouse Phenotype Associations 2023	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2901-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53562
OVMIU	DepMap CRISPR Gene Dependency	1.0	3.32902
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-1_UCSC_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XK-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7210-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46107
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921967
RAD21	ENCODE Transcription Factor Targets	1.0	null
SMAD3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2292
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LC1SQSF	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4981
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03662481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09149
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CFAP298	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50696
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal axial skeleton morphology	GWASdb SNP-Phenotype Associations	1.0	0.15618
USF1_02_26	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58896
ESR1	ChEA Transcription Factor Targets	1.0	null
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	158.638
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.9788
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12994
Perturb_3132_KO_Tmem97_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.38397
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_Q1_vs_Q4-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
Perturb_3118_KO_Rilp_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.56606
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7927379-12864_2021_7476_MOESM1_ESM.txt--MI_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
decreased food intake	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_15679_KD_Srsf7_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.4877
fallopiantube_8e	HPA Tissue Sample Gene Expression Profiles	1.0	0.911585
abnormal subcommissural organ morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K23499378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61569
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	84.989
chaperone-mediated autophagy translocation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.687
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36388
MCF7_Luminespib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00877637
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872411
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10826
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81E-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.73544
KATOIII	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAP3K1_knockout_245_GSE39240	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.16728
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149010_0_v_4_dars2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136545
USF1	ENCODE Transcription Factor Targets	1.0	null
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	295.727
Perturb_5318_KD_Ctnnb1_SRP130920	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Diastolic blood pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.13979
Perturb_15228_KO_Trps1_SRP201986	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.14458
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56808
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126746
BRD-K00970182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11323
Piriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12701
r10 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56736
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219916
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955872
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55317
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18103
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145639_7_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal stomach morphology	MGI Mouse Phenotype Associations 2023	1.0	null
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00499
NCI-H250	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
regulation of stress-activated mapk cascade	GO Biological Process Annotations 2015	1.0	null
GTEX-TSE9-0626-SM-3DB8B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859493
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3106_KO_Olah_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.68512
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825664
prostate	HPA Tissue Protein Expression Profiles	-1.0	-1.03065
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
GTEX-SN8G-0926-SM-4DM5I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915714
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.710832
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37837
Perturb_17_OE_Carhsp1_SRP217699	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.47238
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66566
SNB19	CCLE Cell Line Gene CNV Profiles	1.0	1.39612
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
increased susceptibility to otitis media	MPO Gene-Phenotype Associations	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPIF_KO_GSE23028_45_mouse_heart (8 wk)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6592-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12853
nr2c2_20864514_liver_1yo_lof_mouse_gpl4134_gse21903	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.06619
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.901994
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dipyridamole-4656	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0826-SM-32PMC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91742
TM31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46389
HEY	DepMap CRISPR Gene Dependency	1.0	2.53244
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.82249
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115896
regulation of p38mapk cascade	GO Biological Process Annotations 2015	1.0	null
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism organelle organization	GO Biological Process Annotations 2015	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
decreased brain ependyma motile cilium length	MGI Mouse Phenotype Associations 2023	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_15744_KO_Cyp4v3_SRP358013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.0172
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XV7Q-2926-SM-4BRUL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969514
Perturb_3093_KO_H1foo_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.7735
HES3_KD_GSE64449_187_mouse_Min6	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
intermediate stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04677
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05738
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04575
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3121
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.504
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.119351
Perturb_11167_KO_Tsc1|Pten_SRP156216	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.31406
Perturb_1917_KO_Arhgef2_SRP186268	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.3979
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974931
myocardial infarction	GWASdb SNP-Phenotype Associations	1.0	0.834343
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23125
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infralimbic area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08779
cervix, uterine	HPA Tissue Protein Expression Profiles	-1.0	-1.03065
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
lateral part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13036
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72224143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92597
MCF7_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010606
Mesendoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
Brain	dbGAP Gene-Trait Associations	1.0	0.17264
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8955
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0522
Perturb_3072_KO_Caskin2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.18549
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	55.5373
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
16455954-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
efo21	HPA Cell Line Gene Expression Profiles	-1.0	-0.833485
Perturb_5251_KO_Klf2_SRP311785	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZY-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paraproteinemias	DisGeNET Gene-Disease Associations	1.0	null
GSE148066,GSE157787_11_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94751306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38086
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A-CA-04-2009(H1N1)_7Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.43277
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79854
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSC22D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05817
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_17824_KO_Kansl3_SRP225948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.00734
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-0426-SM-3GIJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00723
Perturb_10718_KO_Hck_SRP340501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.29134
THAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33347
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.06571
Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HEC1B	CCLE Cell Line Gene CNV Profiles	1.0	1.86598
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_KAT5_22196727	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07531
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09661
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CNOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07467
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6224-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A181-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.29347
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.102001
BRD-K11310449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34975
TGW	GDSC Cell Line Gene Expression Profiles	1.0	1.57081
abnormal brain ependyma morphology	MPO Gene-Phenotype Associations	1.0	null
A549_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131896
G402	CCLE Cell Line Gene Expression Profiles	1.0	1.35836
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46528
BRD-K93442068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50704
Perturb_11857_KO_miR301a_SRP131007	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.80376
Brain disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.182
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33281
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04195
GSE149075_3_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.1074
RPMI8402	CCLE Cell Line Gene Expression Profiles	1.0	1.90864
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79261
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00811
CH-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.614
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.920294
Hematopoietic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44894536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28357
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.374404
Female reproductive endometrioid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149075_3_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
enlarged brain ventricles	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_3088_KO_Fam210b_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.74616
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.943859
BRD-K42976515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7484
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13917
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.94
SNU81	CCLE Cell Line Gene Mutation Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
NB(TU)1-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044521
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
atp binding	GO Molecular Function Annotations 2015	1.0	null
Ammon's horn	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19474
BEND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44592
Subcortical maternal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.922
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.171535
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11874
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60823407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37327
MCF7_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106822
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3569
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9677
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
CEP170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1529
A549_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155497
Perturb_1965_KO_Nrf2_SRP371099	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.5529
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24515
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.926228
8-MG-BA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5021
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.3496
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148252_0_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH28	CCLE Cell Line Gene CNV Profiles	-1.0	-2.60128
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOT4-1126-SM-4B66E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55425
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.058828
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06708
PMC8185471-mmc7.xlsx-DEGs-SOX15_peaks-Unnamed_2_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
Posterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06547
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	1.05551
lambdoid septal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23335
MCF7_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216114
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.46933
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02733
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21254338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1338
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50609
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
HEC59	CCLE Cell Line Gene Mutation Profiles	1.0	null
A549_Mocetinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145185
Finasteride_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0173233
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.908201
GSE239844_6_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25549
A549_Divalproex Sodium_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129981
Celecoxib_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0148005
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828038
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vertical nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53052
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37051
BRD-K24748087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.04672
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.83482
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08194
bipolar disorder	GWASdb SNP-Disease Associations	1.0	0.647686
Perturb_6188_KO_Mecp2_SRP188207	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.72314
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8015_KD_Crebl2_SRP214573	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.59853
SAS acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.634
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49205
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5587-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12071_OE_Tfap2a_SRP067296	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.8919
Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mortality/aging	MPO Gene-Phenotype Associations	1.0	null
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Multiple myeloma and monoclonal gammopathy	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
Sarcoma_SARC_TCGA-DX-A7EU-01A-22R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of VPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21116
GTEX-S3XE-1626-SM-3K2AJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1339
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00699117
Medial septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28584
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	1.56312
hematologic cancer	GWASdb SNP-Disease Associations	1.0	0.227394
NCI-H2081	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K83238251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24432
Perturb_11761_KO_Arg2_SRP198795	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.66312
abnormal gallbladder morphology	GWASdb SNP-Phenotype Associations	1.0	0.361413
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58838
GSE240027,GSE240030_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15678_KD_Srsf6_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.0845
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931006
GTEX-T6MO-1226-SM-4DM5S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901489
K562_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236859
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182828
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040338
KY821	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999511
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2170	CCLE Cell Line Gene Mutation Profiles	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.36083
subcallosal cingulate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21796
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36303
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.79195
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1937	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89407
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
postnatal growth retardation	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_276_KD_USP13_SRP343502	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.90968
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26503
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3101_KO_Mid2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.3109
GTEX-T2IS-0526-SM-32QP9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951746
periventricular stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22763
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3347-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89967940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9035
A549_SRT2104_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115674
GSE248883_0_v_1_shmt2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWCY-1426-SM-48TCT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30715
PMC12152148-41420_2025_2541_MOESM3_ESM.xlsx-AR-IP-DHT_peak-gene-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Amphisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.663
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.21568
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.921439
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_12568_KD_Sufu_SRP194252	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
chr3_41963289_A_G_b38	GTEx eQTL 2025	1.0	1.90937
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	1.0	2.28468
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	2.66034
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.93859
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18909
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JL-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51157416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06762
Lateral dorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28759
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
u2197	HPA Cell Line Gene Expression Profiles	1.0	1.10029
Intellectual disability	ClinVar Gene-Phenotype Associations 2025	1.0	null
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.9073
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K15380626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19316
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.277
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.38164
EP300_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DHFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15588
BRD-K96778009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70449
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46217
GTEX-P78B-2526-SM-3P5ZY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31336
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.12936
PMC7687904-41598_2020_75770_MOESM1_ESM.xlsx-SP2-Gene_SP2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151315
esculetin-3120	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
chr3_41968234_A_G_b38	GTEx eQTL 2025	1.0	3.77697
premature death	MGI Mouse Phenotype Associations 2023	1.0	null
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208629
Habenula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.736
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13256_KD_Phf5a_SRP083772	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
MCF7_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00942026
K562_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243962
Perturb_5867_KD_Cpsf6_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.22375
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54382
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7429
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_InDel-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
OVISE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_1860_KO_Ifnar_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.1547
EGR1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
42MGBA	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09389
Lung squamous cell carcinoma_LUSC_TCGA-85-8352-01A-31R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
HCC95	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97515
15273739-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.977384
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98504
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.836129
PMC6344081-elife-40364-supp5.xlsx-PLZF_peaks_H3K27Ac_unchanged-Unnamed_10_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BCAT-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.283297
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15567
organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05571
NAXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11287
BRD-K22265882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48777
Perturb_15664_KD_Srsf1_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.39814
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88878
bone marrow cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
p3 portion of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92487
Chronic Lymphocytic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
TTF2	ChEA Transcription Factor Targets	1.0	null
HROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0406
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25429
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33384
AR-21572438-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
18614019-TableS4d	GeneSigDB Published Gene Signatures	1.0	null
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017229
cell part morphogenesis	GO Biological Process Annotations 2015	1.0	null
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19784
intermediate stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05927
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.231236
anatomical structure development	GO Biological Process Annotations 2015	1.0	null
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28491
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WH-01A-22R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4516_Mut_Ep400_SRP081300	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.42564
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09941
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.950155
ATF3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
substance-related disorder	GWASdb SNP-Disease Associations	1.0	0.358594
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.62789
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890448
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
19808870-ST1	GeneSigDB Published Gene Signatures	1.0	null
Perturb_14923_Mut_Atxn3_SRP155020	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.36759
periventricular stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10915
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Pracinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00914994
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187278
HUTU80	CCLE Cell Line Gene Expression Profiles	1.0	1.87033
VDR-24763502-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47349
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A2-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.459
18614019-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
ESET-19884257-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07052
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241181
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.958096
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
A549_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150853
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23695
superficial stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17033
BRD-K12564766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4253
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.0936
HEC251	CCLE Cell Line Gene Mutation Profiles	1.0	null
cellular component organization	GO Biological Process Annotations 2015	1.0	null
GTEX-WHPG-1026-SM-3NMBA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12955
K562_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219949
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OC314	DepMap CRISPR Gene Dependency	1.0	2.72159
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Photosystem I reaction center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34801
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.182
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11385366-Table2.xlsx-DBP-Overlapped_Gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV MA15_Day7-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.90829
