association dataset threshold value standardized value GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92654 H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-Q2AG-0626-SM-2S1PV GTEx Tissue Sample Gene Expression Profiles 1.0 1.47391 t-UTP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.848 HS-SULTAN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.931201 BRD-K87404495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1531 outer CP in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11989 BRD-K06049932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.015 PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null SACM1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15189 BRD-K92356505 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23287 GSE62843,GSE64370_0_v_3_furan_mouse RummaGEO Drug Perturbation Signatures 1.0 null intracellular part LOCATE Curated Protein Localization Annotations 1.0 null BRD-K79355381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0664 CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.336352 NFE2 ENCODE Transcription Factor Targets 1.0 null superficial stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03202 embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.98153 PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34681 GTEX-PX3G-1026-SM-48TZW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16852 RAD21_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4177363__F5 PFOCR Pathway Figure Associations 2023 1.0 null BRD-K38248920 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07849 HOXB4 ChEA Transcription Factor Targets 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824655 BRD-K34005205 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9136 cellular process GO Biological Process Annotations 2015 1.0 null CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K46620987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62303 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09996 primary metabolic process GO Biological Process Annotations 2015 1.0 null r5 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01476 SMAD3-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1 ENCODE Transcription Factor Targets 1.0 null AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.801936 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 2.95991 Lateral visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06763 rrna metabolic process GO Biological Process Annotations 2015 1.0 null K562 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.29571 C3orf80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27554 RHOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43375 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prelimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00811 KATOIII_STOMACH CCLE Cell Line Proteomics 1.0 3.56655 neutropenia GWASdb SNP-Phenotype Associations 1.0 0.776085 7500_RPS12_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.516743 Retrosplenial area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70638 BRD-K99331869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50307 ROCK1_knockdown_156_GSE34769 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.482 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.616944 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEx Uterus 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 12.6552 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE185519_4_v_7_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 SIN3A Pathway Commons Protein-Protein Interactions 1.0 null N-nitrosomorpholine CTD Gene-Chemical Interactions 1.0 null GTEX-V1D1-0926-SM-4JBHQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04891 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_41_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE158456_1_v_3_furin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE171572_3_v_4_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null rna binding GO Molecular Function Annotations 2015 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K96834095 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30457 A549_Pirarubicin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187649 CTCF_epithelial cell of esophagus_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IFI6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13401 striatum_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.862395 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Ribonucleoprotein complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 dorsolateral prefrontal cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02299 hsa-miR-320a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC Rummagene Transcription Factor Associations 2026 1.0 null RO82-W-1 GDSC Cell Line Gene Expression Profiles 1.0 1.8921 ZBTB18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8094 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Lenalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151425 GSE206870,GSE206872_1_v_5_ascl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null testis_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.09239 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MDA-MB-330 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.8981 Debio-1347 DeepCoverMOA Drug Mechanisms of Action -1.0 -1.24 HIST1H3B Pathway Commons Protein-Protein Interactions 1.0 null PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-NR4A2-sequence_name_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null 4950_MED27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.559618 BRD-K05977380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.73711 CRCGN008_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.15505 GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K05070188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09829 inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.878842 BRD-A07952294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13191 Posterior parietal association areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19044 A549_Carmofur_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172093 GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77726 TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.671362 Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.76397 IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.339722 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73734 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-632 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.589642 PMC11839186-CPR-58-e13756-s004.pdf-71-THAP3_THAP3 Rummagene Transcription Factor Associations 2026 1.0 null H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17910759-TableS5 GeneSigDB Published Gene Signatures 1.0 null BRD-K18724553 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67539 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.777065 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.961162 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UPK3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04561 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Divalproex Sodium_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179011 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A642-01A-12R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXA2 ENCODE Transcription Factor Targets 1.0 null GSE131680_1_v_0_macroh2a1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE227634,GSE228381_0_v_7_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE114992,GSE114993_4_v_6_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XLM4-0011-R9A-SM-4AT45 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850531 Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00446585 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7252 7512_RPS23_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.551618 GSE57871_11_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27529 HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.68985 BRD-K14262397 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03068 BRD-K20071915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01114 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K02388444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17488 PEAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54701 Spinal neurofibromatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.143 143B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01287 BRD-K06958718 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0198 BRD-K87023633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11498 GSE108326_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.42202 CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane-enclosed lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 K562_PFI-1_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016891 r9 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62977 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tonsil_8a1 HPA Tissue Sample Gene Expression Profiles 1.0 1.55329 10738_ZWINT_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.597424 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55317 GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4083 ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2393 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE188570,GSE188571_5_v_2_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null Darolutamide_A498 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.016446 Down Syndrome_Fetus_GSE10758 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.5072 GSE245270_1_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K45062933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01462 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZG-0001-SM-47JYF GTEx Tissue Sample Gene Expression Profiles 1.0 1.09792 KDM2A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41798 layer 2 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20555 RBM12B-AS1 Pathway Commons Protein-Protein Interactions 1.0 null r8 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10721 SPEN Pathway Commons Protein-Protein Interactions 1.0 null DDX51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06556 H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 7508_RPS19BP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.715636 BRD-K66963616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75732 GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.35834 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null Nucleoli CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null BRD-K54657536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03976 BRD-K03855997 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11762 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042743 gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.347092 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214823,GSE214824_5_v_7_crtc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K02920459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36618 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lopinavir_PANC-1 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0143472 A549_PFI-1_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0107908 NEPRO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19521 GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.24164 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 16207381-Table1Sb GeneSigDB Published Gene Signatures 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null Barrett Esophagus_Esophageal Tissue_GSE1420 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.26408 Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4828-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12 Rummagene Transcription Factor Associations 2026 1.0 null GSE218879_1_v_2_acetaminophen_mouse RummaGEO Drug Perturbation Signatures -1.0 null heterocyclic compound binding GO Molecular Function Annotations 2015 1.0 null GSE226584,GSE226589_3_v_0_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null NDUFA10 Pathway Commons Protein-Protein Interactions 1.0 null MFSD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14862 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.918367 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE89018_10_v_8_cry2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PCDH9 Pathway Commons Protein-Protein Interactions 1.0 null nuclear lumen GO Cellular Component Annotations 2025 1.0 null BRD-K80816131 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03948 BRD-A42536341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40932 TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2169 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3472-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rc95 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.708 HJURP Pathway Commons Protein-Protein Interactions 1.0 null GSE112762,GSE112767_2_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null EIF2AK3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K63579322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75794 GSE200673,GSE200691_2_v_0_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE216043_11_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K79152256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.827 BRD-K32723442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56496 GSE233548_3_v_0_plscr1_human RummaGEO Gene Perturbation Signatures 1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.974438 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.4966 cerebellar cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.92178 intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70835 Cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MOV10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30438 CTCF-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-0426-SM-3GACZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.03879 Anteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67101 estradiol_homo sapiens_gpl570_gse5102 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.82792 GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921345 Retrosplenial area, dorsal part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5425 Rectum adenocarcinoma_READ_TCGA-AH-6897-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chromosomal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.4 Leukemia_chronicMyelogenousK-562 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.71544 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3458-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35823 GTEX-SIU7-0001-SM-3NMAW GTEx Tissue Sample Gene Expression Profiles 1.0 1.51817 6963_PWP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.557146 MEF2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.92309 496100376_FWM_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00918 Temporal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3167 CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.06833 GSE227592_8_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null embryoday9.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.87819 A549_TMP195_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140532 AURKA_druginhibition_196_GSE57810 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.65632 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null immune system disease GWASdb SNP-Disease Associations 1.0 0.059803 HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.273201 H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE114992,GSE114993_9_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nucleus of the trapezoid body Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65978 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Nucleus ambiguus, ventral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82226 ARNT2 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.43102 GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13577 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null nuclear lumen COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 AKAP8 Pathway Commons Protein-Protein Interactions 1.0 null ELK4 ENCODE Transcription Factor Targets 1.0 null HOXB4-20404135-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null MAP3K21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12579 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.487 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22361 BRD-K66511507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22398 GSE171486_4_v_6_ddx6_human RummaGEO Gene Perturbation Signatures -1.0 null benserazide-5322 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN017_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.56705 ovary cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.415434 H2AC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28416 GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04534 GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.62434 layer 3 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10937 organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PES1 Pathway Commons Protein-Protein Interactions 1.0 null ABC-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.60488 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HL-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7538_RPS8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.801826 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1915 CCLE Cell Line Gene CNV Profiles -1.0 -1.38792 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.93982 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.867661 GTEX-WFON-0326-SM-3GIKX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.956004 Kidney Chromophobe_KICH_TCGA-KN-8429-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3HZ-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.931497 BRD-K26852477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63794 IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.937918 superficial stratum of r6Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44766 BRD-K75588273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29625 GSE113734_1_v_2_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null snoutepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.47854 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles 1.0 0.861987 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39806 A673 GDSC Cell Line Gene Expression Profiles -1.0 -1.65723 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OB-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymphnode_5c HPA Tissue Sample Gene Expression Profiles 1.0 0.956206 GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66996 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.98459 K562_Thiotepa_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173872 superficial stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37441 GSE185519_6_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6104 BRD-K36096526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43783 GSE169571_5_v_4_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null Colon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K77719922 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07998 LEF1-29337183-MESC-MOUSE-STEM ChEA Transcription Factor Targets 2022 1.0 null H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 metabolic process GO Biological Process Annotations 2015 1.0 null GSE248858_1_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles 1.0 1.05842 lymphnode_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.75365 BRD-K14081852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15889 GSE153871_5_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K12396271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01367 MG63 CCLE Cell Line Gene Expression Profiles 1.0 1.35316 Nuclear pore linkers COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.204 TCF21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3749 NFIC ENCODE Transcription Factor Targets 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60397 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10715 ULK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15725 JSC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GATA1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12867_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWCY-0526-SM-2I3ER GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881467 NCOR2 Pathway Commons Protein-Protein Interactions 1.0 null NCIH2009 CCLE Cell Line Gene CNV Profiles 1.0 1.8781 AD-77-UF99_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237433 Retrosplenial area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07413 BRD-K23085156 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48735 Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32525 dorsolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.834619 SEC16A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-N7MT-0007-SM-3GACQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959013 Nodulus (X) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38867 PMC7285791__F4 PFOCR Pathway Figure Associations 2024 1.0 null GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.830837 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.878155 CRCGN016_MCF10A.TP53.M_24H:L23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.75211 DYNLL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82644 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_11_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876954 GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Perinuclear region of cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.771 H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206870,GSE206872_0_v_2_ascl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -2.42717 GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles 1.0 1.06229 IKZF1 Pathway Commons Protein-Protein Interactions 1.0 null CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K44052748 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63176 NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.918905 Ankle joint TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.175 Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2135 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3363-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242647_2_v_0_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Perturb_18010_KO_miR17/miR20a/miR18a_SRP050491 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.9557 K562_UNC0379_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0154913 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.26858 WDR35 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15677 anthraquinone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95993 GSE143662_3_v_1_dcp2_human RummaGEO Gene Perturbation Signatures -1.0 null EHMT1 Pathway Commons Protein-Protein Interactions 1.0 null PMC6109294-13045_2018_650_MOESM1_ESM.xlsx-ST12_KEGG_JURKAT-Unnamed_11_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null A-Vietnam-1203-2004(H5N1)_2day-wtC57BL-6J_None_GSE40792 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.23402 Tofacitinib_PANC-1 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.013688 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.929245 mantle zone of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.16421 COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.916057 H1FX Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17616640-TableS1 GeneSigDB Published Gene Signatures 1.0 null CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.264 AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.274393 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K96713984 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63931 9962_ZBED2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.521454 CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00881 ZR7530 CCLE Cell Line Gene Expression Profiles -1.0 -2.20179 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.951811 KDM5A ENCODE Transcription Factor Targets 1.0 null A549_Roscovitine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172158 IM95_STOMACH CCLE Cell Line Proteomics 1.0 2.00095 GSE228413_0_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null A549_Lenalidomide_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142914 GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36661 adult retina HPM Cell Type and Tissue Protein Expression Profiles -1.0 -1.16041 TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null small-subunit processome GO Cellular Component Annotations 2025 1.0 null BRD-K27645251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86789 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null HT CCLE Cell Line Gene Expression Profiles 1.0 2.18859 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null superficial stratum of OCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16639 nocodazole-1393 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.54555 4618_LMNB2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.712802 K562_Quercetin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163887 CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03869 SW1990 CCLE Cell Line Gene CNV Profiles 1.0 1.58407 ABC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.44223 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE134375_0_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null disease GWASdb SNP-Disease Associations 1.0 0.028978 BUB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11227 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050621 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null GTEX-RUSQ-0826-SM-47JWW GTEx Tissue Sample Gene Expression Profiles 1.0 1.12449 HOXB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6629 FOSL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5182 A549_SRT3025 HCl_100nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.015343 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6550_POLR2I_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.5074 chrysophanic-acid LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09527 cell part LOCATE Curated Protein Localization Annotations 1.0 null 7508_RPS19BP1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.549566 YY1 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.02548 BRD-A35323217 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23464 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.902113 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2369 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20447 6351_PIK3C2A_ENST00000265970.7 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.522288 umbilicalcord BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.993088 NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16049 CRCGN009_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.02873 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WRNIP1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K37510443 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12619 A549_PF-3845_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0316661 hsa-miR-4803 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 BRD-K73680186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06993 7507_RPS18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.61852 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19343 H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC11103890-mmc3.xlsx-ZZZ3_interactors_ESC-2-Gene_names_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20447 BRD-K42713448 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00603 GSE143662_0_v_1_dcp2_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K27671601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52187 GSE235644_1_v_0_fasn_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K29264158 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29448 ellipticine-1765 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null WDR59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07331 Chromosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 K562 BioGPS Cell Line Gene Expression Profiles 1.0 1.13743 inner CP in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17751 K562_NVP-BSK805 2HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166614 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE201309_1_v_3_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE166315_1_v_4_docetaxel_mouse RummaGEO Drug Perturbation Signatures -1.0 null HDAC4 Pathway Commons Protein-Protein Interactions 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null Vortioxetine_SW 1271 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0166295 WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.363814 TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.05618 USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56026 RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.85885 SMC4 Pathway Commons Protein-Protein Interactions 1.0 null 7607_RUVBL1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.618177 Gingival epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.735 outer CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.862517 GSE123689_1_v_0_cbx8_human RummaGEO Gene Perturbation Signatures 1.0 null HMMR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31483 FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null 7527_RPS5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.549758 NMC-G1 GDSC Cell Line Gene Expression Profiles -1.0 -1.5164 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.34026 CTCF_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83295 GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles 1.0 1.23063 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-475 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.27124 cytosolic ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.4958 RNA polymerase I complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.471 FOSL1::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6759 GSE119978,GSE180930_2_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null MHHES1 CCLE Cell Line Gene Expression Profiles -1.0 -1.9231 H4K20me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XK95-0008-SM-4AT5G GTEx Tissue Sample Gene Expression Profiles 1.0 0.982857 PCNX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26325 PMC4909989-ncomms11840-s2.xlsx-up-regulate-The_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_regulated_genes_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.78586 GATA1::TAL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.9796 GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NF1 copy number variation syndrome WikiPathways Pathways 2024 1.0 null PHTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4275 r1 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24492 Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18565 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.895689 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.902758 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PAX5_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nucleolus COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X261-0011-R7A-SM-4E3JJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22903 BRD-K16093370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79302 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7667-01A-31R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BronchialEpithelialCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.908428 BRD-K34297711 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19838 BRD-K59831227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31906 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45344 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A6QX-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null ZBTB11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.124 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.907519 sulfathiazole-1883 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE184399_0_v_2_cnot1_human RummaGEO Gene Perturbation Signatures 1.0 null RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pineal gland Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.922537 HDAC11 Pathway Commons Protein-Protein Interactions 1.0 null Colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186810,GSE186813_7_v_5_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Hak TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.188 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LAMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15899 NRF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSMD1 Pathway Commons Protein-Protein Interactions 1.0 null EGFR_drugactivation_30_GDS4361 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.44648 6152_PDCD11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.804569 6152_PDCD11_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.00881 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null apoptosis GeneRIF Biological Term Annotations 1.0 null GCN1L1 Pathway Commons Protein-Protein Interactions 1.0 null GSE111247_14_v_10_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null 2105_DDX18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.630754 BRD-K98095706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59231 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04277 MAFK ENCODE Transcription Factor Targets 1.0 null GSE62843,GSE64370_0_v_1_furan_mouse RummaGEO Drug Perturbation Signatures 1.0 null Pwp2p-containing subcomplex of 90S preribosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 RAD21_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 2.48899 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SIX5 ENCODE Transcription Factor Targets 1.0 null brain_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.0828 SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.956985 ATP2A3 Pathway Commons Protein-Protein Interactions 1.0 null GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.8835 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.14898 PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.885252 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4852-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4718-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null SW156 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14415 BRD-K21588993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11675 CRCGN016_MCF10A.TP53.M_24H:O13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.31009 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDE10A_KO_GSE40377_581_mouse_Striatum and hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE48812_11_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null THAP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.906839 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06403 ATP6V1B1 Hub Proteins Protein-Protein Interactions 1.0 null BRD-K55965167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46931 inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13708 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114992,GSE114993_7_v_5_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 4472_KRR1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.503132 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36705 intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28931 Oxaprozin_A498 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0199917 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.57388 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE125782_3_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Chromosomal deletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.625 Retrosplenial area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8147 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BRD-K18737347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18733 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary open angle glaucoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.495 PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paragigantocellular reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4247 MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0686 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU1066 CCLE Cell Line Gene Expression Profiles -1.0 -2.81942 GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles 1.0 1.20694 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-11A-01R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043053 rna processing GO Biological Process Annotations 2015 1.0 null GTEX-X5EB-0004-SM-46MWA GTEx Tissue Sample Gene Expression Profiles 1.0 1.2162 K562_BRD4770_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015755 BRD-K07567566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26913 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M6-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.30686 Pterygium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.979 K562_RG108_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148579 GSE131798,GSE131804_1_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE168604,GSE183859_1_v_0_selumetinib_human RummaGEO Drug Perturbation Signatures 1.0 null ATAD2 Pathway Commons Protein-Protein Interactions 1.0 null Ribosome biogenesis in eukaryotes KEGG Pathways 2026 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NELFE ENCODE Transcription Factor Targets 1.0 null physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.263368 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.71624 GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23089 intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27815 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null WNK4 Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.37111 NCIH1651 CCLE Cell Line Gene Expression Profiles 1.0 3.18475 GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.47799 Prostate disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 8196_SMYD4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.71326 CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A7HU-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC-366 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.56397 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KXD1 Pathway Commons Protein-Protein Interactions 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H4K20me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11601 BRD-K50946180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39958 PMC10274973-media-3.xlsx-ST18-Unnamed_9_ST18 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.629 GSE206516,GSE206518_5_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 GTEX-QEL4-2126-SM-447AE GTEx Tissue Sample Gene Expression Profiles 1.0 0.858793 NOP2 Pathway Commons Protein-Protein Interactions 1.0 null WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04038 SIRT7 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K84241565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68525 PRPF6 Pathway Commons Protein-Protein Interactions 1.0 null 8232_SNRPF_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.516843 