association	dataset	threshold value	standardized value
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.99767
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RV-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56196992_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
intermediate stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13966
Seta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.025
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.18047
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.22234
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.579768
UACC62	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.33139
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.890481
heart	GTEx Tissue Gene Expression Profiles	-1.0	-0.824736
nucleic acid binding	GO Molecular Function Annotations 2015	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4505
ASAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.514
DCP2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229716
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49303291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41439
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K05616059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00465
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68694
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0792
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4818-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
External female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.185
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4341
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC56	DepMap CRISPR Gene Dependency	1.0	4.30776
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
PF-00562151-00-5959	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12173
BRD-K36095954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27105
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91777
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.962735
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4912-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163528
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.996374
K562_Toremifene Citrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135592
ioxaglic acid-2966	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A65S-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902515
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373788
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.68
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34639
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RNF38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44955
fulvestrant-5598	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K19011391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28355
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15098674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22254
BRD-K76617730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50778
K562_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0255273
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SJ-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175853
BRD-K21759602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09755
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
K562_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158653
hsa-miR-4314	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4680-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
10073_ZFC3H1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.617018
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAX5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nod2_21335489_hek293_lof_human_gpl570_gds4416	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.001923
decamethonium bromide-4174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prespliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.696
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.579408
hydrocortisone_homo sapiens_gpl570_normal scar_gds3071	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56262
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-0726-SM-3GIJ5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03813
BRD-K06926365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22953
S2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.398
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40242
cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
outer SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.869444
496100614_PCx_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13364
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7877913-elife-59629-supp1.xlsx-CG_SSI2SD_rNSM_0_125-MAR_list_88_out_of_221_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245131
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.899123
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78659596_MLN2238_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.567379
PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843267
GTEX-WYVS-0326-SM-3NM9V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05413
BRD-K45712538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07284
Perturb_2748_KO_STING1_SRP358852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236302
TUBGCP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13746
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K44984558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37381
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.710195
hexestrol-2515	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K40494117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33111
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.948467
CEACAM19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543563
A498	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.84023
BRD-K70052888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25341
quinisocaine-2807	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13966
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
dorsolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00489
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
Inflorescence stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.874
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01682
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QVUS-0011-R9A-SM-3GIJA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04673
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26536
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.615035
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34249
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46997
furazolidone-3358	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.00587
BRD-A42246453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08972
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.19595
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	5.15949
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K07361992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03613
KASUMI6	CCLE Cell Line Gene Expression Profiles	1.0	1.94881
BRD-K64862097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23065
BRD-K16167206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37043
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A69Q-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K83752863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41835
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prestwick-1083-3538	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TP-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nucleotide-binding alpha-beta plait domain	InterPro Predicted Protein Domain Annotations	1.0	null
layer 3 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17782
NCIH1573_LUNG	CCLE Cell Line Proteomics	1.0	3.77343
Acute Myeloid Leukemia_LAML_TCGA-AB-2803-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10165
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64948
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051088
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	2.46683
BRD-K00744507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38186
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1426
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532386
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CREM	ChEA Transcription Factor Targets	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19219
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4332-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.752841
abnormal eye morphology	MGI Mouse Phenotype Associations 2023	1.0	null
PF-00539758-00-6416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KIF21A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0074049
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37316
NAP1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64736
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.08065
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13326
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.850165
AR-A014418-7070	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3495
lateral part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00766
PBDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58879
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10251
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.33949
GSPT1	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87929
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43P-01A-31R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00766
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8971
GSE190761_0_v_1_samd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87340219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18532
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32601
Flocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24496
zona incerta	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.972058
hsa-miR-520b	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
SW626	DepMap CRISPR Gene Dependency	1.0	3.82604
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16647
Cardiac Hypertrophy_Myocardial tissue_GSE5500	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.39959
carcinine-3242	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995842
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.56513
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72919
Posterolateral visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25206
Signaling by ROBO receptors	Reactome Pathways 2024	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78902613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05627
U2 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.52
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05656
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMN-Sm protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.958
hsa-miR-302a	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
rna catabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-300	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.25917
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11718
BD-48-ZT65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251881
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K35588268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22306
BRD-K83690550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49922
NBI-74330	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of the IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58292
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8311-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27554
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
egr1_20019881_retina_lof_mouse_gpl1261_gds3607	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.054247
Prostate adenocarcinoma_PRAD_TCGA-EJ-8474-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Schmid metaphyseal chondrodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.548
GSE182680,GSE182683_0_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64659
GTEX-R55C-0626-SM-2TF4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943003
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K39390441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29972
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.683947
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.829418
Cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17223
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.64847
SKBR3	DepMap CRISPR Gene Dependency	1.0	3.59416
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.48323
Regulator of nonsense-mediated decay, UPF3	InterPro Predicted Protein Domain Annotations	1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.16767
K562_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154325
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.86316
rosiglitazone-6192	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6847-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.171
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.837102
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
E2F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17097
(+)-isoprenaline-3384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98073
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.924804
GSE112995,GSE132079_1_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Upf complex (UPF1, UPF2, UPF3a)	CORUM Protein Complexes	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-519d	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13414
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3QD-01A-32R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ESR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00471079
BRD-K07755570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26339
K562_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231824
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE133516_0_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31799
POU4F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0807
UBR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17279
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04594
thp1	HPA Cell Line Gene Expression Profiles	1.0	1.33972
BRD-K64393896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2965
BRD-A76905089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35609
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-372	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
SMAD3-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34086
MAZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K23800773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18569
GSE126463_4_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH446	CCLE Cell Line Gene Expression Profiles	-1.0	-2.68957
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MINDY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583458
Immune system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.20616
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.84432
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Essential Thrombocytemia_Thrombocyte_GSE2006	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.8634
Developmental Disabilities	HuGE Navigator Gene-Phenotype Associations	1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20393
different	GeneRIF Biological Term Annotations	1.0	null
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.94407
K562_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203677
Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17836
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.92559
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064503
upf	GeneRIF Biological Term Annotations	1.0	null
H4K91ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41662297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08583
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5727
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.690642
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.41492
tightly	GeneRIF Biological Term Annotations	1.0	null
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SARS-dORF6_60Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.78406
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain small vessel disease 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54755
Perturb_9035_KD_FOSL1_SRP320789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.3769
ADGRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31976
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
inner SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.850523
BCOR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.217
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cytoplasmic transport	GO Biological Process Annotations 2015	1.0	null
fat_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.32971
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.972831
hsa-miR-520d-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
MDS - Myelodysplastic syndrome_Bone marrow stem cell_GSE2779	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.11889
SMN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.959
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14887
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83819
CTCF_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-302d	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A48F-01A-11R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.898188
BRD-K73462370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29041
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K19320442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05262
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.4412
SRPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00857113
BRD-K96845170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8666
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09887
K562_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152365
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34155
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0949
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.982683
regulation of translation	GO Biological Process Annotations 2023	1.0	null
BRD-K73451279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22472
BRD-K50367303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09176
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42907
Bract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
pi-body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.051
BRD-K04710685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14385
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.04561
K562_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152574
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05187
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881838
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HU-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metolazone-6292	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NR3C1_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L88	GDSC Cell Line Gene Expression Profiles	1.0	2.45962
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2157	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50403
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.3753
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1943
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68561
K562_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223061
BRD-K94427708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01862
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83336168_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02778
neural stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.516891
intermediate stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0618
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
valinomycin-5906	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.586
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832996
male infertility	IMPC Knockout Mouse Phenotypes	1.0	null
Compound-1a	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73824630_SKATOLE_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46177
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
NCIH2291	CCLE Cell Line Gene Expression Profiles	-1.0	-2.24294
JUND	ENCODE Transcription Factor Targets	1.0	null
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56912
ZC3H7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044988
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
EXOSC4	Pathway Commons Protein-Protein Interactions	1.0	null
COLO668	CCLE Cell Line Gene Expression Profiles	1.0	1.98916
periventricular stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24147
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SRF_SRF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16641781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38744
A549_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010049
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053743
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.406974
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.878163
SIGLEC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00484015
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9071
SNU869	CCLE Cell Line Gene Expression Profiles	-1.0	-3.0544
GSK3B	Pathway Commons Protein-Protein Interactions	1.0	null
biperiden-3321	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K66541877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25324
BRD-K17858048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23393
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-0.879746
SRF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0226-SM-32PLR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84567
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PPP2R5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462677
BRD-K68732617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06283
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.850165
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05345
t30-blood-rna_male_8w	MoTrPAC Rat Endurance Exercise Training	1.0	4.37715
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Embryonic carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.153
HT55	DepMap CRISPR Gene Dependency	1.0	3.23017
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.50807
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hela	HPA Cell Line Gene Expression Profiles	1.0	1.5409
thyroid gland	HPA Tissue Gene Expression Profiles	1.0	1.72487
496100625_FWM_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25194
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12676
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S15-Table_S15_MR_resluts_of_brain_pQTL_and_small-vessel_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65E-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84246050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01488
nuclear-transcribed mRNA catabolic process	GO Biological Process Annotations 2025	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SW-948 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.873
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00858
GTEX-RWSA-0826-SM-2XCBF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9728
GTEX-XUW1-1026-SM-4BONY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922407
BRD-K50924315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4198
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EFM192A	CCLE Cell Line Gene Expression Profiles	1.0	1.51932
upstream	GeneRIF Biological Term Annotations	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8755
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K30910725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1966
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.888306
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.54242
Nuclear RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.003
KDM5B	ChEA Transcription Factor Targets	1.0	null
Cytoplasmic exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.725
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976644
Cyclopamine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.58
BRD-K82922770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10103
PBX3	ENCODE Transcription Factor Targets	1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6191
communicates	GeneRIF Biological Term Annotations	1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.9408
BRD-K71871382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05394
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A06837695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80447
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
HBB	Pathway Commons Protein-Protein Interactions	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00169
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48838
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79473
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sirolimus-921	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251607
EGR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K73296174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01284
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28334
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04472
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCCPDH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520382
Rpd3L complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.865
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42509
496100609_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.84866
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Beta thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SEC31B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20561
BRD-K69942587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08434
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.039
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39375
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05207
nucleus	GO Cellular Component Annotations 2015	1.0	null
KARPAS620	CCLE Cell Line Gene CNV Profiles	1.0	1.5685
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.908129
CYP2A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00481571
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17892
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02915
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05701
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.43177
klf4_17017123_rko_gof_human_gpl96_gds1942	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.250493
RBE	DepMap CRISPR Gene Dependency	1.0	2.18362
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5645
Bed nuclei of the stria terminalis, anterior division, magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28725
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.13654
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-87-EI21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276832
GSE152432_9_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03577
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994594
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z4-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BL7558 (UPF1)	NURSA Protein Complexes	1.0	null
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.642396
PHF8	ENCODE Transcription Factor Targets	1.0	null
Infralimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28725
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.926941
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26902
DHODH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555155
ZEB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07727
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7964
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170393
GSE255432_4_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29841
RNA polymerase I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.904
primary auditory cortex (core)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.83955
GSE60217_1_v_9_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-0.954116
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55956
SMG5	Pathway Commons Protein-Protein Interactions	1.0	null
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.568051
CTCF-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
DAPP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554369
embryonic lethality between implantation and somite formation	MGI Mouse Phenotype Associations 2023	1.0	null
ITGB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504101
Embryonic tracheal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.53969
posttranscriptional	GeneRIF Biological Term Annotations	1.0	null
pre-snoRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.099
A549_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189025
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100634_HIP_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.76309
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207991
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
Large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.501
7509_RPS19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.652905
Height	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of translation	GO Biological Process Annotations 2025	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.642568
K562_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233856
complexes	GeneRIF Biological Term Annotations	1.0	null
UPF1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155095
K562_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015801
GTEX-WK11-0926-SM-3NMAU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25621
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_SW948_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMAD4	ChEA Transcription Factor Targets	1.0	null
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CASC3	Pathway Commons Protein-Protein Interactions	1.0	null
MAGOH	Pathway Commons Protein-Protein Interactions	1.0	null
BTN1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00465807
Crus 2, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39769
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24119
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23233
RAPH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00804586
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52406
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cefixime-3247	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K72146456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0888
BRD-A59683007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57928
BRD-K80198069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52582
DNA polymerase III, clamp loader complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.627
Hailey-Hailey disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMG1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K38046923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82117
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964699
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843827
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.503917
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212053
Pamidronic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79232672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44054
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0658
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.886885
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08076
BRD-K62909525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14522
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843541
GATA3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IFITM2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1836	CCLE Cell Line Gene Expression Profiles	1.0	2.25185
RAD23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43248
BRD-K35133923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35734
KALS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCIH1963	CCLE Cell Line Gene Expression Profiles	1.0	2.67393
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48667
HCC1806	CCLE Cell Line Gene Expression Profiles	1.0	1.53813
induseum griseum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57583
Fetal Death	CTD Gene-Disease Associations	1.0	1.10527
K562_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0271538
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78793
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K66605600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15061
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.87188
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44953
alfuzosin-5605	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SW1463	GDSC Cell Line Gene Expression Profiles	1.0	1.82878
REST_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small testis	MGI Mouse Phenotype Associations 2023	1.0	null
seminal vesicle	HPA Tissue Protein Expression Profiles	-1.0	-1.31276
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75730049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49628
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB33_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LCP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574461
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.969334
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r4 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43902
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870745
CDR2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601636
hsa-miR-145	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4971-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9547
BRD-K70511574_sunitinib_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dcp1-Dcp2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.953
EP300	ENCODE Transcription Factor Targets	1.0	null
GSE178714_3_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.33848
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35021
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
NIBAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6488
NFATC1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4637	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
ERBB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00398317
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9294
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11776
BRD-K38424085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07382
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82519
HSF1_KD_GDS1733_751_human_HeLa cells - 0.5 Hour by siHSF1_1	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K83012560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36699
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.980109
BRD-K49443464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70998
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90961
Companion cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21981
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F1-26619117-HEPATOCYTES-MOUSE-LIVER	ChEA Transcription Factor Targets 2022	1.0	null
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
BRAF_druginhibition_175_GSE42872	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.94777
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87688
DBTRG05MG	CCLE Cell Line Gene CNV Profiles	1.0	1.33579
FOXM1	ENCODE Transcription Factor Targets	1.0	null
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE155031_6_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bed nuclei of the stria terminalis, anterior division, ventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01252
VAChT_KD_GDS4325_361_mouse_Heart from C57BL/6 males	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K76401790_JNK-IN-5A_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r2BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07107
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14991
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.063492
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28373
BRD-K37601439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07967
BRD-K62965224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82465
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6845
exonjunction	GeneRIF Biological Term Annotations	1.0	null
positive regulation of protein metabolic process	GO Biological Process Annotations 2023	1.0	null
CAOV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2843
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
nilutamide-3104	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34842
BRD-K40985311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03912
CREB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18767
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344543