Perturb_1858_KO_Nrf2_SRP371099	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.37028
chr3_41914222_G_A_b38	GTEx eQTL 2025	1.0	2.29226
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26257
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73092207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60302
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7594
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85725
Perturb_17260_KO_Gja1_SRP247546	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-2626-SM-4DXV2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32611
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851006
NCIH1573	DepMap CRISPR Gene Dependency	1.0	3.13164
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145801
E2F4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.57985
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GM-06B-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336798
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.970889
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51624
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Quisinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169547
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92315
Perturb_15661_KD_Hnrnpc_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.34444
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A6UF-01A-23R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51219
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.26187
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_3113_KO_Pxdc1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.52768
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24952
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14523
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22782
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05961
BRD-K28559679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14208
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.25545
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02513
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7866901__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Renal tubule	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_10349_KD_Myc_ERP119985	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.26646
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPI-PLD_OE_GDS2049_176_human_Hepatoma HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18769
regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
salicyl-alcohol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27866
Perturb_3085_KO_Fads1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.49081
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-387	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176071
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26297
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-3B-A9HP-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161444
Perturb_9395_OE_SOX9_SRP201900	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.38297
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3062_KO_Myh6_SRP201871	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.5021
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07129
hsa-miR-873	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.01083
GTEX-T8EM-1026-SM-3DB7M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883011
Perturb_1335_KO_Esrra/Esrrg_SRP143464	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.32716
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JHOS2	CCLE Cell Line Gene CNV Profiles	1.0	1.75914
Tunica Media	dbGAP Gene-Trait Associations	1.0	0.248525
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hemorrhage	MPO Gene-Phenotype Associations	1.0	null
MCF7_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151881
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.912202
A549_TMP195_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130593
MXI1	ENCODE Transcription Factor Targets	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14523
Slit-Robo signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.028
PMC11184788-40164_2024_526_MOESM4_ESM.xls-MSC-EV_proteins-Unnamed_4_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
overnutrition	GWASdb SNP-Disease Associations	1.0	0.441999
GSE114232_10_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275829
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41519
Perturb_12695_OE_Hoxb13_SRP250504	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.1713
DIFI	DepMap CRISPR Gene Dependency	1.0	11.4091
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241924
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0102
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041994
Atg12-Atg5-Atg16 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.832
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834296
developmental disorder of mental health	GWASdb SNP-Disease Associations	1.0	0.178611
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00183
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67834
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10497
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
DNAJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10418
olivary pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01492
Lung squamous cell carcinoma_LUSC_TCGA-92-7340-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
A549_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105665
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.993105
hsa-miR-920	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06439
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_943_KO_Sftpa1_SRP246320	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.62761
BRD-K27728416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08237
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041095
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.119351
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Monoclonal gammopathy of undetermined significance	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.622185
hsa-miR-4300	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K62263376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01001
A549_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174823
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal brain development	MPO Gene-Phenotype Associations	1.0	null
Perturb_11733_KD_Dstyk_SRP396092	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.9223
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.7265
layer 4 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1246
Perturb_1885_KO_Mettl14_SRP269254	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.7505
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.202006
BRD-K81110981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40527
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD3-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SKBR3	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.09196
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.77477
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.47213
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K80724972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91776
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.969164
r2 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13856
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07263
Hematologic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PFSK1	DepMap CRISPR Gene Dependency	1.0	5.31071
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41434
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38665228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9466
POLR2A_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rheaume et al.Nat Commun.34_Retina_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
uterus	GTEx Tissue Gene Expression Profiles	1.0	1.04209
Subventricular zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
ZIC2_01_121	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.42789
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09022
MCF7_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0104896
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3361
regulation of locomotion	GO Biological Process Annotations 2015	1.0	null
GTEX-NFK9-0326-SM-3MJGV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947031
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
cardiovascular system phenotype	MPO Gene-Phenotype Associations	1.0	null
FOXP3	ChEA Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Multiple myeloma (hyperdiploidy)	GWAS Catalog SNP-Phenotype Associations	1.0	0.522843
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A6UC-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EOLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23143
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nicotine dependence	GWASdb SNP-Disease Associations	1.0	0.981566
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
Diastolic Blood Pressure	DisGeNET Gene-Phenotype Associations	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.73795
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
TBCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27071
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.89399
Lung squamous cell carcinoma_LUSC_TCGA-56-8082-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular developmental process	GO Biological Process Annotations 2015	1.0	null
K562_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158792
GTEX-S32W-1626-SM-4AD6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50655
CI1	CCLE Cell Line Gene Expression Profiles	1.0	1.81108
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5281_KO_Ddx6_SRP137728	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.98048
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.934827
u26684	HPA Cell Line Gene Expression Profiles	1.0	1.31356
core part of DTg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81706
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Auranofin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0201664
PMC11975397-JPN-240126-at-1.pdf-38-ZNF778_ZNF778	Rummagene Transcription Factor Associations 2026	1.0	null
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.21571
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.982132
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12318
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDC14C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58124
SNUC5	CCLE Cell Line Gene Mutation Profiles	1.0	null
A549_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197058
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02198
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0139
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56843
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44014
K562_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215928
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8471
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66311249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00155
Perturb_13218_KO_Dres1_SRP127601	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.35266
Aortic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.747
NCI-H1869	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S32W-1226-SM-4AD67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01093
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166004_3_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
MPDZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29019
asthma	GWASdb SNP-Disease Associations	1.0	0.947208
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64114
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cutis laxa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
bone marrow	HPA Tissue Gene Expression Profiles	1.0	0.906638
BRD-K16387460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12582
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.79511
MCF7_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145751
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5711-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5539_KO_Fh1_ERP138019	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
abnormal respiratory motile cilium morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62426
anthraquinone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93043
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A69Q-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40119
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.942983
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6117
TOLEDO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31945
Perturb_17767_KO_Prdm16_SRP238935	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.60429
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHOM1	CCLE Cell Line Gene Expression Profiles	1.0	1.39851
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	1.23818
non-growing cell tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.941
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsal tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16335
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919091
BRD-K61943321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05303
MCF7_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116508
GTEX-XV7Q-1626-SM-4BRWC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975251
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K90059152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4772
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SRF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32259
MCF7_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136834
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.85893
Prostate adenocarcinoma_PRAD_TCGA-EJ-5521-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2392
PDRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29495
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0728
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.937
MCF7_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015037
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.63949
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10184
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04271
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TNFRSF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0479
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XXEK-2026-SM-4BRVE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911781
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DV-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14669
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bbsome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.2905
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	HPA Tissue Protein Expression Profiles	-1.0	-1.03065
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37681
Paraventricular hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52829
Multiple myeloma	GWAS Catalog SNP-Phenotype Associations	1.0	0.405958
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5795_KO_Stat3_ERP105170	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-1826-SM-4LVM4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945317
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0104
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124375_10_v_9_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Basolateral amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38358
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-1226-SM-3GIJ6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98078
leukocyte disease	GWASdb SNP-Disease Associations	1.0	0.358174
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZT-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137641
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40187
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37588
POU3F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03993
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.15897
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MU-A5YI-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148313
CKAP2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28762
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.47376
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.62212
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.06033
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.966055
Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13147
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracerebral hemorrhage	MPO Gene-Phenotype Associations	1.0	null
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10854
NCIH1373	CCLE Cell Line Gene Mutation Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050884
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.098891
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cervix uteri	GTEx Tissue Gene Expression Profiles	1.0	1.83763
GSE88819_1_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.921439
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061773
r10 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18509
Perturb_5540_KO_Fh1_ERP138019	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-WEY5-0226-SM-3GIKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27621
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12506
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8MGBA	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA1_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47802
GSE233679_6_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of localization	GO Biological Process Annotations 2015	1.0	null
A549_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119632
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPN-2726-SM-2I5H4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943793
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18842
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7091_KO_Ctnnb1_SRP270859	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.64019
SMAD4	ChEA Transcription Factor Targets	1.0	null
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30111
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_5_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172203
basomedial amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23499
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5543_KD_Foxa2_ERP138019	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.79094
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.51969
BRD-K95142134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11087
HS939T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59048
Perturb_12013_KO_B2_Mm2_SRP374407	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.15092
Perturb_14925_OE_HsATXN3_SRP155020	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.9998
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38425
HUPT4	CCLE Cell Line Gene CNV Profiles	1.0	1.79728
NCI-H2347	COSMIC Cell Line Gene Mutation Profiles	1.0	null
muscle tissue disease	GWASdb SNP-Disease Associations	1.0	0.233497
H3K27ac_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126858
choroid plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.202081
bone marrow cancer	GWASdb SNP-Disease Associations	1.0	0.466435
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_Pre-Pro-B-Cells_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Trachea	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915649
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.942
Perturb_5541_KO|KD_Fh1|Foxa2_ERP138019	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045703
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00718237
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32855
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ERG-20517297-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.591
superficial stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30135
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67765
Uterine epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
obstructive lung disease	GWASdb SNP-Disease Associations	1.0	0.408812
Perturb_7066_KO_Lrpprc_SRP110979	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.51764
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.767
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PARP	MotifMap Predicted Transcription Factor Targets	1.0	null
Promastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal ependyma motile cilium morphology	MPO Gene-Phenotype Associations	1.0	null
GTEX-QDVJ-0426-SM-2I5FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877615
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878389
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NFYB_NFYB	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298123
GTF2H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03563
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75007044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13727
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_1835_KO_Dgcr8_SRP258731	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.38803
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5419
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RABL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55986
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02452
Perturb_1288_KO_Pank1/Pank2_SRP194974	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.41269
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78674
Sarcoma_SARC_TCGA-KD-A5QT-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
diagonal part of septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63587
Pentamidine (isethionate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206195
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
H3K9ac_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7G-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
hydroxyachillin-4213	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05476
SW982	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TE15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32883
Ciliated cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7731-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-396-ZNF563_ZNF563	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.17565
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.96486
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.618024
PYGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71315
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal nervous system development	MPO Gene-Phenotype Associations	1.0	null
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30009
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CDCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3727
Contractile vacuolar membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.917
GSE184133,GSE184137_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eosinophils	dbGAP Gene-Trait Associations	1.0	0.282209
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Alendronate sodium trihydrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015074
BRD-K19652835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04004
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.643
GTEX-WOFL-0126-SM-3MJG2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826153
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26263
mRNA_SOX2_17515932	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
cerebrospinal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.501574
ESR1-22446102-UTERI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Blood pressure	GWAS Catalog SNP-Phenotype Associations	1.0	0.729497
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04384
abnormal body size	MPO Gene-Phenotype Associations	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54074
MCF7_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245715
PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_filtered-genes_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
PcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.23073
GSE202284,GSE202289_7_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-1326-SM-48U24	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858644
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24887
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22287
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346039
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873948
intermediate stratum of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62284
Perturb_4989_KO_Ythdc1_SRP212677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.10138
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1267_KD_Prmt7_SRP279352	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.94955
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
Bone marrow cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KYSE-510	GDSC Cell Line Gene Expression Profiles	-1.0	-1.90083
BRD-K17420784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29133
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27769
essential hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.373698
GTEX-X638-0326-SM-47JY1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54027
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal head morphology	MPO Gene-Phenotype Associations	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.61069
BRD-K93817456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10816
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.142445
H3K36me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K39014631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46717
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-1626-SM-2HMKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24475
protein serine/threonine kinase activity	GO Molecular Function Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZF-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCC90	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LB647-SCLC	GDSC Cell Line Gene Expression Profiles	-1.0	-2.41391
GTEX-WFG8-0426-SM-3GILD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845107
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897115
GSE140576_0_v_2_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36313
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11373
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02871
mantle zone of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16643
Perturb_1846_KO_Nox2_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.57175
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976184
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50527
BRD-K14375485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72035
