association	dataset	threshold value	standardized value
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.29645
superior occipital gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.916803
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11476
C6orf136	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29831
SIK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02479
ARFGEF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87184
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ARL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33912
HCC1599	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46844
ps96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
Acidocalcisome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
SPG21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05892
Prostate adenocarcinoma_PRAD_TCGA-G9-6499-11A-02R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02057
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.916312
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060957
ZBTB47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00008
POLG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4965
TOR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97292
CHK1_KD_GSE54267_671_human_U2OS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
TFAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32401
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NPAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45693
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.58001
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55642
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37484
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04111
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12834
RHOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04955
GPR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65059
GB-93-CC27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295401
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7862
EIF3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38894
CENPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09777
plant-type vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.639
POLR2A	ENCODE Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.916312
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07204
BD-49-MD69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325616
HMGB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.943
CASTOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17335
HCC2185	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.724731
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7334
Entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.369
icSARA deltaORF6_72Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.41688
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GIPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77349
Stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
NUDT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22924
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121441
ZNF626	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03619
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042903
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051981
csag2	GeneRIF Biological Term Annotations	1.0	null
GSE130437_2_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.60883
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
Iris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.401386
Lung squamous cell carcinoma_LUSC_TCGA-85-A4QQ-01A-41R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-42-WI29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304029
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5658
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.50124
HOXA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8362
LMNTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29219
Golgi cis cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.738
CRIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74451
Acidocalcisome lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.738
Midbrain central gray	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.771
NFATC2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62147
families	GeneRIF Biological Term Annotations	1.0	null
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0135
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7323
ZNF544	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98491
BIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42502
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.974193
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A2PC-01A-11R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Leaf tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.928
FADU	CCLE Cell Line Gene CNV Profiles	1.0	2.35101
CFAP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23171
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07204
TFAP2C	JASPAR Predicted Transcription Factor Targets	1.0	null
x-linked disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.953273
PINX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46738
diaphragm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.730208
ZNF474	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18217
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6192
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2096
proteasome storage granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.15364
SLC44A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43127
RDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59999
451LU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.985341
Agranular insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.327
murine	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2785-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3453
GTPBP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57506
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
CEPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12015
Endocytic patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
TMEM132A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84545
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hepatitis B	DisGeNET Gene-Disease Associations	1.0	null
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.857123
DFFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03951
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SNX12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86638
Malaria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
Mitochondrial proton-transporting ATP synthase, catalytic core	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.581
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04196
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070344
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NLGN4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90528
organelle assembly	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3869
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.977869
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06694
MUS81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13617
ECHDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60151
central nervous system development	GO Biological Process Annotations 2025	1.0	null
gamete generation	GO Biological Process Annotations 2015	1.0	null
Medial geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.99
769-P	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TOMM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82734
hsa-miR-181d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.983821
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.6694
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD2AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59837
Prostate adenocarcinoma_PRAD_TCGA-KK-A59Z-01A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059128
JUND	JASPAR Predicted Transcription Factor Targets	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.470836
496100666_HIP_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15298
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RO-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GLUL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22583
FANCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20042
NCOA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4769
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21176
C8orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77473
PHF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03024
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265021
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37235
TFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64463
PIGU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47659
RCM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49379
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7796
DTWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71355
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100517_TCx_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.47205
CC-18-YW57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246271
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.39473
MRE11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95178
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A5NE-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059388
icSARS CoV_24Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.60797
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.89214
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9677
IZ in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14139
MSH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25366
SF3A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00917
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70429
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.402901
NFILZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42071
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34484
ZNF264	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08064
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.89214
Brain Lower Grade Glioma_LGG_TCGA-WY-A85E-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RG-A7D4-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC2A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42512
LRRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89738
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF550	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26623
GTF3C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27904
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73707
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919451
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085824
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CT-01A-31R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.4918
AK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66725
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.40025
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.268
TSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27915
POLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8369
protein-DNA complex organization	GO Biological Process Annotations 2023	1.0	null
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58307
CAL851	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40142
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17175
chromatin organization	GO Biological Process Annotations 2023	1.0	null
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.834
PCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00989
KRI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15389
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.869001
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.830687
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46537
nonhomologous end joining complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.281453
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
non-small cell lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.092895
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1792	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
Microneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.52
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5318
FZD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28247
496100471_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61283
NEURL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3106
METTL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78578
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.80329
DXO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66661
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2577
H3-3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00118
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21048
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060778
multicellular organismal reproductive process	GO Biological Process Annotations 2015	1.0	null
ENTPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26604
SCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24321
PARP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39173
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.830638
MEC2	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
ZFTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4597
primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16776
CYLD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0096
dld-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.544152
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.853813
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05275
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5459-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heart valve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.331025
Vacuolar membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.669
Hyphal tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.73
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	3.40069
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5547
ADAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93869
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.946552
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.97687
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.35657
MPHOSPH9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23419
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51124
GTF2H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95795
chromatin binding	GO Molecular Function Annotations 2015	1.0	null
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.890045
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.962
entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.519253
HP1BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33954
TCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78903
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.95517
MIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3221
nucleolus	GO Cellular Component Annotations 2023	1.0	null
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.72047
CSNK2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12549
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.857123
SMIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00091
A253	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUV39H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76303
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
family	GeneRIF Biological Term Annotations	1.0	null
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09155
HOXD11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.326
B4GALT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60826
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-0.939434
SEC31B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40817
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16776
ZNF385C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41559
PVRIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50735
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.938305
PITX2_01_54	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.60382
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065739
NOL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52558
TRIAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53637
lateral geniculate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.681471
OVCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31842
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.27068
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34484
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15636
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
HIPK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31477
GBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92675
PMC3853418-1756-8935-6-34-S3.pdf-16-ZNF419_ZNF419	Rummagene Transcription Factor Associations 2026	1.0	null
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4545
CTSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69505
nucleus	GO Cellular Component Annotations 2023	1.0	null
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5581
496100411_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33507
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056857
ocular albinism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.07236
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
proton-transporting two-sector ATPase complex, catalytic domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.028
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876095
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.943662
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
subcuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.878011
SFSWAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43299
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Multiple synapse bouton, contacting multiple dendrites	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.575
aortic valve stenosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.529994
share	GeneRIF Biological Term Annotations	1.0	null
Central amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.680697
rectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076861
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236976
VPS36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14611
members	GeneRIF Biological Term Annotations	1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	93.72
ORC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31458
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077478
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17851
Adrenocortical carcinoma_ACC_TCGA-OR-A5K4-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02028
Mannan polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.808
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.52529
APOBEC3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89653
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-01A-12R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infection By Cryptococcus Neoformans	DisGeNET Gene-Disease Associations	1.0	null
PLOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43829
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8407
ZIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01984
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62337
Acute Myeloid Leukemia_LAML_TCGA-AB-2999-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HIPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77327
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMEM248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23288
HOXA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92764
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.883106
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
ZMYND11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36324
single-organism process	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8628-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.39174
ATF3_01_33	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.1138
BSPRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72608
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UNC13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74371
Optic lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.61
TCF4-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052592
ARHGAP45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42261
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.412391
19204204-SupplementaryTable1	GeneSigDB Published Gene Signatures	1.0	null
WIL2-NS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PEX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33031
GF-72-OO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216079
CALCOCO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46882
PMC3485261-pone.0046600.s008.docx-0-JAZAG_TGFB1__SIGNALING_VIA__SMAD4_UP_SMAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Acidocalcisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.512
MACC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15434
Membrane fusion priming complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ribonucleoprotein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
42-MG-BA	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	133.704
IBTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26866
ribosome assembly	GO Biological Process Annotations 2015	1.0	null
GALNT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80326
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828942
18172295-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.863637
GCIY	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34584
MAP3K21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64453
cuneus, left, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29541
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.842664
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
BCL11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15988
Infralimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.094
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
common	GeneRIF Biological Term Annotations	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4388
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10319
Medial vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.168
TMEM47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09878
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
proton-transporting ATP synthase, catalytic core	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.581
ST6GAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38403
Mitotic arrest phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
H2BC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07314
Pylorospasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	12.4866
TCF3	ENCODE Transcription Factor Targets	1.0	null
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.410491
Antipodal site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.096
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22086
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.50144
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61538
FREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45262
TACC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29384
testis	HPA Tissue Protein Expression Profiles	1.0	2.00057
Auditory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.812
SIDT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31507
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052406
TNNC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39648
Sarcoma_SARC_TCGA-DX-A8BH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30082
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inferior olivary complex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.98
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1113
EP300	ENCODE Transcription Factor Targets	1.0	null
TRPM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55749
nucleus	GO Cellular Component Annotations 2025	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.14118
KCNC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67102
CDK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56723
496100597_HIP_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18613
VANGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85765
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Protoxylem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6487
SMNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08058
Lung squamous cell carcinoma_LUSC_TCGA-77-8143-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-X4-A8KQ-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CALR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90694
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CHD2	ENCODE Transcription Factor Targets	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.871158
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
NAA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37955
Variably charged protein VCX/VCY1	InterPro Predicted Protein Domain Annotations	1.0	null
ZR751	CCLE Cell Line Gene CNV Profiles	1.0	1.51908
496100288_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.2609
NOBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10526
ZNF705D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65687
B3GAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12046
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840155
Acute Myeloid Leukemia_LAML_TCGA-AB-2898-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHA15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3581
FXYD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46596
ZNF287	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7194
Vacuolar lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.932
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.97643
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054935
ancestor	GeneRIF Biological Term Annotations	1.0	null
membraneless organelle assembly	GO Biological Process Annotations 2025	1.0	null
RPS21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55447
GSE148657_3_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
COL1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63852
PABPC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71883
GFPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44816
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49129
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05509
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.97882
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.5086
respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045466
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836066
intestinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065783
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSTZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22583
PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
AGPAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29832
ZNF594	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3464
IGFBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06757
ZNF708_01_130	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.93329
NCCRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98876
NNAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82962
rectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071371
DCUN1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16985
ANKLE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16199
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FBXO22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6793
HUH7	CCLE Cell Line Gene CNV Profiles	1.0	1.82048
Asi complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.299
QTRT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59371
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.935132
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21258
PPARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.72697
COA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34234
GABARAPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93431
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
GSE151612_0_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CLIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79511
BCP1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00395
GSE125219,GSE125221_5_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-37-IC77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204885
chromatin organization	GO Biological Process Annotations 2015	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07204
Placental Steroid Sulfatase Deficiency	DisGeNET Gene-Disease Associations	1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.872592
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08587
ZFAND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31598
intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MT-ND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11233
organelle	GO Cellular Component Annotations 2015	1.0	null
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44284
SRMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54682
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
TPRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42388
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.96033
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MRPL32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37707
pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.24996
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828942
ATPase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.939