betazole-5445	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23860926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23192
dimenhydrinate-6352	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMS12BM	CCLE Cell Line Gene Expression Profiles	1.0	2.02526
BRD-K12340493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06124
BRD-K82102697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21116
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37197
K562_Navitoclax_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167002
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4924
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831809
Sensillum trichodeum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.023
BRD-K76401790_JNK-IN-5A_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nuclear transport	GO Biological Process Annotations 2015	1.0	null
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00208
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4082
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.993274
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857049
NCIH2291_LUNG	CCLE Cell Line Proteomics	1.0	2.92256
BRD-K28932860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31713
layer 2 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19474
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256058
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38818
BRD-K93126086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76063
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.002
PANC1	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.831537
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.14126
K562_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136649
POLR3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.056
NCI-H2291	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50953
PML	ENCODE Transcription Factor Targets	1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MF-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Postsplicing complex	CORUM Protein Complexes	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDK8_knockdown_129_GSE30816	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.6057
ZBTB16-27035670-HESC-HUMAN-ENDOMETRIAL	ChEA Transcription Factor Targets 2022	1.0	null
GSE128076_2_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-1537	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-13q34_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MEK_INHIBITION_GDS5029_278_human_SW480 KRAS-mutant colorectal cancer cell line - 4hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471149
posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05856
NCIH1648	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64588
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38828
H3K36me3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0526-SM-2TF4N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03495
BRD-K34664417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81419
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19203
BRD-K04108962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42327
PPP2R3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00709987
induce	GeneRIF Biological Term Annotations	1.0	null
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16444
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.56108
mantle zone of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18905
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2002
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A51B-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10124
BRD-K41382866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88405
SNUC1	DepMap CRISPR Gene Dependency	1.0	2.23466
PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Gene_Name_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XV7Q-0005-SM-4BRWI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03366
H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42113
non-syndromic intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.485
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
Pollen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.158
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	2.18962
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57196
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
UPF2	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03451
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07891
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
EIF4G1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659474
K562_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171023
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.82416
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNMT1	MSigDB Cancer Gene Co-expression Modules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26821
BRD-K74522958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33219
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70889
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40294
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NM-01A-21R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16401
superficial stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17223
MAP2K7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00377878
triflusal-2867	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991294
dirithromycin-2863	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
moracizine-6000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
sequence-specific DNA binding	GO Molecular Function Annotations 2025	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16973
ELF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160061
glafenine-7418	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37771
0317956-0000-3966	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ursolic acid-2067	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K39476596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55835
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.939892
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A856-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72989
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.04279
Lung squamous cell carcinoma_LUSC_TCGA-85-A4PA-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44833
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951775
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9023
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12197
CHEMBL2431803	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
PACADD161	DepMap CRISPR Gene Dependency	1.0	2.09435
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.17
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07215
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A299-01A-21R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HJ-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82681356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6396
K562_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141085
K562_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0308463
EIF2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59208
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460753
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.685279
CTCF_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clofilium tosylate-6830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
STAT3_deficiency_GDS3106_58_mouse_type II alveolar cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43173
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87688
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A3KF-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21847
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891146
EIF4A3	Pathway Commons Protein-Protein Interactions	1.0	null
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
temporal pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00623
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.501
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
BRD-K47983010_BX-795_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
promethazine-6477	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89857
Spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.088
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.26492
BRD-K28848179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80129
renal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.67658
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHEMBL1643306	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GSE60217_1_v_7_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.15138
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43902
translation	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q2AH-0726-SM-2I3EA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858197
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21592
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMBC2	DepMap CRISPR Gene Dependency	1.0	3.24588
GSE220520_3_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934778
BRD-K81608755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10903
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Venom gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
chlorcyclizine-3893	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64227
nmd	GeneRIF Biological Term Annotations	1.0	null
VPS4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00400158
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79414
BRD-K64353626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.5849
BRD-K44265418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63978
FOXA1_01_105	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59049
CAMA1	DepMap CRISPR Gene Dependency	1.0	2.95697
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7935
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336803
hippocampus (hippocampal formation)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.825081
HSC5	DepMap CRISPR Gene Dependency	1.0	2.46768
BRD-A89038047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08455
A549_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139735
KMH2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39312
RAD21_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.64677
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
ESPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00622
BRD-K58168959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62648
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.853358
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975323
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852041
Floret	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
BRD-K54478142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44939
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32171
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85592
Gene Expression	Reactome Pathways 2014	1.0	null
BRD-K38946705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76022
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.860758
Pulse pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.9
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051488
SMG7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869409
Teratocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
r10 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06676
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08646
BRD-K32251128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30149
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.938703
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913003
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
containing	GeneRIF Biological Term Annotations	1.0	null
outer SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27071
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.763685
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241812
Lsm2-8 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.794
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Eukaryotic translation initiation factor 3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.072
Ventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16673
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16357
BRD-K73831263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39651
Lung adenocarcinoma_LUAD_TCGA-MN-A4N4-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01774
nuclear-transcribed mRNA catabolic process	GO Biological Process Annotations 2023	1.0	null
KM-H2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.98672
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881378
BRD-K61681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88254
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.02077
BRD-A47513740_calyculin A_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7416-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A99990159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01563
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39906
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57979
r4 part of medial paralemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03255
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAB32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65193
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.649
nucleoplasm	GO Cellular Component Annotations 2015	1.0	null
BRD-K55187425_ON-01910_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
K562_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160169
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tyloxapol-6452	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sin3-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.819
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17717
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23429
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.879259
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76133
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.843108
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58127
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
alpha-yohimbine-6274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86774687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71091
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
18362358-Table7	GeneSigDB Published Gene Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-A59Q-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382239
mRNA binding	GO Molecular Function Annotations 2025	1.0	null
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.501729
496100619_HIP_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12429
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.16034
PDGFD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059114
GSE114685_1_v_0_grin2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A73150064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16209
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.30564
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bipolar Disorder_Cerebral cortex_GSE12649	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.5259
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825148
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2181
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.87524
BRD-K54233340_Dorsomorphin dihydrochloride_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K18178356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03249
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Lung squamous cell carcinoma_LUSC_TCGA-56-A4ZK-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151937
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.25545
BRD-K78612514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55161
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.73187
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902515
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.69245
H3K36me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAPK1_knockdown_131_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.39555
BRD-K11545984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56248
CTCF	ChEA Transcription Factor Targets	1.0	null
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951437
MCF7_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132886
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic substance transport	GO Biological Process Annotations 2015	1.0	null
TEAD4	ChEA Transcription Factor Targets	1.0	null
OMC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.32538
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46424
Lateral reticular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17223
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.49326
guanethidine-5731	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K16730910_regorafenib_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SUCS-0226-SM-32PLQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962732
MYC-19915707-AK7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151464
BRD-K44643967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49647
H3K36me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.47594
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31753
K562_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023532
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.266413
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.58448
PCBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17849
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.47616
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30625175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14447
CEBPD	ENCODE Transcription Factor Targets	1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946198
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.516631
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48792
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.648959
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65441343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06269
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35834
Breast_Myoepithelial_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.912744
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3171
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6278
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63892351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16211
Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K08867654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6908
Congenital muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48527
ribavirin-7316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191111
BRD-K77940693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10312
PMC8082775__F3	PFOCR Pathway Figure Associations 2024	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
SCN9A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00594832
CHD1	ENCODE Transcription Factor Targets	1.0	null
genistein-6952	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93391478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35887
hsa-miR-106a	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.181
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528872
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0726-SM-2XCD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925156
BRD-K18070214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26844
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51488
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95657
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.653298
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31722
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33379087_tivantinib_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67670670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62256
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.837466
BMPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642388
cellular nitrogen compound catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-A04231641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98489
(-)-isoprenaline-3571	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K16512302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22515
NR2F2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75456
hsa-miR-4420	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
periventricular stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23481
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494512
A549_Flavopiridol HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014112
PHA-00816795-7076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of the IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57583
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE194396,GSE194429_2_v_3_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUZC-0126-SM-4BOO6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894299
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.72848
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08879
Brain Lower Grade Glioma_LGG_TCGA-VV-A86M-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skin	HPA Tissue Gene Expression Profiles	1.0	1.05189
TET1-21451524-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.933658
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00079
Liver bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.852
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23562
XRN1	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05357297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83281
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
RPS6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583195
tribenoside-2946	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
cortex of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04218
Ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.903
BRD-A53850583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47115
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.346
hsa-miR-3155b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61296
HCC2157	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54875
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46051
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.962
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178340_7_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.546
regulation of translation	GO Biological Process Annotations 2015	1.0	null
PMC11184788-40164_2024_526_MOESM4_ESM.xls-MSC-EV_proteins-Unnamed_4_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537398
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.772
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29321
BRD-K91998226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25255
posteroventral (inferior) parietal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.964125
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16518
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.301414
Perturb_2698_KD_EXOSC8_ERP005739	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
YKG-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PORCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02534
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10822
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73192
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.27978
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373251
ACTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556032
PFKM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00416878
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r9 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76994
BRD-K40509138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03735
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2901
SF539	DepMap CRISPR Gene Dependency	1.0	2.57416
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.06345
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.31276
BRD-K56645451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2011
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216712
septopallidal shell area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09262
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68174511_torin-2_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.7103
mRNA cleavage and polyadenylation specificity factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11757
Necrosis	CTD Gene-Disease Associations	1.0	1.7544
nimesulide-2112	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919946
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178694
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22338979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47043
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.38805
K562_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178308
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1225
SKES1_BONE	CCLE Cell Line Proteomics	1.0	2.56516
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.913306
PKP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49678
Pachytene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
acetylsalicylic acid-1204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178340_5_v_9_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r9 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09262
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56153
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207767
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cambium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
superficial stratum of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04379
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842959
Prostate adenocarcinoma_PRAD_TCGA-EJ-8469-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cytosolic small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.804
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8Q9-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203-2004(H5N1)_2day-TNFRSF1BKO_None_GSE40792	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.05416
DKMG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55629
BRD-K61441533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50073
4108_IMP4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.597164
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r8 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2993
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895072
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08027
mdamb134vi	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7823-01B-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0482
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
PMC4063835-epi-9-760-s02.xls-MI_vs_NU-SYMBOL_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
FLI1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FZD10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00655565
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
NCIH889	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76205
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Methylosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.126
SMAD4-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4438	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_10_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49335
GTEX-WVLH-0626-SM-3MJG7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1426
Perturb_16610_KO_Phb_SRP229743	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48527
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
TYK2_knockdown_176_GSE44652	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.13335
efo21	HPA Cell Line Gene Expression Profiles	-1.0	-1.8228
inferior frontal gyrus, orbital part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12054
atypical autism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.55867
Ski complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.326
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.95938
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.41112
Exoribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.883
GSE99187_1_v_0_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15896
BRD-K58865204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1606
A549_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107202
GSE156667_0_v_1_lrrc8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C75	DepMap CRISPR Gene Dependency	1.0	4.82083
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.15642
foliosidine-2201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.20982
BRD-K01827055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92222
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80692
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7915
HMGB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10632
BRD-K63107801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41511
SARS-CoV_72Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.71133
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.879739
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.966374
P31FUJ	CCLE Cell Line Gene CNV Profiles	1.0	2.25253
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05653
sequence-specific DNA binding	GO Molecular Function Annotations 2023	1.0	null
positive regulation of protein metabolic process	GO Biological Process Annotations 2025	1.0	null
LD-48-CY61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314318
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52224
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48562
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09887
H3K36me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0EZ-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.992048
methylbenzethonium chloride-2190	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12284
HMGA1_02_75	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58943
H3K56ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FBXO41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3187
5657_NFYB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.668535
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.86082
ABC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76088
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.79247
hl60	HPA Cell Line Gene Expression Profiles	1.0	1.04016
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.03473
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Table_S1_Lists_of_translational_targets_of_MYC_in_MYC_ON_vs_MYC_OFF_P493_cells_and_their_5_UTR_sequences_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.586276
brain	GTEx Tissue Gene Expression Profiles	1.0	0.96842
IDRA-21	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23605
15843827-TableS11	GeneSigDB Published Gene Signatures	1.0	null
SCOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32494
chr13_114235175_G_T_b38	GTEx eQTL 2025	1.0	1.84642
BRD-K79090631_CGP-60474_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K75857911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10373
GSE226249_0_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467811
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	3.63799
GATA5_KO_GSE47425_386_mouse_lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
LRCH4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504445
enalapril-2397	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5GH-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164661
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z2-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15893
meclofenamic acid-7038	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
icSARS CoV_72Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.82587
KRTAP5-8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00451411
CRIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056836
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207975
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864457
Nuclear cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.082
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-toNode_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40061713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90401
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.46472
BRD-K22608982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.13797
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pretectal region	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.992787
cellular macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
synapse-associated extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.871
NCI-H2066	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K33217094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61494
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245884
PARN	Pathway Commons Protein-Protein Interactions	1.0	null
496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32574
H4K20me1_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16874
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	4.71441
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885887
PIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00804341
BRD-A05823365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40611
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.899254
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.88109
GSE60217_1_v_10_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r9 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47152
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.1195
Sm-like protein family complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.723
H3K36me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hMPV_24Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.44996
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	2.92655
NCIH2122	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47028
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PROC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571194
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8430-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
serotonin-5633	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K41707029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82923
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.86204
NCIH1694	DepMap CRISPR Gene Dependency	1.0	3.32315
Immune system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26348
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92695
BRD-K15827385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17496
acetylsalicylic acid-5201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-142-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Rectum adenocarcinoma_READ_TCGA-F5-6863-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45022385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24565
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4223
BRD-K45062933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07784
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249862
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.45797
Viral assembly intermediate	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.906
GTF3C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12839
GTEX-QMRM-0726-SM-2I5G8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881533
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343451
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0326-SM-3DB86	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03865
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.05887
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.902448
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.891284
BRD-K62309465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33426
alpha-estradiol-1210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KU812	CCLE Cell Line Gene CNV Profiles	1.0	1.67862
CHD2	ENCODE Transcription Factor Targets	1.0	null
CMKLR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00500248
ECC12	CCLE Cell Line Gene Expression Profiles	1.0	1.8276
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE1551	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.6455
CD84	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00845432
intermediate stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2993
r9 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42501
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11951
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Schizozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA46	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43852
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423077
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GMP reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
MAPKAPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00350215
basolateral nucleus (basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.997368
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161687