PPAN Pathway Commons Protein-Protein Interactions 1.0 null RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K57351233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42298 BRD-K57620855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90805 A549_Sodium Phenylbutyrate_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142294 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Other source TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.133 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32372 Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.54718 GSE103068_5_v_1_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.84597 MHHES1 CCLE Cell Line Gene CNV Profiles -1.0 -1.83644 Dense fibrillar component COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.431 A549_Ki8751_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147576 GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6818 r10 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06416 GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84966 GSE146247_0_v_1_sirt7_human RummaGEO Gene Perturbation Signatures -1.0 null GSE183994_1_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles 1.0 0.875949 GSE228413_2_v_1_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30428 Nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 BRD-K36170990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36212 A549_Ellagic acid_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166527 GRIN3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21545 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null protein complex GO Cellular Component Annotations 2015 1.0 null GSE137325_3_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RG-A7D4-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114992,GSE114993_7_v_11_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K26708780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25685 GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 1.32776 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RRP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82858 GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.21922 GTEX-SN8G-0001-SM-3NM8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.19338 SAP30 ENCODE Transcription Factor Targets 1.0 null SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.844721 centrosome GeneRIF Biological Term Annotations 1.0 null BRD-K98976117 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01432 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 VIPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28167 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K60918542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97622 HELA Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.18315 basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.89761 RFX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.601 HS578T Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.643274 UBC Pathway Commons Protein-Protein Interactions 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K35826866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37907 RNA polymerase III complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.565 metacetamol LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59777 GSE217201_1_v_0_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null OMC-1 GDSC Cell Line Gene Expression Profiles 1.0 3.02464 GSE147240_3_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE157383_3_v_2_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null Retrosplenial area, lateral agranular part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.04611 A549_2-Methoxyestradiol_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0215795 inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03911 BRD-K25702540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69436 IKZF1 ENCODE Transcription Factor Targets 1.0 null GTEX-PSDG-0008-SM-48TE5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48675 GSE184356_1_v_2_tfam_human RummaGEO Gene Perturbation Signatures 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QXCU-1926-SM-48FE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921915 PMC11884789-elife-103259-supp3.xlsx-Sheet1-Supplementary_file_3_Comparison_of_proteins_that_interact_with_R-loops_in_different_studies_to_RBPs_identified_in_NRL_interactome_NRL Rummagene Transcription Factor Associations 2026 1.0 null BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263389 Uridine_A498 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0269905 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K95672029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7652 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFE280 CCLE Cell Line Gene CNV Profiles -1.0 -1.89658 fibrinogen GAD Gene-Disease Associations 1.0 null PARP12 Pathway Commons Protein-Protein Interactions 1.0 null GSE102505_6_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11373733-ABR-13-34_Suppl1.pdf-263-ZNF682_ZNF682 Rummagene Transcription Factor Associations 2026 1.0 null imatinib_homo sapiens_gpl96_gds3047 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K02630367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29537 HMGCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65021 ZC3H3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37052 GSE119498_0_v_5_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54575 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04534 IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2234 intermediate part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37724 2124_DDX47_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.744639 ZNF14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01052 GSE153871_4_v_2_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null Glume TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.577 Spinal nucleus of the trigeminal, interpolar part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06321 CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.772771 GSE205976,GSE205978_3_v_0_cep83_human RummaGEO Gene Perturbation Signatures 1.0 null ATF3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null GTEX-P4PP-1026-SM-3NM9O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08013 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EOMES ChEA Transcription Factor Targets 1.0 null 2321_DNTTIP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.652594 TAL1_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-1426-SM-4AD66 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30525 CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE165308_1_v_0_gfi1_human RummaGEO Gene Perturbation Signatures -1.0 null Dorsal peduncular area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09582 ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.184927 GSE213588_9_v_11_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30035 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEF2A ENCODE Transcription Factor Targets 1.0 null Mesopallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.758 EKVX BioGPS Cell Line Gene Expression Profiles -1.0 -0.866678 BRD-K72029544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35714 THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.0621 A549_Droxinostat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0186272 Brain Lower Grade Glioma_LGG_TCGA-S9-A7J0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160373_5_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nucleus ambiguus, dorsal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03395 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15751 GSE212486,GSE212488_2_v_3_gata4_mouse RummaGEO Gene Perturbation Signatures 1.0 null medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.999905 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.239539 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AX-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K18211442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17154 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12075 K562_Gandotinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0123677 GATA2-22383799-G1ME-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-RTLS-2426-SM-46MUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.18073 CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r4 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72885 CRCGN017_MCF10A.WT.HP_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8899 TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73330516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.40489 GSE174498,GSE174500_3_v_4_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-320d TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 FB-49-NW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.200768 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05987 BRD-K76664579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64913 WT1-25993318-PODOCYTE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JHH-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31475 PMC7116212__F6 PFOCR Pathway Figure Associations 2024 1.0 null 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.28681 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null THRAP3 Pathway Commons Protein-Protein Interactions 1.0 null SA-32-CC58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20766 BICR22 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.92963 KOPN-8 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.45662 Asciminib_A498 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0273036 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14421 GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98911 GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32064 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-PBX3-Members_of_the_PBX3_regulon_as_identified_by_SCENIC_PBX3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE185519_1_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null LOXIMVI GDSC Cell Line Gene Expression Profiles 1.0 1.41803 BRD-K09560946 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51023 POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33186 GSE153836_14_v_1_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SK-N-DZ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.920026 SNU668 CCLE Cell Line Gene Expression Profiles -1.0 -1.76556 CRCGN016_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.75889 BRD-K86073842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25593 H3K4me1_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null UBE2E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48249 GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57967 Sarcoma_SARC_TCGA-JV-A5VE-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Nuclear lumen COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 GSE119498_6_v_4_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207925 GSE195663_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null nucleus LOCATE Curated Protein Localization Annotations 1.0 null GSE153354_0_v_1_tcf19_human RummaGEO Gene Perturbation Signatures 1.0 null PMC8755441-mmc3.xlsx-IRF7-Up-stat1-hela_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null r10 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67721 NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BAG2 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29095 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31204 F36P CCLE Cell Line Gene CNV Profiles -1.0 -1.48737 CRCGN017_MCF10A.WT.HP_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.4769 Accessory olfactory bulb, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5467 K562_Andarine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148459 HAT (Half-A-TPR) repeat InterPro Predicted Protein Domain Annotations 1.0 null GSE226584,GSE226589_2_v_0_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.43155 MET_knockout_264_GSE8747 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.63915 TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE197630_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null K562_PD173074_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171031 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36773 BRD-K01787291 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0241 A4FUK CCLE Cell Line Gene Expression Profiles 1.0 1.49153 U251 BioGPS Cell Line Gene Expression Profiles -1.0 -0.9251 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFAP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.412 BRD-K43203897 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38154 CTCF_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ST6GAL1_Deficiency_GDS3151_608_mouse_Mammary tumors GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A549_UNC0631_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0134729 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null placenta BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.31077 DROSHA Pathway Commons Protein-Protein Interactions 1.0 null CTCF-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles 1.0 2.34889 CIRH1A Pathway Commons Protein-Protein Interactions 1.0 null CAS1 CCLE Cell Line Gene CNV Profiles 1.0 1.49652 GSE211286_1_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null TAL1 ChEA Transcription Factor Targets 1.0 null DKC1 Pathway Commons Protein-Protein Interactions 1.0 null JcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00134 OE33 CCLE Cell Line Gene CNV Profiles 1.0 1.49781 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17043 SKNAS CCLE Cell Line Gene CNV Profiles -1.0 -1.51999 STAT3 ENCODE Transcription Factor Targets 1.0 null Granular component COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.566 A549_Mercaptopurine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176785 r6 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11017 BRD-K93159873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17938 Epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YBX2 Pathway Commons Protein-Protein Interactions 1.0 null uterine cervix TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null A549_TMP195_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0127901 GSE116810_2_v_0_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Thiotepa_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158112 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Simotinib_A498 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0183902 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63531 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE118548_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.871015 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE179974_3_v_0_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K79me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FEZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05331 GSE180800,GSE180801_0_v_5_tex10_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15653 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.75313 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25825 epithelial cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050715 BRD-K37062347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12435 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 0.871923 CTCF_WI38_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles 1.0 1.40224 YBX3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles 1.0 2.375 496100347_PCx_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13737 BRD-K98953112 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10485 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.5891 UBR5 Pathway Commons Protein-Protein Interactions 1.0 null lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27157 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null Groin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.724 BRD-A28153253 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3861 LSM1 Pathway Commons Protein-Protein Interactions 1.0 null hydroquinone_homo sapiens_gpl570_gse31641 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.89815 GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles 1.0 1.79717 GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935942 Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XPVG-0726-SM-4B658 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.978034 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null Bowen-Conradi syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.667 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.73069 M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.976504 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-70-BD07_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.44168 MYC-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null IRF4 ENCODE Transcription Factor Targets 1.0 null Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46983 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.859541 Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206729_5_v_1_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.25865 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10326 H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE219195_1_v_3_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null Primary somatosensory area, lower limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10055 Perturb_1067_KD_PHF19_SRP188592 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.40372 K562_Curcumin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.018379 CAL-120 COSMIC Cell Line Gene Mutation Profiles 1.0 null prostate gland epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_6878_KD_LINC00857_SRP371132 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.31951 GTEX-T8EM-0006-SM-3DB71 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844705 BRD-K76350099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49818 GTEX-WH7G-1626-SM-4LVMY GTEx Tissue Sample Gene Expression Profiles 1.0 1.06339 CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03455 BRD-K69960043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2234 ZMYM2 Pathway Commons Protein-Protein Interactions 1.0 null death-inducing signaling complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.807 GTEX-RWS6-0001-SM-3NMAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.59 PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular non-membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null layer 3 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09758 NCI-H841 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lek TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.277 solitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.922304 SMC3 Pathway Commons Protein-Protein Interactions 1.0 null eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hca66 GeneRIF Biological Term Annotations 1.0 null posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.888298 nucleus of the central acoustic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18101 PMC9883165-41375_2022_1744_MOESM4_ESM.xlsx-CEBP_gene_module-CEBP_gene_module_with_gene_expression_data_and_ChIP_target_status_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null GSE158834_1_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF574 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06794 CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K18074484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74666 PNN Pathway Commons Protein-Protein Interactions 1.0 null maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO Biological Process Annotations 2025 1.0 null GTEX-XXEK-0126-SM-4BRVU GTEx Tissue Sample Gene Expression Profiles 1.0 1.72207 CTCF_WI38_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K27458941 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83825 GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50495 H3K4me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null K562_Ruxolitinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141704 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE138863_2_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null cisplatin_mus musculus_gpl339_gds3099 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTF2H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46107 JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.953165 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF ChEA Transcription Factor Targets 1.0 null hsa-miR-4775 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67342 GSE145311_1_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Ruxolitinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160372 MXI1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RNOR-0011-R4A-SM-3GAD3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848914 KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.969053 Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.98718 GSE216413_1_v_0_gata3_human RummaGEO Gene Perturbation Signatures -1.0 null PEBP1_KO_GDS4334_617_mouse_Pancreatic beta cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 10971_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.644951 PMC10244377-41467_2023_38797_MOESM7_ESM.xlsx-4d_BioGRID_RBP-BIOGRID_CDC5L_CDC5L Rummagene Transcription Factor Associations 2026 1.0 null ISTMES2 CCLE Cell Line Gene CNV Profiles 1.0 1.39587 BRD-K83272071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11611 Spinal nucleus of the trigeminal, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32889 FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00958 Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K36298208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65136 Perturb_9383_KD_Cdk19_SRP197255 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 GTEX-QLQ7-0526-SM-2I5G3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00475 K562_ZM 447439_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148866 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -3.06089 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null FOXD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22165 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979486 GSE153871_4_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null A549_Carmofur_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155515 ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.105503 E2F4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE235390_4_v_0_lurbinectedin_human RummaGEO Drug Perturbation Signatures -1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.459 nucleolus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-NL3G-0008-SM-4E3JX GTEx Tissue Sample Gene Expression Profiles 1.0 1.03372 CEP104 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29301 epithelioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null GSE186810,GSE186813_7_v_0_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null GSE79291_1_v_2_streptozotocin_mouse RummaGEO Drug Perturbation Signatures 1.0 null A549_Azacitidine_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0133822 A549_Alisertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150827 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15818 organelle LOCATE Curated Protein Localization Annotations 1.0 null A549_Hesperadin_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0127523 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of r1Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05538 polysome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.24424 GTEX-XYKS-1726-SM-4E3IO GTEx Tissue Sample Gene Expression Profiles 1.0 1.01364 pancreas HPA Tissue Gene Expression Profiles -1.0 -1.58172 posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35604 GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2544 SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SU-DHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.15127 NCI-H64 COSMIC Cell Line Gene Mutation Profiles 1.0 null UACC-893 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50588 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE210101,GSE210114_2_v_9_urod_human RummaGEO Gene Perturbation Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neurofibromatosis 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.379 SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Tozasertib_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0119967 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.860159 Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6363-11A-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-0008-SM-4KL24 GTEx Tissue Sample Gene Expression Profiles 1.0 0.912 Abemaciclib_SHP-77 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.011709 NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fibrosis CTD Gene-Disease Associations 1.0 1.06152 H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mycophenolic acid DeepCoverMOA Drug Mechanisms of Action -1.0 -2.25 GSE211128_4_v_6_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null TAL1_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K90741031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58236 GSE242290_1_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.47589 periventricular stratum of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93639 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null GSE153137,GSE153140_2_v_1_mettl5_mouse RummaGEO Gene Perturbation Signatures -1.0 null PLBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09417 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE151090_0_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60915 CRCGN016_MCF10A.TP53.M_24H:D18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4718 A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.35126 GSE75976_3_v_6_abl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ASXL1-24218140-BMDM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null A673 CCLE Cell Line Gene CNV Profiles -1.0 -1.70721 BRD-K90675978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46886 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.329727 GSE188570,GSE188571_3_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K42367391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10151 Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.6981 Pancreatic adenocarcinoma_PAAD_TCGA-2L-AAQA-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K70936779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8053 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15291 embryoday8.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.33344 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A954-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null A549_SRT2104_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156972 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.42447 YAP1-20516196-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null KMS-12-BM COSMIC Cell Line Gene Mutation Profiles 1.0 null FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146982_7_v_5_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K98595604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60153 GSE136894_1_v_0_psen1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cytosolic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.095499 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null salivary gland HPA Tissue Gene Expression Profiles -1.0 -0.892794 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.243918 organelle part GO Cellular Component Annotations 2015 1.0 null GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05246 ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.5137 K562_MLN8054_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.013444 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.05573 CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPN-0011-R2A-SM-2I5FB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.952907 MDAMB361 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.745478 CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Barasertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147966 K562_FLLL32_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152925 GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03308 BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.332279 Fog2_KO_GDS3659_152_mouse_adult heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BL2791 (PTEN) NURSA Protein Complexes 1.0 null GSE211226_1_v_2_sirpa_mouse RummaGEO Gene Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17128 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.878699 MCF7 CCLE Cell Line Gene CNV Profiles -1.0 -1.60138 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.54685 BRD-K73872184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47785 PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.035132 posteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93845 r4 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04268 GPBP1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32254 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13284 ATF1 ENCODE Transcription Factor Targets 1.0 null superficial stratum of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20533 CRCGN015_MCF10A.WT.HP_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.10255 ZGLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60517 TAL1_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30264389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08966 primary motor-sensory cortex (samples)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28073 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.575 GATA1_G1E-ER4_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10731 GSE201309_4_v_8_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal neutrophil cell number GWASdb SNP-Phenotype Associations 1.0 0.776085 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A818-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5B ChEA Transcription Factor Targets 1.0 null BRD-K78812892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46717 MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.89784 Ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.669 A549_CUDC-101_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0198828 GTEX-W5X1-0426-SM-3GILB GTEx Tissue Sample Gene Expression Profiles 1.0 1.09178 TAF1 ENCODE Transcription Factor Targets 1.0 null rRNA modification in the nucleus and cytosol Reactome Pathways 2024 1.0 null CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24782 COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.60449 KMM1 CCLE Cell Line Gene Expression Profiles 1.0 1.70026 A549_Fulvestrant_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163902 Specific developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.267 ZMYND8 Pathway Commons Protein-Protein Interactions 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_13_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K56987307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34064 stability GeneRIF Biological Term Annotations 1.0 null FLI1 ChEA Transcription Factor Targets 1.0 null BRD-K27111500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70967 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.998074 GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862935 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38019 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null preweaning lethality, complete penetrance MGI Mouse Phenotype Associations 2023 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMRT1-23473982-TESTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE218060_7_v_6_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K24259871 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02061 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.83819 NEC8 GDSC Cell Line Gene Expression Profiles 1.0 1.4564 GTEX-QLQW-0126-SM-447BK GTEx Tissue Sample Gene Expression Profiles 1.0 1.07412 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11625 BRD-K81939454 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1608 BCLAF1 ENCODE Transcription Factor Targets 1.0 null RAD21_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962165 NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.96467 organelle LOCATE Predicted Protein Localization Annotations 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2508 DAOY COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K90360779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08169 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE249404_0_v_1_oxytocin_human RummaGEO Drug Perturbation Signatures 1.0 null 496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -4.84126 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mcf7 HPA Cell Line Gene Expression Profiles -1.0 -1.12593 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94858557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30298 membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 GSE184884_2_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0487 496100358_HIP_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.2828 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Frontal pole, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.46278 eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nucleolus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.059 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.22109 TE-11 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.80183 Intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SAOS2 BioGPS Cell Line Gene Expression Profiles -1.0 -2.3879 Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45777 CTCF_GM12868_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H0-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null AOB, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7533 GTEX-POYW-1226-SM-2XCEP GTEx Tissue Sample Gene Expression Profiles 1.0 1.4031 H3K9ac_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null Caov-3 GDSC Cell Line Gene Expression Profiles -1.0 -2.20452 GSE235390_4_v_2_lurbinectedin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE240030,GSE252532_0_v_2_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K68247783 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9224 BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.295747 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07317 MAX_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A40E-01A-12R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7497_RPS10-NUDT3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.561002 CRCGN016_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.66881 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18975 BEN CCLE Cell Line Gene Expression Profiles -1.0 -1.53161 rostral ventrolateral reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.42087 TAF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5054126-mmc4.xls-SCX_GPM-Protein_identification_by_GPM_databse_search_from_SCX_fractionated_samples_SCX Rummagene Transcription Factor Associations 2026 1.0 null BRD-K40011635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3816 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06281 GSE234289_4_v_1_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.03795 FIH_Deficiency_GDS3769_511_mouse_Immortalized embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.922027 Lung squamous cell carcinoma_LUSC_TCGA-66-2755-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Crizotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140999 GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30398 EFM19 CCLE Cell Line Gene CNV Profiles 1.0 2.00123 LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5933 Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4878-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RM2N-0326-SM-48FD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898495 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2B ENCODE Transcription Factor Targets 1.0 null OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56487 BRD-K30628727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19935 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE134375_0_v_2_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null heart GTEx Tissue Gene Expression Profiles -1.0 -1.41779 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.39974 outer portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20153 scoulerine-1742 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COV413B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20447 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02359 BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.519298 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102505_4_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures 1.0 null nucleus subceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.35827 cellular aromatic compound metabolic process GO Biological Process Annotations 2015 1.0 null ZBTB44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27261 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MYC_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.84591 SW837_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 4.71675 GTEX-NL3H-0011-R2a-SM-2I3GG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954561 GTEX-SUCS-0008-SM-4DM53 GTEx Tissue Sample Gene Expression Profiles 1.0 0.887906 CRCGN014_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.51045 CTCF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08184 GTEX-WHSE-0011-R4A-SM-3P5ZN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849733 H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A61B-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNF4A ChEA Transcription Factor Targets 1.0 null DMRT1-23473982-TESTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K32402344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11487 CRCGN014_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3361 H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.852249 16207381-Table1Sa GeneSigDB Published Gene Signatures 1.0 null intermediate stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49346 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null BRD-K08534346 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35 snoRNA binding GO Molecular Function Annotations 2023 1.0 null GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0627 TCF12 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fibrinogen dbGAP Gene-Trait Associations 1.0 0.233562 H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SF3A1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K59821372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62255 SMO Pathway Commons Protein-Protein Interactions 1.0 null Heart - Atrial Appendage GTEx Tissue Gene Expression Profiles 2023 1.0 1.29276 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06845853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0011 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.870093 CRCGN017_MCF10A.TP53.M_24H:J01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.30305 HIF1AN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27133 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null UBAC1 Pathway Commons Protein-Protein Interactions 1.0 null WNT16 Pathway Commons Protein-Protein Interactions 1.0 