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91470977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4708
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224554
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.857206
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212822
lateral spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.07862
BRD-K24877937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43756
BRD-K23614490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19248
PMC12420540-44154_2025_254_MOESM1_ESM.xlsx-supplementary_S7-FST_PI_XPCLR_TGB_VS_ZSG_gene_PATZ1	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
caudal linear (raphe) nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21481
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
coronary artery disease	GWASdb SNP-Phenotype Associations	1.0	1.30781
496100443_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16117
EP300_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.6486
prion disease	GWASdb SNP-Disease Associations	1.0	0.722673
periventricular stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.03155
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_4809_KO_Stat5b_ERP004375	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.70739
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of p38MAPK cascade	GO Biological Process Annotations 2023	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7649
OE33	GDSC Cell Line Gene Expression Profiles	-1.0	-1.62469
Perturb_16698_KO_83F24Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.5583
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A53H-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63277230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46417
HSP90-CDC37 chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
GSE180813,GSE180815_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018021
A549_Ruxolitinib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207364
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A20256229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97323
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Blood Pressure	dbGAP Gene-Trait Associations	1.0	0.820059
chr3_41810226_T_C_b38	GTEx eQTL 2025	1.0	5.46209
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
INA-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
Perturb_8400_KD_Srrm2_SRP195765	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.59356
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95415
joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.373868
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90287
TBX20-22080862-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135298
Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65329
Post bronchodilator FEV1/FVC ratio	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.066433
regulation of MAPK cascade	GO Biological Process Annotations 2023	1.0	null
BRD-K61172568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12359
Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2699
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81643
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-downregulated_in_ATF4OE-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.913528
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15966
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0262
chr3_41771612_T_C_b38	GTEx eQTL 2025	1.0	1.10217
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40318
GTEX-OHPK-1326-SM-3MJGN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00847
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25441
Perturb_9416_KD_Mecom_SRP356893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.6664
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.68733
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151532
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
ventricular system development	GO Biological Process Annotations 2015	1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0853
GSE161771_0_v_1_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
caudal group of intralaminar nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.92706
MCF7_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127446
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239573
GTEX-RU72-0126-SM-2TF6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891703
Perturb_15035_KD_Ctcflos_SRP311201	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.19695
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_7981_KD_Stag2_SRP191444	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.0401
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0728
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KMRC3	DepMap CRISPR Gene Dependency	1.0	2.43678
BRD-K56536691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24072
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927968
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26954
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05594
abnormal inflammatory response	MPO Gene-Phenotype Associations	1.0	null
PSN1	CCLE Cell Line Gene Mutation Profiles	1.0	null
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.939581
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Microfibril	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.085
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.67931
abnormal lateral ventricle morphology	MPO Gene-Phenotype Associations	1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCDHB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63707
GSE123836_2_v_0_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015821
BRD-K56470219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26208
SW620	CCLE Cell Line Gene Expression Profiles	1.0	1.37137
abnormal cell morphology	MPO Gene-Phenotype Associations	1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02576
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormalities of the peripheral arteries	GWASdb SNP-Phenotype Associations	1.0	0.390783
Prostate adenocarcinoma_PRAD_TCGA-EJ-7791-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72943
A549_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129817
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PE-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6954-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Palatine uvula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
Nuclear RNA export factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.841
BRD-K61791241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03144
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11228_KO_Srf_SRP050501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.36399
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955732
MYBL2	ENCODE Transcription Factor Targets	1.0	null
Pulse pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.9
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159175
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XO-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal tela choroidea morphology	MPO Gene-Phenotype Associations	1.0	null
kinase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5748
Lung adenocarcinoma_LUAD_TCGA-NJ-A55A-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal facial morphology	MPO Gene-Phenotype Associations	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EBC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	0.710832
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7920-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular phenotype	MPO Gene-Phenotype Associations	1.0	null
Panobinostat_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0147163
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98985
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100321_HIP_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.164
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850645
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A6BB-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97873
BRD-K09960817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3656
GTEX-W5X1-0426-SM-3GILB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890418
chr3_41720510_G_A_b38	GTEx eQTL 2025	1.0	1.63747
A549_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120042
MCF7_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00762826
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34084
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7616765-EMS198548-supplement-Data_S2.xlsx-3_DEG_2D_and_3D-D9_Up_in_3D_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Dorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08836
Phosphatidylinositol 3-kinase complex, class III, type II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.951
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.927578
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160596
NFU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27925
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22829
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149075_8_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Contractile vacuole pore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.092
MCF7_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160112
TRERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15444
GTEX-QDT8-2526-SM-48TYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27707
mood disorder	GWASdb SNP-Disease Associations	1.0	0.315974
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47653
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987766
Perturb_3097_KO_Lama4_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.0681
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
MRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29177
GTEX-S4UY-1226-SM-4AD51	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18672
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34795
BRD-K56222361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00702
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81R-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPAR-26484153-CHIP-SEQ-NCI-H1993-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280504
GTEX-U8T8-2226-SM-3DB95	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09753
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9308
K562_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188973
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXP3-21729870-TREG-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Dorsal peduncular area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.148
abnormal brain white matter morphology	MPO Gene-Phenotype Associations	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30394
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_38_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_245_KO_Clic4_SRP318761	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.14762
GTEX-U4B1-1726-SM-3DB9F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990456
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.824936
BRD-K27028848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05996
myeloma	GeneRIF Biological Term Annotations	1.0	null
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03317
lomefloxacin-3620	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT115	CCLE Cell Line Gene Expression Profiles	1.0	1.52532
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051003
GSE212628_6_v_1_mier1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868038
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6395
POLR2A	ENCODE Transcription Factor Targets	1.0	null
PSN1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32283
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_CUDC-907_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0080018
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04314
Perturb_15753_KO_Ezh2_SRP096837	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154442
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98555
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137798
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058666
Perturb_13108_KO_Mbnl1/Mbnl2_SRP045573	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.37699
regulation of plasma membrane bounded cell projection organization	GO Biological Process Annotations 2023	1.0	null
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56801
FOXP3-21729870-TREG-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283502
abnormal cerebrospinal fluid flow	MGI Mouse Phenotype Associations 2023	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.42632
Lung squamous cell carcinoma_LUSC_TCGA-43-6773-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96389533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18739
RERF-LC-AI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03944
Systolic blood pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6948
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14725
retroreuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.784
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Field CA2, stratum oriens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11563
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MT-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190235_1_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40784
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.655
regulation of cellular component movement	GO Biological Process Annotations 2015	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
hypertension	GAD Gene-Disease Associations	1.0	null
regulation of neuron projection development	GO Biological Process Annotations 2015	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.11019
Perturb_5280_KO_Ddx6_SRP137728	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.09769
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.864942
hydrocephaly	MGI Mouse Phenotype Associations 2023	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5738-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.953267
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.09083
Cortical microtubule cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.706
Perturb_13152_KO_Yme1l_SRP293109	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.90181
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_1978_KO_Sarm1_SRP332488	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.6034
Perturb_3364_KO_Adora2a_SRP306572	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.426
ZSCAN31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24585
Perturb_1918_KO_Irf5_SRP186268	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.78963
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.89137
BRD-K22789469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63319
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-NR3C1_targets_enrichment-Unnamed_6_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-0226-SM-4AT6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986374
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1809_KO_Irf5_SRP186268	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.83465
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3382-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIVF001-008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16116
Minodronic acid_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0115647
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970515
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.877
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
sublayer 6a of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02356
ITSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04008
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.85116
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06652
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57818
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
U-138MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
Perturb_15667_KD_Srsf7_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.43271
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.57045
Gastric	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.839223
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826478
BRD-A02799884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27277
SKNFI	CCLE Cell Line Gene Expression Profiles	1.0	1.3646
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Phenylephrine (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183664
PMC11544636-CCS3-18-e12047-s001.xlsx-Supplementary_Table_S2-Supplementary_Table_S2_554_differentially_expressed_genes_between_DOX_and_CTR_D0_in_A673pTERshEWS_FLI1_model_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_1018_Mut_Tspan2_SRP285017	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.45553
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
TGFBR2_knockout_296_GSE22989	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.37064
dilated brain ventricle	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75332
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72835
GTEX-RTLS-0926-SM-2TF5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17023
inner CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.907737
Perturb_7791_KD_EIF4A3_SRP049611	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.84839
microtubule-based process	GO Biological Process Annotations 2015	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72457
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21133
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05484
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00907
K562_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170176
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
KMS26	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7075
JUND_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1842_KO_Ifnar_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.95172
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1241
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20792
ELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31451
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
internal hemorrhage	MPO Gene-Phenotype Associations	1.0	null
CAMK2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87096
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
CAMKV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19743
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1548
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28911
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07528
Perturb_9113_OE_FOXO1A3_SRP188991	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.91284
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82663
BRD-K52956006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26079
BRD-A16119053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28634
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7769
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of r10BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17418
abnormal third ventricle morphology	MPO Gene-Phenotype Associations	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-POMQ-1226-SM-3P61F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971375
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
system development	GO Biological Process Annotations 2015	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal brain ependyma motile cilium physiology	MGI Mouse Phenotype Associations 2023	1.0	null
TMEM115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66298
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
catalytically	GeneRIF Biological Term Annotations	1.0	null
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30928
NRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33028
HCFC1	ENCODE Transcription Factor Targets	1.0	null
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16148
P31-FUJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21824
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36975
RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22181332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06132
orbital frontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.109
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_5141_KO_Rn7sk_ERP002405	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.43242
A549_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165739
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinary bladder	HPA Tissue Protein Expression Profiles	-1.0	-1.03065
GSE193334_1_v_0_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7730-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111903
Kleefstra syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
Perturb_1946_KO_Mettl14_SRP269254	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.40816
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EP300_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATG2-ATG18 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.667
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6632
Perturb_15671_KD_Cebpb_SRP160879	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.78052
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-5398-01A-02R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-GT-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_13271_KO_Msl2_SRP192624	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.98252
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Phagophore assembly site membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.028
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.58494
H3K9me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DYNC2I2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05314
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0926-SM-2HMIZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15248
regulation of cell differentiation	GO Biological Process Annotations 2015	1.0	null
UBXN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40773
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.1698
BRD-K15833017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05111
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_1123_KO_Myc_SRP168941	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.91999
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S95S-1326-SM-2XCDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17833
PAX5	ENCODE Transcription Factor Targets	1.0	null
ELF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040519
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00790166
regulation of nervous system development	GO Biological Process Annotations 2015	1.0	null
Perturb_13282_KO_Ythdf3_SRP254797	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.62204
testis	HPA Tissue Protein Expression Profiles	1.0	0.710832
regulation of stress-activated MAPK cascade	GO Biological Process Annotations 2023	1.0	null
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_15136_OE_Mfn2_SRP313676	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.40407
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Dacinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00920067
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
chr3_41971227_G_A_b38	GTEx eQTL 2025	1.0	2.50704
ELF5-23300383-T47D-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K63987422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26342
decreased body weight	MGI Mouse Phenotype Associations 2023	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6147-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64383
corpus callosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.969388
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.967492
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.325187
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.87054
SP4	ENCODE Transcription Factor Targets	1.0	null
PMC9041830-ppat.1010464.s009.xlsx-MAGeCK_MLE_output-STAT1-KO-Gene_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240291
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87134
MCF7_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149616
PMC7794364-41540_2020_161_MOESM3_ESM.xlsx-NSP_Unique_-_PPH2_predictions-Gene_Sym_SMAD9	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.707893
BRD-K05928130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3685
MCF7_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146853
chr3_41973618_C_T_b38	GTEx eQTL 2025	1.0	1.45517
DUT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44818
island of Calleja major	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00281
Multiple myeloma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.630103
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040811
K562_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156472
mantle zone of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12962
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF2	ENCODE Transcription Factor Targets	1.0	null
NFATC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09329
A549_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132513
BRD-K99116119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39924
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
KM12	CCLE Cell Line Gene Mutation Profiles	1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.43043
GSE88819_7_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
epididymis	HPA Tissue Protein Expression Profiles	-1.0	-1.03065
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.852
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.844332
Ciliary tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.635
SIN3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145589
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77534
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219586
A549_Tazemetostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158444
regulation of intracellular signal transduction	GO Biological Process Annotations 2025	1.0	null
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
VN(H5N1)_12hour_None_GSE37245	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.85493
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATF1	ENCODE Transcription Factor Targets	1.0	null
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T2IS-2226-SM-4DM65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08318
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.934827
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.863024
myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.225229
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF113A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33594
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8007
USF2	ENCODE Transcription Factor Targets	1.0	null
BRD-K04614055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16461
Perturb_14946_KD_Nmnat1_SRP102079	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.86047
Anxiety	DisGeNET Gene-Disease Associations	1.0	null
