association	dataset	threshold value	standardized value
r8 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08709
Sarcoma_SARC_TCGA-DX-A23Z-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4576_KO_Haspin_SRP271373	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.78619
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48141
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57211
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053948
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hypertropia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
BRD-K23203419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15649
GSE179002_4_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H358	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
modification-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
increased startle reflex	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K61416283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18528
ZIC3-20872845-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87990527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43847
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.56555
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K54872884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03074
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26904
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05905
BRD-K38750802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31857
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.26542
AKAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98222
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27363274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26481
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JT-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09232
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GAP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81913
periventricular stratum of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09772
496100332_HIP_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.6858
PHF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96225
proteolysis involved in cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K65107903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89817
external part of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01272
BRD-K20071915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91225
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.594476
GATA1	ENCODE Transcription Factor Targets	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.85349
posterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15073
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83503
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60781525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20294
Clear cell renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
positive regulation of cytokine-mediated signaling pathway	GO Biological Process Annotations 2023	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	1.10655
icSARS CoV_12Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.69528
MES-SA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
neuroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224398
ChIP_ZIC3_20872845	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22655
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43U-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01405
Fanconi anaemia nuclear complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.555
Nucleus of the solitary tract, commissural part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1532
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3HZ-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92022897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73687
GSE131161_2_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.49167
GSE200673,GSE200691_1_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tonne-Kalscheuer syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.698
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04085
Lung adenocarcinoma_LUAD_TCGA-75-6203-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09878843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57975
OPM-2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.99389
Purkinje cell layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13297
BRD-K09108485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90407
H3K27me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76664579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67508
periventricular stratum of r3Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56913
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08687
HDAC1_KO_GDS2294_67_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02903
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VH-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.346
paraventricular nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19094
SK-N-AS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.718
ID1_01_117	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.06722
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08075
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82718
GSE222758_0_v_2_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71806
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.80571
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH2227	CCLE Cell Line Gene CNV Profiles	1.0	2.2853
Perturb_16360_OE_Ppargc1a_SRP278337	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BL70	CCLE Cell Line Gene Expression Profiles	1.0	2.65275
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10221
pituitary	GTEx Tissue Gene Expression Profiles	-1.0	-1.38034
SNU878	CCLE Cell Line Gene CNV Profiles	1.0	1.62427
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05024
PMC11233972-mmc1.pdf-3-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH322	CCLE Cell Line Gene Expression Profiles	1.0	1.92644
CALU6	DepMap CRISPR Gene Dependency	1.0	2.75387
BRD-K73095160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34911
BRD-K57359365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86891
HIPK1_knockout_170_GSE39253	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.691537
r4 part of medial paralemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26957
DDHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67607
OMC-1	GDSC Cell Line Gene Expression Profiles	1.0	1.48789
BRD-K89701103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1855
GSE157960_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89716
hsa-miR-548p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
APPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92487
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.84013
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.62583
MEL-JUSO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46716
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.30817
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.986294
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929381
BRD-K93040255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29148
SAGA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.0
oral mucosa	HPA Tissue Protein Expression Profiles	-1.0	-1.22643
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41176
HS-683 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
HUNS1	CCLE Cell Line Gene Expression Profiles	1.0	1.58963
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074326
PANC0203	DepMap CRISPR Gene Dependency	1.0	2.29576
cell cycle G1/S phase transition	GO Biological Process Annotations 2025	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70D-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A86F-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.15732
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03636
Perturb_5307_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP101434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.21972
HL-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GATA2-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EFE184	CCLE Cell Line Gene Expression Profiles	1.0	1.64923
8MGBA	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.06023
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
LN18	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52822
15750623-Table1	GeneSigDB Published Gene Signatures	1.0	null
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2513
H3K9me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.1702
BRD-A98714080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.384
ovary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.830209
STAT3_OE_GDS3444_576_mouse_Cultured embryonic stem (ES) cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
EP300-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11499
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30699866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2118
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9503
GSE218580_1_v_0_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K25895238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24248
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
RMG-II cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.924
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11078
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19009697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55509
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07256
Perturb_17361_Mut_Sik3E13_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.03062
H3K9me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6356
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.949068
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2809080-1471-2164-10-637.nxml--Missing_DUB_Genes_Protein_in_Zebrafish_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
EP300-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K15123815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39159
PMC5727433-41467_2017_2029_MOESM3_ESM.xls-Sheet1-Supplementary_Data_1_DUB_shRNA_list_used_in_this_study_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.5555
BRD-K80469338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33571
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.9148
laudanosine-1741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35869
ZMYM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43939
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60795
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86953192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08251
r2 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38699
Proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.904
SNU119	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50807
benzbromarone-6669	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82126187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05853
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE138001_0_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80L-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neuropeptide-S nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29101
SW982	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K49733809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0244
Testis	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.1465
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8404_KD_Cebpb_SRP312780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
r6 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06539
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2723
furafylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38588
HK-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05985
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52148
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03434
Perturb_15061_OE_Trp53_SRP345823	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.6915
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6035
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5661
Cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44365
BRD-K84054400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06169
BRD-K56373119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03242
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QD-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-769-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K37763427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23656
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.64376
hsa-miR-4324	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K44799944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30587
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Gracile nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.07023
Sarcoma_SARC_TCGA-DX-A6YR-01A-33R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.98061
vagina	HPA Tissue Protein Expression Profiles	-1.0	-1.22643
GSE174751_0_v_1_postn_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100495_FWM_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.3263
decreased prepulse inhibition	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K02793474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05597
Abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10054
GNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50999
nucleus	GO Cellular Component Annotations 2025	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HT-29	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Paraventricular hypothalamic nucleus, magnocellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01767
BRD-A19962819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20727
BRD-K06408981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48568
morula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071306
BRD-K22974051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2916
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10843
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37328
BRD-K68617666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31719
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34026
MFE319	CCLE Cell Line Gene Expression Profiles	1.0	1.58344
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.999452
BRD-K56470219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85128
GATA1_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
TEKTIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02369
BICR31	CCLE Cell Line Gene CNV Profiles	1.0	2.44346
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HCC1395	COSMIC Cell Line Gene Mutation Profiles	1.0	null
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36113
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	1.79233
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A0TN-01A-21R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A822-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
BRD-K17675814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.77596
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98059
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43462
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
dorsal part of m2A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09509
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.502
BRD-A75421526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65582
GSE211744_8_v_1_gdf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.913344
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KOC-7C cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.173
periventricular stratum of r7Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07918
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A81879813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56372
t64-ovaries_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.80414
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8061
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84836394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72259
MHHES1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.60712
ciclacillin-3882	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spiramycin-2558	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K80000073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05426
hsa-miR-3679-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SALL4-18804426-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
protein K48-linked deubiquitination	GO Biological Process Annotations 2023	1.0	null
HEKTE	CCLE Cell Line Gene Expression Profiles	-1.0	-2.9639
ECC12	CCLE Cell Line Gene CNV Profiles	1.0	1.45279
Superior olivary complex, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32099
BRD-K71836501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44836
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
mRNA_SMAD7_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.97377
CRCGN010_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31781
REST	ENCODE Transcription Factor Targets	1.0	null
HCC-827	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K24554824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14042
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7176
intermediate stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3214
BRD-K23366960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21256
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11399095-44161_2024_532_MOESM14_ESM.xlsx-Sheet1-Supplementary_Table_13_DEG_in_the_AA_borderzone_in_AF_vs_SR_patients_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_MYOD1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.891189
MOGGUVW	DepMap CRISPR Gene Dependency	1.0	5.79728
BRD-K30013451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03944
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
deubiquitinase activity	GO Molecular Function Annotations 2025	1.0	null
Perturb_5094_KO_Cbx1_SRP104194	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.80841
Vomeronasal organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.281
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.919553
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1200	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60795
SKLU1	CCLE Cell Line Gene Expression Profiles	1.0	1.35662
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.42435
periventricular stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47443
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16473
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.98061
