association	dataset	threshold value	standardized value
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
NB5	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.85881
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sigmoid_Colon	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.853821
Perturb_3806_KO_Ptpn2_ERP124267	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.59231
XAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62171
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05752
KLF4-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Protein phosphatase 4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.518
COLO783	CCLE Cell Line Gene Expression Profiles	1.0	1.42968
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987402
SC-1751 (TIA1)	NURSA Protein Complexes	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.206082
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20606
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BL457 (TCERG1)	NURSA Protein Complexes	1.0	null
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975285
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_13205_KO_Hdac3_ERP123505	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.65711
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
receptors	GeneRIF Biological Term Annotations	1.0	null
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30791
LN215	Achilles Cell Line Gene Essentiality Profiles	1.0	1.02223
hsa-miR-450b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
GSE97278,GSE97280_2_v_1_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14596_OE_UQCRC1_SRP177975	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.24967
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.8787
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3390_KO_Utx_SRP242086	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.86808
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27655
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10829
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia	ClinVar Gene-Phenotype Associations 2025	1.0	null
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.07048
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44896
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
proteolysis	GO Biological Process Annotations 2015	1.0	null
G70994MS	GlyGen Glycosylated Proteins	1.0	null
ATP2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79294
SMARCA4-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218299
ELF1	ENCODE Transcription Factor Targets	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.31358
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88999
hsa-miR-4252	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42236
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86292
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.548565
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZKSCAN1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201401_2_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.86774
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CG-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_POU5F1_16518401	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Prostate gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899725
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391931
FOS	ENCODE Transcription Factor Targets	1.0	null
K562_ENMD-2076 L-Tartaric acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123729
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.32022
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6871_PSMD3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05022
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66722
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39996
epidermal cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147240_3_v_4_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65739
MAX	ENCODE Transcription Factor Targets	1.0	null
KIF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21384
GSE206784_2_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07308
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934582
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
vascular disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
H4K20me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3313-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU869	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66694
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39561
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43394
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14787
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.46641
Perturb_7314_KO|KD_UPF3A_ERP130416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.44031
periventricular stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09326
escrt i complex	GO Cellular Component Annotations 2015	1.0	null
PMC11079265-Datasheet3.xlsx-Single_MI-Genes_share_between_two_or_more_target_genes_in_the_network_analysis_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210101,GSE210114_0_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34932
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.81525
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36906
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07999
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-548ae	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CHD1	ENCODE Transcription Factor Targets	1.0	null
ZDHHC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1043
RMGI	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.04681
hsa-miR-3074-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
K562_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189317
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
multivesicular body assembly	GO Biological Process Annotations 2023	1.0	null
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07848
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.17538
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
intermediate stratum of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22111
interspecies interaction between organisms	GO Biological Process Annotations 2015	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Congenital Pectus Carinatum	DisGeNET Gene-Disease Associations	1.0	null
A4 noradrenergic cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59048
salivarygland_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.46243
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Membrane fusion priming complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.581
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02167
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atg1/ULK1 kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.151
K562_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180625
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEx SmallIntestine 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	5.11508
OVSAHO_OVARY	CCLE Cell Line Proteomics	1.0	2.28618
A253	COSMIC Cell Line Gene CNV Profiles	1.0	2.15402
Endocytosis	KEGG Pathways 2026	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03097
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158228
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PROSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26648
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6874_PSMD6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.82837
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hereditary spastic paraplegia 73	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941258
496100406_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08424
ISTMES1	CCLE Cell Line Gene Expression Profiles	1.0	1.34749
MVB12A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE221327_1_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3470785-NIHMS377161-supplement-3.pdf-320-HBP1_HBP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15555_KO_SLFN11_SRP327912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.57777
A549_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015975
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45639
NR3C1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
protein targeting to vacuole	GO Biological Process Annotations 2025	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7468_KD_ELL2_SRP136956	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.93652
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46031
EP300	ENCODE Transcription Factor Targets	1.0	null
HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.434
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13575
hsa-miR-454	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Creutzfeldt-Jakob disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
COQ8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6592
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
LP-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.74438
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80518
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48639
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12766
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-549	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81452
Perturb_14184_KO_KDM1A_SRP289469	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
UST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21812
Perturb_18396_KO_Gpnmb_SRP298610	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.78164
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04606
hsa-miR-3161	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
endosomal transport	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-A4VP-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954946
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00052
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.051887
dorsal part of CoP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11654
SMARCA4	ChEA Transcription Factor Targets	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lysosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.304
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8430-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H211	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.56077
cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A5OB-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARS-CoV MA15_Day7-PFU-10^4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.02329
bj	HPA Cell Line Gene Expression Profiles	1.0	1.8294
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.875841
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.94537
GSE48812_0_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
r8 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33427
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.03538
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.1725
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08233
ACCMESO1	CCLE Cell Line Gene Expression Profiles	1.0	1.36577
MYO1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02337
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14185_KD_KDM1A_SRP289469	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PLCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18281
PPIA	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12347849-mmc1.pdf-22-ENSG00000178764_ZHX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210885_2_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Defactinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
SNU245	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49221
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.82101
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.075325
Spinal muscular atrophy with lower extremity predominant	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
PSMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01988
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73941
multi-organism intracellular transport	GO Biological Process Annotations 2015	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891743
hsa-miR-4799-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
ESCRT III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.62
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30967
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DBF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01567
hsa-miR-130b	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
SOX4	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.894089
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2204
disease	GWASdb SNP-Disease Associations	1.0	0.02582
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978528
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	2.00983
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.04645
organelle part	GO Cellular Component Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4670-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6793-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spastic Paraplegia	DisGeNET Gene-Disease Associations	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66317
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KYSE-50	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.19365
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r8Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18696
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4303	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98835
LNZ308	Achilles Cell Line Gene Essentiality Profiles	1.0	1.22426
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.63068
superficial stratum of r2BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19225
melanocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Hereditary spastic paraplegia 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.009
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27269
ZBTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07732
Oligodendroglioma_CNS - Brain (MMHCC)_GSE2223	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.60878
GSE131161_2_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.85487
abnormality of movement	HPO Gene-Disease Associations	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7910-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE185872_0_v_1_methotrexate_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T5JW-0126-SM-4DM6K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955016
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57297
PMC9742974-mmc2.xlsx-Differentially_expr_transcripts-BEN_GTF2IRD1	Rummagene Transcription Factor Associations 2026	1.0	null
lung	HPA Tissue Protein Expression Profiles	-1.0	-1.29395
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMYD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11316
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.86947
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.930092
corticoid layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40044
E2F4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
icSARS-Cov_Day2_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.10013
RPL13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23157
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFATC1	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
lateral part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83037
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68042
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24D-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hereditary spastic paraplegia 26	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.595
Hereditary spastic paraplegia 45	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
H2AZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15184
hsa-miR-34a	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-130a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44598
Perturb_7248_KO_LEF1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.76791
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
abnormality of the cerebral vasculature	GWASdb SNP-Phenotype Associations	1.0	0.311139
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.990695
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17428
PMC4090166-pone.0102079.s006.docx-0-SAFB2_SAFB2	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.56268
Hereditary spastic paraplegia 77	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
QGP1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.24196
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264268
mantle zone of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29576
hsa-miR-130a	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEIS1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CETUXIMAB	DGIdb Drug Targets 2026	1.0	2.94067
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX3	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-5R-AA1D-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6969-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.868085
cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.4
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAL1	MotifMap Predicted Transcription Factor Targets	1.0	null
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.5021
hsa-miR-4277	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Nucleus ambiguus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02151
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE188774_1_v_0_hkdc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_270_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.925906
Perturb_13271_KO_Msl2_SRP192624	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.46127
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stroke	GWASdb SNP-Phenotype Associations	1.0	1.00059
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8
hsa-miR-4528	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.835727
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endosome membrane	GO Cellular Component Annotations 2023	1.0	null
Hereditary sensory neuropathy type 2C	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
Perturb_745_KD_LIMK1_SRP262340	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.74518
TCF4	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X261-0626-SM-3NMD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870873
ODAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36948
Lung squamous cell carcinoma_LUSC_TCGA-22-5482-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052306
hsa-miR-152	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MB-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50541
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.058101
PMC4739739__F3	PFOCR Pathway Figure Associations 2023	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CNOT3-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11385326-joces-137-261952-TableS5.xlsx-AP2_possible_interactors-Gene_names_AP2_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9623_KO_CALR_SRP333390	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35363
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATF3_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1813_KO_N4bp1_SRP255180	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.51327
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-18a-5p	MiRTarBase microRNA Targets	1.0	null
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.595707
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33821
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_9135_KD_TP53/PKM2_SRP079926	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.72425
Lung adenocarcinoma_LUAD_TCGA-86-7701-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular protein transport	GO Biological Process Annotations 2025	1.0	null
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.691374
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57976
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_9_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CREB1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180371
late endosome membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-RWS6-0926-SM-47JXE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880065
cell lysate	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286026
intermediate stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29397
MKN7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5331
K562_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156584
KM12	Achilles Cell Line Gene Essentiality Profiles	1.0	1.37911
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30819
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220286
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23441
HCC70	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131467
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.891106
A549_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152033
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r8 part of lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11955
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48113
retina	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07813
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBM22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0123
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20944
WDR5-24793694-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
SKCO1_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.73708
K562_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153268
NCIH1581_LUNG	CCLE Cell Line Proteomics	1.0	2.09698
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.925106
ATG2-ATG18 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.414
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-1326-SM-4AD4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01437
GTEX-WFON-0626-SM-4LVLX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8754
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07686
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.951951
Tendon sheath	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176394
Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.78174
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7997-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.04624
SIRT6	ENCODE Transcription Factor Targets	1.0	null
UBA52	Pathway Commons Protein-Protein Interactions	1.0	null
Microtubule bundle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.565
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.839664
Perturb_14149_KO_KBTBD4_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
sirolimus_mus musculus_gpl1261_gse21755	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.01827
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063018
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
tendon sheath	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CNOT3	ChEA Transcription Factor Targets	1.0	null
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1147
CAOV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12108
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A4JJ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
kidney	HPA Tissue Protein Expression Profiles	1.0	2.38337
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02078
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.847397
hsa-miR-138	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
Microcephaly	DisGeNET Gene-Disease Associations	1.0	null
DEPDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1143
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SRF_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.21181
organelle	GO Cellular Component Annotations 2015	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10735
3557_GSTCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.683077
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.877094
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
osteoblasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.922917
RAB3A_KO_GDS2483_701_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-N-AS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.708
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8842
hsa-miR-4762-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
SP2_02_42	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59007
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
intracellular protein transport	GO Biological Process Annotations 2023	1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14146
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28656
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109619
Rectum adenocarcinoma_READ_TCGA-G5-6572-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00312
Gait Disturbance, Ctcae	DisGeNET Gene-Phenotype Associations	1.0	null
Assembly Of The HIV Virion	Reactome Pathways 2014	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.40265
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0793
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13244
CEBPB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883152
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
spleen	GTEx Tissue Gene Expression Profiles	-1.0	-0.894958
GTEX-QXCU-0126-SM-2TC5Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887672
TBP	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8191-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Synovium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE248858_6_v_2_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262141
hsa-miR-548f	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
TSG101	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
19841744-TableS5	GeneSigDB Published Gene Signatures	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27864
Viral Infection Pathways	Reactome Pathways 2024	1.0	null
RB1_KD_GSE50532_659_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310662
sorting	GeneRIF Biological Term Annotations	1.0	null