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VMRCRCW	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76989
NAMALWA	CCLE Cell Line Gene Expression Profiles	1.0	1.52648
INSIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95879
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43269
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Reactome Pathways 2014	1.0	null
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277847
GSE133927_1_v_3_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06676
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DNAPK	Kinase Library Serine Threonine Kinome Atlas	1.0	null
mefenamic acid-5534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-7023-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCOR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00748028
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21847
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80Q-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GR-ST	GDSC Cell Line Gene Expression Profiles	1.0	1.61547
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.81157
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5285
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.025
hsa-miR-20b	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	1.64218
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molecular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27377
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051815
Scrapie	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
r3 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24147
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.93941
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829558
Nodular Sclerosis Classical Hodgkin Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
AKR1C3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00404987
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal eye morphology	IMPC Knockout Mouse Phenotypes	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8171-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHCHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97439
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JHUEM1	DepMap CRISPR Gene Dependency	1.0	3.10768
K562_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178342
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alsterpaullone-7078	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARS-dORF6_72Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.54218
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-PN-A8MA-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953157
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05317
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BF-00-PE90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348283
SLC35C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516487
CEBPE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637212
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.16515
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54256913_MK-1775_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r9 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46481
BRD-K39396484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14615
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
heterocycle catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE112761,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Spliceosomal snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.671
BIN67	DepMap CRISPR Gene Dependency	1.0	2.04184
K562_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163665
hsa-miR-323b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GTEX-WH7G-0526-SM-3NMBI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916728
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE233256_0_v_1_rbms1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29198
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44619
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.975
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52958
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.64452
GTEX-WFJO-0226-SM-3GIKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909733
GSTM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571694
BRD-K28728910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02959
hMPV_48Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.18524
GTEX-PLZ4-1226-SM-2I5FE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945862
BRD-K75900642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63502
KLE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50893
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
protoveratrine A-2800	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K91923964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11578
BRD-K87433679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20588
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8511
dioxybenzone-6478	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
mrna metabolic process	GO Biological Process Annotations 2015	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39099034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20654
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
SARS-dORF6_84Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.85573
Prion disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
K562_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240534
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200846
ERBB2_knockdown_233_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.65329
K562_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162969
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63299069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44788
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0203
ZBTB33_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4520b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
COLO-668	GDSC Cell Line Gene Expression Profiles	1.0	1.87382
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0431
bronchus	HPA Tissue Protein Expression Profiles	1.0	2.18962
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.905123
BRD-K40776502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69008
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
methyldopa-5637	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531857
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.09114
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.13643
Spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.541
BRD-K30312557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17268
K562_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139639
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HuO9	GDSC Cell Line Gene Expression Profiles	1.0	1.60309
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39961819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53601
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03654
GTEX-TKQ1-0126-SM-33HB3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881813
BRD-K11342801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66916
TET1	ChEA Transcription Factor Targets	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2716-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75380271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03682
ZNF443	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73801
superficial stratum of PSPa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.108
nucleic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04765
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85149
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16955
UPF3B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
r10 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11874
BRD-K13679727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29446
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
BRD-K74971765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54686
JM1	CCLE Cell Line Gene Expression Profiles	1.0	2.00136
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.90585
positive regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3155	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
sulfachlorpyridazine-3769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
erastin-6369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NR3C1	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36368
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
BRD-K27109474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15606
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06401
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414137
8738_TBL3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.578248
POLR2AphosphoS5_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13646706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20055
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TQ-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38388
GSE190186,GSE190188_8_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nuclear lumen	GO Cellular Component Annotations 2025	1.0	null
CYP2B6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529263
BRD-K60456515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10628
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HPAF-II	GDSC Cell Line Gene Expression Profiles	-1.0	-2.16477
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A564-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43000271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1002
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047972
RGS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584522
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-0726-SM-4BRWY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935028
BRD-K22534934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08102
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
salivary gland	HPA Tissue Protein Expression Profiles	-1.0	-1.31276
BRD-K11730256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18923
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.96743
EFM192A	CCLE Cell Line Gene CNV Profiles	1.0	1.89576
BRD-K17122222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79582
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6431
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ventral posterolateral nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00386
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.994451
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.56907
BRD-K39237487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95403
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.6403
GNB1	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09239
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mrna catabolic process	GO Biological Process Annotations 2015	1.0	null
9687_UTP6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.593882
inner SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51517
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.8397
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleolus	GO Cellular Component Annotations 2023	1.0	null
magnesium-dependent protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.651
hsa-miR-1267	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863725
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.90625
r2 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06943
K562_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190938
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06643
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16957
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53108
BRD-A80057650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10261
COLO668	CCLE Cell Line Gene CNV Profiles	1.0	1.69686
acronycine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84631
Lung adenocarcinoma_LUAD_TCGA-78-7155-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
rotenone-5943	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleobase-containing compound transport	GO Biological Process Annotations 2015	1.0	null
JEG3	DepMap CRISPR Gene Dependency	1.0	5.97103
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5066-02A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7643
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Retrosplenial area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.33194
PIGT	Pathway Commons Protein-Protein Interactions	1.0	null
ED-32-VE54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.462844
TFE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55261
DMBT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595378
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
BRD-A63382799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73279
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
finasteride-6062	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82823857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03768
GSE201217_2_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01259
BRD-K85500722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49843
BRD-K59317601_INK-128_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A96183603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37094
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06772
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877648
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
17963910-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3631
BRD-K14920963_ERYTHROSINE SODIUM_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
aminohippuric acid-6453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.65551
PSMA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540753
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.878789
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7523
GTEX-T2IS-0626-SM-32QP6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18965
PMC4944136-srep28995-s2.xls-OTX2-gene_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44092
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11874
SELPLG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00532088
SW982	DepMap CRISPR Gene Dependency	1.0	3.01116
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.00606
BRD-K66016089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04913
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12147
SUDHL8	DepMap CRISPR Gene Dependency	1.0	4.61256
BRD-A44068497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34876
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Nrd1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.777
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08802
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900367
7499_RPS11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.679408
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50210179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83526
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0562
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87688
BRD-K78403457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42927
MCHR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66866
4682_LRSAM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511057
membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K79090631_CGP-60474_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175776
EVSA-T	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47778
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207909
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rna transport	GO Biological Process Annotations 2015	1.0	null
decitabine-920	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PABPC4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21585
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
HTT	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.94328
digoxigenin-3397	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
positive regulation of cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CFPAC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.67199
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835569
hsa-miR-4742-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
OVCAR5	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.08997
ZBTB33_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64531
DEAF1	MSigDB Cancer Gene Co-expression Modules	1.0	null
hsa-miR-522	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
HLA-DRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00529184
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950183
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46684
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12048
hsa-miR-24	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23021
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CAF-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.526
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.70401
regulation of cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PMC3189923-pone.0025991.s001.xlsx-CENPT-Unnamed_1_CENPT	Rummagene Transcription Factor Associations 2026	1.0	null
P4HB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061102
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TRIFLUPERIDOL-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29764
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68103
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44047
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rolapitant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
K562_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187791
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04958
Prostate adenocarcinoma_PRAD_TCGA-VN-A88M-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256934
nucleocytoplasmic transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34391
estradiol-5960	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMPRSS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613533
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	1.0	0.969907
procaine-1796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.963307
r10 part of vagal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00266
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67646
GSE229978_4_v_2_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
r1 part of vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3105
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172628
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6968-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
shell of SCH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33895
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ethynyl Estradiol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.59
gene expression	GO Biological Process Annotations 2015	1.0	null
BRD-K56653679_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
HLE	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43202
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0226-SM-3DB7B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02962
RORC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561149
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.489
Nuclear RNA export factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.191
WHSC1	ENCODE Transcription Factor Targets	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
EFO-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.855905
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017544
E2F6	ENCODE Transcription Factor Targets	1.0	null
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31131
DEDD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67255
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2919-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lateral root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.829
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144741
HPAFII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87578
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A31962514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08894
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6825
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.908129
K562_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189146
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01682
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6894
mRNA binding	GO Molecular Function Annotations 2023	1.0	null
autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.900746
neurological	GAD High Level Gene-Disease Associations	1.0	0.293278
Acute Myeloid Leukemia_LAML_TCGA-AB-2903-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
METTL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25903
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A40010674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67412
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.989846
RPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63525
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.892931
Skeletal Muscle Female	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.2451
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.86505
LB647-SCLC	COSMIC Cell Line Gene CNV Profiles	1.0	2.15316
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09624
ventral entopeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10642
cellular_component	GO Cellular Component Annotations 2015	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
NDR2	Kinase Library Serine Threonine Kinome Atlas	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7125
trichostatin A-7136	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
RUNX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555716
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.671345
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
basomedial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.89284
BRD-K16852474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55789
K562_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149319
BRD-K78262424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43352
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nafamostat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96635
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36368
GTEX-R55C-1926-SM-2TF4K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859629
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kb NB 142-70	DeepCoverMOA Drug Mechanisms of Action	1.0	1.1
A549_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138073
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27199
PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Ensembl_Gene_ID_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.2795
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K93176491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42627
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMT2A	MSigDB Cancer Gene Co-expression Modules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44619
THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.259
Nucleus of the lateral olfactory tract, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09784
OCI-LY-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16656
ELK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005384
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO205	DepMap CRISPR Gene Dependency	1.0	4.83959
BRD-K48611791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42926
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5895607-41388_2017_42_MOESM4_ESM.xls-geneNames-Extended_Data_3_Gene_list_of_SRC-1_targets_which_contain_STAT1_binding_motifs_from_LY2_cell_RNAseq_data_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K78939372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37275
CBX3	ENCODE Transcription Factor Targets	1.0	null
PXDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25653
LC1SQSF	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3338
prazosin-6475	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K43388152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0932
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
hydroxyachillin-2157	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EP300_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897911
spliced	GeneRIF Biological Term Annotations	1.0	null
BRD-A31602150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19526
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r10 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00766
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50109
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68F-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPAS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33723
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FG syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993104
hsa-miR-302e	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31332
ICC8	DepMap CRISPR Gene Dependency	1.0	5.86563
BRD-K87472370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07913
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.57883
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68588
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25013
PITX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10142
BRD-K85294251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70472
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07528
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127135
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33379087_tivantinib_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K58498516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41238
Chromatoid body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.609
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1472
BRD-K86232198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19828
intermediate stratum of r10BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01252
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH446	CCLE Cell Line Gene CNV Profiles	-1.0	-2.01735
SR 3335	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.42
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fragile X syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
SMAD3	ChEA Transcription Factor Targets	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.43018
finasteride-2206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55672
BRD-K67426191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01929
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Unnamed_1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.60296
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K58534227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03022
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28613
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
CTCF-21964334-BJAB-B-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A361	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.10999
High vocal center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A954-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14702616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24996
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80982
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	3.87365
Regulation of expression of SLITs and ROBOs	Reactome Pathways 2024	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.825028
BRD-K53617314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50488
SPI1	ENCODE Transcription Factor Targets	1.0	null
Entinostat	DeepCoverMOA Drug Mechanisms of Action	1.0	1.52
GATA1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UACC62	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25288
Spinal Cord Injury_CNS - Spinal Cord (MMHCC)_GSE16710	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.62735
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.025
A3KAW	CCLE Cell Line Gene Expression Profiles	1.0	1.35688
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
r7 part of the basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13966
SIRT6	ENCODE Transcription Factor Targets	1.0	null
HNRNPA1	Hub Proteins Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
FREY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06877
Nodular sclerosis Hodgkin lymphoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.730103
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1648	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66992
RASGRP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595146
BRD-K81181894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28158
NCOR1	ENCODE Transcription Factor Targets	1.0	null
BRD-A14803952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64004
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.29379
NDUFA13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055553
BRD-K68618340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1534
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LU-65	GDSC Cell Line Gene Expression Profiles	1.0	1.51128
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.927807
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.82
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74632893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12582
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.92471
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.888306
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5689-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
basal nucleus of Meynert	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.853626
BRD-K68312794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70535
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K51167279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36706
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12928
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-17	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05743
BRD-K59856141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95114
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50569
switch	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75423
Delta1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.943
BRD-K88080911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78442
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95114
BRD-K97081185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62306
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.29448
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87637
outer SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.893407
nucleobase-containing compound catabolic process	GO Biological Process Annotations 2015	1.0	null
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390075
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.873059
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.877864
outer SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5323
HeLa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.025
BRD-K22748970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01795
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37217
Thalassemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
OE33_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.92256
Purkinje cell layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19149
BRD-K34264024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36352
GTEX-T6MO-0226-SM-32QOL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939138
Activating signal cointegrator 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.961
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842959
BRD-K68980973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10181
BRD-A50701104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05407
cellular process	GO Biological Process Annotations 2015	1.0	null
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58797
CACNA1H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00906553
BRD-K30326216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80679
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.888084
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.25062
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.79684
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.42081
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95359959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38074
CCR4-NOT core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25384
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.571767
BRD-K73789395_ZM 336372_SKLU1_6.0_h_102.71_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057533
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.878131
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24417
KMRC-20	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33142
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189285
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26388
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51997
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07025
BRD-K21864149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15027
E2F4-21247883-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-0926-SM-4JBHQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16164
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86105
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.640097
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37764012_PF-3758309_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K63864310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3902
BRD-K71563254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19254
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257693
hsa-miR-2115	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10362
BRD-K95788660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94913
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleocytoplasmic transport	KEGG Pathways 2026	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.309
GTEX-V955-0426-SM-3GAEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916479
Lung squamous cell carcinoma_LUSC_TCGA-60-2704-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A62995832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03495
BRD-K54100199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16006
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rna binding	GO Molecular Function Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A5C7-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193573
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13088
KASUMI6	CCLE Cell Line Gene CNV Profiles	1.0	3.21041
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZM-0126-SM-3DB8M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934063
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.940548
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
GSE178340_7_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.928
ETS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00800486
EZH2	ENCODE Transcription Factor Targets	1.0	null
BRD-K54134201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49998
PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209041
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07504
BRD-K93472147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61463
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229698_1_v_2_traf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599361
FOSL2	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.91085
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16656
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18561
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.950975
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CDCA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0093107
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.881412
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.529
GTEX-QDVN-0326-SM-2I3FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862031
SKMEL5_SKIN	CCLE Cell Line Proteomics	1.0	3.92203
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.99299
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K37900095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13463
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445639
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
BRD-K24565713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20948
periventricular stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12921
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7S9-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
propoxycaine-7155	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Heart Diseases	CTD Gene-Disease Associations	1.0	1.12117
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959344
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.657737
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE240109_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-55-WK61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382207