null owing GeneRIF Biological Term Annotations 1.0 null H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XYKS-2526-SM-4BOPX GTEx Tissue Sample Gene Expression Profiles 1.0 1.17949 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.90804 GABP-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K74811560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17526 GSE212486,GSE212488_0_v_1_gata4_mouse RummaGEO Gene Perturbation Signatures -1.0 null peripheral nerve sheath neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.883521 less GeneRIF Biological Term Annotations 1.0 null PcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08475 GTEX-XQ8I-0126-SM-4BOPL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01875 NEUROG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5361 BRD-K51927648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45187 BRD-K45222498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54826 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26091 Gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F4_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K53889798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33744 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.066381 r9 part of spinal trigeminal nucleus, interpolar part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0407 GSE206516,GSE206518_2_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K39761541 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42061 CHSA0108 COSMIC Cell Line Gene Mutation Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2819-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K05462252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03987 mantle zone of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32826 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SNRNP25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20484 CA11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21188 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE147613_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4508 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 HOXA7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.3233 NKX6-1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5577 GTEX-QEG4-0008-SM-48TYZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.09488 BRD-K75529374 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47792 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.23242 layer 2 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6184 GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles 1.0 1.00834 H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null VMRC-RCW Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.47781 GATA1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null JAK1_druginhibition_166_GSE38335 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -0.965977 GSE57871_6_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null BCL6B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.6277 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNF227 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.198 BRD-K77480803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47574 H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K92635027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22284 TTF2 Pathway Commons Protein-Protein Interactions 1.0 null SAE1 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.858744 GSE221742,GSE221743_1_v_0_sipa1_human RummaGEO Gene Perturbation Signatures 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.10868 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 1.59519 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CX-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.144 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03291 CRCGN015_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.10219 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IL-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EM2 CCLE Cell Line Gene CNV Profiles 1.0 1.80982 GSE153871_5_v_2_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.225444 GTEX-XXEK-0626-SM-4BRWE GTEx Tissue Sample Gene Expression Profiles 1.0 0.834213 A549_Fluorouracil_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176074 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149903_0_v_1_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-395-ZNF418_ZNF418 Rummagene Transcription Factor Associations 2026 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.27689 BRD-K98432726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01125 K562_Dasatinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0128508 BRD-K34169251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24594 A549_Azacitidine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158039 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Enzastaurin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014969 GSE136622_0_v_3_srpk3_mouse RummaGEO Gene Perturbation Signatures 1.0 null BE-27-RQ61_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2468 MHH-NB-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.924695 2925_FAM50A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.583413 appendix HPA Tissue Gene Expression Profiles 1.0 0.88122 GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.908974 GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.20319 HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null AR-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 20174566-TableS1 GeneSigDB Published Gene Signatures 1.0 null Adipose tissue TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.316 ELOVL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11968 GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17257 GTEX-TSE9-2626-SM-4DXV2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.90769 NKRF Pathway Commons Protein-Protein Interactions 1.0 null organelle part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049055 SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.94751 Visual areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05753 GATA1-22383799-G1ME-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE159893_2_v_1_genistein_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K11399565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14003 NMD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1207 MAML1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00994 primary motor cortex (area M1, area 4)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.836057 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BATF ENCODE Transcription Factor Targets 1.0 null GTEX-WHSE-0011-R2A-SM-3P5ZL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891476 BRD-K45734531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40948 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40252 19061838-TableS7 GeneSigDB Published Gene Signatures 1.0 null thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.051321 FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21573 NKX6-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2101 r2 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25205 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040495 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.569656 TAL1-20566737-PRIMARY-FETAL-LIVER-ERYTHROID-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K77797840 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03588 AU565 CCLE Cell Line Gene CNV Profiles -1.0 -1.32967 DMS454 CCLE Cell Line Gene Expression Profiles -1.0 -1.52545 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-2726-SM-4JBH9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.921572 GTEX-POMQ-0326-SM-2I5FO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87967 K562_2-Methoxyestradiol_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153203 colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null inner CP in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08276 CHD1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null leukocyte disease GWASdb SNP-Disease Associations 1.0 0.349267 MCM2 Hub Proteins Protein-Protein Interactions 1.0 null BRD-K33128056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30165 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.268129 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles 1.0 2.03358 pancreas_6b HPA Tissue Sample Gene Expression Profiles -1.0 -2.05235 E2F1-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57473 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01594 GATA4-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4814-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K69922285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15695 H3K79me2_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44092 MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5106 GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 2.05329 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO Biological Process Annotations 2023 1.0 null GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1 Rummagene Transcription Factor Associations 2026 1.0 null primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.826149 GTEX-WHSE-0011-R1A-SM-3P5ZK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909701 BCLAF1 Pathway Commons Protein-Protein Interactions 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BMS1 Hub Proteins Protein-Protein Interactions 1.0 null GSE166783_8_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP2 ENCODE Transcription Factor Targets 1.0 null CRCGN015_MCF10A_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7524 RELA ENCODE Transcription Factor Targets 1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05772 H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XUJ4-0626-SM-4BOOO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05685 GSE151090_5_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null JHH4 CCLE Cell Line Gene CNV Profiles 1.0 1.38516 H3K27ac_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FLI1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2313_DNM2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.593579 BJAB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22824 GSE232472_1_v_2_apoe_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.4919 posteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58163 REST ENCODE Transcription Factor Targets 1.0 null GSE138672_0_v_1_rabgef1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF Rummagene Transcription Factor Associations 2026 1.0 null CRCGN009_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.83494 GSE231745_1_v_0_venetoclax_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K18768055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.05723 Small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.746 PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-GSEA_TET1-CCRF-CEM_SCR_vs_TET1_TET1 Rummagene Transcription Factor Associations 2026 1.0 null breast carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.290103 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244437 GTF2B ENCODE Transcription Factor Targets 1.0 null TP63 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4564 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046254 NABP1 Hub Proteins Protein-Protein Interactions 1.0 null Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54935 GSE186810,GSE186813_7_v_0_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927998 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.284814 CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles 1.0 2.70258 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A8BP-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-0326-SM-3GAF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12599 GSE239844_8_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null Retrosplenial area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23848 GSE119978,GSE180930_6_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70H-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K41829399 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03839 MHH-ES-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.57973 BRD-K13229082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78066 Posterior parietal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34582 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35948 Box C/D RNP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.785 vitamin c_homo sapiens_gpl570_gds3635 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_HEPG2_48H:F04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.52723 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Spz1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.3333 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K15202679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1733 GTEX-WQUQ-1426-SM-3MJFD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859209 CRCGN011_HEPG2_24H:I15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2229 NCI-H1651 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF4A-19761587-HUMAN INTESTINAL CELL LINE CACO-2-human ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-0726-SM-3GIJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21369 FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.36247 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE233548_2_v_0_plscr1_human RummaGEO Gene Perturbation Signatures 1.0 null dorsal juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4065 PPARGC1A Pathway Commons Protein-Protein Interactions 1.0 null BRD-K24292260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14936 CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.59985 intracellular organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.663381 UBTF ENCODE Transcription Factor Targets 1.0 null JAK2_druginhibition_168_GSE38335 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -0.965977 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1 JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K59263278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85723 CTCF_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF396 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11711 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K75007044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15566 H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null metaphase_anaphase_telophase_15min_noscapine_release vs ctrl_HeLa (Human) [19691289] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs -1.0 null lateral superior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47801 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1184 CCLE Cell Line Gene CNV Profiles 1.0 1.74345 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RING1B-27294783-CHIP-SEQ-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.26558 OVKATE CCLE Cell Line Gene Expression Profiles -1.0 -3.11351 r8 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5254 GSE118077_7_v_2_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.981736 TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36035 GTEX-XMK1-0126-SM-4B65F GTEx Tissue Sample Gene Expression Profiles 1.0 1.15488 BRD-K36798110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26568 T98G COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K18ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.882972 KALS-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.70516 CRCGN017_MCF10A.WT.HP_24H:G12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3591 H3K27me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, lateral agranular part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29246 A549_Cediranib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160087 HS 675.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24918 BRD-K29597572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.156 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -0.859682 maturation of SSU-rRNA GO Biological Process Annotations 2025 1.0 null CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.95344 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.01301 Alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.591903 BRD-K25761766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59355 GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles 1.0 1.13532 GLT8D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18576 TAL1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05122 HGC-27 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K80965028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1469 gamma-tubulin large complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.226 GSE216043_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null SB-228357 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51014 GSE206516,GSE206518_3_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K62068620 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65739 GSE103122_0_v_1_puromycin_human RummaGEO Drug Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.69216 GSE186810,GSE186813_7_v_5_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE130246_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null nucleolus GO Cellular Component Annotations 2015 1.0 null AB-33-EM56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.473813 GSE245134_0_v_1_atg5_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.239 NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.56188 Scoliosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.233 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01874 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29398 EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5384 GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10584 tonsil HPA Tissue Gene Expression Profiles 1.0 1.34087 lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17855 Lung squamous cell carcinoma_LUSC_TCGA-77-8156-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7501_RPS13_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.4166 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61G-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PARK7_KD_GDS3750_2_human_SH-SY5Y GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09737 Pancreatic adenocarcinoma_PAAD_TCGA-F2-6879-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.08386 HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14903 Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46938 FOXA1 JASPAR Predicted Transcription Factor Targets 1.0 null KMT2B Pathway Commons Protein-Protein Interactions 1.0 null RNA binding GO Molecular Function Annotations 2023 1.0 null POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257261 BRD-K90003650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1335 nucleolus GO Cellular Component Annotations 2023 1.0 null 5735_NOL6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.622398 K562_Meprednisone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0143815 BATF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XXEK-1226-SM-4BRUY GTEx Tissue Sample Gene Expression Profiles 1.0 1.60647 BRD-K56890200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00345 skbr3 HPA Cell Line Gene Expression Profiles -1.0 -1.62846 GSE210885_0_v_7_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null SON Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QDT8-0326-SM-32PL1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.894345 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-O5YT-0008-SM-4E3IQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.08426 BRD-K92009052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10378 Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32283 hsa-miR-4282 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q1-06A-21R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Anacardic Acid_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155747 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03455 PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S7-Table_S7_Top_500_differentially_modified_gene_bodies_between_MM_and_its_precursors_in_AA_patients_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.033566 primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04437 nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18272 MDA-MB-361 GDSC Cell Line Gene Expression Profiles -1.0 -1.82501 CLPB Pathway Commons Protein-Protein Interactions 1.0 null GEMIN4 Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KC-A7FD-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_CUDC-101_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014666 r9 part of the lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64411 maturation of SSU-rRNA GO Biological Process Annotations 2023 1.0 null posterior (caudal) superior temporal cortex (area 22c)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25948 GSE138741,GSE138743_0_v_1_lin28b_human RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12471 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-0004-SM-4AT5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.988081 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of cellular immune system GWASdb SNP-Phenotype Associations 1.0 0.192161 8228_SNRPD1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.661553 CRCGN013_HEPG2_24H:F15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0371 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COR-L279 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -5.09191 BRD-K62957665 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10319 BRD-K11696817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51726 GTEX-QEL4-0526-SM-3GIJ4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.953757 PBK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00578523 GSE152432_6_v_0_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-W5WG-2326-SM-3GIJH GTEx Tissue Sample Gene Expression Profiles 1.0 0.90902 USF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4891 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE234637_1_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null HDAC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44979 RARA-24833708-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Prostate gland epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SIN3A_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF324 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58859 HCC1395_BREAST CCLE Cell Line Proteomics 1.0 3.8181 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06347 GATA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8094 CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null open-angle glaucoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.431 USF2 ENCODE Transcription Factor Targets 1.0 null H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE81193_0_v_4_irf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02723 GSE217694_3_v_2_pold1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE206516,GSE206518_3_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null Organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 CRCGN013_HEPG2_24H:I14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.23816 GTEX-SE5C-0426-SM-4BRUI GTEx Tissue Sample Gene Expression Profiles 1.0 0.826694 hippocampus (hippocampal formation)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26329 BRD-K84143716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49229 MAMDC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23341 SRF ENCODE Transcription Factor Targets 1.0 null NIX_Deficiency_GDS2630_655_mouse_Spleen GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null RARB-27405468-CHIP-SEQ-BRAIN-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mantle zone of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03838 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 H3K9ac_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877764 Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.17162 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Glaucoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.174 GATA1_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r5 part of the oral Sp5 subnucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01568 CABLES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41574 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43544 CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null GSE119978,GSE180930_3_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15653 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6537 superficial stratum of r3BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00127 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Hippocampus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null MV-4-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.55515 Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68734 GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null NFYA ENCODE Transcription Factor Targets 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.11613 NFYB ENCODE Transcription Factor Targets 1.0 null TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Enamel epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.346 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23197669 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06472 AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4237 MSH6 Pathway Commons Protein-Protein Interactions 1.0 null head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Adenocarcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KURAMOCHI GDSC Cell Line Gene Expression Profiles -1.0 -2.12398 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 membrane-enclosed lumen COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMIM20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13675 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25484 liver_a HPA Tissue Sample Gene Expression Profiles -1.0 -0.90572 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K64767126 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03587 GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles 1.0 1.44337 TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.937 Leukemia_promyelocytic-HL-60 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.39396 PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF Rummagene Transcription Factor Associations 2026 1.0 null SYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25114 Nuclear exosome targeting complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.637 JHOM2B CCLE Cell Line Gene CNV Profiles -1.0 -1.40242 HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.47644 A549_Meprednisone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145622 BRD-K23316938 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50054 CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.706 Primary somatosensory area, trunk, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34131 SCC4 CCLE Cell Line Gene CNV Profiles -1.0 -2.81953 GTEX-Q2AH-0226-SM-48U1I GTEx Tissue Sample Gene Expression Profiles 1.0 1.23345 Lung adenocarcinoma_LUAD_TCGA-91-6836-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OC-10-FB51_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240148 A549_Pelitinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0126809 GSE93309_1_v_0_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE123825_2_v_3_glud1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ABC1 CCLE Cell Line Gene CNV Profiles -1.0 -2.05622 CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null TRIM21 Hub Proteins Protein-Protein Interactions 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.12309 GTEX-WHSE-3026-SM-3P5ZH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00183 GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.0217 GSE211286_4_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K64132098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04505 BRD-K71274071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56899 MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.61918 H3K9ac_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K67905771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17903 Chromosome 15q26-qter deletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.766 SF295 CCLE Cell Line Gene CNV Profiles 1.0 1.47252 membrane-enclosed lumen COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Tetratricopeptide-like helical domain InterPro Predicted Protein Domain Annotations 1.0 null ZNF665 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58943 GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles 1.0 1.60197 H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4891 BRD-K79494396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0826 GSE231641_0_v_1_robo1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Sarcoma_SARC_TCGA-SG-A849-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null B-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.267 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE118766_2_v_0_ifng_mouse RummaGEO Gene Perturbation Signatures -1.0 null CPT1A Pathway Commons Protein-Protein Interactions 1.0 null 7498_RPS10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.581217 K562_Maraviroc_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151833 GTEX-XUJ4-0526-SM-4BOON GTEx Tissue Sample Gene Expression Profiles -1.0 -0.956055 ribosomal small subunit biogenesis GO Biological Process Annotations 2023 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Poisoning CTD Gene-Disease Associations 1.0 1.42266 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.917165 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-346 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 USF1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE171177,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null PDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6001 CTCF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:E21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6567 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139987_1_v_2_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.847773 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN012_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6161 Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4395-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 9687_UTP6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.835659 SMAD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74283 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-CI-6623-01B-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.40445 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U-87-MG GDSC Cell Line Gene Expression Profiles 1.0 1.7589 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K08141534 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38841 H3K4me3_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836183 BRD-K94962942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28926 H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67123 OE33 COSMIC Cell Line Gene Mutation Profiles 1.0 null A549_Iniparib_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0126591 GSE242096,GSE242098_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64074 GSE254517_1_v_0_irf7_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21566 LMX1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8892 A549_Busulfan_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0206044 GATA1_G1E-ER4_mm9_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125014_6_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null nuclear part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 ribonucleoprotein complex biogenesis GO Biological Process Annotations 2023 1.0 null CTCF_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Minor Salivary Gland GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.26964 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.764648 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.88142 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hematopoietic system disease GWASdb SNP-Disease Associations 1.0 0.11996 GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.907917 Lung squamous cell carcinoma_LUSC_TCGA-46-3765-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29416 DNAH9 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GATA1_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HHIP Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_0_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null BF-97-LS55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214468 cisplatin_mus musculus_gpl339_gse6206 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A549_Sirtinol_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163237 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7383-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A23980907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73724 BE-38-UW72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265171 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null non-membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 CRCGN011_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4509 GSE120413,GSE120447_4_v_2_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null bone BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.915933 GTF3C2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Temporal association areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34452 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5019 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.86464 GSE128099,GSE128159_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JM-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null D283MED CCLE Cell Line Gene CNV Profiles 1.0 1.34353 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K45043387 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52409 7521_RPS29_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.536902 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64074 H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ChIP_TIP60_20946988 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TWF2 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null PML ENCODE Transcription Factor Targets 1.0 null BRD-K88087295 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52412 Alveolar bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.899 4472_KRR1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.615463 GSE149139_1_v_0_carm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199204,GSE211619_4_v_7_glutamine_human RummaGEO Drug Perturbation Signatures -1.0 null A-375 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08002 AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.230131 K562_WP1066_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0198724 GTEX-XGQ4-0126-SM-4AT4H GTEx Tissue Sample Gene Expression Profiles 1.0 1.46112 DLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.0439 496100499_PCx_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.92782 r7 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.40599 NT5C3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26863 HUVEC Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.3177 DMRT1 ChEA Transcription Factor Targets 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100597_HIP_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05585 inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.929597 JM1 CCLE Cell Line Gene Expression Profiles 1.0 1.47708 NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r6Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1761 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null neurofibromatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.58433 rrna processing GO Biological Process Annotations 2015 1.0 null CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K34851865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08133 peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59884 496100580_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.32319 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE215086_8_v_6_batf_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.952765 Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC Rummagene Transcription Factor Associations 2026 1.0 null CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Indacaterol (maleate)_PANC-1 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0219582 GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles 1.0 1.29973 GSE216043_11_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K00418890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69916 GB-73-QS80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.22628 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Congenital syphilis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.489 7536_RPS6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.833825 NCI-H748 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles 1.0 1.49712 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.89537 H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles 1.0 1.38323 ZBTB33_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Sodium Phenylbutyrate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148202 NOP56 Pathway Commons Protein-Protein Interactions 1.0 null nuclear lumen GO Cellular Component Annotations 2023 1.0 null wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.58188 NKX6-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.2924 GSE231799_2_v_5_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.65185 KDM1A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38497 r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68323 POU2F3 Pathway Commons Protein-Protein Interactions 1.0 null adenocarcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.09201 nucleolus LOCATE Curated Protein Localization Annotations 1.0 null Peripheral nervous system neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.46 VCAP CCLE Cell Line Gene CNV Profiles 1.0 2.08112 GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 2.16019 GSE140092_0_v_1_socs3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Dehydration_Hypothalamus_GSE3125 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.17397 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Frontal pole, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09348 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FI-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.66815 LPAR4 Pathway Commons Protein-Protein Interactions 1.0 null TRIB3 Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null organelle lumen COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 A549_Epothilone A_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0103858 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.907608 BRD-K96459367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27356 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Ectorhinal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0456 wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.013882 GSE136894_2_v_3_psen1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NIX_Deficiency_GDS2630_160_mouse_spleen GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.493 CRCGN016_MCF10A.TP53.M_24H:C18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.035 