CEBPB_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950075
GSE186316_0_v_1_ccn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937986
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38173
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	3.15607
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.905488
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE98705_1_v_0_mdm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139769
H3K27ac_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
global developmental delay	HPO Gene-Disease Associations	1.0	null
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218495
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5226
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
UTY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56309
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_7_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067913
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1381
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286807
mortality/aging	GWASdb SNP-Phenotype Associations	1.0	0.413807
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2781
dorsal part of JcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22266
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.986949
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
Perturb_15099_KD_SREBF2_SRP385600	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.58103
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	1.0	1.78289
LAMTOR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08577
TCF3-18467660-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922455
ventral subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06539
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65117
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949603
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25226
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90529
Omegasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.363
PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBR7_KD_significant-Unnamed_23_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40385
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984155
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27613
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.883972
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r3 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29751
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127727
mantle zone of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26068
4349_PRORP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50512
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15578
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Meis2	MotifMap Predicted Transcription Factor Targets	1.0	null
9857_WEE1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04667
PATU8988S	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45908
endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.30121
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18255
MVB12B	Pathway Commons Protein-Protein Interactions	1.0	null
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58436
MYC_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GPRASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13627
CBLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10502
tonometry	GAD Gene-Disease Associations	1.0	null
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49784
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235036
K562_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017706
CDC45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51677
hair disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.468441
ESCRT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.77
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE145915_0_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.4193
paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
16166195-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-AA_UP_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
ATF3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-0426-SM-48U29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9346
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36686
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200866
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.894762
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37727
A549_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158126
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902724
GSE146982_3_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organic substance transport	GO Biological Process Annotations 2015	1.0	null
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.69143
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.85313
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08613
Perturb_9693_KO_GPNMB_SRP382180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8529
ZNG1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42331
hsa-miR-940	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE179031_3_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE125211_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	1.24828
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
medial superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71047
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-500b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229178
THAP1	ENCODE Transcription Factor Targets	1.0	null
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.716895
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.822814
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8307
Prostate adenocarcinoma_PRAD_TCGA-EJ-5516-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JV-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.836125
REST_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33425
NEDD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19907
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48113
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
X-linked spondyloepiphyseal dysplasia tarda	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.907853
SBC5_LUNG	CCLE Cell Line Proteomics	1.0	5.96786
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66111
Atg12-Atg5-Atg16 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.983
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938496
BL438 (NCOA3)	NURSA Protein Complexes	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
NKX2-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01556
PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-Unnamed_1_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
C1orf35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33945
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.73086
cerebrovascular disease	GWASdb SNP-Disease Associations	1.0	0.343758
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14564_KO_Ubap2l_SRP296872	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.26287
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lysosomal lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.853
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03154
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5887-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15729
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15755
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
virion assembly	GO Biological Process Annotations 2015	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24437
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.80931
MRPL54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25198
organelle assembly	GO Biological Process Annotations 2023	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824645
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6857_PSMC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15897
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239025
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01626
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6919
GTEX-WFG7-0426-SM-4LMK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926241
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K36me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.829209
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05087
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7502_KD_PHF12_SRP194754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.89084
GSE190235_3_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PPP1R3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22764
GSE193258,GSE193259_2_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30014
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31156
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06524
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MATH1	MotifMap Predicted Transcription Factor Targets	1.0	null
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-2.07216
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.60636
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22174
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31318
hsa-miR-186	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68421
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hereditary spastic paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06295
ATPase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.829
CALU-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.986
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950915
K562_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154464
spastic paraplegia 53, autosomal recessive	OMIM Gene-Disease Associations	1.0	null
3948_HSD17B10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.617146
HCC1833	CCLE Cell Line Gene Expression Profiles	1.0	2.58173
H3K36me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527022
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cellular anatomical entity	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.4
A253	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3657	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
JHH4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.32972
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5971-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.70512
Failure To Thrive	DisGeNET Gene-Disease Associations	1.0	null
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	GO Biological Process Annotations 2015	1.0	null
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18504
organelle assembly	GO Biological Process Annotations 2025	1.0	null
Cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.613
ESCRT-0 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.462
Endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.334
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31964
ISTMES2	CCLE Cell Line Gene CNV Profiles	1.0	2.143
496100597_HIP_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.62088
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.5671
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17653_KD_DNMT3A_SRP367237	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.05291
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41754
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16143
Perturb_9767_KO_Cdk1_SRP287303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.11523
Prostate adenocarcinoma_PRAD_TCGA-EJ-7125-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19573
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of brain morphology	GWASdb SNP-Phenotype Associations	1.0	0.177316
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80237
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931698
Perturb_10328_KO_Dnmt1_SRP132702	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.69135
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55828
SIN3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-49-EJ23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288007
hsa-miR-4723-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Kidney Chromophobe_KICH_TCGA-KL-8325-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.281776
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Troyer syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3141
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27249
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.70059
Prostate adenocarcinoma_PRAD_TCGA-VN-A88Q-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869088
ALPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17869
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.69872
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169155_3_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7515907__F3	PFOCR Pathway Figure Associations 2024	1.0	null
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SRD5A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33777
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.92608
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
invasion	GeneRIF Biological Term Annotations	1.0	null
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.877365
SP1	ENCODE Transcription Factor Targets	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
RRP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30445
hsa-miR-548aj	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.20334
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.20848
ESCRT complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29536
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.88614
GTEx Breast 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	3.30815
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884305
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.72414
SRF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06893
hsa-miR-298	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
TCF3	ChEA Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7693-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845932
Lysosomal HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.841
H3C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28879
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
STAT1	ENCODE Transcription Factor Targets	1.0	null
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838669
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
2796_EXOSC9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.91606
GC-74-QF56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237795
GTEX-W5WG-1726-SM-4LMI5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903283
Perturb_195_KD_Slpi_SRP056340	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.5946
BACH1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.941005
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3910540-725780.f1.xlsx-Table_S5-MYC_target_genes_in_human_ES_cells_Ji_Wu_et_al_2011_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10689
hsa-miR-4736	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5978-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17277_KO_Kdm1a_SRP185978	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.86492
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42484
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3407-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08317
GSE232631_5_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3007-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.907689
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34457
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1704
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0987
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6776
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61857
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.869648
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
intermediate stratum of DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4128
HEC59_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.8072
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52468
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195	Rummagene Transcription Factor Associations 2026	1.0	null
macroautophagy	GO Biological Process Annotations 2025	1.0	null
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.11843
FOXM1	ENCODE Transcription Factor Targets	1.0	null
single-organism intracellular transport	GO Biological Process Annotations 2015	1.0	null
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15972
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.66674
GTEX-QDVJ-1226-SM-48U1V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11786
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26899
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10915192-ab-23-0304-Supplementary-Table-S6.pdf-13-SOX6_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31318
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_233_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.95134
EFM19	CCLE Cell Line Gene Expression Profiles	-1.0	-1.98935
Disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE151090_5_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8615-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05305
GLI3T_Lipofectamine transfection_GDS4346_616_human_Panc-1 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
viral protein processing	GO Biological Process Annotations 2015	1.0	null
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00921
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31142
GATA3	ENCODE Transcription Factor Targets	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10718
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7048-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902674
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNMC-1326-SM-2XCFK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2189
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07464
NFIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.281
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1383
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976921
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCC2814	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45484
hsa-miR-548c-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.80641
BL8110 (RAD54L2)	NURSA Protein Complexes	1.0	null
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48598
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42938
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.16872
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19653
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227255
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150777
PIAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04076
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.60462
nuclear part	GO Cellular Component Annotations 2015	1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
EM2	CCLE Cell Line Gene Expression Profiles	1.0	1.55282
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r8 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22708
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04066
Late Phase of HIV Life Cycle	Reactome Pathways 2024	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_6_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.154
Nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88495
r4 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28877
abnormal embryo size	MGI Mouse Phenotype Associations 2023	1.0	null
CNPY4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24803
ATM_Deficiency_GDS1544_769_mouse_Lymph nodes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TYKNU_OVARY	CCLE Cell Line Proteomics	1.0	2.8072
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01967
HIV Life Cycle	Reactome Pathways 2024	1.0	null
TBC1D24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55832
Brain Lower Grade Glioma_LGG_TCGA-DU-7306-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-27a	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
autosomal	GeneRIF Biological Term Annotations	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.891461
muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JHOS4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78223
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.997458
decreased body length	IMPC Knockout Mouse Phenotypes	1.0	null
PMC10245467-mmc3.pdf-259-ZNF701_ZNF701	Rummagene Transcription Factor Associations 2026	1.0	null
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4777-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
bone	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.975435
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44892
ZNF143	ENCODE Transcription Factor Targets	1.0	null
Endoplasmic reticulum-Golgi intermediate compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.856
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09099
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.14718
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.30079
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24507
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96652
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824703
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.139877
viral life cycle	GO Biological Process Annotations 2015	1.0	null
Hypoxia_Astrocyte_GSE4483	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.67856
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5313
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95923
Phagophore assembly site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.337
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32705
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1157
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.162763
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.110462
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
late endosome to vacuole transport via multivesicular body sorting pathway	GO Biological Process Annotations 2023	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.2608
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152441,GSE152442_1_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880024
MYOD1	ENCODE Transcription Factor Targets	1.0	null
endosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 5A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.626
GATA2_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26217
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.865721
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
TE15	Achilles Cell Line Gene Essentiality Profiles	1.0	1.08403
MXI1	ENCODE Transcription Factor Targets	1.0	null
Hereditary spastic paraplegia 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
RNF213	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44425
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81D-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.9166
AP-5 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.615
intermediate stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09164
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW1116	CCLE Cell Line Gene Expression Profiles	-1.0	-2.64021
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4503	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88722
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.47348
Mesothelioma_MESO_TCGA-LK-A4O2-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE215314_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438955
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02607
EFO21	Achilles Cell Line Gene Essentiality Profiles	-1.0	-3.31016
PDAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07832
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G-292-Clone-A141B1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.31235
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14867
Phagophore assembly site membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03416
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDST8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.908316
Anaplasmosis_Leukemic Cell_GSE2600	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.42196
POLR2AphosphoS2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r8Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10771
Perturb_4989_KO_Ythdc1_SRP212677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.15795
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UNC13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53512
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_OE_GDS3444_576_mouse_Cultured embryonic stem (ES) cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE186483_1_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3513
Perturb_4367_KO_Peg10_SRP167954	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.52267
outer CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17771
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19343
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Assembly Of The HIV Virion	Reactome Pathways 2024	1.0	null
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913416
Delayed Speech And Language Development	DisGeNET Gene-Phenotype Associations	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308091
TAL1	ENCODE Transcription Factor Targets	1.0	null
RELA	ENCODE Transcription Factor Targets	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.617202
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1725
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.112
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X261-1026-SM-3NMDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01257
Perturb_98_KD_INTS8_SRP262320	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.55641
GRX cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.839
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229505
Erlotinib_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0123021
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67637
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.884213