fallopian tube	HPA Tissue Protein Expression Profiles	-1.0	-1.03065
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Small Lymphocytic Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.41105
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.939104
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
r10 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17535
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
BRD-K88281646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34379
DETROIT562	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54103
IRF4_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MEG01	CCLE Cell Line Gene Mutation Profiles	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GOLGA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04362
protein modification process	GO Biological Process Annotations 2015	1.0	null
ISTMES2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.35463
GTEX-WEY5-0726-SM-4LMID	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856264
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68118416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09742
hsa-miR-4251	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
MCF7_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133617
K562_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193834
A375	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42976
SMZ1	DepMap CRISPR Gene Dependency	1.0	3.34421
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.053657
Perturb_8284_KD_CSTF2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.48973
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
LC1SQSF	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5303
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850121
TBX20-22328084-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20889
MCF7_Regorafenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014715
YD8	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13238_KO_Flcn_SRP126727	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.37878
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
TULP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.70303
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09152
BRD-K43298189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23572
SLC38A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55439
insulin	GAD Gene-Disease Associations	1.0	null
PMC3579516__F7	PFOCR Pathway Figure Associations 2023	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.15475
regulation of cell motility	GO Biological Process Annotations 2015	1.0	null
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5992
Cohen syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
CORL279	CCLE Cell Line Gene Expression Profiles	-1.0	-2.38513
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-0226-SM-48TBY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04437
BRD-K50479239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17605
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126127_2_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0789
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.078084
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58399
Perturb_13067_KO_Ube3d_SRP373803	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.5626
hypertension	GWASdb SNP-Disease Associations	1.0	1.74238
GSE111385_2_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH747	DepMap CRISPR Gene Dependency	1.0	2.36394
LU-65	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73971
PMC5059470-ncomms12992-s6.xlsx-CRS-NOCRS-Supplementary_Data_5_Integration_Frequency_in_cirrhotic_CRS_and_non-cirrhotic_no-CRS_Tumor_Samples_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
Ependymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.613
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898495
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101748_0_v_1_apela_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.67858
primary somatosensory cortex (area S1, areas 3,1,2)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13175
ELK1	ENCODE Transcription Factor Targets	1.0	null
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141632
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053162
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16185
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57634
MY-M12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45299
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11366
GSE157960_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.225473
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	149.082
BRD-K82922770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42479
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.946164
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chr3_41800637_C_T_b38	GTEx eQTL 2025	1.0	3.45084
MCF7_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144847
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20613
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73971
SNRNP200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24322
abnormality of eosinophils	GWASdb SNP-Phenotype Associations	1.0	0.834343
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-378g	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.284371
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5709-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MBD4	ENCODE Transcription Factor Targets	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-OOBJ-0526-SM-48TDK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9457
multiple myeloma	GWASdb SNP-Disease Associations	1.0	1.55738
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SPI1	ChEA Transcription Factor Targets	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Blood Pressure	DisGeNET Gene-Phenotype Associations	1.0	null
mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-QV31-1326-SM-2S1QE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895073
GTEX-WH7G-0326-SM-3NMBH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26292
abnormal ependyma morphology	MPO Gene-Phenotype Associations	1.0	null
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00201
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.898911
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.856991
single-organism process	GO Biological Process Annotations 2015	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041643
MCF7_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129517
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0698
canthaxanthin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04504
ZNF394	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22441
abnormal brain ependyma motile cilium morphology	MGI Mouse Phenotype Associations 2023	1.0	null
abnormal cilium morphology	MPO Gene-Phenotype Associations	1.0	null
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hypertension	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.58494
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hypotrichosis 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
GTEX-SUCS-1126-SM-4DM61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09581
abnormal brain morphology	MPO Gene-Phenotype Associations	1.0	null
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24996
binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36718
PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Basomedial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29073
Cortical amygdalar area, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07367
S-isopropylisothiourea	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15169
Pek	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.419
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	0.997124
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25891
BRD-K44344720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70832
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K37356599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19356
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164413
GTEX-SIU7-1826-SM-2XCE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1148
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-1726-SM-47JXP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0165
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
abnormality of skeletal morphology	GWASdb SNP-Phenotype Associations	1.0	0.062537
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PAX5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73159
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868988
km3	HPA Cell Line Gene Expression Profiles	-1.0	-1.20625
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.49091
TCF4-18268006-LS174T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
Flagella connector	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.765
Paraventricular hypothalamic nucleus, parvicellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51861
Perturb_3077_KO_Dct_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.82969
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36951
Membrane fusion priming complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.192
A549_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020684
laterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30437
FOXA1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.909674
Perturb_17247_KD_Brd2_SRP201499	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.6793
MOLP-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Response To Bronchodilator	DisGeNET Gene-Phenotype Associations	1.0	null
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01992
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850904
GTEX-PLZ4-2726-SM-3P61A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13363
lymph	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
paraventricular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8914
protein kinase activity	GO Molecular Function Annotations 2015	1.0	null
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863627
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26815
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.157423
K562_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0396157
DHX57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22001
BRD-K29728947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2239
K562_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303721
myocardial infarction	GWASdb SNP-Disease Associations	1.0	0.947208
Septohippocampal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33287
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32791
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_15644_KD_Cebpb_SRP160879	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.06201
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0728
Perturb_3742_KO_Cd274_SRP215305	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.80964
embryoday9.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07549
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Methylprednisolone succinate_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00937048
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58108
Ciliopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16584_KO_Mir2182_ERP130060	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.17409
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12559107-12035_2025_5221_MOESM1_ESM.xlsx-Supplment_Tab_3-Supplement_Tab_3_The_result_of_MR_analysis_for_SCZ_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84783
Perturb_3346_KO_Sox4_SRP094461	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.33879
PTEN_DN.V2	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00948
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053276
Perturb_4182_KO_Foxp1_SRP102696	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.49716
HCC1833	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8805
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84095
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24162
CEBPB_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
PMC9164515-5-12-22-eQTL_Supplemental_tables_ScientificReport.xlsx-Suppl_Table_8-Supplemental_Table_8_Significant_genes_in_MR_analyses_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS729	CCLE Cell Line Gene CNV Profiles	1.0	1.68591
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.49084
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K75967530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25103
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18987
Perturb_15850_KO_Etv5_SRP165224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.6592
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32893
NFYA	JASPAR Predicted Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01531
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
myofascial pain syndrome	GWASdb SNP-Disease Associations	1.0	0.794247
craniofacial phenotype	MPO Gene-Phenotype Associations	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960073
primary motor cortex (area M1, area 4)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.94937
BRD-K29655991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54943
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73688688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61201
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.939747
JUND_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism developmental process	GO Biological Process Annotations 2015	1.0	null
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163299
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54661
medial pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.34603
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71141540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22313
BRD-K70276322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79618
A549_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155592
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.828305
MET_knockout_251_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.29531
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.136691
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9825
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5158_KD_Zic3_SRP046299	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.8574
PRECLH	CCLE Cell Line Gene Expression Profiles	-1.0	-2.27955
Perturb_5292_KO_Dgcr8_SRP137730	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.45722
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.117
PMC7893038-41598_2021_83450_MOESM3_ESM.xlsx-DBP_Average_AMR-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	198.542
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21579
BRD-K94346447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04786
Perturb_11731_KD_Aurkb_SRP270617	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.37163
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ciliary plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.718
Multiple Myeloma	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1833_KO_Parp1_SRP254964	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.27801
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.064864
abnormal nervous system physiology	MPO Gene-Phenotype Associations	1.0	null
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.992137
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23517
Perturb_11891_KO_Arg2_SRP198795	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.40244
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6101
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH2291	CCLE Cell Line Gene Mutation Profiles	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051003
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03846
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02355
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79423
SNUC2A	CCLE Cell Line Gene Mutation Profiles	1.0	null
MCF7_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137626
BRD-K83254798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04251
Perturb_15823_KO_Ttc8_SRP247588	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.97025
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GEMIN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27286
PMC4521181-oncsis201520x8.pdf-10-ARHGAP35_ARHGAP35	Rummagene Transcription Factor Associations 2026	1.0	null
Situs inversus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
MCF7_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132222
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45897
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-2026-SM-3NB1R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94395
GTEX-WHWD-0326-SM-3LK6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23932
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
abnormal postnatal growth/weight/body size	MPO Gene-Phenotype Associations	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9008213__F2	PFOCR Pathway Figure Associations 2024	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PL4	DepMap CRISPR Gene Dependency	1.0	9.03825
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anatomical structure morphogenesis	GO Biological Process Annotations 2015	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168459
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
APTO-253_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0112347
gastrointestinal system disease	GWASdb SNP-Disease Associations	1.0	0.070045
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H345	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EZH2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959999
GTEX-N7MT-1926-SM-3LK5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87261
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-PN-A8MA-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8398_KD_Safb_SRP180874	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Perturb_12790_KO_Apoe_SRP124787	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.41301
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7941
r6 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0817
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPK5-0226-SM-3GAEV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2095
SMAD3-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00979949
abnormality of the biliary system	GWASdb SNP-Phenotype Associations	1.0	0.176908
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17338_KO_Mageb4_SRP259999	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.76385
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.885205
CREB1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH661	CCLE Cell Line Gene Expression Profiles	1.0	1.57089
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.888577
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Omegasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.313
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1195_KD_Mcm6_SRP293272	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.2135
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203695
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154536
hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.280796
Perturb_1848_KO_Ifnar_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.56822
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	1.94108
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4903-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC11462941-CAS-115-2947-s001.pdf-171-JDP2_JDP2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62911
NCI-H28	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.11641
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mantle zone of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.19354
abnormal ear physiology	MPO Gene-Phenotype Associations	1.0	null
Subcommissural organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
abnormal nose morphology	MPO Gene-Phenotype Associations	1.0	null
abnormal dorsal telencephalic commissure morphology	MPO Gene-Phenotype Associations	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular component morphogenesis	GO Biological Process Annotations 2015	1.0	null
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	3.26284
BRD-K10325583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03153
Anterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4389
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878389
NCIH2081	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_1006_KO_Bcl9l/Bcl9_SRP045828	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.83542
hematological neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.287328
BRD-K76609014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12167
D-566MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60857
lateral part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17418
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.086913
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.08112
abnormal internal nares morphology	MPO Gene-Phenotype Associations	1.0	null
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of plasma membrane bounded cell projection organization	GO Biological Process Annotations 2025	1.0	null
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4UY-1426-SM-4AD6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34007
BRD-K71857815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43098
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25196
intermediate stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09881
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.902547
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.860127
Perturb_13205_KO_Hdac3_ERP123505	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.17721
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPT6-0226-SM-4B65L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30134
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.21824
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.098891
CISD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92349
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13450_KD_Hnrnpk_SRP146257	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.85015
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.47719
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
ZR7530	CCLE Cell Line Gene Mutation Profiles	1.0	null
mRNA_NR0B1_19530134	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40139
Prostate adenocarcinoma_PRAD_TCGA-EJ-5507-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206575
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	116.704
TCF4	ChEA Transcription Factor Targets	1.0	null
Perturb_1841_KO_Ifnar_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.9629
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WFG7-0826-SM-3GIKU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29337
znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.057491
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1069
A-498 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
abnormal brain ventricular system morphology	MPO Gene-Phenotype Associations	1.0	null
PPFIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34732
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834176
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.886492
GTEX-NPJ8-0126-SM-2YUNR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892245
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149075_1_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DKKL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0584
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15061
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.942
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11299
Diastolic blood pressure	GWAS Catalog SNP-Phenotype Associations	1.0	0.483518
BRD-K89514545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16347
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.05576
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846885
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ATPAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18833
BRD-K67328514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10319
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1271_KO_Adar_SRP132963	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.86517
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hydroencephaly	MPO Gene-Phenotype Associations	1.0	null
MCF7_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011498
A549_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155447
LB373-MEL-D	GDSC Cell Line Gene Expression Profiles	-1.0	-2.2663
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03238
dorsal part of JcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.39514
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0677
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5458-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12109
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9110_OE_FOXO1A3_SRP188991	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.35999
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO800	DepMap CRISPR Gene Dependency	1.0	6.4521
abnormality of the systemic arterial tree	GWASdb SNP-Phenotype Associations	1.0	0.28617
mantle zone of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30623
YY1	ENCODE Transcription Factor Targets	1.0	null
BRD-K35098144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14467
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944528
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56037
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98504
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.61154
UO31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41298
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04476
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6443
MCF7_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134894
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QMR6-1926-SM-32PL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32174
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10811
BRD-K71537579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52933
MCF7_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160174
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828038
BA-39-OX47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258269
dilated lateral ventricles	MPO Gene-Phenotype Associations	1.0	null
Perturb_10988_KO_Gnpda2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.48087
HCC1419	COSMIC Cell Line Gene Mutation Profiles	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-2.09621
PMC6344081-elife-40364-supp8.xlsx-PLZF-kd_2d_Diff_Vs_Ctrl_2d-diff-Symbol_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
Superior colliculus, motor related, intermediate gray layer, sublayer c	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04736
