association	dataset	threshold value	standardized value
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11404
HBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
No annotation - 1	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
NFE2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100634_HIP_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.46561
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.03744
Rifaximin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0127468
ERBB2_knockdown_234_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.29034
PABPN1	Pathway Commons Protein-Protein Interactions	1.0	null
H9 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.98135
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.67806
Sarcoma_SARC_TCGA-DX-A48U-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212989
K562_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270341
CDKN2AIP	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.992572
NCIH146	CCLE Cell Line Gene CNV Profiles	1.0	1.58545
VRK1	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45188
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.431829
EGR1	ChEA Transcription Factor Targets	1.0	null
ABL1	Pathway Commons Protein-Protein Interactions	1.0	null
PSMD11	Pathway Commons Protein-Protein Interactions	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
K562_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269744
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14304
ERBB2_knockdown_236_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.21205
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.717
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06155
PLK3_knockdown_121_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.5399
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25467
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08605
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.971138
BRD-K99252563_QL-XII-47_SKBR3_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
frontal pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.932546
CRCGN017_MCF10A.TP53.M_24H:K21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0951
LRWD1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostatic Neoplasms	dbGAP Gene-Trait Associations	1.0	0.527821
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318972
ABCF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.83404
ARAP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24205
DNM2	Pathway Commons Protein-Protein Interactions	1.0	null
P4HA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696863
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCD_KO_GSE24243_46_mouse_Skin (8-9 wk)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0256
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.535459
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.218186
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297956
A549_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205824
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.934992
nadh dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.219265
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-485-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
REN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650103
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPL22	Pathway Commons Protein-Protein Interactions	1.0	null
CSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1128
SNU503	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58699
BRD-K04918285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73271
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34595
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.957
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255182
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057025
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.56966
gene expression	GO Biological Process Annotations 2023	1.0	null
ability	GeneRIF Biological Term Annotations	1.0	null
UBN1	Pathway Commons Protein-Protein Interactions	1.0	null
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04363234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08611
GSE199255,GSE199356_3_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.502
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888468
Nevirapine_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0226551
TANK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005224
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
Trypanosomoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.061
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.827188
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.5568
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86974
Nuclear pore outer ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.775
K562_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018194
17638893-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81R-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36522
KRT18	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826817
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CPSF1	Pathway Commons Protein-Protein Interactions	1.0	null
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43151
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161043
ALCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31688
pm95	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.255
GSE114232_10_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Carnitine palmitoyltransferase I deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
BRD-K62800316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47176
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18383
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K89701103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06957
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
K562_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013044
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2066	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61933
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
RBM4	Pathway Commons Protein-Protein Interactions	1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.888269
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.582
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33304
Perturb_3019_KO_G6pd_SRP074231	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.82116
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5192-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMED10	Pathway Commons Protein-Protein Interactions	1.0	null
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCDC160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09538
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6497
UACA	Pathway Commons Protein-Protein Interactions	1.0	null
brain endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297806
forming	GeneRIF Biological Term Annotations	1.0	null
BRD-K87259147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09228
MAX_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ritonavir_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00968716
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.31175
BRD-K50836978_Purvalanol A_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125676
MYH10	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128233
BRD-K55679243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01375
ERCC6L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42333498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10006
RPS16	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-199b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827052
PMC8047442-EMBJ-40-e105492-s003.xlsx-MR_plot_analysis-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220303
EIF2D	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K82105033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79894
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.884458
K562_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166878
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ARFIP1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.7479
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SUPT20H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602864
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.9842
MRPL40	Pathway Commons Protein-Protein Interactions	1.0	null
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326335
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6X0-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233129
BRD-K92358687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17673
Lung squamous cell carcinoma_LUSC_TCGA-22-5481-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8352-01A-31R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81291
GSE215314_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
EM2	CCLE Cell Line Gene Expression Profiles	1.0	1.36018
TRUB1	Pathway Commons Protein-Protein Interactions	1.0	null
Messenger ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.279
Small nuclear ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.602
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055244
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PLZ4-1226-SM-2I5FE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47737
NCDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22702
HIST1H1D	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19562
PRCC	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0311479
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.67354
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150212
MCF7_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200841
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870047
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172477
NTRK3_drugactivation_67_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.6631
GTEX-S33H-2426-SM-2XCB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11571
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146978
MCF7_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182247
BRD-K60782883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54562
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058259
efo21	HPA Cell Line Gene Expression Profiles	-1.0	-1.62142
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K54067431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24885
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4492	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Speech disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
A549_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146197
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884985
NAT10	Pathway Commons Protein-Protein Interactions	1.0	null
Pollen mother cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
DDX17	Pathway Commons Protein-Protein Interactions	1.0	null
RH30_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.08616
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20936
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0447
hsa-miR-4727-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
A388	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.69733
K562_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262982
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCH	GDSC Cell Line Gene Expression Profiles	1.0	1.7636
BRD-K73296174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42911
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17040651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42358
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07945
BRD-K21479004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18623
HTRA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01873
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
U-2-OS	GDSC Cell Line Gene Expression Profiles	1.0	1.56839
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTPRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07182
ZBTB4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
monocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.174768
AGPAT1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990424
Nimesulide_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164594
XRN2	Pathway Commons Protein-Protein Interactions	1.0	null
PAXBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07116
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.103152
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.954852
BmN4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
bone marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111153
CRCGN015_MCF10A.TP53.M_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07265
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G7-01B-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1183	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF638	Pathway Commons Protein-Protein Interactions	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54F-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173636
SERPINE1	Pathway Commons Protein-Protein Interactions	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3NI-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MIR140_OE_GDS3461_575_mouse_C3H10T1/2 fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3636
K562_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216512
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS766T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58225
K562_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253057
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0859
Telomere cap complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.934
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50171
BCL11A	ENCODE Transcription Factor Targets	1.0	null
K562_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212568
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085961
INTS12	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KIF11	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109066
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.80961
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
SPTBN1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4793_KD_Tex10_SRP056038	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
K562_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147764
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.20618
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92460921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45858
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.08645
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.859749
Kinetoplastid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.987
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95191
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.827375
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.969987
K562_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146812
Carcinoma, Hepatocellular_Hepatic Tissue_GSE4612	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.97234
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL13	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.4598
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBFOX2	Pathway Commons Protein-Protein Interactions	1.0	null
Ski complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.356
Procyclic form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.943
BRD-A36630025_-666_HA1E_24.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.62687
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27362
EXOC3	Pathway Commons Protein-Protein Interactions	1.0	null
SMARCD1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016181
A549_SRT2104_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012601
LIMS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GSE199606_3_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20633
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132017
EIF3E	Pathway Commons Protein-Protein Interactions	1.0	null
AN3-CA	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.75934
SNRNP40	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016495
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990483
A549_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151445
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBA1C	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27136
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.702
HCT116	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.20492
INTS1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Danusertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150003
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24488
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	1.0	0.914313
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06681
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061129
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18952
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.35213
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17799
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237572
BRD-K07390518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14331
SRSF7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189779
UPF3B	Pathway Commons Protein-Protein Interactions	1.0	null
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0474
NCIH322	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68133
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13501
CPSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14996
Diphenhydramine_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0348721
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1676
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
RBM17	Pathway Commons Protein-Protein Interactions	1.0	null
Cytosolic ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.969
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45582
BATF	ENCODE Transcription Factor Targets	1.0	null
TUBB1	Pathway Commons Protein-Protein Interactions	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519107
Oxaprozin_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0132217
TUBA4A	Pathway Commons Protein-Protein Interactions	1.0	null
NUF2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24743998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00451
KCTD19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10601
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.97861
POLE	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K65959331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0552
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14542
PMC11327330-41467_2024_51380_MOESM4_ESM.xlsx-supfig05g-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.174632
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194864
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.898038
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60705
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bone disease	GWASdb SNP-Disease Associations	1.0	0.113761
CARD10	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PKCTHETA-26484144-CHIP-SEQ-BREAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13472433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33892
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Rucaparib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011401
NR2F2	ENCODE Transcription Factor Targets	1.0	null
Perturb_9913_KD_HNRNPK_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.36169
SRF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CYP51A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00410446
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100429_TCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10974
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54881917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40809
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056344
PrPC_KO_GDS4352_358_mouse_Developing hippocampus from FVB newborns (4.5-day-old)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K22481359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20757
RBBP5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18629365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11691
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5417597-pone.0176679.s006.xlsx-Tumor_MLL_vs_AT1-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPS19BP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7854845__F2	PFOCR Pathway Figure Associations 2024	1.0	null
TFCP2	Pathway Commons Protein-Protein Interactions	1.0	null
scaffolding	GeneRIF Biological Term Annotations	1.0	null
KIF4A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JW-0926-SM-4DM5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08216
MCF7_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166326
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01789
EIF3I	Pathway Commons Protein-Protein Interactions	1.0	null
MSX1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K12784613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.115
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117337
heart	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.3002
SNX12	Pathway Commons Protein-Protein Interactions	1.0	null
COLO-783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-0226-SM-4JBHG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973238
K562_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027317
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
WDR18	Pathway Commons Protein-Protein Interactions	1.0	null
NCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41025232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02377
PLRG1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
outer CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01365
EIF3L	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136948
TTC30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75792
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83159
ETS1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
K562_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016243
CRCGN009_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38775
BRD-K36168475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25315
ZNF527	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40931
K562_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166148
RFC2	Pathway Commons Protein-Protein Interactions	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-1026-SM-2TF4Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04501
U6 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.551
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TXN	Pathway Commons Protein-Protein Interactions	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.64833
HUWE1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202284,GSE202289_1_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBA5	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148813
BRD-K45508763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73766
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE62843,GSE64370_0_v_1_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06718
hsa-miR-4299	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
BRD-K80348542_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40675
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43075
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.8224
BRD-K54233340_Dorsomorphin dihydrochloride_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K22797212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30429
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16902
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059237
H3K27ac_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SAFB	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166238
catabolic process	GO Biological Process Annotations 2015	1.0	null
COPS5	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_9956_KD_SFPQ_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.78702
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.1858
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.57597
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TFG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13808
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rna metabolic process	GO Biological Process Annotations 2015	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX39A	Pathway Commons Protein-Protein Interactions	1.0	null
PUM2	Pathway Commons Protein-Protein Interactions	1.0	null
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
C1orf35	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ORC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29707
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851085
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ABL1_knockdown_100_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.65899
CDC27	Pathway Commons Protein-Protein Interactions	1.0	null
CLK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00573173
ZBTB33_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MCF7_Resminostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183317
Kidney Chromophobe_KICH_TCGA-KN-8436-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093544
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.868823
PCNT	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-332-CREM_CREM	Rummagene Transcription Factor Associations 2026	1.0	null
MAGEE2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180165
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AKAP8	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A5KG-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Genital pore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56158
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214355
Lucanthone_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0131862
CAPZA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE143643,GSE143644_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
blood coagulation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.091743
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1428	CCLE Cell Line Gene CNV Profiles	1.0	1.77707
Spliceosomal snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.614
NFYB	ENCODE Transcription Factor Targets	1.0	null
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2117
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873153
Symplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.835
BRD7	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.496
PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC25A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03983
BRD-A23434937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82457
BRD-K17953061_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PLK1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K62418408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73539
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63562
HSP90B1	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922982
GTEX-X261-0226-SM-3NMD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82787
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Usher syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
K562_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153765
GATA3-24758297-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
preweaning lethality	MPO Gene-Phenotype Associations	1.0	null
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199092
RIF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K80807286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3501
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
ribonucleoprotein granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.341529
VASP	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186361
MAP7	Pathway Commons Protein-Protein Interactions	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962865
GSE128240_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.8659
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.151
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192728
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE112995,GSE132079_1_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A89038047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23423
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PKP3	Pathway Commons Protein-Protein Interactions	1.0	null
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
DOCK8	Pathway Commons Protein-Protein Interactions	1.0	null
dementia	GWASdb SNP-Disease Associations	1.0	0.326719
CPSF6	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5151-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB48	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K84990603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44431
rna export from nucleus	GO Biological Process Annotations 2015	1.0	null
SPTAN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03067624_EMETINE HYDROCHLORIDE_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YES1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486645
PHF8	ENCODE Transcription Factor Targets	1.0	null
Perturb_12855_OE_Eif2a_SRP306641	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.18268
ectopically	GeneRIF Biological Term Annotations	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.050202
496100515_HIP_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.38837
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.01061
SREK1	Pathway Commons Protein-Protein Interactions	1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Endoplasmic reticulum Sec complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.82
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925207
NR2C2	Pathway Commons Protein-Protein Interactions	1.0	null
XPO1	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
monocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.17951
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RXRA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
exon-exon junction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.414
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K48699175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4392
BRD-K26689527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53513
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO Biological Process Annotations 2025	1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
STMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41656
GW body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.824
GRIN2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578864
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14444
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26152
RING1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99624
FLYWCH1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31123
MAFF	ENCODE Transcription Factor Targets	1.0	null
Myelodysplastic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
E4F1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5115-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
after	GeneRIF Biological Term Annotations	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF15	Pathway Commons Protein-Protein Interactions	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.29745
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86461
BRD-A31946439_NCGC00241077-01_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DOCK2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NOLC1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158407
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112860_5_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K11987248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.74316
CBFA2T3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09481
BRD-K31342827_GF-109203X_HT29_24.0_h_12.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stau1	GeneRIF Biological Term Annotations	1.0	null
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03589
A549_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142532
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.12368
A549_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209154
A253	COSMIC Cell Line Gene Mutation Profiles	1.0	null
USF1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10021
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16426
PITX1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151986
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4353-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC827	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93274
mRNA transport	GO Biological Process Annotations 2023	1.0	null
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.247545
hsa-miR-1231	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
TRIP12	Pathway Commons Protein-Protein Interactions	1.0	null
(R)-Verapamil (hydrochloride)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214749
PLS3	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36857
primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.88867
nuclear-transcribed mRNA catabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K78106941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58421
GCN1L1	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.979841
RUVBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26674
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.431041
A549_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124046
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USP2_KO_GDS5079_25_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MCF7_Bosutinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01106
RER1	Pathway Commons Protein-Protein Interactions	1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11709
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.27692
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.81307
A549_SGI-1776 free base_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115138
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_23-ZFX_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91119
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SF3B3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
SNRNP70	Pathway Commons Protein-Protein Interactions	1.0	null
GSE185519_6_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46356
DCP1B	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.870114
GTF2B	ENCODE Transcription Factor Targets	1.0	null
BRD-K95018971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73352
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-7848-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A24643465_homoharringtonine_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98637033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61748
EXOSC6	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179413
EIF4A2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K75534737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.04069
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37545
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07869
NELFE	ENCODE Transcription Factor Targets	1.0	null
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.910194
Brain Lower Grade Glioma_LGG_TCGA-DU-7299-01A-21R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-93-8067-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organ development	GO Biological Process Annotations 2015	1.0	null
K562_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190408
ACTL6A	Pathway Commons Protein-Protein Interactions	1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313569
ETS1	ENCODE Transcription Factor Targets	1.0	null
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05673
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AP1B1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0448869
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18446
either	GeneRIF Biological Term Annotations	1.0	null
CRCGN014_HEPG2_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7699
Hepatoma ascites cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.673
MAPKAPK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00284273
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.124548
pi-body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.477
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SMC3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33642
GTEX-XUZC-0226-SM-4BOO7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887353
BRD-K25127909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44502
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.16586
claustrum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.874121
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.18201
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42556
GTEX-SUCS-0526-SM-4DM56	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859501
Extensor digitorum brevis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.706
BRD-K70935154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52381
RPS6KA4	Pathway Commons Protein-Protein Interactions	1.0	null
APOBEC3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07487
CXCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41863
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16136812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53099
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	122.867
LOXIMVI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44863
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65856
TIMM44	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.3703
authors	GeneRIF Biological Term Annotations	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
SA1-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.851444
BRD-K62318087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46529
PMC11049885__F2	PFOCR Pathway Figure Associations 2024	1.0	null
NCI-H2066	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.06095
BRD-K12513721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07376
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14299
GSE132759_4_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXB9	Pathway Commons Protein-Protein Interactions	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
MCF7_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213908
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAG2	Pathway Commons Protein-Protein Interactions	1.0	null
Transcription export complex 2	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.009
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20323
ITK_defectivemutant_125_GSE28200	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.48801
GTF2I	Pathway Commons Protein-Protein Interactions	1.0	null
EHMT1	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SJ-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40803
homatropine-methylbromide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42231
PAQR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69054
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.974
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-514b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.80346
CAMK1G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501959
SNU-1040	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
BRD-K64591035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54923
hsa-miR-4522	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BV173	CCLE Cell Line Gene Expression Profiles	1.0	1.63443
7753_SEC61G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.643052
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.95573
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHERP	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.577
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PCF11	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8799469-41591_2021_1576_MOESM8_ESM.xlsx-Fig2e_-_E2F4_808g-SCENIC-predicted_targetome_for_E2F4_808g_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
CPSF4	Pathway Commons Protein-Protein Interactions	1.0	null
Mono-Mac-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.518
transcripts	GeneRIF Biological Term Annotations	1.0	null
GTEX-N7MT-0726-SM-3TW8S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60229
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_2day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.89287
BRD-K75380271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57914
BRD-K56893290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08293
RNA polymerase II, core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.329
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98447
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138493
Lung adenocarcinoma_LUAD_TCGA-91-6836-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057725
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPM1D	Pathway Commons Protein-Protein Interactions	1.0	null
PBX3	ENCODE Transcription Factor Targets	1.0	null
GTEX-PVOW-1626-SM-48TC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11245
u138mg	HPA Cell Line Gene Expression Profiles	-1.0	-0.825945
MCF7_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134059
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09335
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862354
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84628
BRD-K83919473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50938
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_HT29_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.16394
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72864
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.78586
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18603
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
telomeric DNA binding	GO Molecular Function Annotations 2025	1.0	null
RAP2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8752
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.833891
cytoplasm	GeneRIF Biological Term Annotations	1.0	null
GTEX-U3ZH-1426-SM-4DXSR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942501
TLN2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54003455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66789
DD-30-SX80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212665
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.891032
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03308
Brain Lower Grade Glioma_LGG_TCGA-P5-A780-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
Teratocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.265
cytoplasmic stress granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.184241
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
ARHGEF2	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3H	Pathway Commons Protein-Protein Interactions	1.0	null
RAMOS-2G6-4C10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
LDLRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A03997826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06534
BRD-K03791970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10249
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HNT-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.19912
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91885806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01231
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ERBB2_knockdown_231_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.13852
EDC4	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4456	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.82658
COPA	Pathway Commons Protein-Protein Interactions	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34243
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234557
BRD-A02333338_C3393M50_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
18614019-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
TNNI2	Pathway Commons Protein-Protein Interactions	1.0	null
PFKP	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-0426-SM-2HMK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824221