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.24401
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.945397
Perturb_2272_KO_Mettl3_SRP110576	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.65737
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31744
GATA2-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04851
FOXA1_01_105	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59248
PPARG	ChEA Transcription Factor Targets	1.0	null
MYB	ENCODE Transcription Factor Targets	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23562
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RI-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.83542
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.90635
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03609
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186216
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09385
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39415
establishment of protein localization	GO Biological Process Annotations 2015	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.894083
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Seedpod	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
placenta	HPA Tissue Gene Expression Profiles	1.0	1.32969
Endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Lobule II, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00687
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
ERA-27197147-CHIP-SEQ-ENDOMETRIOID-ADENOCARCINOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07782
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516997
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988421
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31578
PRPF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55648
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853362
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16765
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.50349
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B	ChEA Transcription Factor Targets	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.59332
HCC366	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46172
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36616
TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_10705_OE_ATF5/PROX1/CYP3A4_SRP287297	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.9885
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68D-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
skin_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.35051
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.71339
NRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-dORF6_96Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.71342
mantle zone of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54394
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
Perturb_13208_KO_Foxd3_SRP060372	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.78755
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0643
WASH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.875
Perturb_11702_KD_MIR31HG_SRP051359	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.6198
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.828543
cellular process	GO Biological Process Annotations 2015	1.0	null
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00113
HS 675.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.856941
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.06404
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
trastuzumab_homo sapiens_gpl570_gse15043	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.984403
r10 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25891
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.980725
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7388_KO|KD_UPF3B|UPF3A_ERP130413	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.1445
K562_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147557
Field CA3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15578
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.833839
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
prostate gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
increased freezing behavior	IMPC Knockout Mouse Phenotypes	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
hsa-miR-1304	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.84986
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.884246
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05727
Gordon Holmes syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362928
Huperzine A	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.22
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65565
endosomal part	GO Cellular Component Annotations 2015	1.0	null
liminal part of the r8 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18336
GATA2-21666600-HMVEC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
salivary gland	HPA Tissue Gene Expression Profiles	-1.0	-1.15546
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235909
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43202
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10685
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34457
COLO680N	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40827
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
A549_Bisindolylmaleimide IX_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172463
DCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56431
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981149
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-01A-12R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
horizontal nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08999
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4441
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4742-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS-273	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.89902
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hearing Impairment	DisGeNET Gene-Phenotype Associations	1.0	null
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-105	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Budding and maturation of HIV virion	Reactome Pathways 2014	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
NCIH660	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.53463
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12188
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03635
6849_PSMB1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23664
Low compliance bladder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
SP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54021
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.160948
19605494-TableS3	GeneSigDB Published Gene Signatures	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972432
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.954229
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30047
hsa-miR-19b	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
TET2_KO_GDS4287_431_mouse_GMP - bone marrow progenitor population	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.907689
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
ERK5-IN-2_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0134421
Superior central nucleus raphe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22529
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
membrane organization	GO Biological Process Annotations 2023	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32441
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45625
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304426
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65666
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SCAR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56989
pharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.944106
Perturb_987_KO_Eed_SRP092111	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.2491
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286487
NKX3-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95961
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880257
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65827
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36686
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3591-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ZBTB33_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952009
MDAMB453	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.18171
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.871279
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72946
r3 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80518
HCC202	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63308
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-1.29395
prostate	HPA Tissue Protein Expression Profiles	-1.0	-1.29395
BAG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22131
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28189
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269471
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.29395
Phosphatidylinositol 3-kinase complex, class III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.151
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62196
BBIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10067
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36686
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05206
1171_CAND1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546156
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06442
Perturb_4682_KO_Mll2_SRP189864	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.84202
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE129389_0_v_3_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
pontine nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34648
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44726
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75296
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7064
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13363
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.79861
Perturb_1812_KO_N4bp1_SRP255180	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.3098
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23528
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal coat/ hair morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09426
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRY	ChEA Transcription Factor Targets	1.0	null
MAFK_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.662
kyphosis	HPO Gene-Disease Associations	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46267
H3K27ac_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88772
strongly	GeneRIF Biological Term Annotations	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53334
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43859
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06365
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.08323
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.611747
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855379
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091659
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_14150_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S3XE-0626-SM-4AD6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834641
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.866932
Lung squamous cell carcinoma_LUSC_TCGA-85-A512-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14297
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COPII-coated ER to Golgi transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
Perturb_7328_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.89785
YPEL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13605
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26061
Microtubule organizing center	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.873913
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0412
artery disease	GWASdb SNP-Disease Associations	1.0	0.147258
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.265677
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.40146
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04072
Perturb_6904_KD_OTX2_SRP347033	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
Globus pallidus, internal segment	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14398
hsa-miR-3183	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-7769-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r10 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21123
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-7491-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.664769
GSE201217_4_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-137	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE48812_11_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
Perturb_8498_OE_Sox9_SRP375106	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.43652
abnormal coat/ hair morphology	MGI Mouse Phenotype Associations 2023	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SF126	Achilles Cell Line Gene Essentiality Profiles	1.0	2.12616
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
GTEX-U8XE-1826-SM-4E3HV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915374
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09896
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7824_KD_EWSR1_SRP106906	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.1051
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
escrt iii complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.839646
TCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1464
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism localization	GO Biological Process Annotations 2015	1.0	null
Field CA1, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05928
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
neurod1_17630985_pineal_gland_lof_mouse_gpl1261_gds3000	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.498641
Kidney Chromophobe_KICH_TCGA-KN-8419-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146588
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.554117
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20254
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.4893
hsa-miR-576-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910794
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_9_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
symbiosis, encompassing mutualism through parasitism	GO Biological Process Annotations 2015	1.0	null
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	3.197
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02911
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PV-01A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
endosome membrane	GO Cellular Component Annotations 2025	1.0	null
ZR7530	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13101
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Oral squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vascular disease	GWASdb SNP-Disease Associations	1.0	0.106732
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32663
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6742
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499635
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
lateral part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4596
K562_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018685
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_11_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TY-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958789
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27869
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-SI-AA8B-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WSU-DLCL2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36686
S1P_Deficiency_GDS3654_521_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05083
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-34c-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
gata4_18812176_jejunum_tissue_lof_mouse_gpl1261_gds3486	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.587155
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	GO Biological Process Annotations 2023	1.0	null
superficial stratum of r3BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19754
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299657
SRF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57976
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01367
Squamous Cell Carcinoma Of Esophagus	DisGeNET Gene-Disease Associations	1.0	null
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
r9 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29219
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832397
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51685
Hereditary spastic paraplegia 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.975
6855_PSMB6_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.62844
Perturb_4910_OE_NR5A1_SRP111466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.8339
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.02407
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tamibarotene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10895
hsa-miR-381	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.908308
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23341
epidermis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_5476_OE_Sox9_SRP375106	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.33764
GSE132313_1_v_0_fosl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the thorax	HPO Gene-Disease Associations	1.0	null
Ventral posterolateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13739
establishment of protein localization to membrane	GO Biological Process Annotations 2023	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7616-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55876
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966168
ERBB2_overexpression_230_GSE14990	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.69088
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34404
GTEX-QDT8-0926-SM-32PL2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18679
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96924
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
A549_Selisistat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129731
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Multivesicular body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.2
GTEX-VJYA-1226-SM-3GIJ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13777
ZEB1	ENCODE Transcription Factor Targets	1.0	null
GATA2-21666600-HMVEC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.970616
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6062_PAPOLA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506526
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63094
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85806
GSE196699_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859823
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A23T-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.81032
K562_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147559
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895362
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921091
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35552
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2750_ETF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.556263
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216538_1_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4517	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE128634,GSE128636_2_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r8 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10938
REST_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13497
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13318
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_13292_OE_Lima1_ERP128082	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.0995
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VENTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32188
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836925
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11824
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24597
GSE151364,GSE151366_1_v_2_taf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
medial (main) part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12432
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.243943
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326804
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.949368
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_256_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7q11 23 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
GTEX-TMZS-0126-SM-3DB9Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936481
Disease	Reactome Pathways 2014	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14903_KO_PRMT6_SRP125977	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.05018
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13611_KD_Puf60_SRP342713	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.09211
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4Z8-0726-SM-4GICB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00245
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01385
hsa-miR-27b	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73259
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85343
superficial stratum of DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64268
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015695
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
STAT3	ChEA Transcription Factor Targets	1.0	null
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.528096
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal embryo size	IMPC Knockout Mouse Phenotypes	1.0	null
10994_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10866
Kidney Chromophobe_KICH_TCGA-KL-8339-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease by infectious agent	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08261
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.8266
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2718
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46321
KMS-11/TKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.865
microtubule organizing center	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054424
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_22_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2231_KO_Irs1_SRP125007	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.43417
CREB1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9100_KD_Tfpi_SRP312891	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.1577
TRIM28	ChEA Transcription Factor Targets	1.0	null
cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094216
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36123
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.633663
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09639
RPS27A	Pathway Commons Protein-Protein Interactions	1.0	null
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.925621
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3928	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Perturb_6179_KO_Mecp2_SRP188207	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.17647
tendon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Amphisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.908
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1344
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-0.883807
electrocardiography	GAD Gene-Disease Associations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A64Q-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9547_UBR4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.640107
NAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12393
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71421
TE1_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.45619
Hereditary spastic paraplegia 43	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.794
dentate (lateral) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.996121
SMC3	ENCODE Transcription Factor Targets	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979704
957_C11ORF74_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520592
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56934
COLO783	CCLE Cell Line Gene CNV Profiles	1.0	1.9616
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
STAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07044
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGF1R_druginhibition_46_GSE14024	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.30238
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226784
PMC3470785-NIHMS377161-supplement-14.pdf-58-VDR_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_154_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36445
RPIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83843
PMC6099292__F5	PFOCR Pathway Figure Associations 2023	1.0	null
paraparesis	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PC3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.60906
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00712
HCC2814	CCLE Cell Line Gene Expression Profiles	-1.0	-2.35101
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854431
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
SmoothMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.69122
Perturb_7265_KO_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.2143
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.875662