RAD51C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.295
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876095
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.324239
Visual cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.345
OUMS23	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60695
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5914
CALCOCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39741
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.7257
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.949071
Lung adenocarcinoma_LUAD_TCGA-MP-A4TA-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.0885
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
ATR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83225
gastrointestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065783
TMCO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18341
Lung squamous cell carcinoma_LUSC_TCGA-56-6546-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spanx	GeneRIF Biological Term Annotations	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41969
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.8742
496100503_HIP_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.84937
PLA2G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13283
olfactory tubercle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.862844
nucleolus	GO Cellular Component Annotations 2015	1.0	null
MRPL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10517
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.920588
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6Y9-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAGOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85112
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.939299
MMAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23527
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.090926
organelle part	GO Cellular Component Annotations 2015	1.0	null
TLX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76489
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
icSARS CoV_72Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.23073
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9128
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16222
TOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.697
SLC5A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38869
NUDT16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57288
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.60444
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0221
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049201
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.07925
USP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27752
MUC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34575
ARG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7088
x chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.554318
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39959
x-linked ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.64576
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72219
thorax muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.674543
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37609
GSE160304,GSE163392_2_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.878801
PMC10079833-41467_2023_37542_MOESM11_ESM.xlsx-Sheet1-Supplementary_Data_10_Significantly_differentially_expressed_genes_identified_in_IGF2BP1-KD_cells_compared_to_control_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
EMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2273
MELK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56256
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.588
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061505
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
MICALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42224
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	12.6191
FAM118A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11852
macromolecular complex binding	GO Molecular Function Annotations 2015	1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
DCAF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75728
RTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81862
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0539
endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.082143
cholinergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.298165
AKT1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40853
Adrenocortical carcinoma_ACC_TCGA-OR-A5JK-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.902844
MAX_02_192	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61356
GMEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49397
Male infertility	WikiPathways Pathways 2024	1.0	null
PLEKHG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35389
RH-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SW1573	CCLE Cell Line Gene CNV Profiles	1.0	1.67039
UACC-893	COSMIC Cell Line Gene Mutation Profiles	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.88203
layer I of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.914461
together	GeneRIF Biological Term Annotations	1.0	null
colonic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.098441
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040348
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7J9-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.431
MTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98264
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.56538
HS683	COSMIC Cell Line Gene Mutation Profiles	1.0	null
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.390044
PAQR9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50302
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17076
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4332-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCNDBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42455
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.896886
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36802
CLN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27907
NOS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DHCR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31981
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0938
binding	GO Molecular Function Annotations 2015	1.0	null
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.897411
C9orf72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75534
Prelimbic cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.36
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.890992
sex chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.00251
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876095
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04586
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHST15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.03008
RGMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37002
urethra	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.447192
CTCF	ENCODE Transcription Factor Targets	1.0	null
Cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.117
ZNF468	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24236
male gamete generation	GO Biological Process Annotations 2015	1.0	null
NAGLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12198
seminiferous epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.537812
FAAP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30024
SRI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35342
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3442
PLAGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45673
cuneus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.61197
C18orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91657
NR2C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69322
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903436
LDAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07479
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833785
SGF29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30103
496100493_TCx_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.25571
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206445
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.168634
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21455
GSE153443_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.176485
HS578T	CCLE Cell Line Gene CNV Profiles	1.0	1.57692
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07315
PRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17076
PRXL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79012
SNU182	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32979
cytosolic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.112499
magnesium-dependent protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.654
PRR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04538
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBE2G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25893
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044196
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEPTIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69655
ATP6V0D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24692
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.635
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39264
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
BHLHE23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35739
YLPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75253
Anterior olfactory nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.566
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4651
ZNF384	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.6381
PRPF39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9343
Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
type iv pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.00399
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81E-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pallidohypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.5475
Thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.573
C11orf98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.32548
NCIH1618	CCLE Cell Line Gene CNV Profiles	1.0	1.4257
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3497
USP34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90361
P3H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40424
Fibre tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9542
CBY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93607
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.329361
TOR2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82032
cellular macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
SMIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67912
Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.446
colorectal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080752
hsa-miR-664	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
TLR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18674
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06057
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
OTULINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77083
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.957481
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7964
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.162109
Medial geniculate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.186
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Complete Atrioventricular Block	DisGeNET Gene-Disease Associations	1.0	null
DUXA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8373
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.976937
cellular component assembly	GO Biological Process Annotations 2015	1.0	null
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80999
PLAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93885
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51094
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.573828
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
UBE2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6906
EHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43988
POU3F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87011
Congenital vertical talus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
ATP6V1C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82507
POU3F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50465
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.77084
NFIX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76153
organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.924085
HDGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02554
SLTM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08757
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.77084
Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AADAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33298
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.949071
centromedian nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01411
CACUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30923
Occipital lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.227
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9323
brain development	GO Biological Process Annotations 2025	1.0	null
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73707
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Axon collateral	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.561
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17475
MROH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87035
Macrolide transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.519
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29269
SNU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
chromatin organization	GO Biological Process Annotations 2025	1.0	null
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
HPCAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01646
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B2-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMRTC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.10364
TAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1506
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0793
UFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32422
ARHGAP27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58979
HT144	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71689
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.62854
PUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8174
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07029
YWHAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77094
CD-07-GB34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218422
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0791