BRD-K73841784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21835
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145306
UQCRQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98305
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01973494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02785
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164016
upf1	GeneRIF Biological Term Annotations	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K21680192_mitoxantrone_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal neuron morphology	GWASdb SNP-Phenotype Associations	1.0	0.689348
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974483
Muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.84
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46068
GNAS	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0237477
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6829-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.995489
MCF7_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123895
HCFC1	ENCODE Transcription Factor Targets	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PARVA	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF16	Pathway Commons Protein-Protein Interactions	1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.3664
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K21680192_mitoxantrone_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02569
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04056
FAM83D	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67592986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3503
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.04225
RFC4	Pathway Commons Protein-Protein Interactions	1.0	null
exon	GeneRIF Biological Term Annotations	1.0	null
RA-86-LI22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273552
inferior rostral gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05592
hsa-miR-107	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HMCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543825
ABCF2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
Bloodstream form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
dermal dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.546136
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38441
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
while	GeneRIF Biological Term Annotations	1.0	null
DCTN2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7934853-jciinsight-6-141851-s210.xlsx-Beta3-Unnamed_0_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A193-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16426
SRSF3	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167622
reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.285417
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69468381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27211
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49866832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26942
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12089
BRD-K47349225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21859
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891009
BRD-K87107091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99499
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.118
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.04251
BRD-K80332123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25394
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827079
hsa-miR-219-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
required	GeneRIF Biological Term Annotations	1.0	null
BRD-K85395981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57184
Myoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.468
AE-52-FP96_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.585246
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0469533
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41787
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATR-ATRIP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.634
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.60813
BRD-A57285050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1697
U4 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.615
PMC5895607-41388_2017_42_MOESM4_ESM.xls-geneNames-Extended_Data_3_Gene_list_of_SRC-1_targets_which_contain_STAT1_binding_motifs_from_LY2_cell_RNAseq_data_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
SMARCC2	Pathway Commons Protein-Protein Interactions	1.0	null
GTPBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204396
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.01383
BRD-K72435943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17944
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-199a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K09248459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82922
BRD-K11730256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13392
MAX	ENCODE Transcription Factor Targets	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11503
HRH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39783
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8931
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung Diseases	CTD Gene-Disease Associations	1.0	1.13862
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21898
Penis_Foreskin_Keratinocyte_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.942212
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044955
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZRANB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09529
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54356
BRD-K28397270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01312
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.934176
MAP1LC3B	Hub Proteins Protein-Protein Interactions	1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.507
Huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
JHOS-4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.37973
EHD4	Pathway Commons Protein-Protein Interactions	1.0	null
JEG-3	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.41058
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.2741
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.877539
MCF7_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165538
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
OACP4C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RS4-11	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.24517
Encephalitis	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-4254	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
SRF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40166
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151289
SRSF11	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.878483
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41322154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84594
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K59922784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39265
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916649
NCOR2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TF1	CCLE Cell Line Gene CNV Profiles	1.0	1.74877
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966089
Lung Injury	CTD Gene-Disease Associations	1.0	1.05721
H3K23ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0274
thiocolchicoside-1726	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180237
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34542
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_115_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31895
4943_MED20_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.565128
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273471
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YQ-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
demonstrated	GeneRIF Biological Term Annotations	1.0	null
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.83819
KPNA1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rifaximin_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0148352
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947222
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09075
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NOB1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR3E	Pathway Commons Protein-Protein Interactions	1.0	null
Rd	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.734
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21409
Brain Lower Grade Glioma_LGG_TCGA-CS-6667-01A-12R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
SUPT20H	ENCODE Transcription Factor Targets	1.0	null
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47007
Frt	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.755
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A196-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85803608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7383
GALT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02716
K562_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181184
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44139
COPG2	Pathway Commons Protein-Protein Interactions	1.0	null
RNA polymerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.541
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01698
EE-98-PF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234058
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LTBR_INHIBITION - 2 Days_GDS2005_729_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
rheumatoid arthritis	GWASdb SNP-Disease Associations	1.0	0.572885
NB-24-VE53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348093
junction	GeneRIF Biological Term Annotations	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
exon-exon junction complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331825
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0504
K562_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173389
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18869
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81758631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31203
PMC11327330-41467_2024_51380_MOESM4_ESM.xlsx-supfig05d-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
CHD1L	Pathway Commons Protein-Protein Interactions	1.0	null
ME-62-IQ37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213867
daudi	HPA Cell Line Gene Expression Profiles	1.0	1.46456
HDAC2	Pathway Commons Protein-Protein Interactions	1.0	null
NUP155	Pathway Commons Protein-Protein Interactions	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
SUDHL5	CCLE Cell Line Gene Expression Profiles	1.0	1.4803
BRD-K66649343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85513
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305706
AKT1_OE_GDS2308_508_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3542
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50053
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76454
MCF7_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116776
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.615
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
KO52	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CBC581 (KDM5C)	NURSA Protein Complexes	1.0	null
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.126
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.63698
YBX3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58596567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69595
GSE205163,GSE205164_5_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11184788-40164_2024_526_MOESM4_ESM.xls-MSC-EV_proteins-Unnamed_4_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
FREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28633
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46978
MCF7_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160561
Inflammatory myofibroblastic tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.489
NCIH1793_LUNG	CCLE Cell Line Proteomics	1.0	4.93231
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070747
OTUD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75106
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43904
BRD-K90052868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03816
BRD-K53319404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07537
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LAS1L	Pathway Commons Protein-Protein Interactions	1.0	null
less	GeneRIF Biological Term Annotations	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921429
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100886,GSE100893_1_v_3_parp14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5393-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23292451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20071
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388199
A549_Decitabine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159857
G84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16703
Myocardial Infarction	CTD Gene-Disease Associations	1.0	1.03604
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EHD1	Pathway Commons Protein-Protein Interactions	1.0	null
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.947252
RPS19	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19800225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.62712
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93127164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20039
k562	HPA Cell Line Gene Expression Profiles	1.0	0.894544
BRD-K88378636_withaferin-a_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
TRMT1L	Pathway Commons Protein-Protein Interactions	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05873
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2621
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TANC2	Pathway Commons Protein-Protein Interactions	1.0	null
appear	GeneRIF Biological Term Annotations	1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.886502
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965959
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31390971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28995
NR2F6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE232472_1_v_2_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
SPI1	ChEA Transcription Factor Targets	1.0	null
USP2_KO_GSE43517_20_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234144
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.935783
BRD-K71415389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26967
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918427
CRCGN013_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11417
arthritis	GWASdb SNP-Phenotype Associations	1.0	0.19121
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KBM-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
CRCGN015_HEPG2_48H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22235
BRD-K05118861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15976
P69 prostate cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77857
DCTN1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fat_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.22684
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2494
NFATC1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX41	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1099
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
brain endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.327164
SUZ12	ENCODE Transcription Factor Targets	1.0	null
PARP4	Pathway Commons Protein-Protein Interactions	1.0	null
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.914467
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04874
Nuclear envelope lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.025
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Filgotinib_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.029793
VDR	ChEA Transcription Factor Targets	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.214017
Neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
K562_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223157
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.902759
RELA_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CPSF7	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
BRD-A42030853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39965
FANCI	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53611
BCL11A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Sm-like protein family complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.664
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01329192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16347
DMS454	CCLE Cell Line Gene CNV Profiles	-1.0	-2.5975
PR-DUB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
hsa-miR-4447	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
amygdaloid complex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.966478
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-11A-01R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08376
BRD-K01960204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81227
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50045741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60544
BRD-K94777797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77724
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
Tofacitinib_NCI-H596	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0352209
localization	GO Biological Process Annotations 2015	1.0	null
BRD-A06327019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23565
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
BRD-K92795658	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0312
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
codon	GeneRIF Biological Term Annotations	1.0	null
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917686
Perturb_2814_KD_TRIM25_SRP267938	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.0322
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
not applicable_Hypothermia_GSE54229_131_mouse_Embryonic fibroblas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09139
ZGPAT	Pathway Commons Protein-Protein Interactions	1.0	null
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.09188
BRD-K18822985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47863
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.71647
Lung adenocarcinoma_LUAD_TCGA-95-7567-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284172
CDX2-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K83875224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41764
olanzapine_rattus norvegicus_gpl1355_gds2608	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EKC/KEOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
prenatal lethality	MPO Gene-Phenotype Associations	1.0	null
BRD-K05584347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25661
Fetal Death	CTD Gene-Disease Associations	1.0	1.17629
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFYA-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161929
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92982
NCIH1568	CCLE Cell Line Gene CNV Profiles	-1.0	-1.94507
K562_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190919
BRD-K41355839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03511
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parolfactory gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17162
HS3ST3A1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8356
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leaf sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
10160_ZNF121_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.785149
MCF7_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140303
domains	GeneRIF Biological Term Annotations	1.0	null
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03934
Duchenne muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
GTEX-OXRN-1726-SM-3NM9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34995
K562_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183374
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08733
change	GeneRIF Biological Term Annotations	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:H14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23415
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL38	Pathway Commons Protein-Protein Interactions	1.0	null
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221358
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.09306
RNF17	Pathway Commons Protein-Protein Interactions	1.0	null
20460542-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
COPS3	Pathway Commons Protein-Protein Interactions	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.835056
MCF7_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151687
GFAP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188541
MCF7_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153762
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Larotrectinib_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0288506
Inflammation	CTD Gene-Disease Associations	1.0	1.7424
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAP2K7	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013232
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048211
osteoclast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.293151
BRD-K95810752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31062
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.36036
MET_knockout_253_GSE30651	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.49432
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23326916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54878
LNZTA3WT4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181184
GTEX-R55E-0826-SM-2TC5M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873363
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81804676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41779
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311114
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34978
Eukaryotic translation initiation factor 3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.196
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.92895
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.40713
Lsm1-7-Pat1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.301
Abiraterone acetate_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0110936
A549_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159811
Lung adenocarcinoma_LUAD_TCGA-78-7161-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
CLP1	Pathway Commons Protein-Protein Interactions	1.0	null
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
musculoskeletal system disease	GWASdb SNP-Disease Associations	1.0	0.063106
RBM8A	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHC1	Pathway Commons Protein-Protein Interactions	1.0	null
UT7	CCLE Cell Line Gene Expression Profiles	1.0	1.70894
ANAPC10	Pathway Commons Protein-Protein Interactions	1.0	null
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21187
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930974
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17555561-Table1	GeneSigDB Published Gene Signatures	1.0	null
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-V1D1-1726-SM-4JBHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910072
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899056
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149591
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
INTS6	Pathway Commons Protein-Protein Interactions	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048208
EIF3B	Pathway Commons Protein-Protein Interactions	1.0	null
DE-34-DT75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237629
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K81814927_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.859746
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33965
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510083
inner CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08672
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57262525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43927
JUND	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43567
CRCGN008_HEPG2_24H:G22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0798
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BL2745 (C1D)	NURSA Protein Complexes	1.0	null
SMN-Sm protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.832
SUPV3L1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_12843_KO_Tet2_SRP338315	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.9052
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.351
LIPE_KO_GDS1318_501_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
thrombocytopenia-absent radius syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.419
20101236-SuppTable7a	GeneSigDB Published Gene Signatures	1.0	null
RPS25	Pathway Commons Protein-Protein Interactions	1.0	null
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211084
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP7	Pathway Commons Protein-Protein Interactions	1.0	null
K562_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153107
BRD-K67750179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57911
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89783
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RELA_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0689
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03271
BRD-K65112040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22387
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO679	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41025
INS-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03173
RNF2	Pathway Commons Protein-Protein Interactions	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71228
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PLB985	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49843
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADCY9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51073
K562_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0301506
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.667
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TLN1	Pathway Commons Protein-Protein Interactions	1.0	null
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.4046
BRD-K26636241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11088
LU-99A	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
nuclear cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.24236
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.69442
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1267
temporal pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26201
hippocampus (hippocampal formation)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.834899
DHX15	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EH-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.943794
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BL1571 (ITCH)	NURSA Protein Complexes	1.0	null
G3BP2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13255
MORF4L2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K93774122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13193
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.50892
LRRC40	Pathway Commons Protein-Protein Interactions	1.0	null
ARF4	Pathway Commons Protein-Protein Interactions	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LRRC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4QS-1126-SM-3NMD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943117
SF126	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51757
K562_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158153
BCKDHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1064
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3679-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
BRD-K35288606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96983
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.38616
Seta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.909
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.82766
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87108
BE-31-XV38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30755
EIF2B4	Pathway Commons Protein-Protein Interactions	1.0	null
clomipramine-1566	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5526-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BA-88-HT15_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405474
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.653287
ZNF143	ENCODE Transcription Factor Targets	1.0	null
BB-62-MS83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225152
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chromatin silencing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.860311
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-A25687296_EMETINE_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94793
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.866575
CNOT1	Pathway Commons Protein-Protein Interactions	1.0	null
mRNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.644
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNPS1	Hub Proteins Protein-Protein Interactions	1.0	null
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRDM16-22522345-PALATE-MESENCHYMAL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NCIH2122_LUNG	CCLE Cell Line Proteomics	1.0	2.54812
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A38359809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48899
Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
DEPDC7	Pathway Commons Protein-Protein Interactions	1.0	null
Translation repressor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.056
Lung squamous cell carcinoma_LUSC_TCGA-77-7142-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
thrombocytopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.290462
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMARCAD1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.92484
PELO	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K57468571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51439
GSE146687_2_v_0_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4498	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017164
UCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054447
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K82868643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19226
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962797
CWC15	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.63421
DNAJC9	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0441508
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849926
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03704
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
SCYL2	Pathway Commons Protein-Protein Interactions	1.0	null
recognize	GeneRIF Biological Term Annotations	1.0	null
GSE193258,GSE193259_5_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
stratum pyramidale of caudal CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0317
GPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39194
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49131
smallintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.15169
Glaucoma_Retina_GSE3554	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.96411
Ribonuclease H2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.739
CHD7	ENCODE Transcription Factor Targets	1.0	null
Perturb_506_OE_GPD1_SRP252809	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.524466
BRD-K93032100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06675
SPATA5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135669
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.386
GEMIN6	Pathway Commons Protein-Protein Interactions	1.0	null
TET2_KO_GDS4287_429_mouse_LSK - bone marrow progenitor population	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CHD8	Pathway Commons Protein-Protein Interactions	1.0	null
FG syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.486
AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230184
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51653
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145619
K562_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144558
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931662
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
Hydroxyfasudil_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244661
A549_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165457
NHLRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76053
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
9592_UNC45A_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.698133
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.592
nucleus	GO Cellular Component Annotations 2023	1.0	null
A549_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201096
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
seminiferous tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193783
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.949557
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A97N-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
SETX	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60430317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.454
nucleus	GO Cellular Component Annotations 2015	1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91419355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5462
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.6659
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.988012
BRD-K64137284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43697
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09615
CP21R7_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0098187
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7483-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol_homo sapiens_gpl6102_gse11567	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959281
Cytoplasmic ribonucleoprotein granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.391
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K96250732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06532
K562_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015035
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29616
SMCHD1	Pathway Commons Protein-Protein Interactions	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22861
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.873276
K562_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196997
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221195
FOXA2	ChEA Transcription Factor Targets	1.0	null
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNW1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-320e	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
Testicular cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.119
GSE210101,GSE210114_1_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.35451
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH1693	CCLE Cell Line Gene CNV Profiles	-1.0	-2.15775
Brain Lower Grade Glioma_LGG_TCGA-TM-A84J-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHAF1A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240738
COMTD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23074
LEF1-29337183-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42966513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07395
GB-01-UN23_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223012
MEF2A	ENCODE Transcription Factor Targets	1.0	null
GTEX-P4PP-1826-SM-2S1NT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09564
GSE232564,GSE232566_3_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8876_KD_ABCB6_SRP309466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TAF5L	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
MCF7_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232377
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
LS-174T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15928
C7orf13	Pathway Commons Protein-Protein Interactions	1.0	null
DRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00415314
A172_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	4.52401
SUMO1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16472
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
BRD-A30437061_Camptothecin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
atpase	GeneRIF Biological Term Annotations	1.0	null
vorinostat_homo sapiens_gpl10558_gse35242	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DDX19A	Pathway Commons Protein-Protein Interactions	1.0	null
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36346
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUGT1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01093
K562_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179753
PDE6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11143
PPP1R12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02518
U5 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.993
K562_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0282472
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
nuclear part	GO Cellular Component Annotations 2015	1.0	null
BRD-A13122391_16-HYDROXYTRIPTOLIDE_MCF7_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
b220.bcell	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.12224
Perturb_10857_KO_Shp_SRP220815	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.53298
BRD-A21584932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01436
BRD-K88925664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21531
heart	GTEx Tissue Gene Expression Profiles	-1.0	-1.0344
Testicular cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.253
BRD-A39660642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15824
cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35588
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.49499
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315861
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956316
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.981466
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.20229
Recessive dystrophic epidermolysis bullosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
Nonsense-Mediated Decay (NMD)	Reactome Pathways 2014	1.0	null
GSE182680,GSE182683_0_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ribosome	GeneRIF Biological Term Annotations	1.0	null
nonsensemediated	GeneRIF Biological Term Annotations	1.0	null
KMM1	CCLE Cell Line Gene CNV Profiles	1.0	1.43064
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133645
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00337317_NU-7441_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.69
RFC5	Pathway Commons Protein-Protein Interactions	1.0	null
PHGDH	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_I-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81372179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30187
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.997957
GTF3C3	Pathway Commons Protein-Protein Interactions	1.0	null
A549_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203149
BRD-K75703503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14449
K562_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019888
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04769
TPR	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56572622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24895
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4760-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
Signal recognition particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.161
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.605306
Down Syndrome_Fetus_GSE10758	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.27935
PAXIP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135030_8_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020069
A549_UNC1999_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135704
MCF7_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215451
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BAZ1A	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20423
Microgametophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NANOG-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
BZW2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36522
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1637
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNRPB2	Pathway Commons Protein-Protein Interactions	1.0	null
DPF2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216979
BRD-K98140933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01933
BRIX1	Pathway Commons Protein-Protein Interactions	1.0	null
PDCD6IP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-513c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE158834_7_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0286433
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4004
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194452
occipito-temporal gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06657
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40943
Lung adenocarcinoma_LUAD_TCGA-71-6725-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10065
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.602489
Osteoclastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87479423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11528
K562_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176467
MAD1L1	Pathway Commons Protein-Protein Interactions	1.0	null
CTSZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68006
LCN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38541
cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.123774
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.59631
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
embryonic lethality	MPO Gene-Phenotype Associations	1.0	null
mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN)	CORUM Protein Complexes	1.0	null
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
Ulcerative Colitis_Peripheral blood mononuclear cell_GSE3365	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.84651
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08561
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.97539
NANOG	ChEA Transcription Factor Targets	1.0	null
GTEX-WRHU-1026-SM-4E3ID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1137
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.266519
RELA_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14375790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38926
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51843
Belumosudil (mesylate)_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0288191
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30964167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1615
interacts	GeneRIF Biological Term Annotations	1.0	null
GSE211286_1_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943199
CELF2	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51075
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFYA	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77589
protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941331
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26458
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11272
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.880584
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14396
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DYNC1LI1	Pathway Commons Protein-Protein Interactions	1.0	null
TUBA3E	Pathway Commons Protein-Protein Interactions	1.0	null