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
OS-RC-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.299
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058366
TCF3-18467660-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_16936_KO_Krt19_SRP353487	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.82151
r4 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07393
FGFR1_drugactivation_149_GSE32316	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.10894
DYNLT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36643
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A1-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Corticospinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.328
Hereditary spastic paraplegia 49	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.831
RPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25207
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.937927
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_4905_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.56557
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.65244
PSN1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.32229
MAPK14_knockout_14_GDS2693	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.21922
Field CA3, stratum radiatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54325
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08075
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.865721
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.41022
intermediate part of r3B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26068
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21091
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.06225
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KCL22	CCLE Cell Line Gene CNV Profiles	1.0	1.79392
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-1.29395
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14353
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.45794
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40185
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86141
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7647
GTEX-OHPN-2726-SM-2I5H4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05325
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912551
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.884649
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.856941
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12192
GSE179002_3_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GATA2	ChEA Transcription Factor Targets	1.0	null
Perturb_3647_KO_KDM1A_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.39635
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_241_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.932669
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19034
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.935412
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4295	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFYB	ENCODE Transcription Factor Targets	1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CJM	CCLE Cell Line Gene Expression Profiles	1.0	1.94266
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5821
KLF4-25985364-ATHEROSCLEROSIS-LESION-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Superior central nucleus raphe, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12912
Perturb_12372_KD_SKP2_SRP297799	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99801
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635531
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79621
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.985224
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mammalian	GeneRIF Biological Term Annotations	1.0	null
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54121
superficial stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1275
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10739
Lung squamous cell carcinoma_LUSC_TCGA-21-1072-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123372,GSE123373_1_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15706
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.938848
Perturb_10360_KO_Arid5a_SRP288358	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.05068
USO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45582
SW1417	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6829
EBF1	ENCODE Transcription Factor Targets	1.0	null
A2058_SKIN	CCLE Cell Line Proteomics	1.0	7.02603
hsa-miR-4461	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
PNLDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21125
Lung squamous cell carcinoma_LUSC_TCGA-22-0940-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CORVET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05586
PCID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13886
Membrane Trafficking	Reactome Pathways 2024	1.0	null
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-148a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.05065
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28261
r10 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44103
Vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.69913
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
RFX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EFO-21	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.06929
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.79423
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.978256
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDVN-0926-SM-2I5GL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973699
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
layer 1 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73039
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8479_KD_CSDE1_SRP117243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.53405
Phagophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.0
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33373
MAFK	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DAOY	CCLE Cell Line Gene Expression Profiles	-1.0	-1.89303
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08486
pectus carinatum	HPO Gene-Disease Associations	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.19933
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.1062
Perturb_10279_KO_Lyplal1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.7312
RC-K8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.729
CL-40	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_14902_KO_Cdkn2a/Nf2/Bap1_SRP199809	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.27156
habenula (old epithalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73039
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.63468
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8203-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36686
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3329_GDF15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.558456
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15561_KO_SLFN11_SRP327912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.86818
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02395
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841975
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94559
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.34422
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4502	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
K562_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195597
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41583
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hypertension	GWASdb SNP-Phenotype Associations	1.0	1.00059
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4739739__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Vacuolar lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
ZBTB33_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19061
inner CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23606
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305972
Perturb_9684_KD_POU3F2_SRP242009	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.55773
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.842119
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
stratum pyramidale of caudal CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03481
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936135
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NR3C1_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940897
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
superficial gray layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04862
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
gait disturbance	HPO Gene-Disease Associations	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SIN3A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0116
autosomal recessive inheritance	HPO Gene-Disease Associations	1.0	null
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09427
granular layer of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38324
MEG01	CCLE Cell Line Gene CNV Profiles	1.0	1.47891
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06364
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.50422
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.59475
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
centrosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07142
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9563_KO_Ogt_SRP110508	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.02689
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.924559
GSE202434,GSE202438_10_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00282
HCC70	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.11641
GATA1_erythroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856085
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.37792
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4197
Vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.351
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67765
GSE183101_0_v_1_hvcn1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22174
Hereditary spastic paraplegia 30	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.846
JHOS-4	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.11641
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19655
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25625
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10599
MDAMB157_BREAST	CCLE Cell Line Proteomics	1.0	2.16993
Perturb_12579_KD_SMO_SRP254554	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.828076
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of muscle physiology	HPO Gene-Disease Associations	1.0	null
CAL-54	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.88305
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14825
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3228
IKZF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09307
SNU61	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76093
U343	Achilles Cell Line Gene Essentiality Profiles	1.0	1.0031
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Niemann-Pick disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19805
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11974
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QPCT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12851
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.875215
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.18859
SCC-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
Dystonia	DisGeNET Gene-Phenotype Associations	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.011614
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE80182_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7920-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1016_KO_Nt5e_SRP404924	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.20785
Meis1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16829
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53955
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302421
escrt complex	GO Cellular Component Annotations 2015	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
modification-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
NCIH716	CCLE Cell Line Gene Expression Profiles	1.0	1.50546
CTCF	ENCODE Transcription Factor Targets	1.0	null
Perturb_13921_KO_PPARGC1A_SRP314654	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.14905
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179031_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116429
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
cataract	IMPC Knockout Mouse Phenotypes	1.0	null
Chromaffin granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.629
Idiopathic Transverse Myelitis	DisGeNET Gene-Disease Associations	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4079-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13715
SR786	CCLE Cell Line Gene Expression Profiles	1.0	1.81765
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82721
NR2F2	ENCODE Transcription Factor Targets	1.0	null
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4282	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34833
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47311
multivesicular body organization	GO Biological Process Annotations 2025	1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18831
GNF-5	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.898745
K562_Toremifene Citrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015687
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HIV Life Cycle	Reactome Pathways 2014	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231246
abnormality of the nervous system	HPO Gene-Disease Associations	1.0	null
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95831
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.161068
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.882466
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06602
GTEX-QEG5-0626-SM-2S1PP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887641
GSE199255,GSE199356_3_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX3-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
protein targeting to membrane	GO Biological Process Annotations 2025	1.0	null
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234647_1_v_3_regorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_1654_KO_Irf1_SRP221603	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.37144
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827764
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520972
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.8656
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.2254
YIF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56049
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-302f	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
UBB	Pathway Commons Protein-Protein Interactions	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09046
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9439_KO_Mnx1_SRP239547	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.27313
H2AB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19677
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GTEX-XUJ4-1826-SM-4BOOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867714
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37792
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.112584
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56673
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00331
ADCY5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62365
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HEPG2	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.938144
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.56234
muscle	GTEx Tissue Gene Expression Profiles	1.0	1.6743
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.122979
vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZFX	ChEA Transcription Factor Targets	1.0	null
Oral mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.112
r9 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01691
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.853376
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975273
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.39535
LN428	CCLE Cell Line Gene Expression Profiles	-1.0	-2.59218
neurodevelopmental abnormality	HPO Gene-Disease Associations	1.0	null
Hereditary spastic paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
establishment of protein localization to membrane	GO Biological Process Annotations 2025	1.0	null
intracellular organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98109
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34039
r8 portion of ambiguous motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.4744
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CL-40	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2478
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
AQP11_Deficiency_GDS3395_578_mouse_Kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.04119
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
intermediate stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08183
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6216
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147697
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A64X-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02232
Brain disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
Blood Pressure	dbGAP Gene-Trait Associations	1.0	0.443956
hsa-miR-513a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33557
MCF7_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143565
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.834529
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4659b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
YY1	ENCODE Transcription Factor Targets	1.0	null
Perturb_4836_KO_Chd8_SRP306703	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.93827
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_4_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.876275
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52062
GSE199899_3_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12211054-spectrum.00100-25-s0002.pdf-57-USF2_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139966_4_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K8ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70677
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30405
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
G292CLONEA141B1	CCLE Cell Line Gene Expression Profiles	1.0	3.06831
hek293	HPA Cell Line Gene Expression Profiles	-1.0	-1.07472
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.967269
NFIC	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
18081427-TableS7	GeneSigDB Published Gene Signatures	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969319
SLC27A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31739
GTEX-WOFL-0826-SM-3MJG1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939044
r8 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19225
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05794
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
bortezomib_homo sapiens_gpl10558_gds4089	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24636
Autophagosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.759
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15465_OE_ETV4_SRP402451	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.13496
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
late endosome to vacuole transport via multivesicular body sorting pathway	GO Biological Process Annotations 2025	1.0	null
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36661
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3148	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
Lung squamous cell carcinoma_LUSC_TCGA-66-2770-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IDE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01332
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intermedioposterior nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36223
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7086-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_16651_KD_Fus_SRP179634	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.5706
K562_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148727
rostromedial tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01086
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X2-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OLIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06284
VPS37C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12405
hsa-miR-4748	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.927316
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2BK5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_16814_OE_HNF1A/FOXA3/PROX1/SIRT1/PGC1A/AMPK_SRP167105	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.5229
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37345
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136518
TCF21-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.957511
18451145-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.893433
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30628
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856085
STAT3	ENCODE Transcription Factor Targets	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054416
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27292
SJSA1	CCLE Cell Line Gene CNV Profiles	1.0	1.35683
Hereditary spastic paraplegia 35	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
Perturb_5094_KO_Cbx1_SRP104194	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.4913
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161723
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.4344
Olfactory tubercle, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15242
Glioma	DisGeNET Gene-Disease Associations	1.0	null
Field CA3, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33395
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	1.0	3.12887
mantle zone of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20955
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44Q-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9777_KO_Mettl6_ERP120512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.23674
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17787
UA-39-TN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25995
protein localization	GO Biological Process Annotations 2015	1.0	null
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.38415
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341569
superficial stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11647
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dorsal peduncular area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06996
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43327
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17137
hsa-miR-4708-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.777455
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09011
HSC3_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	2.28894
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08927
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.745214
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6765
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4763-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46458
SPOAN syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.887933
Autophagy	Reactome Pathways 2024	1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.90974
cytoskeletal part	GO Cellular Component Annotations 2015	1.0	null
GSE202434,GSE202438_10_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.880725
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06098
Perturb_13870_OE_LMO1_SRP093679	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.7291
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047635
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
5729_NOC2L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.701396
endosomal part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73054
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925708
GATA1	ENCODE Transcription Factor Targets	1.0	null
GSE114232_10_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ADH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29569
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35355
periventricular stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.07205
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303829
Field CA2, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10406
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	2.47435
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
K562_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145011
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HGC27_STOMACH	CCLE Cell Line Proteomics	1.0	2.25683
Perturb_1111_KD_Creb3l1_SRP255011	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.0373
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
olivary pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5887
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49024
synovial tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
5770_NPM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534391
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Synovial tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SUCS-1426-SM-4DM5W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26463
Perturb_3922_KD_VPS37A/VPS37C_SRP266781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_1446_KO_Tmem173_SRP221603	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.3687