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05131
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-639	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
PMC3371315-NIHMS350140-supplement-8.xls-MCF7-T47D-SK-453_Down_MCF7-T47D-Supplementary_Table_1_ER-positive_FOXA1_signature_Genes_decreased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
bronchitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.466928
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF627	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26801
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ACVR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62299
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.983951
Haustorium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.528835
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
AMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23581
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863636
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.862005
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044589
chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.24424
DYRK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67181
HCC1143	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43611
ZNF746	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15254
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
LONP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35848
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0828
Hip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
PGPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6622
FDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98708
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.762
ep16	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
KLK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77323
colonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068666
AQP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68371
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02631
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7412
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0376
E2F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31911
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.932824
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
EBAG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73732
calcium:proton antiporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.8
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8156-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.842826
SAR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.113
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.450755
Growth cone membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.621
PAK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00565
Iris smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.75
CAVIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19318
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.349
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.3567
GSE80098,GSE80366_0_v_6_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MECP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54289
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16009
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279075
SLC5A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10898
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.282
external female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.536229
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51857
hsa-miR-181a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
YWHAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78938
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35438
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.741701
ZNF699	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45142
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A551-01A-21R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cardiovascular	GAD High Level Gene-Disease Associations	1.0	0.293278
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.873
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828942
FAM3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43225
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05343
NCI-H2030	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DGKK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92534
visual cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.33817
vcxy	GeneRIF Biological Term Annotations	1.0	null
SLC19A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94763
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
colorectal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088406
CCDC113	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50246
thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.143551
16081686-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
EP400	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73985
SRSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4571
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43153
OSC-19	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26852
GON7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74069
Face	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
LS1034	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54659
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876477
19377508-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
GSE206516,GSE206518_1_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21707
Lung squamous cell carcinoma_LUSC_TCGA-60-2721-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67249
nucleus	GO Cellular Component Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3921	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
SLC26A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15699
Bacterial Infection_Leukocyte - Monocyte - Macrophage (MMHCC)_GSE6435	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.47881
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.840218
IGR1	CCLE Cell Line Gene CNV Profiles	1.0	1.45126
CCER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37313
S0-EE-YC7H_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266425
DCAF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02689
ZNF561	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99818
Globus pallidus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.999
AMFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93165
ribosome biogenesis	GO Biological Process Annotations 2023	1.0	null
HOXD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.12742
SNU738	CCLE Cell Line Gene CNV Profiles	1.0	2.21746
ventral lateral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.978307
TROAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08497
DPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68674
CITED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64327
TEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40646
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.14886
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.659
ARL14EP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81153
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8626
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.920757
MIS18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22488
BA-92-CZ75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244375
organelle organization	GO Biological Process Annotations 2015	1.0	null
DD-77-GV27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.42855
ENAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37059
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.257358
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1604
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38046
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.857123
antigens	GeneRIF Biological Term Annotations	1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.916458
nuclear lumen	GO Cellular Component Annotations 2025	1.0	null
NCIH2052	CCLE Cell Line Gene CNV Profiles	1.0	1.97289
Bacteroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
POMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43479
lingual gyrus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.02298
EPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86855
TIRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6991
secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.177154
CJM	CCLE Cell Line Gene CNV Profiles	1.0	1.62508
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6623
PIK3R4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99065
RSU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67663
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.260184
IFI16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71496
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.950647
ZIC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73269
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.976332
Ktp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV1_01_161	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.32224
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22392
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.30303
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kallmann syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37809
ATXN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1637
y chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.916243
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32178
HELZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34404
MRPL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46812
BARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6925
PHF20L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40485
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11809
Basal forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.265
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00259
CCDC9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95649
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.832
proton-transporting ATP synthase complex, catalytic core F(1)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.304
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062791
GPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84227
HCC1171	CCLE Cell Line Gene CNV Profiles	1.0	2.09601
TTC39C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65964
PEX14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0835
CCDC184	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38374
ZNF318	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63888
FOXA1_OE_GDS4957_144_human_LNCaP prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NDUFB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80207
MRPL35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88123
CNPPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52577
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35597
mantle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.416576
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4166
ZNF513	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59128
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11859
GSE245270_2_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
L-363	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.69
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2631
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOWAHD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3286
aortic valve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.457864
LEO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40604
ZSCAN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75402
a72	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.836
JAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02177
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16009
Lung squamous cell carcinoma_LUSC_TCGA-98-8021-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.215534
Ichthyosis	DisGeNET Gene-Disease Associations	1.0	null
QB-35-FO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293153
RPS29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11552
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53316
Mesophyll cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08492
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.938342
colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079074
PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.519
Polarisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.59
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.941444
SNU-C5	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6166
ANKRD46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52542
MIGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23778
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.76043
ge86	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.708
CBLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18505
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q5-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11396_KD_YAP1_SRP333272	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.1602
COX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33278
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839572
MUSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62247
BF-94-CQ58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338771
ribosome assembly	GO Biological Process Annotations 2023	1.0	null
DCP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88693
Prostate adenocarcinoma_PRAD_TCGA-Y6-A8TL-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28306
A3-KAW	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.987672
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039893
EXOSC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25352
obstructive lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.099252
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.8476
CAPN15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25308
CPSF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39563
Nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NCIH2228	CCLE Cell Line Gene CNV Profiles	1.0	1.42639
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.255567
Striate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.586
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1708
OD-03-CA36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372883
ZBTB8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61313
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.681106
CLK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92089
NDUFAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32608
ARL5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04181
PMC3029394-pone.0016617.s001.xls-Up-regulated-Table_S1_Genes_up-regulated_by_SOX2_over-expression_2_0-fold_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Calcineurin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.878
