association dataset threshold value standardized value Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.119 IKBKG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70684 A-Vietnam-1203_CIP048_RG3-2004(H5N1)_7Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.38887 regulation of protein metabolic process GO Biological Process Annotations 2015 1.0 null REST ChEA Transcription Factor Targets 1.0 null PIP4K2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.555 MEL270 DepMap CRISPR Gene Dependency 1.0 8.33191 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 SCARF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13478 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31329 Varicose veins DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.321 directly GeneRIF Biological Term Annotations 1.0 null Stomach disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.058 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68A-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null IGR-37 COSMIC Cell Line Gene Mutation Profiles 1.0 null IST-SL2 COSMIC Cell Line Gene Mutation Profiles 1.0 null primary metabolic process GO Biological Process Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04157 DNAJC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20519 HAND2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39704 ZFYVE26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.452 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11242 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.56193 Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.13 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.947339 RGS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.97119 Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCNX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41109 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.29265 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF519 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92837 HSFY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17109 IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.94305 Hypogonadotropic hypogonadism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 NUP58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07763 PIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40797 Brain Lower Grade Glioma_LGG_TCGA-FG-5965-01B-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83248 NCIH28 CCLE Cell Line Gene CNV Profiles 1.0 1.60249 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.88806 FAM110A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85716 orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.982452 ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.987166 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMTC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07501 RPS4Y1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40822 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0006 GSE200673,GSE200691_1_v_4_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ATP6V0C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24896 Pelvic varices DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.508 HLCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92098 ES-E14 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.596 SPIN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91915 increase GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A719-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COQ10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01904 RARRES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8231 Perturb_13274_KO_Zbtb24_SRP198760 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -18.0757 BRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08346 DBH_KO_GDS4324_362_mouse_Embryonic heart E10.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061693 SOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13963 GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.913645 WDHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74242 mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070723 CDK6 Pathway Commons Protein-Protein Interactions 1.0 null RIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64541 SAP18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6787 JHOS-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.32 GNB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93607 Nucleoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.964159 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XO-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZIM3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 67.4741 Obstructive Azoospermia DisGeNET Gene-Disease Associations 1.0 null dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.995942 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054031 GSE261563_5_v_1_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.867832 TEX45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14495 ESS1 CCLE Cell Line Gene Expression Profiles -1.0 -1.56262 Hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.093 SUM52PE DepMap CRISPR Gene Dependency 1.0 4.05838 primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36736 Cauda epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.011 Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF550 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28461 RHEBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35035 KIAA0232 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90482 RCOR1 ChEA Transcription Factor Targets 1.0 null GSE199255,GSE199356_6_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOXH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3954 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MTMR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79309 mammarygland.lact. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46785 FOXP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27859 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04977 Lung non-small cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.191 MRPS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06378 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.7 HS940T CCLE Cell Line Gene Expression Profiles -1.0 -1.69823 REST-19997604-NEURONS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CCNYL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61697 OVMIU COSMIC Cell Line Gene Mutation Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NY-05A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.43069 DLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86544 CNNM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19852 Breast Cancer_Mammary Gland Tissue_GSE3744 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.34388 Lung adenocarcinoma_LUAD_TCGA-55-7573-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHRD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84434 POU2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.0452 inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.58782 CCT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42327 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell cycle G1/S phase transition GO Biological Process Annotations 2023 1.0 null TEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49707 reproduction GAD High Level Gene-Disease Associations 1.0 0.305726 TBPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94226 SP110 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37212 decreased locomotor activity IMPC Knockout Mouse Phenotypes 1.0 null TIMP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45018 PDIA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4079 ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 71.0544 KLK10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77914 SNU81 DepMap CRISPR Gene Dependency 1.0 5.15453 hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.911878 Brain Lower Grade Glioma_LGG_TCGA-HT-7689-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.5876 infection GAD High Level Gene-Disease Associations 1.0 0.293278 Brain Lower Grade Glioma_LGG_TCGA-HT-7609-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FLNA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77218 ADPRH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63399 PITX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4088 organic substance catabolic process GO Biological Process Annotations 2015 1.0 null ANAPC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78599 USP45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59588 Prostate adenocarcinoma_PRAD_TCGA-VN-A88L-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1754 FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.037 TLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65833 FAM50A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84378 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043378 Hernia, Inguinal HuGE Navigator Gene-Phenotype Associations 1.0 null JUN-21703547-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HYOU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76707 SYT12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97421 H3C14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50218 AR Pathway Commons Protein-Protein Interactions 1.0 null PKBalpha_KO_GDS1784_194_mouse_Embryonic fibroblasts (MEFs) - 2h GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Proteasome accessory complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.179 USPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86245 RAB21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83252 PFKFB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61427 protein catabolic process GO Biological Process Annotations 2015 1.0 null FOXO1::ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3183 ZNF558 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 166.29 Infertility, Male HuGE Navigator Gene-Phenotype Associations 1.0 null Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.133 HCC1937 DepMap CRISPR Gene Dependency 1.0 2.8229 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.49009 HSPA8 Pathway Commons Protein-Protein Interactions 1.0 null ZC3H12D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61274 Site of DNA damage COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.275 cysteine-type peptidase activity GO Molecular Function Annotations 2025 1.0 null GSE139455_2_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.102 DAZAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89667 Central nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.3 piP-body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.703 thyroid GTEx Tissue Gene Expression Profiles 1.0 1.04797 CSKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52496 HTT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03549 PATZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60777 Prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.503 DUSP22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79056 suggested GeneRIF Biological Term Annotations 1.0 null Azoospermia HuGE Navigator Gene-Phenotype Associations 1.0 null LRIG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84844 FOXJ2::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0145 regulation of protein catabolic process GO Biological Process Annotations 2015 1.0 null 496100381_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.15569 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.838416 LARGE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92441 Site of double-strand break COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.304 cellular metabolic process GO Biological Process Annotations 2015 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX Rummagene Transcription Factor Associations 2026 1.0 null SUIT2 DepMap CRISPR Gene Dependency 1.0 2.07018 IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9911 RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TLNRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28686 ATXN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87128 ZMYND11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36324 MICAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76119 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Interstitial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.452 SEC61A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63642 ZC3H4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50421 GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null OTUD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14525 Darinaparsin_NCI-H661 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.013188 NCIH661 CCLE Cell Line Gene Expression Profiles 1.0 1.77623 ERF::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7269 mRNA_GATA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null regulation of proteasomal protein catabolic process GO Biological Process Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-4R-AA8I-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null contributing GeneRIF Biological Term Annotations 1.0 null Perturb_4983_Mut_Tet2_SRP111192 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.3741 Cul3-RING ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.004 GSE153757,GSE153758_1_v_3_ftsj1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ISYNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53232 METTL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.162 LOVO COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC95 CCLE Cell Line Gene Expression Profiles 1.0 1.47601 F36P CCLE Cell Line Gene Expression Profiles 1.0 1.66308 LNCaP-AI cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.719 Disorder of sexual development DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.335 metabolic GAD High Level Gene-Disease Associations 1.0 0.293278 Mesothelioma_MESO_TCGA-LK-A4O5-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IK-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Syndrome HuGE Navigator Gene-Phenotype Associations 1.0 null foci GeneRIF Biological Term Annotations 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null BATF::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1473 DLGAP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16319 NCI-H1944 COSMIC Cell Line Gene Mutation Profiles 1.0 null IZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23454 cysteine-type deubiquitinase activity GO Molecular Function Annotations 2025 1.0 null PCNA Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A76R-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5526 ATP5F1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88918 SGSM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65701 JHOS4 CCLE Cell Line Gene CNV Profiles -1.0 -1.51875 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.14445 Seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.833 RBFOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79902 HSC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null GCT CCLE Cell Line Gene Expression Profiles 1.0 2.65491 ACTG1 Pathway Commons Protein-Protein Interactions 1.0 null abnormal seminiferous tubule morphology MGI Mouse Phenotype Associations 2023 1.0 null GSE149124,GSE149128_3_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNU626 DepMap CRISPR Gene Dependency 1.0 2.65612 APP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63123 HT1080 CCLE Cell Line Gene Expression Profiles 1.0 3.40792 REST-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 C20orf96 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51809 MYCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95495 Lung adenocarcinoma_LUAD_TCGA-97-7937-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06917 GSE153443_1_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null IRF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9973 SLC35A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08087 LNCaP-C4-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.611 SPI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12206 ARMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20539 SOX13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.143 PR-DUB complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.175 CLPTM1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30391 G1/S transition of mitotic cell cycle GO Biological Process Annotations 2023 1.0 null MOCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66678 Sarcoma_SARC_TCGA-DX-A1L2-01A-22R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE154246_2_v_3_haspin_mouse RummaGEO Gene Perturbation Signatures -1.0 null Outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.588 CHST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51241 NAPRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67408 PDX1 JASPAR Predicted Transcription Factor Targets 1.0 null Perturb_13259_KO_Pcgf5_SRP115638 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 EFO21 CCLE Cell Line Gene CNV Profiles 1.0 1.54727 GSE120413,GSE120447_3_v_2_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null Azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.619 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41547 PHGDH_KO_GDS2874_125_mouse_embryonic head tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11242 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.02465 Dorsal claustrum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.890192 CDKN2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18954 KE39 CCLE Cell Line Gene CNV Profiles 1.0 1.54352 fertility GeneRIF Biological Term Annotations 1.0 null Infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.237 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.99201 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null idiopathic GeneRIF Biological Term Annotations 1.0 null DTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94929 nucleotide GeneRIF Biological Term Annotations 1.0 null c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.841834 GSE199255,GSE199356_4_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null UBE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41699 impaired GeneRIF Biological Term Annotations 1.0 null SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_5204_KO_Rara/Rarb/Rarg_SRP136599 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 RAB7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52072 DHRS13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5505 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.56115 UBE2L3 Pathway Commons Protein-Protein Interactions 1.0 null Neoplasm Metastasis DisGeNET Gene-Phenotype Associations 1.0 null Scrotum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.799 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.875004 Syndromic intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.038 HCC1599 CCLE Cell Line Gene CNV Profiles 1.0 2.35498 ARTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01491 individuals GeneRIF Biological Term Annotations 1.0 null PLCG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06236 BBS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17851 RET_mutant_23_GDS3319 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.57833 SHD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22173 WM35 