NCIH1963	CCLE Cell Line Gene CNV Profiles	1.0	1.56368
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54711
BRD-K75869095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04004
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Entorhinal area, medial part, dorsal zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36553
Benzo[a]pyrene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1226-SM-3GACY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12811
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13493
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO Biological Process Annotations 2023	1.0	null
TLR8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00755001
SMAD3-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
meglumine-3068	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6898
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
than	GeneRIF Biological Term Annotations	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.923826
HOXB9_02_15	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59383
SW1271	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76033
BRD-K27543887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43391
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75772626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87219
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasm	GeneRIF Biological Term Annotations	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.65098
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883729
BRD-K81997160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22975
CA-73-BW50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303551
liminal part of the r9 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10298
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Psoriasis vulgaris_Skin tissue_GSE6710	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.58251
PUS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40058
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.58555
Brain Lower Grade Glioma_LGG_TCGA-HT-7604-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221038
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47193
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13207
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244659
BRAF_druginhibition_38_GDS5085	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.94777
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40794
BRD-K69699301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01747
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PINK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654931
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71265179_Carbazol-9-yl-p-tolyl-methanone_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7QW-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54265757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0181
BRD-K42138859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87137
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31665
CIITA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492117
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97759
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59587063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69254
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K79me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NUMA1	MSigDB Cancer Gene Co-expression Modules	1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293249
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.825809
Cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.585
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44944
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45047
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
BRD-K05789358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05545
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28320832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36653
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041229
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869911
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051156
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0722
BRD-K97682096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43446
Sarcoma_SARC_TCGA-PC-A5DM-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z4-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44092
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226695
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.893339
VCAP	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.2521
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-BRCA1_448_TCF7_rep1_sorted_peak-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.827507
BRD-K61485947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40475
substrates	GeneRIF Biological Term Annotations	1.0	null
Orbital area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04651
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.66343
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940972
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J7-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2544_EIF3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526137
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
16818684-Table2b	GeneSigDB Published Gene Signatures	1.0	null
BRD-K29415052_NVP-BGT226_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169286
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_18_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0926-SM-2TF56	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915189
K562_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183919
BCLAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29383520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34742
LS513	DepMap CRISPR Gene Dependency	1.0	4.40463
rent1_15448691_hela_lof_human_gpl8300_gds705	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.040314
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38131
K562_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192405
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S12-Table_S12_MR_resluts_of_brain_pQTL_and_any_ischemic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
2548_EIF3D_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.587537
MYC	ChEA Transcription Factor Targets	1.0	null
autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.872053
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
BRD-K20984459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04124
Exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.718
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975323
magnocellular superficial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22561
adult testis	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.10591
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44785
BRD-A92357389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75688
Lung adenocarcinoma_LUAD_TCGA-44-2655-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chr13_114298948_G_A_b38	GTEx eQTL 2025	1.0	1.09355
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34868
BRD-K15442833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03131
GSE250089_0_v_3_epcam_human	RummaGEO Gene Perturbation Signatures	1.0	null
exon-exon junction subcomplex mago-y14	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.922
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16711
gossypol-6058	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.539
ABC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64876
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TOP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07917
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.92559
H3K9ac_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321503
HCFC1	ENCODE Transcription Factor Targets	1.0	null
PAX5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843827
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
Calu-3	GDSC Cell Line Gene Expression Profiles	-1.0	-2.35436
junctions	GeneRIF Biological Term Annotations	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128076_1_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.02047
KDM5B	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051156
CRCGN013_HEPG2_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0667
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535313
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45817496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85526
ZBTB33_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
K562_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179057
K562_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306641
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039621
H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51985
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52083
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059475
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
253JBV	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80926
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911088
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16399
hsa-miR-4282	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040801
Nucleolus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
RBM8A	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_AC480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0266661
BRD-K62982533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27957
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188976
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDC16	MSigDB Cancer Gene Co-expression Modules	1.0	null
K562_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162332
Sarcoma_SARC_TCGA-X6-A8C5-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UNC2881	DeepCoverMOA Drug Mechanisms of Action	1.0	0.72
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56912
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63484
intermediate stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12384
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13927
ATP2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533777
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53129
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42787
A549_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121942
PLPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539588
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10712
LMO2	ChEA Transcription Factor Targets	1.0	null
BRD-A71722688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22474
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	4.88343
GSE155031_6_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1195	CCLE Cell Line Gene Expression Profiles	-1.0	-1.92217
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25042
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89432538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85019
biological_process	GO Biological Process Annotations 2015	1.0	null
TYK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504173
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SW403	CCLE Cell Line Gene CNV Profiles	1.0	1.63037
MET_knockout_261_GSE8747	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63748
BRD-K56381552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60261
GSE178340_1_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.35444
organelle part	GO Cellular Component Annotations 2015	1.0	null
BRD-K76508844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12265
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15084
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02384
MDA MB435	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.43667
BRD-K00509345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34815
periventricular stratum of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15593
GSE218727_0_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A27080191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84433
BRD-K31536290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36533
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60511
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.953782
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-484	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
RAD21_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Axon guidance	Reactome Pathways 2024	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A707-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mephentermine-3425	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42663
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
TC32	CCLE Cell Line Gene Expression Profiles	1.0	1.53316
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02207
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939135
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.880456
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Silique	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.215
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
3042_FCF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.580701
K562_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016847
thrombocytopenia-absent radius syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
Sarcoma_SARC_TCGA-DX-AB2F-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39236
Aorta	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.0383
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19387722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76408
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208081
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.84266
KCNN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00686905
lateral periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03185
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66082
RNA-directed RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.724
BRD-K65410345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73226
BRD-K88003497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79282
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041753
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.850165
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEACAM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564696
GATA3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29415052_NVP-BGT226_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8479-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20227
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thrombocytopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.274732
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843827
dizocilpine-6223	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K47878187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40947
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209791
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09638
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38489
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19269952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40208
GTEx Skin 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	5.97555
exon-exon junction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.349
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.867418
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04174
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.4582
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6228-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of amide metabolic process	GO Biological Process Annotations 2023	1.0	null
POLE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774853
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64717502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59528
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11898
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.839706
BRD-K74500173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2469
SERPINE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605849
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.38418
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01815
diflorasone-2798	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HT-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.85
BRD-K62577212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02377
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K57169635_dacomitinib_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984755
Acute Myeloid Leukemia_LAML_TCGA-AB-2877-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ENTPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4305
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907578
BRD-K27406233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21247
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03873
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K19702946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00577
BRD-K13619800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46607
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.831538
BRD-K75136523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16926
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3977	TargetScan Predicted Conserved microRNA Targets	1.0	0.119151
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832603
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8359
BRD-K75293299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03644
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
CDK4_knockdown_133_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.39225
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150302
Translation release factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.239
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.972238
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10479
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.764
testis	HPA Tissue Protein Expression Profiles	1.0	1.255
Metabolism of RNA	Reactome Pathways 2024	1.0	null
periventricular stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34831
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS6KA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655512
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.903366
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.957057
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.87705
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522843
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02771
BRD-K07667606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32768
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TYK2_knockdown_35_GDS4754	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.13334
phenindione-2868	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K13330525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09807
EMD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00725194
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9842
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30530468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82297
BRD-K78306305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64417
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.547761
mantle zone of r10BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01252
pallidal amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61199
K562_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203283
pyramidal layer of IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58292
BRD-K88317944_VU0420364-1_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.14573
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31832
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
zinc acetate_homo sapiens_gds1617	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC3371315-NIHMS350140-supplement-9.xls-MCF7-T47D-SK-453_Up_MCF7-T47D_x-Supplementary_Table_2_ER-positive_FOXA1_signature_Genes_increased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
PRPSAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19963
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.836979
methotrexate_homo sapiens_gpl570_gse11440	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01259
Anemia	CTD Gene-Disease Associations	1.0	1.16733
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.727748
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDST8	DepMap CRISPR Gene Dependency	1.0	2.39828
BRD-K76677554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05519
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17002
EGR1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7537_RPS7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51351
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.732596
RAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00772602
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548504
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49171
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.515141
RO82-W-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43616
CDK7_knockdown_124_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.34346
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5244
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24818
GSE178714_3_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12486367-Supplementary_Data2.pdf-490-ZBTB22_ZBTB22	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A09115727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09395
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37217
TAF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16091
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32749
BICR56	DepMap CRISPR Gene Dependency	1.0	2.58706
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42P-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior temporal gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18108
PPP1R12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10371
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenosquamous carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.334
decay	GeneRIF Biological Term Annotations	1.0	null
GSE239541_11_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05979
r2 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00229
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.68476
H3K27ac_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92404
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14885
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
ASF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59462
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.63018
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Moxonidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
citiolone-3930	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REEP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16089
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.841433
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.734195
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE126463_4_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0284976
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
5557_NDUFB5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554331
mepenzolate bromide-2169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.606381
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31062
H-1152	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51796
NCI-H250	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
RANBP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0438
CAVIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00498504
MYC	ENCODE Transcription Factor Targets	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32137
Bacterial Infection_Peripheral blood mononuclear cell_GSE3026	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.57538
establishment of rna localization	GO Biological Process Annotations 2015	1.0	null
Gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05737
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21857
Eukaryotic translation initiation factor 2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.194
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
TAL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
PRKAA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00655175
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11250262-41588_2024_1798_MOESM4_ESM.xlsx-ST18_665_top_menarche_genes-gene_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4706-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS53	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49928
RVH421	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66984
BRD-K25638876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07349
5255229-833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9842
19074895-Table3	GeneSigDB Published Gene Signatures	1.0	null
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Retrosplenial area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18905
Perturb_15062_OE_Trp53_SRP345823	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.83069
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78632
KYAT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00672246
WAPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17754
oxybenzone-6309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K29320859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24476
GATA1	ENCODE Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.888533
BRD-A06327019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06717
r9 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06676
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.827497
RL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K54814515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25083
RQC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.493
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.26713
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Developmental Biology	Reactome Pathways 2024	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A614-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.956927
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44971
LARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64015
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.705405
TSHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679359
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A20305532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.28827
BRD-K78809123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35558
GTEX-X8HC-0726-SM-46MWG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00319
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLCNKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00742083
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A267-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G6-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426132
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.83059
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXB13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548169
WSU-FSCCL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05081
NFATC1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral (dentate) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09838
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC7A9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006535
K562_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247237
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20743
Cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05975
vagina	HPA Tissue Protein Expression Profiles	-1.0	-1.31276
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54426
CRCGN013_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66269
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.22994
GTEX-S4P3-0226-SM-3K2BD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11899
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1	ENCODE Transcription Factor Targets	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.42943
RAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06112
GSE175571_3_v_2_acsl6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20605
nucleus	GO Cellular Component Annotations 2025	1.0	null
CEP83	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00686838
BRD-K81266242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05821
superficial stratum of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22387
RXRA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4677-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.61421
Cytosolic ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.918
BRD-A34492468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11837
BRD-K56234278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55919
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10237
TAL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
abnormal testis morphology	MGI Mouse Phenotype Associations 2023	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48531
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172651
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10583
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SCHNEIDER-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.949
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2291	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59129
VAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09175
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09536
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168233
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-YY1_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82559
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78N-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88467167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2421
ARPC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28172
AML - Acute myeloid leukemia_Mononuclear Leukocyte_GSE2191	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.187492
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NELFA-20434984-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K56870337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07021
t-UTP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.514
MAPK11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04896
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13207
p1 part of the substantia nigra reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14695
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FC-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172016_2_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.868445
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE187006_0_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU878	CCLE Cell Line Gene Expression Profiles	-1.0	-2.79977
valproic acid-5219	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33737
SARS-BatSRBD_60Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.94393
H3K36me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
DMRT1	ChEA Transcription Factor Targets	1.0	null
BRD-K24532680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56941
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P78B-0526-SM-2I5F7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915868
HCT116	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.24774
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-A36171447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02541
TACC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29954
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chlorprothixene-2627	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11757577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76076
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2486
BRD-K97362312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80411
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ7-mel	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4876
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14041
GTEX-PX3G-2626-SM-2I3EG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15039
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229138
ABCG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512397
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EPHA4_drugactivation_229_GSE26523	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.4631
BRD-K73095160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43107
GSE89767_7_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158901
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRTCAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.007932
BRD-K41876347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77133
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29R-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB33_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02392990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.70749
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-381	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K27726368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12679
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908307
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.53946
intermediate stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02702
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.893792
DOK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00418789
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
U2-type spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.068
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
CMK86	CCLE Cell Line Gene Expression Profiles	1.0	1.39104
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957785
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5274
PTPN11	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4676
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-468	GDSC Cell Line Gene Expression Profiles	1.0	1.42919
U1 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.31
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
fusaric acid-3245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Histone mRNA stem-loop binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.775
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.868007
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAL1	ChEA Transcription Factor Targets	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
buspirone-2637	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.863453
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
enoxacin-5616	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A7UV-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC22A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490787
PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_21-Supplementary_Table_21_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_TCGA_cohort_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
Barrington's nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07685
Lung adenocarcinoma_LUAD_TCGA-75-6214-01A-41R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564191
Small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.854
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.928674
SLVL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051024
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.80342
hsa-miR-466	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852977
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4814-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-34-TG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292345
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.597375
BRD-K09376957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41571
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANKRD22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00446874
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.03102
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92695
BRD-K72609445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79048
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K97617600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3364
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197742
GTEX-PSDG-0726-SM-2I5FN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02303
NCIH1836	CCLE Cell Line Gene CNV Profiles	1.0	1.44366
BRD-K96254487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40237
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977014
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K32444429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02544
psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.232142
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68174511_torin-2_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
participate	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-767-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
KDM2B-26808549-CHIP-SEQ-HPB-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-0.919819
