association	dataset	threshold value	standardized value
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.905023
REC1	CCLE Cell Line Gene CNV Profiles	1.0	1.72767
HT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78493
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53906
EW7	DepMap CRISPR Gene Dependency	1.0	2.17265
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14664
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5254
RT112	CCLE Cell Line Gene CNV Profiles	1.0	1.78257
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9047
Ubiquitin specific protease domain	InterPro Predicted Protein Domain Annotations	1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.977474
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50322
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.977474
UACC893	DepMap CRISPR Gene Dependency	1.0	2.51329
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.1517
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9122
OCILY18	DepMap CRISPR Gene Dependency	1.0	2.11329
regulation of cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
HS729	CCLE Cell Line Gene CNV Profiles	1.0	1.62118
proteasomal protein catabolic process	GO Biological Process Annotations 2015	1.0	null
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6735
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828822
cerebral cortex	HPA Tissue Protein Expression Profiles	-1.0	-0.903885
HS746T	DepMap CRISPR Gene Dependency	1.0	2.68953
regulation of programmed cell death	GO Biological Process Annotations 2025	1.0	null
cysteine-type peptidase activity	GO Molecular Function Annotations 2015	1.0	null
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
regulation of proteolysis	GO Biological Process Annotations 2015	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33498
cysteine-type endopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
SH10TC	CCLE Cell Line Gene CNV Profiles	-1.0	-2.1676
Hep-G2/C3A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.694
496100421_PCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14314
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7491
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922577
SNU620	DepMap CRISPR Gene Dependency	1.0	3.60158
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.553
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5833
liver	HPA Tissue Protein Expression Profiles	-1.0	-1.44517
A375SKINCJ1	DepMap CRISPR Gene Dependency	1.0	2.07535
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0157
HS695T	CCLE Cell Line Gene CNV Profiles	1.0	1.73114
KNS62	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86965
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1387
LS1034	DepMap CRISPR Gene Dependency	1.0	2.95656
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.212
HCC2218	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58846
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983025
TOV21G	CCLE Cell Line Gene CNV Profiles	1.0	2.3175
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.32926
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866072
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.17725
guanyl-nucleotide exchange factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.152
SET2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47126
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893239
cellular macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0647
SNU16	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49099
endoplasmic reticulum	GO Cellular Component Annotations 2015	1.0	null
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31082
regulation of proteolysis involved in cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
CORL23	DepMap CRISPR Gene Dependency	1.0	2.64296
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9303
TGBC52TKB	DepMap CRISPR Gene Dependency	1.0	3.36336
MERO83	DepMap CRISPR Gene Dependency	1.0	2.77499
CAL78	DepMap CRISPR Gene Dependency	1.0	2.53702
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ONDA7	DepMap CRISPR Gene Dependency	1.0	3.08693
Deubiquitination	Reactome Pathways 2024	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922577
LN443	DepMap CRISPR Gene Dependency	1.0	2.06805
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6875
Immune system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6663
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9071
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.9674
catabolic process	GO Biological Process Annotations 2015	1.0	null
NCIH2291	DepMap CRISPR Gene Dependency	1.0	2.10839
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70088
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828822
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.3271
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4518
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828501
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
UPCISCC026	DepMap CRISPR Gene Dependency	1.0	3.20499
epididymis	HPA Tissue Protein Expression Profiles	1.0	1.32926
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3737
RCHACV	DepMap CRISPR Gene Dependency	1.0	2.45188
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00171
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-1.44517
MM386	DepMap CRISPR Gene Dependency	1.0	2.23655
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54068
HCC1806	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95376
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983025
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42358
organelle	GO Cellular Component Annotations 2015	1.0	null
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03948
CAOV4	DepMap CRISPR Gene Dependency	1.0	3.09151
RT11284	CCLE Cell Line Gene CNV Profiles	1.0	1.34116
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5457
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983025
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.976613
LN428	DepMap CRISPR Gene Dependency	1.0	2.88131