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MED8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33999
A549_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167962
regulation of neuron migration	GO Biological Process Annotations 2015	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10794847-mmc6.xlsx-PIAS1_KD_down-Table_S5_Genes_differentially_expressed_with_PIAS1_knockdown_in_keratinocytes_cultured_in_the_differentiation_condition_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SNU8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79924
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4912-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145639_7_v_6_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Nephron	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32855
KDM2B-26808549-CHIP-SEQ-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Sarcoma_SARC_TCGA-3B-A9HR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.654
Perturb_3168_OE_Rbfox2_SRP186301	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.90811
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217109
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.595285
Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855988
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUW1-0526-SM-4BOP3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99774
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.552815
ESR1_ECC-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of neurogenesis	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25U-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Precommissural nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4019
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897115
GSE166914_1_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr3_41954644_T_C_b38	GTEx eQTL 2025	1.0	2.19414
SIRT6	ENCODE Transcription Factor Targets	1.0	null
BRD-K86764949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05824
MCF7_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182954
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
GSE233679_12_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73C-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3653
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5397-01A-01R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ESR1	ENCODE Transcription Factor Targets	1.0	null
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intermediodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.27861
ETS1	ENCODE Transcription Factor Targets	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5203
BRCA1	ENCODE Transcription Factor Targets	1.0	null
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CS1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A427	GDSC Cell Line Gene Expression Profiles	1.0	1.9168
K562_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162596
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE75976_3_v_6_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT5A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Loeys-Dietz syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6014
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84695
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	1.0	1.15252
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inner CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09191
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051885
TOV21G	CCLE Cell Line Gene Mutation Profiles	1.0	null
dilated third ventricle	MPO Gene-Phenotype Associations	1.0	null
GTEX-T6MN-0826-SM-32PM4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84067
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967987
A549_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162096
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6483
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.13869
Perturb_5883_KD_Ift88_SRP188845	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.78865
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
immune system disease	GWASdb SNP-Disease Associations	1.0	0.062251
BRD-K11741103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13948
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228336
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00169
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.927578
Lung adenocarcinoma_LUAD_TCGA-75-7030-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
immune system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.967492
THAP1	ENCODE Transcription Factor Targets	1.0	null
COLO-684	GDSC Cell Line Gene Expression Profiles	1.0	1.60384
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10598
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0587
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43747
dilated lateral ventricle	MGI Mouse Phenotype Associations 2023	1.0	null
HCT15	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.55647
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.3359
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14713
LNCAPCLONEFGC	CCLE Cell Line Gene Mutation Profiles	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.81262
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40486
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44045
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01715
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2085	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39247
GSE201454_1_v_4_ftcd_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
kidney disease	GWASdb SNP-Disease Associations	1.0	0.863933
Perturb_5206_KO_Dgcr8_SRP137729	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.4955
periventricular stratum of p1B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24109
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74888
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.999044
Cvt vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.936
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3	ChEA Transcription Factor Targets	1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40245
Schizophrenia_CNS - Brain - Cerebellum (MMHCC)_GSE4036	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.55889
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15768_OE_Pcbp2_SRP218930	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.8297
Phagophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.579
chr3_41713867_T_C_b38	GTEx eQTL 2025	1.0	1.1867
PMC9314667-Table_1.xlsx-Regulons-SOX10_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_17318_KO_Ddx5_SRP284247	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.1899
Perturb_13449_KD_Hnrnpk_SRP146257	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.65879
K562_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021021
Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TB-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
DMRT1	ChEA Transcription Factor Targets	1.0	null
regulation of phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1117
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17343_KO_Mageb4_SRP259999	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.71874
BRD-K48670593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0165
SK-OV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32855
APP	Pathway Commons Protein-Protein Interactions	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
IRF3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
PAX5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10291819-13287_2023_3380_MOESM10_ESM.pdf-29-ZNF345_ZNF345	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210885_0_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38681
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
abnormal cardiovascular system physiology	MPO Gene-Phenotype Associations	1.0	null
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.17339
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCUBM	DepMap CRISPR Gene Dependency	1.0	3.26624
intraventricular hemorrhage	MPO Gene-Phenotype Associations	1.0	null
Field CA1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33929
Perturb_9412_KD_Pcbp1/Platr18_SRP251371	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.82074
GTEX-S4UY-0726-SM-4AD6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00606
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053352
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.070591
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.284798
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38214
crizotinib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0123516
ACHE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02813
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22789
Perturb_4136_KD_Grin1_SRP106749	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.49605
septal nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.93141
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.939942
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12701
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4W0-05A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TADA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08009
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.156342
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.67991
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20647
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10599_OE_Vcp_SRP214099	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.90678
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.832398
PMC7866901__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4864-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03752
mRNA_EP400_22196727	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
diastolic blood pressure	GAD Gene-Disease Associations	1.0	null
Perturb_1866_KO_Ifnar_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.5224
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lipoic acid_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164086
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147791
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30907
MCF7_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197179
Perturb_16551_KO_Ahr/Rag1_SRP159568	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.58623
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Pellicular membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.937
K562_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018016
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A907-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M7-01A-12R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181311
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.6915
Perturb_3083_KO_Elmo3_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.3058
GTEX-X8HC-1526-SM-46MWD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841186
Posterior polar cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
AMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20571
SP in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34227
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S341-1126-SM-4AD6T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43953
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pretectal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08252
GBX2	ChEA Transcription Factor Targets	1.0	null
abnormal choroid plexus morphology	MPO Gene-Phenotype Associations	1.0	null
malformation of the heart and great vessels	GWASdb SNP-Phenotype Associations	1.0	0.182998
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5689
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250243
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
K562_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152791
BRD-K41731469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19868
abnormal brain ependyma motile cilium morphology	MPO Gene-Phenotype Associations	1.0	null
PC-3_[JPC-3]	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-N-SH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDQP1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.89167
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.51288
Perturb_15752_KO_Ezh2_SRP096837	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.882854
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1232
Monoclonal Gammopathy of Undetermined Significance	HuGE Navigator Gene-Phenotype Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7713-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37759
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autophagosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.928
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MB-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32745
hsa-miR-4692	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Perturb_9556_KO_IKKa_SRP111864	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90711
MCF7_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136822
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02418
EP300_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
significance	GeneRIF Biological Term Annotations	1.0	null
INO80E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79429
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09298
FOSL2	ENCODE Transcription Factor Targets	1.0	null
cell projection morphogenesis	GO Biological Process Annotations 2015	1.0	null
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K21620541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27619
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09096
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00624
Perturb_14762_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.27488
Phragmoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.245
BRD-K54198678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.159
Perturb_12072_OE|KD_Tfap2a|Tgfb1_SRP067296	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.8798
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1256
STIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60783
Lung adenocarcinoma_LUAD_TCGA-49-6745-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLI1	ChEA Transcription Factor Targets	1.0	null
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
regulation of neuron migration	GO Biological Process Annotations 2025	1.0	null
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38637
MCF7_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151045
pregnenolone-2497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.60885
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12499
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	1.0	0.867942
A549_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125359
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249126
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67586245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20946
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fetal_Intestine_Small	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.18367
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of neuron projection development	GO Biological Process Annotations 2025	1.0	null
Sarcoma_SARC_TCGA-FX-A76Y-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
appendix	HPA Tissue Protein Expression Profiles	-1.0	-1.03065
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1049
BRD-K19567079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00913
dorsal juxtacommissural pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.41112
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.934827
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
coronary artery disease	GWASdb SNP-Disease Associations	1.0	1.47287
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08375
TE-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61797
Perturb_13179_KO_Mof_SRP060636	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.92221
STAT3	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63047
GTEX-REY6-2126-SM-48FD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00179
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uvula (IX), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05961
Major island of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91416
fallopian tube	HPA Tissue Gene Expression Profiles	1.0	2.12284
Dilated cardiomyopathy 1E	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.716
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34502
GTEX-X4EP-0326-SM-3P5Z6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3939
GSE143316_0_v_6_somatostatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
microtubule-based movement	GO Biological Process Annotations 2015	1.0	null
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67612
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_16357_OE_Ant1_SRP217849	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.04463
cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.405305
abnormal telencephalon morphology	MPO Gene-Phenotype Associations	1.0	null
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.259
K562_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153563
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4248
BRD-K97052218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36063
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90009
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Habenular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
BRD-K97064059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43811
schizophrenia	GeneRIF Biological Term Annotations	1.0	null
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1804
POLR2AphosphoS5_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10714175-mmc2.xlsx-KD_Gene_list-Supplemental_Table_3_FAM13B_knockdown_mediated_changes_in_gene_expression_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34858602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18452
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4292
JM1	DepMap CRISPR Gene Dependency	1.0	2.81756
FOXA1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_15673_KD_Hnrnpk_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.07525
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	1.0	0.710832
GTEX-S341-1326-SM-4AD72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37671
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826411
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947549
abnormal maxillary sinus morphology	MPO Gene-Phenotype Associations	1.0	null
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Blood pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2301
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.89847
H3K36me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE-11	GDSC Cell Line Gene Expression Profiles	1.0	2.74511
Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5061_KD_Cnot10_SRP251834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.57474
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60956
18927307-tableS2	GeneSigDB Published Gene Signatures	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Coronary Heart Disease	DisGeNET Gene-Disease Associations	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14523
GTEX-UPIC-1526-SM-4IHLU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15146
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FSCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28609
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147056_3_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864466
Lymph	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9136
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35861
MCF7_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0097612
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.58494
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.60102
inactive	GeneRIF Biological Term Annotations	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040012
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.857943
Perturb_3081_KO_Dock11_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.93953
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.88533
Perturb_12917_KO_Cbfb_SRP214434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.4888
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
Somatic embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.116
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.830034
Perturb_11065_KO_Mettl3_SRP363782	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.42317
CTCF	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K24263752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61364
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0155
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
protein phosphorylation	GO Biological Process Annotations 2015	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32408
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04608
PMC4686761-ncomms10068-s3.xlsx-S2E-MSC_up_specific-Supplementary_Data_2E_-_expression_of_up-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10730_KO_Nr1h4_SRP299252	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.7417
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23009
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A69950438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04033
MCF7_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136635
MCF7_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158753
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57795803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04379
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alcohol dependence	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
artery disease	GWASdb SNP-Disease Associations	1.0	0.399074
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
IZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04369
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27769
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.92844
GTEX-RU72-2626-SM-4GIE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29913
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.844799
Lung squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863206
GSE111660_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WL46-0726-SM-3LK5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13386
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
12471243-TableS2	GeneSigDB Published Gene Signatures	1.0	null
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
T47D	CCLE Cell Line Gene CNV Profiles	1.0	1.60465
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3849_KD_TGM2_SRP194250	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.65761
Perturb_16919_KD_H19_SRP151268	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.77004
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KMM1	CCLE Cell Line Gene Expression Profiles	1.0	2.97399
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01117
Perturb_18396_KO_Gpnmb_SRP298610	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.31496
abnormal survival	MPO Gene-Phenotype Associations	1.0	null
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S32W-1526-SM-4AD6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48712
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5431
BRD-K81261525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07228
MCF7_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00952569
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3403_KO_Cbfb_SRP214434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE233679_6_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U412-0826-SM-3DB9K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02772
PMC10361959-41419_2023_5985_MOESM1_ESM.pdf-185-THRB-AS1_THRB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3371315-NIHMS350140-supplement-9.xls-MCF7-T47D-SK-453_Up_MCF7-T47D_x-Supplementary_Table_2_ER-positive_FOXA1_signature_Genes_increased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93486
496100388_HIP_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.52296
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of PThE	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2179
BRD-K38274933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44512
SOX9	ChEA Transcription Factor Targets	1.0	null
BRD-A23345137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39291
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43005
Body Mass Index	DisGeNET Gene-Phenotype Associations	1.0	null
P300-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57562
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2102
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2029	CCLE Cell Line Gene CNV Profiles	1.0	1.40808
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9668
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.854047
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897115
abnormal immune system physiology	MPO Gene-Phenotype Associations	1.0	null
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04124
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38763
MEG-01	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PAX5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80929
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7036
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GI-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9158
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014866
hsa-miR-4514	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the skull	GWASdb SNP-Phenotype Associations	1.0	0.341781
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0625
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61697
K562_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158553
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05539
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
increased inflammatory response	MPO Gene-Phenotype Associations	1.0	null
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
BRD-K13927197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22611
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12554
Perturb_5813_Mut_U2af1_SRP266807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.80982
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STOCK1N-28457-6864	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
COLO849	CCLE Cell Line Gene CNV Profiles	1.0	1.62046
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
BRD-K27653895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20801
GSE130081,GSE130082_4_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Abdominal aortic aneurysm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
Perturb_4952_KO_Zbtb2_ERP125292	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.54796
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VDR	ChEA Transcription Factor Targets	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.37875
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32266