BRD-K70870890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43604
BRD-K54751293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19183
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55835264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92806
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.825474
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.877585
ALDH1A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537915
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.891715
U5 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.703
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75453159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1352
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222124
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-0.755756
nonsensemediated	GeneRIF Biological Term Annotations	1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.928635
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.997898
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S2-Table_S2-MECOM_network_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.853989
BRD-K10181552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.7243
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10214295-mmc4.xlsx-B_-_Beta_Cell_ZBTB16_targets-Ensembl_Gene_ID_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-72-JV60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218334
GSE137137_1_v_0_rcor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21922
BRD-K23197669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79695
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188693
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8Q8-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2749_KO_STING1_SRP358852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93803
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCILY19	DepMap CRISPR Gene Dependency	1.0	2.50845
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5034
DNA polymerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.596
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A204	BioGPS Cell Line Gene Expression Profiles	1.0	1.22669
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.03464
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4652-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
domains	GeneRIF Biological Term Annotations	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875874
K562_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018423
GTEX-S7SF-0226-SM-3K2BI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923709
BRD-K66717300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05599
Polytene chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.563
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95810752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29613
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99783492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.104
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92245
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16297
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
nuclear lumen	GO Cellular Component Annotations 2023	1.0	null
sno(s)RNA-containing ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.744
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S4-Supplemental_Table_S4_Genes_commonly_upregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
EXOSC2	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862027
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Translation initiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.493
DRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04404
TRIM21	Hub Proteins Protein-Protein Interactions	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRTN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520164
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61178
BRD-K53552465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45541
BRD-K83090041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28633
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77664
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.0168
PMC6745489__F5	PFOCR Pathway Figure Associations 2023	1.0	null
Chromosome 1q21.1 duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.846
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0092
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39463
BRD-K74568352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07322
hsa-miR-4714-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Translation repressor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.259
Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Protein phosphatase type 2A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.747
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.542827
BRD-K89574562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32721
BRD-K77733130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00963
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82003
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137321
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.01143
SREBP2-21459322-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SN8G-1526-SM-4DM79	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955218
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11765
DE-99-OT37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206958
Weight Loss	CTD Gene-Disease Associations	1.0	1.03046
Idiopathic pulmonary fibrosis disease specific cell type	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.301
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MH-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LC-1F	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71298
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922892
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A	ENCODE Transcription Factor Targets	1.0	null
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88667
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.804478
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC5848610-supp_gr.228809.117_Supplemental_Table_S3.xlsx-Table_S3F-Supplemental_Table_S3F_ZFX_binding_pattern_clustering_information_for_genes_with_promoters_bound_by_ZFX_related_to_Figure_2I_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37382
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.947386
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09222
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.833
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19211
drofenine-7129	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
periventricular stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62718
aromatic compound catabolic process	GO Biological Process Annotations 2015	1.0	null
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20789
K562_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169056
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.57823
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05611
central amygdaloid nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03185
GTEX-SIU8-0626-SM-2XCDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14883
BRD-K64451677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60244
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24387453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60406
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.57661
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.30212
SNU668	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05492
BRD-K30643363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82492
BRD-K51666223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33421
Hybridoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.367
NXF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04371719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15435
Nuclear envelope lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.83
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAB10	MSigDB Cancer Gene Co-expression Modules	1.0	null
aciclovir-5278	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cyclophosphamide_homo sapiens_gpl8300_gse7114	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75291
CCR6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544416
K562_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200918
TOV-21G	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FASTKD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490793
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502347
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04913
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01638
Cdc73/Paf1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
r6 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13215
SCC4	DepMap CRISPR Gene Dependency	1.0	4.96543
GTEX-XLM4-0726-SM-4AT64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10643
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888594
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.13613
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594458
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80036
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYL9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502614
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
XRCC5	MSigDB Cancer Gene Co-expression Modules	1.0	null
hsa-miR-520f	TargetScan Predicted Conserved microRNA Targets	1.0	0.119151
ZBTB33_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1563	CCLE Cell Line Gene CNV Profiles	1.0	1.50074
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17902
PSMB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553933
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ETS1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Testicular cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.082
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223278
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36357
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257879
blood coagulation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.090082
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.85803
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43343
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.70107
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31694
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0569
GTEX-WXYG-0226-SM-3NB2Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943706
SP4	ENCODE Transcription Factor Targets	1.0	null
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824692
Eptifibatide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
eucatropine-3935	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2023	1.0	null
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSF1R_druginhibition_195_GSE57686	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.76394
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19494
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_2day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.84869
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28179
GATA3	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Sec62/Sec63 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.89
BRD-A19037878_trichostatin A_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A88691416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06773
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67197
BRD-K15907840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97235
BRD-K45073068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51662
SAP30	ENCODE Transcription Factor Targets	1.0	null
hMPV_72Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.33301
r2 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21693
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6231
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21065
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19465
BRD-K15977595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27035
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975323
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4470_KRI1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.871547
CALCA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00390772
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39537
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533032
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193027_1_v_0_krt19_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS6KL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05716
Immunodeficiency 51	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD4-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.869064
mantle zone of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09784
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92754
BRD-K70305913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13835
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14533
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.853989
PAX5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC22A23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524997
K562_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248067
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.04366
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00635
Transcription export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.46
yy1_20215434_hela_lof_human_gpl570_gds3788	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.428951
mantle zone of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23791
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79090631_CGP-60474_HCC515_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6050_PAM16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.720297
BRD-K96560179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33123
BRD-K43782839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26744
ZFP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13246
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22749
K562_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166418
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00065
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4152
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45503
BCL3	ENCODE Transcription Factor Targets	1.0	null
BRD-K11610091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9637
RGS12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00723845
rna metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60306319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02622
export	GeneRIF Biological Term Annotations	1.0	null
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24216
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94149
BRD-K03214579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82909
Dorsal column nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3176
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.202456
BRD-K98164803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57595
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79193
AC-31-PL89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302405
STAT5A	ENCODE Transcription Factor Targets	1.0	null
PTK7_KD_GSE50138_674_human_H1299	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K36190163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68932
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.914406
BRD-A42030853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26404
KO52	CCLE Cell Line Gene CNV Profiles	1.0	1.50878
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43803
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4989-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UACC-812	GDSC Cell Line Gene Expression Profiles	-1.0	-1.64931
TRIM35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32201
BRD-K63626200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59923
BRD-A20213616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11527
Dom34-Hbs1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.641
Microsporangium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.552
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0497
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04798
Cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.008
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230067
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02708799_GSK-1059615_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67150949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60029
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07044
lobeline-6258	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LXF289_LUNG	CCLE Cell Line Proteomics	1.0	2.98637
KLF5-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26962
BRD-K12347309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10068
BRD-K68492420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73989
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
ZBTB33_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43019
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.854839
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.76912
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54711
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03309
IZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09105
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5154
HDAC8_02_51	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59012
BRD-K56488838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44973
Pelger-Huet anomaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16561
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13264
GRIK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633596
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07933
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4875-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	-1.0	-2.5064
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4431731-pgen.1005211.s002.xlsx-ERG_TRISOMY-Unnamed_2_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
RAD51D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1042
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.26852
GTEX-X585-0426-SM-4E3JZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827709
GTEX-U4B1-0626-SM-3DB8L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933041
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K33371292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26585
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
TCF3	ENCODE Transcription Factor Targets	1.0	null
BRD-A58048407_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
r4 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55358
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041445
GTEX-T6MN-0626-SM-32PM9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00357
GTEX-X4XY-0826-SM-4E3JM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15321
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41A-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thyroid cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.084
GSE160373_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2246
SPATA33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00735
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04686
plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-S32W-1326-SM-4AD5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05117
periventricular stratum of r8Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48527
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20863
BRD-K75440064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89043
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31004
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.13838
famprofazone-2174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K58112932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53852
Perineuronal net	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.875
mepenzolate bromide-6024	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67L-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143237
PPIF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01395
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SS-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8424-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K86158100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45407
NCI-H1092	GDSC Cell Line Gene Expression Profiles	1.0	1.55523
ventrolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14393
BRD-K74767736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02124
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nidopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.638
Probenecid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
NB10	DepMap CRISPR Gene Dependency	1.0	2.7758
mrnp	GeneRIF Biological Term Annotations	1.0	null
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43717
FAM32A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20168
cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03093
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16061
9303_TRMT112_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508864
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.942
heliotrine-2180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PKM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46932
Fetalbrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.990125
Retrosplenial area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00766
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gly-His-Lys-6560	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEC50B	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52033
Midgut epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.831205
BRD-K07160586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.091
CHD2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear part	GO Cellular Component Annotations 2015	1.0	null
BRD-A30758703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28616
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TSLP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583735
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUDHL6	CCLE Cell Line Gene Expression Profiles	1.0	1.70587
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HF-25-LA47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220942
Uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.955
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS2_2019_Affy_IDs_SignalsQN-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
nuclear-transcribed mrna catabolic process, nonsense-mediated decay	GO Biological Process Annotations 2015	1.0	null
RNF2	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A50287893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52987
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894367
K562_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0284295
DMS79	CCLE Cell Line Gene CNV Profiles	1.0	1.57999
GPR87	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501276
BRD-K48691065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4422
PPP1CC	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZG-0226-SM-2TC5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03237
PMC10214295-mmc4.xlsx-B_-_Beta_Cell_ZBTB16_targets-Gene_Name_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0723
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S14-Table_S14_MR_resluts_of_brain_pQTL_and_cardioembolic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
binds	GeneRIF Biological Term Annotations	1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.212
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73200916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36771
CORL88	CCLE Cell Line Gene Expression Profiles	1.0	1.43814
BRD-K13817284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35129
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE171572_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526879
metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.444558
Rpd3L-Expanded complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
GSE149123,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.606021
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15279
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160032
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A06158172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43571
BRD-K91421454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89713
periventricular stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01252
guanabenz-1961	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_1_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AT-A5NU-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40692
BRD-K84060528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38726
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.65036
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.593398
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863981
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385853
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37755
HPAFII	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22415
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42842
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96383
U87MG	DepMap CRISPR Gene Dependency	1.0	3.27178
BRD-K75067815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01445
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPN-0011-R9A-SM-4DXUH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939655
HDAC2	ENCODE Transcription Factor Targets	1.0	null
DPP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528781
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25123
BRD-K89121101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58962
BRD-K47673408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00091
MTDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17553
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48197
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.841375
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73Q-01A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9175_TOP2A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.54103
BRD-K98953346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54894
APOBEC3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629781
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.067
Cpa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.531
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567078
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHRDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24296
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08016
BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055138
KCNJ12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487989
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleocytoplasmic transport	GO Biological Process Annotations 2015	1.0	null
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19686
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04958
BRD-K47849061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27762
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92712671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14047
496100618_PCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34905
GSE233183,GSE233187_2_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GFI1B	ChEA Transcription Factor Targets	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30474
tiletamine-6013	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PC-18-VX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224373
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054544
LC1SQSF	CCLE Cell Line Gene Expression Profiles	-1.0	-1.9795
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A69P-06A-21R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K66089377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44452
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45879
HCC1833_LUNG	CCLE Cell Line Proteomics	1.0	5.3722
hsa-miR-127-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37645
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29692
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.015
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26046
Medial amygdalar nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17652
Abemaciclib_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0167375
BRD-K20624967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25629
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X638-0426-SM-47JY2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10747
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846127
HUH6	DepMap CRISPR Gene Dependency	1.0	2.40441
SP3_Deficiency_GDS3058_610_mouse_Embryonic heart  (day 12.5 C57Bl/6)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-2.09938
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.918537
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160618
organelle	GO Cellular Component Annotations 2015	1.0	null
K562_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225706
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28607
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43103
9602_UPF3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.804172
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172709
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
NCIH1792	CCLE Cell Line Gene Expression Profiles	-1.0	-1.4923
PSG8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00511471
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253055
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9253
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419297
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040994
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230263,GSE230265_0_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26622
Factor X deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Intercalated amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08725
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73506
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64254
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ribonucleoprotein granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.299
BRD-K92991072_PAC 1_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281636
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15932
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040964
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36811
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89451
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29415052_NVP-BGT226_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26976202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37237
GTEX-X638-0226-SM-47JZ9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841839
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16376
NCIH522	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67684
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSNK1D	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42525
BRD-K11404512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14995
Lung adenocarcinoma_LUAD_TCGA-69-8253-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14767
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_ALL-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K48756106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0157
Adventitious root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.24722
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.882701
CEBPB	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K05409106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5604
SHI1	DepMap CRISPR Gene Dependency	1.0	4.85234
PTPRK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00498686
macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
E2F4	ChEA Transcription Factor Targets	1.0	null
iobenguane-2878	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XMK1-0626-SM-4B65A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13378
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21871
NPBWR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480434
K562_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195329
Granular lamina of the cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46301
BRD-A45607610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16437
SC-19220-7095	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.02228
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96389533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53424
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99528
lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.399114
prilocaine-3624	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatal amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10822
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.68966
A549_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262143
HIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04205
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO Biological Process Annotations 2025	1.0	null
MSLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03314
Ubp3-Bre5 deubiquitination complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB33_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171728
esculetin-6499	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15930345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51733
superficial stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03185
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.31255
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34789
HAO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575213
BRD-K09598619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03959
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51233
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57253
BRD-K70594121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24912
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
less	GeneRIF Biological Term Annotations	1.0	null
RXRA	ENCODE Transcription Factor Targets	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48056188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45158
SLC29A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658324
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ullrich congenital muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.464
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCYT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598007
regulated	GeneRIF Biological Term Annotations	1.0	null
Anterior cingulate area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04651
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00433
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K97122937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48382
BRD-A07214340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29492
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71113
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63568016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19247
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anagrelide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
nucleolus	GO Cellular Component Annotations 2025	1.0	null
Vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.542
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39882
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02324
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.588893
establishment of localization	GO Biological Process Annotations 2015	1.0	null
LTF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633197
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16268
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29629
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51034
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71298594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65186
HCC33	CCLE Cell Line Gene Expression Profiles	1.0	1.67857
BRD-K49419779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02214
TRAF3IP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584622
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.876109
Agranular insular area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69308
H3K36me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.666379
UBA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08397
ZBTB33_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15766
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.859513
BRD-K76861469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17288
Choroideremia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
K562_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182556
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59082
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00793226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09261
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1624