intracellular part	GO Cellular Component Annotations 2015	1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.938616
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8784
REH	CCLE Cell Line Gene CNV Profiles	1.0	1.41854
Lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PANC0327	DepMap CRISPR Gene Dependency	1.0	2.07782
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3714
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.228
GP5D	DepMap CRISPR Gene Dependency	1.0	3.67605
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	2.07461
KYSE510	DepMap CRISPR Gene Dependency	1.0	2.25531
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-1.44517
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52074
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
ICC4	DepMap CRISPR Gene Dependency	1.0	2.27377
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0718
proteolysis	GO Biological Process Annotations 2015	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3206
MDA-MB-330	COSMIC Cell Line Gene CNV Profiles	-1.0	-5.12655
KIJK	DepMap CRISPR Gene Dependency	1.0	3.62036
rectum	HPA Tissue Protein Expression Profiles	1.0	1.32926
NCIH747	DepMap CRISPR Gene Dependency	1.0	2.4569
SW1710	CCLE Cell Line Gene CNV Profiles	1.0	2.49101
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828822
KP3	CCLE Cell Line Gene CNV Profiles	1.0	1.66062
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
496100672_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41363
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
AMO1	DepMap CRISPR Gene Dependency	1.0	2.32761
HLF	CCLE Cell Line Gene CNV Profiles	1.0	1.44563
nucleus	GO Cellular Component Annotations 2015	1.0	null
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.44517
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.02719
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.79416
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.00426
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54068
VMRCLCD	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51354
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-1.44517
cysteine-type peptidase activity	GO Molecular Function Annotations 2025	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.44517
YH13	DepMap CRISPR Gene Dependency	1.0	2.38717
ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
NCIH1373	CCLE Cell Line Gene CNV Profiles	1.0	1.42321
496100350_FWM_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20267
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19603
GSU	DepMap CRISPR Gene Dependency	1.0	2.17205
OCIAML2	DepMap CRISPR Gene Dependency	1.0	3.01964
NCIH1341	CCLE Cell Line Gene CNV Profiles	1.0	1.45256
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3978
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14664
MYLA	DepMap CRISPR Gene Dependency	1.0	2.77198
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
THP1	DepMap CRISPR Gene Dependency	1.0	2.71196
ES5	DepMap CRISPR Gene Dependency	1.0	2.96466
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6093
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Hyaluronan/mRNA-binding protein	InterPro Predicted Protein Domain Annotations	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04445
KELLY	DepMap CRISPR Gene Dependency	1.0	2.44115
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922577
JHUEM7	DepMap CRISPR Gene Dependency	1.0	2.58917
NCIH1436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55493
protein modification by small protein removal	GO Biological Process Annotations 2015	1.0	null
Bone marrow stromal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.17
biological regulation	GO Biological Process Annotations 2015	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.8321
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SKMG1	DepMap CRISPR Gene Dependency	1.0	2.2196
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Metabolism of proteins	Reactome Pathways 2024	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
ECC12	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05819
Ubiquitin specific protease, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04445
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
protein deubiquitination	GO Biological Process Annotations 2015	1.0	null
UW228	DepMap CRISPR Gene Dependency	1.0	2.20967
peptidase activity	GO Molecular Function Annotations 2015	1.0	null
protein modification process	GO Biological Process Annotations 2015	1.0	null
496100292_PCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22288
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2179
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30674
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8459
496100644_HIP_probable Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.81802
YD15	DepMap CRISPR Gene Dependency	1.0	2.31174
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889738
SNU638	DepMap CRISPR Gene Dependency	1.0	3.1089
proteasome-mediated ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7546
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19603
UHO1	DepMap CRISPR Gene Dependency	1.0	3.2522
Post-translational protein modification	Reactome Pathways 2024	1.0	null
L1236	DepMap CRISPR Gene Dependency	1.0	2.83584
496100279_TCx_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29837
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08795
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3197
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8572
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8344
RERFLCAD1	CCLE Cell Line Gene CNV Profiles	1.0	2.04563
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23641
PATU8988S	DepMap CRISPR Gene Dependency	1.0	3.3986
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2474
regulation of cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30674
cervix, uterine	HPA Tissue Protein Expression Profiles	1.0	0.736095
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.455
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
SJSA1	DepMap CRISPR Gene Dependency	1.0	2.14259
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8141