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00271
C-Reactive Protein	dbGAP Gene-Trait Associations	1.0	0.101028
A549_Azacitidine_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124196
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.7975
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KK-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34604
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MN-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3313-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_ITSA-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132303
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A6K9-06A-41R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16610_KO_Phb_SRP229743	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-K44167510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32735
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149075_8_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04144
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31833
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51139
H3K4me1_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Gene_Name_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4201_KO_Scn1a_SRP133962	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.36942
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.962537
Perturb_12778_KO_C9orf72_SRP301422	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.42995
Prostate adenocarcinoma_PRAD_TCGA-KK-A8ID-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_1845_KO_Nos2_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.62819
BRD-K90349877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13418
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.678363
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23929
RUNX3	ENCODE Transcription Factor Targets	1.0	null
HOS	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50709
Perturb_13230_OE_Rnaseh1_SRP056871	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Intelligence	DisGeNET Gene-Phenotype Associations	1.0	null
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	2.00338
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226702
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77653
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05858
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
769-P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25731
Aorta thoracica	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16369
GTEX-TMMY-1926-SM-4DXUU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10608
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37772
Perturb_8369_KO_Mlxipl_SRP148418	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.24678
Anterior cingulate area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05085
REST	ENCODE Transcription Factor Targets	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14933
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854311
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_10696_KD_Gls2_SRP326675	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.74857
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5982-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lung adenocarcinoma_LUAD_TCGA-99-8025-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154074_5_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
periventricular stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.23073
orbital frontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.933362
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892514
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.99646
AN3CA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.83
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.869738
Perturb_15275_OE_Foxa1_SRP189075	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.30497
PA-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.69869
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
SOGA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19548
BCPAP	GDSC Cell Line Gene Expression Profiles	1.0	1.55373
regulation of mapk cascade	GO Biological Process Annotations 2015	1.0	null
DMS273	CCLE Cell Line Gene Mutation Profiles	1.0	null
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60055
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047478
Hodgkin Disease	DisGeNET Gene-Disease Associations	1.0	null
BRD-K99971319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.495
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_10927_KO_Mettl3_SRP363782	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.75382
daudi	HPA Cell Line Gene Expression Profiles	1.0	1.51345
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824803
CW2	CCLE Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310208
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	155.878
multiple myeloma	GWASdb SNP-Phenotype Associations	1.0	1.41863
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K24076516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72561
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_5_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.01097
Perturb_3064_KO_48J19Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.57661
NR2E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16289
E2F4_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48894
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1245
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10303
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.840394
Blood pressure traits (multi-trait analysis)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1
BRD-K35789946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01008
macrophage	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.95155
respiratory system phenotype	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ELK1-22589737-MCF10A-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEx Thyroid 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	6.72854
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4269
Lateral habenula	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08779
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.88512
Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12606
Brain Lower Grade Glioma_LGG_TCGA-DU-6404-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K46149455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2971
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0314258
COPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12814
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.093
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06372
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thoracic aortic aneurysm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.48
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ribostamycin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0024
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
Piccolo NuA4 histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.645
MCF7_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150206
Perturb_14649_KD_Paf1_SRP297013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.0191
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98504
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37094
skin_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.935697
FOXA1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5679-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98479
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
movement of cell or subcellular component	GO Biological Process Annotations 2015	1.0	null
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.88046
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the coronary arteries	GWASdb SNP-Phenotype Associations	1.0	0.477068
Agenesis	DisGeNET Gene-Disease Associations	1.0	null
Perturb_16086_KO_Bap1_SRP270239	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.30016
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052188
Perturb_1852_KO_Nox2_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.65464
BRD-A39506880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42064
HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10123
posterior (caudal) superior temporal cortex (area 22c)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46939
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920141
ELK1-22589737-MCF10A-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SNU1076	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46239
Oogenesis phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K06896230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27713
KATOIII	COSMIC Cell Line Gene CNV Profiles	1.0	2.15402
Obesity	DisGeNET Gene-Disease Associations	1.0	null
protein kinase C deactivation	GO Biological Process Annotations 2025	1.0	null
RAVER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27185
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202281
A549_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137036
OVTOKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
chr3_41926401_C_A_b38	GTEx eQTL 2025	1.0	3.8484
recurrent infections	GWASdb SNP-Phenotype Associations	1.0	0.298381
chr3_41840309_T_C_b38	GTEx eQTL 2025	1.0	6.48224
MCF7_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232852
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25397
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7579-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73495
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ciliated cell_Trachea_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Tectum mesencephali	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117046
GTEX-RU1J-1026-SM-46MUR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14464
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Holoprosencephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.547
MOLT4	BioGPS Cell Line Gene Expression Profiles	1.0	1.55887
GTEX-VUSG-0726-SM-3GIK1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07536
BRD-K80921954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1518
transferase activity	GO Molecular Function Annotations 2015	1.0	null
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.830905
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241407
abnormality of the abdominal organs	GWASdb SNP-Phenotype Associations	1.0	0.05307
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01237500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62794
A549_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215478
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4433
BRD-K90697690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36254
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE211963_0_v_3_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4776
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05162
MCF7_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223168
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11847
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.72865
CORL95	CCLE Cell Line Gene Expression Profiles	-1.0	-2.12405
developmental process	GO Biological Process Annotations 2015	1.0	null
Perturb_2235_KO_Irf8_SRP270893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.68263
dorsal part of CoP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16583
MCF7_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016038
HS944T	DepMap CRISPR Gene Dependency	1.0	2.07676
LCLC-103H	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE128099,GSE128159_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-W5X1-0526-SM-3GILH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873388
K562_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214472
SNU387	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77008
NCIH2172	CCLE Cell Line Gene Mutation Profiles	1.0	null
vascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.58494
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
decreased corpus callosum size	MPO Gene-Phenotype Associations	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16972
thymus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.49948
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52979
CD4_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.992562
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64822
SIAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06682
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49513
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01086
MCF7_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014764
ZNF263	ENCODE Transcription Factor Targets	1.0	null
Esophagus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.07949
tiotropium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53647
BRD-K84090286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04876
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.856086
first	GeneRIF Biological Term Annotations	1.0	null
Manchette	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.625
PMC7893038-41598_2021_83450_MOESM3_ESM.xlsx-DBP_Average_TRANS-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MT-0126-SM-2D7VT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925264
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12097
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87306
NCIH650	CCLE Cell Line Gene Mutation Profiles	1.0	null
chr3_41913095_G_A_b38	GTEx eQTL 2025	1.0	2.94041
FU-OV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SCC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_3402_KO_Cbfb_SRP214434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.17318
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BCL11A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87720600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32522
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19211
SP1	ENCODE Transcription Factor Targets	1.0	null
ONCODG1	CCLE Cell Line Gene Expression Profiles	1.0	1.90267
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040154
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.988987
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small stomach	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_3122_KO_Slc6a14_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.76703
GSE168797_2_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS20	CCLE Cell Line Gene Expression Profiles	1.0	2.40415
GTEX-PSDG-0326-SM-48TCP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824208
Kidney renal clear cell carcinoma_KIRC_TCGA-GK-A6C7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Te	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
A549_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138581
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.97357
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.54406
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
susceptibility	GeneRIF Biological Term Annotations	1.0	null
MCF7_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143341
PMC6520398-41467_2019_10148_MOESM11_ESM.xls-FigS1a-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of immune system physiology	GWASdb SNP-Phenotype Associations	1.0	0.182628
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.985758
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WQUQ-1326-SM-3MJFF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27531
GTEX-RM2N-0426-SM-2TF4T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03152
MCF7_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122572
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
ESR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15088_KO_Yap1/Wwtr1_SRP303521	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.3924
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal brain ventricle morphology	MPO Gene-Phenotype Associations	1.0	null
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78223
Multiple Myeloma	dbGAP Gene-Trait Associations	1.0	0.731179
Perturb_5542_KO|KD_Fh1|Foxa2_ERP138019	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.2151
r6 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09387
Perturb_17317_KO_Ddx5_SRP284247	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.64101
Perturb_2376_KD_Cdk8_SRP292215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.8945
regulation of G protein-coupled receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-KDM5B-Unnamed_5_KDM5B	Rummagene Transcription Factor Associations 2026	1.0	null
EB-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178329
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14616
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Quisinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011491
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Axoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.719
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0728
Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5966
MCF7_Belinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197937
Perturb_17645_KD_EloB_SRP072351	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.88534
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34501072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12064
GTEX-PWOO-2026-SM-48TDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15406
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	1.0	null
c-reactive protein	GAD Gene-Disease Associations	1.0	null
decreased corpus callosum size	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NFYA	ENCODE Transcription Factor Targets	1.0	null
BRD-K87930002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16568
abnormality of granulocytes	GWASdb SNP-Phenotype Associations	1.0	0.322127
SMAD4-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056096
GSE210885_5_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSN1	CCLE Cell Line Gene CNV Profiles	1.0	1.44532
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
Systolic Pressure	DisGeNET Gene-Phenotype Associations	1.0	null
Armadillo-type fold	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.842609
Perturb_15767_OE_Msi1_SRP218930	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.717
TACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14365
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.39
SH-EP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.73416
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67879
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829753
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.09156
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38244121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79656
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837848
GSE233679_12_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926374
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19654
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.710832
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3R2-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBK1_druginhibition_188_GSE53658	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.42004
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8114-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Major depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MU-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	182.785
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K27782186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37304
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4433
GSE84462,GSE84762_0_v_7_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_5253_KD_Snd1_SRP311785	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8261-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of neuron differentiation	GO Biological Process Annotations 2015	1.0	null
BRD-K71575663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18801
Perturb_13212_KO_Lima1_ERP128082	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.58385
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96744
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
GTEX-UJMC-0326-SM-3GAE2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873952
BRD-K06956443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98975
GSE127790_13_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K24084946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09867
RBBP5	ENCODE Transcription Factor Targets	1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4621-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12916_KO_Cbfb_SRP214434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.5584
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_EA-SYMBOL_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04371
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.890362
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Phosphatidylinositol 3-kinase complex, class III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.382
Basal body patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.009
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47209
WSUDLCL2	CCLE Cell Line Gene Expression Profiles	1.0	1.52859
MALME 3M	BioGPS Cell Line Gene Expression Profiles	1.0	1.01142
regulation of developmental process	GO Biological Process Annotations 2015	1.0	null
Perturb_3068_KO_Apof_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.63005
COLO818	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47977
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10361_KO_Arid5a_SRP288358	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Lacunar stroke	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MRPL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37382
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A8AZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119384
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38097136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26329
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.227725
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29H-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW480	CCLE Cell Line Gene Expression Profiles	1.0	2.54507
regulation of cellular component organization	GO Biological Process Annotations 2015	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36995
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24914
Perturb_15476_OE_MYC_SRP218384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.26814
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989613
JUND	ENCODE Transcription Factor Targets	1.0	null
SP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02449
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_MAP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
MCF7_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154282
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-2426-SM-3MJHL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45463
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
regulation of protein kinase c signaling	GO Biological Process Annotations 2015	1.0	null
Perturb_1806_KO_Trif_SRP377807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.79382
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20183
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF4-18268006-LS174T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1049
BRD-K34009110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28123
SERP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82434
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endopiriform nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24784
GTEX-XGQ4-0926-SM-4AT4U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919523
PMC7687904-41598_2020_75770_MOESM1_ESM.xlsx-SP2-ENSGID_SP2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_15117_KD_Rtn4_SRP278924	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
NFATC1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3419980-leu201249x4.xls-H3K9Ac-RUNX1ETO_peaks_2fold-All_gene_regions_overlapping_with_RUNX1-ETO_peaks_changing_histone_acetylation_more_than_2-fold_after_knock-down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227643
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36517
TEAD4	ChEA Transcription Factor Targets	1.0	null
A549_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181736
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20333
H2BK15ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.32015
chr3_41775181_G_C_b38	GTEx eQTL 2025	1.0	2.98723
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07423
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160522
abnormality of the myocardium	GWASdb SNP-Phenotype Associations	1.0	0.742364
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.894926
Prostate adenocarcinoma_PRAD_TCGA-EJ-5524-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148252_7_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.2744
CREBBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.28833
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
GATA1_G1E-ER4_mm9_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.02776
abnormal respiratory epithelium morphology	MPO Gene-Phenotype Associations	1.0	null
ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.638065
ZFP36L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20762
SIX5	ENCODE Transcription Factor Targets	1.0	null
ECC12	CCLE Cell Line Gene CNV Profiles	1.0	2.53254
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1357
BRD-K52232548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13294
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04049
SMAD4-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BICR31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89662
Acute Aortic Dissection	DisGeNET Gene-Disease Associations	1.0	null
GTEX-V1D1-0626-SM-4JBHN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859532
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-1126-SM-2XCAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95261
Hemoglobin levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
MAFK	ENCODE Transcription Factor Targets	1.0	null
BRD-K90702747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33203
Perturb_14268_OE_Mir451a_SRP305305	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Perturb_4990_KO_Ctnnb1_SRP240867	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
HT1376	CCLE Cell Line Gene Expression Profiles	1.0	1.68322
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87306
LEF1-29337183-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.76234
GSE88819_5_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
D-247MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42481
cognitive disorder	GWASdb SNP-Disease Associations	1.0	1.20685
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG5-0826-SM-2I5GF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83945
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.54565
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46211