GSE236511_1_v_0_ngfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046267
GSTP1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3074-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
MCF7_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106679
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.501
RPS18	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21657
RXRA	ENCODE Transcription Factor Targets	1.0	null
ASF1A	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134172
CRCGN009_HEPG2_24H:G21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00315
A3-KAW	GDSC Cell Line Gene Expression Profiles	1.0	1.42794
BCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42473
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSRP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516385
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.28583
VPS33B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13564884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21985
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16138
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.556356
BRD-K34026318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05603
A549_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0330711
Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.701899
BRD-K43872193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24342
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hep2c	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
BRD-K93941597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12886
AP1S2	ChEA Transcription Factor Targets	1.0	null
cingulate gyrus, frontal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17734
ARID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73508
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26672
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.6124
BRD-K30326216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3252
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adenocarcinoma of lung_Lung Tissue_GSE11969	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.74109
K562_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198063
SMARCA2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54898824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18772
DMAP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180067
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K86111620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12095
WAPAL	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.35239
BRD-K35001076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23289
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924622
ART4	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4726-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
RUNX3	ENCODE Transcription Factor Targets	1.0	null
their	GeneRIF Biological Term Annotations	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.90089
lung	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.875378
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183584
primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.891727
FA-02-RV60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239007
BRD-K45097650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82373
AHNAK	Pathway Commons Protein-Protein Interactions	1.0	null
SRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16775
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.872347
KASUMI6	CCLE Cell Line Gene Expression Profiles	1.0	2.3033
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299872
SRF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Benztropine (mesylate)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0193337
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01044
FYTTD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865472
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7407
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F3-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06549
BRD-K18888894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20906
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
miR-124_OE_GDS2657_770_human_HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.70113
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hel	HPA Cell Line Gene Expression Profiles	1.0	2.17654
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR1C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12628
Brimonidine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140285
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.4128
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EXOSC4	Pathway Commons Protein-Protein Interactions	1.0	null
Pentoxifylline_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.015236
PMC2976970__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
BRD-K00615600_AG14361_MCF7_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCIH661_LUNG	CCLE Cell Line Proteomics	1.0	4.33607
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
MSH2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5113-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43936610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18301
CTCF-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K35780971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60125
Lung squamous cell carcinoma_LUSC_TCGA-77-A5GH-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38358574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35227
SNRPA	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SMG6	Pathway Commons Protein-Protein Interactions	1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.666997
KMS27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52496
DNAJC13	Pathway Commons Protein-Protein Interactions	1.0	null
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.835249
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861006
PMC10061014-Table7.XLSX-C_vs_L-Table_S7a_Predicted_upstream_regulators_of_genes_showing_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99771
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.7853
Intrahepatic cholestasis of pregnancy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
NCI-H1355	COSMIC Cell Line Gene Mutation Profiles	1.0	null
APOD_OE_GDS3913_489_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.8822
BRD-A59985574_T542500_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN008_HEPG2_24H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2107
ERCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44698
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59312
CEP55	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K59064238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66709
SEPT9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_99_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.645
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13786
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0309896
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.04378
bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078165
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lamellar body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.1632
Lung adenocarcinoma_LUAD_TCGA-50-7109-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4256
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51757
ASH2L	ChEA Transcription Factor Targets	1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.424654
BRD-K01668149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54326
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1906
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HD-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nuclear part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERBB2_knockdown_232_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.86319
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91064
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.87351
CLASP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25222
MCF7_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139385
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12229841-Table2.xlsx-BL_NS_vs_BL_LPS-Negative_logFC_up_at_non-stimulated_Postive_logFC_up_after_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
PNN	Pathway Commons Protein-Protein Interactions	1.0	null
Schmid metaphyseal chondrodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.593
MCF7_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267203
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25207
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
DRG1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K38966099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86479
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
IA-65-QX27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203439
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MLH1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.456442
choroid plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250301
PMC10635891-mmc2.docx-1-ZNF318_ZNF318	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4437	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.509424
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HU-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.555973
CDC20	Pathway Commons Protein-Protein Interactions	1.0	null
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.137617
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.36614
GSE205163,GSE205164_2_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11927976_ER 27319 maleate_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRKAG1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.970913
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04775
CRCGN013_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03515
MCF-7 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.882226
SIN3A	Pathway Commons Protein-Protein Interactions	1.0	null
SEC24C	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135908
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70735803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47968
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62853
GATA1_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.00634
Nucleomorph	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.14747
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184791
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SMN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.834
Supraspliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.92
TK1	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKA3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196969
NUP93	Pathway Commons Protein-Protein Interactions	1.0	null
CSK	Pathway Commons Protein-Protein Interactions	1.0	null
Microcytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HZ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166548
TAL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
PRDM16	ChEA Transcription Factor Targets	1.0	null
SMARCC1	Pathway Commons Protein-Protein Interactions	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.615532
H2AK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF254	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00068
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
ATF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PPFIA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00630082
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607705
BRD-K47801291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4944
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307759
intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.332121
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49396
HMMR	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TYMS	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P44H-0726-SM-48TBT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13655
TMOD3	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR3D	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	3.01223
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
activities	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YW-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARHGEF1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.570496
POLD1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173164
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.4495
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188924
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25467
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05475
MCF7_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226517
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.03161
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05649
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07044
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3HQ-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HE-80-BQ08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439641
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225542
MCF7_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0241846
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
GOLGA4	Pathway Commons Protein-Protein Interactions	1.0	null
BPH-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.64781
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59457
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.882638
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SB-202190-6882	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.061764
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.381495
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58843
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.96359
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36641
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969892
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11376
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870772
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.40218
External female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.339
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.605
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.1147
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20095
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35805
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18172
Protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.717
A549_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238101
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6858
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
BRD-K70148902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12285
MCF7_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174542
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019769
NFATC1	ENCODE Transcription Factor Targets	1.0	null
decay	GeneRIF Biological Term Annotations	1.0	null
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04942
A549_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133777
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1635
Roxadustat_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00703167
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057252
Epidermolysis bullosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
Cytosolic small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.792
API5	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36194
Immunodeficiency 51	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
BRD-K82432417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73615
SND1	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.61683
BRD-K12862541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61111
GSE146074_9_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BRD-K83690550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13498
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Idiopathic pulmonary fibrosis disease specific cell type	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.184
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Ofloxacin_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123107
GTEX-P4QT-1826-SM-2S1NJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06243
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03623
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166714
BRD-K60337657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83515
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146176
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SNRNP35	Pathway Commons Protein-Protein Interactions	1.0	null
premature	GeneRIF Biological Term Annotations	1.0	null
K562_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02714
GTEX-WRHK-1726-SM-3MJFK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41953
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.72699
BRD-K40745976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48778
BRD-K06398048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.21685
HELLS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-0326-SM-3MJGV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879792
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07716
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864298
DYNC1LI2	Pathway Commons Protein-Protein Interactions	1.0	null
olanzapine_rattus norvegicus_gds2608	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A7UU-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7861-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06615
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657914
BRD-K90872016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99269
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
synapse-associated extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.993
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.079979
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209663
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H4K91ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K40814141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0161
6062_PAPOLA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58151
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66489
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amyotrophic lateral sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.689348
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0677
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21818
NFYB-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_Abexinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112799
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K88583132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59114
KTI12	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.066044
etofylline-1409	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC42EP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17139
upf3b	GeneRIF Biological Term Annotations	1.0	null
BRD-K77845452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32719
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
Perturb_9728_KD_CDYL_SRP234405	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.6622
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51272
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10198
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mel-CV cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.53
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855274
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36915
BRD-K66559139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20382
Scale	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69347147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01735
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.99035
Becker muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
TEAD4	ChEA Transcription Factor Targets	1.0	null
BRD-K35422614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06717
BRD-K32522654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25557
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Cytoplasmic stress granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.844
BRD-K50603336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03233
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VB-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235136
ERBB2_knockdown_233_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.85368
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS28	Pathway Commons Protein-Protein Interactions	1.0	null
Abiraterone acetate_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0202299
BRD-A16827030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66569
TNFAIP2	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMC3	Pathway Commons Protein-Protein Interactions	1.0	null
OXSR1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE220520_3_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.14175
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.835054
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DAUDI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239117
K562_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164219
K562_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209903
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.441312
BRD-K62504352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36061
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19584
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19561
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-1426-SM-2S1P5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867579
TAL1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07191
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
S1PR5	Pathway Commons Protein-Protein Interactions	1.0	null
17210682-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GSE112860_5_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47165178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82171
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23894
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PISD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06472
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254301
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4c-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133646
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36453
MPP-89	COSMIC Cell Line Gene Mutation Profiles	1.0	null
glioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.471539
CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08644
TUBGCP3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228524
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.67015
GSE158834_11_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07565511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67705
TOP3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4275
CDC42	Pathway Commons Protein-Protein Interactions	1.0	null
Hereditary diffuse gastric cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254835
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF408	Pathway Commons Protein-Protein Interactions	1.0	null
MSH6	Pathway Commons Protein-Protein Interactions	1.0	null
HNF4alpha_KO_GDS1915_173_mouse_Small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-3974	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
DGCR14	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S33H-1126-SM-2XCB6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9219
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016845
SEC31B	Pathway Commons Protein-Protein Interactions	1.0	null
ABCG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19921
all	GWASdb SNP-Phenotype Associations	1.0	0.03965
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
MTA2	Pathway Commons Protein-Protein Interactions	1.0	null
Perineuronal net	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.997
sertoli cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.614571
Neuronal ceroid lipofuscinosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825878
LENG9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50111
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939712
eukaryotic translation initiation factor 3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.234533
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
mortality/aging	MPO Gene-Phenotype Associations	1.0	null
BRD-K76251351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35574
BATF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99545815_HY-10459_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8807392-41375_2021_1393_MOESM2_ESM.xlsx-data_integration-YBX1_iCLIP-targets_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36743230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28352
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.773
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.951905
HEPG2_LIVER	CCLE Cell Line Proteomics	1.0	2.54812
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29917
NCI-H1048	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
related	GeneRIF Biological Term Annotations	1.0	null
UPF1	Pathway Commons Protein-Protein Interactions	1.0	null
5885_NUP107_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.537879
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15931
initial	GeneRIF Biological Term Annotations	1.0	null
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.50214
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HSF1_KD_GDS1733_757_human_HeLa cells - 4 Hour by siHSF1_2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K91876603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7305
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRRM2	Pathway Commons Protein-Protein Interactions	1.0	null
BCLAF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30214445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03653
RPL30	Pathway Commons Protein-Protein Interactions	1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.968403
A549_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140571
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92109
NOMO-1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
SYMPK	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.109
Prespliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.764
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GU-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Junctional epidermolysis bullosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
PTBP3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85263
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00509345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2208
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	155.525
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76051
CHD7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K89537738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.61251
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8706
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GRIN2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00823024
A549_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155554
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K41026056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44505
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14104
Fenofibrate_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0279143
BRD-K51666223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50984
GTEX-PX3G-1526-SM-48U11	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835101
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
LB2518-MEL	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49668
15543619-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
NDUFA7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CHD3	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
PAIP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO Biological Process Annotations 2023	1.0	null
XPO6	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138645
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
establishment of rna localization	GO Biological Process Annotations 2015	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21102
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60811
BRD-K62193937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25052
BRD-K84706257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43321
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90088
ETF1	Pathway Commons Protein-Protein Interactions	1.0	null
diethylstilbestrol_mus musculus_gpl6887_gse37969	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946179
osteogenic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.144757
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226314
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_ZM 447439_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136797
IRF4_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26863838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44403
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ILK	Pathway Commons Protein-Protein Interactions	1.0	null
osteosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.270214
TBL1-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ATR	Pathway Commons Protein-Protein Interactions	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
MRE11A	Pathway Commons Protein-Protein Interactions	1.0	null
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070228
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06616
DDX39B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04472
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41412
CEBPB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRMT1	Pathway Commons Protein-Protein Interactions	1.0	null
PSMC5	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-1273d	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
GTEX-RM2N-0126-SM-48FDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984309
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
organ regeneration	GO Biological Process Annotations 2015	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79607
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.877539
alzheimer's disease	GWASdb SNP-Disease Associations	1.0	0.511604
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8762
CCL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00504122
STAT3	ChEA Transcription Factor Targets	1.0	null
hsa-miR-1587	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MVP	Pathway Commons Protein-Protein Interactions	1.0	null
INTS3	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178843
Myelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
A549_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130325
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43258
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.673
BRD-K53752646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36596
BRD-K23361743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35687
HT-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.734
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
6119_PCF11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17749
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2447
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38555
Quinestrol_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0153353
RAGE_knockout_268_GDS3755	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.09583
NCIH2196	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71492
supporting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.199673
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HTATSF1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024087
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAP1A	Pathway Commons Protein-Protein Interactions	1.0	null
IGR37	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87431
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31267
Diverticular disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
DE-99-OT37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225442
SUPT20H_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic mrna processing body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.164089
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S194/5.XXO-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.494
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222357
NFYA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
SC-197 (MAX)	NURSA Protein Complexes	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2984
gene expression	GO Biological Process Annotations 2015	1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.60812
CUL1	Pathway Commons Protein-Protein Interactions	1.0	null
19286929-SuppTable2q	GeneSigDB Published Gene Signatures	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
aberrant	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EA-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.865474
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A59985574_T542500_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perlman syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
CCDC117	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54546
nuclear transport	GO Biological Process Annotations 2015	1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.612646
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.56
BRD-K68683482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17418
BRD-K49401787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38735
BRD-K24599650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57731
BRD-K54260552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13057
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE193249_0_v_1_gpx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.884426
element	GeneRIF Biological Term Annotations	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
PAX5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPNE3	Pathway Commons Protein-Protein Interactions	1.0	null
LMO7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826154
HA-E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5550_NDUFAF7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.592281
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.27203
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
C6 glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245427
A549_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0313171
BRD-K15563106_-666_A549_6.0_h_177.6_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YN-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22044
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.378507
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.428179
MCF7_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138583
BRD-K16717067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24727
hsa-miR-625	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
P30-OHK	GDSC Cell Line Gene Expression Profiles	1.0	1.61054
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZW-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-155-5p	MiRTarBase microRNA Targets	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22521
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.77236
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUP107	Pathway Commons Protein-Protein Interactions	1.0	null
NSF	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
RANBP2	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203936
Citalopram (hydrobromide)_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0273238
NOMO-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.949
hsa-miR-127-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HT1197	CCLE Cell Line Gene CNV Profiles	1.0	2.16754
hsa-miR-4472	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.369684
PMC12830621-41467_2025_67611_MOESM11_ESM.xlsx-Sheet1-Suppl_Data-9_Common_differentially_up-regulated_genes_in_high_vs_low_Mecom_MECOM_mouse_KME_AML_cells_and_human_AML_from_4_public_databases_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33132
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12737
primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17098
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF44	Pathway Commons Protein-Protein Interactions	1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBM10	Pathway Commons Protein-Protein Interactions	1.0	null
cervical adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.152942
ASAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.148
K562_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0349483
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MBNL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00393492
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22898
BRD-K89089981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52094
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K51196703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24133
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159696
PMC9048904__F6	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K56826759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22267
CREB1	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05774
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45428339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.81908
A549_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129413
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KANSL1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal joint morphology	GWASdb SNP-Phenotype Associations	1.0	0.160875
NXF1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.862476
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MF-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1682
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07502463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97478
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01111
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10875
Learning Disorders	CTD Gene-Disease Associations	1.0	1.47736
ANAPC2	Pathway Commons Protein-Protein Interactions	1.0	null
DIAPH1	Pathway Commons Protein-Protein Interactions	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZH-1726-SM-3DB79	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11651
RITS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.519
NIPAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28399
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935654
KAT2B	ENCODE Transcription Factor Targets	1.0	null
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Prostate cancer (gene x gene interaction)	GWAS Catalog SNP-Phenotype Associations	1.0	0.246511
JAK2_activemutant_178_GSE44961	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.75816
CTCF	ENCODE Transcription Factor Targets	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25546
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.042
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825435
Azoospermia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.88071
NFIC	Pathway Commons Protein-Protein Interactions	1.0	null
GPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30598
BRD-K72173400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44172
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06299
BRD-K31616862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35604
TUBA1A	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB33_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-149	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
substantia nigra, reticular part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.858213
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0648
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
upf2	GeneRIF Biological Term Annotations	1.0	null
USP10	Pathway Commons Protein-Protein Interactions	1.0	null
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.967124
DOK	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4222
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CSTF3	Pathway Commons Protein-Protein Interactions	1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
BRD-K17610834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37847
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30893
Prostate adenocarcinoma_PRAD_TCGA-EJ-7793-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.783057
KIF21A	Pathway Commons Protein-Protein Interactions	1.0	null
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3152
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K08939002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1141
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34361
BRD-K45318035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05235
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.82874
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PPM1H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97263
SCRIB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MK-8353_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0142194
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18497
skeletal muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061061
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.2096
BRD-K22069962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83966
VCP	Pathway Commons Protein-Protein Interactions	1.0	null
small intestine cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.419623
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
OMC-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.84837
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U4-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955888
A549_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210373
BRD-A21891180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14136
male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.285417
Verteporfin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0101694
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08224
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.57954
K562_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181069
BRD-K76706127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57049
RPL13A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18149487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05678
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.34418
oxidoreductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.093629
triggering	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4665-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5459
PDCD6	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205699
reproductive organ cancer	GWASdb SNP-Disease Associations	1.0	0.296563
BRD-K77820762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3087
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.462236
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX23	Pathway Commons Protein-Protein Interactions	1.0	null
ATF3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bromopride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4996
Ornidazole_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.031467
Cytosolic large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.564
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27016
GTEX-XV7Q-0226-SM-4BRVL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02937
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19043
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal survival	MPO Gene-Phenotype Associations	1.0	null
PMC4332150-msb0011-0775-sd13.xlsx-JUN-Prey_Gene_Symbol_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCOR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43779
BRD8	Pathway Commons Protein-Protein Interactions	1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5392
hsa-miR-3943	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
AIRE_KO_GDS2274_246_mouse_Medullary thymic epithelial cells (with high CD80 expression)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_7253_KD_CYFIP2_SRP267677	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.56039