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.976613
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983025
PMC9727756-media-2.pdf-196-HOXC6_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
ubiquitinyl hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1209
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889738
biological_process	GO Biological Process Annotations 2015	1.0	null
modification-dependent macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72314
NB69	DepMap CRISPR Gene Dependency	1.0	3.51174
HUH7	CCLE Cell Line Gene CNV Profiles	1.0	1.3436
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00171
HCC1395	CCLE Cell Line Gene CNV Profiles	-1.0	-2.68669
COLO792	DepMap CRISPR Gene Dependency	1.0	2.05077
U118MG	DepMap CRISPR Gene Dependency	1.0	2.40745
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03948
JK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37771
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
TGBC11TKB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66854
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0728
fallopian tube	HPA Tissue Protein Expression Profiles	1.0	1.32926
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4652
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HEP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09303
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03948
UMUC1	CCLE Cell Line Gene CNV Profiles	1.0	2.16729
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889738
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1525
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
DANG	DepMap CRISPR Gene Dependency	1.0	2.01257
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HEP3B217	CCLE Cell Line Gene CNV Profiles	1.0	1.40745
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34595
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8696
TOV21G	DepMap CRISPR Gene Dependency	1.0	3.52988
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.111
cysteine-type deubiquitinase activity	GO Molecular Function Annotations 2025	1.0	null
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7475
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964955
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.00958
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65384
ubiquitin-specific protease activity	GO Molecular Function Annotations 2015	1.0	null
HS852T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48869
DKMG	DepMap CRISPR Gene Dependency	1.0	2.14398
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828822
SNU1	DepMap CRISPR Gene Dependency	1.0	3.20727
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42205
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983025
GSS	CCLE Cell Line Gene CNV Profiles	-1.0	-2.8155
Late endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.12
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.79249
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1447
cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.66825
SKNMC	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46058
PEO4	DepMap CRISPR Gene Dependency	1.0	2.66433
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.4793
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8455
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889738
HS-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.583
cellular_component	GO Cellular Component Annotations 2015	1.0	null
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4908
macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
496100579_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50916
HPAFII	DepMap CRISPR Gene Dependency	1.0	2.28039
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2936
786-O	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.829994
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54844
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.372
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.82084
496100366_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23177
SKBR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65369
NCIH358	CCLE Cell Line Gene CNV Profiles	1.0	1.33632
HS294T	DepMap CRISPR Gene Dependency	1.0	2.35842
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SUDHL8	DepMap CRISPR Gene Dependency	1.0	2.47166
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34595
deubiquitinase activity	GO Molecular Function Annotations 2025	1.0	null
NB10	DepMap CRISPR Gene Dependency	1.0	3.03247
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.061
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.941
stomach	HPA Tissue Protein Expression Profiles	1.0	0.736095
496100643_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.60725
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MDST8	DepMap CRISPR Gene Dependency	1.0	2.74616
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	187.455
SNU5	DepMap CRISPR Gene Dependency	1.0	3.16412
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9042
NB17	DepMap CRISPR Gene Dependency	1.0	2.87593
regulation of catabolic process	GO Biological Process Annotations 2015	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38076
SW1990	DepMap CRISPR Gene Dependency	1.0	2.19328
Ub-specific processing proteases	Reactome Pathways 2024	1.0	null
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38002
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.6208
BE2M17	DepMap CRISPR Gene Dependency	1.0	3.02858
regulation of proteasomal protein catabolic process	GO Biological Process Annotations 2015	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14434
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1248
Prostate gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81586
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6825
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5177
SNU410	DepMap CRISPR Gene Dependency	1.0	3.25308
HLFA	CCLE Cell Line Gene CNV Profiles	1.0	1.70338
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0833
Cell wall-bounded periplasmic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.791