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
microtubule cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_166_KD_Mir21_SRP361611	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.6706
granule cell layer of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70719
multi-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56464
SW620_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.11528
GSE210476_2_v_8_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186280_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
Autophagosome lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.62891
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26D-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Perturb_13150_KD_Atoh8_SRP241825	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.07656
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85027
Central lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03498
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6433-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	2.57061
Brain Lower Grade Glioma_LGG_TCGA-DU-7019-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cortical Dysplasia	DisGeNET Gene-Disease Associations	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.15229
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.038912
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Tegmental reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23406
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56506
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_36_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.87602
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NESCAV syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51151
Upper Limb Hypertonia	DisGeNET Gene-Phenotype Associations	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
bounding membrane of organelle	GO Cellular Component Annotations 2025	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
creb1_22108299_heart_left_ventricle_lof_mouse_gpl1261_gds3660	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.04174
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08305
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950334
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17666_KO_Smad2/Smad3_SRP137054	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.29408
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_71_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9896
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.534666
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27864
Perturb_16111_KO_Dnm2_SRP139918	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.76366
Lobule II	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10094
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
AP4B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26856
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15735
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.12035
MELK_knockdown_150_GSE32873	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.6038
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EG-06A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210770_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16628_KD_Sod1_SRP217736	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.4612
GTEX-P4QR-1026-SM-2I5GP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30276
Perturb_5390_KO_TYK2_SRP350422	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.47177
Pontocerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.4499
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PMC6099292__F5	PFOCR Pathway Figure Associations 2024	1.0	null
6846_PSMA6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.74065
RHBDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01582
Acute Myeloid Leukemia_LAML_TCGA-AB-2863-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.958472
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35752
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4666-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.19956
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CE-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.942611
1742_COG3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16442
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75136
Frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
Liver Cirrhosis	DisGeNET Gene-Disease Associations	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66Y-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Early endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.49
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02449
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H716	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.89241
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.892545
QGP1	CCLE Cell Line Gene Expression Profiles	1.0	2.43578
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08405
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.59288
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13409
ML-323	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DCP1A	ChEA Transcription Factor Targets	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A7CZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01998
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52027
PMC6607928-iovs-60-07-32_file_S11.xlsx-no_change_NRL_mutants-human_gene_ortholog_NRL	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasmic vesicle membrane	GO Cellular Component Annotations 2025	1.0	null
Paragigantocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22875
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.902902
Perturb_193_KD_Serpine2_SRP056340	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.6634
GSE99187_1_v_0_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_16501_KD_NEUROD1_SRP325888	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.1867
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Carcinoma, Hepatocellular_Hepatic Tissue_GSE4612	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.25543
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
MYO1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12199
Perturb_12959_KD_YTHDC1_SRP309987	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.49701
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56828
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endosome membrane	GO Cellular Component Annotations 2015	1.0	null
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.890034
K562_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164427
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49516
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42R-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU3F2	ChEA Transcription Factor Targets	1.0	null
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66111
Niemann-Pick disease type A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
laterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29528
Perturb_8166_KD_CNOT7_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.5245
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38386
hsa-miR-384	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
230_AKAP17A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572733
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3666	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13786_OE_IL10RB_SRP329434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.0464
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21403
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYD88_Deficiency_GDS2650_652_mouse_LUNG	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.34688
HMEL	CCLE Cell Line Gene Expression Profiles	-1.0	-2.46817
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04325
HDAC2	ENCODE Transcription Factor Targets	1.0	null
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34568
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Abnormality Of The Auditory Canal	DisGeNET Gene-Phenotype Associations	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211931_0_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053635
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SNARE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.391
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HGS	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38888
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02795
intracellular transport	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3065-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
Reticular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16096
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE221327_1_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09896
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
hsa-miR-137	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
hsa-miR-4795-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
r9 part of spinal trigeminal nucleus, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17302
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia 23	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
abnormality of the upper urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.167983
Lung adenocarcinoma_LUAD_TCGA-55-6983-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.955392
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_95_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.32969
Medullary reticular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26419
Perturb_7327_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.44721
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7253-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
PMC12529848-12967_2025_7217_MOESM3_ESM.xlsx-Table_S4-Table_S4_Associations_of_genetically_proxied_proteins_with_risk_of_atrial_fibrillation_by_MR-SPI_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE71385_1_v_2_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62356
MDAMB361	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67343
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFE184	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.09954
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01894
bounding membrane of organelle	GO Cellular Component Annotations 2023	1.0	null
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.93169
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25253
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
multi-organism process	GO Biological Process Annotations 2015	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34835
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
TTLL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2755
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59786
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77171
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1909
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8637-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.907893
Tendon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
multi-organism localization	GO Biological Process Annotations 2015	1.0	null
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42169
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2542
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11743
HGS	Hub Proteins Protein-Protein Interactions	1.0	null
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	2.30595
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35869
C1QL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.122
retrosplenial cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11969
Pontocerebellar hypoplasia type 2E	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
nucleus sagulum, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23169
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.962575
Nodulus (X), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09478
intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-548x	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Perturb_15195_KD_FXN_SRP313999	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
hsa-miR-301a	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
LMNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23751
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13019
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HG-A2PA-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.56068
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5309
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the vertebral column	HPO Gene-Disease Associations	1.0	null
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06686
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29513
Perturb_4904_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01045
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149063
Lung adenocarcinoma_LUAD_TCGA-05-4417-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W9-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.323002
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042731
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05626
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.4
KAT2A	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6876_PSMD8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1483
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Renal tubule epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
Prostate adenocarcinoma_PRAD_TCGA-HC-7230-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.77276
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2837
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.994941
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83109
abnormal muscle tone	HPO Gene-Disease Associations	1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ALKBH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40786
Lobule III	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01279
GTEX-U8XE-0626-SM-3DB8U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915899
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.27
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.214
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20X-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0032
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02701
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052997
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04777
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.39149
Neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
all	HPO Gene-Disease Associations	1.0	null
r2 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03185
SACM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15189
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_9285_KD_LMTK2_SRP276928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.05268
Cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PVOW-1026-SM-2XCF9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03544
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9857_WEE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.511624
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23387
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03396
r9 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96044
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LB2241-RCC	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.17463
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.2283
Perturb_1618_KO_Cebpb_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.95839
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10262
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-527	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.879976
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26671
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928191
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.60831
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892186
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
multivesicular body organization	GO Biological Process Annotations 2023	1.0	null
Perturb_5065_KO_H33a_SRP312364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
ChIP_CNOT3_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Electrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.572
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.62129
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXO3	ChEA Transcription Factor Targets	1.0	null
OCIAML3	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.57912
proteolysis involved in cellular protein catabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29364
Kyphosis Deformity Of Spine	DisGeNET Gene-Phenotype Associations	1.0	null
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828723
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A8AZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IA-LM	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.84181
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03226
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00464
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066111
GSE114992,GSE114993_8_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58012
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.252927
HS 839.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06446
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F6-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endoplasmic reticulum exit site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.207
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26845
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1341
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6558_POLR3D_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25931
ESCRT I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.983
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04054
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0634
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11852
GSE261563_3_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00463
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44O-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
late endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14717
anterior pretectal nucleus, dorsal superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24214
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.939561
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05835
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27684
Membrane binding and targetting of GAG proteins	Reactome Pathways 2024	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6941-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62196
hsa-miR-340	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
6858_PSMC2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2477
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein processing	GO Biological Process Annotations 2015	1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.860884
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.999508
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.59411
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.04868
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SKNMC	CCLE Cell Line Gene CNV Profiles	1.0	1.96805
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
hyperreflexia	HPO Gene-Disease Associations	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_14187_KD_RUNX1_SRP159178	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.9482
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.047
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3b_DirectGene_FOXA1-Data3b_Genes_directly_regulated_by_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.20393
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899986
Prostate adenocarcinoma_PRAD_TCGA-EJ-7785-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.70691
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_NANOG_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE89767_6_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NEF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.684
hsa-miR-130b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CEBPD_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKCO1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.14982
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32028
Perturb_5098_KO_Cbx5_SRP104194	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.41929
GSE142210_4_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25019
PSMB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24695
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04583
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1806	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73957
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.67355
NELFE	ENCODE Transcription Factor Targets	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10151
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.865522
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02904
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.826591
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10139
hsa-miR-4671-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
NFE2L1_02_32	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60792
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060798
KLC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45403
Lobule II, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16361
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52728
hsa-miR-148b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249194
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57312
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04565
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24843
egf	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CEP72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03523
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052286
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9249_KO_Setdb1_SRP332486	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Hyperreflexia In Upper Limbs	DisGeNET Gene-Phenotype Associations	1.0	null
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.35686
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
multivesicular body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.22153
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856085
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mantle zone of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5257
spastic	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4678	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.324114
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.878961
hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.85404
nucleoplasm	GO Cellular Component Annotations 2015	1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25857
hsa-miR-548a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
Bmi1_Deficiency_GDS4816_323_mouse_Primary lung cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZNF248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37164
GTEX-QMR6-1926-SM-32PL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13583
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.043005
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0929
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21576
SW954	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19951
Nodulus (X)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24514
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Paragigantocellular reticular nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34804
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.834138
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04797
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.699113
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis	HPA Tissue Protein Expression Profiles	1.0	2.38337
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169384
Lung squamous cell carcinoma_LUSC_TCGA-33-4538-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
centrosome	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09885
Cirrhosis	DisGeNET Gene-Disease Associations	1.0	null
outer CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.946372
late endosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SW1271	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84116
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.64427
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7370-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962627
Perturb_15871_KO_PAX3/FOXO1_SRP293781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Electrocardiography	dbGAP Gene-Trait Associations	1.0	0.319477
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04057
hsa-miR-3647-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A510-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58999
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894525
hindlimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.449116
escrt complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.057922
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22819
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC202	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50493
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
u2197	HPA Cell Line Gene Expression Profiles	1.0	1.15279
GTEX-U8XE-1026-SM-4E3HM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04679
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4462	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504744
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	3.15242
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.154624
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04302
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
CFPAC1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.03836
hypertrichosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.10258