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRCA1-A complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.058 Perturb_13258_KO_Pcgf3/Pcgf5_SRP115638 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.1587 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040212 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.58782 RAB9A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69167 KCNN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71003 FLI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42195 JHH2 CCLE Cell Line Gene Expression Profiles -1.0 -1.82994 MFSD13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10154 NR3C1 JASPAR Predicted Transcription Factor Targets 1.0 null catabolic process GO Biological Process Annotations 2015 1.0 null CLIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00898 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KEAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08859 LB996-RCC COSMIC Cell Line Gene Mutation Profiles 1.0 null Esophageal Carcinoma DisGeNET Gene-Disease Associations 1.0 null Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null protein modification process GO Biological Process Annotations 2015 1.0 null UBE2F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62849 ZBTB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26647 NKX6-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.3031 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20X-01A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PROX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56769 Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DHDDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83184 Homomeric SMAD protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.842 PMC7244323-elife-55325-supp3.xlsx-Noordermeer_TP53-KO-Gene_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GSE241701_1_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.195 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.00212 Warburg micro syndrome 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.111 Oligoasthenoteratozoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 ARPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95741 ETFBKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87905 changes GeneRIF Biological Term Annotations 1.0 null Liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.1 EFNB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45684 H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular catabolic process GO Biological Process Annotations 2015 1.0 null Female accessory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.514 negative GeneRIF Biological Term Annotations 1.0 null Plasma membrane bounded cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62S-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null acquired immunodeficiency syndrome DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 SMC3_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NY COSMIC Cell Line Gene Mutation Profiles 1.0 null HEATR5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01131 SKMES1 CCLE Cell Line Gene CNV Profiles -1.0 -1.42331 MEIOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52313 SPATA13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70325 Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LNZTA3WT4 COSMIC Cell Line Gene Mutation Profiles 1.0 null Gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.036 SHG-44 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.661 amygdaloid complex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.887446 JMSU1 CCLE Cell Line Gene CNV Profiles 1.0 1.40028 GSE174383_2_v_7_ly6d_mouse RummaGEO Gene Perturbation Signatures -1.0 null SK-OV-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null RSF complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.527 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.543 PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null TSPAN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21391 GSE120413,GSE120447_4_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HOXC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5436 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36956 PAX6-23342162-BETA-FORBRAIN-LENS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null DMS454 CCLE Cell Line Gene CNV Profiles -1.0 -2.19884 GSE174383_2_v_0_ly6d_mouse RummaGEO Gene Perturbation Signatures -1.0 null within GeneRIF Biological Term Annotations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUN-21703547-K562-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null RAD21_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO Biological Process Annotations 2025 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null H3K9me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SP in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.992201 ABRAXAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65552 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.846227 GSE168807_0_v_8_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.969493 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4987-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9879 GSE139911_0_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null RH30 CCLE Cell Line Gene CNV Profiles -1.0 -1.34803 SH3GLB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69872 GATA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54697 TAF1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24694 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.931409 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ADAMTSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8055 BICR16 CCLE Cell Line Gene CNV Profiles -1.0 -1.60888 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81G-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BARX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.1254 ARL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76725 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04907 PMC11399095-44161_2024_532_MOESM14_ESM.xlsx-Sheet1-Supplementary_Table_13_DEG_in_the_AA_borderzone_in_AF_vs_SR_patients_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null EPHX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14487 MAGOH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85112 vomeralnasalorgan.VMO. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.22654 Sertoli Cell-Only Syndrome CTD Gene-Disease Associations 1.0 2.88009 DBT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73106 GSE178714_1_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.1761 PPARGC1B_Hypomorphic Mutation_GDS2515_695_mouse_Skeletal muscle - (quadriceps muscles) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null hydrolase activity GO Molecular Function Annotations 2015 1.0 null GNAO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49127 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.833642 ESR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74069 difference GeneRIF Biological Term Annotations 1.0 null Aggresome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.95 Manchette COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.906 GAS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99003 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Chromosomal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.068 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTR Pathway Commons Protein-Protein Interactions 1.0 null SW156 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33745 ATG9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60037 primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.690042 GOLT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59797 Glioblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.315 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7758 9+2 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.005 ERBB2_knockdown_233_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.97588 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JD-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75287 496100285_TCx_probable Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.49954 origin GeneRIF Biological Term Annotations 1.0 null dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20907 polymorphisms GeneRIF Biological Term Annotations 1.0 null GSE199255,GSE199356_4_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null NKX6-1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5846 Micropyle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.76 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60112 BRCA1-C complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.652 SG in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.99201 increased circulating triglyceride level IMPC Knockout Mouse Phenotypes 1.0 null MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.690912 H2AFZ ENCODE Transcription Factor Targets 1.0 null MZ7-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.393442 RSBN1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47025 Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.189 regulation of biological process GO Biological Process Annotations 2015 1.0 null NECTIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06477 GPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70503 ZNF808 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06233 C11orf71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18014 HSPA4 Pathway Commons Protein-Protein Interactions 1.0 null BPNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47671 Brain Lower Grade Glioma_LGG_TCGA-DB-A75O-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RHOQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69551 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.392 ZNF135 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89956 CERS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23896 GSE205163,GSE205164_5_v_4_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null C8orf76 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32861 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25368 non-syndromic X-linked intellectual disability 99 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.313 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE220914_1_v_0_zdhhc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NAGPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1724 INPP5E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06443 GSE126621,GSE126920_1_v_0_dppa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null SLC22A17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64929 PMC7910580-41467_2021_21715_MOESM3_ESM.xlsx-DUBs_screen-Supplementary_Data_1_Results_of_DUB_shRNA_screen_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null oligozoospermia GeneRIF Biological Term Annotations 1.0 null ANOS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0751 HET-1A cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.178 PHC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51546 U-373MG cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.543 YPEL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92099 CELF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35214 protein deubiquitination GO Biological Process Annotations 2015 1.0 null Azoospermia DisGeNET Gene-Disease Associations 1.0 null MZ in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.4151 TE-12 COSMIC Cell Line Gene Mutation Profiles 1.0 null EMILIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54335 TRPM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55749 testicular GeneRIF Biological Term Annotations 1.0 null TCF7L2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5322 GSE199255,GSE199356_3_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null F2R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01995 GSE240258_0_v_1_prmt1_human RummaGEO Gene Perturbation Signatures -1.0 null DUSP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95905 south GeneRIF Biological Term Annotations 1.0 null PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR Rummagene Transcription Factor Associations 2026 1.0 null showed GeneRIF Biological Term Annotations 1.0 null CSGALNACT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25121 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05896 Prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.5 caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14843 Prostate adenocarcinoma_PRAD_TCGA-VP-A87K-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OE19 CCLE Cell Line Gene Expression Profiles 1.0 1.83669 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 624 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59161 TUBA1C Pathway Commons Protein-Protein Interactions 1.0 null PCDHB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76513 TGF-beta_OE_GDS2974_137_mouse_corneas GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null RANGRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2551 GSE101336_1_v_2_decitabine_mouse RummaGEO Drug Perturbation Signatures -1.0 null DOC2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81097 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null X-linked monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.144 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 96.5303 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Male pronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.506 SAP30 ENCODE Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.872231 BATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4434 CMLT1 DepMap CRISPR Gene Dependency 1.0 3.62948 TYK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89744 SK-MEL-28 COSMIC Cell Line Gene Mutation Profiles 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE74251_2_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null KU812 COSMIC Cell Line Gene Mutation Profiles 1.0 null SOX2_Deficiency_GDS4853_321_human_AZ-521 gastric cancer (GC) cell line - 18 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SOX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33137 SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.634487 EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96124 regulation of proteasomal ubiquitin-dependent protein catabolic process GO Biological Process Annotations 2025 1.0 null inner CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05175 viral infectious disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48896 SNU601 CCLE Cell Line Gene CNV Profiles 1.0 1.4487 small intestine GTEx Tissue Gene Expression Profiles -1.0 -1.17497 CNST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98051 RHJT DepMap CRISPR Gene Dependency 1.0 3.67762 COL18A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27437 NBT-II cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.937 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81F-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MFSD14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41678 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Hypogonadism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.354 HS611T CCLE Cell Line Gene Expression Profiles -1.0 -1.94314 CMK115 DepMap CRISPR Gene Dependency 1.0 2.1095 MDAMB361 CCLE Cell Line Gene CNV Profiles -1.0 -1.70548 protein modification by small protein conjugation or removal GO Biological Process Annotations 2015 1.0 null GSE173911,GSE173917_0_v_1_morc3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.703 NCI-SNU-5 COSMIC Cell Line Gene Mutation Profiles 1.0 null Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.104 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.769855 SP in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.881389 Lung adenocarcinoma_LUAD_TCGA-97-7546-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-5143-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null decreased male germ cell number MGI Mouse Phenotype Associations 2023 1.0 null macromolecule modification GO Biological Process Annotations 2015 1.0 null 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.12826 CANT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66341 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X1-01A-12R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CYB561 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84918 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33826 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.909824 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null haplotype GeneRIF Biological Term Annotations 1.0 null SLC39A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71676 TRMT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2267 ADRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63127 GSE180185_7_v_1_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null WDR74 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51042 NIPSNAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96275 anterior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.85111 three GeneRIF Biological Term Annotations 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUN-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE144115_4_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PCF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41587 estradiol_mus musculus_gpl4134_gse23241 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE79663_2_v_0_tcf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null SOCS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38532 PALD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26339 primary auditory cortex (core)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12449 NCIH2444 CCLE Cell Line Gene Expression Profiles -1.0 -1.88907 ARF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82131 DK-MG COSMIC Cell Line Gene Mutation Profiles 1.0 null NIPSNAP3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85007 east GeneRIF Biological Term Annotations 1.0 null CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DNASE1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56096 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11197 Disease Susceptibility HuGE Navigator Gene-Phenotype Associations 1.0 null CTSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67338 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.94445 PRDM14-21183938-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Hereditary ataxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.52 PTPN13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98953 subnuclear GeneRIF Biological Term Annotations 1.0 null ZSCAN25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17473 EEF2 Pathway Commons Protein-Protein Interactions 1.0 null USHBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78411 PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR Rummagene Transcription Factor Associations 2026 1.0 null Perturb_5145_KO_H3f3a/H3f3b_ERP109384 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.66777 PRDM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39232 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05896 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.75877 cellular protein modification process GO Biological Process Annotations 2015 1.0 null Mitochondrial derivative COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.529 