Rimonabant (Hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0189754
GSE96777,GSE96778_3_v_2_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF322	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31051
Lung adenocarcinoma_LUAD_TCGA-44-7659-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1872_KO_Ifnar_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.3856
Axonemal microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.751
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145553
MTA3	ENCODE Transcription Factor Targets	1.0	null
KASUMI-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.131634
Perturb_12791_KO_Trem2_SRP124787	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.7136
medial part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10303
Gut microbiota (functional units)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
intracranial hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.642221
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
gliclazide-2870	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.85836
YKT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51225
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23172
SEC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23609
BRD-K81537454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26497
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SETDB1	ENCODE Transcription Factor Targets	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7C-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_KO_TESTES_627_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.966055
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80023
BRD-K71210410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35011
Benztropine (mesylate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00899884
UBC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50042
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7397
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158932
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114864
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49745983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03802
Essential hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
Acute Myeloid Leukemia_LAML_TCGA-AB-2975-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J6-01A-31R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10013
BRD-K77871059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05947
TGBC1TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.32099
growth/size/body phenotype	MPO Gene-Phenotype Associations	1.0	null
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	1.0	1.02011
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164068
Supramammillary nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.05506
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
(R)-Verapamil (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0202946
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292109
MCF7_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125284
Perturb_5483_KD_Ctnnb1_SRP130920	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.92542
GSE126345_9_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164782
WHSC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-PWOO-1526-SM-48TCK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.48927
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17389037-Tab2	GeneSigDB Published Gene Signatures	1.0	null
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.904464
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40442
mfe296	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42514
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.53702
K562_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169451
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7260947-pnas.1912355117.sd02.xlsx-Sheet1-1185_common_genes_in_D_E_genes_KD_and_AcAPE1_ACOGG1_G4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
UDSCC2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-1026-SM-3NMDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993997
abnormal craniofacial morphology	MPO Gene-Phenotype Associations	1.0	null
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5887-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62931
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.103555
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OE-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SF126	DepMap CRISPR Gene Dependency	1.0	2.08421
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21371
KDM5A	ENCODE Transcription Factor Targets	1.0	null
LIPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01421
K562_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0274393
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28728
FTC238	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66641
TEAD4	ENCODE Transcription Factor Targets	1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_18281_KO_Ndp_SRP182592	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
EP300_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
recurrent viral infections	GWASdb SNP-Phenotype Associations	1.0	0.622665
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07464
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141386
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92300676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08709
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0138
Lung squamous cell carcinoma_LUSC_TCGA-90-7767-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4709_KO_Hesx1_ERP023509	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.6006
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TEAD2_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162356
Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NM-01A-21R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4811_KO_Mapk1_ERP004375	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.11337
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05051664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31749
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040378
MCF7_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0076485
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.990455
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_3_AP1_Up_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56548
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
bed nucleus of the stria terminalis, laterocentral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48082
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123836_2_v_3_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC2_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5B-Up_H3K4me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ATP6V1G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69512
JOSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08482
abnormal motile cilium morphology	MPO Gene-Phenotype Associations	1.0	null
DMS-273	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
MYOG	ENCODE Transcription Factor Targets	1.0	null
NFYB	ENCODE Transcription Factor Targets	1.0	null
KYSE270	CCLE Cell Line Gene CNV Profiles	-1.0	-2.33497
BRD-K55053106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96657
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79519
MCF7_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145556
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5021
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	128.786
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
ELF5	ChEA Transcription Factor Targets	1.0	null
PMC9170110-pgen.1010161.s047.xlsx-DBP_DEP-nearestGene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
EW-11	GDSC Cell Line Gene Expression Profiles	-1.0	-1.41852
Perturb_13583_KD_Cnn3_SRP300802	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.37539
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
salivary gland	HPA Tissue Gene Expression Profiles	-1.0	-0.842723
Kidney renal papillary cell carcinoma_KIRP_TCGA-UN-AAZ9-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136664
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05225
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45947503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4547
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32793
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25188
Pulse pressure x alcohol consumption interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.70458
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181525
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00068
MZ in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.842014
Perturb_7096_KO_Eif2ak3_SRP271084	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.56655
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
IST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20519
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03557
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.48199
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K87277021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60529
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63531
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08671
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00432
Perturb_5482_KD_Ctnnb1_SRP130920	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K08504955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01934
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anteroventral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889795
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	3.06081
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835623
PMC12443547-DataSheet5.pdf-3-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5895
RERFLCMS	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WWYW-0926-SM-3NB2Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876996
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62079
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.06844
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20857
Perturb_1808_KO_Arhgef2_SRP186268	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.36289
Perturb_8403_KD_Safb_SRP234723	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-QEG4-0526-SM-48TZD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955492
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.826638
thyroid gland	HPA Tissue Protein Expression Profiles	1.0	0.710832
BRD-A37056613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70777
9+0 non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.281
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3080_KO_Dnase1l2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.29705
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
Perturb_15630_KD_Ctnnb1_SRP130920	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.12209
LMAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45262
STAT3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCAIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19842
epithelial cilium movement	GO Biological Process Annotations 2015	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.128488
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	58.8418
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NB1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RVPV-1226-SM-2TF73	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826126
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76224440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03647
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE187006_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HEC108	CCLE Cell Line Gene Mutation Profiles	1.0	null
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.24869
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A24436948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14901
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14418
SREBF1	ENCODE Transcription Factor Targets	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fetal Kidney	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.871661
EBF1	ENCODE Transcription Factor Targets	1.0	null
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cytoskeletal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043466
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3335
Monoclonal Gammopathy Of Undetermined Significance	DisGeNET Gene-Disease Associations	1.0	null
Immunoglobulin light chain (AL) amyloidosis	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906883
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
skbr3	HPA Cell Line Gene Expression Profiles	-1.0	-0.968419
H4K91ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-P78B-2226-SM-3P5ZZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87453
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cerebrovascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.182
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.836511
corpus callosum development	GO Biological Process Annotations 2015	1.0	null
A549_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246134
oral mucosa	HPA Tissue Protein Expression Profiles	-1.0	-1.03065
Hypertension	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K85908443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05492
BRD-K12336887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00754
Perturb_13298_OE_Pik3ca_SRP173204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.96892
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.7028
Prostate adenocarcinoma_PRAD_TCGA-EJ-5510-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsal preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24784
GTEX-T2IS-0011-R2A-SM-32QPF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02896
Perturb_13580_KD_Keap1_SRP274135	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.6908
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE159937_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCK81	CCLE Cell Line Gene Mutation Profiles	1.0	null
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0300674
abnormal respiratory motile cilium morphology	MPO Gene-Phenotype Associations	1.0	null
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1514
GDAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1673
Loeys-Dietz syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
ear inflammation	MPO Gene-Phenotype Associations	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A264-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6513-01A-21R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138542
NCIH1184	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37562
TAL1_megakaryocyte_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	1.31232
MCF7_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108122
ETS1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EP300_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164094
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70107
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
Perturb_5004_KO_Rinf_SRP200002	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.78803
Perturb_5872_KD_Nudt21_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.7551
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.998868
CAMA1	CCLE Cell Line Gene Expression Profiles	1.0	1.46598
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73814
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
predicted	GeneRIF Biological Term Annotations	1.0	null
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	0.710832
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054281
SU-DHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09715
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SREBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SN8G-1526-SM-4DM79	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17426
chr3_41820740_C_A_b38	GTEx eQTL 2025	1.0	1.4
E2F6	ENCODE Transcription Factor Targets	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_1277_KO_Ptpn2_SRP108032	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.9021
Neoplasms	CTD Gene-Disease Associations	1.0	1.1908
GTEX-TMMY-0726-SM-33HBE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918542
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
A549_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131608
regulation of multicellular organismal development	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1	ENCODE Transcription Factor Targets	1.0	null
ESR1-22446102-UTERUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76639
Prostate adenocarcinoma_PRAD_TCGA-HC-7231-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.32998
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.961069
clidinium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25218
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09686
GTEX-OHPK-2026-SM-3MJH7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995778
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058051
PMC4051124-1471-2164-15-256-S15.XLSX-WES_IPD-RBCK1_1-Target_RBCK1	Rummagene Transcription Factor Associations 2026	1.0	null
GBX2-23144817-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of cell migration	GO Biological Process Annotations 2023	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
specific developmental disorder	GWASdb SNP-Disease Associations	1.0	0.212189
GSE100316_5_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145018
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54375
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9491
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07365
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	-1.0	-3.09735
MEX3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67507
outer SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.860036
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
depression	GWASdb SNP-Phenotype Associations	1.0	0.37373
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.586
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.44679
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913256
SP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.125429
Brain Lower Grade Glioma_LGG_TCGA-HT-7473-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57699
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828038
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-1126-SM-3NMBY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834358
Perturb_17289_OE_lncRNA5251_SRP239062	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.78252
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885312
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.223025
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70747
red nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17772
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-2826-SM-4DXTF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34806
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22417
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199665
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.952493
DOV13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56663
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of cell migration	GO Biological Process Annotations 2025	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15672_KD_Hnrnpc_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.90103
OVSAHO	CCLE Cell Line Gene Expression Profiles	1.0	1.56325
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55954
GABPA	ENCODE Transcription Factor Targets	1.0	null
LS180	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5714
lateral septal nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2008
chr3_41825294_G_A_b38	GTEx eQTL 2025	1.0	7.84601
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28569
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	2.02757
abnormality of the gallbladder	GWASdb SNP-Phenotype Associations	1.0	0.314374
regulation of p38MAPK cascade	GO Biological Process Annotations 2025	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q0-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spinal column	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.32497
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Protein kinase-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27610371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50736
BRD-K40276277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66724
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862873
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
NCI-H2291	COSMIC Cell Line Gene Mutation Profiles	1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29392
BHLHE40_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
periventricular stratum of JcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58107
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232347
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07771
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.921906
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128789
MCF7_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129475
NR2F2_01_89	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60727
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
all	GWASdb SNP-Phenotype Associations	1.0	0.097868
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.710832
Perturb_11505_KO_Brg1_SRP271459	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.44497
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50496
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.860198
NCIH838	CCLE Cell Line Gene Expression Profiles	1.0	2.12211
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052289
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.67858
GTEX-WEY5-0826-SM-4LMIH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02215
BRD-K10385824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51096
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14152
regulation of intracellular signal transduction	GO Biological Process Annotations 2023	1.0	null
Perturb_14217_KO_Mecp2_SRP061339	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.79216
Myeloid neoplasm	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
abnormal respiratory system morphology	MPO Gene-Phenotype Associations	1.0	null
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38599
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62437
E-7449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0677
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.86477
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142254
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BCL11A	ENCODE Transcription Factor Targets	1.0	null
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48398
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28992
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17053
D-502MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3579516__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Ehlers-Danlos syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MED15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00477
GTEX-PVOW-1026-SM-2XCF9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831609
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.831548
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70024
retromammillary area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.28056
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.842609
GTEX-WI4N-0726-SM-3TW93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21704
abnormal forebrain morphology	MPO Gene-Phenotype Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6828-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of phosphorylation	GO Biological Process Annotations 2015	1.0	null
Hydrocephalus	DisGeNET Gene-Disease Associations	1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34231
TBL1XR1_02_178	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62116
Multiple myeloma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.09379
Perturb_12008_KO_B2_Mm2_SRP374407	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.32694
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tunica media vasorum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.823
BRD-K39411863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60581
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16769
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.827648
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.16211
Ishikawa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.779
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.381199
cisplatin_homo sapiens_gpl570_gse23553	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44919
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-2.06019
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bone marrow disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4669_OE_Wdr5/Trp53|Wdr5_SRP324834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-T6MO-1726-SM-33HB8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06997
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.52509
organelle organization	GO Biological Process Annotations 2015	1.0	null
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.75175
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58763
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_3120_KO_Selenbp1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.08013
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01395
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13089873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14582
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF4-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_3007_KD_Satb1_SRP068358	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.59031
chr3_41841413_G_C_b38	GTEx eQTL 2025	1.0	2.28589
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D4-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161315
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K27147269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30028
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63833
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB33_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179248
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85568
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
A549_Iniparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123349
regulation of protein kinase C signaling	GO Biological Process Annotations 2023	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JA-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.966561
salivary gland	HPA Tissue Protein Expression Profiles	1.0	2.5471
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CI-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MONOMAC1	DepMap CRISPR Gene Dependency	1.0	2.26136
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