PMC12513837-41588_2025_2336_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_List_of_AR-only_and_p300_AR-shared_enhancer_regulated_genes_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Plexiform neurofibroma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.616 DYNLRB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07826 RAD21_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214823,GSE214824_5_v_1_crtc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE239844_11_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T5JC-0011-R9A-SM-32PLV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01347 GSE239844_4_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null 5548_NDUFAF5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.612763 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7247-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28851 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T7-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K14ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE182680,GSE182683_0_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.414276 PMC12423794-ao5c05859_si_001.pdf-45-ZNF207_ZNF207 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3352-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54143 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.909943 POU4F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.058 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2A ENCODE Transcription Factor Targets 1.0 null GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K25337138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2455 RFX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0754 NCI-H211 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE138001_5_v_4_rorb_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 GSE64642_0_v_1_sirt6_human RummaGEO Gene Perturbation Signatures -1.0 null 5731_NOC4L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.728654 organelle part LOCATE Curated Protein Localization Annotations 1.0 null BMI1-23680149-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE227891_5_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null Hepatoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TW-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAXBP1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-A64985224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06583 abnormality of coagulation GWASdb SNP-Phenotype Associations 1.0 0.23209 small-subunit processome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.816 ATF3 ENCODE Transcription Factor Targets 1.0 null CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.68211 BRD-K56826759 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18022 GSE135514_2_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null 2546_EIF3CL_ENST00000380876.4,ENST00000398943.3,ENST00000398944.3 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.822259 1040_C1ORF131_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.726037 Nf1 Microdeletion Syndrome DisGeNET Gene-Disease Associations 1.0 null GTEX-X3Y1-0426-SM-3P5Z4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.854894 GTEX-UPK5-1426-SM-4JBHH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835445 Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.11669 NSFL1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2874 Brain Lower Grade Glioma_LGG_TCGA-VV-A86M-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7513_RPS24_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.679816 OLIG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2667 BRD-K11672894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82805 r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63306 H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE224547_1_v_0_cftr_human RummaGEO Gene Perturbation Signatures 1.0 null GSE258991_5_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XQ8I-1926-SM-4BOOK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970522 GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0854 GTEX-VJYA-0001-SM-3NMDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.36504 orbital frontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.039 BRD-K21996934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4107 GSE114992,GSE114993_4_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCIH2196 CCLE Cell Line Gene Expression Profiles -1.0 -2.30823 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.77258 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.851982 RERFLCSQ1 CCLE Cell Line Gene CNV Profiles 1.0 1.33647 GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles 1.0 1.5894 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.67208 Nephrotome TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.635 GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56487 hsa-miR-595 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 BRD-K00698280 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.21019 H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE149903_5_v_2_myd88_mouse RummaGEO Gene Perturbation Signatures -1.0 null Artemether_PANC-1 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0215257 A549_MC1568_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0138305 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54342 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33924 BRD-K35726223 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3102 ASAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1432 posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18227 peripheral nervous system neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.357077 GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16187 GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.573179 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158632_3_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null GSE168602,GSE168604_2_v_1_selumetinib_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF710 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33132 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42556 7505_RPS16_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.706414 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.882143 POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K88538240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23146 GSE164874_5_v_14_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null occipital cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16341 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null WDR74 Pathway Commons Protein-Protein Interactions 1.0 null H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239844_11_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-A54490075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03452 BRD-K09975619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58837 Neurofibroma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.094 abnormal leukocyte count GWASdb SNP-Phenotype Associations 1.0 0.395786 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null smooth muscle HPA Tissue Protein Expression Profiles -1.0 -2.14252 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31796953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31014 rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.927641 OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.272212 H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.54555 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NR4A2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1175 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-0326-SM-2XCBI GTEx Tissue Sample Gene Expression Profiles 1.0 0.976651 TAL1-21186366-BM-HSCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null liminal part of the r7 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.16421 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Male reproductive organ cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.88408 USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K82658511 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71188 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.265 CTCF_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleolus GO Cellular Component Annotations 2025 1.0 null H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null QB-35-FO29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.224398 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16049 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE152432_5_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE146982_7_v_5_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.84782 GSE180147_0_v_1_itga5_human RummaGEO Gene Perturbation Signatures 1.0 null Lateral reticular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20826 MYC-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K99650219 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18829 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09729 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Rucaparib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189961 CRCGN011_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7606 layer 1 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37518 CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63425 AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.556032 USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7923339-13046_2021_1884_MOESM7_ESM.xlsx-Overlap-3_UTR_lengthened_genes_in_CPSF6_KD_Huh7_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.12805 DMRTA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5006 Spinal nucleus of the trigeminal, oral part, middle dorsomedial part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04268 GSE159049_1_v_0_sox2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 2.32309 MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.42423 FLI1-21867929-TH2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AKT1_knockout_215_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.28491 GSE153836_11_v_9_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null RCOR2 Pathway Commons Protein-Protein Interactions 1.0 null GSE119564_2_v_3_zfp217_mouse RummaGEO Gene Perturbation Signatures -1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.58479 BRD-K68347834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0576 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null GSE228263_0_v_1_elesclomol_human RummaGEO Drug Perturbation Signatures -1.0 null FXYD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48239 LXR-22158963-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K32495578 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48534 GSE184892_0_v_5_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42377 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.43695 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882977 BRD-K86159732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.4473 CCDC85B Hub Proteins Protein-Protein Interactions 1.0 null 2-iminoacetate synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.972 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null metaphase_anaphase_telophase_60min_noscapine_release vs ctrl_HeLa (Human) [19691289] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs -1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06087 SW13 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE210885_0_v_1_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.901831 RIF1 Pathway Commons Protein-Protein Interactions 1.0 null UTP14A Pathway Commons Protein-Protein Interactions 1.0 null liver cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.79495 USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null isthmic roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57027 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE159473_0_v_1_eif5a2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.69905 POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUP85 Pathway Commons Protein-Protein Interactions 1.0 null H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158632_3_v_1_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K08190558 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30538 CTCF_astrocyte of the cerebellum_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-0526-SM-3DB8R GTEx Tissue Sample Gene Expression Profiles 1.0 1.20994 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.33684 CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28493 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3913 K562_Quercetin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162724 CRCGN013_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.96675 H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882977 SLC22A18 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00650173 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03094 A549_FLLL32_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176259 NUP93 Pathway Commons Protein-Protein Interactions 1.0 null GD-66-XE49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212216 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205163,GSE205164_2_v_0_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null 2321_DNTTIP2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.500473 MDA-MB-468 COSMIC Cell Line Gene Mutation Profiles 1.0 null Malignant mesothelioma of pleura_Pleura_GSE2549 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.67329 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.830528 GSE223908,GSE223909_1_v_6_serpinb3_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GATA1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.58442 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227592_6_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6493_PNO1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.510127 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 EEF1AKMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98657 primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25431 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAL1-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K92879007 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75262 GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.14032 NCI-H250 GDSC Cell Line Gene Expression Profiles 1.0 2.34439 H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE235017_1_v_0_uba52_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K21059010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54181 NEUROG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.296 CRCGN014_HEPG2_3H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11595 CRCGN016_MCF10A.WT.HP_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9177 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE140200_1_v_3_trim59_mouse RummaGEO Gene Perturbation Signatures -1.0 null r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.60664 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.053895 BRD-K39267096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10769 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDR_knockdown_119_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.85483 GSE258991_5_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Momelotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160337 CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.257 VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.850841 NCIH2444 CCLE Cell Line Gene CNV Profiles -1.0 -1.38833 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHA15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0666 CTCF_A549_hg19_10 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K91241684 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17497 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.40386 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.32807 GSE155162,GSE155169_1_v_0_buparlisib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1444 GSE213442_1_v_0_kpna2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-O5YU-0008-SM-4E3I7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.38891 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 10029_ZC3H8_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.621185 RSV_48Hour_22398282_GSE32138 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.08029 GIGYF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13248 Lung squamous cell carcinoma_LUSC_TCGA-68-A59J-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.962729 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.914597 BRD-K99971319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43645 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23698 H3K27ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.33089 r7 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14415 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.914838 GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37493 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.848329 MTMR6 Pathway Commons Protein-Protein Interactions 1.0 null SP2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K56889360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14207 ABC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.67975 Prostate adenocarcinoma_PRAD_TCGA-VP-A876-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r1 part of vestibular nucleus Y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0544 GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6097 BRD-K69791255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28202 KAP1-22055183-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null nf1 GeneRIF Biological Term Annotations 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H1105 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -6.07465 BRD-K63058274 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21635 ARID3A ENCODE Transcription Factor Targets 1.0 null GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null nocodazole-2076 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.93452 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-0226-SM-48FEI GTEx Tissue Sample Gene Expression Profiles 1.0 1.13279 BRD-K81995936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21732 AD-34-TG29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.22408 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31672963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14558 FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.320933 OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31999 K562_AC480_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.022823 r10 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12389 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.953165 GINS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36219 Skin TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CTCF ENCODE Transcription Factor Targets 1.0 null GTEX-OXRO-0011-R10A-SM-2I5EH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98101 CRCGN015_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.3357 ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE261563_0_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.343 GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.99662 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K24453679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34821 CRCGN015_MCF10A.WT.HP_24H:G18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0551 BRD-K71544970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.1884 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Apoptosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.093 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 heart muscle HPA Tissue Gene Expression Profiles -1.0 -0.884905 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Writing disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.315 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3977 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.945288 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null rRNA processing in the nucleus and cytosol Reactome Pathways 2024 1.0 null BRD-K05119275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25473 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GY-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4177363__F5 PFOCR Pathway Figure Associations 2024 1.0 null GSE168797_1_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-R55C-1926-SM-2TF4K GTEx Tissue Sample Gene Expression Profiles 1.0 1.02772 CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.97344 4147_INTS2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.601143 MYC ChEA Transcription Factor Targets 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A549_SL-327_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172472 7501_RPS13_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.771543 superficial stratum of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73164 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.48994 PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-Unnamed_1_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null A172 CCLE Cell Line Gene CNV Profiles 1.0 1.81273 ELK1 ENCODE Transcription Factor Targets 1.0 null SNU-638 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15655 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.907541 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSE-0011-R7A-SM-3P5YZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00948 BCL11A Pathway Commons Protein-Protein Interactions 1.0 null GSE111138,GSE111149_1_v_0_runx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null small-subunit processome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 2.05321 GSE143643,GSE143644_3_v_5_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K36me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K05127596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54208 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.4058 USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50575036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10172 Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.849213 K562_Ivosidenib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173683 GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 1.03272 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.876551 epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055781 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.04205 8229_SNRPD2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.899488 Pwp2p-containing subcomplex of 90S preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.162 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.30179 nuclear part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93543 CRCGN009_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03459 GTEX-X3Y1-0726-SM-3P5YU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89031 posterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.74954 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle part GO Cellular Component Annotations 2015 1.0 null GSE200673,GSE200691_2_v_4_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.561 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.83502 HEC-1-A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10176 COLO-792 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.04525 VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.875775 Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20437 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06842 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KIF13B Pathway Commons Protein-Protein Interactions 1.0 null KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0664 GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48046 Cell type cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HC-01-FD24_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.62755 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SLIK (SAGA-like) complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.607 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null anterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02113 CRCGN015_MCF10A_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.2073 GATA4 ChEA Transcription Factor Targets 1.0 null A549_BMS-911543_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016523 PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF Rummagene Transcription Factor Associations 2026 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A3JM-01A-12R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null PPARG-20887899-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVN-2226-SM-2S1PM GTEx Tissue Sample Gene Expression Profiles 1.0 1.16765 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.42087 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.704413 Lung adenocarcinoma_LUAD_TCGA-05-4418-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K17675523 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06547 PANX3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93614 SPTLC2 Pathway Commons Protein-Protein Interactions 1.0 null r9 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23627 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K44866331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07415 SQ1 CCLE Cell Line Gene CNV Profiles 1.0 1.75695 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PDGFRA_activemutant_54_GSE17743 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.48612 BRD-K44027058 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25417 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NCI-H23 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.80265 nucleus of the diagonal band, left, horizontal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.872529 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE189683_1_v_0_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Neurofibromatosis DisGeNET Gene-Disease Associations 1.0 null GSE145915_3_v_2_pcm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE185519_1_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906594 GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27194 GSE199543,GSE239447_0_v_4_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE167886_2_v_0_chd7_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.3955 CRCGN015_HEPG2_48H:D17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.89096 GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82158 GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836167 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43678 Histone acetyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.241 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20377 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7220-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membraneless organelle GO Cellular Component Annotations 2025 1.0 null BRD-K75595810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29561 primary auditory cortex (core)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.03358 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053916 GTEX-S32W-1526-SM-4AD6Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.11811 GSE198434_1_v_0_aspirin_human RummaGEO Drug Perturbation Signatures -1.0 null A549_Dasatinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150451 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null abnormality of neutrophils GWASdb SNP-Phenotype Associations 1.0 0.395786 EOMES-21245162-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU1196 CCLE Cell Line Gene Expression Profiles 1.0 1.42547 CCDC85B Pathway Commons Protein-Protein Interactions 1.0 null OLIG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4418 ETS1 ENCODE Transcription Factor Targets 1.0 null GTEX-OHPN-0011-R4A-SM-2I5FD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11607 GSE222047_0_v_1_imidazole_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KURAMOCHI CCLE Cell Line Gene CNV Profiles -1.0 -2.20977 Retrosplenial area, lateral agranular part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.7245 NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02723 FOS ENCODE Transcription Factor Targets 1.0 null AKAP8L Pathway Commons Protein-Protein Interactions 1.0 null ribosome biogenesis GO Biological Process Annotations 2025 1.0 null Perturb_3212_KD_CNOT3_SRP117693 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Reproductive system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 BRD-K34262858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17469 Perturb_4881_KD_TP53_SRP131666 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.38457 GSE191105_2_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null decamethonium LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24535 PMC5054126-mmc4.xls-SCX_Mascot-Protein_identification_by_Mascot_databse_search_from_SCX_fractionated_samples_SCX Rummagene Transcription Factor Associations 2026 1.0 null NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null 939_BYSL_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.572454 HEC50B CCLE Cell Line Gene Expression Profiles 1.0 2.5735 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dehydration_CNS - Brain - Hypothalamus (MMHCC)_GSE4130 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.23023 SW1990 CCLE Cell Line Gene Expression Profiles 1.0 1.35969 Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J7-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null No annotation - 5 CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66348 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.59787 Talus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.133 BRD-K43982279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35321 monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049408 mediodorsal nucleus of thalamus_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.89749 ribosomal small subunit biogenesis GO Biological Process Annotations 2025 1.0 null lateral septal nucleus, intermediate part, periventricular Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94052 BRD-K35383890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19717 7522_RPS2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.549227 A549_Zileuton_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0197757 EA-18-FP00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.334133 REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211128_3_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.1779 GSE202434,GSE202438_13_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null FOSL1::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.078 Enamel organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.145 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829968 GATA1_G1E-ER4_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_AG-14361_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209262 TFIP11 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K42016545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0483 STK40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51434 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null susceptible GeneRIF Biological Term Annotations 1.0 null VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.989062 CTCF_GM12801_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DUX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.2667 CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null A-VN-1203-2004(H5N1)_Day2-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.82267 HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.246 TAL1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Tacedinaline_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0224733 RBM34 Pathway Commons Protein-Protein Interactions 1.0 null K562_Glesatinib(MGCD265)_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209833 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54719 BRD-K19800225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12883 TIMM8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55384 BB65-RCC Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.70215 RXRA ENCODE Transcription Factor Targets 1.0 null BD-69-XG81_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.380607 GTEX-S32W-1626-SM-4AD6G GTEx Tissue Sample Gene Expression Profiles 1.0 0.917464 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36944 Organelle lumen COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09701 ELK1-19687146-Hela cells-human ChEA Transcription Factor Binding Site Profiles 1.0 null H4K20me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null tonsil_8b1 HPA Tissue Sample Gene Expression Profiles 1.0 1.3088 BRD-K16079077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69051 A549_Alisertib_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142832 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2950-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K12612468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01726 SIN3A_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null abnormality of the common coagulation pathway GWASdb SNP-Phenotype Associations 1.0 0.777194 NANOG ChEA Transcription Factor Targets 1.0 null dorsolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02674 RERFLCAI CCLE Cell Line Gene CNV Profiles -1.0 -1.52352 GSE110440_1_v_3_rad21_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A.TP53.M_24H:F22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1456 H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4288 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K82477786 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01107 GTEX-U3ZH-0226-SM-3DB7B GTEx Tissue Sample Gene Expression Profiles 1.0 0.879151 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MITF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28411 GSE164757,GSE164759_4_v_2_trametinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null shsy5y HPA Cell Line Gene Expression Profiles -1.0 -0.858403 spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14713 RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2508 7537_RPS7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.725102 CEBPB-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -2.31188 OSBPL1A Pathway Commons Protein-Protein Interactions 1.0 null ZNF282 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3884 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.29761 H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K22478004 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36334 YAP1 ChEA Transcription Factor Targets 1.0 null preribosome GO Cellular Component Annotations 2015 1.0 null BRD-K52259096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46661 GSE179974_3_v_1_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null XAB2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE114992,GSE114993_9_v_6_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null TAL1_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X261-0011-R6B-SM-4E3J8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24091 7608_RUVBL2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.676508 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3858 mRNA_NIPBL_20720539 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null LHX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8271 Lateral visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13381 CAL-33 GDSC Cell Line Gene Expression Profiles -1.0 -3.394 GTEX-UJMC-1926-SM-3GADS GTEx Tissue Sample Gene Expression Profiles 1.0 0.953548 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95147720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55185 GSE196699_0_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888327 pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.37369 7424_RPAP3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.566912 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.932211 H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles 1.0 1.51339 HDAC1 ENCODE Transcription Factor Targets 1.0 null GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles 1.0 1.91016 PIKFYVE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18713 SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE166783_1_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null nucleic acid metabolic process GO Biological Process Annotations 2015 1.0 null GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1377 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K94145457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35206 8184_SMN2_ENST00000380743.4 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.697646 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7154-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r7 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23238 mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.47521 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06276 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04518 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135514_8_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0559 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.887767 Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TIMELESS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.009 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A549_GSK J1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0120071 GTEX-UJMC-0008-SM-4IHKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.14912 Box H/ACA RNP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.918 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WHPG-0004-SM-3NMDO GTEx Tissue Sample Gene Expression Profiles 1.0 1.42059 GTEX-WYBS-1226-SM-3NM9N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.978598 LD-69-ZV56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209809 PMC5642521-oncotarget-08-69847-s004.xls-Sheet1-List_of_down_regulated_genes_in_NRF2_KD_A549_cells_FC_1_5_AR Rummagene Transcription Factor Associations 2026 1.0 null V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.954071 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S32W-1226-SM-4AD67 GTEx Tissue Sample Gene Expression Profiles 1.0 0.880708 dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04304 GTEX-XMK1-0326-SM-4B652 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944793 BRD-K35119180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.081 BRD-K59239787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30406 fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE186707_1_v_0_hdac4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE198165,GSE198166_7_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05472 GSE182680,GSE182683_0_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-2026-SM-48TDE GTEx Tissue Sample Gene Expression Profiles 1.0 0.83577 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11711 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A_48H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11834 outer CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.95785 GTEX-POYW-1326-SM-48TCG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.897408 GSE206516,GSE206518_6_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182854_2_v_0_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null NR1H3 ChEA Transcription Factor Targets 1.0 null CTCF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1563 CCLE Cell Line Gene CNV Profiles 1.0 2.17838 