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.34025
Simple lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2555
intermediate stratum of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07918
BRD-K80424876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35492
CCND1	ChEA Transcription Factor Targets	1.0	null
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.0611
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4843-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.64622
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07539
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
corticosterone-4145	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
N-nitrosomorpholine	CTD Gene-Chemical Interactions	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21306
BRD-K91624805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31362
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19946
PMC4621929__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K55505527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28046
PMC9225015-elife-72879-supp1.xlsx-DUB_CRISPR_library-Unnamed_3_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K63584084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48131
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71E-01A-31R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61483
YAP1-20516196-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.28148
GSE228894_3_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08688
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74368
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.893916
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0695
proglumide-2363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QX-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75293299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52283
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08687
Replication fork protection complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
BRD-K87530935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37507
BRD-K19734887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1446
RMUGS	CCLE Cell Line Gene CNV Profiles	1.0	1.57122
Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69840402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22214
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K40276277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09829
H3K9me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAD21	ChEA Transcription Factor Targets	1.0	null
OVCA420	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE180951_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37094
etoposide-6681	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A70931301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95638
positive regulation of cytokine-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
GSE206870,GSE206872_3_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiomyopathy, Dilated_Myocardial tissue_GSE3586	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.53154
BIM-BCL-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.555
TT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60918
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09785
HSC2	CCLE Cell Line Gene Expression Profiles	1.0	1.58933
orlistat-6383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A90450579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08309
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K66327237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39747
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
MBT-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.814
NCIH1581	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35258
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4710-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.68704
AIRE_KO_GDS2274_246_mouse_Medullary thymic epithelial cells (with high CD80 expression)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
periventricular stratum of r8Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08709
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5676
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K57643011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04113
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35291
positive regulation of type I interferon-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.67558
Major island of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00534
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.911549
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of proteolysis involved in cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
NCIH1781	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45394
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25965
regulation of protein catabolic process	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8090-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.3067
TEAD4	ChEA Transcription Factor Targets	1.0	null
increased anxiety-related response	IMPC Knockout Mouse Phenotypes	1.0	null
KMRC1	DepMap CRISPR Gene Dependency	1.0	3.63408
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
natamycin-6126	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VZ in postamygdaloid region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.03221
BRD-K92374432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18422
A3KAW	CCLE Cell Line Gene Expression Profiles	1.0	1.5317
GSE210476_2_v_1_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5735185-41467_2017_1200_MOESM4_ESM.xlsx-Table_S1-Choi_et_al_2016_DUX4_up-regulated_targets_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50204
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pirinixic acid-464	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03489
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.13165
SKNFI	CCLE Cell Line Gene CNV Profiles	-1.0	-2.27694
Perturb_13049_KD_H19_SRP063608	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.80473
clomipramine-3182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
eldeline-3750	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.36626
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1917
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.937
BRD-K18268126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30999
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
terminal nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61569
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900668
ESO26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.98061
RL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80732
GSE130081,GSE130082_0_v_10_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03348
BRD-K50191826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14921
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.39218
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	1.81141
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.43698
RAB6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3418
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.65718
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.32707
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.14218
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00596
ZFP42-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K35789946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30645
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72034681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71009
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058914
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IA-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1	ChEA Transcription Factor Targets	1.0	null
BRD-K16387460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38531
Perturb_12146_KD_Hdac4_SRP343455	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37496
BRD-K65875972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40172
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17065706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74509
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50909
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14763
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
prostate	HPA Tissue Protein Expression Profiles	-1.0	-1.22643
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LS123	CCLE Cell Line Gene CNV Profiles	1.0	1.36206
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.0055
Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
BRD-K44260904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40895
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13821
GSE147056_3_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
skeletal muscle	HPA Tissue Protein Expression Profiles	1.0	2.56275
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K55053106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43739
BRD-K76829357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04308
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.51715
NCIH929	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86575
Lung adenocarcinoma_LUAD_TCGA-93-8067-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
substantianigra	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.894652
intracellular part	GO Cellular Component Annotations 2015	1.0	null
BRD-K16468319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05237
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
496100569_TCx_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.3605
SKNDZ	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51859
BRD-K38519585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21069
BRD-K69074358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77235
mRNA_ASCL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.537812
Endodeoxyribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.931
HGC-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.1775
nifuroxazide-2490	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10746
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13369
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18296568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26226
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
LIMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66711
SNU449	CCLE Cell Line Gene Expression Profiles	1.0	1.77908
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZL-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cyclin D2-CDK4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.591
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNU423	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45802
BRD-K00767817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78827
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.37197
16484322-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
beta-TC3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
A-Netherlands-602-2009(H1N1)_3Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.79206
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K54456668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02474
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837191
BRD-K21036759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64838
RL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97028
BRD-K47878187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06451
BRD-K92431275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54642
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.00399
Perturb_5344_KO_Ilf2_SRP100469	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.80308
BRD-K44121468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81731
Dorsal premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.96293
BRD-K02241673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63466
BRD-K99755021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10117
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219707
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73336
BRD-K64132098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31668
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.632
SUM-159PT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.605
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25612
BRD-K30173809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27281
BRD-K43108627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07205
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.712857
LU-165	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
sirolimus-402	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837191
CBX3	ENCODE Transcription Factor Targets	1.0	null
regulation of type I interferon-mediated signaling pathway	GO Biological Process Annotations 2025	1.0	null
XRCC2-RAD51D complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
carboplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0488
BRD-K50859531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30061
defense response to virus	GO Biological Process Annotations 2025	1.0	null
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.04557
pentolonium-3676	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JURKAT	CCLE Cell Line Gene Expression Profiles	-1.0	-2.79734
19621087-Table1e	GeneSigDB Published Gene Signatures	1.0	null
regulation of cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.38596
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60819
modification-dependent macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.91222
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
Perturb_9778_KD_Gas41_SRP110498	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.3603
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21974
r2 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46371
Perturb_3452_KO_Plp1_SRP073495	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.99827
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48326
MAC2A	DepMap CRISPR Gene Dependency	1.0	3.57551
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.4785
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.53662
496100519_HIP_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09167
NR1I2-20693526-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Tcf1_KO_GDS1473_307_mouse_Pancreatic islets	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K29802952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19815
Perturb_5861_KD_H3f3a_SRP133189	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.93225
organelle	GO Cellular Component Annotations 2015	1.0	null
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15795
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14171
Dopaminergic A13 group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54649
BRD-K18623962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50753
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13702
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41176
GATA1_G1E-ER4_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18407
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.833186
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5064
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A6BH-01A-12R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.344079
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.270909
BRD-K90284572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18094
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58035
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1948
BRD-K42333498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11622
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.58005
regulation of type I interferon-mediated signaling pathway	GO Biological Process Annotations 2023	1.0	null
RKO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.66551
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r8Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94293
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31921
BRD-K35413741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05051
Hemispheric regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08576
azaperone-6151	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9302
parastrial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.16428
thyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-1.22643
BRD-K70980943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20466
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
G1/S transition of mitotic cell cycle	GO Biological Process Annotations 2025	1.0	null
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43654313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21154
AR-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K02624294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15954
WDR5-24793694-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DOK	DepMap CRISPR Gene Dependency	1.0	2.35699
BRD-A94740628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22276
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.941717
BRD-K80851151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43368
PAS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.281
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.27971
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20755
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3799
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.856072
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9585
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3902
lateral spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05533
BRD-K34695725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01125
Zona reticulata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
GSE179002_0_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A702-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16836
decreased exploration in new environment	IMPC Knockout Mouse Phenotypes	1.0	null
Perturb_14039_KO_Dnmt1/Dnmt3a/Dnmt3b/Creb1_SRP337936	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.74097
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
neuro-2a cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.725685
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08308
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39608
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.60569
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of innate immune response	GO Biological Process Annotations 2023	1.0	null
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LNZTA3WT4	DepMap CRISPR Gene Dependency	1.0	2.98884