MAP3K4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49255 hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.856958 HLA-E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57875 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06109 GSE224969,GSE224971_0_v_1_chtop_mouse RummaGEO Gene Perturbation Signatures -1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null Adult Glioblastoma DisGeNET Gene-Disease Associations 1.0 null Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.221 Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37231 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RH-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Subfertility, Male DisGeNET Gene-Phenotype Associations 1.0 null Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.296 mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null NB17 DepMap CRISPR Gene Dependency 1.0 6.24225 dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null pyramidal cells of rostral CA4 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34857 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2257 253JBV CCLE Cell Line Gene Expression Profiles 1.0 1.35325 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRPM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84564 HMBOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25883 Perturb_17329_KO_Dis3l2_SRP288575 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.30925 GSE68156_3_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null FKBP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57176 regulation of cellular process GO Biological Process Annotations 2015 1.0 null JUN ChEA Transcription Factor Targets 1.0 null related GeneRIF Biological Term Annotations 1.0 null organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05645 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.14516 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.485156 CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.995987 DNAJC2-21179169-NT2-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null IRF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1051 HECTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94301 SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06127 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10363 THOC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73556 cell part GO Cellular Component Annotations 2015 1.0 null Sperm flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.253 FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.9928 CDC37L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68259 HT115 CCLE Cell Line Gene Expression Profiles -1.0 -2.41503 UIMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63409 motility GeneRIF Biological Term Annotations 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8334-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BARHL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3028 ZNF284 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96833 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 HCC1419 COSMIC Cell Line Gene Mutation Profiles 1.0 null RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.871362 T3M10 CCLE Cell Line Gene CNV Profiles 1.0 1.48496 JHH-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null proteasomal protein catabolic process GO Biological Process Annotations 2015 1.0 null buccal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.555671 HDHD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1754 paravermis of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19097 SYDE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21008 Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null mRNA_DLX3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null HM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86811 ZFPM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22927 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.427 LMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65476 inner CP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.944363 regulation of cellular catabolic process GO Biological Process Annotations 2015 1.0 null POU2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9464 AGO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.046 INKA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84452 DPY30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46259 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17767 cysteine-type peptidase activity GO Molecular Function Annotations 2023 1.0 null LEMD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94175 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RY-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052008 CSTB_KO_GSE47516_678_mouse_mouse cerebellum at P30 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MTMR11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73603 TTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35869 MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.745388 PMC7862630__F3 PFOCR Pathway Figure Associations 2024 1.0 null GPR62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22346 NCI-H2110 COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7R3-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RUNX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9185 MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.01 K029AX CCLE Cell Line Gene Expression Profiles -1.0 -2.02928 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12449 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.279 JUN::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.0526 TMEM165 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52885 female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EJM CCLE Cell Line Gene Expression Profiles 1.0 2.40871 496100412_FWM_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.50387 ERRFI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33874 NCIH1781 CCLE Cell Line Gene CNV Profiles 1.0 1.58892 Varicocele DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.639 AICDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88468 spermatogenic GeneRIF Biological Term Annotations 1.0 null blood GTEx Tissue Gene Expression Profiles 1.0 1.0968 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QD-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GJA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32838 MDAMB436 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.16041 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.876073 PMC3944256-cddis201440x1.xls-Primary_Screen_Results-Supplementary_Table_1_Synthetic-Lethal_siRNA_DUB_Screen_for_Mcl1_antagonists_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37433 JUNB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29946 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00839 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 protein modification by small protein removal GO Biological Process Annotations 2015 1.0 null Warburg micro syndrome 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.053 Oligospermia HuGE Navigator Gene-Phenotype Associations 1.0 null PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null STRN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57663 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.976996 azoospermia; infertility, male; oligospermia GAD Gene-Disease Associations 1.0 null HIV Infections HuGE Navigator Gene-Phenotype Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KRCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63851 NCC021 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX Rummagene Transcription Factor Associations 2026 1.0 null Peptidase C19, ubiquitin carboxyl-terminal hydrolase InterPro Predicted Protein Domain Annotations 1.0 null OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82519 VP229 DepMap CRISPR Gene Dependency 1.0 2.74958 GSE238018_3_v_4_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null pi-body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.503 RAB3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43274 PRC1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.412 OSBPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68622 mRNA_SOX9_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null HCC1500 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.71417 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.11822 GNAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21415 posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.99085 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.916 common GeneRIF Biological Term Annotations 1.0 null NANOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10087 496100376_FWM_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.60274 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03901 TBX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91655 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896031 ENGASE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46454 Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.206 severe GeneRIF Biological Term Annotations 1.0 null FASTKD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76406 SPARC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48658 SKNAS CCLE Cell Line Gene Expression Profiles 1.0 1.47255 populations GeneRIF Biological Term Annotations 1.0 null gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ATAD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.4181 YDJC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2559 CHSA0108 COSMIC Cell Line Gene Mutation Profiles 1.0 null Vas deferens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.259 HNRNPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33537 FAM20B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84517 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32773 Perturb_16611_KO_Np95_SRP311865 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 NKX3-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25469 HMGB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59602 Male Infertility DisGeNET Gene-Phenotype Associations 1.0 null NME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54041 hernia, inguinal; infertility, male GAD Gene-Disease Associations 1.0 null ZNF787 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.24547 DGUOK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57627 significant GeneRIF Biological Term Annotations 1.0 null SNX21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8629 PHF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69601 KBM-5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.802 496100502_TCx_dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.64828 dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65019 affect GeneRIF Biological Term Annotations 1.0 null NCKAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13261 CLDND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9804 TCEAL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51415 HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.8472 DNAJC2 ChEA Transcription Factor Targets 1.0 null ZNF354C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8125 MRPL13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26721 Cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16188 NR2F2_01_07 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59413 HCC1806 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 CEBPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3806 striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42127 Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SQ1 CCLE Cell Line Gene CNV Profiles 1.0 1.35991 DMS153 CCLE Cell Line Gene CNV Profiles 1.0 1.3338 SNRPB Pathway Commons Protein-Protein Interactions 1.0 null TMEM216 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66677 DDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16364 B4GALT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74072 KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82684 HS-683 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.601 Fanconi anaemia nuclear complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.555 SCML4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56068 Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.122 TRIM35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32561 CD200 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55404 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.500398 9+2 motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.0071 SARS-CoV MA15_Day2-PFU-10^3_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.94643 496100330_PCx_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.01661 ICAM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30406 CLDN15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20488 Kidney Chromophobe_KICH_TCGA-KO-8408-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE233679_14_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null cell cycle G1/S phase transition GO Biological Process Annotations 2025 1.0 null LRP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07486 sperm GeneRIF Biological Term Annotations 1.0 null SOX5 JASPAR Predicted Transcription Factor Targets 1.0 null deubiquitinase activity GO Molecular Function Annotations 2025 1.0 null Sperm head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.53 cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.940057 DUBm complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.739 ACTN4 Pathway Commons Protein-Protein Interactions 1.0 null NUFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1305 PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null disease by infectious agent DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 PRDM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51435 receptors GeneRIF Biological Term Annotations 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8335-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of catabolic process GO Biological Process Annotations 2015 1.0 null EFCAB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00577 orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.878 testosterone; infertility, male; hypogonadism GAD Gene-Disease Associations 1.0 null DDX20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6159 CASP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79455 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20194 SLC16A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04865 496100277_FWM_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.27184 GADD45A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72031 Brain Lower Grade Glioma_LGG_TCGA-HW-8319-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.368 PLEKHA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23718 Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE214161,GSE214233_0_v_2_zmym2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MG63 DepMap CRISPR Gene Dependency 1.0 3.38068 increased eosinophil cell number IMPC Knockout Mouse Phenotypes 1.0 null TUBA1A Pathway Commons Protein-Protein Interactions 1.0 null endopeptidase activity GO Molecular Function Annotations 2023 1.0 null PITX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.3249 CDKN2A Pathway Commons Protein-Protein Interactions 1.0 null GSE220600_1_v_2_clpp_mouse RummaGEO Gene Perturbation Signatures 1.0 null binding GO Molecular Function Annotations 2015 1.0 null GSE195786_0_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PCDHB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08163 Hypogonadism HuGE Navigator Gene-Phenotype Associations 1.0 null negative regulation of proteasomal protein catabolic process GO Biological Process Annotations 2025 1.0 null mRNA_NR2F2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE77108_8_v_1_saha_human RummaGEO Drug Perturbation Signatures -1.0 null ALDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85758 proteolysis GO Biological Process Annotations 2015 1.0 null cell property TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.152848 MRPL43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06962 THOC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00538 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null 496100413_FWM_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.89751 regulation of proteolysis GO Biological Process Annotations 2015 1.0 null BT20 CCLE Cell Line Gene CNV Profiles 1.0 2.00702 intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null Nuclear lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 causing GeneRIF Biological Term Annotations 1.0 null GSE138818_1_v_0_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11872 CEP78 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74984 HSPA9 Pathway Commons Protein-Protein Interactions 1.0 null respectively GeneRIF Biological Term Annotations 1.0 null RAB11FIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.433 lm2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.794 POU3F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9971 ES4 DepMap CRISPR Gene Dependency 1.0 3.27384 NUDUL1 CCLE Cell Line Gene Expression Profiles 1.0 2.02227 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.84826 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null nucleus GO Cellular Component Annotations 2025 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BID CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18601 Alpha DNA polymerase:primase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.657 indicates GeneRIF Biological Term Annotations 1.0 null supporting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.509027 excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054085 DPY19L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22615 GAPDH Pathway Commons Protein-Protein Interactions 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.379 Pachytene cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.47 Sertoli cell-only syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.512 OV90 CCLE Cell Line Gene Expression Profiles -1.0 -1.73813 EBF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71149 variation GeneRIF Biological Term Annotations 1.0 null FAM168A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79749 ANLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58428 ERBB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5018 Cryptorchidism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.295 TERF2IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61352 DMS114 CCLE Cell Line Gene CNV Profiles -1.0 -1.40696 OV-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null outer SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.96219 MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.02071 NDUFA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91832 HSP90AA1 Pathway Commons Protein-Protein Interactions 1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.139 A3KAW CCLE Cell Line Gene CNV Profiles -1.0 -1.45965 CASKIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.69487 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.77353 Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null biological regulation GO Biological Process Annotations 2015 1.0 null H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5180_KO_Lb1/Lmnb2/Lmna_SRP092589 