2988_FBL_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.597376 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041857 MAX ENCODE Transcription Factor Targets 1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IL15RA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00588459 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.509691 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139016_0_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures -1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GR MotifMap Predicted Transcription Factor Targets 1.0 null USP53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01277 MAZ ENCODE Transcription Factor Targets 1.0 null GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.24399 PARP MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K73479560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82205 DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2819 BRD-K54650634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81463 BRD-K47028303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63754 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_PF-573228_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189115 KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.847198 GSE110440_2_v_0_rad21_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-3792-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.211 amygdaloid complex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.48884 POLR2A_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ARID3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02139 Lung adenocarcinoma_LUAD_TCGA-05-5425-01A-02R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterolateral visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35869 BRD-K09454191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51249 CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06388 CEBPB ENCODE Transcription Factor Targets 1.0 null K562_Celecoxib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.019193 BRD-K65399214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56353 GSE200839,GSE233826_3_v_6_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.43965 BRD-K07009788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01739 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_AICAR_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142954 GSE228181_2_v_5_idh1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYCBP2 Pathway Commons Protein-Protein Interactions 1.0 null r3 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00356 PHF8 ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Motesanib Diphosphate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0199854 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K12336887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.16017 liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.957744 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.21038 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975293 90S preribosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 K562_Fluorouracil_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148425 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.97228 inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.904687 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles 1.0 1.0949 1774_COPG1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 3.50597 SYT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21399 7536_RPS6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.567372 CTCF_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6441-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE86507,GSE86509_7_v_2_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE199644_3_v_1_palmitic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null BMI1-23680149-NPCS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null A549_AZD1480_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0208137 ribonucleoprotein complex GO Cellular Component Annotations 2015 1.0 null COLO678 CCLE Cell Line Gene CNV Profiles 1.0 2.32688 YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_7583_KO_MBD6_SRP360138 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 12.8932 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.849972 POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:O13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.51166 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GEMIN2 Pathway Commons Protein-Protein Interactions 1.0 null A549_Ruxolitinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148431 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_12_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01426 periventricular stratum of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25078 H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Integument TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.847198 GSE168602,GSE168604_2_v_6_selumetinib_human RummaGEO Drug Perturbation Signatures -1.0 null GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE184892_6_v_1_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null A549_Alisertib_100nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0185678 IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.555725 CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles 1.0 1.48071 TTC27 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K90359063 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31327 OLIG3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5469 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC3153 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.560615 GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.487202 1083_NEPRO_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.765004 ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.349863 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Reproductive organ cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96246 Indacaterol (maleate)_A498 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0231739 intracellular part GO Cellular Component Annotations 2015 1.0 null CRCGN012_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31927 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE113734_1_v_0_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K00907050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1137 G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31999 GTEX-X15G-0526-SM-3NMB7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0892 CRCGN017_MCF10A.WT.HP_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6072 A549_TMP195_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161814 paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.874631 E2F6 ENCODE Transcription Factor Targets 1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.82474 TCF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22761 H3K27ac_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null small_intestine BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.932169 GSE206516,GSE206518_0_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null PMC11955568-41467_2025_57429_MOESM9_ESM.xlsx-Data_S7-JUN_OIS_Martinez2020_JUN Rummagene Transcription Factor Associations 2026 1.0 null d2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.589 PMC11093744-41592_2024_2172_MOESM3_ESM.xlsx-ELP-genes_NR5A1 Rummagene Transcription Factor Associations 2026 1.0 null posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47715 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H1_BMP4_Derived_Mesendoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.05698 abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.9936 A549_Lomustine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0205707 AKT2_knockdown_44_GSE12291 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.74281 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null leukopenia GWASdb SNP-Phenotype Associations 1.0 0.776085 GTEX-WEY5-0426-SM-3GIKT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38892 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10941 FLI1 ENCODE Transcription Factor Targets 1.0 null A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.02421 BRD-A71590475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06665 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPARG-20176806-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41717 BRD-K42809349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10624 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SG-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.36205 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-4J-AA1J-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.234 9253_TRAPPC8_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.13634 BRD-K01296372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82944 A549_Luminespib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0186935 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dorsal part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.039 NUP133 Pathway Commons Protein-Protein Interactions 1.0 null JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-0126-SM-4B65S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848324 MZ2-MEL GDSC Cell Line Gene Expression Profiles 1.0 1.53672 BRD-K92520489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21523 BRD-K48235533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17793 MPV17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3823 HT29 BioGPS Cell Line Gene Expression Profiles 1.0 1.17846 LUZP1-20508642-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null K562_Disulfiram_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0203565 GSE48812_2_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null nucleus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 CHRNG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00563984 FBXL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06049 REST_PFSK-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_10_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null A549_Givinostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149696 BRD-K15602285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1706 GSE173232_1_v_0_sf3b1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles 1.0 1.15739 BRD-K69564473 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14319 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PD-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 GTEX-W5X1-2326-SM-3GIL6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.975214 UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5489 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.17861 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MV-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHOX2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9417 retina BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.33364 17676974-TableS1 GeneSigDB Published Gene Signatures 1.0 null K562_KW-2449_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151768 P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 1.70558 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BCKDHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41875 testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.72439 k562 HPA Cell Line Gene Expression Profiles 1.0 1.16877 GSE184479_1_v_2_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SK-MEL-5 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112765,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37052 GTEX-OXRL-0326-SM-2I3F2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941756 MAX_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 K562_XAV-939_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180802 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K45713337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59922 TNFRSF8 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6144 GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32335 GSE182680,GSE182683_7_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877764 GSE71491_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.45034 CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB33 ENCODE Transcription Factor Targets 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5K5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10761381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33025 PC-14 GDSC Cell Line Gene Expression Profiles -1.0 -2.20618 GTEX-XGQ4-0326-SM-4GIEE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.964061 medial part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26969 PMC4051124-1471-2164-15-256-S15.XLSX-WES_IPD-RBCK1_1-Target_RBCK1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.24875 FLOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01 ATP6V1F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03628 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EOL1 CCLE Cell Line Gene Expression Profiles 1.0 1.74997 GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.302947 BRD4-27068464-CHIP-SEQ-AML-CELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null periventricular stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3212 GTEX-POYW-1126-SM-48TCI GTEx Tissue Sample Gene Expression Profiles 1.0 1.12948 GSE192513,GSE192515_2_v_0_atg16l1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ADIPOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44085 CRCGN010_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21025 A549_Panobinostat_10nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0128637 HT1080 BioGPS Cell Line Gene Expression Profiles 1.0 2.39002 CRCGN012_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.25839 GSE43041,GSE43044_0_v_1_ldb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0862 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.880415 Hinge joint TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.171 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE215155_0_v_1_golph3_human RummaGEO Gene Perturbation Signatures -1.0 null primary auditory cortex (core)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.5409 GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 0.95141 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r6 part of spinal trigeminal nucleus, pars oralis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37345 RHOXF2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T2YK-0326-SM-4DM7D GTEx Tissue Sample Gene Expression Profiles 1.0 0.916592 GTEX-XQ8I-1726-SM-4BOQB GTEx Tissue Sample Gene Expression Profiles 1.0 1.40268 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.877947 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BL-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Retrosplenial area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16401 KLK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24987 GTEX-WH7G-0326-SM-3NMBH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0459 autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.050976 CRCGN014_HEPG2_3H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.08355 EGR1 ENCODE Transcription Factor Targets 1.0 null yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.364142 9686_UTP3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.673146 CRCGN015_MCF10A_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6112 Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33936 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null capan2 HPA Cell Line Gene Expression Profiles -1.0 -1.06495 Saos-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.42614 GSE206870,GSE206872_4_v_2_ascl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287979 Sensorimotor area TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.624 outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.962842 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic_Islets Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.29484 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K35429158 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78766 GSE217552_3_v_0_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K32071534 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15813 GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.998029 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF3 ENCODE Transcription Factor Targets 1.0 null CMAH_KO_GDS4770_420_mouse_muscle GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K59130962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15212 SDHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45713 mantle zone of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41819 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925944 NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.91842 cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null outer CP in (rostral) midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0969 GSE182680,GSE182683_0_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.370084 HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1204 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Clevudine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150221 RDH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26183 GTEX-PX3G-0826-SM-48TZS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06683 RXRA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835832 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF3C2 ENCODE Transcription Factor Targets 1.0 null GSE261563_9_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-P6-A5OG-01A-22R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39568 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048695 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A7-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Vortioxetine_PANC-1 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00352079 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MEL cell line_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1-19687146-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25137 GSE205730,GSE205731_2_v_0_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null RCN2 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3210_KD_CNOT3_SRP117693 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HS852T CCLE Cell Line Gene Expression Profiles -1.0 -1.75805 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.033644 H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K45537529 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11251 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.960754 DDX20 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70635 LPAR2 Pathway Commons Protein-Protein Interactions 1.0 null TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.685563 LASP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42557 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null gemcitabine_homo sapiens_gpl96_gse6914 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7203 central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.51751 Cytosolic ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.293 RCOR1 ChEA Transcription Factor Targets 1.0 null CRCGN013_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28892 Primary visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01181 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4693 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CACNA1A Pathway Commons Protein-Protein Interactions 1.0 null SMC3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.88417 7522_RPS2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.596411 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.853311 GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.844214 Medial pretectal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2601 SW962 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.93031 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.019 r1 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08358 periventricular stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00009 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01646 GTEX-QV31-0126-SM-447BP GTEx Tissue Sample Gene Expression Profiles 1.0 1.04091 SOX6-21985497-MYOTUBES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26542 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GF1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null r10 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00435 BRD-K61660466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0169 Large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.403 lateral parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.986627 DDX6 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K92022897 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11698 GTEX-XOTO-0011-R9A-SM-4GICI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34844 GTEX-O5YW-0326-SM-2I5EI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45721 SNU119 CCLE Cell Line Gene CNV Profiles -1.0 -2.3583 BRD-K05475322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4347 CTCF_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.299283 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOT4-0326-SM-4B66S GTEx Tissue Sample Gene Expression Profiles 1.0 1.47567 GSE148692,GSE148695_5_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41717 GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0367 colon HPA Tissue Protein Expression Profiles 1.0 1.06485 BRD-K92736140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06846 GTEX-XUW1-1726-SM-4BOOZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.086 NCI-H292 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-W5X1-2826-SM-3GILM GTEx Tissue Sample Gene Expression Profiles 1.0 0.984822 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MED23 Pathway Commons Protein-Protein Interactions 1.0 null mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.8353 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X5-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1_G1E-ER4_mm9_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBL1XR1 Pathway Commons Protein-Protein Interactions 1.0 null Flp-In-T-REx cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.803 CRCGN012_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1578 Lung adenocarcinoma_LUAD_TCGA-95-7043-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE74251_2_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null nuclear part GO Cellular Component Annotations 2015 1.0 null BRD-K34456337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35709 GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles 1.0 1.16384 Nuclear pore outer ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.909 PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K67337799 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3861 Perturb_2854_Mut_PIK3CA_SRP404927 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K84570482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06208 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNRNPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07536 NCI-H838 GDSC Cell Line Gene Expression Profiles 1.0 1.59357 GSE206729_3_v_1_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.917656 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Tie2 kinase inhibitor_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.017782 REC1 CCLE Cell Line Gene Expression Profiles 1.0 1.47539 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.951444 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H446 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.94775 NCI-H2810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.75907 small-subunit processome GO Cellular Component Annotations 2023 1.0 null CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RN64-0626-SM-2TC5V GTEx Tissue Sample Gene Expression Profiles 1.0 0.831925 Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.98162 GSE137818_2_v_6_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17125 imatinib_homo sapiens_gpl96_gds3049 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE145790_0_v_1_bruceantin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null harmine-5855 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_ZM 447439_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158207 17254359-AddFile1 GeneSigDB Published Gene Signatures 1.0 null MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46171 BRD-K14756138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66862 heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.054348 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K18462967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42688 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K17708304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52666 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.26904 CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6283 primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.973773 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE242290_3_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null neurofibroma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.9839 GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49077 outer CP in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.70501 ROCK2_knockdown_157_GSE34769 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.957 BRD-K29392777 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28608 CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21534 GATA4-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SA-32-CC58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.371919 liver HPA Tissue Protein Expression Profiles -1.0 -1.22028 hsa-let-7b-5p MiRTarBase microRNA Targets 1.0 null GSE182680,GSE182683_7_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null orbital frontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.884031 GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34473 CRCGN016_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.81056 ChIP_POU5F1_16518401 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null AD-51-FB60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.492274 GSE184884_6_v_5_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE182680,GSE182683_7_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.274945 H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A02612852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18917 CRCGN014_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.77705 BRD-K53768630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.06781 BRD-K90625628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64645 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34773 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCIAML2 CCLE Cell Line Gene Expression Profiles 1.0 1.56901 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42249 NECTIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00047 MYEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30924 H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-UPK5-2026-SM-4JBIM GTEx Tissue Sample Gene Expression Profiles 1.0 1.90279 BRD-K51787437 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36124 EOMES-21245162-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles 1.0 1.579 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89168 SK-GT-2 COSMIC Cell Line Gene CNV Profiles 1.0 2.93899 PMC11184788-40164_2024_526_MOESM4_ESM.xls-MSC-EV_proteins-Unnamed_4_MSC Rummagene Transcription Factor Associations 2026 1.0 null Rkip1_KO_GDS4331_15_mouse_C57BL/C pancreas GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null fasciola cinerea Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41759 BRD-K22510845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01343 GSE136622_2_v_3_srpk3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.854951 BRD-K41532285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17397 ventral tegmental area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45724 hsa-miR-3163 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE207978_1_v_0_rai1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.512862 ARID1A Pathway Commons Protein-Protein Interactions 1.0 null SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K19734887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05968 BRD-K85641667 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08156 GB-73-QS80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.545179 intracellular organelle GO Cellular Component Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GS-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chromosome GO Cellular Component Annotations 2025 1.0 null GTEX-WH7G-0826-SM-4LVMR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03855 AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29183 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72842159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19448 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null IRF4_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV MA15_Day4_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.88394 K562_Momelotinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0202283 WRNIP1 ENCODE Transcription Factor Targets 1.0 null LBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8434 Metabolism of RNA Reactome Pathways 2024 1.0 null PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-RNA-Seq_analysis_of_genes_associated_with_a_DHS_that_has_a_CEBPAx2_specific_Hi-C_interaction_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null CRCGN017_MCF10A.TP53.M_24H:J04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.70615 cho cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.591641 GSE240896,GSE240899_3_v_0_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.48838 PMC10882188-ADB-29-e13365-s002.xlsx-ST18-Unnamed_8_ST18 Rummagene Transcription Factor Associations 2026 1.0 null GSE234647_1_v_3_regorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 PC-68-DU31_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225055 CTCF_GM12870_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null amiloride-1470 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE210655_1_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-638 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.35172 H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GSE223893_1_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0078 harmol-7320 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NANOG-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.18963 GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09729 SNU869 CCLE Cell Line Gene CNV Profiles 1.0 2.57439 GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.888121 SIGM5 CCLE Cell Line Gene Expression Profiles 1.0 1.79895 intracellular organelle part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 C4BPB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00528681 BRD-K41410736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54876 ELK1 ChEA Transcription Factor Targets 1.0 null BRD-K71141540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08541 HCFC1 ENCODE Transcription Factor Targets 1.0 null CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null K562_AG-14361_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158566 HMGN3 ENCODE Transcription Factor Targets 1.0 null H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A913-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7312_RIOK2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.591484 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149355_0_v_1_esrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43479 CRCGN017_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.31642 HC-74-HM63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.24886 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC_INHIBITION - trichostatin A_GDS2452_709_human_Endothelial cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5893-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE63048_11_v_12_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE102505_6_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null Cytosolic small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.362 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.8082 CTCF_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARHGAP35 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K26435104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35825 GSE182680,GSE182683_0_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28653 H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 4108_IMP4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.646835 Nucleus y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02145 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.915624 cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.42098 IGF2BP3 Pathway Commons Protein-Protein Interactions 1.0 null ADNP Pathway Commons Protein-Protein Interactions 1.0 null EIF4ENIF1 Pathway Commons Protein-Protein Interactions 1.0 null OSU-03012 DeepCoverMOA Drug Mechanisms of Action -1.0 -1.12 EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Maraviroc_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0202244 CTCF_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PROX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6316 orbital frontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.934968 r9 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17216 Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB33_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-1526-SM-4BRWB GTEx Tissue Sample Gene Expression Profiles 1.0 1.28181 Peripheral nerve sheath neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.989 hsa-miR-4327 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GTEX-WH7G-1726-SM-4LVKY GTEx Tissue Sample Gene Expression Profiles 1.0 0.886144 internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null icSARS-Cov_Day1_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.66808 RBM14 Pathway Commons Protein-Protein Interactions 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049952 CHD2 ENCODE Transcription Factor Targets 1.0 null GSE227127_1_v_0_diclofenac_human RummaGEO Drug Perturbation Signatures -1.0 null GSE125782_0_v_2_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41819 PC-3_[JPC-3] Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.24081 GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76283 NCI-H630 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.54119 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.65383 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83143868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57794 BHLHE23 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5606 BECKER CCLE Cell Line Gene CNV Profiles -1.0 -2.66788 GSE218060_2_v_6_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE111247_14_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null A375 GDSC Cell Line Gene Expression Profiles 1.0 1.46487 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null imatinib_homo sapiens_gpl96_gds3045 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SLC25A45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31663 r7 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.3813 BRD-K28159131 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08922 GTEX-RUSQ-0126-SM-47JWV GTEx Tissue Sample Gene Expression Profiles 1.0 0.890297 GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21433 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RASopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.001 A549_A-366_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151537 TRIM28 ENCODE Transcription Factor Targets 1.0 null Perturb_9812_KD_CNOT3_SRP117693 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.30783 BRD-K24722502 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18193 outer CP in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.99667 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.40237 NUP98 Pathway Commons Protein-Protein Interactions 1.0 null DNTTIP2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-V955-2526-SM-4JBJG GTEx Tissue Sample Gene Expression Profiles 1.0 0.843262 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CB-83-LF14_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.205688 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.947272 layer 1 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.05971 FOXA2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-X6-A7WB-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE86507,GSE86509_7_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE88819_1_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.217352 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YLPM1 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.201962 CRCGN017_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3103 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54786 GSE136894_1_v_3_psen1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Learning disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.686 Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.78426 orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.31146 Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE57871_6_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE48812_11_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SB-09-JU93_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245486 PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 0.896903 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE152699,GSE152723_0_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures -1.0 null SMC1A Pathway Commons Protein-Protein Interactions 1.0 null HNF1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9481 CTCF_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_3208_KD_CNOT3_SRP117693 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.60513 GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.75172 DNLZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94159 posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.848556 CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paragigantocellular reticular nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83848 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null NFE2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08911 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.55593 AA-43-BW50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.372125 mantle zone of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27062 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11839 BRD-K34931072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66366 hsf1_17216044_hela_lof_human_gpl571_gds1733 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.063199 intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 PWP2 Hub Proteins Protein-Protein Interactions 1.0 null GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.55886 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22905 dorsal raphe nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.979184 GSE242290_1_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.29565 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.961832 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.27847 COV413A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24443 