stachydrine-4469	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13766
SETDB1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22655
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.3639
SK-OV-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Ubiquitin specific protease, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Type 1 diabetes mellitus_pancreatic islet_GSE2254	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.49262
Perturb_5020_Mut_Sall4_ERP122174	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.99878
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.880554
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8334-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36691
NCIH3255	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71822
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
ZFP42-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K00377328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98504
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.846632
SMARCA4	ChEA Transcription Factor Targets	1.0	null
r8 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94948
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.552993
SNUC1	DepMap CRISPR Gene Dependency	1.0	3.5086
PMC12481283-bmb-58-9-371.nxml-Table_1-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09509
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thioproperazine-5791	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_16084_KO_Nfya_SRP270915	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.57606
Becker	GDSC Cell Line Gene Expression Profiles	-1.0	-2.86575
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052413
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFK_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perireunensis nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18509
SH-EP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.92
ZIC3-20872845-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15746
BRD-K61087440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9067
FOXA1_OE_GDS4957_10_human_LNCaP prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3763
BRD-K13267130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34407
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
BRD-K53896147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40746
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052898
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09232
PMC8526018-KAUP_A_1856493_SM1378.xlsx-Table_S5-_DUB_genes-Table_S5_Compared_deubiquitinating_enzyme_genes_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10595
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21306
BRD-K26395018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22404
CAL-62	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69092
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.728
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37527
BRD-K75038426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00922
periventricular stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10333
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21306
increased anxiety-related response	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.39109
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04441
outer SZ in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30017
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.62205
A172	CCLE Cell Line Gene CNV Profiles	1.0	1.35563
BRD-K63743653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85537
SP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.959399
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12224
BRD-K13839731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5682
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
inner CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.971782
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.1747
BRD-K66802550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28544
BRD-K98408574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10274
HUO9	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.98061
mantle zone of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38819
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08687
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.57132
Perturb_13187_OE_Cry2_SRP303502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.06185
GSE179002_0_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21306
Bed nuclei of the stria terminalis, posterior division, interfascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02988
fetal membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308974
UAP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58096
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4957
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71622214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69364
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A1QS-01A-61R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r4BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01396
BRD-K78886448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4409
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
clopidol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0722
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.464
BRD-K53443314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3364
subcuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.03109
ATM_Deficiency_GDS1544_769_mouse_Lymph nodes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K73830970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03928
PMC8542838__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K79494396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07499
BRD-K86019347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1168
BRD-K73802986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46511
FOXO1	ChEA Transcription Factor Targets	1.0	null
hsa-miR-4284	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
HCC202	CCLE Cell Line Gene CNV Profiles	1.0	2.30114
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COV318	CCLE Cell Line Gene Expression Profiles	1.0	3.40647
NCI-H69	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37877
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.959223
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70K-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23355
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.30078
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
tolfenamic acid-5454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prestwick-1100-4534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF100_01_124	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58552
frontal operculum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36943
BRD-K69387464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09151
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4258
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70644
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.29654
UBQLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80959
Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06047
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1876	CCLE Cell Line Gene CNV Profiles	1.0	1.54932
Amnion epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00732
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
BRD-K28764680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36903
r3 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34279
defense response to symbiont	GO Biological Process Annotations 2023	1.0	null
BRD-K59560948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47906
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.90918
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98059
protein deubiquitination	GO Biological Process Annotations 2015	1.0	null
Extraembryonic tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.922
Parasubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11302
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29122
BRD-K37285826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35524
Perturb_226_KD_TPRX1/TPRX2/TPRXL_SRP361145	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.53445
parahippocampal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.928474
BRD-K89325755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45473
GSE138001_0_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
decreased birth weight	MGI Mouse Phenotype Associations 2023	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1847
metamizole sodium-3929	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12175788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57285
tolmetin-4167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXO1-23066095-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Facial motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04772
hsa-miR-29b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Perturb_13216_KO_Dnmt3b_SRP063529	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
fluvastatin-3032	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
BRD-K65108634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05086
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840556
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZN-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20621
hsa-miR-601	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49275
ZIC3	ChEA Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RI-11A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07383982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46019
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CFTR_Deficiency_GDS1843_192_mouse_Lungs - Animals examined at 6 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7591-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YAP1-20516196-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.54925
BRD-K01314849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83607
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95576
Lung adenocarcinoma_LUAD_TCGA-44-2661-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193588_3_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.924622
hsa-miR-4793-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
isosorbide-4742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.884269
NCIH1436	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56872
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83V-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
p2 portion of the parabrachial pigmented nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10054
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09129
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
gramine-3999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.81164
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31921
m1AD (DM) part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05024
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DMS-53	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90148
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058497
protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
B-CPAP	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.85356
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
BRISC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.488
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4889-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-410	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
hsa-miR-199a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Cytoplasmic ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.908
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DNA recombinase mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.709
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12347
BRD-K78615842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81159
PMC7910580-41467_2021_21715_MOESM3_ESM.xlsx-DUBs_screen-Supplementary_Data_1_Results_of_DUB_shRNA_screen_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EG-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61815
mantle zone of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13638
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09785
BRD-K09337184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22086
Perturb_4818_KO_Neil2_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.81365
flavoxate-2373	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56691
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
cysteine-type peptidase activity	GO Molecular Function Annotations 2015	1.0	null
Parasolitary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54649
JHH-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.62011
KMS26	CCLE Cell Line Gene Expression Profiles	1.0	2.18225
hsa-miR-2114	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K84745303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58045
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Superior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08297
CEBPB-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12441
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7236
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.981
PMC4521181-oncsis201520x8.pdf-16-ZNF292_ZNF292	Rummagene Transcription Factor Associations 2026	1.0	null
paternal effect	MGI Mouse Phenotype Associations 2023	1.0	null
inferior frontal gyrus, opercular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.77277
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84717
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885328
hsa-miR-29a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7883
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2237_KO_Malat1_SRP193997	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.51839
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15856
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.53936
egg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.314772
mitotic cell cycle phase transition	GO Biological Process Annotations 2023	1.0	null
BRD-K35209334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12515
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.947652
seminal vesicle	HPA Tissue Protein Expression Profiles	-1.0	-1.22643
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3637405__F2	PFOCR Pathway Figure Associations 2024	1.0	null
protein deubiquitination	GO Biological Process Annotations 2025	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19168437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.62623
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1041
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.851449
Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KARPAS-422	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17933
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K09975370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17943
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
deubiquitinase activity	GO Molecular Function Annotations 2023	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
PMC10315050-12920_2023_1588_MOESM2_ESM.pdf-18-ZNF223_ZNF223	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K96817767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77099
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80756
abnormal DNA methylation	MGI Mouse Phenotype Associations 2023	1.0	null
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.25935
ChIP_SETDB1_19884255	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
lateral part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02263
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L8-01A-21R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81A-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31236
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7505
dorsomedial preoptic area, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18216
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941127
G1/S transition of mitotic cell cycle	GO Biological Process Annotations 2023	1.0	null
CADM1_Deficiency_GDS2027_722_mouse_Testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
JVM-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.80088
Anterior hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30776
periventricular stratum of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00617
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22655
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885328
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10739
BRD-K40001806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94158
L-540	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60845
yolk sac	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.496874
anaphase-promoting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.388
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
Melanotroph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.983
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Machado-Joseph disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.903
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5011
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.32215
Perturb_13979_KO_Dnmt3a_SRP168393	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.5798
SET2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.06533
BRD-K77591784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8427
PMC11982601-IMM-175-84-s005.xlsx-Fig5D_LPS-Innate_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
hsa-miR-421	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GM2493	BioGPS Cell Line Gene Expression Profiles	1.0	0.98059
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16605
Familial combined hyperlipidaemia_Blood monocyte_GSE11393	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.5337
NCCSTCK140	CCLE Cell Line Gene CNV Profiles	1.0	1.44314
GM1600	BioGPS Cell Line Gene Expression Profiles	1.0	1.3671
BRD-K65005311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11034
Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VC-01A-23R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.272
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.898269
Transient neonatal diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
BRD-K03765511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99385
BRD-K49992772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33435
BRD-K94766933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44169
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
layer 3 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10164