RAJI	DepMap CRISPR Gene Dependency	1.0	2.8871
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.508
regulation of apoptotic process	GO Biological Process Annotations 2025	1.0	null
Peptidase C19, ubiquitin carboxyl-terminal hydrolase	InterPro Predicted Protein Domain Annotations	1.0	null
COLO824	DepMap CRISPR Gene Dependency	1.0	2.97068
HOS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65179
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.9221
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.492
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54773
protein catabolic process	GO Biological Process Annotations 2015	1.0	null
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.29815
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.8763
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922577
KE39	DepMap CRISPR Gene Dependency	1.0	3.34484
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60635
NCIH1693	CCLE Cell Line Gene CNV Profiles	1.0	1.69079
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9385
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828822
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.37813
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18444
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8978
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4245
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21283
NCIH1651	CCLE Cell Line Gene CNV Profiles	1.0	1.33471
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6475
PATU8902	DepMap CRISPR Gene Dependency	1.0	3.59235
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
U343	CCLE Cell Line Gene CNV Profiles	1.0	1.70306
496100597_HIP_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44421
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1992
cellular process	GO Biological Process Annotations 2015	1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38076
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5213
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28598
496100400_PCx_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05093
NB4	CCLE Cell Line Gene CNV Profiles	1.0	1.44418
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9811
Ragulator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.154
SKMEL1	CCLE Cell Line Gene CNV Profiles	1.0	3.27631
HSSCH2	DepMap CRISPR Gene Dependency	1.0	3.09001
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.768
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02444
PMC12719073-mmc1.pdf-14-MYSM1_MYSM1	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
RVH421SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.15513
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.828822
MHHES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77702
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8321
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.46108
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
urinary bladder	HPA Tissue Protein Expression Profiles	1.0	1.32926
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09303
regulation of protein catabolic process	GO Biological Process Annotations 2015	1.0	null
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
496100285_TCx_probable Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.30185
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69525
TE11	DepMap CRISPR Gene Dependency	1.0	3.30726
496100546_TCx_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41725
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2936
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50322
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922577
HEC251	DepMap CRISPR Gene Dependency	1.0	2.95486
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1248
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ubiquitin-like protein-specific protease activity	GO Molecular Function Annotations 2015	1.0	null
KPNYS	DepMap CRISPR Gene Dependency	1.0	3.03264
DBTRG05MG	DepMap CRISPR Gene Dependency	1.0	3.58134
modification-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
KELLY	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38038
OCILY19	DepMap CRISPR Gene Dependency	1.0	3.36116
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.047
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866072
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2419
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.733
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.39131
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3567
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52074
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866072
peptidase activity, acting on l-amino acid peptides	GO Molecular Function Annotations 2015	1.0	null
K029AX	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3543
endopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0647
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8423
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5812
JHU029	DepMap CRISPR Gene Dependency	1.0	2.69297
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5546
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23641
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6723
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922577
HCC2279	CCLE Cell Line Gene CNV Profiles	1.0	1.55036
NCIH157DM	DepMap CRISPR Gene Dependency	1.0	2.06188
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.2114
SNU601	CCLE Cell Line Gene CNV Profiles	-1.0	-2.26056
proteolysis involved in cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00171
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14515
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.905023
PGA1	DepMap CRISPR Gene Dependency	1.0	2.30671
OUMS23	DepMap CRISPR Gene Dependency	1.0	2.95795
nucleus	GO Cellular Component Annotations 2025	1.0	null
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0647
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09303
prostate	HPA Tissue Protein Expression Profiles	1.0	1.32926
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9364