BRD-K09699976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03259
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Embryonic brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.108
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
Erythromycin_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0151389
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8669_TAF7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526405
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.913348
BRD-K85627183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04784
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IA-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
USF1	JASPAR Predicted Transcription Factor Targets	1.0	null
17952126-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Shoot apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.663
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7784
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2E	Pathway Commons Protein-Protein Interactions	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.440211
BRD-K83218047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37541
encounter	GeneRIF Biological Term Annotations	1.0	null
BRD-K19776718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64217
A549_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209751
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
p1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Flutamide_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00999789
ACTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49061
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55517
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
FCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03469
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A36630025_-666_WSUDLCL2_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
THOC2	Pathway Commons Protein-Protein Interactions	1.0	null
IER3IP1	Pathway Commons Protein-Protein Interactions	1.0	null
TUBB3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Valdecoxib_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164822
BRD-K30105551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.70872
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21203
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_NK_cells-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL11A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.51878
TRIP13	Pathway Commons Protein-Protein Interactions	1.0	null
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233679_12_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05127
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3374-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CCL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509887
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
Mozavaptan_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0428679
ZAP70	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647444
Facioscapulohumeral muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
MED16	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39827
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969071
NFYA	JASPAR Predicted Transcription Factor Targets	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.909736
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57462
SD-69-IX30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212463
BRD-K56086519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64472
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43685
CD4+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.894733
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01563
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Osimertinib (mesylate)_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0229252
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.7339
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4676
impaired	GeneRIF Biological Term Annotations	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.038145
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.879327
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70203
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RBPMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54141
MCF7_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158548
TBP	ENCODE Transcription Factor Targets	1.0	null
INTS8	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN009_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23777
PRC1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014945
organelle part	GO Cellular Component Annotations 2015	1.0	null
EDS1 disease-resistance complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
Prostate adenocarcinoma_PRAD_TCGA-EJ-5508-01A-02R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.20101
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827052
H3K9me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
AF-12-IW93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.674057
respiratory chain complex i	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.449643
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
eltanolone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60298
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44242
HDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41753
CRCGN017_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2803
PRKCA_knockdown_118_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.60805
BRD-K01358985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03628
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52566202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76385
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0116777
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.992572
A549_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151856
LRRC47	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.589
PSMC4	Pathway Commons Protein-Protein Interactions	1.0	null
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.983372
MCF7_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149795
RBM7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24132293_piperlongumine (HPLC)_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BL7553 (DICER1)	NURSA Protein Complexes	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
temporal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.946801
GMPS	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5583-01A-02R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4T-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89174739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10224
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07986
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.21141
PSTPIP2	Pathway Commons Protein-Protein Interactions	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
nucleic acid binding	GO Molecular Function Annotations 2015	1.0	null
GADD45GIP1	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VK-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
NRF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5645
USF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SREBF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618753
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02491
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959453
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU-DHL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22452
adrenal_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.0555
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K95709431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96987
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27589
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.845105
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DNAJA2	Pathway Commons Protein-Protein Interactions	1.0	null
USP39	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
KIF27	Pathway Commons Protein-Protein Interactions	1.0	null
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GATAD2A	Pathway Commons Protein-Protein Interactions	1.0	null
RPS13	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K71015709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.87175
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Activating signal cointegrator 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.592
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ACTR2	Pathway Commons Protein-Protein Interactions	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDM1	ENCODE Transcription Factor Targets	1.0	null
AASS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584964
KASUMI2	CCLE Cell Line Gene Expression Profiles	1.0	1.50671
K562_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171289
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RBM45	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H520	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.56008
BRD-K88671309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81741
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
SMG8	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-DX-A1KY-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT1-20625510-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BACH1	Pathway Commons Protein-Protein Interactions	1.0	null
496100629_HIP_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17326
K562_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155604
HDAC1	ENCODE Transcription Factor Targets	1.0	null
Nuclear cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.164
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	148.426
disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.285417
FOXA1-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K59095205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26405
mRNA cap methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.591
EP300_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18994
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NUDUL1	CCLE Cell Line Gene Expression Profiles	1.0	1.4188
K562_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171616
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61844
PKBalpha_KO_GDS1784_196_mouse_Embryonic fibroblasts (MEFs) - 24h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2822
gland development	GO Biological Process Annotations 2015	1.0	null
BRD-K91235484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6253
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
osteoclastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.791877
proximity	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4769-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE103124_1_v_0_bmpr1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148643
B cell_Kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SNRPD1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314169
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9839
BRD-K63299069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08153
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
Nervous system development	Reactome Pathways 2024	1.0	null
EST1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K23591737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2142
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05255
BRD-K70875838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22228
BRD-K17956418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61442
GABP-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K85235446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53601
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351998
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22333
GLTSCR2	Pathway Commons Protein-Protein Interactions	1.0	null
NANOG-21062744-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12065
P-body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.435
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RUVBL1	Pathway Commons Protein-Protein Interactions	1.0	null
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.82808
Small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.886
ASH2L	Pathway Commons Protein-Protein Interactions	1.0	null
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40524
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17647
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4589
GTEX-PSDG-0926-SM-2I5FP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858829
K562_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182873
BRD-A60245366_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPRD1A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825851
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5834-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1083-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COR-L23	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.86424
BRD-K86867503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16793
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67495
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31538
BRD-K82935855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.741
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.4848
KMT2D	Pathway Commons Protein-Protein Interactions	1.0	null
Translation initiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.671
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.875
DDX42	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60507129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22468
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
MHHCALL3	CCLE Cell Line Gene Expression Profiles	1.0	2.0719
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.12651
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01477
BRD-K87929769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51762
BRD-K78262424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03123
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941003
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17979
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90356496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82494
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.035397
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.886087
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
FAM3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20371
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YW-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45248
Mebendazole_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0295278
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5702
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
CORL47	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64338
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8405
PGAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555814
MYO15B	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.03494
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087925
PBX3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068512
BET1	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA	Rummagene Transcription Factor Associations 2026	1.0	null
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305361
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0255712
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87359
triggers	GeneRIF Biological Term Annotations	1.0	null
Mucopolysaccharidosis I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K74817844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58771
SRF	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE185944_2_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
iec-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.463013
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE104604_1_v_0_eif5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.866
Monocrotaline_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0201088
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989791
ANAPC7	Pathway Commons Protein-Protein Interactions	1.0	null
K562_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205598
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX19B	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8092-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303239
K562_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216719
ITK_knockout_242_GSE12465	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.12108
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78337983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0571
MCF7_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153284
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18501
MINO	CCLE Cell Line Gene Expression Profiles	1.0	1.56413
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832808
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987303
STAT3	ENCODE Transcription Factor Targets	1.0	null
U2SURP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K82609503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06565
A549_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148184
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
regulatory	GeneRIF Biological Term Annotations	1.0	null
BRD-K63277230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21216
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
USP24	Pathway Commons Protein-Protein Interactions	1.0	null
PURA	Pathway Commons Protein-Protein Interactions	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nitrogen compound transport	GO Biological Process Annotations 2015	1.0	null
SRP68	Pathway Commons Protein-Protein Interactions	1.0	null
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6472
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.12088
RAD21	Pathway Commons Protein-Protein Interactions	1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320662
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56625
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56358
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	229.535
K562_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212339
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902132
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62763
SKMEL3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6386
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.75371
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33366
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
SACS	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.922187
ELF1	ENCODE Transcription Factor Targets	1.0	null
MAP2K4	Pathway Commons Protein-Protein Interactions	1.0	null
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217568
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060849
C2C12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.354
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.14504
EIF2S2	Pathway Commons Protein-Protein Interactions	1.0	null
GEMIN4	Pathway Commons Protein-Protein Interactions	1.0	null
STAG1	Pathway Commons Protein-Protein Interactions	1.0	null
ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.580922
RANGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172901
Brain Lower Grade Glioma_LGG_TCGA-HT-7473-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3702_KO_Hoxa2/Hoxb2_SRP051077	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.71443
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.49397
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Placenta	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.85286
HNRNPCL1	Pathway Commons Protein-Protein Interactions	1.0	null
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-3165	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
sertoli cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.231068
K562_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254841
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.537
GSPT1	Pathway Commons Protein-Protein Interactions	1.0	null
LY2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.806782
resolution	GeneRIF Biological Term Annotations	1.0	null
STAU1	Pathway Commons Protein-Protein Interactions	1.0	null
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19411393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45994
Atypical autism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.60596
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73297
promotes	GeneRIF Biological Term Annotations	1.0	null
BRD-K23956044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05712
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.088238
PAX5	ENCODE Transcription Factor Targets	1.0	null
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66952
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99356
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.8916
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19564
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.059995
Fatty Liver	CTD Gene-Disease Associations	1.0	1.43974
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238323
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8185-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29481
Sarcoma_SARC_TCGA-DX-A3U7-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9093
LC4-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.83858
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66746
mRNA transport	GO Biological Process Annotations 2025	1.0	null
DYNC1H1	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61431055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14203
K562_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168565
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.64752
FOXM1	ENCODE Transcription Factor Targets	1.0	null
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
SNAP29	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014985
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140906
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.10211
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38957
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91337
MLKL	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134128
CCT8	Pathway Commons Protein-Protein Interactions	1.0	null
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
mRNA_NANOG_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16386
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.959059
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12168
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
HNF4G	ENCODE Transcription Factor Targets	1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267511
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3353
CALCRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580231
TAF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00442272
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the skeletal system	GWASdb SNP-Phenotype Associations	1.0	0.049013
TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Nuclear speck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.179
osteosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083752
BRD-K70322385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0232
COPB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77150932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04271
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADNP-35650610-MESC-MOUSE-STEM-AUTISM	ChEA Transcription Factor Targets 2022	1.0	null
GTPBP4	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH196	CCLE Cell Line Gene CNV Profiles	1.0	1.60694
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.66059
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ELK1-19687146-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
RSRC2	Pathway Commons Protein-Protein Interactions	1.0	null
RPSA	Pathway Commons Protein-Protein Interactions	1.0	null
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MIF4G-like, type 3	InterPro Predicted Protein Domain Annotations	1.0	null
EFO-27	COSMIC Cell Line Gene Mutation Profiles	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155882
A549_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0277998
TTI1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151681
RELA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182727_1_v_0_busulfan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05918
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_5_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	-1.0	-1.15855
RAC3	Pathway Commons Protein-Protein Interactions	1.0	null
TE-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BL3513 (KDM4A)	NURSA Protein Complexes	1.0	null
BRD-K43989220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14138
MCF7_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019107
BRD-K17474512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71652
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Reactome Pathways 2024	1.0	null
MEF2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26093
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.44196
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25609
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.65167
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0588
Dom34-Hbs1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.767
BRD-K49669041_BX-912_MCF7_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K95500312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7432
HCC2279	CCLE Cell Line Gene Expression Profiles	-1.0	-2.26823
Nuclear dicing body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.84
CEBPB_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.328262
Sensillum trichodeum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.907
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66892
A549_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194639
DSP	Pathway Commons Protein-Protein Interactions	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.936714
CENPE	Pathway Commons Protein-Protein Interactions	1.0	null
Embryonic carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.324
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01722
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
alzheimer disease	GWASdb SNP-Phenotype Associations	1.0	0.43681
hela	GeneRIF Biological Term Annotations	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21985
hsa-miR-4525	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
YKG-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PPFIA1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
connective tissue disease	GWASdb SNP-Disease Associations	1.0	0.087642
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133329_2_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16114
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZMAT5	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of the prostate	GWASdb SNP-Phenotype Associations	1.0	1.0674
GOLGB1	Pathway Commons Protein-Protein Interactions	1.0	null
Ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.408
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EEFSEC	Pathway Commons Protein-Protein Interactions	1.0	null
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA3W-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926622
BRD-K48749255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24489
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-EGR1_DC_ChIP-seq_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.80066
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.780016
BRD-K12925598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29269
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18676
RNA export from nucleus	GO Biological Process Annotations 2025	1.0	null
HCC1833	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05975
SMG5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POYW-0426-SM-2XCEV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834275
Perturb_17278_KO_Upf2_SRP038144	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
8842_TFCP2L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544753
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE108500_1_v_0_foxp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160342
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10383
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.021
MCF7_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0276921
Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE1551	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.69621
BRD-K71726959_N9-isoproplyolomoucine_HA1E_6.0_h_122.55_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.93148
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXO1-25302145-T-LYMPHOCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A36630025_-666_RKO_6.0_h_0.34999999404_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188277
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.92808
PWP1	Pathway Commons Protein-Protein Interactions	1.0	null
Asciminib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0141301
MHH-PREB-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.81182
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.588456
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924665
SU-DHL-4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.76155
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Congenital heart defects, hamartomas of tongue, and polysyndactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
MAZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96194
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2144
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169385
BRD-K07276273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0584
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
Ebolavirus(EBOV)_2day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.61741
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-1245b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE196117_6_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166315_2_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SPEN	Pathway Commons Protein-Protein Interactions	1.0	null
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239566
Vitamin K4_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0300468
HT29	CCLE Cell Line Gene Expression Profiles	1.0	2.28331
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
atrophy/degeneration affecting the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.689348
Colo-320 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.687
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAPG	Pathway Commons Protein-Protein Interactions	1.0	null
FIP1L1	Pathway Commons Protein-Protein Interactions	1.0	null
CASC3	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7576-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134005
GSE213228_1_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26079895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53422
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.570496
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168227
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.42238
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8098-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154249
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.30026
GTEX-XUJ4-0326-SM-4BOP9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963173
Lung squamous cell carcinoma_LUSC_TCGA-94-7557-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376727
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BUB1	Pathway Commons Protein-Protein Interactions	1.0	null
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054001
BRD-K19237647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05868
NCI-H1048	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_UNC1999_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138819
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
MCF7_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228334
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-GH-A9DA-01A-21R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77869482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0577
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50509
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K98961458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38724
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K87884409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87268
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7518_KD_TRDMT1_SRP217219	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
COX6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35834
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997196
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Polysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.205
SHOC2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44664883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20437
Cervical adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.204
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
cytosol	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MKI67	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.4369
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A673	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.23475
HCV JFH-1_12Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.69368
uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.493745
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-203	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07008
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-103a	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gp2d	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.57
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12343256_trametinib_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55336
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LB373-MEL-D	GDSC Cell Line Gene Expression Profiles	-1.0	-2.33313
BRD-K98201103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75466
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.28416
Prostate adenocarcinoma_PRAD_TCGA-J4-8198-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36458
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183491
MCF7_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0248649
SLC12A9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718938
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.89762
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140832
PMC10290283-biol-2022-0622-sm3.pdf-223-ZNF576_ZNF576	Rummagene Transcription Factor Associations 2026	1.0	null
EIF2S3	Pathway Commons Protein-Protein Interactions	1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.8516
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65481
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12987
CRCGN014_HEPG2_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66983
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TM31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56452
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.2795
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55696337_topotecan hcl_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cortico-medial group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.891889
TK10	BioGPS Cell Line Gene Expression Profiles	1.0	1.08071
BRD-K80888628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44514
BRD-K49371609_528116.cdx_HT29_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bardet-Biedl syndrome 15	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
GSE242199_2_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ANXA11	Pathway Commons Protein-Protein Interactions	1.0	null
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.963803
A549_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151794
59M	CCLE Cell Line Gene CNV Profiles	1.0	1.59785
K562_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180474
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.756872
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13078
metabolic process	GO Biological Process Annotations 2015	1.0	null
MCF7_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169537
frb	GeneRIF Biological Term Annotations	1.0	null
LGR4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CDK12	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4782-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
RNAi effector complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.356
BRD-K61973443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05407
TE-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061953
Rhabdomyosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
BRD-K53293966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26199
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17337
SMG7	Pathway Commons Protein-Protein Interactions	1.0	null
UPF3A	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2936-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07073
EIF1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184622
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0972
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07964
PMC7391703-13059_2020_1979_MOESM1_ESM.xlsx-S4_DE_gene_after_KD-Table_S4_DE_gene_after_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bind	GeneRIF Biological Term Annotations	1.0	null
SRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164646
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bone inflammation disease	GWASdb SNP-Disease Associations	1.0	0.218269
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
tight	GeneRIF Biological Term Annotations	1.0	null
RAVER1	Pathway Commons Protein-Protein Interactions	1.0	null
NPRL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08619
SP1	ENCODE Transcription Factor Targets	1.0	null
GNL3L	Pathway Commons Protein-Protein Interactions	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
Artemether_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0284096
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.72316
ATF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_20_OE_Smarca5_SRP217699	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.27478
RQC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.289
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
Cytoplasmic ribonucleoprotein granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05569
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137438
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560151
ZNF326	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K27953820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31577
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32666
periosteum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.140393
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00298
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
BRD-K78659596_MLN2238_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939241
module	GeneRIF Biological Term Annotations	1.0	null
BRD-K11342801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53696
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30674
GSE146982_4_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TNRC6C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K81200901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4643
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083562
GSE223008_5_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DYNLL2	Pathway Commons Protein-Protein Interactions	1.0	null
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.969879
SF3B2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K79954583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01161
U2 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.399
MCF7_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148323
Prostate adenocarcinoma_PRAD_TCGA-WW-A8ZI-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIX5	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7866-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.121738
MYL12A	Pathway Commons Protein-Protein Interactions	1.0	null
KDM2B-26808549-CHIP-SEQ-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
EM-2	GDSC Cell Line Gene Expression Profiles	1.0	1.6425
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-138	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE206516,GSE206518_2_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2542
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4621
NACA	Pathway Commons Protein-Protein Interactions	1.0	null
SF3B4	Pathway Commons Protein-Protein Interactions	1.0	null
Vesiculobullous skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
BRD-K36644177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26893
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.849
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223673
PUM1	Pathway Commons Protein-Protein Interactions	1.0	null
MAP2K2	Pathway Commons Protein-Protein Interactions	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.91936
K562_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154754
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1529
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
ORC3	Pathway Commons Protein-Protein Interactions	1.0	null
BD-22-KS33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21913
PMC6683136-41598_2019_47363_MOESM2_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1-AS1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE220806_1_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_4_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155752
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06613
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386729
BRD-K57732605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09762
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951044
PSMC6	Pathway Commons Protein-Protein Interactions	1.0	null
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00141
hsa-miR-302f	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217762
K562_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168319
BRD-K72833997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02243
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Amp_AA-TCGA-Unnamed_17_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K14207150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31491
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
Glume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
A549_FLLL32_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130429
PMC6694122-41467_2019_11591_MOESM7_ESM.xlsx-f_CEBPA_DEGs-Gene_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235105
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.839901
abnormality of male internal genitalia	GWASdb SNP-Phenotype Associations	1.0	1.0674
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Caryopsis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.226
K562_SGI-1776 free base_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255189
CALR	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8973_KD_RBL1_SRP218370	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.33217
CDC16	Pathway Commons Protein-Protein Interactions	1.0	null
amyotrophic lateral sclerosis;	GAD Gene-Disease Associations	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91924
PMC3704444__F1	PFOCR Pathway Figure Associations 2023	1.0	null
MIF4-like, type 1/2/3	InterPro Predicted Protein Domain Annotations	1.0	null
FASN	Pathway Commons Protein-Protein Interactions	1.0	null
DIAPH3	Pathway Commons Protein-Protein Interactions	1.0	null
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31462
GTEX-WFON-1126-SM-4LVMA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859891
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4W0-05A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72098698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08777
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR3C1_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2238