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.302118
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
embryonic brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.7711
CADM1_KO_GDS2026_301_mouse_testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cysteine-type peptidase activity	GO Molecular Function Annotations 2025	1.0	null
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5557
MES-SA	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.9437
BRD-K94629607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40468
SOX2	ChEA Transcription Factor Targets	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
Flocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14975
CD24_Reduced expression_GDS1392_93_human_Bone Marrow	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
nucleus of the stria terminalis, medial division, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46634
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z3-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.859885
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A902-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP1R1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10454
nucleus of the stria terminalis, medial division, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47039
BRD-A57762296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21147
superficial stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06886
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4621929__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-A47166394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02558
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_4_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.55672
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.826719
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9848
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RNASEH2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11713
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13993
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.17244
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.619
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.42535
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09232
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3365-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1944 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
GATA1_G1E-ER4_mm9_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4860404-Table1.XLSX-MR_specific-Table_S1-9_DEGspecific_for_mouse_rat_SCI_at_1_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23459
BRD-K72050003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86517
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SW1990	DepMap CRISPR Gene Dependency	1.0	7.45089
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.91194
paraventricular nucleus, cap part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06309
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9598
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.67663
BRD-K45519638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31156
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.99948
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5201-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3756857-12013_2013_Article_9635.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
Water	HMDB Metabolites of Enzymes	1.0	null
CTSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67338
GSE142684_2_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW 1990	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64602
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.718
BRD-K39649723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.68591
GSE202603_0_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K29614616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47098
BRD-K51490301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95384
BRD-K13087600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17511
YAP1	ChEA Transcription Factor Targets	1.0	null
BRD-K30198800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87323
LOUCY	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69703
PMC8198665-ijms-22-05754.nxml--E3_Ligase_DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
NR1I2	ChEA Transcription Factor Targets	1.0	null
GSU	DepMap CRISPR Gene Dependency	1.0	2.80314
BRD-K78297750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3619
TEN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38362
baclofen-2036	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K88200990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62714
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.10295
pyramidal layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27131
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873914
RPE1SS6	DepMap CRISPR Gene Dependency	1.0	2.55122
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6942-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
peripeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05998
MZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.975587
BRD-K57315740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81675
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22655
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13766
BRD-A28153253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21436
BRD-K91039552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79559
CAPAN-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.04277
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
kidney	GTEx Tissue Gene Expression Profiles	-1.0	-1.38034
BRD-K84514454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04874
SNU601	CCLE Cell Line Gene CNV Profiles	1.0	1.86827
valproic acid-5600	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.407073
superficial stratum of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20732
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50909
Prelimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
TP53	ChEA Transcription Factor Targets	1.0	null
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51368
ZFX_KO_GDS2718_151_mouse_hematopoietic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE131377_4_v_2_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73878
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41176
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_2_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
Barrington's nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47836
c-MYC_KD_GDS2526_110_human_BT-474 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
496100469_TCx_no dementia_TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.76504
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03597
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.74618
ubiquitinyl hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9942
hsa-miR-4693-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EP300	ChEA Transcription Factor Targets	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
LY-294002-424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K79213964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93396
A253	GDSC Cell Line Gene Expression Profiles	-1.0	-2.40127
Perturb_5768_KO_Sip1/Nkx21_SRP010804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.9177
no-11	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.75012
BRD-K25638876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00348
GATA1_G1E-ER4_mm9_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
COLO741	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60786
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04316
SW156	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cysteine-type deubiquitinase activity	GO Molecular Function Annotations 2025	1.0	null
SMNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21312
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09785
BRD-K03902845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64827
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
isthmic roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00534
CRCGN015_MCF10A.TP53.M_24H:B06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22009
nizatidine-3047	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FLK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.976
hand	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.548517
SUM229PE	DepMap CRISPR Gene Dependency	1.0	4.62999
FAM83D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54705
AGS	CCLE Cell Line Gene CNV Profiles	1.0	1.42158
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41306
KARPAS299	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72615
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.3378
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.944313
arm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.492572
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATR-ATRIP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.575
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4718-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35562235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3694
cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17074
HCC1599	CCLE Cell Line Gene CNV Profiles	-1.0	-2.08783
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2235
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.912482
laterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35971
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.861784
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53601
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	1.14486
BRD-K06896230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90841
Adrenocortical carcinoma_ACC_TCGA-OR-A5KY-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.83011
hsa-miR-3663-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K01152687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49478
Neuro-2a cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.968
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29208
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.91226
peptidase activity, acting on l-amino acid peptides	GO Molecular Function Annotations 2015	1.0	null
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
protein stabilization	GO Biological Process Annotations 2023	1.0	null
OV56	CCLE Cell Line Gene Expression Profiles	1.0	2.35561
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21796
CRCGN017_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67703
496100368_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.18946
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.874945
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PI-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
succinylsulfathiazole-2166	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-53-7626-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
postcentral gyrus, right, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.908279
HCE4	DepMap CRISPR Gene Dependency	1.0	2.41713
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0434
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K39267096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74338
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20056
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ISL1-27105846-CHIP-SEQ-CPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.8623
SETDB1-19884255-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35573
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
HUH-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Supramammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35625
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8002-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_8C-MLX_3T3_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.90931
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.86875
BRD-K71221636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78664
SFTPC_KO_GDS4876_476_mouse_Lung Type II cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
pindolol-4496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1833	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71495
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SK-MEL-24	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K52175660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01254
regulation of proteolysis	GO Biological Process Annotations 2015	1.0	null
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50838
superficial stratum of r6Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16321
BRD-K46446437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08423
r2 liminal central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52861
chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.01554
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8948
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A172	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.67481
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26604
cefixime-4567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
BRD-K80225716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00764
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07405
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
Pars intermedia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
TE-11	GDSC Cell Line Gene Expression Profiles	1.0	2.43701
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
CEBPB-26923725-CHIP-SEQ-MESODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K45022385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32418
BRD-K44103530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.84415
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885328
BRD-K36643302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72709
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1789_KO_Irf8_SRP265303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.16394
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-848-ENSG00000197483_ZNF628	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23355
HS746T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27680690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35764
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-399-ZNF628_ZNF628	Rummagene Transcription Factor Associations 2026	1.0	null
19605494-TableS3	GeneSigDB Published Gene Signatures	1.0	null
sulfinpyrazone-3192	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lower basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06845
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6356
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.461
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54094
etamivan-7260	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90148
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915175
mepenzolate bromide-3829	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE103372_0_v_3_smad1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.65154
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6888
hsa-miR-149	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
docebenone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.686
BRD-K56408846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13671
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
eldeline-3925	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55142307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15333
GCIY	CCLE Cell Line Gene CNV Profiles	1.0	1.98545
KYSE-140	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_13409_KO_Zeb2_SRP066910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
SF268	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.767
BRD-K90527476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05747
OVMANA	DepMap CRISPR Gene Dependency	1.0	2.14897
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.86921
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6356
BRD-K80232129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89192
ZNF566	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4686
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24665
sulfinpyrazone-5753	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-7501-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A411-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31156
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1734
HT-3	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.98608
biological regulation	GO Biological Process Annotations 2015	1.0	null
GSE126127_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Beckwith-Wiedemann syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0156
lateral (dentate) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10957
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76485
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K83238251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21215
PMC12855127-Table1.xlsx-Sheet1-Table_S1_A_total_of_576_E3_genes_and_95_DUB_genes_were_identified_in_the_iUUCD_2_0_database_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE208254_4_v_1_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	1.36441
abnormal skin morphology	IMPC Knockout Mouse Phenotypes	1.0	null
TNKS_INHIBITION_GDS5029_280_human_SW480 KRAS-mutant colorectal cancer cell line - 4hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC5323140-oncotarget-07-65090-s002.xlsx-DUX4_ONLY-Gene_symbol_db2db_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A76K-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PFAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94744
Mesothelioma_MESO_TCGA-SC-A6LR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
SALL4	ChEA Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41991
2,6-dimethylpiperidine-4543	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21306
Perturb_5244_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP275780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.63091
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.33151
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.889382
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86407
Dermal dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.862
PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
CDCA7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61215
hsa-miR-205	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Perturb_9782_KD_Esrrb_SRP321923	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.2961
BLUE1	DepMap CRISPR Gene Dependency	1.0	2.06135