CTCF_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CACNG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689939
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.36176
BRD-K74870161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04026
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIRT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00410117
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22454
OV-17R	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7295
BRD-K08427390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01391
UACC-62	GDSC Cell Line Gene Expression Profiles	-1.0	-1.82238
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80794
mrna transport	GO Biological Process Annotations 2015	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.465444
SKMEL3_SKIN	CCLE Cell Line Proteomics	1.0	8.26436
ventrolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.846266
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
Rett syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
BRD-K28319429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26726
Perturb_4572_KO_Pwwp2a/Pwwp2b_SRP255880	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.36628
K562_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171478
PMC11960529-mmc4.xlsx-Ventricular_ZNF711_KOoverCT-gene_ZNF711	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43789905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08826
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50803
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.55639
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11602576-mmc11.xlsx-ST12-Table_S12_Output_of_mash_model_of_milk_and_GTEx_eQTL_effects_Related_to_Figure_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
SNU1	DepMap CRISPR Gene Dependency	1.0	2.75962
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18748
BRD-K01121723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01618
AC-75-LR63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213291
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41967
BRD-K54066059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48845
496100612_HIP_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64322
PL21	CCLE Cell Line Gene Expression Profiles	1.0	1.4942
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.850165
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10W-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.69337
GATA3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32021110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07051
TC71_BONE	CCLE Cell Line Proteomics	1.0	2.91357
WB-82-EL69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206992
ZBED1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3545
Hematologic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
BRD-K59191599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11654
A549_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147731
TSSK1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528552
RCC10RGB	CCLE Cell Line Gene CNV Profiles	1.0	1.89438
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.765943
RIOK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569444
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
pyramidal layer of taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17223
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77820593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87408
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56429665_Calcipotriol_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Arsenic	CTD Gene-Chemical Interactions	1.0	null
hupf3a	GeneRIF Biological Term Annotations	1.0	null
EVSAT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93927
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881336
suxibuzone-5806	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37515001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33091
primary auditory cortex (core)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15164
C33A	DepMap CRISPR Gene Dependency	1.0	3.17947
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09047
pridinol-5860	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r2 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14695
nucleus of diagonal band	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.851034
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227624
SPI1	ChEA Transcription Factor Targets	1.0	null
BCL3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63449
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
WERIRB1	DepMap CRISPR Gene Dependency	1.0	4.31353
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842592
ZNF276	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061634
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36772
PMC11263679-41598_2024_66946_MOESM1_ESM.pdf-67-SLC2A4RG_SLC2A4RG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A84695402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50479
GSE178340_1_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Polytene chromosome puff	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
thyroid	GTEx Tissue Gene Expression Profiles	1.0	1.72375
NCIH838	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45954
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054473
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
BRD-K82842087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81956
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TET1-21451524-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE229978_4_v_7_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K68594161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54636
BRD-K22875057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65751
GSE196540,GSE196542_4_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cinchonine-2133	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25353
JSC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZBTB33_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11651
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58923
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929043
SREBF2	ChEA Transcription Factor Targets	1.0	null
hsa-miR-760	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K86371068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28652
UGCG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515792
KMRC20_KIDNEY	CCLE Cell Line Proteomics	1.0	3.22548
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K45908502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20458
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.887678
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M8-01A-21R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8891017-41586_2022_4394_MOESM4_ESM.xlsx-ST6_-_MAF_enrichment-Unnamed_4_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K53104784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1777
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52587
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Transcription preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.253
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZE-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
15902281-TableS1c	GeneSigDB Published Gene Signatures	1.0	null
GATA6-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE158320,GSE183351_0_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
orciprenaline-2845	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K42123500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06249
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3682-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44569
Hip circumference adjusted for BMI	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5X1-0426-SM-3GILB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19422
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972455
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.05694
BRD-K72098698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86267
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.227445
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33593
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.22048
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16176
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.922468
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GAPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539811
P-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.258
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63W-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-520e	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
DLG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531698
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.657275
YAMATO	DepMap CRISPR Gene Dependency	1.0	2.69121
BRD-K12743035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15501
RXRA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stimulate	GeneRIF Biological Term Annotations	1.0	null
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
male infertility	MGI Mouse Phenotype Associations 2023	1.0	null
anterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10658
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33592
UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153436
BRD-K26852477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39839
Lymphatic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217863
CENPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12943
BRD-K70854630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60213
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5868
superficial stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21525
vidarabine-5850	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Chicago Sky Blue 6B-4971	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CBL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061487
Perisynaptic extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.872
BRD-K76401790_JNK-IN-5A_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO800	DepMap CRISPR Gene Dependency	1.0	2.30249
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14405
OAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624527
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NEUROD2-26341353-CORTEX-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29149
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246762
20101236-Table2	GeneSigDB Published Gene Signatures	1.0	null
Macrogamete	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.993
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3188
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.76797
retropontine reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12565
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60162
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K30172718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01205
PMC11953091-12035_2025_4695_MOESM1_ESM.xlsx-s5-Supplementary_Table_5_Results_of_the_2-sample_pQTL_MR_on_insomnia_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
LILRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00802111
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835928
Mpp10 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.935
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26388
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.604406
GSE153189_1_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52783
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.643183
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBMS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00717807
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WL46-0126-SM-3TW8I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923464
K562_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016005
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.952431
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
6963_PWP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.535128
ID2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00391976
MYOD1	ENCODE Transcription Factor Targets	1.0	null
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481598
gp2d	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.686
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93933512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.957956
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.679377
K562_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158329
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TTF2-22483619-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68194
GTEX-WYBS-1926-SM-3NM8N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93375
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0139
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18505
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE195559_3_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8573
pyrantel-2260	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2BK15ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MONOMAC6	CCLE Cell Line Gene CNV Profiles	1.0	1.38386
BRD-K76755209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86055
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.20403
REST	ENCODE Transcription Factor Targets	1.0	null
MON	DepMap CRISPR Gene Dependency	1.0	3.80616
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
16397240-SuppTable9	GeneSigDB Published Gene Signatures	1.0	null
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EGR1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548l	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195559_3_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal testis morphology	IMPC Knockout Mouse Phenotypes	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
VMRCRCW	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36466
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K38929751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20441
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09262
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24347
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46797
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2341
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.31276
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RUNX1	ChEA Transcription Factor Targets	1.0	null
island of Calleja major	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39236
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973095
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.2783
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86337
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03432
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FADU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K49669041_HY-11005_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
Parastrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01252
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13844473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38857
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966769
Protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.638
Ezh2_KO_GDS3765_515_mouse_Primary preadipocyte cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1213
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53886
Catalytic step 1 spliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.747
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
layer 1 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01655
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.83206
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sporangiophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.194
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
SYK_druginhibition_284_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.20157
upf2	GeneRIF Biological Term Annotations	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-94-GN01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210769
r10 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44476
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Shoot tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.927
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.7099
A549_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144982
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.59194
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61G-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
DKK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654564
Signal recognition particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.079
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979524
Trypanosomoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.529
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826905
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4225
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178714_6_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RNA polymerase V complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.83
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01392
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
vorinostat_homo sapiens_gpl571_gse18544	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ozagrel	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3027_KO_Hif1a_ERP124464	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.47558
r8 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0618
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.56665
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
QA-34-PH05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22041
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166807
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
HCC1419	DepMap CRISPR Gene Dependency	1.0	3.6359
TALL1	CCLE Cell Line Gene Expression Profiles	1.0	1.56453
blood platelet disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.221108
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20101
GTEX-WOFL-0726-SM-3MJG4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88677
heart_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.08884
LF2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.328
K562_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207336
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72624
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70889
18381933-SuppTableS4	GeneSigDB Published Gene Signatures	1.0	null
BRD-K70145120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67391
SIK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00803273
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12181036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34721
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
COV362	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68071
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6591
BRD-K62572662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58389
2790_EXOSC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.729457
GTEX-TSE9-0626-SM-3DB8B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11952
transport	GO Biological Process Annotations 2015	1.0	null
much	GeneRIF Biological Term Annotations	1.0	null
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X4-01A-51R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907138
hsa-miR-655	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.12827
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48099
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K28795679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21596
bemegride-3389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
asiaticoside-2943	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.935939
PMC8807392-41375_2021_1393_MOESM2_ESM.xlsx-data_integration-YBX1_iCLIP-targets_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chlorcyclizine-2197	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LUDLU1_LUNG	CCLE Cell Line Proteomics	1.0	2.68366
BRD-K12930517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49826
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X5EB-0726-SM-46MVR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976231
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Mucopolysaccharidosis I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.621
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27745
BRD-A89354030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.76523
ACHE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566748
canrenoic acid-7135	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41B-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r2BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00229
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057522
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96213
BRD-K04441230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22282
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156341
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.7294
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0826-SM-2HMKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2669
BRD-K18494310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6213
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4919
embryonic neural stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.791044
positive regulation of cellular biosynthetic process	GO Biological Process Annotations 2023	1.0	null
CVB3_3Hour-Infection_None_GSE697	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.22558
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36045
8656_TAF1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528825
upf3a	GeneRIF Biological Term Annotations	1.0	null
CCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601718
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
TOMM70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16049
K562_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0299096
Leaf disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.695
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.905015
Lung adenocarcinoma_LUAD_TCGA-50-6591-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207231
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.28186
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4981
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.418348
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S11-Table_S11_MR_resluts_of_brain_pQTL_and_any_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1202
interacting	GeneRIF Biological Term Annotations	1.0	null
fusiform gyrus, right, bank of cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.909985
BRD-A21584932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27483
RUNX3	ENCODE Transcription Factor Targets	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81242
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52526
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34459
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
KO52	COSMIC Cell Line Gene Mutation Profiles	1.0	null
zinc acetate_homo sapiens_gpl570_gds1617	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1302
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20651
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857505
HO-1-U-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K70262646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28204
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC6745489__F5	PFOCR Pathway Figure Associations 2024	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.859426
Kidney Chromophobe_KICH_TCGA-KN-8425-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
UBE2E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05448
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861404
tanespimycin-5914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nitrogen compound transport	GO Biological Process Annotations 2015	1.0	null
nuclear	GeneRIF Biological Term Annotations	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7167-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51754677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48098
GE-77-FY84_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.763477
periventricular stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47152
primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15676
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02971
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.05896
oxamniquine-7344	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LE-40-JW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305699
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3064
sulfafurazole-3218	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K48593237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01906
telomeric DNA binding	GO Molecular Function Annotations 2023	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HS-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematopoietic system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82914
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24516
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057237
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.455
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Intellectual Disability	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K49865102_PD-0325901_A549_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ROS50	DepMap CRISPR Gene Dependency	1.0	2.79073
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A31916785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11677
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4224-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retrosplenial area, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05163
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.86215
6793_PRPF31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.685802
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.927492
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
hsa-miR-93	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
acetylsalicylic acid-1145	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
sirolimus-6927	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UMUC16	DepMap CRISPR Gene Dependency	1.0	4.3106
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_HOXC6-gene_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZINC8945	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.45
BRD-K76921877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49487
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.992638
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K36me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1573	CCLE Cell Line Gene CNV Profiles	1.0	1.32955
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911457
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r10 part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.342
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_0_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
positive regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5706-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hodgkin's lymphoma, nodular sclerosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of biosynthetic process	GO Biological Process Annotations 2015	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10734
Fibrosis	CTD Gene-Disease Associations	1.0	1.07696
BRD-K91944762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24461
telomeric DNA binding	GO Molecular Function Annotations 2025	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68857
positive regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-A96334094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49533
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35408
PMC11639743-mmc2.xlsx-LIN28B-gene_name_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
phenazopyridine-5758	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82968130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10912
RBP2_deficiency_GDS2731_62_mouse_embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-4790-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
NCI-H446	GDSC Cell Line Gene Expression Profiles	-1.0	-1.96305
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.111
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S7-MECOM_down_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
CLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17038
SUCLA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556159
2790_EXOSC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.601379
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78388
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.833504
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7569
Bladder Urothelial Carcinoma_BLCA_TCGA-LC-A66R-01A-41R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE246911,GSE246913_4_v_1_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60148
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910749
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRCA1	JASPAR Predicted Transcription Factor Targets	1.0	null
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV44-0826-SM-2S1RG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55906
Perturb_3518_OE_UPF3A_ERP133408	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
todralazine-5087	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.04757
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB33_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34482
GSE228181_2_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.968776
Osteoarthritis_Chondrocyte_GSE16464	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.36149
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MF-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24382357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0869
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K02708799_GSK-1059615_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.971521
RNA binding	GO Molecular Function Annotations 2023	1.0	null
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974765
Central amygdalar nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69432
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A64X-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.951303
hemorrhagic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.178682
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.884414
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
P granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.227
GSE210373_0_v_1_cntnap4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16166618-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02571
RUNX1-27514584-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Bundle sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-20a	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
ARF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677504
TENT4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00381885
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.28199
SB-203580-7061	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48048
7561_RRP12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526488
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0326-SM-3GAE2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26068
GTEX-X4LF-0426-SM-3NMB5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827437
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.995315
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organic cyclic compound catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K64646189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40687
GSE178714_1_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.331
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K73587666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67052
small-subunit processome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.551
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.877048
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nuclear exosome targeting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.68
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5049
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC812	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40137
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876896
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51931
MED13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04381
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.77384
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6129
GATA1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K64451058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20754
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
BRD-K19764912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09465
Lung adenocarcinoma_LUAD_TCGA-55-7910-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Atypical autism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
sulfamethoxypyridazine-3609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
biological regulation	GO Biological Process Annotations 2015	1.0	null
Penis_Foreskin_Melanocyte_Primary_Cells_skin03	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.60155
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-A470-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4965
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65581
schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.233183
Uterine Carcinosarcoma_UCS_TCGA-NF-A4WX-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11013450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59112
GSE86507,GSE86509_7_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF6-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fluorocurarine-5741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260038
Lung squamous cell carcinoma_LUSC_TCGA-43-2576-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACVRL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528342
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	3.19458
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8608
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE186633_1_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
BRD-K60952519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46064
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ookinete	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Amp_AA-TCGA-Unnamed_16_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27143
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33033
Lung squamous cell carcinoma_LUSC_TCGA-MF-A522-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_0_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
imatinib_homo sapiens_gpl201_gds838	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KARPAS620	CCLE Cell Line Gene Expression Profiles	1.0	2.19942
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K14262397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58296
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB33_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152788
positive regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
rosiglitazone-2693	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
homochlorcyclizine-7417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03205303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34175
AE-85-KE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293671
Cytosolic large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.403
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392471
Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CML - Chronic myeloid leukemia_Haematopoietic stem cell_GSE11889	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.58882
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.998105
Nrf2_deficiency_GDS3406_156_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UTP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90841
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.824
streptozocin-5836	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TFAP2A-35110662-HEPM-HUMAN-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3695
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO201	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99033
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55565
chr13_114232601_C_T_b38	GTEx eQTL 2025	1.0	1.25007
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.379295
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.07447
hsa-miR-4766-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
ACT-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.192
STMN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05631
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.700062
BRD-K02299361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18833
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A09243694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34129
intermediate stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42501