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.4687
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43903
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11904
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.26385
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127091
GATA2-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10958
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859703
gracilis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.10712
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.115346
mantle zone of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22111
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5364
1583_CHMP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.655858
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02691
BLOC-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.646
Perturb_14156_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Muscle Hypertonia	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-T5JC-0526-SM-32PM7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920568
STX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12671
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-2278	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Dentate gyrus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56042
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24514
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18382
Cervical spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
ELP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66622
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856085
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	GO Biological Process Annotations 2023	1.0	null
ATF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-518a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.582621
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11375
K562_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190181
Perturb_8868_KD_PNN_SRP063860	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.38612
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43439
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03562
GSE111247_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.190168
abnormality of the kidney	GWASdb SNP-Phenotype Associations	1.0	1.00059
escrt complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.433604
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-1726-SM-48FDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924178
Kidney Chromophobe_KICH_TCGA-KL-8337-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924229
H4K20me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4909989-ncomms11840-s2.xlsx-up-regulate-The_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_regulated_genes_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Autophagosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.218
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90001
GTEX-POYW-1226-SM-2XCEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38707
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06969
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.98876
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.44491
496100604_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.09361
JMSU1_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.41675
Mon1-Ccz1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.859
Epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_9725_OE_PCX_SRP255647	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
RMUGS_OVARY	CCLE Cell Line Proteomics	1.0	2.18575
PLB985	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.18974
recessive	GeneRIF Biological Term Annotations	1.0	null
SLR20	Achilles Cell Line Gene Essentiality Profiles	1.0	1.0842
Perturb_13939_KO_USP29_SRP329795	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.61986
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
catabolic process	GO Biological Process Annotations 2015	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREM	ChEA Transcription Factor Targets	1.0	null
KMS34	CCLE Cell Line Gene CNV Profiles	1.0	1.75642
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223177
hsa-miR-548am	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H4K20me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nucleus ambiguus, ventral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37349
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4746
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67021
CP 94253	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.939738
GTEX-SIU7-0926-SM-4BRX1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885093
Infertility, Male	CTD Gene-Disease Associations	1.0	1.10838
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.70746
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE182834,GSE182836_2_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.222699
spinal trigeminal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.012
GSE184087_0_v_3_tert_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nodulus (X), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4369
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.77234
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888279
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ONCODG1	CCLE Cell Line Gene CNV Profiles	1.0	2.00447
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IRF4_01_262	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61294
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.60169
r2 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19225
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22467
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18529
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8734
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041031
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067764
PMC11574300-41698_2024_702_MOESM1_ESM.pdf-29-TTF1_TTF1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_12083_KO_Trp53_DRP003641	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.55962
Hereditary spastic paraplegia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.594
microtubule organizing center	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-548k	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SNU620	CCLE Cell Line Gene CNV Profiles	1.0	1.37452
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058107
GTEX-T8EM-1126-SM-3DB7D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933404
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05839
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
b220.bcell	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.85861
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26068
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.954622
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.004469
DCP1A-22483619-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SRF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SGI-1776	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KURAMOCHI	CCLE Cell Line Gene Expression Profiles	-1.0	-2.34812
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061282
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129244_0_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05017
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.096498
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52174
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.074276
GSE128240_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.73257
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.891667
Prostate gland epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06383
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14153_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3ET-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
GTEX-P44H-0326-SM-2XCES	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8419
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02147
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919709
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3200-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
GSE228992_0_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053138
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49662
Perturb_4841_OE_Gfi1/Pou4f3_SRP220284	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.21695
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188608
ME1	CCLE Cell Line Gene Expression Profiles	1.0	1.63723
GSE158834_10_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08427
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0619
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.99143
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.895827
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47401
FOXA1	ENCODE Transcription Factor Targets	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9086029__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932001
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36686
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsal part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.30427
Synthesis And Processing Of GAG, GAGPOL Polyproteins	Reactome Pathways 2024	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32166
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19773
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03433
GTEX-PX3G-1526-SM-48U11	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851115
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.8979
GSE62843,GSE64370_4_v_1_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2004
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20545
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4422	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22604
pronephros	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.584022
intermediate stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07871
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
Infertility, Female	CTD Gene-Disease Associations	1.0	1.24433
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DMB	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.5
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3920_KD_VPS37A/VPS37B_SRP266781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11922
9687_UTP6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532437
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24007
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CT-01A-31R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1739
Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Seratrodast	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20784
hsa-miR-4307	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
spi1_17041602_preleukemic_hscs_lof_mouse_gpl1261_gds2411	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.832837
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.82756
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-301b	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
pallidal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13404
PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
r4 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03126
cytoskeletal part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
RBBP5	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
decreasing	GeneRIF Biological Term Annotations	1.0	null
A253	CCLE Cell Line Gene Expression Profiles	1.0	2.2044
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3140-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Perturb_8787_KO_HNF6_SRP217514	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.19006
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01046
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24507
MCF7_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00951392
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-01A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE145915_3_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal recessive spinocerebellar ataxia 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64471
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4QS-1026-SM-3NMCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04556
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108535
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18724
GSE158834_1_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37381
SRF	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.03049
ME1	CCLE Cell Line Gene CNV Profiles	1.0	2.36533
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73765
XRCC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15945
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01719
Internal plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13776_KD_IFNAR2_SRP329434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.88239
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infectious disease	Reactome Pathways 2024	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.89472
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072593
hsa-miR-4661-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.969981
E2F1	ChEA Transcription Factor Targets	1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased body length	MGI Mouse Phenotype Associations 2023	1.0	null
A549_PCI-34051_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0109837
MAT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07836
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10760404-NIHMS1688779-supplement-Supplementary_Table_S6.xlsx-EMP_CREB_Targets-symbol_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.824633
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339615
GSE255432_4_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35142
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134206
Transverse myelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042261
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.11914
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.937187
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-622	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981694
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22123
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Field CA2, stratum radiatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39307
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0831
GSE148066,GSE157787_5_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.831687
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4666-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_236_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572152
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15409
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_7232_KO_ADIPOR2_SRP285935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.14668
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
Hecv	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial part of r4B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54536
REST_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 46	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
Microtubule cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.613
PMC8370976-41467_2021_24932_MOESM6_ESM.xlsx-Annotation-Supplementary_Data_4_GO_and_metascape_analysis_of_the_genes_downregulated_in_U87_cells_upon_ZNF768_knockdown_ZNF768	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4N-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3862
Perturb_1395_KO_Upf2_SRP351098	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.39247
retrotrapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28877
NCIH358	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47217
NCIH226	CCLE Cell Line Gene Expression Profiles	1.0	1.56642
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	1.0	1.49694
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836478
GB1_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	3.3877
Perturb_9466_KO_Kmt2b_SRP162549	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.42472
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60049
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949501
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F2-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4596
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930835
Perturb_7233_KO_ADIPOR2_SRP285935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.73763
10721_ZSCAN29_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.593895
abnormality of cardiac morphology	GWASdb SNP-Phenotype Associations	1.0	1.00059
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63648
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38342
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25993
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SRP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20222
ZFX-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36686
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE57397,GSE57399_1_v_0_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
THP1	CCLE Cell Line Gene CNV Profiles	1.0	1.3677
Cerebral Ventriculomegaly	DisGeNET Gene-Phenotype Associations	1.0	null
SASS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04509
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7220-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-183	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
hsa-miR-362-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
PPARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62416
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Membrane Trafficking(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156403
16705090-TableS2	GeneSigDB Published Gene Signatures	1.0	null
AD-34-TG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.357396
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-RNA-Seq_analysis_of_genes_associated_with_a_DHS_that_has_a_CEBPAx2_specific_Hi-C_interaction_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-0226-SM-48U28	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865288
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59681
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.514854
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.723696
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IG-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.4
GFAP_OE_GDS1488_254_mouse_Olfactory bulb of 23 day old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
placenta_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.01429
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45953
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36686
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12856
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HS578T	CCLE Cell Line Gene Expression Profiles	1.0	1.64525
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292306
neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051384
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2882
GSE186483_1_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	GO Biological Process Annotations 2025	1.0	null
GSE247764_3_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.51499
hsa-miR-599	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1207-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4137
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45P-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
3448_GNPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.30158
Perturb_13490_KD_Ncor1_ERP132013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.062
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46148
Perturb_7389_KO_UPF3A_ERP130415	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.63228
Perturb_5154_KO_Dcr_SRP038929	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.73197
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K23ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NLGN4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35486
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RCOR1	ChEA Transcription Factor Targets	1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.51807
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.341495
PMC7898758-40168_2020_994_MOESM4_ESM.xls-STAT1_target_genes-Gene_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.925803
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.92003
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.45299
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857309
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.0471
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44265
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RP1_KO_GDS1845_190_mouse_Retinas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MECP2_KD_GDS4759_334_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
viral process	GO Biological Process Annotations 2015	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08815
NCIH209	CCLE Cell Line Gene CNV Profiles	1.0	1.5235
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_5_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31056
Perturb_7558_Mut_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.37229
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_16500_KD_ASCL1_SRP325888	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.20194
Perturb_7153_KD_MOV10_SRP029367	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.12155
GSE114232_8_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSK2578215	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
ESCRT I complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.45383
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.31416
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32033
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CWF19L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48785
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15039
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_16108_KO_Dnm2_SRP139918	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.65836
Lung adenocarcinoma_LUAD_TCGA-86-8674-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944817
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7456_KO_DHX36_SRP120501	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.5806
transport of virus	GO Biological Process Annotations 2015	1.0	null
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LTBR_INHIBITION - 2 Days_GDS2005_729_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.3087
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02383
hsa-miR-548t	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_4_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880257
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X88G-0326-SM-47JZ4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919431
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876971
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51561
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE190235_1_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111247_2_v_9_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.76966
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-383	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Perturb_7291_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.32969
subunit	GeneRIF Biological Term Annotations	1.0	null
cataract	MGI Mouse Phenotype Associations 2023	1.0	null
estradiol_homo sapiens_gpl570_gse23610	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r3 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09801
hsa-miR-203	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
Infralimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1289
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054932
hsa-miR-591	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45342
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046532
EP300_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29067
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890042
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP3K6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11687
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03952
Sorting endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
Cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MYOD1_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3853418-1756-8935-6-34-S2.pdf-4-ZNF596_ZNF596	Rummagene Transcription Factor Associations 2026	1.0	null
MBTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31877
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8507-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A8YF-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.59738
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21813
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2980_KD_Mbnl1/Mbnl2_SRP057123	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.90202
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AKT1_activemutant_10_GDS2304	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.45711
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13045
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42965
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NQ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.5863
Perturb_12309_KD_METTL14_SRP074429	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.2256
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850494
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18333
escrt i complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
r11 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63231
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017842
GTEX-PX3G-0926-SM-48U12	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859681
GSE169571_5_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28177
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52209
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