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superior temporal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.92327
18787207-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE206870,GSE206872_1_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1183
PPARG	ChEA Transcription Factor Targets	1.0	null
BRD-K40251180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8905
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08687
tiapride-3663	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71593
pimethixene-7468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04634
chlorprothixene-6692	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28294
mRNA_POU5F1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Lateral septal nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06845
decreased locomotor activity	IMPC Knockout Mouse Phenotypes	1.0	null
Perturb_5317_KD_Xpr1_ERP133250	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.882
hsa-miR-767-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
iopamidol-2732	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K57476701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36034
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE179002_3_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53662389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51891
BRD-K05977380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13834
Site of DNA damage	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.918
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25319
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.9988
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Site of double-strand break	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.815
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.85779
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	0.945589
thioridazine-422	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
layer 6b of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1204
regulation of catabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54995
KBM-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
rosiglitazone-369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14685
protein modification process	GO Biological Process Annotations 2015	1.0	null
BRD-K21284411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32271
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42453
JHOS-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K41645779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00212
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
BRD-K46298577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53362
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05526
BRD-K22508525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52509
BRD-A68175400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04912
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55427
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36331
primary auditory cortex (core)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06224
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r1 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04381
BRD-K56889360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27662
mebeverine-3193	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K9me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.91475
BRD-K50726251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14084
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32652
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.57345
BRD-K64862162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.082
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52975
MZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.463
BRCA1-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.472
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03348
ventrolateral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79334
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.75985
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34697
BRD-A11130173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31959
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
BRD-K19800225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13009
limb bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.592444
BRD-K33967077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49056
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
OMC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.958258
GATA1_G1E-ER4_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2037
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51682
SKM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43534
granular layer of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3422
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.15217
BRD-K57879743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15158
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.929001
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	0.995225
Lung adenocarcinoma_LUAD_TCGA-44-3396-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1187	DepMap CRISPR Gene Dependency	1.0	13.0486
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_4575_OE_Haspin_SRP271373	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.17271
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27476975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20965
BRD-K78009480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20158
BRD-K72707702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63402
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139948_3_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.5003
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13185
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.4563
VMRCLCD	CCLE Cell Line Gene Expression Profiles	-1.0	-2.09949
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DCA_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K84802956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56218
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0134
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79678951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39844
minocycline-2405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K61315077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1388
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SNU601	CCLE Cell Line Gene Expression Profiles	-1.0	-2.11182
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
lidocaine-4421	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
internal segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.95733
BRD-K13086002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44847
red nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.831113
r4 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56037
Lung adenocarcinoma_LUAD_TCGA-49-4505-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4753-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-AB2J-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF24_01_353	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.09535
BRD-K20203758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32144
GSE179002_3_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
NCI-H1734	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K12884811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34329
SOX2-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.49889
positive regulation of innate immune response	GO Biological Process Annotations 2025	1.0	null
BRD-K28785305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4596
BRD-K48053776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46231
Perturb_4568_KO_Prmt1_SRP178236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.25605
cingulate gyrus, retrosplenial part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16195
BRD-K16502264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46253
outer SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.830648
BRD-K88812218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25675
cysteine-type peptidase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K42145213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62396
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02456
BRD-K89436979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22128
BRD-K45272675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04094
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GN-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13792178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41046
BRD-K48299239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14621
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.14234
BRD-K97468369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07252
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56625
Lung adenocarcinoma_LUAD_TCGA-50-5932-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.51415
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1705
superior parietal lobule, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.865321
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39643
BRD-K83270266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27134
Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HS-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:I17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29785
BRD-K20733942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69397
brain	GTEx Tissue Gene Expression Profiles	1.0	1.48868
SLC30A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61338
H3K9me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K98976117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16213
posterobasal nucleus, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23343
levomepromazine-3701	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K89278382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30061
superficial stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08709
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5965
Paraventricular hypothalamic nucleus, descending division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53746
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15944
PHA-00745360-4384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LY2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.37412
nucleus	GO Cellular Component Annotations 2015	1.0	null
GSE138001_2_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.40265
SW1116	CCLE Cell Line Gene Expression Profiles	1.0	1.76866
hsa-miR-3121-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
carbarsone-4110	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.56301
A172	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
Flocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01062
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41176
NCIH2170	CCLE Cell Line Gene CNV Profiles	1.0	1.38226
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46953
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4941
perimammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13638
COLO-824	GDSC Cell Line Gene Expression Profiles	-1.0	-1.91341
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.45351
BRD-K20501114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0106
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1167
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98059
HCC2218	CCLE Cell Line Gene Expression Profiles	1.0	1.74905
dorsal periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13356
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85301
fipexide-3176	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Myc-Max complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.849
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Hepatic Cirrhosis_Liver_GSE6764	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.49298
acacetin-3942	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K44078665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70051
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.58309
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K28924192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1481
Perturb_11743_KD_Nsd2_SRP312884	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.73841
rosiglitazone-6192	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-386-PATZ1_PATZ1	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TH-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46371
BRD-K98529522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12174
r4 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83564
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.029
BRD-K75976016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00217
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35176
ChIP_H3K9me3_19884255_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6191
CA9-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.443731
JHU011	DepMap CRISPR Gene Dependency	1.0	2.38985
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
Extravillous cytotrophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.942686
BRD-K22748970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18423
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PCM6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74873
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6936-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K62541003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44252
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4576
Neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
SOX2-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
defense response to virus	GO Biological Process Annotations 2023	1.0	null
BRD-K40841951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02278
BRD-K45677957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24323
ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
ventral posterior lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.972082
upper basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24931
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39032
BRD-K20714346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40116
EEF1E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30046
POFUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62525
SK-NEP-1	GDSC Cell Line Gene Expression Profiles	1.0	1.63444
hsa-miR-4711-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.62105
carbenoxolone-4173	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IM95	DepMap CRISPR Gene Dependency	1.0	2.47115
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26604
hsa-miR-199b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
BRD-K82019575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56895
BRD-K73430970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00401
NCI-H1975 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.537
GSE157262,GSE157268_3_v_0_ythdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-29c	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.5385
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Flocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07682
ZNF274-21170338-K562-HELA	ChEA Transcription Factor Targets 2022	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885328
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77065
BRD-K59191599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06577
GK_KO_GDS2610_162_mouse_Brown adipose tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.927749
hsa-miR-4314	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.17018
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CAL-51	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49622
dexamethasone-374	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Dorsomedial nucleus of the hypothalamus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11681
BRD-K14399036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28601
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8721
proteasomal protein catabolic process	GO Biological Process Annotations 2015	1.0	null
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3309
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.029
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.35927
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.841053
SUMO-targeted ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
CL11	DepMap CRISPR Gene Dependency	1.0	9.54675
BRD-K23553911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2627
hsa-miR-576-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K60693111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.065
BRD-K95014129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27628
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00671
KP-2	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.50937
KLF7_KO_GDS2069_68_mouse_olfactory epithelia	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YJ-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100354_PCx_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21788
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88459
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6176
SALL4-18804426_ESC-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
cerebellar white matter	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00507
UCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27677
peduncular nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27157
posterior part of anterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39286
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67677
GATA1_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FADU	DepMap CRISPR Gene Dependency	1.0	2.66953
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51273
BRD-K07781811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35303
proteolysis	GO Biological Process Annotations 2015	1.0	null
Posterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3457
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MN-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE132759_4_v_5_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171401_1_v_0_adnp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03983
forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.261964
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5183-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCH	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.9823
BRD-K87541124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00541
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.72122