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4410-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QG-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BABAM1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7984428__F2	PFOCR Pathway Figure Associations 2024	1.0	null
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
ITPK1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4118
Large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.665
Uterine leiomyoma_Uterus_GSE2725	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.63312
LF2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
XBP1_OE_GDS5065_273_mouse_F424a adipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BL7558 (UPF1)	NURSA Protein Complexes	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USO1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6092
BRD-K47471281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0158
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rna transport	GO Biological Process Annotations 2015	1.0	null
methyl-salicylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51688
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173575
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.02101
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HBS1L	Pathway Commons Protein-Protein Interactions	1.0	null
Diffuse gastric cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26952
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K17210248_S1216_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hydroxyurea_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0126874
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NRF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RHEB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93059
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.0539
GTEX-U3ZM-0226-SM-4DXTA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832731
NUDT21	Pathway Commons Protein-Protein Interactions	1.0	null
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.549423
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
K562_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268268
Telomerase holoenzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.061
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC7064337-elife-51373-supp2.xlsx-847_genes_down-regulated-List_of_847_genes_down-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Alisertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186159
TNPO2	Pathway Commons Protein-Protein Interactions	1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2983-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATXN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20116
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04974
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
DNA polymerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.658
PUF60	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IKZF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.31013
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	1.36409
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TERF2	Pathway Commons Protein-Protein Interactions	1.0	null
19218430-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XUW1-1526-SM-4BOOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01081
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00943
pc3	HPA Cell Line Gene Expression Profiles	-1.0	-0.937267
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08625
P4HA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00354689
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054757
SUZ12-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QEL4-0326-SM-3GAE5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906605
CYBA	Pathway Commons Protein-Protein Interactions	1.0	null
RBBP4	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160101
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.502678
BRD-K67460571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74667
ETV6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17729
CRCGN008_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8508
BRD-K35625946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69373
BRD-K36099605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43891
hsa-miR-576-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03742
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.17368
single-stranded DNA-binding protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.809
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583771
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2393
Metaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
MCF7_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150886
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.80894
BRD-K70945620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2443
BRD-K12879624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14073
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.595948
prostate cancer	GWASdb SNP-Disease Associations	1.0	1.21996
OMC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OLA1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271084
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.131313
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	1.08958
K562_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176874
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5522-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897848
Perturb_14225_KO_Tcf12_SRP392331	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.54088
U937_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.14144
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5454-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
close	GeneRIF Biological Term Annotations	1.0	null
BRD-K54272776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28012
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TSG101	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.735846
YKT6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7472
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10148
TC-69-EY43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201479
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2017
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87743
PMC3435504-msb201237-s2.xls-Supp_Table_4b-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NTRK2_drugactivation_66_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.6631
ZNF263	ENCODE Transcription Factor Targets	1.0	null
K562_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150996
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW-18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NUDC	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153999
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048549
Monocrotaline_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00994099
U2AF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.444
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00965
fao cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.796458
ZFP281-27345836-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72681
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96506
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1906
TNFSF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20535
HSPA6	Pathway Commons Protein-Protein Interactions	1.0	null
PICALM	Pathway Commons Protein-Protein Interactions	1.0	null
4299_KCNMB3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.577408
GTEX-U3ZN-2526-SM-3DB7V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39349
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7839-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30467307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23793
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18338
Prostate adenocarcinoma_PRAD_TCGA-EJ-7781-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AR	ChEA Transcription Factor Targets	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24538
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05379
BRD-K48129913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04661
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE253056_0_v_1_erythropoietin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97878
BRD-K27726273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83545
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TUBB2A	Pathway Commons Protein-Protein Interactions	1.0	null
ETS2_KD_GSE62168_258_mouse_mouse trophoblast stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843415
MPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21254
hsa-miR-4778-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CDK1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7628
TMCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38973
Idoxuridine_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208657
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72542
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null
GULP1	Pathway Commons Protein-Protein Interactions	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
K562_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189588
BRD-K19502817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30251
protein complex	GO Cellular Component Annotations 2015	1.0	null
prostate cancer	GWASdb SNP-Phenotype Associations	1.0	1.0674
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	138.887
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30679
hsa-miR-587	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76995
TRIM33	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155033
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.310421
ERBB2_knockdown_238_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.42468
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.908848
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
SMARCE1	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.042186
K562_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020886
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81779733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09625
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RNA nuclear export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.233
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9018
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4TF-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.100073
RISC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.335
TAOK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501702
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-HBP1_mod_HBP1	Rummagene Transcription Factor Associations 2026	1.0	null
NY	GDSC Cell Line Gene Expression Profiles	1.0	1.74396
organic cyclic compound catabolic process	GO Biological Process Annotations 2015	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3744
BRD-K84048601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09632
superior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.9574
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KIAA1279	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-0526-SM-4BRWD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90251
GTF3C5	Pathway Commons Protein-Protein Interactions	1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16241
Perturb_14224_KO_Tcf12_SRP392331	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.6505
OCIM1	CCLE Cell Line Gene Expression Profiles	1.0	2.30201
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971879
outer CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11509
HOXC8	Pathway Commons Protein-Protein Interactions	1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoplasmic ribonucleoprotein granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.126164
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52545
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55646
SNRPD3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K10812033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09595
NBN	Pathway Commons Protein-Protein Interactions	1.0	null
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.29
BRD-K82068522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02068
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SSUH2	Pathway Commons Protein-Protein Interactions	1.0	null
cingulate gyrus, parietal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.827055
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1894
thymus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.18201
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12145
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80689
A549_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106128
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HIP1R	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SF-1026-SM-4AD4I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931157
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230382
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13233
CLINT1	Pathway Commons Protein-Protein Interactions	1.0	null
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.889531
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M9-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
496100601_TCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.86035
NSUN5	Pathway Commons Protein-Protein Interactions	1.0	null
C11orf73	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24532680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17498
MHH-PREB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.885948
FERMT1	Pathway Commons Protein-Protein Interactions	1.0	null
TRIM65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45426
K562_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183905
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.55431
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
developmental process	GO Biological Process Annotations 2015	1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Antennal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.54
GTEX-XOTO-2126-SM-4B64U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05947
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856564
Beta thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.62
A549_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179132
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00178
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52714
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217732
BRD-K64356525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63331
RAB1A	Pathway Commons Protein-Protein Interactions	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF12	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6635
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.91296
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.524
BRD-K21997380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53238
TAL1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
TWF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K10911459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24574
PAK1	Pathway Commons Protein-Protein Interactions	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74628
KRT5	Pathway Commons Protein-Protein Interactions	1.0	null
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.507
K562_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163208
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
Protonema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.53235
TF	Pathway Commons Protein-Protein Interactions	1.0	null
PPP2R1B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TMMY-0626-SM-33HBD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990415
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41511
NF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40164971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39226
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_U937_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238177
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SSRP1	Pathway Commons Protein-Protein Interactions	1.0	null
TIAL1	Pathway Commons Protein-Protein Interactions	1.0	null
HAUS7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K16247913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3672
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18615
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.774739
PPP1R1A_KO_GDS1920_708_mouse_hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
K562_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173779
TRRAP	Pathway Commons Protein-Protein Interactions	1.0	null
JK1	CCLE Cell Line Gene Expression Profiles	1.0	2.40353
hsa-miR-3613-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsf1_17216044_hela_lof_human_gpl571_gds1733	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.392245
BICR18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4088
GSE182180_1_v_2_secretin_human	RummaGEO Drug Perturbation Signatures	1.0	null
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081815
K562_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186957
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08717
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GATA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31521
hemorrhagic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.192031
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EXOC5	Pathway Commons Protein-Protein Interactions	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.651734
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.56419
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7254-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Panicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CASC5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K90887068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54164
PMC10617732-pgen.1010988.s017.xlsx-Enrichments_Fig_5_S11_A-ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
STAT3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
region	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.4659
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64404
NFF	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.868645
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.09195
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.06585
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53493
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_ATF1-gene_ATF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.57049
HCC2279	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37012
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PTK7_knockdown_185_GSE50138	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.26773
K562_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179322
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56424158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30357
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
lm7	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924526
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.76881
BRD-K15615178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86305
COLO792	CCLE Cell Line Gene Expression Profiles	-1.0	-2.45272
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.494
URB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86701
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851459
K562_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120726
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510661
MCF7_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115975
Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.32577
HSPA12A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14259
CPSF3	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154761
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KAT2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95657
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hs-683	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.91285
K562_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129358
DSH1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EBNA1BP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A52530684_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.80066
BRD-K24711162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88618
nucleolar part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.24424
Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01549	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.967041
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.45111
Up-frameshift suppressor 2	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73002
COVID 19 structural coverage map	WikiPathways Pathways 2024	1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.288
monocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.108871
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.76977
BRD-K77609086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0428
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	2.45792
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCAR5	CCLE Cell Line Gene CNV Profiles	1.0	1.81061
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43919
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.65189
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062097
IRF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23932
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
key	GeneRIF Biological Term Annotations	1.0	null
DTYMK	Pathway Commons Protein-Protein Interactions	1.0	null
490_ARID3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.570636
SARS-BatSRBD_0Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.66646
BRD-K52154207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38994
TAL1	ENCODE Transcription Factor Targets	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
organic substance transport	GO Biological Process Annotations 2015	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
helicase	GeneRIF Biological Term Annotations	1.0	null
cellular nitrogen compound catabolic process	GO Biological Process Annotations 2015	1.0	null
hydrocotarnine-1772	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF7_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162293
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20096
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06364
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIK3R4	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3031
BRD-K81960205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0991
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31519
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929163
SPHK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32899
Viral assembly intermediate	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.838
BRD-K31526203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23119
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Noonan syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
VPS36	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.48173
PMC11327330-41467_2024_51380_MOESM4_ESM.xlsx-supfig05f-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TRAMP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.114
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.694
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4639-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99252563_QL-XII-47_SKBR3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K97761115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54294
A549_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145558
crucial	GeneRIF Biological Term Annotations	1.0	null
HBB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165969
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.775
BRD-K41690760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84829
BRD-K99412981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5962
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
BRD-K04005364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20669
CEBPD	ENCODE Transcription Factor Targets	1.0	null
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989332
PRDM16-22522345-PALATE_MESENCHYMAL-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K04628654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92842
AF-72-PP21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206586
a94	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
Methotrexate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0103567
BRD-K83751422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06622
small_intestine	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.83743
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.28497
S-117	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08061
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDM1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF2	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20622
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
Depression_Cerebral cortex_GSE12654	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.96192
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38624
TD-29-IN36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228653
complete embryonic lethality	MPO Gene-Phenotype Associations	1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19907
JARID1B-DAIN-22020125-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225249
NCIH2110	CCLE Cell Line Gene CNV Profiles	1.0	1.35848
LXF-289	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H520	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204733
K562_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0448263
GSE168097_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MED12L	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
A549_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181821
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98681
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34341
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.306083
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925574
SKMEL31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54823
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.92205
BLM	Pathway Commons Protein-Protein Interactions	1.0	null
THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.237
NELFCD	Pathway Commons Protein-Protein Interactions	1.0	null
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25631
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27482
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1169
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.158849
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
DMS454	CCLE Cell Line Gene Expression Profiles	-1.0	-2.21908
BRD-K77101974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87407
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.855
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5356-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTEN_KD_GDS2958_99_human_A431 - EPIDERMOID carcinoma cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
EIF4A3	Pathway Commons Protein-Protein Interactions	1.0	null
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
SRF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33852
c6 glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.793126
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Voriconazole_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0209036
CRCGN011_HEPG2_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0835
USF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168763
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146687_2_v_3_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120061
YY1	Pathway Commons Protein-Protein Interactions	1.0	null
5-Azacytidine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188033
NCOA2_KO_GDS4785_172_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.142
IB-67-WH43_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202677
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.934992
NCIH1930	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62977
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
LSM2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7177
BRD-A98888138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75253
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28077
Hypnozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.653
BRD-K89471250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46559
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.501
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938181
causing	GeneRIF Biological Term Annotations	1.0	null
A549_Fasudil_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184934
PMC7320752__F6	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32552
Lung adenocarcinoma_LUAD_TCGA-86-7713-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0331944
H2BK15ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173876
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414954
RBMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98505
K562_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170082
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAF-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.575
LXF-289	GDSC Cell Line Gene Expression Profiles	1.0	1.58368
CRCGN015_MCF10A.TP53.M_24H:C05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06972
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254998
BRD-K01615696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50885
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.193
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
PMC7984428__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC9691391-7945884.f3.pdf-41-ENSG00000166261_ZNF202	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3129-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15151
rna binding	GO Molecular Function Annotations 2015	1.0	null
LENG1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE139325_0_v_3_cd36_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0348407
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.913248
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HN-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.9788
BRD-K93374700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.66152
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36757
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07832
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69715817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69225
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.4141
WRNIP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167198
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
S2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.388
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.899711
BRD-K94409042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7352
BRD-K53612668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2409
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05948
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05589
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JA-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNPO1	Pathway Commons Protein-Protein Interactions	1.0	null
STS-0421	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.88832
GTEX-X4XX-0926-SM-46MV7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888408
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K61868194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07365
FHOD1	Pathway Commons Protein-Protein Interactions	1.0	null
COPS6	Pathway Commons Protein-Protein Interactions	1.0	null
cbp80	GeneRIF Biological Term Annotations	1.0	null
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0132
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04546974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26747
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.20601
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMG1	Pathway Commons Protein-Protein Interactions	1.0	null
SF3A1	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenosquamous carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.441
RBM14	Pathway Commons Protein-Protein Interactions	1.0	null
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Postsplicing complex	CORUM Protein Complexes	1.0	null
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.058564
BRD-K13445266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02018
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150306
MCF7_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190134
organelle	GO Cellular Component Annotations 2015	1.0	null
BRD-K48540267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28688
CRCGN010_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01056
SCHNEIDER-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.064
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43511
nuclear-transcribed mRNA catabolic process	GO Biological Process Annotations 2025	1.0	null
TGFBR1_activemutant_291_GSE14523	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.4154
A549_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223186
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
termination	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_NCIH1836_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	177.78
HOP62	BioGPS Cell Line Gene Expression Profiles	1.0	0.973217
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.07447
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.49247
cancer	GWASdb SNP-Disease Associations	1.0	0.051103
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stimulate	GeneRIF Biological Term Annotations	1.0	null
Gene Expression	Reactome Pathways 2014	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
extensively	GeneRIF Biological Term Annotations	1.0	null
BRD-A62184259_Cycloheximide_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nuclear export	GO Biological Process Annotations 2015	1.0	null
9601_UPF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.577788
BRCA1	ENCODE Transcription Factor Targets	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KO-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.60554
GTEX-T6MN-0008-SM-4DM7H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910126
PRPF40A	Pathway Commons Protein-Protein Interactions	1.0	null
ENAH	Pathway Commons Protein-Protein Interactions	1.0	null
A549_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175055
Lung squamous cell carcinoma_LUSC_TCGA-77-8136-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A2M	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1068
Perturb_6298_KD_CGA_SRP355115	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32239
SNRPE	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K00631971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08048
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
K562_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265962
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.02447
single-organism developmental process	GO Biological Process Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1972
Ejaculatory duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.728
GTSE1	Pathway Commons Protein-Protein Interactions	1.0	null
HOXC9	Pathway Commons Protein-Protein Interactions	1.0	null
BCL3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09309
Embryonic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
SQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.91797
BRD-K72609445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18834
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Human immunodeficiency virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
Perturb_7032_KO_Firre_SRP076940	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.12615
Wing disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	1.0	null
Leukemia_promyelocytic-HL-60	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.866389
DIDO1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K99749624_linifanib_MCF7_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K84077642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71329
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99833695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05521
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-0.928454
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TOP3B	Pathway Commons Protein-Protein Interactions	1.0	null
cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058832
A549_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233713
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01838
Congenital muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
Metabolism of RNA	Reactome Pathways 2024	1.0	null
Calu-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.443
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.91566
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19797
SRP19	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Macronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.041
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MA-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
m86	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RN64-0626-SM-2TC5V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980035
BL7129 (CCDC124)	NURSA Protein Complexes	1.0	null
BRD-K09521953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29764
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.82
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080531
Perturb_11758_KO_Tlr3/Mavs_SRP114764	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.76139
K562_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241985
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03315
hsa-miR-493	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
YIPF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE228106_0_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRRM1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42253676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00418
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
EIF3G	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43375231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02137
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829509
BZW1	Pathway Commons Protein-Protein Interactions	1.0	null
CIZ1	Pathway Commons Protein-Protein Interactions	1.0	null
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.83013
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC73	Pathway Commons Protein-Protein Interactions	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
1747_COG8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.506231
Germ plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.309
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40524
brings	GeneRIF Biological Term Annotations	1.0	null
BRD-K64264263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09704
LU99	CCLE Cell Line Gene CNV Profiles	1.0	2.24267
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217762
MCF7_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227407
BRD-K91998226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56522
A549_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013885
Eukaryotic translation initiation factor 2B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.834
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.870484
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00477
GRK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545176
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139772
spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.304027
K562_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232261
K562_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152588
catalytic	GeneRIF Biological Term Annotations	1.0	null
RRP7A	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAGOH	Pathway Commons Protein-Protein Interactions	1.0	null
MYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01448
liver	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.22204
CRCGN013_HEPG2_24H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61239
K562_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016634
ZNF705B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58051
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27599
Amyotrophic Lateral Sclerosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSK3A_knockdown_205_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.85136
Salicylic acid_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0315501
NCI-H2023	COSMIC Cell Line Gene Mutation Profiles	1.0	null
496100635_HIP_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.50096
NIPBL	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175171
MAP2K3	Pathway Commons Protein-Protein Interactions	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054413
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.855688
UBL4A	Pathway Commons Protein-Protein Interactions	1.0	null
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
mRNA_DLX3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Sarcoma_SARC_TCGA-SG-A6Z4-01A-22R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82433264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13277
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877905
Perturb_378_KO_HDLBP_SRP261899	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.13329
ZBTB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41699
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0318338
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0092
HMT-3522 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.00766
OAW-28	GDSC Cell Line Gene Expression Profiles	-1.0	-1.78875
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293224
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.604473
Methylprednisolone succinate_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0122258
BRD-K64800655_HY-11001_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.969234
BRD-K51858914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85935
ACAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94268
G84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.932473
BRD-K89366259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75637
MCF7_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138962
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A8-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08879
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAOK1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0355716
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0320808
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40524
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IH-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2BK20ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05658
AP3B1	Pathway Commons Protein-Protein Interactions	1.0	null
BICR16	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66686
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202
BRD-A59985574_T542500_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE111247_14_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197975
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alzheimer Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
NCIH1930	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42013
KDM1A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WVLH-0011-R8A-SM-3MJFC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848847
PMC9314667-Table_1.xlsx-Regulons-IRF3_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67432
MET_knockout_261_GSE8747	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.69598
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23097
CCDC59	Pathway Commons Protein-Protein Interactions	1.0	null
SF3B5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19456
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.824
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.284728