mrnas	GeneRIF Biological Term Annotations	1.0	null
SLC18A3_KD_GDS4325_618_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39198
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58399
exon-exon junction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.20189
diethylstilbestrol_mus musculus_gpl6887_gse37969	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K46419649_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190947_2_v_0_xbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC33	CCLE Cell Line Gene CNV Profiles	1.0	2.03459
hsa-miR-4513	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
Messenger ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.182
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	1.0	null
20003503-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE220629_0_v_1_foxp3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7732-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4713_LTV1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.511286
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04986
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.959183
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30293
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.33521
7723_SDHAF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522844
RPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72383
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29415052_NVP-BGT226_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNA nuclear export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.593
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.12008
TROVE2	Hub Proteins Protein-Protein Interactions	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L8-01A-21R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90444258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83344
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.97548
irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.085288
BRD-K32124229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00693
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-A56V-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neuron projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.067201
HT1376	CCLE Cell Line Gene CNV Profiles	1.0	1.76497
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63532
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33287655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14421
EBF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00465692
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39052
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284109
GTEX-R3RS-0726-SM-3GIJR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36563
BRD-K13637593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82083
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LEF1-29337183-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349841
hsa-miR-4789-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
mantle zone of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05163
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A3-KAW	GDSC Cell Line Gene Expression Profiles	1.0	3.02692
benzamil-2200	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE200687,GSE200688_1_v_0_sox15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176211
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04188
GTEX-P4PQ-2626-SM-33HC9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06915
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RPS6KA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00579248
Lymphatic system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
BRD-K69291887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03445
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0359819
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.902191
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CL-40	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975323
EXOSC10	Pathway Commons Protein-Protein Interactions	1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.721308
E2F4-21247883-LYMPHOBLASTOID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01498
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A3JM-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
small testis	IMPC Knockout Mouse Phenotypes	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TestisLeydigCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.36215
SARS-CoV_72Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.27229
posttranscriptional regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22557
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.61616
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91886
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.777
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.878266
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KCNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00771713
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.409577
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5K8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.585
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354451
BRD-A00776891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31881
HIV - Human immunodeficiency virus infection_Peripheral blood mononuclear cell_GSE2171	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.44682
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4919
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150203
SW948	CCLE Cell Line Gene CNV Profiles	1.0	1.97225
K562_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146192
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.586608
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31995
GSE178340_7_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2485
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0426-SM-3GIKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03326
BRD-K24514314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20305
BRD-K33606963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10049
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12032
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2789_EXOSC2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.676354
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47392
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SGS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.202
K562_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156631
hsa-miR-484	MiRTarBase microRNA Targets	1.0	null
FLI1_01_16	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59467
BRD-K54732353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84109
CRCGN017_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15688
mRNA surveillance pathway	KEGG Pathways 2026	1.0	null
outer SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13544
H3K36me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vernakalant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-888	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29211
Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24141
BRD-K62102480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40553
naftidrofuryl-2622	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17462
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07512
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.684272
Pollen mother cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
Hypnozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7779
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.98224
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28429328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51785
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.897761
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.929516
periventricular stratum of r8Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0618
regulation of cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
bufexamac-5090	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRRM1	Pathway Commons Protein-Protein Interactions	1.0	null
CLDN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00685931
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fusiform gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07034
Odanacatib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
Endoplasmic reticulum Sec complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.888
BRD-K55884477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71683
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE193282_2_v_0_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016064
Neuronal ceroid lipofuscinosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
Microcytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.448
K562_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207928
cytosol	GO Cellular Component Annotations 2015	1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21862
K562_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136765
TCF12	ENCODE Transcription Factor Targets	1.0	null
GTEX-WYJK-1626-SM-3NM9J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961058
hsa-miR-488	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WWYW-0826-SM-3NB2X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945292
BRD-K26127722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03723
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.440217
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.997796
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999652
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26137
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Dhori Virus_48Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.21302
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Sporangium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.196
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Calu-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.064
BRD-K45576113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25819
GSE173810_4_v_6_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IP6K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65943
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44946060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1449
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RVH421	CCLE Cell Line Gene CNV Profiles	-1.0	-2.38285
K562_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147732
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00005
SARS-CoV MA15_Day1-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.43112
MST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33441
ETS1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H9 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.20035
BRD-K22039769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10979
r6 part of ventral gigangocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.4315
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860422
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SN-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842959
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96945247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06008
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Torcetrapib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.57
MBIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1744
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09964
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.58165
BRD-K88831197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19876
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01785
exonexon	GeneRIF Biological Term Annotations	1.0	null
BRD-K05261060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25503
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87010860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70156
EKC/KEOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.785
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clopamide-6301	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZBTB33_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84H-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970959
BRD-K58853583_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44126416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21455
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Myelodysplastic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146321
PMC11699082-BLOODA_ADV-2023-012291-mmc1.xlsx-Sheet1-CD37_pos_corr_top100_GSE10846_CHOP_GCB_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.701
Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97625
CTCF-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041611
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.963773
NAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721625
BRD-K39020351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25042
Gracile nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15206
RAD21_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45803
BRD-K75148160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05309
Telomerase holoenzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.954
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913298
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.746496
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
K562_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189126
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Reactome Pathways 2024	1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.23168
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.835003
intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.909376
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.17211
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.855542
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DE-11A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88190816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42838
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.71619
Becker muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0156
RASIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23298
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW948	GDSC Cell Line Gene Expression Profiles	1.0	1.53916
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02539
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear-transcribed mrna catabolic process	GO Biological Process Annotations 2015	1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.902954
CORL311	CCLE Cell Line Gene Expression Profiles	1.0	1.44574
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53659
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87230984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00434
orbital frontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14478
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRKDC	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62364
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7220941-41598_2020_64431_MOESM2_ESM.xlsx-WS1_2019_Affy_IDs_RA-STvsOA-ST-Unnamed_2_PAX3	Rummagene Transcription Factor Associations 2026	1.0	null
etofenamate-7327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32924
GSE137818_5_v_0_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5367
r9 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05163
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.44607
AP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
active	GeneRIF Biological Term Annotations	1.0	null
BRD-K85357344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12043
IL26	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00769737
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Macronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.934
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K11700411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01758
GTEX-RVPV-1226-SM-2TF73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03069
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051384
TTF2-22483619-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RAD23A	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular transport	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00229
K562_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151319
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F2-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Usher syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
a94	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.575
C4orf48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49359
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92643
5762_NPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05627
Posterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33604
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37529
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Meconium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82625
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45632
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234963
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3016
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08219
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-R8-A6YH-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05641
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.692
ERBB3_knockout_239_GSE32129	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.00818
BRD-K14920963_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cyclizine-2880	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TT1TKB	DepMap CRISPR Gene Dependency	1.0	2.20429
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.525316
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6749
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09193
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47496
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.12482
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.891931
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43359161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89184
PAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35661
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870144
BRD-K56034970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38264
pm95	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.371
exon-exon junction complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K97052218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54566
K562_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0341627
K562_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206486
Carnitine palmitoyltransferase I deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleic acid transport	GO Biological Process Annotations 2015	1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
part	GeneRIF Biological Term Annotations	1.0	null
Encysting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319753
GTEX-N7MS-2326-SM-2HMLD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963972
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945634
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
NCI-H630	GDSC Cell Line Gene Expression Profiles	1.0	1.52471
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25512
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bed nuclei of the stria terminalis, anterior division, anteromedial area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07182
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EN-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871593
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.53946
GTEX-S341-0226-SM-2XCAX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02302
hsa-miR-3065-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303697
SUDHL4	CCLE Cell Line Gene Expression Profiles	1.0	1.45549
GSE182680,GSE182683_10_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051982
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
terazosin-2530	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-17-PC87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240242
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nifurtimox-7328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
maintain	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPIC-0226-SM-3GADO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11395
GTEX-R53T-0526-SM-3GADL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85341
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34064
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00238
BRD-A25537246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2889
TRAMP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.21
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10624
BRD-K81925504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5663
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018755
GTEX-S32W-0726-SM-2XCBL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23233
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.77393
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
Lung squamous cell carcinoma_LUSC_TCGA-77-A5GB-01B-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
resolution	GeneRIF Biological Term Annotations	1.0	null
Perinuclear endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.525
CD83	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641363
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.848217
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10043
GTEX-T8EM-0226-SM-3DB7C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991088
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
90S preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.885
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.27171
Set3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.971
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K28140029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47643
Muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
BRD-K14920963_ERYTHROSINE SODIUM_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
transporter activity	GO Molecular Function Annotations 2015	1.0	null
Cytoplasmic ribonucleoprotein granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.295
SUZ12	ENCODE Transcription Factor Targets	1.0	null
BRD-K98201103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61096
Commitment complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.83
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RARB-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0103211
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1355	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57602
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044737
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78394
DU145	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78187
positive regulation of translation	GO Biological Process Annotations 2025	1.0	null
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42758
hsa-miR-302b	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
foliosidine-6057	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20338
BRD-K10460649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1631
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22919
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.14799
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12404
fulvestrant-5969	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.851706
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.854677
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HX-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
idazoxan-3088	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.650447
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32751688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3264
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.35977
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51687
RXRA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100630_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.61394
Levosimendan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
hydrocortisone_homo sapiens_keloid scar_gds3071	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STARD3NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23462
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.837371
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
2791_EXOSC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.636279
TEAD4_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Female pudendum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.189
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.46139
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.920115
DOHH2	CCLE Cell Line Gene Expression Profiles	1.0	1.52918
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JAK2_knockdown_192_GSE54645	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.94982
HMOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4093
RS11846	BioGPS Cell Line Gene Expression Profiles	1.0	2.34695
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K02050740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83785
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842959
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.859
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02249
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.92243
Dorsal motor nucleus of the vagus nerve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40551
Papillary Carcinoma of the Thyroid_Thyroid Gland (MMHCC)_GSE3678	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.32367
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14762
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28833
CTCF_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210105
BRD-A08759443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24548
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198488
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Meiotic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.975
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10362
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAGI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604987
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33751
dienestrol-5727	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K36me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61199
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92893
molindone-4784	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCDC50	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591203
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Methotrexate_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0168303
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PHB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555455
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.47473
positive regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
primary motor cortex (area M1, area 4)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00714
KA-75-LP02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247034
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73572
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02822062_CT-200783_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VC-01A-23R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCNU1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580245
r3 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03255
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAPGEF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00687539
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6141
LY-294002-5596	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IRF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4769
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.871891
BRD-A85860691_chaetocin_A549_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEx Heart 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	3.18866
BRD-K68174511_torin-2_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.02706
Leydig cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-106b	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
BRD-K35441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90863
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22913
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.611737
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE154197_1_v_0_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38839
CTCF_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
BRD-K83125173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0734
RNPS1	Hub Proteins Protein-Protein Interactions	1.0	null
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08802
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
K562_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149883
GTEX-QV31-0726-SM-3GAEG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84724
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510207
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.66937
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017478
pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.814693
ZBTB33_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70158474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12458
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25779
Mucopolysaccharidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW620	BioGPS Cell Line Gene Expression Profiles	1.0	1.01856
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PG-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BLVRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00395568
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193709
Posaconazole_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0133
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DU-145	GDSC Cell Line Gene Expression Profiles	-1.0	-3.53725
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K08799216_pelitinib_SKBR3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.855312
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81751970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52483
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570108
GNG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43145
r4 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24147
Adrenocortical carcinoma_ACC_TCGA-OR-A5LC-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98535230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12255
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146638
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71436
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33613
CRCGN008_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16882
superficial stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76994
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGF1R_druginhibition_47_GSE14024	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.2689
LU65_LUNG	CCLE Cell Line Proteomics	1.0	2.92256
5493_NCBP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.622093
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.29532
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83301
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
RELB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00829881
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387515
Lymphoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26744
GSE139966_5_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZMIZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32533
2,4-Dichlorophenol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.23
496100621_TCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02426
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.980796
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69058
appropriate	GeneRIF Biological Term Annotations	1.0	null
GSE178340_7_v_9_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.880938
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4355-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15803157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28431
PRKAR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11602
GTEX-SIU7-1126-SM-2XCDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04651
r9 portion of vagal motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12921
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971885
disopyramide-7276	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lm7	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.899
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A61014366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01938
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.834525
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.67162
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
LGALS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00813813
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23157
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4467679-12967_2015_546_MOESM3_ESM.csv--TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H64	GDSC Cell Line Gene Expression Profiles	1.0	1.61774
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24735
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976341
Bacterial degradosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K42385001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22559
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827585
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.05274
CD200	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058632
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3L7-01A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
933_BTNL9_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.5455
CLEC9A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549548
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25216
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K57748937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00289
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14277
BRD-K49666076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82862
BRD-K45563993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20924
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051818
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.84223
RL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24516
GTEX-PWO3-1026-SM-2I5F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31205
GFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11589
GTEX-RWS6-0626-SM-2XCAS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12476
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.1406
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05928
GTEX-X4XX-0926-SM-46MV7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23621
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3854
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.31748
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.663
DCP1A	Pathway Commons Protein-Protein Interactions	1.0	null
9602_UPF3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.724202
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19100834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67593
BRD-K20526256_HG-14-10-04_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ECHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01356
SSTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34162
BRD-K96295480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00804
Developmental dysplasia of the hip 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.431
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80036
BRD-K63614330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33259
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01502
BRD-K37764012_PF-3758309_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52881132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58176
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544283
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294766
ATM_knockdown_113_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.75698
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065673
COLO679	DepMap CRISPR Gene Dependency	1.0	2.43466
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K13888422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26955
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31335
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE178532_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051557
CL-34	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mantle zone of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10822
GSE175787_13_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
edrophonium chloride-1519	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233694
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
BRD-K03141963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15868
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