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03348
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74368
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.98061
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
increased startle reflex	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13022
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9212
A-498 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.6
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37413
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
spinal trigeminal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05028
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.53182
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04048
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
127399	DepMap CRISPR Gene Dependency	1.0	2.12723
NRL_Deficiency_GDS2936_630_mouse_Retinas - 10 days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A01717111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.09982
regulation of proteasomal protein catabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.33265
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1687
BSPRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82643
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.71965
ER ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.185
r9 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10054
KMS34	CCLE Cell Line Gene Expression Profiles	1.0	1.87202
BRD-K30792491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10884
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38877
YY1-21170310-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZFP42	ChEA Transcription Factor Targets	1.0	null
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07633
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53601
Ventral part of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10613
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
Proteasome core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.094
frontal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11663
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.98061
MBTPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45213
Perturb_5098_KO_Cbx5_SRP104194	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.82961
CP-320650-01-3908	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-544	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cellular macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-A38066207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4632
NFE2L2_KO_GDS514_699_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K84846130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21215
EB1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83763
hsa-miR-4803	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K74794014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18887
GSE131649_2_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dentate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20269
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7792
SW1990	COSMIC Cell Line Gene CNV Profiles	1.0	2.12225
Perturb_17277_KO_Kdm1a_SRP185978	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.78155
doxazosin-3024	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE139948_3_v_6_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
16484322-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43945
Skin Cutaneous Melanoma_SKCM_TCGA-HR-A5NC-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUGC2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0445
tamoxifen-375	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GB1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.51823
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K58596567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67369
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02451
Lung adenocarcinoma_LUAD_TCGA-44-6146-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EMC-BAC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8857
PMC4963401-fgene-07-00133.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48556518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05843
BRD-K13204142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09244
BRD-K36737730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23057
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83685
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TC-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRCA1-BARD1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.155
BRD-K79807180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23692
Perturb_16942_KO_Nurr1/Th1_SRP017560	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.51866
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81826
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0384
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00805
ST486	GDSC Cell Line Gene Expression Profiles	1.0	2.15324
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
mRNA editing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.945
lateral periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08709
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC2999557-pone.0015082.s014.xls-ZNF274_GeneInfo_M13_M11_M1-Gene_Symbol_ZNF274	Rummagene Transcription Factor Associations 2026	1.0	null
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
spinalcordupper	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.868511
periventricular stratum of r4Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3214
UMC-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2195
UPCISCC029A	DepMap CRISPR Gene Dependency	1.0	2.39979
BRD-K59744424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03845
BRD-K97064059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64911
PK59	CCLE Cell Line Gene CNV Profiles	1.0	1.52173
GSE174406_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LB-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABC1	CCLE Cell Line Gene CNV Profiles	1.0	1.38292
raloxifene-5759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09785
EEF1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72936
NCI-H1838 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.23
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45401
mRNA_MSC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
protein K48-linked deubiquitination	GO Biological Process Annotations 2025	1.0	null
Fanconi anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_3_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
valproic acid_homo sapiens_gpl96_gds1050	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K16304302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93543
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.156
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0034
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885328
H3K9me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.34568
PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.91323
GSE171401_1_v_2_adnp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A78982410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11903
superior rostral gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.857602
PMC8745310__F2	PFOCR Pathway Figure Associations 2024	1.0	null
lateral posterior nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.57046
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.36796
NCI-H650	GDSC Cell Line Gene Expression Profiles	1.0	1.73785
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.25392
GSE198165,GSE198166_8_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2349
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881487
BRD-K42797038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07055
BRD-K33767223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0931
BRD-K69080049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1893
496100288_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00346
shell of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85301
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.946465
cervix, uterine	HPA Tissue Protein Expression Profiles	-1.0	-1.22643
ubiquitin-like protein-specific protease activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5790-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.47129
SMAD3-22036565-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73715
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
GSE111660_1_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dorsomedial nucleus of the hypothalamus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66925
H3K27me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.4248
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.511
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22507
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K56884305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31075
BRD-K28803288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07358
BRD-K02190643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97393
PANC0203	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
BRD-K09250647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29873
hypothalamus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
Amnion epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.663
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4852-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44834268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21725
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZDHHC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32207
OVSAHO	CCLE Cell Line Gene CNV Profiles	-1.0	-2.44489
paraventricular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24293
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
PAX5_OE_GDS4978_548_human_L428-PAX5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.1783
Peptidase C19, ubiquitin carboxyl-terminal hydrolase	InterPro Predicted Protein Domain Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3M9-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Angelman syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
mantle zone of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34279
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SKOV3	BioGPS Cell Line Gene Expression Profiles	1.0	0.966557
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
pridinol-2715	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prasterone-3097	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC2840217__F9	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54E-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23711
KYSE-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76588804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73224
BRD-K02337960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49213
blastomere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070106
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16265
racecadotril-5755	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67015
protein catabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0287
NCI-H727	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K63997411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61073
Lung adenocarcinoma_LUAD_TCGA-55-8507-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78106941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08294
superficial stratum of RtC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27138
propofol-3048	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.57587
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8974
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.5745
intermediate periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31788
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09785
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51594
IST-SL1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JURLMK1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.99428
BRD-K60907484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.19645
BRD-K92613860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11947
BRD-K41946683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07132
BRD-K10684867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45362
Perturb_5054_KO_Adnp_SRP104194	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.08333
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZM-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5663
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873914
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078567
BRD-K14719962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09195
NCI-H838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LC-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.72588
POLR2AphosphoS5_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Extrachromosomal circular DNA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
r3 liminal central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57357
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46785
PMC12081856-41420_2025_2522_MOESM6_ESM.xlsx-Sheet_1-Table_S4_Complete_Gene_List_of_the_MEblack_Gene_Module_and_the_DUB_Family_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
PRPF38B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62085
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YK-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K23292451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83066
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38932
BRD-K31898235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.962
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.877667
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65313110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08852
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09788
cell part	GO Cellular Component Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2689-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	1.0	7.21237
CRCGN014_HEPG2_3H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35105
ZNF182	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81421
BRD-K99387963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18675
protein stabilization	GO Biological Process Annotations 2025	1.0	null
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.57547
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.977457
Perturb_5168_KO_Parp1_SRP064920	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38281
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13702
mantle zone of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56082
myclobutanil	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08166
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66086
PMC8542838-fimmu-12-742542.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61576
BRD-K73994499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39025
BRD-K59263278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23469
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98059
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08214
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.29494
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34969
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23703519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55899
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
NCI-H2347	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
peptidase activity	GO Molecular Function Annotations 2015	1.0	null
SETDB1-19884255-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0848
hsa-miR-3647-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
TAL1	ENCODE Transcription Factor Targets	1.0	null
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97083
BRD-K06425073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34168
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brn3a_KO_GDS1651_247_mouse_Embryonic (day 13.5) trigeminal ganglia - heterozygous	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K18635665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44754
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.3263
macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941127
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF274	ChEA Transcription Factor Targets	1.0	null
lateral posterior nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5645
Dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09767
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.64358
GSE94814_2_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54484
Sickle Cell Anemia_Endothelial cell_GSE9877	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.269383
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
Elongin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.592
benzethonium chloride-6070	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H250	COSMIC Cell Line Gene CNV Profiles	1.0	2.12225
GSE200320_1_v_0_mfge8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3I3-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20269
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24514
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12936
central part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05789
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23355
r6 part of ventral gigangocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19
RNA N6-methyladenosine methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.969
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1449
BRD-K29571884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04143
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-33	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.93163
Bed nuclei of the stria terminalis, anterior division, magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10054
BRD-K02837259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26117
PAX3-FKHR-20663909-RHABDOMYOSARCOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4361
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242054
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5742
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21990363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52635
AGS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K98510376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20438
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.31354
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12168
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08687