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.48452 RECQL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52703 risk GeneRIF Biological Term Annotations 1.0 null SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22565 Embryonic germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.685 VCB complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.668 URB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.061 JHH1 CCLE Cell Line Gene Expression Profiles 1.0 1.45096 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040437 Adolescent Idiopathic Scoliosis DisGeNET Gene-Disease Associations 1.0 null ZCCHC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85697 posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.39552 RASD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65596 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12726 Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.22 Lung adenocarcinoma_LUAD_TCGA-55-6712-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH441 CCLE Cell Line Gene Expression Profiles -1.0 -2.08426 RAB17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93004 ITK_defectivemutant_125_GSE28200 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.76868 cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null PTBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34031 GSE98898_7_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TSR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8845 ubiquitination GeneRIF Biological Term Annotations 1.0 null C15orf61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95299 sequencing GeneRIF Biological Term Annotations 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8435-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47355 ERBB2_knockdown_236_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.12904 primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11872 K48-linked deubiquitinase activity GO Molecular Function Annotations 2025 1.0 null NKAPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29678 HNRNPC Pathway Commons Protein-Protein Interactions 1.0 null NCIH841 CCLE Cell Line Gene CNV Profiles -1.0 -1.80802 ZNF28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37156 PMC2840217__F9 PFOCR Pathway Figure Associations 2024 1.0 null CHGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1894 ZNF831 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.51227 Perturb_16810_KD_Setd7_SRP075653 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.51673 TE-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.047 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.25985 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_1_GSC Rummagene Transcription Factor Associations 2026 1.0 null ZNF580 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.4706 PAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60924 CCDC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11966 SPECC1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73963 UBE2H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58068 increased basophil cell number IMPC Knockout Mouse Phenotypes 1.0 null PROKR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72705 seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.483986 SNU-283 COSMIC Cell Line Gene Mutation Profiles 1.0 null nucleus GO Cellular Component Annotations 2023 1.0 null B4GALT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8542 PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null IRF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.1667 Oligospermia DisGeNET Gene-Disease Associations 1.0 null mRNA_ZSCAN4C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.898866 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22616 RPS6KA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02518 PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT Rummagene Transcription Factor Associations 2026 1.0 null Synaptonemal structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.497 FEZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52078 RALGDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.29013 EEF2K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69715 Abortion, Habitual HuGE Navigator Gene-Phenotype Associations 1.0 null oral mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.238108 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FBXL14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21048 Male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.719 NRIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07055 LMBR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23871 USP38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78711 TRAM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7268 ABCB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60441 ZR75B Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.832223 mitotic cell cycle phase transition GO Biological Process Annotations 2025 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HLFA CCLE Cell Line Gene Expression Profiles -1.0 -1.52791 Prostate adenocarcinoma_PRAD_TCGA-EJ-5521-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RTN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35405 ETS1-21867929-TH2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC9323628__F3 PFOCR Pathway Figure Associations 2024 1.0 null SPSB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53727 High grade glioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.331 protein metabolic process GO Biological Process Annotations 2015 1.0 null BE-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRCA1 JASPAR Predicted Transcription Factor Targets 1.0 null Myelomonocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.248 FOXO1::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2433 CENPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15437 AKT1S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2699 SESN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56921 GOLM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63233 HNRNPA2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47804 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09669 PTPN14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36695 GSE181821_1_v_3_mov10_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DY-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65048 TUBB Pathway Commons Protein-Protein Interactions 1.0 null PRKAB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53014 496100464_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.7571 SMAD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74283 Childhood Glioblastoma DisGeNET Gene-Disease Associations 1.0 null Sarcoma_SARC_TCGA-SI-A71O-06A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCT4-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.344 ZNF606 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19304 MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.7 regulation of intracellular steroid hormone receptor signaling pathway GO Biological Process Annotations 2025 1.0 null SMAD3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ISL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3527 GSE199255,GSE199356_3_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH929 CCLE Cell Line Gene CNV Profiles 1.0 1.4049 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33267 PHYHIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67354 HELLS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6043 GSE133213_6_v_5_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null TARBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57594 african GeneRIF Biological Term Annotations 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null Preosteoclast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.774 parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.857066 FOXO1::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.7121 Cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 EI24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66064 HCFC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81204 lung GTEx Tissue Gene Expression Profiles 1.0 0.824107 QARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09249 HOXA7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6115 OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.883912 CARNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78293 Kco TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.91 regulation of macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELOF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03639 HS870T CCLE Cell Line Gene Expression Profiles 1.0 1.65054 Autosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.12 ELK1::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6434 PAIP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71823 MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7596 SELENOK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71166 TNFRSF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31505 CNFN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1871 LN382 CCLE Cell Line Gene Expression Profiles -1.0 -1.95486 ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4785 POLR2A ENCODE Transcription Factor Targets 1.0 null TCF7L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98532 striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.946586 internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.02162 KLF13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10532 UBE2Z CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8093 mRNA_MYC_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Perturb_5100_KO_Zmym2_SRP161512 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 RRP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21255 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040288 LMO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7774 ZNF316 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23651 Meiotic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.446 SH2D2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14153 HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF876P CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93129 outer CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.830161 PRKCI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79979 RI1 CCLE Cell Line Gene Expression Profiles -1.0 -1.972 samples GeneRIF Biological Term Annotations 1.0 null reproduction GeneRIF Biological Term Annotations 1.0 null AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null proteolysis involved in cellular protein catabolic process GO Biological Process Annotations 2015 1.0 null rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.91172 PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT Rummagene Transcription Factor Associations 2026 1.0 null Ubiquitin specific protease domain InterPro Predicted Protein Domain Annotations 1.0 null Testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.073 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.463013 closely GeneRIF Biological Term Annotations 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null GSE176389_0_v_1_tet1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37041 NOLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87705 SELENOF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24268 Implantation fossa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.711 arrest GeneRIF Biological Term Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UNKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38826 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Ejaculatory duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.685 LRRC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47499 trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.37131 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.84826 SW837 CCLE Cell Line Gene Expression Profiles 1.0 1.63161 C17orf97 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33212 KLHDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33418 MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null hormoneinduced GeneRIF Biological Term Annotations 1.0 null LSM14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95933 SLC5A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68375 haplotypes GeneRIF Biological Term Annotations 1.0 null RBM39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82096 CDX2-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE134412_0_v_1_siah2_mouse RummaGEO Gene Perturbation Signatures 1.0 null myoepithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.412771 PMC11645450-MCO2-5-e70036.nxml-TABLE_1-DUB_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null INSIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9587 AMH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37957 stratum pyramidale of rostral CA3 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20052 inner CP in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13416 NCIH1385 CCLE Cell Line Gene CNV Profiles 1.0 1.35454 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.33 HOXB7-26014856-BT474-HUMAN ChEA Transcription Factor Targets 2022 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null AP3D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65996 PSENEN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0363 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852608 follicle-stimulating hormone complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.704 USP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64226 HOXB8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1605 SNUC1 CCLE Cell Line Gene Expression Profiles 1.0 1.93265 cellular_component GO Cellular Component Annotations 2015 1.0 null KIF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4568 Spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.999 Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE100863,GSE100864_2_v_1_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null G1/S transition of mitotic cell cycle GO Biological Process Annotations 2025 1.0 null DNAL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17391 YWHAG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66729 protein binding GO Molecular Function Annotations 2015 1.0 null SEMA6C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64127 MHH-PREB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null androgen GeneRIF Biological Term Annotations 1.0 null PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05896 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.739297 COLO-357 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.726 Semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.111 IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 84.1591 G2E3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38165 H3K9me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38716 Machado-Joseph disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.898 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.440274 CGB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2514 GSE241701_2_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null Spermatogenic failure 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.331 ZNHIT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0858 Lung adenocarcinoma_LUAD_TCGA-05-4244-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VENTX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4721 Perturb_5715_KO_Chaf1a_ERP006640 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.80838 ZEB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60683 Female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.261 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.976996 including GeneRIF Biological Term Annotations 1.0 null NUDT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2198 PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT Rummagene Transcription Factor Associations 2026 1.0 null ARID3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33191 GSE248858_4_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null PARD6G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16272 SNU449 CCLE Cell Line Gene CNV Profiles -1.0 -1.88536 outer CP in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.853315 SW1573 CCLE Cell Line Gene CNV Profiles -1.0 -2.09606 Perturb_17701_KO|KD_Pds5a|Stag1_SRP365503 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 NCI-H2347 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5010-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stomach cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 modification-dependent macromolecule catabolic process GO Biological Process Annotations 2015 1.0 null Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.5083 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of primary metabolic process GO Biological Process Annotations 2015 1.0 null HCC1143 CCLE Cell Line Gene CNV Profiles 1.0 2.09602 subsaharan GeneRIF Biological Term Annotations 1.0 null IKZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6751 C3orf18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45239 ARFGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4014 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.48548 SW954 DepMap CRISPR Gene Dependency 1.0 2.22182 YY1_KD_GDS3788_488_human_HeLa GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Chromosomal duplication syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.204 TOMM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53629 FOXC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.7599 infertility GeneRIF Biological Term Annotations 1.0 null H4K20me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15795 CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF345 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83371 protein modification by small protein removal GO Biological Process Annotations 2023 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4825 TOLLIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19026 l-929 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.529903 Perturb_5057_OE_Mir344_SRP161512 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 RUNX1_KO_GDS1511_251_mouse_Embryos at E12 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962646 DYNC1LI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17983 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.22265 NME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09511 FBXO17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28256 Lung adenocarcinoma_LUAD_TCGA-55-6981-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBE3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28077 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29429 NFIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85895 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20914 PRMT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94588 Inguinal hernia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.091 MIEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25168 CAPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06757 mdamb157 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.629 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.911 FOSL1::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.876 