Endosomal Sorting Complex Required For Transport (ESCRT)	Reactome Pathways 2024	1.0	null
protein transport	GO Biological Process Annotations 2015	1.0	null
Endolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.656
GSE153258_1_v_0_dcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
DANG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68062
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00937
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.62974
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESCRT II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.406
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06933
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254438
Microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
superior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.09585
Meiotic prophase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
hsa-miR-454	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918621
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.08448
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2899
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86776
GSE218814_1_v_0_suv39h1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dystonia	HPO Gene-Disease Associations	1.0	null
hsa-miR-19a	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914637
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03168
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.41243
Perturb_7494_KD_DICER1_SRP186271	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.89101
Hippocampal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19935
ATF2	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mIMCD-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.53
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2722-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1071-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
skin cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208779
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949603
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.988901
GSE148066,GSE157787_2_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00335
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09707
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-449a	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7515907__F3	PFOCR Pathway Figure Associations 2023	1.0	null
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84849
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.553614
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
JHOS4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.52746
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.51844
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
3654_HBS1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.818031
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898379
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.74299
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 75	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
GSE131887_1_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13792
downregulation	GeneRIF Biological Term Annotations	1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230357
hsa-miR-3646	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00338
Parkinson's Disease_Substantia Nigra_GSE7621	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.83261
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.85098
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257696
Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
Perturb_8417_KO_Srsf1_SRP252896	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.30555
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35924
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein targeting	GO Biological Process Annotations 2025	1.0	null
mantle zone of PcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.29765
GTEX-REY6-1426-SM-48FDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22917
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01793
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91977
ELK1	ENCODE Transcription Factor Targets	1.0	null
neurodevelopmental delay	HPO Gene-Disease Associations	1.0	null
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960374
Perturb_13866_KD_KDM6B_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.0466
hsa-miR-548e	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
KDM1A	ENCODE Transcription Factor Targets	1.0	null
DANG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58198
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-11A-01R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3629_KO_HDAC3_SRP355605	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.88655
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.4458
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889305
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4699-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4391
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.406969
Vacuolar HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.706
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114967
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia 37	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.608
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3582
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00429
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07118
Oropharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
FOXP1_01_88	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60752
Perturb_14718_KO_Bma1_SRP351647	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38848
CEBPD	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04896
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051858
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
9753_VPS37A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.517774
Helam	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.117
Squamous Cell Carcinoma Of Oropharynx	DisGeNET Gene-Disease Associations	1.0	null
BT549	CCLE Cell Line Gene CNV Profiles	1.0	1.51031
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Perturb_9694_KO_GPNMB_SRP382180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
medial part of r3B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5257
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40435
ALG2	Pathway Commons Protein-Protein Interactions	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEIS1	ChEA Transcription Factor Targets	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MU-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13518_KD_ILF2_SRP077068	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.93698
hippocampus (cortex Ammonis)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00834
H3K36me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01871
precentral gyrus, right, inferior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.900948
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.922766
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55F-1426-SM-2TF53	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06575
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058477
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
Cell envelope Sec protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.603
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60266
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38556
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9916
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.93121
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H4K20me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SERF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03021
Perturb_13043_KD_TARDBP_SRP069787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.83959
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
isthmic roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.19379
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.003463
MOLM13	CCLE Cell Line Gene CNV Profiles	1.0	1.60048
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.949866
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.66713
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88251
PML	ENCODE Transcription Factor Targets	1.0	null
mantle zone of CoPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11654
SRF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2244
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828636
HCC38	CCLE Cell Line Gene CNV Profiles	-1.0	-2.02641
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.976824
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clonus	HPO Gene-Disease Associations	1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.03266
transport	GO Biological Process Annotations 2015	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRO-0326-SM-33HBM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946998
Acute Myeloid Leukemia_LAML_TCGA-AB-2821-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_125_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
A253	CCLE Cell Line Gene CNV Profiles	1.0	2.56392
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824785
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3151
Endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.556
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.30011
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276007
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE193334_1_v_0_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7864-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51062
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TZM-bl cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
GTEX-QLQW-0126-SM-447BK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830659
TCOF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05393
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	GO Biological Process Annotations 2025	1.0	null
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04243
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07775
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10359315-41598_2023_37732_MOESM1_ESM.pdf-1-ZNF770_ZNF770	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
SW1116	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66197
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13238_KO_Flcn_SRP126727	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.2258
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46414
SNU840	Achilles Cell Line Gene Essentiality Profiles	1.0	1.23424
PMC7288929-aging-12-103203-s002..xlsx-downregulated_by_BCL6-TargetID_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Dentate gyrus, granule cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58332
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6010-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Amyotrophic lateral sclerosis type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.442
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.09947
HPAFII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67269
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_30_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-XK95-0426-SM-4AT4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91026
Perturb_9411_KD_Pcbp1_SRP251371	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.65728
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.82692
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.37871
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3a_DirectGene_CEBPA-Data3a_Genes_directly_regulated_by_CEBPA_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
microtubule organizing center	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90188
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.34902
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.14996
escrti	GeneRIF Biological Term Annotations	1.0	null
DCP1A-22483619-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
cerebellar vermis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.909947
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.07832
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855379
Perturb_13902_KO_AS3MT_SRP332674	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.35968
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.87608
EFM19	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40338
496100602_TCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41757
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.787745
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cytoplasmic vesicle membrane	GO Cellular Component Annotations 2023	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
synovium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-4703-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
ATF3	ENCODE Transcription Factor Targets	1.0	null
Perturb_4603_KO_Mst_SRP246200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.29984
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MEIS1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
multi-organism transport	GO Biological Process Annotations 2015	1.0	null
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.944444
ATF3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017186
Lobule III, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01713
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	68.9233
PMC5527948__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00957
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
6869_PSMD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.68792
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06738
MRE11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1842
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.190814
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.139119
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3919_KD_VPS37A_SRP266781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Lung adenocarcinoma_LUAD_TCGA-50-5051-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_16626_KD_Sod1_SRP217736	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.70773
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.057218
Nem1-Spo7 phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.865
r2 part of prepontine raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06758
CHD2	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03463
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887393
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02639
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31369
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08554
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane fission	GO Biological Process Annotations 2023	1.0	null
Uvula (IX), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11185
hsa-miR-2909	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nb100	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.99
abnormal pyramidal signs	HPO Gene-Disease Associations	1.0	null
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
upper motor neuron dysfunction	HPO Gene-Disease Associations	1.0	null
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152572
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.379123
cellular component organization	GO Biological Process Annotations 2015	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963777
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51513
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3916	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
UAP1	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of r8Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66852
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Myelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
GFI1B	ChEA Transcription Factor Targets	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00302
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC2965092-pone.0013658.s001.xls-Liangos_SOM_Table1-GeneName_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
late endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.978559
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08687
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827764
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7628_KD_HNRNPL/UPF1_SRP129007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.79112
hsa-miR-143	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1944_LUNG	CCLE Cell Line Proteomics	1.0	5.63218
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997598
JUN	ENCODE Transcription Factor Targets	1.0	null
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_4843_OE_Gfi1/Pou4f3/Atoh1_SRP220284	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.14036
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WI4N-1126-SM-3LK7Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875888
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36943
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75481
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26619
hereditary	GeneRIF Biological Term Annotations	1.0	null
integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055042
MCF7_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160567
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43655
FOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18779
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.852711
NPIPB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25301
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886566
Oropharyngeal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
C-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_171_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
melanoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2544
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-449b	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t67-small-intestine_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.84758
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA3-24758297-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
CABP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09955
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927402
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.249329
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.21534
GTEX-WH7G-2026-SM-3NMBL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892625
23132/87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endosomal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.26604
GATA1_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t67-small-intestine_female_1w	MoTrPAC Rat Endurance Exercise Training	1.0	2.00093
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.112
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23686
Perturb_7316_KO|KD_UPF3A_ERP130416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.20103
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_15_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3673	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE101748_0_v_1_apela_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r8 part of linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04003
ECC10	CCLE Cell Line Gene CNV Profiles	1.0	1.49246
Endosomal Sorting Complex Required For Transport (ESCRT)	Reactome Pathways 2014	1.0	null
Parasubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14462
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_18_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09677
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
Perturb_5340_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP337936	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.37482
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2977_FASTKD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623725
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81173
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.963991
Global Developmental Delay	DisGeNET Gene-Disease Associations	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.581727
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68A-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841138
GTEX-VUSG-0926-SM-3GIK6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34446
Budding and maturation of HIV virion	Reactome Pathways 2024	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.57756
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_6235_KO_Mbnl1/Mbnl2_SRP058351	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.32807
6850_PSMB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42083
Perturb_5216_KO_Bap1_SRP162521	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.87735
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.4528
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.963216
placenta_6c	HPA Tissue Sample Gene Expression Profiles	1.0	0.968867
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054551
endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894893
Prostate adenocarcinoma_PRAD_TCGA-EJ-7781-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4659a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03958
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Perturb_14154_KD_RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.4141
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38001
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A89Z-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gracilis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.886
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IGR39	Achilles Cell Line Gene Essentiality Profiles	1.0	1.68395
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73838
GSE146982_3_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135352_6_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.947437
protein targeting to membrane	GO Biological Process Annotations 2023	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03445
GSE62843,GSE64370_0_v_1_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.28534
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066439
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9776_KO_Mettl6_ERP120512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.458
A549_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013248
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39868
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86282
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-128	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ISTMES2	CCLE Cell Line Gene Expression Profiles	1.0	2.1772
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.72915
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7600_KO_LEF1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.44908
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256267
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.7738
Melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MYB_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_13_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1428	CCLE Cell Line Gene CNV Profiles	-1.0	-2.0761
PAX5	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00937
SCID - Severe combined immunodeficiency_Lung Tissue_GSE3414	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.60237
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.864037
LAMA84	CCLE Cell Line Gene Expression Profiles	1.0	2.02246
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_82_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962726
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	1.02676
ABCB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33643
Clonus	DisGeNET Gene-Phenotype Associations	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0058
Prostate adenocarcinoma_PRAD_TCGA-HC-7232-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
time of death	GWASdb SNP-Phenotype Associations	1.0	1.00059
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64667
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.914961
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_13255_KD_Paf1_SRP083772	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.23208
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06944
PMC9927941-jci-133-163612-s045.xlsx-Sheet1-Table_S11_DEGs_with_a_PAX5_binding_motif_as_identified_by_Pscan_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19047
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_17_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347034
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
substantia nigra, reticular part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.952483
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Field CA2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13827
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16502_KD_ASCL1_SRP325888	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.82321
Perturb_13613_KD_Puf60_SRP342713	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.23642
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
sensory peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.817976
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.51042
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00064
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83827
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RO-01A-12R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882977
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.829206
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HT29	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13189
superficial stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80127
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47008
phenotypic abnormality	HPO Gene-Disease Associations	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
6493_PNO1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14646
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.919723
AZD 6482	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cellular catabolic process	GO Biological Process Annotations 2015	1.0	null