cortex of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20615
Simple lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31337
r9 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29425
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH28	CCLE Cell Line Gene Expression Profiles	1.0	1.37969
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
SMC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24677
Parastrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20594
UQCRFS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92574
CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Dorsomedial nucleus of the hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59679
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57507729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36635
CRCGN014_HEPG2_3H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46964
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16752
GATA1_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K9me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16376056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15823
BRD-K03035008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54215
EWS502	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83055
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.25888
BRD-M39894156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02478
PMC3637405__F2	PFOCR Pathway Figure Associations 2023	1.0	null
pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.805848
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.6713
BRD-K40809590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77661
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.763428
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein deubiquitination	GO Biological Process Annotations 2023	1.0	null
PECAPJ49	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50508
regulation of cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6975-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K46308702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08746
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4644-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53746
intermediate stratum of PHyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38529
T24	BioGPS Cell Line Gene Expression Profiles	1.0	0.945589
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
PMC11645450-MCO2-5-e70036.nxml-TABLE_1-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
protein modification by small protein removal	GO Biological Process Annotations 2023	1.0	null
YY1-21170310-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17285
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.54225
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
submammillothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87131
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36146
HL60	CCLE Cell Line Gene CNV Profiles	-1.0	-2.31456
BRD-K30943140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15736
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
ChIP_ZFP42_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00394
BRD-A08191729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37615
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT1376	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45114
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_17360_OE_HDAC4_SRP334442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.99311
blastocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315861
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
abnormal skin morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8301-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.723
paraventricular nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51144
cysteine-type endopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K73669270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71482
DMRT1	ChEA Transcription Factor Targets	1.0	null
gabapentin-7229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12826618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97241
SCABER	CCLE Cell Line Gene Expression Profiles	1.0	1.80683
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59968
cysteine-type deubiquitinase activity	GO Molecular Function Annotations 2023	1.0	null
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
cysteine-type endopeptidase activity	GO Molecular Function Annotations 2025	1.0	null
SUP-M2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r4 liminal central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3214
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
peduncular part of dorsomedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82315
mantle zone of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16963
blastula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071958
GSE123022,GSE123030_8_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63547380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44158
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2491
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00534
HCT-116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
subcallosal cingulate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.80291
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.377245
BRD-K79561909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56656
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6302
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.6715
BRD-K07589203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08361
BRD-K67665252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83252
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
dorsolateral preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03731
BRD-K92524632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34498
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.833186
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46444
GSE248858_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Supramammillary nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63494
NCIH1975	CCLE Cell Line Gene CNV Profiles	1.0	1.93405
JEG-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13505
TAL1-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.878333
BRD-K00620786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35132
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09785
CNE-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.253
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07807
Acute Myeloid Leukemia_LAML_TCGA-AB-2929-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKRC20	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84731
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00714
BRD-K49031847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40715
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100357_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17584
ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.805848
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09116
BRD-K94801143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11609
PEER	CCLE Cell Line Gene Expression Profiles	1.0	1.42214
496100556_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.64752
CRCGN015_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4284
OCI-LY7	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.96926
BRD-K90255725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01857
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4205
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116425
internal granular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20441
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
bcl11b_18199763_brain_lof_mouse_gpl1261_gds3178	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.049059
BRD-K79437066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8083
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1649
Subgeniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08018
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDE10A_KO_GDS4542_291_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.288514
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3286
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30776
SARS-BatSRBD_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.89741
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0166
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52609
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.351114
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988208
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9454
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09785
BRD-K72913973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05093
NCI-H1876	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K34858602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99754
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.921
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3971
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.82995
hsa-miR-1228	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
DSH1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC4860404-Table1.XLSX-MR_unique-Table_S1-7_DEG_unique_in_mouse_and_rat_SCI_at_1_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.909004
r2 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00563
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.98458
angelman syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.72684
BRD-K05335635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28272
BRD-K88478877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06595
GSE139975_3_v_1_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r7 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07648
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.16718
NCI-H64	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Subparafascicular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41151
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Posterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82917
BRD-A55408860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36696
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2840217__F9	PFOCR Pathway Figure Associations 2023	1.0	null
amnion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.503926
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
MNAT1_Deficiency - Ablation_GDS2561_689_mouse_Heart - 2 week old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.907093
GSE62974_1_v_0_epas1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KYSE-270	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K27824953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13262
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61967
proteasome-mediated ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
ubiquitin-specific protease activity	GO Molecular Function Annotations 2015	1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10160311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52509
GSE174586_0_v_1_slc4a11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100462_PCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.08276
decreased exploration in new environment	MGI Mouse Phenotype Associations 2023	1.0	null
PMC8329168-41418_2021_763_MOESM8_ESM.docx-0-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_5372_KD_MED13_SRP094120	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.52124
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
BRD-K20024676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02478
BRD-K90797575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02443
TCF4	ChEA Transcription Factor Targets	1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37998
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus of Barrington	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18509
GSE124471,GSE124488_1_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19F-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Secondary motor area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13416
Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56913
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EL-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K42966513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24341
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.89233
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.71378
finger	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.549312
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.31212
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5559-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885328
BRD-K95343362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81619
bed nucleus of the stria terminalis, medioseptal division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47443
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.57939
BRD-K89935890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44416
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.240826
positive regulation of type I interferon-mediated signaling pathway	GO Biological Process Annotations 2023	1.0	null
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A5KG-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Geniculate group, ventral thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05998
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.79032
RL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GATA1_G1E-ER4_mm9_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitotic cell cycle phase transition	GO Biological Process Annotations 2025	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03348
BRD-K64700664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11517
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05277
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900668
BRD-K83603369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30237
BRD-K14255526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26025
CRCGN014_HEPG2_3H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29927
BRD-K50129495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10331
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	2.44621
GCIY	COSMIC Cell Line Gene CNV Profiles	1.0	2.12225
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.2213
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00214
HSF1_01_155	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.99408
BRD-K45893504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22959
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03731
BRD-K53387776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50299
GSE126504_0_v_1_hpse_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.675
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.29989
496100560_PCx_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34745
BRD-A20731954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07428
BRD-K96510191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62367
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69347147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06539
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.321
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039841
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
aminoacyl-tRNA synthetase multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
sulmazole-4127	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
catabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.821
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05271
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
thalidomide-266	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.94746
H3K9me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.883058
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.9298
RD	GDSC Cell Line Gene Expression Profiles	-1.0	-1.45849
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70787
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57211
OVCAR4	CCLE Cell Line Gene CNV Profiles	1.0	2.11647
BRD-K52340217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25397
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EK-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.46221
Ribonuclease H2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.545
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0005
BRD-K77935284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42287
CTNNB1_Inactivation_GDS2984_628_mouse_Intestinal crypts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
FOXA1_OE_GDS4957_144_human_LNCaP prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GATA1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.41329
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057908
J82	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45133
IGF2BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12623
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A09115727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19994
GSE138818_1_v_3_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Plantar fascial fibromatosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.029
IGROV1	DepMap CRISPR Gene Dependency	1.0	8.45747
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73191
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1623	COSMIC Cell Line Gene CNV Profiles	1.0	2.12225
p3 portion of parabrachial pigmented nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33518
striohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12524
TE-10	GDSC Cell Line Gene Expression Profiles	-1.0	-1.41881
BRD-K87205390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18304
PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4648
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4326
Perturb_16359_OE_Ppargc1a_SRP278337	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.19151
Phagophore assembly site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
BRD-K47419679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20364
MSTO-211H	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.56976
PMC8120133-supplementarytables_ddab063.xlsx-Table_S2-Table_S2_Differentially_expressed_genes_in_DUX4-fl_and_DUX4-s_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5446900-NIHMS72240-supplement-Table_S1.xlsx-Table_S1-Table_S1_Genes_differentially_expressed_in_human_primary_myoblasts_upon_ectopic_expression_of_DUX4_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE248659_1_v_0_klf5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36228696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08217