BRD-K82764092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79407
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9919
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7299
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
STAT5A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157247
GSK3B_knockdown_206_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.64429
SMARCB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31780647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32929
FEN1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0325988
SNX2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219851
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875182
HIC2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05277255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15025
BRD-A02481876_Importazole_MCF7_24.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08955
A549_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180998
CCNB1	Pathway Commons Protein-Protein Interactions	1.0	null
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07988
Perturb_12952_KO_ZFP36L2_SRP251843	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.96521
MCF7_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174426
BRD-K49490091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9043
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.38747
PTCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36076
EWSR1	Pathway Commons Protein-Protein Interactions	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
GTEX-R53T-1626-SM-3GAEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851696
COL1A1	Pathway Commons Protein-Protein Interactions	1.0	null
NRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55124
KLM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2766
GTEX-OXRP-0326-SM-33HBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55016
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486874
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.507
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99251
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53346
HNRNPA3	Pathway Commons Protein-Protein Interactions	1.0	null
RMUGS	CCLE Cell Line Gene Expression Profiles	-1.0	-2.62884
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66016
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.22302
EPB41L3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A13122391_16-HYDROXYTRIPTOLIDE_HT29_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49393
BCL3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20498
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.703536
CRCGN016_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34084
nucleocytoplasmic transport	GO Biological Process Annotations 2015	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POMQ-2026-SM-2S1OD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24285
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68701
MCF7_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115297
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062317
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Axonal growth cone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.871
K562_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178516
GTEX-WVLH-0011-R7A-SM-3MJFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899209
DHX8	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE157594_5_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MARK2	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044702
PBX3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
APLP2_KO_GDS4414_371_mouse_prefrontal cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-SNOS-1726-SM-32PLN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846927
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
rheumatoid arthritis	GWASdb SNP-Phenotype Associations	1.0	0.488001
STAT1	ChEA Transcription Factor Targets	1.0	null
ITGB1	Pathway Commons Protein-Protein Interactions	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078697
PMC4975902-12864_2016_2842_MOESM12_ESM.xlsx-targets_of_IRF8_in_NSCLC-COX7C_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LV-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PSMC2	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40852
HLA-DRB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00485126
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29335
TCF3	ENCODE Transcription Factor Targets	1.0	null
HOXA9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.96266
16-HBE14o cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.952
A549_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136055
SNU1079_BILIARY_TRACT	CCLE Cell Line Proteomics	1.0	5.06156
PDCD7	Pathway Commons Protein-Protein Interactions	1.0	null
Finding Of Mean Corpuscular Hemoglobin	DisGeNET Gene-Phenotype Associations	1.0	null
RAB23	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.773174
MMS22L	Pathway Commons Protein-Protein Interactions	1.0	null
SK-GT-4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.01903
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3545
MORF4L1	Pathway Commons Protein-Protein Interactions	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K17482962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14048
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57437
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.6429
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
embryonic lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
RPS15	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CDC5L	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GNB3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34629
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889259
BRD-K99827210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20032
BRD-K32983008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74811
Prostate adenocarcinoma_PRAD_TCGA-HC-8266-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	1.8764
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.4788
TSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03097
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30964193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89858
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A2-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNUPN	Pathway Commons Protein-Protein Interactions	1.0	null
GSE211931_0_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
B-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.733
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
SRP54	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8972054-MSB-18-e10682-s002.xlsx-Dataset_EV11-Factor_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19216
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_PL21_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF7_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014479
Mobilized_CD34_Primary_Cells_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.64301
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33805386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36581
BRD-K64215924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23535
17183660-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059552
SETDB1	ENCODE Transcription Factor Targets	1.0	null
KHDRBS1	Pathway Commons Protein-Protein Interactions	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.85836
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4427-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.111
GTEX-PWOO-0726-SM-2I3EB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968515
Brain Lower Grade Glioma_LGG_TCGA-HT-7873-01B-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00737251
17009876-tableS1a	GeneSigDB Published Gene Signatures	1.0	null
Verteporfin_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216139
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
u698	HPA Cell Line Gene Expression Profiles	1.0	0.854637
MTA3	Pathway Commons Protein-Protein Interactions	1.0	null
Choroid plexus epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.766
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31395
K562_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195116
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.391994
GCIY	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.98514
ATPase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Prp19 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
mRNA export from nucleus	GO Biological Process Annotations 2023	1.0	null
HCC1500	CCLE Cell Line Gene CNV Profiles	1.0	1.41334
LMNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04136
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228007
KIF4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75219
BRD-K34262858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15463
RFX1	Pathway Commons Protein-Protein Interactions	1.0	null
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
C9-MEF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.243
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621581
BRD-K77903467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40704
Perturb_10005_KD_METAP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.84751
intestinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.354826
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.225969
RAD50	Pathway Commons Protein-Protein Interactions	1.0	null
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.1739
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Malignant tumor of pancreas_saliva_GSE14245	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.4163
GSE86507,GSE86509_7_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337598
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TM31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92099
GNA14	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0272896
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_118_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.979745
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OSC-20	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.26785
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194582
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241733
SMC4	Pathway Commons Protein-Protein Interactions	1.0	null
RP1_KO_GDS1845_190_mouse_Retinas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
K562_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0269718
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	339.636
PMC2976970__F3	PFOCR Pathway Figure Associations 2024	1.0	null
HT-29	GDSC Cell Line Gene Expression Profiles	1.0	3.31729
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.5065
oocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.919061
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCIH2141	CCLE Cell Line Gene CNV Profiles	-1.0	-3.15598
nucleobase-containing compound transport	GO Biological Process Annotations 2015	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256262
RUVBL2	Pathway Commons Protein-Protein Interactions	1.0	null
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085076
BRD-K14868348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54717
SMAD3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CNTROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44938
A549_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169452
H3K9ac_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825703
BRD-K91818277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39842
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1246
NCIH2066	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42547
ARID3A	ENCODE Transcription Factor Targets	1.0	null
BRD-K13526564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42245
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.61023
SRI	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO-792	GDSC Cell Line Gene Expression Profiles	-1.0	-1.96185
BRD-K26321439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7368
A549_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015397
ATP5ME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04065
sequence-specific DNA binding	GO Molecular Function Annotations 2023	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K57115335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47422
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41513047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43897
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.35036
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	2.8036
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222765
CBX3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Filgotinib_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0170042
VPS51	Pathway Commons Protein-Protein Interactions	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDH4-35650610-MESC-MOUSE-STEM-AUTISM	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CaR-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.70461
TSFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15393
HLTF	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.89534
GSE227634,GSE228381_0_v_5_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DNA polymerase III, clamp loader complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.689
GSE160083,GSE160084_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNX1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137888
A549_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151533
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tauopathy	GWASdb SNP-Disease Associations	1.0	0.511604
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8945030__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MYBBP1A	Pathway Commons Protein-Protein Interactions	1.0	null
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.040734
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87254
ARF5	Pathway Commons Protein-Protein Interactions	1.0	null
KASUMI1	CCLE Cell Line Gene Expression Profiles	1.0	2.04492
non-syndromic intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0456
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
MELK	Pathway Commons Protein-Protein Interactions	1.0	null
CTNND1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205639
KNS81	CCLE Cell Line Gene Expression Profiles	-1.0	-2.51971
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
RNPS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04011
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.72986
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5334-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136859
BRD-K85275903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06348
mRNA export from nucleus	GO Biological Process Annotations 2025	1.0	null
BRD-K58232861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21339
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40076
K562_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174229
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13556
Pulvinus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.373
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-885-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
EXOC4	Pathway Commons Protein-Protein Interactions	1.0	null
IRF4	ENCODE Transcription Factor Targets	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0264
Perturb_14660_KO_Insm1|Neurod1_ERP127840	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.6664
K562_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221038
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6505
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974981
UBE2M	Pathway Commons Protein-Protein Interactions	1.0	null
MYB	Pathway Commons Protein-Protein Interactions	1.0	null
ANXA7	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175993
TUBGCP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MO-0726-SM-4DM58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863917
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PAN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066674
Cancer of Colon_Intestine - Large Intestine - Colon (MMHCC)_GSE4107	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.72902
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RTCB	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_Activation - 4 hours_GDS2025_724_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276145
HCC70	CCLE Cell Line Gene CNV Profiles	1.0	2.69029
NCIH716	CCLE Cell Line Gene CNV Profiles	1.0	1.48568
BRD-K96218803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12493
BRD-K01980291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23341
hsa-miR-718	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.174093
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377382
Dehydration_Hypothalamus_GSE3125	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.87725
TRAF3IP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543884
MCF7_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274306
RFC3	Pathway Commons Protein-Protein Interactions	1.0	null
TOX4	Pathway Commons Protein-Protein Interactions	1.0	null
MEF2C_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WIZ	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.940885
YLPM1	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70530990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48828
A549_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219592
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.41
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5556
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
nucleic acid transport	GO Biological Process Annotations 2015	1.0	null
Auranofin_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0144926
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59252
ubiquitinproteasome	GeneRIF Biological Term Annotations	1.0	null
A549_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0291274
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04045
ENL-26711339-SEM-HUMAN-BLOOD-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GSE182680,GSE182683_0_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8145311__F7	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K66207462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43833
RPS3	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140315
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4330-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SDHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0262
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_TMP195_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134302
SRF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201738
MCF7_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164649
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832846
ELK4	ENCODE Transcription Factor Targets	1.0	null
dermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.114607
RPL7A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17979415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06664
Dcp1-Dcp2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.776
ID-96-UX79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307118
BRD-K31889353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00499
hsa-miR-4774-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41724
K562_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246408
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K69942587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12628
K562_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015346
MPP2	Pathway Commons Protein-Protein Interactions	1.0	null
subcallosal cingulate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34925
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.166753
inferior frontal gyrus, opercular part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.899079
abnormality of the male genitalia	GWASdb SNP-Phenotype Associations	1.0	0.271604
PBRM1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-0626-SM-4JBHN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31439
CNOT10	Pathway Commons Protein-Protein Interactions	1.0	null
LSM1	Pathway Commons Protein-Protein Interactions	1.0	null
VAT1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0279326
upf	GeneRIF Biological Term Annotations	1.0	null
SLR25	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66958
cooperatively	GeneRIF Biological Term Annotations	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K34335352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67542
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233959
KLM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64338
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65855
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.34576
17823660-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557423
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
liver development	GO Biological Process Annotations 2015	1.0	null
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5675
ELF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.10205
MYBL2	ENCODE Transcription Factor Targets	1.0	null
HCC1187	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.3841
TAL1_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39275
TOV-21G	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLT-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.69083
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93783
GTEX-WYVS-2526-SM-3NMAT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952423
Malignant mesothelioma of pleura_Pleura_GSE2549	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.48872
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_7_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Teratocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.111
NFIA_Deficiency_GDS2775_640_mouse_Postnatal brains (at P16)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
mrna transport	GO Biological Process Annotations 2015	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2787
ELK1	ENCODE Transcription Factor Targets	1.0	null
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146727
PPIL1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1882
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.31247
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1903
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64512
NCIH1618	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85159
BRD-K05228434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29242
MCF7_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216139
mrna metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC6224609-mmc4.csv--ENCODE_KD_Experiments_Accesion_Number_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ORC2	Pathway Commons Protein-Protein Interactions	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Eukaryotic translation initiation factor 4F complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.523
hsa-miR-3135b	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
hsa-miR-548p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
ACTR1A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nuclear-transcribed mrna catabolic process, nonsense-mediated decay	GO Biological Process Annotations 2015	1.0	null
BL7683 (RNASEN)	NURSA Protein Complexes	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149288
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02742
Ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.984
BRD-K47348275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69379
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
CAL-78	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTF3C1	Pathway Commons Protein-Protein Interactions	1.0	null
THP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60263
MS (Multiple Sclerosis)_CNS - Spinal Cord (MMHCC)_GSE842	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.75459
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-HBP1_mod_HBP1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4738-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
A549_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192972
GTEX-S4Q7-0226-SM-4AD5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957483
TAF9	Pathway Commons Protein-Protein Interactions	1.0	null
MOLP-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.72294
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7320752__F6	PFOCR Pathway Figure Associations 2024	1.0	null
NOMO1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19689
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989552
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04679
POU2F2	ENCODE Transcription Factor Targets	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827052
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mrna export from nucleus	GO Biological Process Annotations 2015	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cortico-medial group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31326
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840355
IKBKG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512955
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
HDLBP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92812209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57314
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889899
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12732
BCAS2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44509164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2652
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.538
SF126	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.96789
Ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.421
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K09337184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1587
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.42
TAF1	ENCODE Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46019
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12156
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K74767736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29303
HARA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22195
Prostate adenocarcinoma_PRAD_TCGA-HC-A632-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCAPG	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5494-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
exon-exon junction complex	GO Cellular Component Annotations 2015	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268119
SMARCA5	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155704
no-11	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.25593
K562_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0472402
FAM129B	Pathway Commons Protein-Protein Interactions	1.0	null
Nimesulide_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268541
CD81	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044191
CREM	ChEA Transcription Factor Targets	1.0	null
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.81819
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.830593
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.62106
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A1A1-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTPS1	Pathway Commons Protein-Protein Interactions	1.0	null
RH-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AQP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00780453
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.523241
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05573
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1	Rummagene Transcription Factor Associations 2026	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226093
Female pudendum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.343
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36756
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perisynaptic extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.994
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01739
Spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.648
BRD-K56531121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02764
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7719
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K86897283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01588
system	GeneRIF Biological Term Annotations	1.0	null
BL6090 (PHC3)	NURSA Protein Complexes	1.0	null
MCF7_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169195
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.20946
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32562
TP63	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60661821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14365
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZT-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.068535
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.903
SOD2_KO_GDS1080_128_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GPR87	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00610286
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055738
ANAPC1	Pathway Commons Protein-Protein Interactions	1.0	null
NR2F2	Pathway Commons Protein-Protein Interactions	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40565784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11981
BUB1B	Pathway Commons Protein-Protein Interactions	1.0	null
ARL1	Pathway Commons Protein-Protein Interactions	1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23499
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14963
EPHB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00459577
BRD-K18313650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09719
Female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
BRD-K48263613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26646
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CDC23	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164167
BRD-K89277562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58174
mono-mac-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.7105
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85299
SRSF5	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-7656-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873525
LSM14A	Pathway Commons Protein-Protein Interactions	1.0	null
Secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
hsa-miR-635	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
MAP1LC3B	Pathway Commons Protein-Protein Interactions	1.0	null
RPL36	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4674	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
APLP2_KO_GDS4414_534_mouse_adult cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Epidermolysis bullosa dystrophica	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
MCF7_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125239
mRNA cleavage and polyadenylation specificity factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.737
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190305
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201433
CRCGN015_MCF10A_48H:E15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15609
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
GABP-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.912301
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59419
LSM1	Hub Proteins Protein-Protein Interactions	1.0	null
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.05015
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41199
NR3C1_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06313
protein binding	GO Molecular Function Annotations 2015	1.0	null
NUP153	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nidopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11878
DAZAP1	Pathway Commons Protein-Protein Interactions	1.0	null
NCC021	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.89691
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34905
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ribonucleoprotein granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03813
Acute Myeloid Leukemia_LAML_TCGA-AB-2814-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NALM1	CCLE Cell Line Gene Expression Profiles	1.0	1.58337
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08425
CUL2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
arthritis	GWASdb SNP-Disease Associations	1.0	0.250091
Ullrich congenital muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.444
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3657	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IM-95	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTNNA1	Pathway Commons Protein-Protein Interactions	1.0	null
Schizozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.2079
Nuclear RNA export factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.194
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18876
blood platelet disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.23666
BRD-K11636097_S1249_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE138945,GSE138947_0_v_1_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K78169765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11859
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.028163
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31113
SUPT16H	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07870648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24623
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219067
Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spleen-memory b cell	Tabula Sapiens Gene-Cell Associations	1.0	4.31815
PRPF31	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85517
BRD-K40923781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04413
Protein phosphatase type 2A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.838
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.137
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179002_0_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97935314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15581
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.8294
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE126776_0_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211215_1_v_0_akr1b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19719
PSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24205
BRD-K96945047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80405
CAMSAP3	Pathway Commons Protein-Protein Interactions	1.0	null
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308974
hsa-miR-494	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
YEATS4	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6823-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA MB435	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.48871
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRT6C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K38519585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05643
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11809
Multilymphoid progenitor cell_Umbilical cord blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19537
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.685
BRD-K83670234_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Keratohyalin granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.501
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
prostate neoplasm	GWASdb SNP-Phenotype Associations	1.0	1.0674
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941003
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.00252
subcuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.843665
Perturb_8836_KO_METTL3/METTL14_SRP356709	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.35119
SNX3	Pathway Commons Protein-Protein Interactions	1.0	null
MED4	Pathway Commons Protein-Protein Interactions	1.0	null
ECHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04872
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881045
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64623
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
icSARS CoV_12Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.78132
MED30	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.996737
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157459
Histone mRNA stem-loop binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.129
transport	GO Biological Process Annotations 2015	1.0	null
Auranofin_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0223695
BRD-K28433349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59918
SERINC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2032
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37819
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022115
subcallosal cingulate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23753
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17496
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5441-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
APBB1IP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K50133846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02051
BRD-K53943097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29634
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.02792
K562_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015648
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.113621
GTEX-N7MS-2326-SM-2HMLD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852194
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A4S6-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08898
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4748
Macitentan_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.028044
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.27503
BRD-K58836556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34641
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.33063
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78741
PMC12229841-Table2.xlsx-6mo_NS_vs_6mo_LPS-Negative_logFC_up_at_non-stimulated_Postive_logFC_up_after_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Chromatoid body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.895
(R)-Verapamil (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0128669
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51299
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00519
FAF1	Pathway Commons Protein-Protein Interactions	1.0	null
Exoribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.825
UACC893	CCLE Cell Line Gene CNV Profiles	1.0	1.56368
CMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
propose	GeneRIF Biological Term Annotations	1.0	null
UMPS	Pathway Commons Protein-Protein Interactions	1.0	null
YME1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568185
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU1J-1926-SM-2TF6S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10225
K562_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192477
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02419
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.85603
K562_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236462
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6673
CAMKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65523
Daoy	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.22931
MM1S	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
MCF7_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146884
GTEX-R3RS-0726-SM-3GIJR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03635
GTEX-XMK1-0226-SM-4B65D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874042
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	1.0	0.963589
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
Floor plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.227
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01793
NRF1	JASPAR Predicted Transcription Factor Targets	1.0	null
anatomical structure development	GO Biological Process Annotations 2015	1.0	null
mn60	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.635
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86057
BRD-K26431593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.61278
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4699-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155443
KLF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12685
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04782
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MEF2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6478_OE_YAP1_SRP111293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.84454
IQGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03115
17210682-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
MED8	Pathway Commons Protein-Protein Interactions	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.114
SRF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-3 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.950689
MCF7_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199191
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35889
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Pexidartinib (hydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188293
Perturb_12106_KO_Fcgr2b_SRP326159	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.69026
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNAPC4	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17379
Perturb_13251_KO_Dux_SRP098643	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.49916
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60477
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.830371
ERCC1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5277-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31157
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96865
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.6014
GP1BB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617471
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88394
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202862
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CCDC141	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558185
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.858517
PAK4	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15072
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150738
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81757081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02209
MCF7_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141362
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963944
Betamethasone dipropionate_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00962556
PIK3CA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640348
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218334
Brain Lower Grade Glioma_LGG_TCGA-HW-7493-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WDR33	Pathway Commons Protein-Protein Interactions	1.0	null
mRNA_TCEA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.120052
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RALY	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23063
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
UBE2Q1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MARCKS	Pathway Commons Protein-Protein Interactions	1.0	null
PHB2	Pathway Commons Protein-Protein Interactions	1.0	null
UCHL5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13076765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03301
ASUN	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.66717
POLR2A	ENCODE Transcription Factor Targets	1.0	null
FLNC	Pathway Commons Protein-Protein Interactions	1.0	null
Doxycycline (monohydrate)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0255101
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.99
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.06859
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14504