GSE148010,GSE148120_3_v_2_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4819-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7666
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9553
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0581
A375	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
DB-41-OE47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202839
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48957
mp88	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
SPI1	ENCODE Transcription Factor Targets	1.0	null
Tongue muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.264
Actin cortical patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.799
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5109
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6763
TEAD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60716
Symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.524
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
nucleolus	GO Cellular Component Annotations 2025	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
NCIH2030	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67735
GPANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34049
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.181994
INTS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97501
BTBD18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71501
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.530381
Acute Myeloid Leukemia_LAML_TCGA-AB-2838-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057008
C17orf107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3346
Lung squamous cell carcinoma_LUSC_TCGA-43-2576-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mental Impairment	DisGeNET Gene-Disease Associations	1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4952
HYOU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76707
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23675
PSMB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07909
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06694
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03426
CD248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90024
PPM1K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10884
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223177
GSE193258,GSE193259_2_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040389
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.888092
NCI-H1355	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0747
ASCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43215
EA-22-SB72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20088
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2969
Systemic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vacuolar transporter chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.279
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.347408
Hypertrophic pyloric stenosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
Symplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.774
496100467_FWM_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1918
USP6NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22513
HSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27201
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57458
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054011
Sarcoma_SARC_TCGA-DX-A7EU-01A-22R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4206
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.270214
MYOZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.59066
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ARL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25909
cell part	GO Cellular Component Annotations 2015	1.0	null
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.182
ADRA2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41358
FOXH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04543
Acute Myeloid Leukemia_LAML_TCGA-AB-3001-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.532
Mental Retardation	DisGeNET Gene-Disease Associations	1.0	null
BE-34-JO19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244336
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
lateral geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.727741
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.2437
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4A-Supplemental_Table_S4A_Differentially_expressed_genes_upon_ZFX_Knock_down_in_C42B_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
CPNE7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11471
RERFGC1B	CCLE Cell Line Gene CNV Profiles	1.0	1.43123
BD-90-DK64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.440642
SLC39A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18174
CHRDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24296
SLC7A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38527
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.292257
GSE131649_2_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6773
layer II of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60597
PPIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05138
LU-134-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.301039
bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.124588
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32613
MVK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62731
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.954592
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6996
DROSHA_02_145	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60006
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
FYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25731
POLH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22551
inferior occipital gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16897
PHLPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8616
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
TP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37498
LS411N	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36614
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7413-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATXN7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36515
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3431
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5092-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CELF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08673
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7468
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
HES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12083
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.574017
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2927
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
ACT-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.178
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264442
DONSON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37215
Meiotic prophase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A7FA-01A-21R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
seminiferous tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.171973
CH25H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24383
CALHM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10763
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.56927
cellular component organization	GO Biological Process Annotations 2015	1.0	null
GSE48812_2_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pontine nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.313
single organism reproductive process	GO Biological Process Annotations 2015	1.0	null
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2064
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92253
STON2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89636
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.985341
reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.210589
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.54
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.983951
nucleolus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.160053
BIRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80653
GTF2E2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58853
RAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50784
Xylem parenchyma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.766
TCEANC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31603
CAL33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64101
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7926-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SATB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22269
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
vacuole-mitochondrion membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.236
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
nuclear part	GO Cellular Component Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T8-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049272
TTLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.03314
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212755
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.749
colorectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07989
NUDT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73439
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296416
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
OV56	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836066
PSMC3IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04533
496100351_FWM_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.42702
THUMPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60769
ZNF639	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01076
S0-EE-XKW4_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329343
Brain Lower Grade Glioma_LGG_TCGA-DB-5275-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DHRS4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3019
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.87163
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.983951
ISL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50055
GSE130396_7_v_6_braf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919451
GSE130396_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRK-NU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.058638
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YW-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Claustrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.977
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40594
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9598
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-B_FUS-DDIT3-eGFP_vs_WT-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.077324
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.87369
MFAP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82568
BT474	CCLE Cell Line Gene CNV Profiles	1.0	1.73227
POGLUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80085
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BEN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80972
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0722
nuclear lumen	GO Cellular Component Annotations 2023	1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70267
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
UF-28-DW05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293744
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0789
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21258
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21893
Anaplastic thyroid cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.136
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05248
RAF1_activemutant_219_GSE42964	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.51737
HOXC10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8313
lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.077801
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06424
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.291898
MMACHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41184
ZNF813	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42297
CFAP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3485
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043232
COR-L311	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
C2orf49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88734
SIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56181
NMU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32621
cypt	GeneRIF Biological Term Annotations	1.0	null
IQGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55359
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5B-Up_H3K4me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3781
Arbuscule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.883
Pulvinar	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.046
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RERFLCSQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.5081
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
colonic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069011
SREK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66371
Pancreatic adenocarcinoma_PAAD_TCGA-XN-A8T3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZDHHC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1127
Developmental Delay (Disorder)	DisGeNET Gene-Phenotype Associations	1.0	null
Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHOS4	CCLE Cell Line Gene CNV Profiles	1.0	2.59999
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LAMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12232
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PCDHB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08163
SNU-61	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Extrastriate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.472
SALL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82052
ABI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82867
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
metabolic	GAD High Level Gene-Disease Associations	1.0	0.293278
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3912
Acute Myeloid Leukemia_LAML_TCGA-AB-2836-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81688
Lung squamous cell carcinoma_LUSC_TCGA-21-1082-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nucleolus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.841674
MDAMB361	CCLE Cell Line Gene CNV Profiles	1.0	1.57593
carbamoyl-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.762
orbital frontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.997696
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2134