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.27714
ChIP_SOX2_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
IPC298	CCLE Cell Line Gene CNV Profiles	1.0	1.37963
Cul2-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.693
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.978907
decreased prepulse inhibition	IMPC Knockout Mouse Phenotypes	1.0	null
superficial stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29425
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34876
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.927617
DU4475	DepMap CRISPR Gene Dependency	1.0	4.44072
P12ICHIKAWA	CCLE Cell Line Gene CNV Profiles	1.0	1.50085
SEC11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11401
CAOV4	CCLE Cell Line Gene Expression Profiles	1.0	1.35215
CLSPN	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A78T-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Familial erythrocytosis 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
MDAMB157	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93073
lateral orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24049
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
inner SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10563
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.45197
KYSE-70	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6356
Lung adenocarcinoma_LUAD_TCGA-73-4670-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
jf1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
FOXO1-23066095-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2266
BRD-K05584347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2357
ChIP_SALL4_18804426	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PAX3-FKHR-20663909-RHABDOMYOSARCOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cervix uteri	GTEx Tissue Gene Expression Profiles	1.0	1.30582
BRD-K58432332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05428
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.75299
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.029
BRD-K86677819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75313
trichostatin A-4436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4787-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
RI1	CCLE Cell Line Gene CNV Profiles	1.0	1.70285
BRCA1-B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.545
fluspirilene-3086	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
P12ICHIKAWA	CCLE Cell Line Gene Expression Profiles	1.0	1.68756
hsa-miR-4709-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
SNU213	DepMap CRISPR Gene Dependency	1.0	2.13774
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26511
BRD-K73579545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02904
Perturb_6208_KD_Zcchc8_SRP187429	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.85029
vestibular nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16135
Superior olivary complex, periolivary region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11586
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81
ST486	CCLE Cell Line Gene Expression Profiles	1.0	1.70487
YKG-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.55249
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885328
dexamethasone_homo sapiens_gpl6244_gse20963	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SC-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.7201
PMC3064265-NIHMS252278-supplement-3.xls-A_Interactions-Supplementary_Table_2_DUB_data_No_Control_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
HA7-RCC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46573
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
GSE111660_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
primary auditory cortex (core)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.901705
BRD-K32370845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0113
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_4639_KO_Tet_SRP377241	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.82437
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48278
ZNF274-21170338-K562_HELA_HEPG2_GM12878-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160293_2_v_4_celf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
yohimbic acid-4082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Urate levels in lean individuals	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01317
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
NCIH1355	DepMap CRISPR Gene Dependency	1.0	5.4069
SNU620	CCLE Cell Line Gene Expression Profiles	-1.0	-2.18796
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.98942
BRD-K32191695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46089
r2 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36005
OVTOKO	CCLE Cell Line Gene Expression Profiles	1.0	2.14488
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0665
Acute Myeloid Leukemia_LAML_TCGA-AB-2939-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PR-DUB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.04
BRD-K69791255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25378
H3K27me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.029
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15898
BRD-K67905771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34788
Granular lamina of the cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93661
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214202
cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K15694916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8247
BRD-K33102216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67281
hydrocortisone_homo sapiens_gpl201_gse21909	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsal tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71593
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45096
hsa-miR-450b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8311-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52685199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08358
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
raloxifene-376	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0555
BRD-K98418950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36173
GSE169571_3_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58058
VMRC-MELG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZE-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45947503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62526
CTSB	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PSMD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32488
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32915
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73009
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A5W6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75041866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74692
TMK1	DepMap CRISPR Gene Dependency	1.0	4.40113
BRD-K29246335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07604
biotin-2428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EW-12	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.10108
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.61666
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900668
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.9672
periventricular stratum of r2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53304
RMUG-S	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41176
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.18953
RPMI-2650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.56439
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.94608
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.093
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.528
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26D-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.81247
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83331
BRD-K71419092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22907
GSE132759_4_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Aicardi-Goutieres syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
Iris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.079
HCC78	CCLE Cell Line Gene CNV Profiles	1.0	1.47196
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.67616
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7725
urapidil-3078	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE146074_1_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
fenoprofen-2553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MDAMB361	CCLE Cell Line Gene CNV Profiles	1.0	1.54048
TRIM28	ChEA Transcription Factor Targets	1.0	null
SFTPC_KO_GSE35989_48_mouse_lung (type II cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83179
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13705
ALK_KD_GDS2724_105_human_DAOY medulloblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE131161_1_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51681402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88123
PRKCA_KO_GDS2141_300_mouse_small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K83670600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29719
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59135
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.45
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CFTR_Deficiency_GDS1843_191_mouse_Lungs - Animals examined at 3 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.6451
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
PMC11668284-BST-52-2253.nxml-Table_1-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.841154
ZBTB21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40322
Precommissural nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01027
BRD-K46549154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.99515
LOXIMVI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41176
8-MG-BA	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.32901
novobiocin-576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04688
r10 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57357
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A1JX-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16698502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83731
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.9248
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78397
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K22718400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15042
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-N-SH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dorsomedial nucleus of the hypothalamus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63016
496100396_HIP_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.34154
neuroblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.316951
BRD-K89674009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0206
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78825
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE111660_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.875395
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.36528
BRD-K29350630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02832
molecular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20441
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.70747
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07057
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34279
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.999975
BRD-K96560179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24296
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.656
GSE146074_9_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66887
KYSE510	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57009
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91525
LCLC-103H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.992526
superficial stratum of r2BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36062
BRD-K72936860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4648
mantle zone of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09236
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64602
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8A-MLX_3T3_MLX	Rummagene Transcription Factor Associations 2026	1.0	null
Pontine central gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04771
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.14266
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26235
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18261
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61912055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11752
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846978
PMC8225676-41467_2021_24150_MOESM4_ESM.xlsx-DUB_ranking_siRNA_screening-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
LN215	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66721
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
HGC27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35187
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.67449
Perturb_1089_OE_hMAPT_SRP192566	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.40951
GSE84462,GSE84762_0_v_1_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K00793226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08609
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09232
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90148
Sarcoma_SARC_TCGA-K1-A6RU-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100378_TCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.3817
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.31155
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LJ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A8BX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57365604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73618
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28384
PAX3	ChEA Transcription Factor Targets	1.0	null
MYC-19915707-AK7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
fasudil-436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
core of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82315
BFTC905	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95136
Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75869048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04212
decreased locomotor activity	MGI Mouse Phenotype Associations 2023	1.0	null
GSE157960_2_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.52
MFE296	CCLE Cell Line Gene Expression Profiles	1.0	1.46715
BRD-K34234678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62986
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23355
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.172905
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07371
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.950835
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.8755
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22874
r5 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16067
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3357
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKGI	DepMap CRISPR Gene Dependency	1.0	2.00407
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.75544
cell cycle G1/S phase transition	GO Biological Process Annotations 2023	1.0	null
r9 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.16428
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20004
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70552
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90148
endopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
Proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.848
MEL-JUSO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K36237864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38988
BRD-K89320330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5148
ethoxyquin-3764	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02233
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26491
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62838
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.36626
Ubiquitin specific protease domain	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K27109474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56576
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1985
BRD-K61795707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45392
Hypertrophy	CTD Gene-Disease Associations	1.0	1.12461
NR1I2-20693526-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0241
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.418
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
lateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13297
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.17244
BRD-K38998073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01982
endopeptidase activity	GO Molecular Function Annotations 2015	1.0	null
Anterior hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4003
HOS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cysteine-type endopeptidase activity	GO Molecular Function Annotations 2023	1.0	null
superior periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.98333
decreased litter size	MGI Mouse Phenotype Associations 2023	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6356
PMC3944256-cddis201440x1.xls-Primary_Screen_Results-Supplementary_Table_1_Synthetic-Lethal_siRNA_DUB_Screen_for_Mcl1_antagonists_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830507
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.86253
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885328
PRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66904
BRD-A84764193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92349
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0339
Perturb_9777_KO_Mettl6_ERP120512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.98914
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein modification by small protein removal	GO Biological Process Annotations 2015	1.0	null
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE147056_2_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4338
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94415
BRD-K43639523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.95011
BRD-K16372954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08961
BRD-K99377541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40111
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.266413