MYL12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64777 sertoli GeneRIF Biological Term Annotations 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null negative regulation of ubiquitin-dependent protein catabolic process GO Biological Process Annotations 2025 1.0 null Ovarian disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.178 BCOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76832 POU2F1::SOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.4132 ZNF382 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.7479 Hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.045 FAM50B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66145 496100407_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.51513 USP17L7 Pathway Commons Protein-Protein Interactions 1.0 null Sperm fibrous sheath COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.616 Proteasome activator complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.729 PARP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60652 KYSE-30 COSMIC Cell Line Gene Mutation Profiles 1.0 null COMMD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.57829 regulation of proteolysis involved in cellular protein catabolic process GO Biological Process Annotations 2015 1.0 null organelle GO Cellular Component Annotations 2015 1.0 null GOLGA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69522 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.80201 MDA-MB-435S cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.733 AGRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95411 INHBE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72965 TPM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86611 PDCD6 Pathway Commons Protein-Protein Interactions 1.0 null COL9A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07272 GSE199606_1_v_0_csf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSS CCLE Cell Line Gene CNV Profiles -1.0 -2.35047 H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C8orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77473 MARF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10855 PROM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90418 ZNF883 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78362 ACLY Pathway Commons Protein-Protein Interactions 1.0 null UQCRQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78244 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CMK CCLE Cell Line Gene Expression Profiles 1.0 1.47881 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 regulation of cellular protein catabolic process GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2777-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Azoospermia, Nonobstructive DisGeNET Gene-Disease Associations 1.0 null KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28322 PRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89043 SAGA complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.0 SEPTIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22873 fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063753 Gynecomastia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.1 Serous carcinoma_Fallopian tube_GSE10971 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.47281 KRT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99671 pyramidal layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13303 RPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40092 Lung adenocarcinoma_LUAD_TCGA-91-6828-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NAGK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52559 ZNF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89731 CXCR7_Deficiency_GDS3183_604_mouse_Neonatal semilunar valves GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TP53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37498 SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.826757 outer CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.67148 TRIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01051 DSH1 COSMIC Cell Line Gene Mutation Profiles 1.0 null JHOS-4 COSMIC Cell Line Gene CNV Profiles -1.0 -3.7119 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.54313 regulation of metabolic process GO Biological Process Annotations 2015 1.0 null GSE155695,GSE155696_1_v_0_acetaminophen_mouse RummaGEO Drug Perturbation Signatures -1.0 null Female reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.205 ETV5::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3625 LMTK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.55859 MRPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12958 GSE127790_13_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.164 hernia GeneRIF Biological Term Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A7C4-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CELF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85325 Sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.76 UMRC7 DepMap CRISPR Gene Dependency 1.0 3.02392 mRNA_SALL4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.036 DOT1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6464 Perturb_4600_KO_Mettl3_SRP048598 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.967915 testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.24967 PMC6888741__F2 PFOCR Pathway Figure Associations 2023 1.0 null increased circulating luteinizing hormone level MGI Mouse Phenotype Associations 2023 1.0 null SLC35E3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3758 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A954-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.885374 CSTB_KO_GDS5090_200_mouse_Cerebellar granule cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null AM-38 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE154246_2_v_0_haspin_mouse RummaGEO Gene Perturbation Signatures 1.0 null RTN4RL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36192 Androgen insensitivity syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.585 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063766 INTS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66063 SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17268 22RV1 DepMap CRISPR Gene Dependency 1.0 8.28064 TFAP2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.258 Metabolism of proteins Reactome Pathways 2024 1.0 null GSE158285_0_v_1_ddx5_mouse RummaGEO Gene Perturbation Signatures -1.0 null REST_01_337 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.67615 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1144 PWWP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7444 prostate BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 RIPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07254 ZKSCAN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33004 NSFL1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00958 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_9718_OE_Wt1_SRP126738 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.55965 CELF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51352 PTPN9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74973 hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.878832 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22284 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CACNG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60152 PPP2R2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39008 Spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.057 ZBTB25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31552 SRSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41528 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.04487 TRABD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69308 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE101336_1_v_3_decitabine_mouse RummaGEO Drug Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.117 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974525 KANSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66098 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SK-01B-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null confirm GeneRIF Biological Term Annotations 1.0 null DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC3064265-NIHMS252278-supplement-3.xls-A_Interactions-Supplementary_Table_2_DUB_data_No_Control_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null COX8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32703 MEL-JUSO COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7860-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A85H-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Major mitochondrial derivative COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.041 gata4_16914500_e9dot5_atrioventricular_canal_lof_mouse_gpl1261_gds3663 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.878313 GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3815 SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3064 EFEMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50445 peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.363 GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PNPLA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48006 NCIH1836 DepMap CRISPR Gene Dependency 1.0 3.65853 C1orf210 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45569 transcriptional GeneRIF Biological Term Annotations 1.0 null PAX6 ChEA Transcription Factor Targets 1.0 null Proteasome regulatory particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.134 GSE199255,GSE199356_6_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Deubiquitination Reactome Pathways 2024 1.0 null inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24789 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.518034 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.674 han GeneRIF Biological Term Annotations 1.0 null Gonocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.248 CGTH-W-1 COSMIC Cell Line Gene CNV Profiles -1.0 -3.7119 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.51007 NUGC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE144115_2_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.2079 EMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62872 VZ in postamygdaloid region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.921412 inner CP in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.828042 GSE133213_10_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null VCX3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50396 SNCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25335 cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null SOX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.2733 UFM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82697 GSE147834_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE138818_1_v_3_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null Tectum mesencephali TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.759 male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.96708 Ovarian cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 UACC893 DepMap CRISPR Gene Dependency 1.0 7.19143 ZNF684 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.379 ZNF98 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76782 amygdaloid complex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.865382 GSE121043_0_v_1_aldh1a1_human RummaGEO Gene Perturbation Signatures -1.0 null Lateral element COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.498 Klinefelter syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.713 PPARA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38089 outer CP in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.977175 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IB-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63246 AFF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34457 Male infertility WikiPathways Pathways 2024 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8354-01A-31R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null negatively GeneRIF Biological Term Annotations 1.0 null MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 83.2802 ubiquitin-specific protease activity GO Molecular Function Annotations 2015 1.0 null Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.161 POU5F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1194 DTX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20979 R3HDM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68173 SRY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3571 HTR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9434 GSE168807_2_v_8_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null catalytic activity GO Molecular Function Annotations 2015 1.0 null RIDDLE syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.098 obstructive GeneRIF Biological Term Annotations 1.0 null U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00997 CDY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61273 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.37 Inhibin B complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.594 leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.610943 Synapsis initiation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.572 IL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08707 syndrome GeneRIF Biological Term Annotations 1.0 null HDAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52744 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A7U0-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF280A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5061 PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP Rummagene Transcription Factor Associations 2026 1.0 null TUHR10TKB DepMap CRISPR Gene Dependency 1.0 3.32865 GSE74251_0_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE84922,GSE84924_4_v_1_sall4_mouse RummaGEO Gene Perturbation Signatures -1.0 null SAV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1199 KPNSI9S CCLE Cell Line Gene Expression Profiles -1.0 -3.26982 cause GeneRIF Biological Term Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7542-01A-21R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53 Rummagene Transcription Factor Associations 2026 1.0 null LN-229 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852608 primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.870151 stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.985526 GSE77007_3_v_1_med23_mouse RummaGEO Gene Perturbation Signatures -1.0 null AU565 CCLE Cell Line Gene CNV Profiles -1.0 -1.40136 SKN COSMIC Cell Line Gene Mutation Profiles 1.0 null supportive connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.499223 ZSCAN21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9641 there GeneRIF Biological Term Annotations 1.0 null KLF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89873 HOXD9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4076 PF-382 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null decreased circulating follicle stimulating hormone level MGI Mouse Phenotype Associations 2023 1.0 null ERI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15483 DNAJC19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0572 CTCF ENCODE Transcription Factor Targets 1.0 null HLE CCLE Cell Line Gene Expression Profiles 1.0 2.23833 HID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51311 CHST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46199 Gonadal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.39 CREBL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5563 MZ in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0419 MEF2D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.1418 proteasome-mediated ubiquitin-dependent protein catabolic process GO Biological Process Annotations 2015 1.0 null FAM53C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1434 HNRNPA2B1 Pathway Commons Protein-Protein Interactions 1.0 null ALKBH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60795 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RAD51AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89282 FOXR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40446 TRIM71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16946 ARHGEF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86647 FADU CCLE Cell Line Gene CNV Profiles 1.0 1.3354 Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.348148 BSX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5093 CLIC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06621 TRMT61B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06346 PDE5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07916 RIN2 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63T-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LHX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2231 RAP1GAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37367 SW 780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89961 488395315_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10588 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PIKFYVE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18713 ZNF566 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4686 amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.930539 DNAJC2-21179169-NT2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null protein deubiquitination GO Biological Process Annotations 2023 1.0 null SKES1 CCLE Cell Line Gene CNV Profiles 1.0 1.77453 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YJ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PITX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86488 ZNF639 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01076 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.48477 FAIM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12272 taiwan GeneRIF Biological Term Annotations 1.0 null Spermatoproteasome complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.601 ubiquitin-like protein-specific protease activity GO Molecular Function Annotations 2015 1.0 null 496100351_FWM_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.51325 LZTR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77038 GK_KO_GDS1555_127_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11175 deubiquitinase activity GO Molecular Function Annotations 2023 1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.35104 ERAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47215 counteract GeneRIF Biological Term Annotations 1.0 null Malignant astrocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.312 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.46952 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.72238 PMC8526018-KAUP_A_1856493_SM1378.xlsx-Table_S5-_DUB_genes-Table_S5_Compared_deubiquitinating_enzyme_genes_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null Ubiquitin specific protease, conserved site InterPro Predicted Protein Domain Annotations 1.0 null TBX20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12984 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Uterine Carcinosarcoma_UCS_TCGA-N5-A59F-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80881 Rectum adenocarcinoma_READ_TCGA-AG-4022-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW780 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE242199_6_v_5_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null