CD3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615417
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0077
A549_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161881
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.87982
ChIP_CTCF_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.51263
Kidney Chromophobe_KICH_TCGA-KN-8436-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH747	DepMap CRISPR Gene Dependency	1.0	3.27248
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97487
PMC4443289-molce-38-5-466-supplementary.pdf-8-LHX6_LHX6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84990603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48902
BRD-K99221119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65581
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05276
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52842
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.80121
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POYW-0826-SM-2XCEM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52089
RNPS1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H322M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44879
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.908922
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.03304
5548_NDUFAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.646487
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39236
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.9883
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CHLA57	DepMap CRISPR Gene Dependency	1.0	2.93001
(-)-MK-801-3081	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K79090631_CGP-60474_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58998
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21857
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K78337983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14433
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69872823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5931
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
laudanosine-2890	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03741
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52025
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44468
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S8-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05161
BRD-K02708799_GSK-1059615_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UMUC14	DepMap CRISPR Gene Dependency	1.0	3.39867
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01325
pronetalol-7322	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830403
Thymus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.12927
BRD-K50884475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02093
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28117
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
PYGB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574147
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0104
GTEX-X15G-0526-SM-3NMB7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9745
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9436
TRRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93347
ATF3-27146783-CHIP-SEQ-COLON-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K16479784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03121
PMC5687749-pone.0188272.s005.xlsx-Supplementary_Table_3-Supplementary_Table_3_Differentially_Expressed_Genes_in_Common_between_AFX_compared_to_both_Keratinocytes_and_Fibroblasts_FOXO4	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.527002
BRD-K03243737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30412
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
769P_KIDNEY	CCLE Cell Line Proteomics	1.0	3.92203
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT549	DepMap CRISPR Gene Dependency	1.0	2.60912
K562_Fedratinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218786
BRD-K34624391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76018
GSE169205_0_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
dorsolateral preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24069
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06914
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.836404
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053112
BRD-K99581286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25114
H3K36me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HC-11-RK51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327616
7500_RPS12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50089
TEK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12688
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TOPORS	Pathway Commons Protein-Protein Interactions	1.0	null
Set1C/COMPASS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.632
bed nucleus of stria terminalis, lateral amygdaloid division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63452
GSE246053_1_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.65
KMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89117
JHH-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EM2	DepMap CRISPR Gene Dependency	1.0	2.87618
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
GW body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.717
Shoot apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.978
KDM1A	ENCODE Transcription Factor Targets	1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-2626-SM-2I3F6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868949
GSE178714_6_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
UPF 648	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
HIVEP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606061
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46681
E2F4	ENCODE Transcription Factor Targets	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58248556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03067
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.634
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aliskiren	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
A549_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163343
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890958
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.79475
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CD300LG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00819687
Cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.008
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06302
Chromatin silencing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.894
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044953
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831471
BRD-K49875070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44987
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.576
BRD-K18402224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06085
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-371b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
3,5-Dichlorosalicylic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.5
BRD-K36208388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60948
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.588
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.55456
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33438
SREBP2-21459322-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03332
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285411
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.918398
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.827006
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
U2AF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.646
KYSE-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormal embryo morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Dentate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22387
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14137
KAT2B	ENCODE Transcription Factor Targets	1.0	null
CAMTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10454
ELMOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30636
BRD-K80923834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21291
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94775036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22424
BRD-K02535446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0485
BRD-K75207324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24473
GTEX-RU1J-0226-SM-2TF5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14668
ketanserin-3209	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE178340_5_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17015
BRD-K28247259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52451
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.16214
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K28874552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32604
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.895439
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34743
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41232
superficial stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13555
NF2	MSigDB Cancer Gene Co-expression Modules	1.0	null
PMC7958471-13046_2021_1835_MOESM8_ESM.xlsx-KMT2A-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Enterovirus 71_8Hour_None_GSE15323	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.1676
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08802
Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8135
GTEX-OXRL-2626-SM-2I3F1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868806
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PCWH syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
SARS-dORF6_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.22504
BRD-K56188108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71025
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.9342
BRD-K83190598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21161
AZIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576819
r6 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26112
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04725393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75225
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.911362
GSE126127_2_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
8594_SUPT16H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513765
ATPase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.924
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EDS1 disease-resistance complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.569
METTL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84647
UACC-812	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985343
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	1.28301
hsa-miR-4766-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78776
karpas707	HPA Cell Line Gene Expression Profiles	-1.0	-0.883165
GTEX-RN64-0626-SM-2TC5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09868
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38233
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4340-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A27693633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24584
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-373	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
Nonsense-Mediated Decay (NMD)	Reactome Pathways 2014	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K07484899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06028
BRD-K04367224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90939
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828023
BRD-K02719847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70055
CD-47-YL43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237934
mRNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.461
Nervous system development	Reactome Pathways 2024	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.945
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26803
BRD-K28017317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45324
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02671211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02506
BRD-K62504352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17944
BRD-K32636001_MLS-0437446.0001_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340079
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H5-01B-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
SPATA5L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05124
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19452
Venom apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.584
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.860123
Plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.585
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_7461_KO_SETD2_SRP125695	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.68729
Nonsense-Mediated Decay (NMD)	Reactome Pathways 2024	1.0	null
SARS-ddORF6_96Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.75935
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-8118-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD4_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8308
BRD-K90808566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03491
posteroventral (inferior) parietal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24277
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-2826-SM-4B66J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89055
BRD-K31851055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20187
PMC8945030__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S3-MECOM_down_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A26165232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.58107
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09055
MXRA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00686987
BRD-K23196166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2068
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41344
CFPAC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69701
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875158
Rectum adenocarcinoma_READ_TCGA-F5-6571-01A-12R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43966357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01891
APP	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Parasubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75291
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15280583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71177
BRD-K64591035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10901
Eukaryotic translation initiation factor 4F complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.441
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.74793
BRD-K93032100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40586
Prostate adenocarcinoma_PRAD_TCGA-EJ-8472-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BMPR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477284
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08271
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16268355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29206
BRD-K77272277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01439
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CG-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5561-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79402882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92375
binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-OXRP-0326-SM-33HBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953027
Polysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.176
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6215
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12404
K562_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217994
PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S13-Table_S13_MR_resluts_of_brain_pQTL_and_large-artery_atherosclerotic_stroke_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Nuclear pore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.54
UBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09696
amygdalo-striatal transition	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1613
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Small nuclear ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.692
GTEX-XOT4-0326-SM-4B66S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824517
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ADARB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055789
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.644
Cytoplasmic stress granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.749
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.712648
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.942472
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48462
BL5519 (PCNT)	NURSA Protein Complexes	1.0	null
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65526
ELOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61931
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
upf3b	GeneRIF Biological Term Annotations	1.0	null
Perturb_8300_KD_AUH_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.11664
liothyronine-4947	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72561299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12469
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04366109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58433
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941983
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02631
ALAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633441
GTEX-WRHU-0926-SM-4E3IG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65536
NCIH508	CCLE Cell Line Gene CNV Profiles	1.0	2.03421
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07612
chr13_114301189_C_T_b38	GTEx eQTL 2025	1.0	2.3861
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45341
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28656
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13207
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10868
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997981
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
Brain Lower Grade Glioma_LGG_TCGA-TM-A84T-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Flocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38629
SLC66A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13939
GTEX-QDVJ-0226-SM-2I5FV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987574
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54093
r8 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4919
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03517
Anaplastic thyroid cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.149
hupf3b	GeneRIF Biological Term Annotations	1.0	null
BRD-K37780492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13774
Proteinuria	CTD Gene-Disease Associations	1.0	1.32251
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1573	DepMap CRISPR Gene Dependency	1.0	4.2836
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32282076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83657
MCF7_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139631
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.887932
Nuclear speck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.169
WARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478982
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NSC43673	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78859
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.779765
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02393
SCS214	DepMap CRISPR Gene Dependency	1.0	2.76092
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3444
Duchenne muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.675
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4261
IGFBP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00610203
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94284
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.73441
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.91874
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.364
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-374c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
rolipram-6449	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7156-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1395	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46196
substantia nigra, reticular part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.824411
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAOK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497983
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-188-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.25399
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041948
Kidney Chromophobe_KICH_TCGA-KM-8439-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOLP-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41845
CTCF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41427
K562_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210763
H3K36me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.00689
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7806
Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE9857	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.54944
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975323
ANXA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663892
Sarcoma_SARC_TCGA-DX-A7EO-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30594227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40759
positive regulation of translation	GO Biological Process Annotations 2023	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28833
PMC6412103-mmc1.docx-5-M00695_ETF_P_8_350E-5_N_428_31_5_3_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBEW-0126-SM-4AT66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08502
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.883653
BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K61052964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03698
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MN-60	GDSC Cell Line Gene Expression Profiles	1.0	2.01852
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of gene expression	GO Biological Process Annotations 2025	1.0	null
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
496100615_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28155
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.45547
periventricular stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03093
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23476
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842959
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Scleroderma_Fibroblast_GSE1724	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.95263
BRD-K56428170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87531
BRD-K74660272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.86733
heptaminol-6015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27242
Nuclear dicing body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.019
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36236
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35682
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.75584
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
Flocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11928
mantle zone of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03255
UBE2Z	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12017
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01428
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
K562_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181205
BRD-K70584304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15178
MXI1	ENCODE Transcription Factor Targets	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYK_knockdown_191_GSE54065	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.49378
BRD-K07350528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9057
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.535325
U6 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.929
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2638
TOMM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710392
BRD-K10481024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59429
GATA1_G1E-ER4_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123958,GSE123959_0_v_1_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02708799_GSK-1059615_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
CALU3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78312
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84107
BRD-K15607890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69726
GSK3B	Hub Proteins Protein-Protein Interactions	1.0	null
Retrosplenial area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34831
Parasolitary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9594
BRD-K69087429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12132
TMEM234	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94809
MAPK1_knockdown_112_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.12359
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3324-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521972
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66653
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42078
Brain Lower Grade Glioma_LGG_TCGA-DB-A75M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-15-VR68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25029
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.775672
PLEKHF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02778
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RENT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.605
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
Sporophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37506
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9635
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.612203
SETDB1	ENCODE Transcription Factor Targets	1.0	null
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
etiocholanolone-6060	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
embryonic lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
Hodgkin's lymphoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
xamoterol-3401	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11691
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54979104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87042
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ready	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-302c	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ursodeoxycholic acid-7243	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
(S)-Selisistat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-13q34_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18190982_COT-10b_PL21_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHLA266	DepMap CRISPR Gene Dependency	1.0	3.83153
BRD-K56086519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11271
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52379
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
P-body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.379
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51T-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84800135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61292
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79325
BRD-K02371763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5591
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248587
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03009
BRD-K60662039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08692
GJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.927807
K562_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157479
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fruit capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.21
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	1.41581
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93601851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78265
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.03695
PBX3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60943
4108_IMP4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.518185
intermediate stratum of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07182
BRD-K39435284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08794
chr13_114294290_A_G_b38	GTEx eQTL 2025	1.0	2.12223
CHD4	ENCODE Transcription Factor Targets	1.0	null
FGF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613539
amphotericin B-6303	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NFK9-0726-SM-2HMJW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19582
lymphnode_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.879207
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
SARS-BatSRBD_0Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.92501
BRD-K97977764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58314
triggers	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K85615919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42386
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274738
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.849923
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.615019
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902515
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Developmental and epileptic encephalopathy 65	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.916
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32182
hsa-miR-4520a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K62852603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09389
SKMEL2	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.10256
BRD-K87602457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25509
GTEX-R55E-0826-SM-2TC5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03853
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.78645
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914113
A549_Ofloxacin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133929
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
A101D_SKIN	CCLE Cell Line Proteomics	1.0	2.11813
Eukaryotic translation initiation factor 2B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.012
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
UBE2N	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2343
intermediate part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18905
Lung adenocarcinoma_LUAD_TCGA-J2-A4AE-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A22089150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09135
6-azathymine-2827	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173816
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72580121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09592
ALKBH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666677
BRD-K86925685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23125
BRD-A21814529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10131
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TTF2	ChEA Transcription Factor Targets	1.0	null
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95282
TRAPP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.568
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
20220088-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
exon-exon junction complex	GO Cellular Component Annotations 2015	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.44645
BRD-K92524823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73806
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.60267
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PH-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37019305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46367
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A00680357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59635
GSE199541_2_v_4_mbd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876865
MAX	ENCODE Transcription Factor Targets	1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF770	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53313
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K36me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16573
KCNQ5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00748414
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.397498
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10032
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
amikacin-5314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-580	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70889
Acute Myeloid Leukemia_LAML_TCGA-AB-2913-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14124956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33067
dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.224558
hsa-miR-520a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
SNU761	DepMap CRISPR Gene Dependency	1.0	2.45814
BRD-K04443775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01576
Sepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.766
Cotyledon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.129
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KMH-2	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.24687
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59954
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49512
JHOS2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.4618
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.84581
positive regulation of translation	GO Biological Process Annotations 2015	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.994655
embryonic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.144704
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7149-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSNK1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533387
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1403
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
cefaclor-4967	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-SI-A71O-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JAK2_activemutant_72_GSE21842	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.78472
carmustine-6914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178528
NCIH2009	CCLE Cell Line Gene CNV Profiles	1.0	1.85065
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UJMC-1926-SM-3GADS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88124
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K09468701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73211
BRD-K51697562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48766
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15579
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983872
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K33967062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33681
Retrosplenial area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90301
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
K562_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156864
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15746
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98374711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51497
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.845233
BL9430 (C7orf20)	NURSA Protein Complexes	1.0	null
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4617-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
BCL7C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639334
Inflammatory myofibroblastic tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-342-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
OVMIU	DepMap CRISPR Gene Dependency	1.0	2.21235
WA-53-FZ40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333514
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.6473
sulfadimidine-3940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88150784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05996
NDUFV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627105
MONOMAC6	CCLE Cell Line Gene Expression Profiles	1.0	2.01938
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12611
Prp19 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.314
LC1F	CCLE Cell Line Gene Expression Profiles	-1.0	-2.10707
regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
BRD-K73635724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06995
Perichromatin fibrils	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.754
GSE153189_1_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-520c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113