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2 ENCODE Transcription Factor Targets 1.0 null NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.6793 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.06748 haploinsufficiency GeneRIF Biological Term Annotations 1.0 null GTEX-QEG5-0326-SM-2S1PB GTEx Tissue Sample Gene Expression Profiles 1.0 0.862267 RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null salivarygland_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.25902 BRD-K48738035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11224 CTCF_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AH-0326-SM-48U1K GTEx Tissue Sample Gene Expression Profiles 1.0 0.877048 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KU812 CCLE Cell Line Gene CNV Profiles -1.0 -1.99265 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.1484 MCF7 BioGPS Cell Line Gene Expression Profiles -1.0 -1.75708 GTEX-V1D1-0003-SM-3NMDP GTEx Tissue Sample Gene Expression Profiles 1.0 0.88477 GRHL2-25758223-PLACENTA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K15647573 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28976 UACC-893 COSMIC Cell Line Gene Mutation Profiles 1.0 null STAT1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7116212__F6 PFOCR Pathway Figure Associations 2023 1.0 null appendices_4c HPA Tissue Sample Gene Expression Profiles 1.0 1.21279 Prostate carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142684_3_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null nucleolus GeneRIF Biological Term Annotations 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF684 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.5314 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46986 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17246 ATF2 ENCODE Transcription Factor Targets 1.0 null GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.00358 GATA1_G1E-ER4_mm9_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.888017 GSE112365_0_v_1_sirt1_human RummaGEO Gene Perturbation Signatures -1.0 null nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EP-0726-SM-3P5YJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.979946 PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050415 amygdaloid complex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14485 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.40525 BRD-K13122526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22143 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE103068_0_v_1_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.851319 GSE245270_1_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37487 GSE157233_2_v_4_a1cf_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nodulus (X), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38867 molecular layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.874667 PMC7285791__F4 PFOCR Pathway Figure Associations 2023 1.0 null MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null RPLP0 Hub Proteins Protein-Protein Interactions 1.0 null GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78679 Lung squamous cell carcinoma_LUSC_TCGA-90-7767-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058713 BRD-K34602185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36292 BRD-K24585433 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51737 cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null spleen GTEx Tissue Gene Expression Profiles 1.0 1.11063 POLR2A ENCODE Transcription Factor Targets 1.0 null ETV2::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.6749 BRD-K87205390 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0135 TAL1_erythroblast_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234637_1_v_0_ikzf1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18333 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.935783 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049419 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null CRCGN010_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11984 ZFR Pathway Commons Protein-Protein Interactions 1.0 null carbenoxolone-3353 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE172295_0_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9034 CTCF_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE115542_2_v_3_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null A549_Fedratinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0207901 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE229671,GSE229673_2_v_1_yrdc_human RummaGEO Gene Perturbation Signatures -1.0 null PMC11103890-mmc3.xlsx-ZZZ3_interactors_ESC-1-Gene_names_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null ovary TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070539 WDR36 Pathway Commons Protein-Protein Interactions 1.0 null PPP6R3 Pathway Commons Protein-Protein Interactions 1.0 null VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19451 NR2F2 ENCODE Transcription Factor Targets 1.0 null CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.84865 BRD-K09203354 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14635 motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.858441 Large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Protein phosphatase type 1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.779 GSE140322_3_v_1_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null HT29 CCLE Cell Line Gene CNV Profiles 1.0 1.73196 dobutamine-1589 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Asciminib_PANC-1 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0293836 BRD-K34088127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24316 KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.335079 CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-0626-SM-2XCF6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40401 GTEX-POYW-0426-SM-2XCEV GTEx Tissue Sample Gene Expression Profiles 1.0 2.24127 PMC10746608-427_2023_709_MOESM5_ESM.xlsx-SOX2_partners-SOX2_known_protein_partners_according_to_BioGrid_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03455 leukopenia GWASdb SNP-Disease Associations 1.0 0.400169 BRD-K13781734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00023 largeintestine BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.13714 GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68225 BRD-K27331198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13042 GSE111247_14_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5341 Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61404 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null heterocycle metabolic process GO Biological Process Annotations 2015 1.0 null 8205_SNAPC1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.512449 GSE209601_2_v_1_mef2a_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1012-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135514_2_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.892133 amygdaloid complex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.50795 GTEX-WFJO-0002-SM-3P61X GTEx Tissue Sample Gene Expression Profiles 1.0 1.63912 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endoplasmic reticulum LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K66278562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31366 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K18452866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72806 HNF1A Pathway Commons Protein-Protein Interactions 1.0 null BRD-K88135858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65916 KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.324586 BRD-K63829331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2078 snoRNA binding GO Molecular Function Annotations 2025 1.0 null Bladder squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.51 GSE189609_1_v_2_hax1_human RummaGEO Gene Perturbation Signatures -1.0 null ARGFX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1806 BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.305825 7509_RPS19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.569868 K562_MK-5108_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0271772 lateral trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77606 sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09441 BRD-K13241788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87858 POU5F1-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null MTREC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.036 HCC1833 CCLE Cell Line Gene Expression Profiles -1.0 -1.5444 GSE173810_0_v_3_igf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles 1.0 1.10713 GSE214823,GSE214824_0_v_2_crtc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC6591464-Table_4.xlsx-Sheet_1-Non-AIRE_regulated_genes_random_set_1_AIRE Rummagene Transcription Factor Associations 2026 1.0 null Retrosplenial area, ventral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08827 CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.970447 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K11027431 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.36474 non-membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 BAZ1B Pathway Commons Protein-Protein Interactions 1.0 null Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1723 Lung squamous cell carcinoma_LUSC_TCGA-22-5480-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.973455 GTEX-WHSE-0011-R3A-SM-3P5ZM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27274 Peroxisomal importomer complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.736 Brequinar DeepCoverMOA Drug Mechanisms of Action -1.0 -1.9 r6 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00568 A549_AICAR_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178131 GTEX-XPVG-0826-SM-4B654 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20243 RXF393 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.30799 ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 1083_NEPRO_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.511985 BRD-K28036658 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01235 GSE226249_5_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6493_PNO1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.644844 GSE258991_5_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K93130549 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13457 IRF4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12795 mantle zone of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16461 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.26373 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2343 EBF1 ENCODE Transcription Factor Targets 1.0 null superficial stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75186 Retrosplenial area, lateral agranular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71028 A549_Ramelteon_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184149 CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV5 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE136622_7_v_3_srpk3_mouse RummaGEO Gene Perturbation Signatures 1.0 null REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 2.36137 intracellular organelle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.068526 5902_NUP88_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.519353 ZBTB7C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5617 OVKATE CCLE Cell Line Gene CNV Profiles -1.0 -1.37435 GABP-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.828371 imatinib_homo sapiens_gpl96_gds3042 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K70518736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0993 HSF4 Pathway Commons Protein-Protein Interactions 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.75921 GTEX-XAJ8-1126-SM-47JYA GTEx Tissue Sample Gene Expression Profiles 1.0 0.837373 GTEX-OIZG-1126-SM-2HMIU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08419 PC-18-VX23_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208088 POU5F1 ChEA Transcription Factor Targets 1.0 null Primary somatosensory area, trunk, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.327 Disease of cellular proliferation DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 CRCGN008_HEPG2_24H:F24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0807 amygdaloid complex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34423 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PHIP Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4582-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular metabolic process GO Biological Process Annotations 2015 1.0 null Congenital heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.384 caffeic acid-5352 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE163282_12_v_8_aspirin_human RummaGEO Drug Perturbation Signatures 1.0 null 2226_DIMT1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.51002 CRCGN015_MCF10A_48H:F02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4676 mantle zone of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37724 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.00877 pwp2p-containing subcomplex of 90s preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.98906 choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.70808 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2223 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_Nintedanib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154868 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null requires GeneRIF Biological Term Annotations 1.0 null GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null bergapten LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.34756 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SPI1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F3 Pathway Commons Protein-Protein Interactions 1.0 null GSE206516,GSE206518_5_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.541854 intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE135350_2_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.55246 RAD21_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.899493 Carcinoma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K11518913 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09879 CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null A549_Tucidinostat_100nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156111 Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48873 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPZ Pathway Commons Protein-Protein Interactions 1.0 null periventricular stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08652 BRD-K50726251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31862 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K32706281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68098 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.2692 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09553 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AF-01-FE42_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.498663 GTEX-XMD1-0011-R2B-SM-4AT5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12642 GSE207787_1_v_2_pdha1_human RummaGEO Gene Perturbation Signatures -1.0 null Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40527 GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32034 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7017 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882977 ventrolateral periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66096 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null BDH1 Pathway Commons Protein-Protein Interactions 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 0.941274 CRCGN012_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03608 WDR33 Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07493 GSE171179,GSE171181_0_v_1_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.850042 GSS CCLE Cell Line Gene CNV Profiles 1.0 1.36195 deferasirox_homo sapiens_gpl570_gds3558 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Epithelioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80036 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.96908 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE119498_0_v_7_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85184 CTCF_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE185519_4_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null thp1 HPA Cell Line Gene Expression Profiles 1.0 1.00849 RUNX1 Pathway Commons Protein-Protein Interactions 1.0 null EEF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.006005 gammatubulin GeneRIF Biological Term Annotations 1.0 null DL-thiorphan-2752 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.8287 HSD17B12 Pathway Commons Protein-Protein Interactions 1.0 null ZNF652 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0313 GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.22042 GTEX-NL4W-0011-R11A-SM-2I3DW GTEx Tissue Sample Gene Expression Profiles 1.0 1.28083 Prostate adenocarcinoma_PRAD_TCGA-HC-A632-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles 1.0 0.916019 H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE140607_3_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17291 testis_7b HPA Tissue Sample Gene Expression Profiles 1.0 0.925057 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8277 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.94168 PU.1-20513432-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PARP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56906 BRD-K88890050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96067 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.862589 H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TK10 BioGPS Cell Line Gene Expression Profiles -1.0 -1.34565 USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC4A7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64215 GSE152246_0_v_1_dihydrotestosterone_human RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.838539 small nucleolar ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.742318 SIN3A_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K80950551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96079 Brain Lower Grade Glioma_LGG_TCGA-TM-A84I-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles 1.0 1.82055 CAD Pathway Commons Protein-Protein Interactions 1.0 null striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.51505 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5740-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null K562_MK-0752_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187528 irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.789158 carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE125782_3_v_2_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-R45C-0926-SM-3GAD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0681 NCOR-22424771-293T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEC108 CCLE Cell Line Gene CNV Profiles -1.0 -1.64631 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46087 HDMYZ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.6649 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null colon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KPNYN CCLE Cell Line Gene CNV Profiles -1.0 -1.47232 intracellular non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null Sarcoma_SARC_TCGA-LI-A67I-01A-31R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE172295_3_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7204 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38996 Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11003700-pbio.3002240.s018.xlsx-GOBP_NCRNA_PROCESSING-Unnamed_1_ATOH7 Rummagene Transcription Factor Associations 2026 1.0 null nuclear part LOCATE Curated Protein Localization Annotations 1.0 null Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null preribosome, small subunit precursor COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.355 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH2444 CCLE Cell Line Gene Expression Profiles -1.0 -1.49921 OE33 GDSC Cell Line Gene Expression Profiles 1.0 1.68812 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCI-AML2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.33011 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FBXL19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40596 GSE159893_2_v_0_genistein_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE98964_1_v_4_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21849 layer 2 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03717 GSE179031_3_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PAX5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LMO2-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NO-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Retrosplenial area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07236 GSE93156_1_v_0_idelalisib_human RummaGEO Drug Perturbation Signatures -1.0 null HEATR1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9883165-41375_2022_1744_MOESM4_ESM.xlsx-CEBP_gene_module-Unnamed_1_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Quercetin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137946 H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -2.17529 GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.910262 CRCGN015_HEPG2_48H:E22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.76421 GATA1_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.88022 EPS8L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28741 r9 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36878 NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7150-01A-21R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.956898 RCOR1 ENCODE Transcription Factor Targets 1.0 null breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.052734 Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.588498 90s preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.91604 GTEx Uterus 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 3.78933 r6 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07686 Alzheimer's Disease_CNS - Brain - Hippocampus (MMHCC)_GSE1297 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.40038 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.825225 BRD-K34929471 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62088 SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.8757 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-1626-SM-3LK5F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06828 BEN GDSC Cell Line Gene Expression Profiles -1.0 -1.74896 GSE210101,GSE210114_2_v_10_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24879 HCC1897 CCLE Cell Line Gene Expression Profiles -1.0 -1.63333 H3K36me3_splenic B cell_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12525 Cellular anatomical entity COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 LCLC103H_LUNG CCLE Cell Line Proteomics 1.0 2.18518 PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D14__TRANS-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null ncrna processing GO Biological Process Annotations 2015 1.0 null DDX27 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USP7 Hub Proteins Protein-Protein Interactions 1.0 null BRD-K16468319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0863 6720_PRDM10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.906271 lymphnode_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.13964 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7263-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Posterior parietal association areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44912 ATF7 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.25523 GSE255680_2_v_0_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle lumen COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE70935_2_v_4_cyfip1_human RummaGEO Gene Perturbation Signatures 1.0 null SENP7 Pathway Commons Protein-Protein Interactions 1.0 null PAX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1999 496100536_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.03755 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Ellagic acid_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209841 superficial stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77749 r9 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22364 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19657 GSE48812_9_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null EMX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5088 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K19699893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33636 ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135352_2_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null A549_Selisistat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153364 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null r11 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31097 NAT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09561 GTEX-OOBK-0008-SM-3NB27 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07732 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null OLA1 Pathway Commons Protein-Protein Interactions 1.0 null GSE145249_0_v_2_ppm1g_human RummaGEO Gene Perturbation Signatures -1.0 null OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24974 KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056412 CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null Temtamy preaxial brachydactyly syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.134 A549_ENMD-2076_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137392 GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null MDS - Myelodysplastic syndrome_Bone marrow stem cell_GSE4619 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.43103 maturation of ssu-rrna from tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna) GO Biological Process Annotations 2015 1.0 null GSK3A_knockdown_201_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.82368 BRD-K91387865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.94177 endometrium HPA Tissue Protein Expression Profiles -1.0 -1.22028 Ectorhinal area/Layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14086 intermediate stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36878 H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 NRF1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MOGGUVW CCLE Cell Line Gene Expression Profiles 1.0 1.56015 CTCF_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HE-22-JR80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265579 substantia nigra, reticular part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27379 CRCGN011_HEPG2_24H:A12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4485 GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211286_7_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE74251_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null RNASEL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48951 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K33438042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15048 ASXL1 ChEA Transcription Factor Targets 1.0 null H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7211-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null 4108_IMP4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.623262 GSE244730_0_v_1_erlotinib_human RummaGEO Drug Perturbation Signatures -1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rhombomere 10 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29969 Penis_Foreskin_Melanocyte_Primary_Cells_skin01 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.985858 GSE160373_8_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K12099407 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09703 SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE173307,GSE173391_0_v_1_rgcc_human RummaGEO Gene Perturbation Signatures 1.0 null SCC4 CCLE Cell Line Gene Expression Profiles -1.0 -2.01623 ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151689_0_v_1_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36367 BRD-K69074358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04079 organic cyclic compound binding GO Molecular Function Annotations 2015 1.0 null BRD-K19534880 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32831 anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34359 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03455 CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null HEC108 CCLE Cell Line Gene Expression Profiles -1.0 -1.97324 ATL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82626 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Major pathway of rRNA processing in the nucleolus and cytosol Reactome Pathways 2024 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7146-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912622 BHLHE22 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8097 hsa-miR-4429 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Chromosome 17q11.2 deletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.895 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE93309_2_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE147210_3_v_5_kmt2d_mouse RummaGEO Gene Perturbation Signatures -1.0 null decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19722 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02113 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymph node HPA Tissue Gene Expression Profiles 1.0 1.54308 GSE135030_3_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.76793 CTCF_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE215086_8_v_0_batf_human RummaGEO Gene Perturbation Signatures -1.0 null Nucleolar preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.956 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.860304 BRD-K56437119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42584 PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18 Rummagene Transcription Factor Associations 2026 1.0 null GCFC2 Pathway Commons Protein-Protein Interactions 1.0 null SNU119 CCLE Cell Line Gene Expression Profiles -1.0 -2.72964 H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GATA2-21186366-BM-HSCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null OUMS23 CCLE Cell Line Gene Expression Profiles 1.0 1.59437 BRD-K81001899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07795 A549_Tazemetostat_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0217859 BRD-K34804325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12678 GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927426 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16049 BRD-K43108627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11785 H3K79me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles 1.0 1.15078 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IP-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.117269 BRD-K92650579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10819 r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27723 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043209 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.66732 non-membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null GTEX-R3RS-0726-SM-3GIJR GTEx Tissue Sample Gene Expression Profiles 1.0 0.875143 BRD-K39449566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38477 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048237 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K82729862 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69576 GSE228181_2_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle GO Cellular Component Annotations 2015 1.0 null 2750_ETF1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.594852 sirolimus_mus musculus_gpl1261_gse21755 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rna metabolic process GO Biological Process Annotations 2015 1.0 null GSE138841_0_v_1_trim6_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null GSE123825_2_v_3_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRKDC Pathway Commons Protein-Protein Interactions 1.0 null SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5929 KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.895149 CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCN1 Pathway Commons Protein-Protein Interactions 1.0 null Bone structure disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.045 HCC1419 CCLE Cell Line Gene Expression Profiles -1.0 -2.30272 PELI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64135 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.63332 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.07804 liminal part of the r6 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29779 NSMCE4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2036 H3K9ac_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER ChEA Transcription Factor Targets 2022 1.0 null GTEX-WFON-0001-SM-3P61W GTEx Tissue Sample Gene Expression Profiles 1.0 1.49893 GSE196671_5_v_1_obox4_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIG-M5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.45108 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSE-0011-R6A-SM-3P5ZP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18505 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null preweaning lethality, complete penetrance IMPC Knockout Mouse Phenotypes 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Proglumide_NCI-H2030 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.015722 BRD-K71501826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09306 3537_GRINA_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.600949 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40677 r9 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90376 COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.939628 RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5993 NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.15859 SUGT1 Pathway Commons Protein-Protein Interactions 1.0 null MOLT-13 COSMIC Cell Line Gene Mutation Profiles 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.997148 CRCGN016_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.44826 BRD-K23713813 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32804 IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.908104 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.20558 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21124684 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10514 A549_Vandetanib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0135506 RAD21_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.856416 H3K4me1_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.347433 KP-3 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.00155 CRCGN015_HEPG2_48H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21569 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_ENMD-2076_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176562 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 7499_RPS11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.668432 PPAP2B Pathway Commons Protein-Protein Interactions 1.0 null Box H/ACA snoRNP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.691 MCF7_CYC116_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0106024 CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.46029 PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63896 K562_Entinostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164843 GSE242290_1_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null K562_RG108_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0187416 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.95344 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.93118 PPFIA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33609 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4701-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null colforsin-783 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Hereditary spastic paraplegia 7 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.016 Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_11_v_12_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K12345912 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40656 E2F1 ChEA Transcription Factor Targets 1.0 null GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24884 CEBPD_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE225218_9_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.068367 BRD-K11671824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00967 CALU Pathway Commons Protein-Protein Interactions 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05445 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2461 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.8996 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA ChEA Transcription Factor Targets 2022 1.0 null CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28587 SF126 COSMIC Cell Line Gene Mutation Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.969791 GSE206516,GSE206518_6_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null TSR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18053 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lymphnode_5a HPA Tissue Sample Gene Expression Profiles 1.0 2.76461 BRD-K56125296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5584 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null posteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13735 4152_INTS7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.556677 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17132 GSE202434,GSE202438_9_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null r7 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07945 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.01868 CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.00003 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10350897-j_biol-2022-0528-S1.pdf-181-USF2_USF2 Rummagene Transcription Factor Associations 2026 1.0 null mantle zone of r6Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29874 TC-71 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29095 GSE234637_3_v_0_ikzf1_human RummaGEO Gene Perturbation Signatures -1.0 null Dehydration_Hypothalamus_GSE3110 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.03837 GATA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8213 BRD-K42449328 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38579 SOX3-22085726-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_EVT-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05262 Intracellular non-membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PPARG ChEA Transcription Factor Targets 1.0 null HNF1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.1693 GTEX-OIZF-1526-SM-3MJGY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.847345 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.962351 CRCGN017_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.72836 GTEX-NPJ8-1726-SM-2YUNB GTEx Tissue Sample Gene Expression Profiles 1.0 0.875485 abnormality of circulating fibrinogen GWASdb SNP-Phenotype Associations 1.0 0.777194 9687_UTP6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -1.03132 