EN2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.4493 C17orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39327 mRNA_SETDB1_19884255 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null alleles GeneRIF Biological Term Annotations 1.0 null EDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40896 H1-10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14438 GATA4_INACTIVATION_GDS3663_519_mouse_Endothelial-derived cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.2061 Lung adenocarcinoma_LUAD_TCGA-44-A47B-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_5565_KO_Tal1_SRP119777 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.97433 DDX3X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86359 Chiasma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.066 HOXB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6561 RPMI7951 CCLE Cell Line Gene CNV Profiles -1.0 -1.32702 SNU620 DepMap CRISPR Gene Dependency 1.0 4.67297 9+2 motile cilium GO Cellular Component Annotations 2025 1.0 null GSTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87093 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0154 RRAGC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89341 MEAF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.299 ZZZ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78927 SHISAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63327 SPG21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05892 RNF187 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70543 SNRPA Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HW-7491-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Y-linked spermatogenic failure 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.194 SRF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5061 SNAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35967 TM6SF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44113 molecular_function GO Molecular Function Annotations 2015 1.0 null KMS-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null exocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066198 GTF2IRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31882 JHH7 CCLE Cell Line Gene Expression Profiles 1.0 1.85816 JM1 CCLE Cell Line Gene Expression Profiles 1.0 1.64437 ubiquitin-dependent protein catabolic process GO Biological Process Annotations 2015 1.0 null Perturb_5169_KO_Ddx5_SRP068412 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.0298 ZMAT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30338 ACTMAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15255 AMMECR1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8697 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.43 mast cells BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.13254 H3K9me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null SMPD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93305 WDR86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87302 Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.429 WRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37712 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043067 MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.976996 PDIA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81003 Prostate adenocarcinoma_PRAD_TCGA-HC-7749-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF444 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16484 Lung adenocarcinoma_LUAD_TCGA-95-7947-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM186 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38442 HT1376 DepMap CRISPR Gene Dependency 1.0 2.06175 Cerebellar disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.511 H357 DepMap CRISPR Gene Dependency 1.0 4.97234 IRF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 128.391 HSD17B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73181 presence GeneRIF Biological Term Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TD-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRCA1-BARD1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.33 AGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80399 CCDC85B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03968 hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.898974 frequencies GeneRIF Biological Term Annotations 1.0 null sweat TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.506279 posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27627 496100390_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.33628 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19288 ZBTB46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11342 Zygotene cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.568 SNAP47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2326 Perturb_9719_OE_Wt1_SRP126738 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.5348 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47788 RF-48 COSMIC Cell Line Gene Mutation Profiles 1.0 null inner SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34031 maturation GeneRIF Biological Term Annotations 1.0 null ESCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59925 RHBDD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29851 PMC10350897-j_biol-2022-0528-S1.pdf-181-USF2_USF2 Rummagene Transcription Factor Associations 2026 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3742-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE133213_2_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE183271_4_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null TRAFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57853 BFAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36672 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03084 HNRNPLL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21709 LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06667 Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A9DB-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89016 GSE196671_6_v_8_obox4_mouse RummaGEO Gene Perturbation Signatures -1.0 null subgranular zone of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.891072 EMC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.2395 Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Transverse filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.944 ATG4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28079 COV434 CCLE Cell Line Gene Expression Profiles 1.0 1.47107 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62823 PMC12081856-41420_2025_2522_MOESM6_ESM.xlsx-Sheet_1-Table_S4_Complete_Gene_List_of_the_MEblack_Gene_Module_and_the_DUB_Family_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null assembles GeneRIF Biological Term Annotations 1.0 null GOLGA6L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68182 ACACB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36165 BT474 CCLE Cell Line Gene CNV Profiles -1.0 -1.36283 PMC8225676-41467_2021_24150_MOESM4_ESM.xlsx-DUB_ranking_siRNA_screening-DUB_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null ARL8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53148 C4orf3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61582 sertoli cell-only syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.45045 Primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.713 Lung adenocarcinoma_LUAD_TCGA-62-8397-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKBR3 CCLE Cell Line Gene CNV Profiles -1.0 -1.42801 ASAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0888 TUBB4B Pathway Commons Protein-Protein Interactions 1.0 null oligospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.740299 GSE150215_1_v_0_etl4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7485-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAICS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19185 TC71 CCLE Cell Line Gene Expression Profiles 1.0 1.86091 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 Kidney Chromophobe_KICH_TCGA-KN-8418-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PIGC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26374 GSE157592_1_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.950105 cysteine-type endopeptidase activity GO Molecular Function Annotations 2015 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3QE-01A-21R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRCA1-B complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.966 FAM229A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63719 FOXD4L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47183 CLUH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9172 Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null defect GeneRIF Biological Term Annotations 1.0 null DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.22265 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19287 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null allele GeneRIF Biological Term Annotations 1.0 null indicated GeneRIF Biological Term Annotations 1.0 null SH2B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6517 FBXW8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69278 NOCT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07674 SUDHL10 CCLE Cell Line Gene CNV Profiles 1.0 2.59998 OAW28 CCLE Cell Line Gene CNV Profiles 1.0 1.48217 TIMM8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55384 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00698 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.03302 Acquired hyperkeratosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 Spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.103 GSE120413,GSE120447_0_v_2_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ADAMTS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64832 disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7379-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XY body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.77 Brain Lower Grade Glioma_LGG_TCGA-DU-5853-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LYRM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26797 NCIH727 CCLE Cell Line Gene CNV Profiles -1.0 -1.69735 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22418 Spinal muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.259 UBE4B Pathway Commons Protein-Protein Interactions 1.0 null nucleus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Ectoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.869 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-6667-01A-12R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IFITM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6632 RNASEH2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37473 Adrenocortical carcinoma_ACC_TCGA-OR-A5JA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.867513 fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067347 ETNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84148 LYRM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.95925 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.434 YTHDF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69484 ubiquitinyl hydrolase activity GO Molecular Function Annotations 2015 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.939708 cd8.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959998 GSE200673,GSE200691_2_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85922 Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-MN-A4N4-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TC32 CCLE Cell Line Gene Expression Profiles 1.0 1.5155 REEP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05389 TP53BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36172 Perturb_5716_KO_Chaf1b_ERP006640 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.9658 nationality GeneRIF Biological Term Annotations 1.0 null myoepithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.516104 GSE130690,GSE130692_1_v_0_sirt6_mouse RummaGEO Gene Perturbation Signatures 1.0 null RNF145 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38637 AR ChEA Transcription Factor Targets 1.0 null SUM225CWN Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.29166 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.14942 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1116 PMC12855127-Table1.xlsx-Sheet1-Table_S1_A_total_of_576_E3_genes_and_95_DUB_genes_were_identified_in_the_iUUCD_2_0_database_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null AACS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48736 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H4-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM265 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58542 RAB22A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07979 SCAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.53352 amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.89385 EN COSMIC Cell Line Gene Mutation Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LJ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE142210_11_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.61947 SLC16A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31552 other GeneRIF Biological Term Annotations 1.0 null 496100360_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.23877 ARHGAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79696 spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.315498 HUPT4 CCLE Cell Line Gene CNV Profiles 1.0 1.85379 PMC7782476-41467_2020_20434_MOESM7_ESM.xlsx-KLF14_string_interactions-node2_KLF14 Rummagene Transcription Factor Associations 2026 1.0 null GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-IK-7675-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.008 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.45416 IARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0002 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.87 Kennedy's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.477 GCT DepMap CRISPR Gene Dependency 1.0 7.61243 FAM217B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48737 INO80B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8462 TMEM106C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00661 POU3F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7366 PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20194 SW579 CCLE Cell Line Gene CNV Profiles -1.0 -1.57548 PAX6-23342162-BETA-FORBRAIN-LENS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.397 GR-ST COSMIC Cell Line Gene Mutation Profiles 1.0 null PNRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19149 RCE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.47132 NFKB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63827 azoospermia GeneRIF Biological Term Annotations 1.0 null mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.21779 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81Q-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.90178 Perturb_9782_KD_Esrrb_SRP321923 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.37102 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE198165,GSE198166_5_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null SORD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86667 ABHD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17397 SMARCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14499 some GeneRIF Biological Term Annotations 1.0 null VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.67266 GSE113329,GSE113335_3_v_4_taf6l_mouse RummaGEO Gene Perturbation Signatures -1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SIAH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56138 MED22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63369 PMC7244323-elife-55325-supp3.xlsx-Haapaniemi_TP53-KO-Gene_TP53 Rummagene Transcription Factor Associations 2026 1.0 null HOXB9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.301 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.957071 Zfp36l2_deficiency_GDS3574_153_mouse_E14.5 fetal liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07749 GTF3C5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27075 GDAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66327 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.37915 PMC7244323-elife-55325-supp3.xlsx-This_paper_TP53-KO-Gene_TP53 Rummagene Transcription Factor Associations 2026 1.0 null oligozoospermia MGI Mouse Phenotype Associations 2023 1.0 null PNPLA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9134 ITPRIPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07869 BPNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27341 SSBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88456 LDOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32933 Brain Lower Grade Glioma_LGG_TCGA-HT-7902-01A-12R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.33763 FLO-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null DUSP1_Deficiency_GDS1606_765_mouse_Spleen GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null ZNF675 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60519 TRMT2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49963 Monopolin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.517 ABC1 CCLE Cell Line Gene CNV Profiles 1.0 1.45379 CANX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16157 polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13664 ACTB Pathway Commons Protein-Protein Interactions 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XK-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.903701 NOTCH_INHIBITION_GDS2794_61_human_MOLT4 (T-cell acute lymphoblast leukemia) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null WSU-NHL COSMIC Cell Line Gene Mutation Profiles 1.0 null cysteine-type endopeptidase activity GO Molecular Function Annotations 2023 1.0 null H3K9me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null Perturb_17699_KO_Pds5a_SRP365503 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.3083 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Acrosomal matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.545 testicular cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.342233 FKBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61221 HOXB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90726 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34772 GSE120413,GSE120447_0_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CSTB_KO_GDS5090_398_mouse_cerebella GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ZNF470 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44205 Perturb_5213_KO_Terc_SRP156128 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 LUBAC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.716 MESD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75089 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 TMEM41A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99052 POU5F1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4532 Benign pleural mesothelioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.281 18614019-TableS4c GeneSigDB Published Gene Signatures 1.0 null female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.731854 Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.252 GSE198165,GSE198166_5_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null