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5355
SRSF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1475
ACBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00683
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.949071
Regio oralis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.098
R3HDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68173
MRFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89133
NEXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19775
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.984805
EIF4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32931
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.988333
RPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3174
PRR12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31636
Food vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.531
REP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56892
U5 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.778
NR2F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6048
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.428993
IKZF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09307
Kinetoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.707
spermatid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.285671
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.862402
spermatogenesis	GO Biological Process Annotations 2015	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919451
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3921
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25989
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59218
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.930962
HS-74 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.844
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-50	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053062
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22627
EID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90637
PMC7462863-41467_2020_18186_MOESM13_ESM.xlsx-Suppl_Data_11-Supplementary_Data_11_Driver_genes_NOT_found_in_the_Mongolian_cohort_compared_with_previous_HCC_studies_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.93605
PARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58461
HNRNPA1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23944
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.094026
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.01496
Postcentral gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.81
CACTIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78128
GABRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41772
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
16707423-Table1	GeneSigDB Published Gene Signatures	1.0	null
TFCP2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29494
HCC-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
reproductive process	GO Biological Process Annotations 2015	1.0	null
Non-Obstructive Azoospermia	DisGeNET Gene-Disease Associations	1.0	null
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
dna repair complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.080609
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.468162
SPIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85661
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ribosome biogenesis	GO Biological Process Annotations 2025	1.0	null
CD83	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29409
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31475
NT5C3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95497
PMC12659123-12864_2025_12285_MOESM12_ESM.xlsx-Table_S12-Table_S12_Differentially_expressed_genes_after_SPI1_knockdown_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
LCLC-103H	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
SPEGNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08787
ZNF48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73525
JMJD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27113
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
aortic valve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.444499
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ZNF449	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87376
MXRA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75597
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828942
TBL1XR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46647
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
H1-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72244
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283061
LE-94-HL75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21798
PMC11116544-41698_2024_606_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_4_Significantly_differentially_expressed_genes_between_TCGA-HNSC_patients_carrying_amplified_MYC_and_wild-type_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36245
Anterior commissure	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.089
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DLG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44426
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37345
GRIK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38697
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3259
Laterodorsal thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.97
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044683
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11859
H2AC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29913
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00574
Somatosensory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.833
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.870882
NCI-H1048	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lateral geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.728
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041309
ELP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96832
ESRRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.41459
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.877451
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9936
Spinal trigeminal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.326
lingual gyrus, left, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.886504
Raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.8038
Meningoencephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11859
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3695
WDR46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42635
ZNF564	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43322
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.928946
central nervous system development	GO Biological Process Annotations 2023	1.0	null
prostate	GTEx Tissue Gene Expression Profiles	1.0	0.966907
EID3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94878
Cell pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.438
pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.328708
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03765
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
Oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
DHX38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31003
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46802
outer SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.849399
GSE163275_1_v_0_irf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
647V	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43213
HMGCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34028
Lateral geniculate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.714
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41719
autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.325552
Purkinje layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.043
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.05482
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043986
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0325
Lung squamous cell carcinoma_LUSC_TCGA-22-5481-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FYTTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66816
hsa-miR-181c	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
MOSMO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86251
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06946
BEN	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
CMTM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26568
lateral posterior nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.865526
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CL-40	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Intrinsic component of Golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.697
WRNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02755
PRKACG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56549
WDR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99665
TDRD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96176
MED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45973
PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-A_FUS-DDIT3_vs_both_controls-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.829633
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.877451
19204204-SupplementaryTable5	GeneSigDB Published Gene Signatures	1.0	null
Perturb_15416_KD_KDM3B_SRP187702	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.21099
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0864
HSPA14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92467
female pudendum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.543756
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.985341
STAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16191
ZNF391	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25487
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CPNE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50773
METTL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3989
TOE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52757
GLS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8739
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289452
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IPC-298	COSMIC Cell Line Gene Mutation Profiles	1.0	null
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.863509
TRIM23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36486
SOX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4362
small intestine	GTEx Tissue Gene Expression Profiles	-1.0	-0.835417
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_state_immune_markers-AP2_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
MEC1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070595
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAD50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16394
GSE110802_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Paw	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.167
TFAP2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.258
fusiform gyrus, right, bank of cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.846369
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.09536
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27404
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042964
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10686
FOXA1_OE_GDS4957_10_human_LNCaP prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZNF701	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29516
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.07925
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.955721
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.886877
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Endolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.532
SPIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3688
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XF-42-ES96_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202311
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35281
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3534
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9497
Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4838
Medial septum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
WDR89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19429
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_state_markers-AP2_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
HOXA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87221
OLIG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3748
DPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04718
GF-46-LK68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.632356
PMC3189923-pone.0025991.s001.xlsx-CENPT-Unnamed_1_CENPT	Rummagene Transcription Factor Associations 2026	1.0	null
PPIL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63774
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2062
SBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35946
STAT1_02_23	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62578
EIF4ENIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77114
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085868
Nuclear inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.046
Integral component of Golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.704
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
18172295-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
Outer dynein arm docking complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.607
hsa-miR-4653-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
X-linked ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.483
VCPIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92985
DPYSL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4994
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.18954
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29118
posterior group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16144
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06694
Ammonium transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.557
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MN-01A-22R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57806
MANSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00812
ZNF75A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87774
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74771
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.50688
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053854
CA-73-BW50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.700475
GCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06079
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7661-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055257
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
