association	dataset	threshold value	standardized value
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7987
FSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10488
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0168
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5625
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572523
PMC9160255-41467_2022_30710_MOESM6_ESM.xlsx-DHT_AR_ASO_super_enhancers-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TCF3_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
2796_EXOSC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528761
ZNF92	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35134
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7129
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9716
SETBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61042
496100499_PCx_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06773
GSE86021_0_v_1_crenolanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12644
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.44701
IFI27L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55116
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.580209
PMC9160255-41467_2022_30710_MOESM6_ESM.xlsx-AR_ASO_super_enhancers-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CIITA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37085
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05609
TSPOAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4647
PMC6718408-41467_2019_11884_MOESM6_ESM.xlsx-TAD_genes_ST-EPN-RELA-Unnamed_4_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
10348_ZNF423_ENST00000262383.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.53434
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7313
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4523944-DataSheet1.PDF-33-MBNL2_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5006
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.4121
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DTWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72602
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
2795_EXOSC8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.6089
HELT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53669
MEX3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29703
6794_PRPF38A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51329
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.788469
METTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09107
ARHGAP27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63276
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2667
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8723
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.52117
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6237
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100625_FWM_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17901
RPP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41146
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1509
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RALB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06598
GSE169205_0_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8126_SLU7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.920546
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.629517
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
6026_PABPN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544752
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRUNE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14041
UBXN2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03393
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
TRMT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03023
PMC3680531-cc-12-1510-s01.pdf-24-SP100_SP100	Rummagene Transcription Factor Associations 2026	1.0	null
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.637186
PMC9160255-41467_2022_30710_MOESM6_ESM.xlsx-DHT_AR_ASO_super_enhancers-ENSEMBL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HEPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12516
UQCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02149
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19561
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4079
L1TD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35797
1878_CRNKL1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32801
HINT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35932
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9345
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1627
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2257
DHFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99564
ZNF512	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23866
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1009
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7642
GSE144347_1_v_0_crnkl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10795826-jciinsight-8-170518-s128.xlsx-Fig_5B-Gene_Regulated_by_VDR_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
GEMIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25785
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5103
GSE128076_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1998
IQCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13121
MICALL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59158
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4387
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRIM41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13705
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4208
PLBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13313
PPP2R3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03797
GSE224439_1_v_3_adagrasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98812
FICD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47071
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6109
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.6045
MUSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62247
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHURC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0888
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
GPR180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64273
PMC9314667-Table_1.xlsx-Regulons-SOX11_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1701
H1-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06185
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4937
RPS19BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2791_EXOSC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.81102
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570746
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.087
RC3H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16649
PHLDA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04144
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5425
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
7206_RCL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513679
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.17944
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.5425
SLC7A6OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03265
TMED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48455
GNL3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60619
4994_METTL16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503597
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
UHRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48481
GTEx Colon 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-4.91317
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
C4orf36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40588
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S8-DUX4_SpecDMCs-Unnamed_3_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32582
PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.800876
SRP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12951
PMC9160255-41467_2022_30710_MOESM6_ESM.xlsx-AR_ASO_super_enhancers-ENSEMBL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9306206-12915_2022_1367_MOESM8_ESM.xlsx-Table_S9_-_JIP-Gene_SMAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5841
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7996
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2778
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.7279
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.194
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.1562
1878_CRNKL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543741
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9218
CCDC74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16153
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.53037
GSE160817_7_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2068
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2626
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135350_3_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7827
MFSD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60374
CLUH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05165
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.85456
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6592
HSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28655
SELENOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04541
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.548523
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09032
4217_ISY1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505235
mitochondrial respiratory chain complex III assembly	GO Biological Process Annotations 2025	1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4329
CTSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3587
ACSM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7901
WDR77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13697
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0773
496100411_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18708
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEP76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01987
ARFGEF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45738
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7587
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7839
PER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14988
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.64962
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.806
ZNF214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13773
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07462
GSE175787_13_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACTL6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24327
DERL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19376
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
2791_EXOSC4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50955
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0841
GTEx Stomach 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-6.89653
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.4191
SNRPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42464
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4051124-1471-2164-15-256-S15.XLSX-WES_IPD-RBCK1_1-Target_RBCK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
FGFBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03912
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12532594-41380_2025_3119_MOESM1_ESM.pdf-124-ST18_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
MAP3K11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1722
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1792
RCOR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05292
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08191
PLSCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15499
HK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47072
LONP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28104
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.62202
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7004
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7871
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BIRC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.406
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.923934
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505247
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2789_EXOSC2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.773757
COMTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95496
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30401
496100321_HIP_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.47194
GSE149760_0_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206516,GSE206518_1_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6742
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8456
496100589_PCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.68822
699_ATR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528241
ZNF429	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17722
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0172
RAB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03646
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-6.49461
CTU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25136
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2842
GSE86021_1_v_3_crenolanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34404
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRMT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08294
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.30834
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11872
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.800719
PMC9691391-7945884.f3.pdf-82-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
PIP5KL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39308
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537382
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NR2C2_NR2C2	Rummagene Transcription Factor Associations 2026	1.0	null
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1293
ZNF510	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02688
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9482
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1207
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6740_PREB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10325
MYL12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64777
BORA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18876
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
C14orf119	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13173
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	2.31019
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151090_0_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.89
PTRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19992
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03249
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.556853
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
FOSB::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1659
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100378_TCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27223
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ESPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49004
LAMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30794
FASTKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16461
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DCTN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02396
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.8576
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2078
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7956
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.52728
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5554
POLR2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04613
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8808
REV3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16312
CALHM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13699
KIF21A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23247
PHF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0082
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4901
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6934
496100609_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02515
WDR26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41993
ZNF528	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6033
PRKX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11257
PCDHB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25454
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7102
ARFGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09785
CYP2R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94572
MMP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0546
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1661
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1461
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01025
CHID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34205
respiratory chain complex III assembly	GO Biological Process Annotations 2025	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_pos_targets-ID_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
LSM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3247
HMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0654
G57321FI	GlyGen Glycosylated Proteins	1.0	null
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6866_PSMD12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0141
TECR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25129
PMC7801680-41598_2020_79740_MOESM9_ESM.xlsx-STAT3_target_genes_in_N1-GOPC_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195568_1_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6463
GSE133516_0_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DQX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15695
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_1_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSK3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3832
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0009
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.854714
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F4_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
UQCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27487
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8374
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92937
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
2790_EXOSC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.683739
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32841
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2516
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0768
CASP8AP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02872
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF614	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87548
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
mitochondrial respiratory chain complex assembly	GO Biological Process Annotations 2025	1.0	null
IL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04255
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1705
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.418
COX5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05632
NPIPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14313
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.6932
CAMK2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10243
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
IGF2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66289
FBXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13613
999_C16ORF91_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.629016
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.976289
MAP3K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22205
VASH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02788
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.7161
ADGRG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15877
GSE165548_2_v_8_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.802349
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.47355
KRT18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22966
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
8853_TFIP11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00866
PPP3CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31254
KPTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11711
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1683
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9367
BCL2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11503
PMC3680531-cc-12-1510-s02.pdf-27-SP100_SP100	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_8-ILL1_T_Cells_FOXP3_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16349
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_pos_targets-Gene_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9549
ERI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14259
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9831
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CASP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3232
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25138
FLOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11867
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.561279
NDUFB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18622
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
ICE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11335
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173201_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.3766