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMN2 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN017_MCF10A.WT.HP_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0416 ERLIN2 Pathway Commons Protein-Protein Interactions 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_HNSCC_HNSCC_DDP_NOT_DDR_Genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null TRAF3IP3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RU72-0011-R2A-SM-2TF6O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824993 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null E2F4_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45156 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.55794 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5735_NOL6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.551573 MN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01056 Darolutamide_PANC-1 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00517426 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92604 NR1H2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.32 CHD1 ENCODE Transcription Factor Targets 1.0 null BRD-K51681402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53946 GTEX-POYW-0826-SM-2XCEM GTEx Tissue Sample Gene Expression Profiles 1.0 1.81825 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100453_HIP_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19787 GNPNAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13899 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-7974-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217873_1_v_2_nusap1_human RummaGEO Gene Perturbation Signatures 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.552287 CRCGN015_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.15925 GSE202434,GSE202438_6_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null MCF12A Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.857397 GSE116810_2_v_4_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null HINFP JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.9094 BRD-K41102088 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1769 YY1 ENCODE Transcription Factor Targets 1.0 null X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.992874 Noc4p-Nop14p complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.363 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.24091 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-8537-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K61259788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22528 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 6581_POT1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.588527 UTP-C complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.587 BCL3 ENCODE Transcription Factor Targets 1.0 null CRCGN008_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28835 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE218814_1_v_0_suv39h1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE168697_0_v_1_wdr6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE119498_0_v_10_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77149 BRD-K51017127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68447 CRCGN012_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5011 S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.370984 midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.887388 BRD-K68985225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90745 PMC11947124-41419_2025_7562_MOESM1_ESM.docx-40-ENSG00000128000_ZNF780B Rummagene Transcription Factor Associations 2026 1.0 null CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.15201 ZNF384_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE190186,GSE190188_8_v_10_apoe_mouse RummaGEO Gene Perturbation Signatures -1.0 null A549_Lenalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165697 DNAJA1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K82460510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48091 GSE140997_4_v_7_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_7528_KD_NOL9_SRP239128 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.9199 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE183251_4_v_6_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K68312794 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35143 BRD-K65969715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37265 AATF Hub Proteins Protein-Protein Interactions 1.0 null PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-Fig7e-CTCF_in_promoter_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventromedial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17412 BRD-K82224868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.15952 BARX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1487 mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32373 TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r8 part of the paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20633 BRD-K56242781 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26078 Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.183 PPP6R1 Pathway Commons Protein-Protein Interactions 1.0 null OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.0167 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039338 TCF12_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCDC66 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0092 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K68743686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59918 AOB, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3289 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KM-H2 GDSC Cell Line Gene Expression Profiles 1.0 1.7377 GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894151 GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.72039 GSE248883_0_v_1_shmt2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Prostate gland intraepithelial neoplasia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.789 CEBPB-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null 2747_ESYT1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.553952 GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171572_5_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.408 GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.837379 abnormality of blood and blood-forming tissues GWASdb SNP-Phenotype Associations 1.0 0.138261 LP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.939983 IAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07434 CA9-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null RAD21_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139016_3_v_2_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null PANC1 BioGPS Cell Line Gene Expression Profiles -1.0 -0.949742 CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles 1.0 2.11655 Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NQ-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TSE9-0226-SM-3DB84 GTEx Tissue Sample Gene Expression Profiles 1.0 0.891273 RAD21_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.9728 H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K84115096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19916 BRD-K66831269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34598 GSE183327,GSE183328_1_v_0_ddit3_human RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7155-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null hepatoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null RNF219 Pathway Commons Protein-Protein Interactions 1.0 null GSE185922_1_v_2_riok2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE215461_0_v_1_topotecan_human RummaGEO Drug Perturbation Signatures 1.0 null scale TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.299242 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.894668 GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.910302 FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147283_1_v_3_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF Rummagene Transcription Factor Associations 2026 1.0 null VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07104 retropontine reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12389 BRD-K29246335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09883 AC-18-DC84_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.35717 GTEX-QV31-0226-SM-447BO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965614 BRD-K42400613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4088 GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.893182 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.26932 GSE124920_1_v_2_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04379 EBF1 Pathway Commons Protein-Protein Interactions 1.0 null WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25894 AKIRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31639 H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12865_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.34184 HL60 BioGPS Cell Line Gene Expression Profiles 1.0 0.963002 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7492_RPP38_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.502631 PMC10746608-427_2023_709_MOESM5_ESM.xlsx-NR3C1_partners-NR3C1_known_protein_partners_according_to_BioGrid_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle part LOCATE Curated Protein Localization Annotations 1.0 null FLI1_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96239538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33329 BRD-K93998074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04688 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11711 SPI1 ChEA Transcription Factor Targets 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50462936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18934 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206516,GSE206518_1_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE199081_0_v_1_insr_mouse RummaGEO Gene Perturbation Signatures 1.0 null HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBNA1BP2 Pathway Commons Protein-Protein Interactions 1.0 null SK-N-AS GDSC Cell Line Gene Expression Profiles -1.0 -1.86517 BRD-K00789767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26817 Semicircular canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.674 ME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70805 BRD-K42966513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66815 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32458 PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null pre-primosome complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.736 superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68266 H3K79me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.861163 GSE140965_1_v_4_mybpc3_human RummaGEO Gene Perturbation Signatures -1.0 null JC-86-PD41_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211068 FCF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03469 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K17405621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54279 GSE140651,GSE140653_3_v_7_med1_human RummaGEO Gene Perturbation Signatures -1.0 null 7526_RPS4X_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.711044 RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6389 AIFM1 Pathway Commons Protein-Protein Interactions 1.0 null dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.90851 Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1-22096565-GC-B-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE205729,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K00676343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22094 hsa-miR-371b-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 GSE199644_3_v_2_palmitic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07473 H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 0.994318 GSE211128_7_v_6_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WFG8-0001-SM-4LVN8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.950217 PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K59709341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71279 Prostate cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 CCT3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K42650945 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30306 GSE186483_2_v_0_lrrk2_mouse RummaGEO Gene Perturbation Signatures 1.0 null FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Danusertib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0109315 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K83307202 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29101 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81S-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null posteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23667 AGPS Pathway Commons Protein-Protein Interactions 1.0 null BRD4_knockdown_223_GSE50865 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.28274 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.980323 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.915103 GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles 1.0 0.881456 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9366_TSR2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.546926 Primary somatosensory area, barrel field, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00356 SC-48849 (BRE) NURSA Protein Complexes 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7M4-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DNAJA3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K77627909 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46063 genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047745 GSE185519_3_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null mantle zone of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0867 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.38888 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RUSQ-1826-SM-2TF6E GTEx Tissue Sample Gene Expression Profiles 1.0 1.42164 GSE223893_1_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null VENTX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5882 Perturb_13411_KO_Sphk1/Sphk2_SRP403207 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.44855 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.78407 NUP153 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K67979704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63943 GSE219274,GSE219276_3_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_EED226_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.01524 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K84815485 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31658 COR-L88 GDSC Cell Line Gene Expression Profiles -1.0 -1.70613 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.991842 GSE220914_2_v_0_zdhhc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.64002 superficial stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90376 GSE185519_4_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_SK-N-SH_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K36176998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18689 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 macromolecular complex GO Cellular Component Annotations 2015 1.0 null vorinostat_homo sapiens_gpl10558_gse35242 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TAL1_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leukemia, Acute Megakaryocytic_Megakaryocyte_GSE2433 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.922 nizatidin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52696 DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.459718 GSE139348,GSE139349_1_v_0_dicer1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.05569 DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6389 GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28436 H4K20me1_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A_48H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.52956 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE114992,GSE114993_7_v_10_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fibrillar center COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.223 Primary somatosensory area, trunk Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15683 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reduced GeneRIF Biological Term Annotations 1.0 null ERCC5 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN010_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26183 ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.39645 PRDM14-20953172-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HUWE1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles 1.0 1.29215 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K75037209 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05478 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZU-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null salivarygland_6b HPA Tissue Sample Gene Expression Profiles -1.0 -0.995981 inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.921248 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.52628 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K57502201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66828 HCC1171 CCLE Cell Line Gene CNV Profiles 1.0 1.61653 CTCF_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GSE173232_1_v_3_sf3b1_human RummaGEO Gene Perturbation Signatures -1.0 null TMSB4Y CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88702 GSE202434,GSE202438_15_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U8-06A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K13564884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60107 BRD-K42480393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45482 BRD-K47584662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41681 NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04387 TAL1-20566737-PRIMARY FETAL LIVER ERYTHROID CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.6373 GSE135514_8_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18537 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 732_B4GALNT1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.525716 BRD-K76966915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3778 NELFA-20434984-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Transcription export complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.91 GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 2.01158 H3K4me1_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23148 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07658 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A5U2-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K93339508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4575 SRF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 936.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882977 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.874853 CRCGN016_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.2535 KPNYN CCLE Cell Line Gene Expression Profiles -1.0 -1.95288 10623_ZNF774_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.606071 CHD7 ENCODE Transcription Factor Targets 1.0 null ROS-50 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.27055 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.914597 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A465-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K90673570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15636 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04631 intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.870093 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SRF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null IKZF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RUNX2-24655370-MC3T3E1-MOUSE-BONE ChEA Transcription Factor Targets 2022 1.0 null oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39808 GSE163240_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null TAL1_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4769-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 NCIH508 CCLE Cell Line Gene CNV Profiles 1.0 1.40592 BRD-K78603273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00489 GSE102187_0_v_1_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A4QX-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null INKA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4362 ZIM3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6926 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A673 CCLE Cell Line Gene Expression Profiles -1.0 -1.52776 SNW1 Pathway Commons Protein-Protein Interactions 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.23501 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1Q0-01A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114013,GSE114014_1_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.581081 CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_SRT3025 HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162793 D341MED CCLE Cell Line Gene Expression Profiles 1.0 1.48886 GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null E2F1-17053090-MCF7-human ChEA Transcription Factor Binding Site Profiles 1.0 null 5462_NAPA_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.584801 SMAD4-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Neurofibromatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.122 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH520 CCLE Cell Line Gene Expression Profiles 1.0 2.23432 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3306-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_8_v_10_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GSE95302_1_v_4_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18003 pwp2p-containing subcomplex of 90s preribosome GO Cellular Component Annotations 2015 1.0 null BRD-K51363316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36548 CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleic acid binding GO Molecular Function Annotations 2015 1.0 null CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K59535072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86414 BRD-K31121304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49197 GSE118077_7_v_8_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5977-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ribonuclease MRP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.739 BRD-K93017276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88018 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null NCIH2291_LUNG CCLE Cell Line Proteomics 1.0 9.59899 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K85813125 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1464 GSE193258,GSE193259_2_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NOTO JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2375 PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.261 Retrosplenial area, dorsal part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18272 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null maturation of ssu-rrna GO Biological Process Annotations 2015 1.0 null GTEX-OIZH-2026-SM-3NB1M GTEx Tissue Sample Gene Expression Profiles 1.0 0.890626 Preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.889 BRD-K79995507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35932 CRCGN014_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07933 Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nucleus ambiguus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40286 outer CP in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.899677 intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE211931_2_v_3_ncoa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE162892_3_v_0_isox_human RummaGEO Drug Perturbation Signatures -1.0 null cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.843812 AML193 CCLE Cell Line Gene CNV Profiles -1.0 -1.79789 H3C11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29946 TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.735985 intracellular non-membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EK-01A-12R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CL-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04139 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPV-0008-SM-47JYW GTEx Tissue Sample Gene Expression Profiles 1.0 1.1632 4154_INTS9_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.530412 PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA Rummagene Transcription Factor Associations 2026 1.0 null MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null gamma-tubulin small complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.536 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A112-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of myeloid leukocytes GWASdb SNP-Phenotype Associations 1.0 0.214061 BRD-K16479784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36343 CTCF_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31999 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-6560-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE181513_0_v_1_usp7_human RummaGEO Gene Perturbation Signatures -1.0 null ZR7530 CCLE Cell Line Gene CNV Profiles -1.0 -1.35781 GSE145311_0_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null 17660535-TableS4b GeneSigDB Published Gene Signatures 1.0 null PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.868735 RAD21 ENCODE Transcription Factor Targets 1.0 null intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01162 GTEX-TSE9-0426-SM-3DB81 GTEx Tissue Sample Gene Expression Profiles 1.0 0.898662 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WHSC1 ENCODE Transcription Factor Targets 1.0 null BRD-K95578456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.11966 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F0-01A-12R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amidopyrine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.93045 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.67788 AD-06-OB47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21074 striatum_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.963173 PMC9810646-41598_2022_27273_MOESM1_ESM.docx-1-ZNF609_ZNF609 Rummagene Transcription Factor Associations 2026 1.0 null GSE89729_0_v_1_ppard_human RummaGEO Gene Perturbation Signatures -1.0 null membrane-enclosed lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.056848 GTEX-V1D1-1926-SM-4JBGX GTEx Tissue Sample Gene Expression Profiles 1.0 0.844173 BRD-K68223954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14998 9364_TSR1_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.511343 HDAC5 Pathway Commons Protein-Protein Interactions 1.0 null GSE135030_8_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null RAD21_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.677 A549_BMS-911543_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144961 90S preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.985 Retrosplenial area, ventral part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02704 MAPK8IP3 Pathway Commons Protein-Protein Interactions 1.0 null LOX IMVI BioGPS Cell Line Gene Expression Profiles 1.0 0.960941 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.23373 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35333 superficial stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01952 organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null U3 small nucleolar RNA-associated protein 6 InterPro Predicted Protein Domain Annotations 1.0 null orbital frontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59097 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03925 GSE166783_3_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.89797 PDCD11 Hub Proteins Protein-Protein Interactions 1.0 null 5-Fluorouracil_A498 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0219994 GSE202434,GSE202438_13_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73027631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00246 GSE48812_4_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE169691_1_v_2_saha_mouse RummaGEO Drug Perturbation Signatures -1.0 null DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.544816 A549_Pelitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168027 BRD-K47995281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75692 CRCGN016_MCF10A.TP53.M_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.57213 H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE194396,GSE194429_1_v_0_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null A549_JQ1_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0145976 CUX1 ENCODE Transcription Factor Targets 1.0 null GSE157383_6_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures -1.0 null 2473_EDARADD_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.620484 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25232 liver GTEx Tissue Gene Expression Profiles -1.0 -0.994831 6574_POP1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.646624 intermediate stratum of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03838 CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50816 HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.853579 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE198380_0_v_1_phgdh_mouse RummaGEO Gene Perturbation Signatures -1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YW-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2983-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skin HPA Tissue Protein Expression Profiles 1.0 0.789902 AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20493 CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.272793 MPP-89 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.06975 A549_WP1066_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0214618 KLF15_Deficiency_GDS2687_648_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Hip joint TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.393 RAD21_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE171486_4_v_0_ddx6_human RummaGEO Gene Perturbation Signatures -1.0 null PAX5 ENCODE Transcription Factor Targets 1.0 null KDM5B-21448134-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXM1 ENCODE Transcription Factor Targets 1.0 null 7493_RPP40_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.791622 PBX3 ENCODE Transcription Factor Targets 1.0 null X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.5692 BRD-K11573765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51376 Intracellular organelle lumen COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Maraviroc_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014535 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1761 nucleolus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.4676 Orbital area, medial part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42681 MONOMAC1 CCLE Cell Line Gene Expression Profiles 1.0 1.60473 BRD-K96733881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26863 Perturb_9811_KD_CNOT3_SRP117693 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.24628 inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.906618 dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.34597 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.39669 BRD-K77173942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54682 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4 Rummagene Transcription Factor Associations 2026 1.0 null GATA1_G1E-ER4_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_CVGBM-gene_name_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null SLC25A42 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K28375929 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09743 agranulocytosis GWASdb SNP-Disease Associations 1.0 0.884 RBM22 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K80109782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72005 RNF2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XGQ4-0526-SM-4AT6C GTEx Tissue Sample Gene Expression Profiles -1.0 -0.847608 GSE48812_8_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11880379-41467_2025_57480_MOESM3_ESM.xlsx-FOXP1_RIME_Limma-Gene_FOXP1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16966 REH Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.34899 CRCGN008_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.225 Nucleolus COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vidofludimus DeepCoverMOA Drug Mechanisms of Action -1.0 -1.06 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K97711917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26536 ELK4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7882 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_7_v_13_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.10156 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytosolic small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.642286 BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149903_6_v_1_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Retrosplenial area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53721 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KURAMOCHI CCLE Cell Line Gene Expression Profiles -1.0 -1.76275 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C2orf47 Pathway Commons Protein-Protein Interactions 1.0 null IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29335 IDI2 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MD-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16467 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DNAJB6 Pathway Commons Protein-Protein Interactions 1.0 null GSE202434,GSE202438_9_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null DNAJB11 Pathway Commons Protein-Protein Interactions 1.0 null GSE116810_2_v_3_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null microdeleted GeneRIF Biological Term Annotations 1.0 null hsa-let-7d-5p MiRTarBase microRNA Targets 1.0 null SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09566 vincristine_homo sapiens_gpl570_gse7556 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Accessory olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.24702 Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K71514806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.385 ZNF326 Pathway Commons Protein-Protein Interactions 1.0 null GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null heart_6b HPA Tissue Sample Gene Expression Profiles -1.0 -0.928128 MYC-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_Panc1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACIN1 Pathway Commons Protein-Protein Interactions 1.0 null A549_Navitoclax_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161073 HOXB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.0566 CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBM28 Pathway Commons Protein-Protein Interactions 1.0 null BRD-A68175400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25016 orbital frontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.984166 BRD-K19981693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02121 7423_RPAP2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.533293 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EO-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures -1.0 null A549_AT9283_10nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.013282 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HELZ2 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.17165 SUP-T1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.90758 GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48241 DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null TGBC11TKB COSMIC Cell Line Gene Mutation Profiles 1.0 null RAD21_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-0326-SM-33HCA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827729 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCT4 Pathway Commons Protein-Protein Interactions 1.0 null IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A86550573 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03386 POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null eed_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.436312 BRD-K56149020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05704 A549_Andarine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152482 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HF-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81Q-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tonsil_8e1 HPA Tissue Sample Gene Expression Profiles 1.0 0.886966 sno(s)RNA-containing ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.735 GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05718 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202284,GSE202289_7_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K55612106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41436 RITS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.964 CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.21412 K562_Filgotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187165 imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49701 CTCF-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.403 superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88202 STAT1 ENCODE Transcription Factor Targets 1.0 null PML Pathway Commons Protein-Protein Interactions 1.0 null BATF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6277 BRD-K05253426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17097 GTEX-OHPK-0326-SM-2HMJO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1775 GTEX-WYJK-0005-SM-3NMA1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52351 WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.295296 POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZEB1 ENCODE Transcription Factor Targets 1.0 null GATA1_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE183251_4_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.283 EPHB6 Pathway Commons Protein-Protein Interactions 1.0 null NCIH526 CCLE Cell Line Gene CNV Profiles 1.0 1.52581 CRCGN011_HEPG2_24H:H12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.154 POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Peripheral nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.281 BRD-K79318338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00403 DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.234124 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Iniparib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162311 GSE158834_0_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:A18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15164 CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1026 congenital heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.608885 RBBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23329 ANAPC15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08512 MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNG-M COSMIC Cell Line Gene Mutation Profiles 1.0 null layer 3 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4164 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.57708 RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174735_2_v_0_il22_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4343-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YAP1-20516196-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Watson syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21621 small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.537005 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03455 intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042065 CRCGN015_MCF10A.TP53.M_24H:D10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00035 GTEX-T5JC-0011-R2A-SM-32PLZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07452 PMC9666723__F8 PFOCR Pathway Figure Associations 2024 1.0 null MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2444 PEBP1_KO_GSE31150_52_mouse_pancreas GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Male reproductive system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07858 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114992,GSE114993_7_v_3_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3383-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K30921693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72896 COV413B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.842651 CRCGN009_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.79906 CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38558166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78737 JHOM2B CCLE Cell Line Gene Expression Profiles -1.0 -1.78663 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.288193 HCC1599 CCLE Cell Line Gene Expression Profiles 1.0 1.59202 GSE155031_5_v_0_dextran_human RummaGEO Drug Perturbation Signatures 1.0 null membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71995 non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null NUP58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39327 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29562 LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25345 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12293 HINFP JASPAR Predicted Transcription Factor Targets 1.0 null SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.849131 Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCL6 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K97445906 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41621 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null imatinib_homo sapiens_gpl96_gds3046 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.14114 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.53582 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Dysgraphia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.423 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.14114 nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null 8666_TAF5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.51296 Spinal nucleus of the trigeminal, oral part, middle dorsomedial part, ventral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17903 Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.39533 GSE120413,GSE120447_4_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PAXIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39394 posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.459 GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.956143 Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RO-01A-12R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BA-52-FW03_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220006 Hip TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.225 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 2.16298 FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346289 ITGA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20572 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.848064 snorna binding GO Molecular Function Annotations 2015 1.0 null GSK3A_knockdown_203_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.68119 GSE205163,GSE205164_9_v_4_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Tubastatin A HCl_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166095 spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.975641 BRD-K30298864 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35762 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17428 BRD-K03916755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4242 GSE121043_0_v_1_aldh1a1_human RummaGEO Gene Perturbation Signatures 1.0 null TBX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3408 GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32054 H3K9ac_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TMEM219 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23195 ChIP_CTCF_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ASXL1-24218140-BMDM-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null MYBL2 ENCODE Transcription Factor Targets 1.0 null GTEX-XBEW-0002-SM-4AT5O GTEx Tissue Sample Gene Expression Profiles 1.0 0.942643 Interstitial keratitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.534 ELP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18 GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20653 GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles 1.0 0.976353 GSE182680,GSE182683_7_v_12_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null BMI1 ChEA Transcription Factor Targets 1.0 null Primary visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07708 FOSL2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37949240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3173 17660535-TableS4c GeneSigDB Published Gene Signatures 1.0 null prostate gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.97455 spleen HPA Tissue Protein Expression Profiles -1.0 -2.14252 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59T-01A-21R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7527_RPS5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.706284 inner CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19075 Spinal nucleus of the trigeminal, oral part, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59726 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K17751525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15506 chromosome GO Cellular Component Annotations 2023 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51025 HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.981603 GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51865 AD-16-HL96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.312753 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81J-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30911 large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K07712233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17664 GSE245134_2_v_3_atg5_mouse RummaGEO Gene Perturbation Signatures 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7525_RPS3_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.521294 bromopride LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34452 superficial stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14759 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.29875 superficial stratum of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52638 Lateral ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88868 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7839_SF3B5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.519501 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.28533 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H69 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.33772 anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.999519 17533364-TableS2 GeneSigDB Published Gene Signatures 1.0 null GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.5704 BRD-A34774643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47789 BRD-K23923189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41894 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.278 posteroventral (inferior) parietal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.917165 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null 8645_TACC3_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.531418 IL13RA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10078 sirolimus-1080 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null small-subunit processome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 GSE167218_1_v_0_hoxd12_mouse RummaGEO Gene Perturbation Signatures -1.0 null HS 255.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07052 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04783 PMC8260656-41467_2021_24380_MOESM4_ESM.xlsx-ERG_EZH2-ENHANCED_ERG Rummagene Transcription Factor Associations 2026 1.0 null GSE158834_7_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null OCIAML5 CCLE Cell Line Gene Expression Profiles 1.0 1.53142 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the coagulation cascade GWASdb SNP-Phenotype Associations 1.0 0.254156 Temporal association areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41819 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38273665 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58613 GSE111247_2_v_7_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-HI-7169-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.05347 NCI-H2369 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.43025 GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.76325 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null DMS153 CCLE Cell Line Gene Expression Profiles -1.0 -1.71528 EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Galactose epimerase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.123 uterus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE163862_2_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25033 BRD-K45343543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36797 GTEX-WH7G-0002-SM-4LVN9 GTEx Tissue Sample Gene Expression Profiles 1.0 2.05966 MDN1 Pathway Commons Protein-Protein Interactions 1.0 null metergoline-5344 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K80176886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0042 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50916 CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZC3H11A ENCODE Transcription Factor Targets 1.0 null PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.888367 Lung squamous cell carcinoma_LUSC_TCGA-58-A46K-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100636_FWM_probable Alzheimer's disease_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.04331 OCUB-M COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE160817_5_v_1_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null K562_BMS-265246_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0201603 GSE161055,GSE161056_1_v_0_hira_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.26064 CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ1-0003-SM-3NMAE GTEx Tissue Sample Gene Expression Profiles 1.0 1.69542 Mpp10 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.65 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.262 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Organ system cancer DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.568 ZNF384_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU7-0426-SM-2XCDX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971974 lateral part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0867 Chromoplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.509 FOXP2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V955-0004-SM-3NMDH GTEx Tissue Sample Gene Expression Profiles 1.0 1.00352 BRD-K12513721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30199 mantle zone of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00435 TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5287 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052873 Fibrillar collagen trimer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.551 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Legius syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.203 BRD-K03461876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37709 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null zona incerta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.868374 FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null BRD-K72807299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21621 caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.54466 MYC_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FGF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0897 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SARS-CoV_96Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.62072 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZC-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PURB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15608 A549_Pracinostat_10nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0194851 GSE178227_1_v_0_tet1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K14470344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32171 organelle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.061246 GSE145249_1_v_3_ppm1g_human RummaGEO Gene Perturbation Signatures -1.0 null MRPL35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44198 TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null IK Pathway Commons Protein-Protein Interactions 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BN-01B-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03035 GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06478 BRD-K65108634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45566 YKG-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.3738 ALPHAK3 Kinase Library Serine Threonine Kinome Atlas 1.0 null A549_Filgotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149937 H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null outer CP in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3208 CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.5428 BRD-K58168959 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04459 SKNO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.44685 496100363_TCx_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.71574 nucleolar part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.00645 BRD-K55505527 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1739 nucleolus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829968 binding GO Molecular Function Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7693-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92254 BRD-K63008302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65067 Noc complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.94 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-30a-5p MiRTarBase microRNA Targets 1.0 null K562_Ofloxacin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016672 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KYSE-150 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.239 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me1_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.84206 GSE154350_1_v_0_ascl2_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null laterodorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23604 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.871198 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10715 Mesothelioma_MESO_TCGA-MQ-A4LM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RK-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE172146_2_v_0_mettl1_human RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lateral reticular nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55146 prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.864429 bromocriptine-2007 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null render GeneRIF Biological Term Annotations 1.0 null BRD-K69229416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55378 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Box H/ACA scaRNP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.39 KB-3-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.505 outer CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.878139 CAL-51 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.866 Intracellular anatomical structure COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 posteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21094 primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.828699 BRD-K07501194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02058 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19353 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02488 mantle zone of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10917 SF3B2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles 1.0 0.908093 THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.9176 GSE184479_3_v_2_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null abnormality of granulocytes GWASdb SNP-Phenotype Associations 1.0 0.315852 GSE129244_3_v_5_lmo2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE216757_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.871524 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null PU.1-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null layer 4 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15087 GSE169205_0_v_5_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3446 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4690-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12191 Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.4206 NCIH1385 CCLE Cell Line Gene Expression Profiles -1.0 -1.66515 GSE198165,GSE198166_7_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K24554824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35363 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE130956_0_v_3_icaritin_human RummaGEO Drug Perturbation Signatures -1.0 null IC-05-AW29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.274454 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE126777_0_v_1_otub1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_3H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.68486 BRD-K66573697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02981 BRD-K74626943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94364 inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.827684 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.65798 GSE57871_5_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null ribonucleoprotein complex biogenesis GO Biological Process Annotations 2025 1.0 null K2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.1066 GSE154337_0_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE162892_3_v_0_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ATOH7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5905 RET_knockout_270_GSE32093 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.11619 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K32906083 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89146 BRD-K16919185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00754 HDAC6 ENCODE Transcription Factor Targets 1.0 null BRD-K18562847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95958 SKBR3 CCLE Cell Line Gene CNV Profiles -1.0 -1.77061 GSE193588_1_v_0_pax3_mouse RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92815 NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.058 LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882977 YA-92-YO01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.467652 nuclear lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null THAP1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NFIC_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDCD11 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K26402831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40548 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ketorolac-7286 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE102486,GSE102490_1_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U8XE-0226-SM-4E3J3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14054 GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles 1.0 1.1978 GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles 1.0 1.26721 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.3553 H3K9ac_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r6 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1761 GSE89767_2_v_5_cebpa_mouse RummaGEO Gene Perturbation Signatures 1.0 null NEK9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19481 neutropenia GWASdb SNP-Disease Associations 1.0 0.884 DNAJA2 Pathway Commons Protein-Protein Interactions 1.0 null ATG2B Pathway Commons Protein-Protein Interactions 1.0 null T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.917882 GSE143994_0_v_1_ythdf1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_1_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN011_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6556 ribosome biogenesis GO Biological Process Annotations 2023 1.0 null Tooth germ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.062 NCIH1651 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 DNAJB2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC9 Pathway Commons Protein-Protein Interactions 1.0 null FGFBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84172 small-subunit processome GO Cellular Component Annotations 2015 1.0 null CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.43554 BRD-K69087429 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11485 GTEX-WCDI-0002-SM-3P61U GTEx Tissue Sample Gene Expression Profiles 1.0 1.03076 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.894418 GSE147613_1_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4538-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K71357636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15335 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.949249 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049954 ABI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70438 H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9417 Posterior parietal association areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62106 BRD-K13164804 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77203 H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882977 ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.27998 Caov-3 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.24532 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nr2e1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.3678 CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K96807219 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13251 RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265043 A549_2-Methoxyestradiol_10然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159952 NCIH2122_LUNG CCLE Cell Line Proteomics 1.0 2.12927 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QA-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31999 A549_GSK1070916_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0183274 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH841 CCLE Cell Line Gene CNV Profiles 1.0 1.37261 PMC11266089-Table3.XLSX-Fig1_Disease_targets-TP53_TP53 Rummagene Transcription Factor Associations 2026 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.989156 SUZ12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00435456 STAG1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K07274638 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19153 2102_DDX10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.513803 BRD-K37564297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08628 cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 1.9544 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEC50B CCLE Cell Line Gene CNV Profiles 1.0 1.41188 WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.35643 abnormality of the immune system GWASdb SNP-Phenotype Associations 1.0 0.114869 MLF2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K44245916 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05878 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4099-01A-02R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE231799_3_v_5_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null outer CP in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04757 Anauxetic dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.035 colon BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.869584 medial part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92815 BRD-K43692189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06534 GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles 1.0 4.15795 PMC11003700-pbio.3002240.s011.xlsx-MYCN-IMR32_RawData-Unnamed_2_MYCN Rummagene Transcription Factor Associations 2026 1.0 null NMS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.858 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.949524 alopecia, neurologic defects, and endocrinopathy syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.228 MVK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3483 KDM5B-21448134-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null FOXH1-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE182680,GSE182683_7_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.959453 Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195568_1_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleolar part GO Cellular Component Annotations 2015 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MYC_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.97714 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null nuclear part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.056466 BRD-K19652835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09866 small GeneRIF Biological Term Annotations 1.0 null GSE137818_5_v_6_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K26208451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87306 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Leber congenital amaurosis_Retina_GSE3249 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.56459 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01476 PMC8566473-41467_2021_26653_MOESM3_ESM.xlsx-SOX2_interacting_proteins-Gene_symbol_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81D-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null RXRA-24833708-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MA-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.80719 GTEX-POYW-0526-SM-2XCEY GTEx Tissue Sample Gene Expression Profiles 1.0 1.21545 BRD-K98961458 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1228 GSE242290_1_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null ncrna metabolic process GO Biological Process Annotations 2015 1.0 null SKMEL5 BioGPS Cell Line Gene Expression Profiles -1.0 -1.46655 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95792127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33604 A549_Mesna_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177883 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73D-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19261 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28057 BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.44878 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Lapatinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140185 Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.6534 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1975 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.82689 BE-79-QU25_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.275242 GSE261563_9_v_8_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null GSE160001,GSE160670_0_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures -1.0 null SKN Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.09729 GSE198254_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42051 BRD-K76437403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.26327 BRD-K11730256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01082 GSE182680,GSE182683_10_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.40533 GTEX-P44H-0011-R4A-SM-2XCEW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913338 Facial motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r4BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72819 BRD-K57786028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43295 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A7D0-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null superficial stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01194 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04269 ZNF443 Pathway Commons Protein-Protein Interactions 1.0 null GSE192513,GSE192515_1_v_0_atg16l1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 7507_RPS18_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.563914 superficial stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.3813 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 OB-06-WW76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252181 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null A549_Ivosidenib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016763 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38263 ETS1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11399095-44161_2024_532_MOESM14_ESM.xlsx-Sheet1-Supplementary_Table_13_DEG_in_the_AA_borderzone_in_AF_vs_SR_patients_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null abnormality of leukocytes GWASdb SNP-Phenotype Associations 1.0 0.192161 A549_Aurora A Inhibitor I_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0120083 GSE95077_5_v_0_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.43767 rRNA processing Reactome Pathways 2024 1.0 null SYNE2 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN009_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.38435 Leukemialymphoblastic(MOLT-4) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.950224 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K28764680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89793 r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15554 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A89Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null QB-88-PG52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.233047 H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K24719325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.05887 GSE118766_1_v_0_ifng_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A Pathway Commons Protein-Protein Interactions 1.0 null GLG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16778 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles 1.0 0.93866 Preribosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 GSE198165,GSE198166_0_v_2_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Pericentriolar material COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.136 DICER1 Pathway Commons Protein-Protein Interactions 1.0 null Brain ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mast cells BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.07512 BRD-K27653895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45653 Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.2789 CRCGN013_HEPG2_24H:H22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0235 VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.836491 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K29662535 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14668 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38972 GSE206729_4_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K68916730 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01755 GTEX-O5YT-0526-SM-32PK8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.9189 GSE234637_3_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles 1.0 0.923479 TPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34451 RRP12 Pathway Commons Protein-Protein Interactions 1.0 null 7525_RPS3_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.821275 CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.17937 CTCF_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5KZ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM222B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11704 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.053317 BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 Lung adenocarcinoma_LUAD_TCGA-55-1594-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE139120_1_v_0_urod_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 2.76769 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SJXC-0326-SM-2XCFI GTEx Tissue Sample Gene Expression Profiles 1.0 1.08763 9366_TSR2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.577186 FITM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63618 PMC7529806-41467_2020_18638_MOESM7_ESM.xlsx-Supplementary_Data_4-Supplementary_Data_4_TG_of_EPAS1_EPAS1 Rummagene Transcription Factor Associations 2026 1.0 null GSE158456_2_v_3_furin_mouse RummaGEO Drug Perturbation Signatures -1.0 null ATM_knockout_75_GSE23116 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.11057 BRD-K58382884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54062 GTEX-T5JC-0011-R5A-SM-32PLK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15787 GTEX-UJHI-0426-SM-3DB8Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03087 BRD-K85292767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50722 periventricular stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04167 HOS CCLE Cell Line Gene CNV Profiles -1.0 -1.67922 KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 H3K9ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE122215,GSE122217_0_v_2_peg10_mouse RummaGEO Gene Perturbation Signatures 1.0 null interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.953322 A549_Lomustine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160417 DCAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46946 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER ChEA Transcription Factor Targets 2022 1.0 null CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-320b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.830528 USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE197555_0_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null UTP18 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K77417197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36738 CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16207265 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50933 r9 portion of ambiguous motor nucleus (postmigratory) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73297 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08836 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04689 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RB1 Pathway Commons Protein-Protein Interactions 1.0 null SRRM2 Pathway Commons Protein-Protein Interactions 1.0 null vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.996858 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null POLR2B Pathway Commons Protein-Protein Interactions 1.0 null BRD-K91795767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65358 skin TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054311 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K78311779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64025 BRD-K06356885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37362 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.84615 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210101,GSE210114_8_v_9_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GSE213588_10_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.982032 2988_FBL_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.635309 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18128 SAGA-type complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.358 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 0.907857 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.581 K562_Resminostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152888 BC-56-BB82_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249016 SF-21 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.956 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Frontal pole, cerebral cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30577 POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44698 BRD-K21423050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56243 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3087 BRD-K08199068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.93365 GSE185519_6_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050715 Nodulus (X), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37441 A549_Thiotepa_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0204738 FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.427806 HS852T CCLE Cell Line Gene CNV Profiles -1.0 -1.42973 nuclear lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.200328 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DICER1_Deficiency_GDS3685_518_mouse_Hepatocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE207122_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K69466030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37594 MCCC2 Pathway Commons Protein-Protein Interactions 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2855-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04178 Sarcoma_SARC_TCGA-DX-A3M1-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null PMC11947124-41419_2025_7562_MOESM1_ESM.docx-40-ZNF780B_ZNF780B Rummagene Transcription Factor Associations 2026 1.0 null GATA1_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Malignant peripheral nerve sheath tumor DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.32 IRF3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7526_RPS4X_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.670434 HEK 293 T-rex BioGPS Cell Line Gene Expression Profiles 1.0 1.36928 hsa-miR-320c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 HCC1569 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.582 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MT1X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02517 SPSB1 Hub Proteins Protein-Protein Interactions 1.0 null Intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 3.742 RNF175 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70068 BNIPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43389 BRD-K58149231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0695 HCC38 CCLE Cell Line Gene CNV Profiles 1.0 1.48803 GSE135514_8_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE130437_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.863521 primary auditory cortex (core)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36687 FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE119498_2_v_4_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00041 FOSL2 ENCODE Transcription Factor Targets 1.0 null BA-84-WN26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.374383 GTEX-VUSG-1726-SM-4KKZL GTEx Tissue Sample Gene Expression Profiles 1.0 1.12427 GSE186471_1_v_2_carnosol_human RummaGEO Drug Perturbation Signatures 1.0 null