CHMP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37451 Brain Lower Grade Glioma_LGG_TCGA-FG-7636-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAP3K1_knockout_245_GSE39240 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.36089 Sperm flagellum COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 NCIH2172 CCLE Cell Line Gene CNV Profiles -1.0 -2.00214 Ezh2_deficiency_GDS2717_141_mouse_lymph node T cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049775 SVIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17533 CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61464 RAJI DepMap CRISPR Gene Dependency 1.0 2.35473 COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15546 chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.085045 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.359 TUSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9587 ZIK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29788 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.885667 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.931409 UNC50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39924 DJM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.838416 PRAME CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09836 496100536_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.62254 COL9A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.57669 COLO 800 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63146 GLUD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77879 POLDIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10398 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41025 GSE199606_5_v_0_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null AAAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9856 CACNG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01472 JHH4 CCLE Cell Line Gene Expression Profiles 1.0 2.00431 ABAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96371 DCAF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47879 posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.78587 azoospermia; oligospermia GAD Gene-Disease Associations 1.0 null CYB5D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96507 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null ETV5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.05633 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.45929 intracellular organelle GO Cellular Component Annotations 2015 1.0 null HCC38 CCLE Cell Line Gene CNV Profiles 1.0 1.85856 CYYR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18977 KYSE-50 COSMIC Cell Line Gene Mutation Profiles 1.0 null SW948 DepMap CRISPR Gene Dependency 1.0 5.40804 primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.944383 TULP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82786 GSE124920_1_v_2_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Egg chorion COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.726 GSE203158_1_v_14_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREB3L4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4028 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15049 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5187-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null B3GNT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00777 ZBTB22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84917 Kidney Chromophobe_KICH_TCGA-KN-8426-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RTCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94591 LRFN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56189 TIMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56087 modification-dependent protein catabolic process GO Biological Process Annotations 2015 1.0 null SPIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72402 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852608 gfi1b_22201127_amulv_gof_mouse_gpl6246_gds4302 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.831004 Prostate adenocarcinoma_PRAD_TCGA-EJ-5522-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS695T CCLE Cell Line Gene CNV Profiles 1.0 2.21499 inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.01682 XYLT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18985 ASAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74936 PDXK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44509 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2003 SMIM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12479 GSE156907,GSE160237_1_v_0_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null MBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.37547 Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.21846 WDFY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36178 regulation of androgen receptor signaling pathway GO Biological Process Annotations 2025 1.0 null CHCHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97439 TRMT112 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10901 SUDHL10 DepMap CRISPR Gene Dependency 1.0 7.61654 intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Tcof1_OE_GDS998_154_mouse_neuroblastoma N1E-115 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2858-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null peptidase activity, acting on l-amino acid peptides GO Molecular Function Annotations 2015 1.0 null PDRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92321 leading GeneRIF Biological Term Annotations 1.0 null PLCB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67041 HMGXB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70038 C19orf53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54658 reduced male fertility MGI Mouse Phenotype Associations 2023 1.0 null GSE129186,GSE129223_0_v_1_aicda_mouse RummaGEO Gene Perturbation Signatures 1.0 null olfactory part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1521 RKN CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Congenital bilateral absence of vas deferens DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.562 PABPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79498 SH3BGRL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32959 SW1271 CCLE Cell Line Gene CNV Profiles 1.0 1.69278 Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 Scoliosis, Isolated, Susceptibility To, 3 DisGeNET Gene-Disease Associations 1.0 null EMSY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53081 SOHLH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77081 alterations GeneRIF Biological Term Annotations 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21747 HT144 DepMap CRISPR Gene Dependency 1.0 9.52524 ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.326406 OGFRL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61361 sweat gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.187942 peptidase activity GO Molecular Function Annotations 2015 1.0 null URI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10488 RAB24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50917 regulation of cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null GSE199255,GSE199356_6_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null MT-ND3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69415 Perturb_9781_KD_Ctnnb1_SRP321923 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.50204 UBC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31806 MICALL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59955 AML193 DepMap CRISPR Gene Dependency 1.0 2.26129 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.84826 HUH28 CCLE Cell Line Gene Expression Profiles -1.0 -2.42673 ULK1_knockout_197_GSE60778 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.7554 Brain Lower Grade Glioma_LGG_TCGA-HT-7686-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sex chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.464397 infertility, male GAD Gene-Disease Associations 1.0 null Squamous Cell Carcinoma Of Esophagus DisGeNET Gene-Disease Associations 1.0 null TRIM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35081 Male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.511 Seminal vesicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.956 orbital frontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29696 SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.944651 496100372_HIP_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 6.24297 Cytoplasmic ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.637 ERF::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5864 RPE1SS6 DepMap CRISPR Gene Dependency 1.0 2.20602 MAGEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64712 ZNF705B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89438 Leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.566 RIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18347 VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886511 OVK-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null Tumor Cell Invasion DisGeNET Gene-Phenotype Associations 1.0 null TOX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64595 DHX29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45078 GLI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42927 NCI-H847 COSMIC Cell Line Gene Mutation Profiles 1.0 null cofactors GeneRIF Biological Term Annotations 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46144 P2RX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01295 MIER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35569 HOXC9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9067 TMEM205 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.98597 kidney GTEx Tissue Gene Expression Profiles -1.0 -1.17497 CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199606_1_v_0_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.172396 DLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6281 ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4679 LEF1-29337183-MESC-MOUSE-STEM ChEA Transcription Factor Targets 2022 1.0 null NRDC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15456 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.142 caudal subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.960055 GSE137144_2_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null B4GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67524 ZNF337 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98863 MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.880496 caucasian GeneRIF Biological Term Annotations 1.0 null UPK3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89632 abnormal testis morphology MGI Mouse Phenotype Associations 2023 1.0 null primary motor cortex (area M1, area 4)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18812 TEX41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95245 salivary gland GTEx Tissue Gene Expression Profiles -1.0 -1.17497 BATF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0035 TMEM151A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26996 gonadal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.247852 SAP130 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74503 NCI-H211 COSMIC Cell Line Gene Mutation Profiles 1.0 null BARX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.679 OV7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.852608 ENSG00000170846 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69918 layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.919421 BACE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45814 endopeptidase activity GO Molecular Function Annotations 2015 1.0 null PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE195743_1_v_4_lhx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052303 1321N1 CCLE Cell Line Gene CNV Profiles -1.0 -1.54593 FGF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65073 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06109 SPRED3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41332 mitotic cell cycle phase transition GO Biological Process Annotations 2023 1.0 null MCM6 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_17700_KO|KD_Pds5a|Pds5b_SRP365503 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Perturb_5322_KD_Stag1_SRP244261 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.10942 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 human immunodeficiency virus infectious disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.368757 seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.553683 PRDM14-21183938-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TSN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96735 BEN CCLE Cell Line Gene CNV Profiles 1.0 1.64909 LAMA2_Deficiency_GDS3371_595_mouse_Hind limb skeletal muscle (4-week old dy3K/dy3K animals) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.438739 ZKSCAN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.52683 Male infertility due to globozoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.33 Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 male GeneRIF Biological Term Annotations 1.0 null APLN_KO_GDS3228_601_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null abnormal spermatogenesis MGI Mouse Phenotype Associations 2023 1.0 null PMC9886955-41420_2023_1325_MOESM12_ESM.xlsx-H6_14AvsH6_NC-Unnamed_2_HMX1 Rummagene Transcription Factor Associations 2026 1.0 null A498 CCLE Cell Line Gene Expression Profiles -1.0 -1.45915 GSE186647,GSE217288_2_v_4_hnrnpc_human RummaGEO Gene Perturbation Signatures -1.0 null SFXN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62874 RC-K8 COSMIC Cell Line Gene Mutation Profiles 1.0 null endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.054756 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q8-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27043 PMC6888741__F2 PFOCR Pathway Figure Associations 2024 1.0 null ZBTB17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34667 NNAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82962 H3K27me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE217694_4_v_0_pold1_mouse RummaGEO Gene Perturbation Signatures -1.0 null C2CD4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32719 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GDF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6957 ISL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3227 SHISA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19031 Brain Lower Grade Glioma_LGG_TCGA-DB-A4XF-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149870_0_v_1_pfn1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Vein disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 BAZ1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7048 NINJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71284 ovary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.945922 MYL12A Pathway Commons Protein-Protein Interactions 1.0 null Syndromic X-linked intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.172 SOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1138 HDAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61598 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199255,GSE199356_4_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null regulation of cellular metabolic process GO Biological Process Annotations 2015 1.0 null ARHGAP23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97628 Yo TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.36 AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06675 LRATD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74053 ACVR2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62299 POLR3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85153 SSTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42923 IGR1 CCLE Cell Line Gene CNV Profiles -1.0 -1.74844 FOXO1_KD_GDS2720_478_mouse_LSK GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NCI-H1734 COSMIC Cell Line Gene Mutation Profiles 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4795 GRK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36244 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.362 inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.892972 GSE217378_2_v_0_lin28b_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7403 SLC1A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10554 male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.7939 KDM6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73208 CL-40 COSMIC Cell Line Gene Mutation Profiles 1.0 null layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00435 RUVBL2 Pathway Commons Protein-Protein Interactions 1.0 null Cul2-RING ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.693 Kidney Chromophobe_KICH_TCGA-KL-8332-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KRT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40015 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease Progression HuGE Navigator Gene-Phenotype Associations 1.0 null PAK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13253 GSE63048_11_v_5_morc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5502-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF324 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93555 TE-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PHKG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4401 intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7792-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FIGLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63014 ES2 CCLE Cell Line Gene CNV Profiles -1.0 -1.64111 WIZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59112 HCC78 DepMap CRISPR Gene Dependency 1.0 2.40383 SLF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38048 parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.927468 DGKK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92534 GOT1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77042 MAIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63045 Spermatogenic failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.167 stratum pyramidale of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17249 ZNF530 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40595 PMC9225015-elife-72879-supp1.xlsx-DUB_CRISPR_library-Unnamed_3_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77979 RIMKLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70275 A172 CCLE Cell Line Gene CNV Profiles -1.0 -1.907 PMC9634082__F2 PFOCR Pathway Figure Associations 2024 1.0 null ASH-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null EHF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92793 appear GeneRIF Biological Term Annotations 1.0 null EPHA3 Pathway Commons Protein-Protein Interactions 1.0 null C1orf56 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67029 MMRN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40881 TNFSF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58907 thereby GeneRIF Biological Term Annotations 1.0 null TBX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4861 importance GeneRIF Biological Term Annotations 1.0 null HOXD8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2453 ZER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41512 NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14101 GSE125219,GSE125221_4_v_2_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null PSEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88989 MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF181 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85926 U266B1 CCLE Cell Line Gene Expression Profiles 1.0 1.37963 SW982 COSMIC Cell Line Gene Mutation Profiles 1.0 null KIF3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57961 complete GeneRIF Biological Term Annotations 1.0 null superior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.923705 CGTHW1 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 PMC5727433-41467_2017_2029_MOESM3_ESM.xls-Sheet1-Supplementary_Data_1_DUB_shRNA_list_used_in_this_study_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null PDCD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00549 LYPLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60981 MPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72316 seminal vesicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.366754 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29342 gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.932275 CDCP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31721 TRMT61A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79567 MEGF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71248 PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SHP-77 COSMIC Cell Line Gene Mutation Profiles 1.0 null Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMS53 CCLE Cell Line Gene Expression Profiles -1.0 -1.50095 ubiquitin-like protein peptidase activity GO Molecular Function Annotations 2025 1.0 null testis GeneRIF Biological Term Annotations 1.0 null Outer dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.761 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 142.553 SP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.841127 GSE200673,GSE200691_2_v_0_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PAX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17526 CCDC22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28801 STEEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31272 Brain Lower Grade Glioma_LGG_TCGA-CS-5395-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Post-translational protein modification Reactome Pathways 2024 1.0 null FOXP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4714 ASCL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82826 HPCAL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01646 MMRN1 Pathway Commons Protein-Protein Interactions 1.0 null PDLIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83479 OCIMY7 CCLE Cell Line Gene CNV Profiles -1.0 -1.49392 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 cellular macromolecule catabolic process GO Biological Process Annotations 2015 1.0 null Condensed nuclear chromosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.427 PMC8831562__F3 PFOCR Pathway Figure Associations 2024 1.0 null GSE241701_4_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null FASTKD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64273 LYL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29617 Motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 RCBTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33828 Lung squamous cell carcinoma_LUSC_TCGA-77-8148-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LMCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19843 ZNF585B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70977 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ANKRD39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58987 PPFIA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50875 PNMA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73836 MOLP8 CCLE Cell Line Gene Expression Profiles 1.0 1.36094 496100355_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.91188 POU5F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52164 GSE126621,GSE126920_1_v_4_dppa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null TRIM68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10868 male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.15008 Perturb_13213_KO_Yap1_SRP059253 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.48767 ZNF687 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84001 DDX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.30875 CSNK1A1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00626 CRB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29215 GSE145639_7_v_2_adar_human RummaGEO Gene Perturbation Signatures -1.0 null Synaptonemal complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.504 nucleus GO Cellular Component Annotations 2015 1.0 null HOXD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57247 LHX1_KO_GDS2748_298_mouse_embryonic renal vesicles GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7250-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.85505 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null STX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84735 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.27 CCDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49954 UNC93B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11127 sertoli cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.711729 TSFM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29092 mRNA_GADD45A_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null inguinal GeneRIF Biological Term Annotations 1.0 null C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17342 PMC7862630__F3 PFOCR Pathway Figure Associations 2023 1.0 null PRDM14 ChEA Transcription Factor Targets 1.0 null MT-CYB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9444 Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.426 POU2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4267 SOX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4649 PIK3C2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1175 SNX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69649 CCDC34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49689 CGREF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92742 Perturb_5192_KO_Nanog_SRP116119 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 SKG-IIIA COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE113267_0_v_1_rfx7_mouse RummaGEO Gene Perturbation Signatures 1.0 null NUDT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.70334 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1116 CCK-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZBTB20_Deficiency_GDS3718_517_mouse_Developing hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null effect GeneRIF Biological Term Annotations 1.0 null PCGF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87188 Flagellate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.123 Acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.568 PBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61513 JAK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05473 anteroventral nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.895118 Ebolavirus(ZEBOV)_3day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.94432 Peritubular contractile cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.376 dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.00177 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54159 Esophagus - Gastroesophageal Junction GTEx Tissue Gene Expression Profiles 2023 1.0 7.21239 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.919 EHMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87654 CPSF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39563 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08067 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.943882 FOXS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35934 OPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53061 Rectum adenocarcinoma_READ_TCGA-DC-6683-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A6YR-01A-33R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32565 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6471-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.76094 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.552 SMG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30763 SIMA CCLE Cell Line Gene Expression Profiles -1.0 -1.63769 NUGC2 CCLE Cell Line Gene Expression Profiles -1.0 -2.31988 HOXA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21519 intracellular part GO Cellular Component Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OLFML2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90726 HSP90AB1 Pathway Commons Protein-Protein Interactions 1.0 null ZNF529 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3817 Supporting cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.674 PAX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39549 GSE118765_1_v_5_rreb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null exert GeneRIF Biological Term Annotations 1.0 null Vomeronasal nerve TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.533 HOXB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2328 Perturb_5056_OE_MERVL_SRP161512 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 ITGB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9817 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52638 CAPAN-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.53 SOX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.6693 H6PD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65759 sperm flagellum GO Cellular Component Annotations 2025 1.0 null HCaRG_OE_GDS2426_711_human_HEK293 kidney cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MRPS23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88304 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.990822 GSE185881,GSE185884_2_v_3_ctcf_mouse RummaGEO Gene Perturbation Signatures -1.0 null LIPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47235 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3380-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMAD protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.146 Sperm midpiece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.367 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP1R16B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00698 GSE210476_2_v_7_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null RASGEF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98537 IGF2R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73669 Water HMDB Metabolites of Enzymes 1.0 null POU4F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1119 Triclosan_NCI-H661 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0102787 FOXC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9445 ZFYVE21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66764 MAPKAPK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26128 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.82632 ESX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64955 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70853 SAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08863 PMC2809080-1471-2164-10-637.nxml--Missing_DUB_Genes_Protein_in_Zebrafish_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.196 known GeneRIF Biological Term Annotations 1.0 null USP36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18696 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.648928 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HOXD12::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4 dorsolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.95866 SCN4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23891 NCK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14948 DBH_KO_GSE33906_53_mouse_heart (E10.5) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NCIH2291 DepMap CRISPR Gene Dependency 1.0 2.68117 GSE217363_5_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null cellonly GeneRIF Biological Term Annotations 1.0 null Ub-specific processing proteases Reactome Pathways 2024 1.0 null TMEM200C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25824 EIF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45553 GSK3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40894 VPS36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14611 cysteine-type peptidase activity GO Molecular Function Annotations 2015 1.0 null cysteine-type deubiquitinase activity GO Molecular Function Annotations 2023 1.0 null PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR Rummagene Transcription Factor Associations 2026 1.0 null NCKAP5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86744 C1orf52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51266 GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC2840217__F9 PFOCR Pathway Figure Associations 2023 1.0 null Spermatozoon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.496 GSE238018_3_v_0_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null IGF2BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12623 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.161 JHH-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null count GeneRIF Biological Term Annotations 1.0 null hippocampus (hippocampal formation)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.82028 PMC8329168-41418_2021_763_MOESM8_ESM.docx-0-DUB_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null GSE196671_5_v_8_obox4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE130690,GSE130692_2_v_0_sirt6_mouse RummaGEO Gene Perturbation Signatures 1.0 null MIB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6094 ZHX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04641 PBX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32791 ADPGK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0636 Sex chromatin COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.571 Tonne-Kalscheuer syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.243 decreased circulating testosterone level MGI Mouse Phenotype Associations 2023 1.0 null KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974525 JHOS2 CCLE Cell Line Gene CNV Profiles 1.0 1.90567 SULT4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11833 METTL7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95019 SUMO-targeted ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.758 GNPDA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66227 SC-12738 (CSNK2A1) NURSA Protein Complexes 1.0 null integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054811 MEF2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.2459 FHIP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29821 Autosomal dominant cerebellar ataxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.686 LAMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.59931 RLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55566 NCI-H1048 COSMIC Cell Line Gene Mutation Profiles 1.0 null LU134A DepMap CRISPR Gene Dependency 1.0 3.46085 496100520_HIP_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.46968 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CK-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02418 fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CLEC14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26651 HIPK2_defectivemutant_29_GDS4233 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.32362 SK-MEL-31 COSMIC Cell Line Gene Mutation Profiles 1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.277 sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.549312 TFIP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81218 PANC0327 DepMap CRISPR Gene Dependency 1.0 2.2426 KNS-81-FD COSMIC Cell Line Gene Mutation Profiles 1.0 null serves GeneRIF Biological Term Annotations 1.0 null HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15186 PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX Rummagene Transcription Factor Associations 2026 1.0 null present GeneRIF Biological Term Annotations 1.0 null PACADD188 DepMap CRISPR Gene Dependency 1.0 2.35199 Glioblastoma DisGeNET Gene-Disease Associations 1.0 null MKI67 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72482 VIPAS39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30656 DDX60L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02813 IRF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4517 YJEFN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10445 JUP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68334 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.55642 hypogonadism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.388538 BHT101 CCLE Cell Line Gene CNV Profiles 1.0 1.72358 Oligospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.034 EEF1E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30046 RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null XRCC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60602 asian GeneRIF Biological Term Annotations 1.0 null TPMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57224 OAZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95715 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-AAVH-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Non-Obstructive Azoospermia DisGeNET Gene-Disease Associations 1.0 null interstitial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.50275 GTF3C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27904 POU3F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7661 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RKN COSMIC Cell Line Gene CNV Profiles -1.0 -3.7119 secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.19579 IZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14682 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.826242 MC116 COSMIC Cell Line Gene Mutation Profiles 1.0 null HUO9 DepMap CRISPR Gene Dependency 1.0 3.39122 CSTB_KO_GDS5090_199_mouse_Cerebellum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE198165,GSE198166_5_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null ADAMTS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47517 GSE84922,GSE84924_0_v_1_sall4_mouse RummaGEO Gene Perturbation Signatures -1.0 null BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.78711 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.50774 CAOV3 CCLE Cell Line Gene Expression Profiles -1.0 -1.97499 ZNF677 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7862 outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37634 Cerebellar ataxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.532 PMC8119428-41598_2021_89734_MOESM6_ESM.xlsx-Sheet1-Candidate_PORE_genes_potentially_bound_and_regulated_by_OCT4_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null EXD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08678 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21306 ZNF45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38324 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.918905 LAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90139 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RW-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMRTC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -5.04885 FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.1789 PLTP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00779 macromolecule catabolic process GO Biological Process Annotations 2015 1.0 null Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.323