Diastolic Blood Pressure Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE-270	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.11641
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A148-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03772
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.945025
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.901488
NCIH1944	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40598
singlenucleotide	GeneRIF Biological Term Annotations	1.0	null
polymorphism	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184635
MCF7_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016483
KLF5-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840017
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
bad5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.985
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4098-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82386
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32719
regulation of phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_ZM 447439_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171814
lateral septal nucleus, intermedio-ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23576
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175039
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.45299
Perturb_13254_KD_Ncaph2_SRP073037	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.07809
FUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0705
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26472
Refractive error	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.65229
KE97	CCLE Cell Line Gene Mutation Profiles	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
NCCSTCK140	CCLE Cell Line Gene Mutation Profiles	1.0	null
Perturb_14937_KD_Pnky_SRP053095	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.13391
CL34	CCLE Cell Line Gene Mutation Profiles	1.0	null
accumbens nucleus, shell domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35413
CREBBP	ENCODE Transcription Factor Targets	1.0	null
BRD-K59185421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70259
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A197-06A-32R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126128
HT115	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-S7SF-0826-SM-4AD4W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2517
COLO684	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32386
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62791
triangular septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1935
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08235
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_5217_KO_Rnf2/Bap1_SRP162521	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.61
Striatum ventral region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45993
Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LCLC103H	CCLE Cell Line Gene Mutation Profiles	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.694
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93431
Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12569_KD_Sufu_SRP194252	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04504
ACC3	BioGPS Cell Line Gene Expression Profiles	1.0	1.02011
GSE100217_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Phosphopantothenoylcysteine decarboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.026
PMC10714175-mmc2.xlsx-KD_Gene_list-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52294
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.057353
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cortical microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.99
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28531
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8702_KD_MXD4_SRP374659	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.02797
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3049
Perturb_50_KO_Kat6a_SRP215863	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.6444
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34699
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lateral septal nucleus, rostral (rostroventral) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38674
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.0764
Perturb_9608_KO_Sirt7_SRP223932	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.52108
reuniens nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47162
MJ	CCLE Cell Line Gene CNV Profiles	1.0	1.55115
Diastolic blood pressure (long-term average)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.12218
MCF7_Quisinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104596
RPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30389
K562_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144159
Monoclonal gammopathy of uncertain significance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.658
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_targets-genes_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
Leukocyte disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.977
Perturb_3070_KO_Asb15_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.64255
Decitabine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0150064
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27771
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.06382
regulation of response to stress	GO Biological Process Annotations 2015	1.0	null
AMG-900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01151
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37101
NCIH510	CCLE Cell Line Gene Expression Profiles	1.0	1.35153
MCF7_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188144
abnormality of cardiac morphology	GWASdb SNP-Phenotype Associations	1.0	0.795267
A549_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017141
fat_a.V1	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14615
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.00935
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Field CA3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10015
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AD-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6956_KO_Tefm_SRP114827	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.1664
GTEX-XQ8I-0226-SM-4BOPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33672
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9236_KO_Kmt2d_SRP152944	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.19841
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.845523
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
monoclonal	GeneRIF Biological Term Annotations	1.0	null
GTEX-OHPL-2526-SM-3MJGT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06728
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
kinase	GeneRIF Biological Term Annotations	1.0	null
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8312
superficial layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20423
Perturb_8016_KD_MIDN_SRP361845	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.55589
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DDX31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39809
Perturb_5001_KO_Ctnnb1_SRP240867	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
layer 3 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59543
nucleus of the stria terminalis, medial division, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02757
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2006
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.402
BRD-K69903198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21655
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56808
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9686236-41598_2022_24611_MOESM1_ESM.xlsx-Suppl_Table_10-Supplemental_Table_10_Significant_genes_in_MR_analyses_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GBX2-23144817-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K76922696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07043
GSE201309_5_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_15674_KD_Hnrnpu_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.99323
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284023
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55059
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14011
BRD-K08805764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01326
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76061
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
CBX3	ENCODE Transcription Factor Targets	1.0	null
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162011
r9 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09881
Hippocampal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07896
eosinophils	GAD Gene-Disease Associations	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.710832
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8891017-41586_2022_4394_MOESM4_ESM.xlsx-ST6_-_MAF_enrichment-Unnamed_4_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
SMYD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24991
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14011
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NIHOVCAR3	CCLE Cell Line Gene Expression Profiles	1.0	1.82813
BRD-K10134498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03318
muscular disease	GWASdb SNP-Disease Associations	1.0	0.847971
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
family	GeneRIF Biological Term Annotations	1.0	null
MCF7_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125981
PMC8481886-Table_1.xlsx-A_subsets-bone_marrow_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_12785_KO_C5ar1_SRP097094	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.7304
ion binding	GO Molecular Function Annotations 2015	1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.5555
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126345_0_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_5252_KO_Klf2/Snd1_SRP311785	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
p1B part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14574
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33933
BRD-K12175788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03575
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9971
A549_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018708
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13351
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JV-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Topotecan (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0172233
NTS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15796
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_MLN8054_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127133
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
SOX11-22085726-ESNS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Spot adherens junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.82
BRD-K21450593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48383
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Fetal_Intestine_Large	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.49501
mantle zone of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.57364
NCIH716	CCLE Cell Line Gene Mutation Profiles	1.0	null
chr3_41903652_A_G_b38	GTEx eQTL 2025	1.0	5.08075
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136865
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
immune system phenotype	MPO Gene-Phenotype Associations	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14921_Mut_Atxn3_SRP155020	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.87892
Myosin filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.751
A549_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017528
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.980221
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.15865
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11088
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.76584
CBX3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
zuclopenthixol-2936	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_5_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14267_OE_Mir144_SRP305305	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Perturb_15680_KD_Srsf9_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.3083
dorsolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13792
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.32739
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1106
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.24756
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.608
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71948
BRD-K39223744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50891
Acute Myeloid Leukemia_LAML_TCGA-AB-2911-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
cell projection organization	GO Biological Process Annotations 2015	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26803
novobiocin-na	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15583
NUP160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08025
PDLIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24155
Saquinavir_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.021918
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2378_KD_Cdk8_SRP292215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.29744
medial subhabenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.3768
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
cerebral aqueductal stenosis	MGI Mouse Phenotype Associations 2023	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
Perturb_14568_KO_Got2_SRP348541	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.69701
A549_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127004
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0626-SM-32PM9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06815
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15713
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0522
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MF-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76385
dilated brain ventricles	MPO Gene-Phenotype Associations	1.0	null
premature death	MPO Gene-Phenotype Associations	1.0	null
A549_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160072
GSE146865,GSE146866_1_v_0_saracatinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KDM2B-26808549-CHIP-SEQ-SUP-B15-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21856
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13415
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12069
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XGQ4-2226-SM-4AT4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951268
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884136
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.182
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09981
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of myeloid leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.220663
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2172	CCLE Cell Line Gene CNV Profiles	1.0	2.17826
TTF2-22483619-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16373
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149179
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-KD-A5QU-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERBB3_drugactivation_70_GSE21463	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.19938
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14914
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43079
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Aortic aneurysm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
arteriosclerosis	GWASdb SNP-Phenotype Associations	1.0	0.408117
H3K4me1_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0926-SM-32PL2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16786
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
RXRA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0726-SM-3TW8S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06494
H3K4me1_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.591
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.17157
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.4279
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69214
HC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19036695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68792
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00359
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.992435
CTCF	ENCODE Transcription Factor Targets	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-RTLS-2426-SM-46MUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02517
K562_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141005
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.834776
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4848
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.959523
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.11062
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.84355
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3692
EP300	ENCODE Transcription Factor Targets	1.0	null
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.86029
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43377
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.754343
ASH2L	ChEA Transcription Factor Targets	1.0	null
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CYB5R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38376
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.95294
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-encode-consensu_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r4 part of medial paralemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16489
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08663
BRD-K30013451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32378
BRD-K49424866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43625
496100597_HIP_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.46095
SLC16A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17676
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-6D-AA2E-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.85085
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.919904
inferolateral temporal cortex (area TEv, area 20)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.882966
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79539
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92246
A549_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119568
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07156
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5829
intermediate stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04367
Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180951_2_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Triglyceride levels in HIV infection	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180951_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KP1N	DepMap CRISPR Gene Dependency	1.0	3.0546
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
estradiol_homo sapiens_gpl570_gse16683	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41514
Lung squamous cell carcinoma_LUSC_TCGA-60-2697-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML2-CLOSEST_GENE_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
vascular disease	GWASdb SNP-Disease Associations	1.0	0.330928
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.69403
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.21894
Perturb_1840_KO_Ifnar_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.92067
G292CLONEA141B1	DepMap CRISPR Gene Dependency	1.0	2.84411
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117198
solasodine-3924	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal brain ependyma morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_5868_KD_Cpsf6_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
KMS-11 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.637
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00778
GTEX-W5WG-1026-SM-4LMIF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08864
absent brain ependyma motile cilia	MGI Mouse Phenotype Associations 2023	1.0	null
MCF7_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017725
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174018
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987643
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12417
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00088
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19C-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sonidegib_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.017321
IRF4	ENCODE Transcription Factor Targets	1.0	null
Cytoproct	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.005
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100353_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45441
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01279
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39732
TP53	ChEA Transcription Factor Targets	1.0	null
TAL1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90526552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08833
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263916
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190669
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040345
BRD-K62917551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43974
Arrhythmogenic right ventricular dysplasia 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01335
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
CDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23493
transferase activity, transferring phosphorus-containing groups	GO Molecular Function Annotations 2015	1.0	null
intermediate stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1587
PTK7_knockdown_185_GSE50138	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.65636
Perturb_14924_KO_Atxn3_SRP155020	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.17255
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.757258
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.067953
H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879736
HNF4A	ChEA Transcription Factor Targets	1.0	null
A549_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173926
BRD-K48680503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03541
KP-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_7094_OE_miR128_SRP126105	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.29083
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4087
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal choroid plexus morphology	MGI Mouse Phenotype Associations 2023	1.0	null
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.88601
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.815
GSE154074_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18149487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45281
GTEX-P4QT-2026-SM-3NMCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35521
MEWO	CCLE Cell Line Gene Mutation Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R9-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
TE-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intermediate part of r6B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18826
GSE149075_8_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hematocrit	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.969897
brain	GAD Gene-Disease Associations	1.0	null
GTEX-S32W-0326-SM-2XCBI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883126
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LK-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMAD4-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
19139136-TableS3	GeneSigDB Published Gene Signatures	1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.34598
H3K4me1_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K23886631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2216
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839065
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.857595
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4562
K562_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166315
Panobinostat_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00994024
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834577
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Plasma membrane bounded cell projection cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.665
IZ in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.78019
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XC-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166162
decreased body size	MPO Gene-Phenotype Associations	1.0	null
BRD-K51448234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06389
rh30	HPA Cell Line Gene Expression Profiles	1.0	1.03445
IDRA-21	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62868
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90096
BRD-K82102697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3672
AZD1390_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00573496
Hemoglobin	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.01549
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29732
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.930179
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
GSE168797_2_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202284,GSE202289_1_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nervous system phenotype	MPO Gene-Phenotype Associations	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.771
GTEX-X3Y1-0226-SM-3P5Z5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21312
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z3-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187765
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43U-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.929498
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3073_KO_Ccl9_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.83437
GTEX-PSDG-1626-SM-48TCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6631
PMC2813300-pone.0008960.s011.xls-SOX2_squamous_signature-Gene_Symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	1.63529
Perturb_16649_KO_Tardbp_SRP201975	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.22694
BRD-K19603900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06144
GSE148066,GSE157787_8_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CREB1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
icSARS CoV_24Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.56999
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311138