A549_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160363
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.11074
BAIAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26168
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.830036
Lung squamous cell carcinoma_LUSC_TCGA-77-8143-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TF1	CCLE Cell Line Gene Expression Profiles	1.0	2.48595
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
motor neuron atrophy	GWASdb SNP-Phenotype Associations	1.0	0.689348
HNFA-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918721
RNPC3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K96663576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57417
COA5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95251122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26375
K562_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267202
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374425
hsa-miR-1253	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47754
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40656
MCF7_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153488
SMG9	Pathway Commons Protein-Protein Interactions	1.0	null
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.40541
NEFM	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09567
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09812
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966455
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40630587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02346
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
SFI1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130236
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.842154
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073583
OCI-AML5	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.36663
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.886087
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RENT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.299
DOCK1	Pathway Commons Protein-Protein Interactions	1.0	null
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052623
BRD-K95153427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01068
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LMNA	Pathway Commons Protein-Protein Interactions	1.0	null
SH10TC	CCLE Cell Line Gene CNV Profiles	1.0	1.43146
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.997914
BL3837 (KDM5A)	NURSA Protein Complexes	1.0	null
exonjunction	GeneRIF Biological Term Annotations	1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.688478
HSC-39	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14396
RPS27	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A26002865_V4877_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1391_CDC23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50943
BRD-K43389675_DAUNORUBICIN_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-762	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
PFKM	Pathway Commons Protein-Protein Interactions	1.0	null
sequence-specific DNA binding	GO Molecular Function Annotations 2025	1.0	null
ROR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22728
K562_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206609
U2AF2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2023	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RABAC1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.903661
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51642
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05102
skeletal muscle cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061686
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TUBGCP4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057126
BRD-K78659596_MLN2238_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88150784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23881
striatum_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09289
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16232
RPS6	Pathway Commons Protein-Protein Interactions	1.0	null
DIPK2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20165
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21562
GSE144231_6_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152524
SF3A3	Pathway Commons Protein-Protein Interactions	1.0	null
PSMC1	Pathway Commons Protein-Protein Interactions	1.0	null
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_TMP195_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153701
THAP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A44068497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81441
FXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30147
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13216
kinase	GeneRIF Biological Term Annotations	1.0	null
Scrapie	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
BRD-K73497584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64491
Perturb_5043_KO_Adnp_SRP313259	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.4864
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884889
CA46	CCLE Cell Line Gene Expression Profiles	1.0	1.3782
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
EXOC7	Pathway Commons Protein-Protein Interactions	1.0	null
ND-85-OJ63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214046
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.67783
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.85731
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5166
FLI1	ChEA Transcription Factor Targets	1.0	null
K562_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223998
abnormal motor neuron morphology	GWASdb SNP-Phenotype Associations	1.0	0.689348
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K39227064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05412
SNU475	CCLE Cell Line Gene CNV Profiles	1.0	1.41032
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13938
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IPO9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K88281646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30971
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-U33728988_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72224143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38927
SNU626	CCLE Cell Line Gene Expression Profiles	-1.0	-3.00582
conformational	GeneRIF Biological Term Annotations	1.0	null
ADNP	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171653
SPATA5L1	Pathway Commons Protein-Protein Interactions	1.0	null
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K34620971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23528
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	2.24299
NCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.432
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.505
BRD-K82102352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07191
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.990029
EP300_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09598
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09606
CABIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11033
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	155.925
RNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.244
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10193
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140201
SNRPA1	Pathway Commons Protein-Protein Interactions	1.0	null
U2AF1	Pathway Commons Protein-Protein Interactions	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular transport	GO Biological Process Annotations 2015	1.0	null
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24499
BBS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84468
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.927541
guanethidine-1554	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PFEIFFER	CCLE Cell Line Gene Expression Profiles	1.0	1.49548
BRD-K42716291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82768
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5042_Mut_Adnp_SRP313259	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.4737
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66337
K562_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167809
BRD-K30488928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3727
DNM1L	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAZ	Pathway Commons Protein-Protein Interactions	1.0	null
K562_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172665
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEL	GDSC Cell Line Gene Expression Profiles	1.0	2.27979
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
XRN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K51498205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55701
SRSF4	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-KD-A5QT-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELK1-19687146-Hela cells-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.64005
PMC9661723__F2	PFOCR Pathway Figure Associations 2024	1.0	null
TIA1	Pathway Commons Protein-Protein Interactions	1.0	null
PBX3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28033
CNOT3	Pathway Commons Protein-Protein Interactions	1.0	null
SLCO2B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557937
BRD-A68009927_daunorubicin_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44537081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21037
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160442,GSE160444_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158331
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.66049
BID	Pathway Commons Protein-Protein Interactions	1.0	null
LS-180	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.99527
hsa-miR-4699-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11242342-jcav15p4513s1.pdf-29-ARID5B_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_Myeloid-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3857
TMK-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
NRF1	Pathway Commons Protein-Protein Interactions	1.0	null
SRP72	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92291448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08543
BRD-K57639176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00573
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
MZT2B	Pathway Commons Protein-Protein Interactions	1.0	null
bladder	GTEx Tissue Gene Expression Profiles	1.0	0.982228
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
NR3C1	ENCODE Transcription Factor Targets	1.0	null
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15258
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.141623
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMD13	Pathway Commons Protein-Protein Interactions	1.0	null
Signaling by ROBO receptors	Reactome Pathways 2024	1.0	null
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	1.0	2.09259
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
STAT1-20625510-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.841563
MEL-HO	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.30811
LAN-6	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.22301
abnormality of skeletal morphology	GWASdb SNP-Phenotype Associations	1.0	0.053432
H2BK12ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1568
BRD-K71139459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54798
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mesothelioma_MESO_TCGA-LK-A4O0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCL7C	Pathway Commons Protein-Protein Interactions	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
K562_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218868
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584152
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.69752
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5368
GTEX-X585-0426-SM-4E3JZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24075
SNU466	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73549
Lung adenocarcinoma_LUAD_TCGA-86-7711-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB10	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.99615
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17937
GOS3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.12767
H3K36me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K11795542_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX47	Pathway Commons Protein-Protein Interactions	1.0	null
SART1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44754
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MB-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Plasmodesma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.911
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CQ-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.592
Viral RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.986
GIPC1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_3H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03209
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017615
K562_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160317
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0385
BRD-K07350528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30688
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1428
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.392686
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.165
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.42873
GTEX-QLQW-0726-SM-447AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833618
Ribonucleoprotein granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.404
UACC-257	GDSC Cell Line Gene Expression Profiles	-1.0	-3.00558
MZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.924815
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
EXOSC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHWD-2426-SM-3LK6S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93967
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5463-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
u2-os cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391931
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30013451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0159
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.566
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.657242
GTEX-RTLS-2426-SM-46MUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07627
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-8468-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98355012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03086
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.983133
MIF	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K19755525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09911
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL35A	Pathway Commons Protein-Protein Interactions	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD18	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.23569
testicular cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.256902
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242199_2_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.64091
BRD-K96322674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44577
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.87646
BRD-K85636571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06744
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
hsa-miR-3065-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
olanzapine_rattus norvegicus_gpl1355_gse2547	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF7_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240609
PRPF3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23035
exon-exon junction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.89454
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-92a-3p	MiRTarBase microRNA Targets	1.0	null
GSE158834_11_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRPF4B	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5710-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHF8-20622853-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
XPO5	Pathway Commons Protein-Protein Interactions	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.074416
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.420934
FIS1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906702
K562_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154471
GTEX-POYW-1326-SM-48TCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46897
UBE2N	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL5	Hub Proteins Protein-Protein Interactions	1.0	null
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.8101
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18338
Trametinib_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0273701
EXOSC2	Pathway Commons Protein-Protein Interactions	1.0	null
Supramolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
TRIM21	Pathway Commons Protein-Protein Interactions	1.0	null
CDK9	Pathway Commons Protein-Protein Interactions	1.0	null
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44153
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATM	Pathway Commons Protein-Protein Interactions	1.0	null
NACC1	Pathway Commons Protein-Protein Interactions	1.0	null
TTK	Pathway Commons Protein-Protein Interactions	1.0	null
UCHL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4001
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875355
FUBP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TOPBP1	Pathway Commons Protein-Protein Interactions	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09485
ATP1B3	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
Developmental Biology	Reactome Pathways 2024	1.0	null
POLR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56536
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07431
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063142
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998897
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
rent complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.866287
NCAPD2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.14996
rna catabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70461
CRCGN014_HEPG2_3H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01573
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H5-01B-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Small_Intestine-b cell	Tabula Sapiens Gene-Cell Associations	1.0	0.166756
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2C	ENCODE Transcription Factor Targets	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60938
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.873238
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CD-16-KY17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283823
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8799469-41591_2021_1576_MOESM8_ESM.xlsx-Fig2d_-_PRDM1_57g-SCENIC-predicted_targetome_for_PRDM1_57_genes_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04376
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08335
BRD-K09597785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26168
BRD-K50941255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68014
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37194
BRD-K64822626_KUC104135 KUC104135N_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.76825
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.858
Rectum adenocarcinoma_READ_TCGA-AG-3731-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K27154831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89609
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CKAP5	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166537
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.04851
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191254
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.889984
EIF4G2	Pathway Commons Protein-Protein Interactions	1.0	null
USP35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04259
Mesenchymal cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
RXRB	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7673_KD_UPF2_SRP267245	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
P300-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RACGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
lymph node	HPA Tissue Gene Expression Profiles	1.0	1.42795
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
quantitative	GeneRIF Biological Term Annotations	1.0	null
Neratinib_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0135524
OTUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46241
SMC2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015296
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.63322
exon-exon junction complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_11_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199606_3_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276008
THOC1	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123235
AIMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18631
K562_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176819
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16669
A549_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188671
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0822
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8794
K562_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175982
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06282
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nucleocytoplasmic transport	KEGG Pathways 2026	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_MK-5108_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191335
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39453
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	4.52401
K562_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214306
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FANCD2	Pathway Commons Protein-Protein Interactions	1.0	null
BTK_KO_GDS1346_302_mouse_splenic B cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ERAL1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRRX2	JASPAR Predicted Transcription Factor Targets	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228581
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14318
7067_RAD51B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.603638
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K75224334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34152
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19291
Myotube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.427
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07169
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF676	Pathway Commons Protein-Protein Interactions	1.0	null
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9454
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00317371_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.262
GSE86507,GSE86509_4_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194075
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
cellular macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33413
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877624
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3871
perinuclear region of cytoplasm	GO Cellular Component Annotations 2015	1.0	null
BRD-K04623885_BIBR1532_WSUDLCL2_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FB-56-IR20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200497
Pole plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.307
BRD-A45889380_QUINACRINE HYDROCHLORIDE_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199883
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151393
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57105
binding	GO Molecular Function Annotations 2015	1.0	null
WDR5	Pathway Commons Protein-Protein Interactions	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067107
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25202
JHOS-2	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.77746
GSE100217_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K11757577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80785
telomeric DNA binding	GO Molecular Function Annotations 2023	1.0	null
medial parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.967612
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBE2S	Pathway Commons Protein-Protein Interactions	1.0	null
EIF4E	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
MDST8_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.22555
RFX5	Pathway Commons Protein-Protein Interactions	1.0	null
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16399
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28803
MDN1	Pathway Commons Protein-Protein Interactions	1.0	null
WDR48	Pathway Commons Protein-Protein Interactions	1.0	null
USP48	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192186
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K89116076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04685
Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A36630025_-666_HA1E_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.953973
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IPO5	Pathway Commons Protein-Protein Interactions	1.0	null
MORCPR	CCLE Cell Line Gene CNV Profiles	1.0	1.40703
ANLN	Pathway Commons Protein-Protein Interactions	1.0	null
Gut granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.843
BRD-K18600476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14623
SMN2	Pathway Commons Protein-Protein Interactions	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
P53-22387025-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC3704444__F1	PFOCR Pathway Figure Associations 2024	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38579
Nuclear pore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.657
A549_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243557
EXOSC10	Pathway Commons Protein-Protein Interactions	1.0	null
lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.167764
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
WDR41	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-EP-A2KB-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.45116
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11019654-Supplementary_Data5.xlsx-Sheet1-Table_SV_The_RBP_genes_associated_with_both_NONHSAG037054_2_and_GABPA_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKIV2L2	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-450	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.998903
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74973
Perturb_12953_KO_ZFP36L2_SRP251843	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.54621
Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
SEC23A	Pathway Commons Protein-Protein Interactions	1.0	null
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PKN2	Pathway Commons Protein-Protein Interactions	1.0	null
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF4G1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180275
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.76849
BRD4	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_16891_KO_Lrrk2_SRP308389	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.81788
NCIH524	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36242
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE185519_1_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DCP2	Pathway Commons Protein-Protein Interactions	1.0	null
SCHIP1	Pathway Commons Protein-Protein Interactions	1.0	null
ZC3HC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92433763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.9191
K562_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223873
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156424
JD-87-MR82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338963
Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE7958	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.02369
AURKB	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016562
ZBTB33_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11367
FAHD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02037
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
U1 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.411
A549_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156723
A549_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145271
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227281
Perturb_7218_KD_NOL9_SRP321650	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC7160301-Data_Sheet_1.xlsx-Sup_Table_9-NRF1_interaction_partners_NRF1	Rummagene Transcription Factor Associations 2026	1.0	null
RAE1	Pathway Commons Protein-Protein Interactions	1.0	null
10297_ZNF335_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31629
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91563
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.3773
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
Terfenadine_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244102
lymphoblastoid cell line	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.938439
BRD-K54934070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0029
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154832
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2950-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
A549_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017089
UE-90-AA63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21065
KIF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14255
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMD12	Pathway Commons Protein-Protein Interactions	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.544958
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17352
Mis6-Sim4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.788
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.565631
K562_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0330832
LN18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37912
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPK5-0226-SM-3GAEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824524
mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089961
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCYL1_knockdown_194_GSE57646	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.79131
K562_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268756
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.851041
MHHCALL4	CCLE Cell Line Gene Expression Profiles	1.0	1.83777
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24804
BRD-K13697445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5064
BRD-A95207036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0154
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.11474
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546692
atropine oxide-1370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12431811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67534
PMC11867963-Table1.xlsx-Sheet1-BHLHE40_BHLHE40	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59252
LYL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3351-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Transcription preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.378
Liver Diseases	CTD Gene-Disease Associations	1.0	1.5186
XRN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00946928
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05765
hsa-miR-485-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
BRD-K95148987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35507
OSBPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80169
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.95881
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919314
tm-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.661523
SLBP	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4T8-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16879434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05391
K562_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014999
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60705
BRD-K07691486_roscovitine_MCF7_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYB-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143031
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TE4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43639
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.895688
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
DCP1A	Pathway Commons Protein-Protein Interactions	1.0	null
SFPQ	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852315
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.45574
Delta1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.02
GPS2	Pathway Commons Protein-Protein Interactions	1.0	null
9601_UPF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.537844
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ebolavirus(EBOV)_1day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.198024
GTEX-P4QS-1826-SM-2S1NI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844572
BRD-K81623965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10925
METTL13	Pathway Commons Protein-Protein Interactions	1.0	null
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
CDK2	Pathway Commons Protein-Protein Interactions	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109095
Trifluridine_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0239854
NRG1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141334
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32534
CAOV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46801
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33334
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25467
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27981
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
BTAF1	Pathway Commons Protein-Protein Interactions	1.0	null
lingual gyrus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16999
Mucopolysaccharidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22748970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31027
MCF7_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146126
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06643
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85779
PRPF19	Pathway Commons Protein-Protein Interactions	1.0	null
hela cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.616183
GSE223008_9_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89194869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54704
BRD-A76941896_Doxorubicin hydrochloride_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4424-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44494409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11981
Perturb_7505_OE_ADARB1/ILF3_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.10089
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
VPS33A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE218060_7_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99380757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43983
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K65207153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25422
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.139022
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0909
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6825-01A-21R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABCF3	Pathway Commons Protein-Protein Interactions	1.0	null
COPB2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184356
PRPF6	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0318991
PDLIM7	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205089
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.854
BRD-K70618663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06032
RPL19	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243914
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF768	Pathway Commons Protein-Protein Interactions	1.0	null
GATAD2B	Pathway Commons Protein-Protein Interactions	1.0	null
prostatic neoplasms	GAD Gene-Disease Associations	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10198
Catalytic step 1 spliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.637
ZFP36	Pathway Commons Protein-Protein Interactions	1.0	null
SOX2-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Bosentan (hydrate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0264208
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1993	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mifepristone_homo sapiens_gpl6947_gse39654	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EPS8L2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82324807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53383
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
EPPK1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mdamb134vi	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
COPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36343
GSE223008_5_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63645840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0315
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U4B1-0926-SM-4DXUV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978805
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K09596790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34184
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00573
BRD-A11702965_230752_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25269
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
P-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.43
COPG1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE242199_9_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CDK9_knockdown_71_GSE21751	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.898142
Perturb_7681_KD_UPF2_SRP267245	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
HCC1187	CCLE Cell Line Gene CNV Profiles	1.0	1.67173
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46141
RNA export from nucleus	GO Biological Process Annotations 2023	1.0	null
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.249
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
KNS-81-FD	GDSC Cell Line Gene Expression Profiles	-1.0	-2.00077
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.77301
DNA recombinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
A549_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166192
K562_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151329
SNX22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66609
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.31208
NMCG1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6901
Penis_Foreskin_Fibroblast_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.881229
CAND1	Pathway Commons Protein-Protein Interactions	1.0	null
EE-18-HW72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210297
GTEX-TKQ2-1026-SM-33HB7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26331
binds	GeneRIF Biological Term Annotations	1.0	null
PARN	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11049885__F3	PFOCR Pathway Figure Associations 2024	1.0	null
X-linked dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
TZM-bl cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908406
MED12	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2751_KD_ADAM12_SRP077683	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_24H:B14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00322
Frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.419
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.366623
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78452
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
K562_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176442
A549_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134523
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069076
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279587
Fibrosis	CTD Gene-Disease Associations	1.0	1.08372
cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.285417
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EIF2S1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AC-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ROCK2	Pathway Commons Protein-Protein Interactions	1.0	null
ML264_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.025118
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12523
SAP30	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_24H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50635
ARID1A	Pathway Commons Protein-Protein Interactions	1.0	null
496100641_PCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.10227
A549_Ellagic acid_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157458
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BUB3	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62139
PMC5417597-pone.0176679.s008.xlsx-MLL-TINT_vs_control-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Penis_Foreskin_Melanocyte_Primary_Cells_skin03	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.61111
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ranolazine_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140428
TRIM28	ENCODE Transcription Factor Targets	1.0	null
r74	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
XD-03-FM54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217001
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872616
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MEL-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.83481
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831234
SERF2	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PF-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.246407
GTEX-TSE9-0626-SM-3DB8B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910244
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33156
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.7843
Lenalidomide (hemihydrate)_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0179848
NALM-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17818
GTEX-S7SF-1326-SM-4AD4P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889223
RBM15	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07688551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19179
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.431041
BRD-K96651591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0421
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46557
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdalohippocampal transition zone, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23964
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	3.1988
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.759105
K562_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168009
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14396
glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101258
MCF7_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169643
Upf complex (UPF1, UPF2, UPF3a)	CORUM Protein Complexes	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DFNA5	Pathway Commons Protein-Protein Interactions	1.0	null
JUNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32473
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16426
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PSMD3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.762
SRSF2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K50700697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5292
PMC4470057-12943_2015_398_MOESM7_ESM.xls-probes_KD_inh_in_common-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OMC-1	GDSC Cell Line Gene Expression Profiles	1.0	2.4355
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4059