NCI-H838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-8022-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28295
SLC22A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.83465
GLIS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72783
CTNNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84713
Mental Handicap	DisGeNET Gene-Disease Associations	1.0	null
PMC11589140-41416_2024_2881_MOESM1_ESM.pdf-219-ZNF285_ZNF285	Rummagene Transcription Factor Associations 2026	1.0	null
RIPOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11223
Vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040347
UBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09696
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.880741
SCAMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05362
NDUFB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78095
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33413
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
CTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46896
SLC25A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12559
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49939
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.859688
KBTBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94541
WA-06-QR58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370307
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36035
LAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.685
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2444
USO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08927
Ookinete	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.93
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YR-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.925595
posteroventral (inferior) parietal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16776
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Epicotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054634
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.904152
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NRARP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65155
SMARCA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98444
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01548
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.962568
FADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62706
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01614
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANKRD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61263
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	1.76844
MOB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92489
MLLT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91003
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.91711
H3C10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10448
KP-1N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AF-73-ON54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216621
DE-24-AX80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229382
CB-10-YX20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244192
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064032
COPS7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43988
GSE193258,GSE193259_5_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-450b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
TMEM126A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85326
GRPEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93872
RNF170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.71153
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7749
NDUFV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52893
VIPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18466
RTKN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87846
NCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11211
LSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40564
BHLHA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53005
SLC22A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74698
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A84U-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DDIT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85491
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
URI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10488
CCDC66	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03966
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1292
DGKZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98087
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061032
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9775
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.866676
MTRF1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.515
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.348148
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.912983
NCCSTCK140	CCLE Cell Line Gene CNV Profiles	1.0	1.37735
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.289226
TLNRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28686
LBH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77006
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075017
CEP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43455
SCN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1155
SOCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13741
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7395
IGFBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01027
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.05779
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458123
Sarcoma_SARC_TCGA-X6-A8C6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cytosolic proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.938795
GSE214931_1_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37325
Abnormal Mental State	DisGeNET Gene-Phenotype Associations	1.0	null
CTSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13223
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
HNRNPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41982
SKES1	CCLE Cell Line Gene CNV Profiles	1.0	1.87124
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Iris sphincter muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.885
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3119
PTF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55654
ZNF71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03206
A375	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86461
496100408_PCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.48586
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260267
lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050625
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50324
UQCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.401
RTN4IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88166
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101986
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9851
primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.167812
MYNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14695
WT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2081
DHRS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30504
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07204
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16372
CMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07435
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8746
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39387
NHLH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48031
A-CA-04-2009(H1N1)_0Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.83116
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241845
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11055
H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Retrosplenial region	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.087
kallmann syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.09209
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21258
H3K27me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4262	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
F12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67726
DDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77711
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM243	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69898
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Motor cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.607
CNPY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44477
OE33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nuclear part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y6-01A-21R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05858
SNU719	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57548
VWDE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81369
PAX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75487
Apoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.007
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
KBTBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67722
RETSAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97062
Cell tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.542
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.822
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.655
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06318
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CAL-33	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
ATPSCKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8857
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
MFF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99543
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23593
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3686
EE-83-WF69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276845
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6185
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38197
Prostate adenocarcinoma_PRAD_TCGA-EJ-7785-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81229
TMEM177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75547
CPOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01972
G2E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35286
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043452
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
HEPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55673
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.838
PMC10630337-41467_2023_41954_MOESM5_ESM.xlsx-diffGenes_Mutant_vs_cont_48_h-2_down_regulated_genes_IRF4-C99R_versus_control_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
MTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57696
Lung squamous cell carcinoma_LUSC_TCGA-85-A5B5-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS6ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08423
PLIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0881
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EMSY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07575
autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.300173
GSE80098,GSE80366_0_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.711587
496100387_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29867
HUH-1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
RFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19114
SWAP70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35813
SPATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99387
CERS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33738
aorta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090085
PMC3189923-pone.0025991.s001.xlsx-CENPB-Unnamed_1_CENPB	Rummagene Transcription Factor Associations 2026	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.441
SRPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43257
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19922
PDE7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91809
CKS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74187
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03307
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.883451
LKAAEAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52222
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.672897
TAOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65264
GABPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09374
MSL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51117
ZNF773	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29087
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
Caudate putamen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.16
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7835
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EmrE multidrug transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.585
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0598
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863636
PRDX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4375
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25759
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.51375
Head capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
A3KAW	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
planum polare, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04811
LHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50468
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839572
TTLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27319
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2127
mifepristone_homo sapiens_gpl6947_gse39654	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Chondrodysplasia punctata	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.541
RHEBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35035
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1877
TMEFF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5636
PMC4011582-oncotarget-05-1052-s002.docx-3-Upregulated_in_CTCFL_BORIS_High_1_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
Subiculum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051041
TCAIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38056
lingual gyrus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33527
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061332
MANEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62891
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FKBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46059
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HI-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HH-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99226
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05601
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.69687
WE-43-PZ45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344258
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1553