TNKS1BP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHEK1	Pathway Commons Protein-Protein Interactions	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4669	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-X62O-0826-SM-46MW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868121
HSF2BP	Pathway Commons Protein-Protein Interactions	1.0	null
Rectal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.76
GSE214685_0_v_1_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92632379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56759
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3765
Scd1_DELETION_GDS4910_309_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	1.22404
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49198
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
A549_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014031
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Upf complex (UPF1, UPF2, UPF3b)	CORUM Protein Complexes	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06937
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0919
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.3962
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42004
K562_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170001
smg1	GeneRIF Biological Term Annotations	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32277
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059026
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23670243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51548
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07134
male reproductive organ cancer	GWASdb SNP-Disease Associations	1.0	0.442803
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5711-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_4_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-96-7544-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIP11	Pathway Commons Protein-Protein Interactions	1.0	null
Armadillo-type fold	InterPro Predicted Protein Domain Annotations	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0255858
Acute Myeloid Leukemia_LAML_TCGA-AB-2959-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205963_0_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236534
SEC23B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45817496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66437
Eukaryotic translation initiation factor 2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
SEPT7	Pathway Commons Protein-Protein Interactions	1.0	null
Heart	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K79610347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1932
AP3S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00752
RNA polymerase I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.938
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.0255
sc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7410833-41586_2020_2077_MOESM4_ESM.xlsx-KD-RNA-seq-RBP_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
metolazone-2014	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MHHCALL2	CCLE Cell Line Gene Expression Profiles	1.0	1.63664
SAS	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.71088
A549_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180001
Chromatin silencing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.008
BRD-K13715646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29804
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.37389
GTEX-PW2O-0226-SM-48TC7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14449
A549_Danusertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128058
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.36961
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
interacting	GeneRIF Biological Term Annotations	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41601
outer CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27682
MCF7_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205489
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149824
BRD-K42214389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09461
gene expression	GO Biological Process Annotations 2025	1.0	null
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158768
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32502
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76937233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94409
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JURKAT	CCLE Cell Line Gene Expression Profiles	1.0	1.49251
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IK-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nonsense-Mediated Decay (NMD)	Reactome Pathways 2024	1.0	null
496100357_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09028
A549_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169867
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
motor neuron disease	GWASdb SNP-Disease Associations	1.0	0.792881
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28317
K562_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181005
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.57095
GSE158834_11_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136036
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.0876
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73D-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160077,GSE160084_3_v_0_bin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WEE1_druginhibition_307_GSE38972	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.16584
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF3C4	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
THAP1	ENCODE Transcription Factor Targets	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062383
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871581
GSE146982_3_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91191855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34985
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68602
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43396
CRCGN015_HEPG2_48H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1122
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.93993
prostate	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.890985
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.489
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4777
CRCGN017_MCF10A.TP53.M_24H:E02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9455
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945084
GSE157262,GSE157268_3_v_0_ythdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6970-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
MCF7_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252544
E2F4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189102
hsa-miR-4469	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013766
UACC257	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63479
RB-55-KL42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200609
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4326	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G8-01B-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK3	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228675
WNK1	Pathway Commons Protein-Protein Interactions	1.0	null
upon	GeneRIF Biological Term Annotations	1.0	null
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23664
A549_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161815
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578608
MCF7_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187871
A549_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201609
GSE143643,GSE143644_1_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10627
Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.79769
ERBB2_knockdown_235_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.94642
17616640-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1814
hsa-miR-3142	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
K562_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174589
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02141
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SYK_KD_GDS3609_441_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ZBTB33_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD4	Pathway Commons Protein-Protein Interactions	1.0	null
RAB8B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PARP1	Pathway Commons Protein-Protein Interactions	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052937
Sec62/Sec63 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14396
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32893
STK17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16897
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.21879
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09057
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
THRAP3	Pathway Commons Protein-Protein Interactions	1.0	null
heterocycle catabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17325
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_101_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17567
BRD-K37262603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50074
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32299
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7374-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.30715
MCF7_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140583
C13orf42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13145
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMD1	Pathway Commons Protein-Protein Interactions	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KASUMI-1	GDSC Cell Line Gene Expression Profiles	1.0	2.19224
CAL-51	GDSC Cell Line Gene Expression Profiles	-1.0	-1.62483
BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2756
BRD-K19516614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28893
RCBTB1	Pathway Commons Protein-Protein Interactions	1.0	null
SCAF8	Pathway Commons Protein-Protein Interactions	1.0	null
dexamethasone_mus musculus_gpl6105_gse44208	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal genital system morphology	GWASdb SNP-Phenotype Associations	1.0	0.154907
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151787
High vocal center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.565
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.41115
TUBG1	Pathway Commons Protein-Protein Interactions	1.0	null
LB771-HNC	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48682
GSE223008_0_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACIN1	Pathway Commons Protein-Protein Interactions	1.0	null
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.076
MXI1	ENCODE Transcription Factor Targets	1.0	null
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE110300,GSE110304_0_v_1_estradiol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0418911
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02356
REST_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051381
NCAPH	Pathway Commons Protein-Protein Interactions	1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Valdecoxib_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.02782
H9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.584
K562_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166487
PMC9314667-Table_1.xlsx-Regulons-STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Capivasertib_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0120118
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOP92	CCLE Cell Line Gene CNV Profiles	1.0	1.63665
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28278
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146465
DDX46	Pathway Commons Protein-Protein Interactions	1.0	null
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.898633
A549_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136282
NELFB	Pathway Commons Protein-Protein Interactions	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-NPJ8-1826-SM-2YUNC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23932
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.15841
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855274
BRD-K44212150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10649
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1466
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00781721
PMC3435504-msb201237-s2.xls-Supp_Table_4a-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93564
prostate gland	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.91805
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.081
BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regeneration	GO Biological Process Annotations 2015	1.0	null
RNF130	Pathway Commons Protein-Protein Interactions	1.0	null
YTHDC2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166559
BRD-K84846130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.077
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A0-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
PARVB	Pathway Commons Protein-Protein Interactions	1.0	null
Prion disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
PMC11263707-41419_2024_6896_MOESM4_ESM.pdf-14-TCF7L2_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
HMGA1	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0254
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CSE1L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K66868536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33524
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186631
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EF-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SF3B1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52257
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AQR	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EIF5B	Pathway Commons Protein-Protein Interactions	1.0	null
EP300_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07647
BRD-K74794014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44507
BRD-K13390322_AT-7519_MCF7_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTF3C2	Pathway Commons Protein-Protein Interactions	1.0	null
cancer	GAD High Level Gene-Disease Associations	1.0	0.293278
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MSANTD4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K32947579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24843
BRD-K00950228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20606
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24589
PELP1	Pathway Commons Protein-Protein Interactions	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RELA_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.406
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
mononuclear phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106719
UNC45A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
magnesium-dependent protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.735
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41659
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7287-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8344-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
22RV1_PROSTATE	CCLE Cell Line Proteomics	1.0	3.54429
NDC80	Pathway Commons Protein-Protein Interactions	1.0	null
NCOR1	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11376
GTEX-U3ZN-2626-SM-3DB7T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872837
GTEX-TMMY-0126-SM-4DXTP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999938
MCF7_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176286
CUL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10456
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.45442
PMC5417597-pone.0176679.s006.xlsx-Tumor_MLL_vs_Control-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.961613
bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079137
A549_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118155
CRCGN015_HEPG2_48H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00144
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mode	GeneRIF Biological Term Annotations	1.0	null
GSE121866_1_v_3_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
R2TP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.939
GTEX-OXRO-0326-SM-33HBM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878775
STAB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K51131084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27807
BRD-K68618894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45018
K562_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166583
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.74231
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.471609
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72519
BRD-K08554278_Hoechst  33342 (cell permeable) (BisBenzimide)_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135556
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
18378853-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.74597
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553421
HMGN3	ENCODE Transcription Factor Targets	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFKB2	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207218
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229826
K562_Entacapone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208005
K562_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198384
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060829
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30924
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.497098
DES	Pathway Commons Protein-Protein Interactions	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.950825
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
Nuclear RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.936
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7864-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.37214
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5264-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.77413
nuclear-transcribed mrna catabolic process	GO Biological Process Annotations 2015	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
H2BK5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PLZ5-0326-SM-3P614	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936445
STK24	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0625
MCF7_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017932
CPSF2	Pathway Commons Protein-Protein Interactions	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.29348
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.567
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Fragile X syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32543
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal internal genitalia	GWASdb SNP-Phenotype Associations	1.0	0.207834
Brivudine_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0143504
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039647
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00913
G28T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.914994
K562_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021771
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60705
MAGED2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mrna catabolic process	GO Biological Process Annotations 2015	1.0	null
Bract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K80298486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23859
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87909389_HY-10005_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ARGLU1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4367834-12864_2014_6889_MOESM9_ESM.xlsx-Network_Parkinson_s_Disease-TBP_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
aromatic compound catabolic process	GO Biological Process Annotations 2015	1.0	null
cytoplasmic transport	GO Biological Process Annotations 2015	1.0	null
MCF7_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139398
NANOG-21062744-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49666076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77258
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE51684,GSE51741_2_v_4_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9754
Cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.195
hsa-miR-4700-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.884078
salivarygland_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.941089
Spikelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.898
TEAD4	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
weak	GeneRIF Biological Term Annotations	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WI4N-0726-SM-3TW93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940544
MCF7_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179719
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3YQ-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mist1_22510200_pancreas_c57bl6_lof_mouse_gpl6246_gds4341	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.495191
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136796
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00622
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14318
nucleobase-containing compound catabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COX5B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VUSG-1526-SM-4KKZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14092
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947556
HCC366	CCLE Cell Line Gene CNV Profiles	-1.0	-2.16983
RACK7-27058665-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
rna cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.846532
RELA	ENCODE Transcription Factor Targets	1.0	null
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	1.0	1.24585
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
wm115	HPA Cell Line Gene Expression Profiles	-1.0	-1.18163
SEC24B	Pathway Commons Protein-Protein Interactions	1.0	null
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44542
Daptomycin_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00659554
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIF2C	Pathway Commons Protein-Protein Interactions	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
K562_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155495
K562_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218746
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4R-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1605
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0243
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SEC16A	Pathway Commons Protein-Protein Interactions	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15512
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
LIMK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01646
PDP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72006
SEPSECS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054592
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993167
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04441
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.737
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTBP2	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28206
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.909694
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-AML5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160553
RPL11	Pathway Commons Protein-Protein Interactions	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.996384
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	1.29185
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983553
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460095
PIGF_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Plicamycin_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0158443
Meiotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.057
hsa-miR-3134	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.27997
Cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.195
MAP7D2	Pathway Commons Protein-Protein Interactions	1.0	null
bipartite	GeneRIF Biological Term Annotations	1.0	null
Methylosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.811
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.580086
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SQSTM1	Pathway Commons Protein-Protein Interactions	1.0	null
TIS granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.95
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55218521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71615
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.858884
miR-124_OE_GDS2657_771_human_HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
K562_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172091
prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.285417
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.87173
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09576
translation initiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.779583
FCGR3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514222
Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.94794
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.447259
SENP3	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179996
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841517
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193177_1_v_2_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12954
BRD-K43905345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21865
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NUP37	Pathway Commons Protein-Protein Interactions	1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.1002
BRD-K99690279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37168
Nuclear exosome targeting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.749
Hepatic Cirrhosis_Hepatic Tissue_GSE1843	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.21179
ADAM8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641095
HCC2157	CCLE Cell Line Gene CNV Profiles	1.0	1.80072
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06362
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Spermatid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.511
FAO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
NUP50	Pathway Commons Protein-Protein Interactions	1.0	null
RIOK1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92767663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35227
Transcription export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.538
SP4	ENCODE Transcription Factor Targets	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048211
H2BK120ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7222-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47170544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26228
Translation release factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.269
K562_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178972
MBD3	Pathway Commons Protein-Protein Interactions	1.0	null
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Bisindolylmaleimide IX_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138707
frontal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53489
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01499
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ALDH3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73839
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01713
BRD-K17209411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.35947
GABPA	ENCODE Transcription Factor Targets	1.0	null
CCNT1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.208579
abnormality of the genital system	GWASdb SNP-Phenotype Associations	1.0	0.135908
GSE193177_1_v_3_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNX1	ChEA Transcription Factor Targets	1.0	null
HCC-1599	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.84583
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03547
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904739
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
DDB1	Pathway Commons Protein-Protein Interactions	1.0	null
EXOC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2161
BRD-K99252563_QL-XII-47_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
RPL4	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K79562803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23084
Hailey-Hailey disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.731516
Rectum adenocarcinoma_READ_TCGA-F5-6571-01A-12R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.08599
POGZ	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895126
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.986401
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
Mewo	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.51323
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31225
BRD-K56868780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37442
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.55408
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42335
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41341
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17388
HTC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
MCF7_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014779
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.993741
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33555
Pachytene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.657
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61473
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLEC	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.225969
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928775
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEY1	Pathway Commons Protein-Protein Interactions	1.0	null
EXOC2	Pathway Commons Protein-Protein Interactions	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160373_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
MCF7_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261047
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7229
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4104-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH522	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40098
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EDD_DEPLETION_GDS2445_116_human_embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
K562_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024898
GATAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.103
BRD-K06148621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42149
ATRX	Pathway Commons Protein-Protein Interactions	1.0	null
U20S	BioGPS Cell Line Gene Expression Profiles	1.0	0.953219
AKTIP	Pathway Commons Protein-Protein Interactions	1.0	null
MACF1	Pathway Commons Protein-Protein Interactions	1.0	null
CNN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03771
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
neurological	GAD High Level Gene-Disease Associations	1.0	0.295739
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.054176
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.9556
CD79A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062582
heart	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K77817104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07958
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56381552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77728
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015681
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.930887
BRD-K66030669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00354
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5762
SRF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0452
RAN	Pathway Commons Protein-Protein Interactions	1.0	null
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K52017042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5808
myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.444499
BRD-A25687296_EMETINE_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARL8B	Pathway Commons Protein-Protein Interactions	1.0	null
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.34459
HBZ	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159775
IKBKAP	Pathway Commons Protein-Protein Interactions	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
EXOSC8	Pathway Commons Protein-Protein Interactions	1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01838
PMC10120908-aging-15-204623-s002.xlsx-D-NC1_D-NC2--D1_D2_different_ci-Unnamed_1_DR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
SF3A2	Pathway Commons Protein-Protein Interactions	1.0	null
IK	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21583
BRD-K54742099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46225
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.285417
Vitamin K4_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0123126
HMGB1	Pathway Commons Protein-Protein Interactions	1.0	null
HPB-ALL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38087
Sulfisoxazole_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0379882
EST1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38904629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48403
MCF7_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214234
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05807
FURIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551916
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8123
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LUC7L2	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial cloud	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.68
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.849188
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.894709
ATF2	ENCODE Transcription Factor Targets	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.42072
MYC	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04165
NCI-H716	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862443
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_4945_KO_Rybp/Yaf2/Prc1_SRP247114	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.26515
RS11846	BioGPS Cell Line Gene Expression Profiles	1.0	0.873686
hsa-miR-1275	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K95858622_NCGC00182609-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_5382_KO_Drosha_SRP169088	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.45081
ELK1	ChEA Transcription Factor Targets	1.0	null
A549_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204186
Regulation of expression of SLITs and ROBOs	Reactome Pathways 2024	1.0	null
H2BK120ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09342
communicates	GeneRIF Biological Term Annotations	1.0	null
CDK4_knockdown_85_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.8833
GTEX-XV7Q-0726-SM-4BRV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946115
mRNA cleavage stimulating factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.69
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.05825
bone marrow cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.367129
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170154
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249764
PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194128
A549_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194477
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52707
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60167
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21594
exon-exon junction subcomplex mago-y14	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.784
EP300_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.038493
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
chromosome, telomeric repeat region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.934
ARFGEF2	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186139
697	CCLE Cell Line Gene Expression Profiles	1.0	1.40955
Commitment complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.762
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911187
undergoes	GeneRIF Biological Term Annotations	1.0	null
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
Silodosin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.024833
Hyperplasia	CTD Gene-Disease Associations	1.0	1.59451
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41114
posterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22313
speech-language disorder-1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
BCDIN3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1937
cervical carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.113459
BRD-K35132745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05171
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCR4-NOT core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.18
BRD-A68009927_daunorubicin_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K85907501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41773
HeLa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.205
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.985145
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFE2	ENCODE Transcription Factor Targets	1.0	null
mtor	GeneRIF Biological Term Annotations	1.0	null
CENP-A recruiting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181941
MEC1	CCLE Cell Line Gene Expression Profiles	1.0	1.4957
mRNA surveillance pathway	KEGG Pathways 2026	1.0	null
CAD	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K59517185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08093
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SUMO3	Pathway Commons Protein-Protein Interactions	1.0	null
ARCN1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3607-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GTEX-QLQ7-1926-SM-2S1R6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912471
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063001
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rna	GeneRIF Biological Term Annotations	1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275838
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
HIRA	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.88315
NEURL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00592
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Reactome Pathways 2014	1.0	null
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00259
PMC8394908__F3	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249235
CAL-27	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44809
Axon guidance	Reactome Pathways 2024	1.0	null
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.44768
SU-DHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
16622258-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CTTN	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K35193502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15122
GSE220520_3_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
tonsil	HPA Tissue Gene Expression Profiles	1.0	1.14386
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SGS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.483
BRD-K89476673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93228
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
IPO7	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7399-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hybridoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.421
A549_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192433
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.18452
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851235
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.997536
large	GeneRIF Biological Term Annotations	1.0	null
DOCK5	Pathway Commons Protein-Protein Interactions	1.0	null
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ES6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-58-A46M-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931975
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.637
TPX2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920133
K562_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024494
SEH1L	Pathway Commons Protein-Protein Interactions	1.0	null
IKZF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41727
SMC1A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12434867-NIHMS2107270-supplement-12.xlsx-Table_S4-Table_S4_All_RBP_KO_KD_and_control_samples_information_AR	Rummagene Transcription Factor Associations 2026	1.0	null
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.875199
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.301
cell property	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129511
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336229
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1842
SHROOM3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907179
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.556012
K562_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194851
NCIH1155	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42958
orbital frontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01858
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06398
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44486
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.40666
MCF7_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229452
BRD-K18294143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4025
K029AX	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77401
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21061
K562_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025048
OCI-M1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.20616
P granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.479
IMPDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1174
PMC11009036__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE220520_3_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPL3	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O5-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRSF6	Pathway Commons Protein-Protein Interactions	1.0	null
FBXO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10101
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.875307
cellular_component	GO Cellular Component Annotations 2015	1.0	null
RPS6KB2	Pathway Commons Protein-Protein Interactions	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.982627
MAP1S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11463
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.959157
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24439
H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CARM1	Pathway Commons Protein-Protein Interactions	1.0	null
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
BRD-K08154407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66003
AURKA	Pathway Commons Protein-Protein Interactions	1.0	null
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.223
HEPG2	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.861162
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.924028
MCF7_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149814
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.285417
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05223
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139908
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.929644
NONO	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021881
K562_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156704
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22195
GSE110708_2_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amyotrophic lateral sclerosis	GWASdb SNP-Disease Associations	1.0	0.792881
ECT2	Pathway Commons Protein-Protein Interactions	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
U2-type spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001