PAX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86071
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11219
RNASE8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52407
PLEKHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61111
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8869
Medial amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.304
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16009
inferior occipital gyrus, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04338
Hak	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.126
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8088
CLIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67258
CWC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14796
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.92242
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
non-membrane-bounded organelle assembly	GO Biological Process Annotations 2023	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839572
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51859
basal forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.278251
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GY-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC39A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89271
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052435
ZNF263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6273
RGMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10718
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061126
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19427
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.901703
CYBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64775
h4s	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.396465
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87508
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCNMB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53731
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.831903
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92201
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
plant-type vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.703
SISO	COSMIC Cell Line Gene CNV Profiles	1.0	2.15058
KHM1B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.929
PDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56251
Nucleolus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88855
Guard cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.954
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PRKACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33848
HUH1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7609
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.07127
NCI-H2227	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2188
PMC9314667-Table_1.xlsx-Regulons-SOX10_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4977-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.476
GSE149096_2_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29495
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67143
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.857323
Golgi lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.027
TUBB2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.281
MSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70042
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.93809
HCC2157	CCLE Cell Line Gene CNV Profiles	1.0	1.32903
Hypogonadotropic hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264546
proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.168143
TE-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24863
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086783
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7415
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00638
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.866173
C1orf198	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82549
Cryptococcosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P1-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4132
Parietal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.701
SC5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44441
ZNF578	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29749
ERCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60649
PEG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46346
MAGED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83445
hsa-miR-181b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.975268
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50338
SNUC5	CCLE Cell Line Gene CNV Profiles	-1.0	-2.1285
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29358
Lung squamous cell carcinoma_LUSC_TCGA-43-A475-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
DPP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.322
HOMEZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11931
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3971
ANKS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9295
RNF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60827
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844884
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3367-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4A-Down_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045551
AR_01_192	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.65404
MATN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42276
body wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.163348
TUBA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40287
OUMS27	CCLE Cell Line Gene CNV Profiles	1.0	1.37407
ARIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17187
EB-09-LQ45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308784
CSTF2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05404
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4121
DPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03948
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
striate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.801459
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919451
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1364
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT-144	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BW-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.948541
nerve	GTEx Tissue Gene Expression Profiles	1.0	1.12531
SAP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87156
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1239
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.45556
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876095
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.830525
ANKEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35823
intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Fungal infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	1.0	7.2108
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28295
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054972
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A6MB-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RASSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48746
Opportunistic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
ZNF367	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55612
NDUFV3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85668
Germ tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.552
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0147
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49942
ZNF266	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70568
Perturb_11405_KD_RB1_SRP099582	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.6432
rectal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076194
NCI-SNU-1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
H3118	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Down syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
NDUFS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27036
nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.857123
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
brain development	GO Biological Process Annotations 2023	1.0	null
GIT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20674
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
ribosome assembly	GO Biological Process Annotations 2025	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
RPL36A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96495
Tegmentum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.174
PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
A172	CCLE Cell Line Gene CNV Profiles	1.0	1.64505
NACC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7458
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.88251
HOXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05563
PDPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70734
ANKRD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.57371
PDAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08254
SLC22A23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67142
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058145
SWSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87919
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.923083
PMC4271336-13041_2014_88_MOESM6_ESM.xlsx-Genes_in_GENE_CARD_MR_or_ID-Gene_Cards_MR_and_ID_genes_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828942
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051961
FAM110A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89135
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03491
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TRPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21657
CX-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.281
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.060472
MFM-223	COSMIC Cell Line Gene CNV Profiles	1.0	2.15058
HSFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17109
ribonucleoprotein complex assembly	GO Biological Process Annotations 2015	1.0	null
NCI-H3122	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.85607
Piriform area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.233
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.85386
TRIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14173
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Palisade parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
Cerebral peduncle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.93872
SEC24D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74631
ZNF384_02_27	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.6074
SNU1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.15802
colonic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070524
RCH-ACV	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ETV1_01_179	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.69672
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11234
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.336876
GSE188721_3_v_1_mesp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058048
YMB1	CCLE Cell Line Gene CNV Profiles	1.0	1.41114
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.602088
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11257629-media-9.xls-METTL3_KD_upregulated_Genes-METTL3KD_UPregulated_Genes_1694_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.79091
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_5_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
RPL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01366
JRK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72508
Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SSX2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97577
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94605
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
C12orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4751
Dorsal raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.077
CLSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41164
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.970506
hsa-miR-2861	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
SH2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55
NCIH196	CCLE Cell Line Gene CNV Profiles	1.0	1.96648
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GALR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51903
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.957019
ATP5MC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56087
CDS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48937
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46508
postcentral gyrus, left, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10443
PCDHB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56283
Lung squamous cell carcinoma_LUSC_TCGA-56-8307-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6610_KD_FXR1_SRP113319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.5258
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09951
occipital lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.2296
MD-09-FE75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201011
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.17275
TRAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50551
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02487
lingual gyrus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70883
Congenital disorder of glycosylation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
PDE5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07916
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DAAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87991
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_1_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8082-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GRHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2013
B3GNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7156
Pons	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.254
PAXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23347
USP49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24793
CORVET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.661
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.55262
Habenula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.076
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07206
ILF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76655
MBLAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11172
SENP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06297
ADAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61852
ZNF587B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46631
ATMIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79261
CCDC120	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76423
RPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23608
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040192