CREB1	ChEA Transcription Factor Targets	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93619
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.19666
PMC10652340-ACEL-22-e13915-s007.xlsx-PBX1-SYMBOL_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43783
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8054-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100401_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00643
dorsal spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34676
H3K79me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186460_0_v_2_baricitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
prostate gland epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14147_KD_RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.68958
ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2025	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of skeletal morphology	HPO Gene-Disease Associations	1.0	null
Tonometry	GWAS Catalog SNP-Phenotype Associations	1.0	0.165905
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09849
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07383
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7516_KO_TFAM_SRP213924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.758
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81Q-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-301a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.27224
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8517_STK24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.645081
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.77764
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052883
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MH-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20287
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21662
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97723
Perturb_4474_OE_Smn_SRP258674	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.26692
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.833786
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09574
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.929354
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
causes	GeneRIF Biological Term Annotations	1.0	null
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82844
hsa-miR-4760-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
496100360_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22773
ovary cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.572818
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856085
Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05184
Hereditary spastic paraplegia 39	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.15
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.883506
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73004
Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3133	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
Centriolar satellite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053184
Dilated Ventricles (Finding)	DisGeNET Gene-Phenotype Associations	1.0	null
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
Perturb_7363_OE_RBFOX1_SRP307800	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.8479
6841_PSMA1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16271
Charcot-Marie-Tooth disease type 1C	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
GSE128730_4_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Abscission zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
NCIH211	CCLE Cell Line Gene CNV Profiles	1.0	1.55043
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.546729
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37886
molecular layer of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62362
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2023	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_21_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29862
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65894
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.566678
Perturb_1415_KD_Smc1a_SRP062844	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.05379
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16604_KO_Phb_SRP229743	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.77602
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17285
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.32092
GOLPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30384
RS411	Achilles Cell Line Gene Essentiality Profiles	1.0	1.22238
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HPAFII	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79616
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910227
neurodegenerative disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-1.60606
hsa-miR-1305	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4271336-13041_2014_88_MOESM6_ESM.xlsx-Genes_in_GENE_CARD_MR_or_ID-Gene_Cards_MR_and_ID_genes_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
COR-L303	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	53.507
K562_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238272
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GATA4-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26809
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4770	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19681
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.83661
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3666	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.963991
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.870025
GATA2-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Vesicle-mediated transport	Reactome Pathways 2024	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.437906
GSE231799_3_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16733_KO_Hpgd_SRP049141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.48266
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-WK-A8XZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12074_OE_Carm1_SRP134253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.76723
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAV1_Deficiency_GDS3551_559_mouse_Hearts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC3419980-leu201249x4.xls-H3K9Ac-RUNX1ETO_peaks_2fold-All_gene_regions_overlapping_with_RUNX1-ETO_peaks_changing_histone_acetylation_more_than_2-fold_after_knock-down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87436
Perturb_7315_KO_UPF3A_ERP130416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.04224
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4354-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_Activation - 8 hours_GDS2025_725_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882977
Modifier of rudimentary, Modr	InterPro Predicted Protein Domain Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.869645
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.955306
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.29395
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07237
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22782
GSE97278,GSE97280_2_v_3_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST	ChEA Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-7637-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12763
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2758-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351765
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966749
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18117
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044649
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115689
CEBPB_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endosome	LOCATE Curated Protein Localization Annotations	1.0	null
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04862
Tonometry	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5823_KO_Ebf1_SRP095167	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
MRPL50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08666
LU99	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63503
ESCRT IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.059
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13222_KO_Hdac3_ERP123505	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.85874
Prion disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
5677_NIPBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.514476
Dentate gyrus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50132
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042003
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50208
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
abnormality of the sternum	HPO Gene-Disease Associations	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.98838
superficial stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1307
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.920451
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17605
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85343
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.34844
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hereditary spastic paraplegia 78	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.9
PMC5527948__F1	PFOCR Pathway Figure Associations 2023	1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051246
hsa-miR-3125	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
protein complex	GO Cellular Component Annotations 2015	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
HT-1080	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.21567
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
zonal layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06688
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
microtubule cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-OHPL-1026-SM-3MJGI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0626
oropharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.01554
Perturb_1006_KO_Bcl9l/Bcl9_SRP045828	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.12706
OCUM1	CCLE Cell Line Gene CNV Profiles	1.0	1.40787
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-587	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
hilus of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41139
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
r4 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43149
GTEx SmallIntestine 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	3.36717
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18362
APP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_17806_KO_ZNF675_SRP304971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.33733
Neuromyelitis optica	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
GTEX-XV7Q-2926-SM-4BRUL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49447
leg muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.303919
NCI-H1944	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1217
KDM5A	ENCODE Transcription Factor Targets	1.0	null
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
Perturb_12036_KD_Prmt6_SRP131294	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.29015
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158598
Late endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.094
Lung adenocarcinoma_LUAD_TCGA-53-7813-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564563
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TGBC1TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45026
Hereditary spastic paraplegia 28	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.554
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.74144
H3K36me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VPS28	Pathway Commons Protein-Protein Interactions	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
abnormality of the musculature	HPO Gene-Disease Associations	1.0	null
JHESOAD1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.46122
Thoracic spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76034
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.41668
Perturb_6764_KO|KD_SERPINE2_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.4443
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846606
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lateral posterior nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17317
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31299
marc145	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.799
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-NR2F1_Ind_UP_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
6853_PSMB5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4784
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.62148
TAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00756
hypertonia	HPO Gene-Disease Associations	1.0	null
intracellular transport of virus	GO Biological Process Annotations 2015	1.0	null
GSE148692,GSE148695_5_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37788
Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838879
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Late Phase of HIV Life Cycle	Reactome Pathways 2014	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
JAK2_activemutant_72_GSE21842	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.55909
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270505
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37261
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35166
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.8423
Perturb_8038_KO_FOXA2_SRP350523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.58856
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1887
TRAPP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.073
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28644
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.5852
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DW-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12075_OE_Prmt1_SRP134253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.40572
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterior horn cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.903
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
esr1_21713035_mcf7_lof_human_gpl570_gds4061	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-2.34218
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856085
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.967053
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5541_KO|KD_Fh1|Foxa2_ERP138019	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.66436
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.944169
hsa-miR-1273f	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053137
DUSP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10386
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.39829
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.134
liver	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15319
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.51424
HCMV Infection	Reactome Pathways 2024	1.0	null
PMC6607928-iovs-60-07-32_file_S11.xlsx-no_change_NRL_mutants-latefoetal_NRL	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinoma, Ovarian Epithelial	DisGeNET Gene-Disease Associations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2822-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867817
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NB-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ubiquitin-conjugating enzyme/RWD-like	InterPro Predicted Protein Domain Annotations	1.0	null
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15913
Late endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K36me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04567
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.219
NFYA	ENCODE Transcription Factor Targets	1.0	null
Perturb_7487_KD_SUPT4H1_SRP166802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.57072
K562_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149402
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r3 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40375
Brain Lower Grade Glioma_LGG_TCGA-IK-7675-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5442-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Central vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.586
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.16221
6863_PSMC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32202
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.197766
Perturb_6624_KD_DDX5_SRP237546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69721
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904492
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3125	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.890655
hsa-miR-4669	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A549_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142768
intermediate part of r4B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17124
HT29	CCLE Cell Line Gene Expression Profiles	-1.0	-2.50699
Adrenocortical carcinoma_ACC_TCGA-OR-A5JR-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.16591
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.421351
Lytic vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.304
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0926-SM-4BOPI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979661
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dronedarone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.6
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AH-0926-SM-48TZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839992
Late endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
D-542MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Renal clear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6027-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-301b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
hsa-miR-148b-3p	MiRTarBase microRNA Targets	1.0	null
hsa-miR-3916	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4295	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
superficial stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24514
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6YA-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.091
GTEX-VUSG-0726-SM-3GIK1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26043
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4731-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58756
salivarygland_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.900217
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28017
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77999
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.997827
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840547
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1355
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.39499
bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.065222
SIX5	ENCODE Transcription Factor Targets	1.0	null
SB-269970	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
BLOC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.721
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
vacuolar transport	GO Biological Process Annotations 2025	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984156
cervical carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087296
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041364
membrane organization	GO Biological Process Annotations 2015	1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977444
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4934_OE_KLF17_ERP131959	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.21548
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12504
Perturb_4962_KO_Dot1l_SRP214101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-17.8356
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.976219
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.78098
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39532
hsa-miR-4633-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE261563_2_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041669
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	0.110462
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.02331
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AE-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_198_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.29211
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_18014_KO_miR19a/miR19b1_SRP050491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.52301
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.14611
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14194_KO_ALPG_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.9206
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48438
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.998449
PMC9691391-7945884.f3.pdf-45-ENSG00000008441_NFIX	Rummagene Transcription Factor Associations 2026	1.0	null
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2276_DNAJA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.615003
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.58492
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73147
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1937
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane organization	GO Biological Process Annotations 2025	1.0	null
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.951545
Lung squamous cell carcinoma_LUSC_TCGA-66-2773-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17608
increased freezing behavior	MGI Mouse Phenotype Associations 2023	1.0	null
Bradyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
ATF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28644
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraparesis, Spastic	DisGeNET Gene-Phenotype Associations	1.0	null
hsa-miR-3662	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GALNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08294
9073_TMEM41B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.688533
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14674
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053635
HCMV Late Events	Reactome Pathways 2024	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 15	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13909
FLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12727
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978084
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	3.14036
ANKRD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53518
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233679_5_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86895
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
principal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14783
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Brain Lower Grade Glioma_LGG_TCGA-HT-7482-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98037
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16543
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00889
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r7 part of the nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04879
2731_ESF1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.755506
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27186
PMC11223007-Supplementary_Data.pdf-28-THAP12_THAP12	Rummagene Transcription Factor Associations 2026	1.0	null
r3 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19397
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36686
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thigh muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.488276
macroautophagy	GO Biological Process Annotations 2023	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral hypothalamic area, anterior part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.933326
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35557
MAZ	ENCODE Transcription Factor Targets	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057702
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
HS822T	CCLE Cell Line Gene Expression Profiles	1.0	1.3964
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44686
blood pressure	GAD Gene-Disease Associations	1.0	null
DTX3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33108
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_4326_KO_Zcchc8_SRP187429	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.76404
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1293
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09208
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30154
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23728
MOLM13	CCLE Cell Line Gene Expression Profiles	1.0	1.77665
PL21	CCLE Cell Line Gene Expression Profiles	1.0	1.58528
E2F6	ENCODE Transcription Factor Targets	1.0	null
Microtubule organizing center	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.613
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
centrosome	GO Cellular Component Annotations 2015	1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.206082
MCF7_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00910104
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE88819_6_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of the curvature of the vertebral column	HPO Gene-Disease Associations	1.0	null
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.31103
connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65267
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.8888
Entorhinal area, medial part, dorsal zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27472
GSE235644_1_v_0_fasn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Membrane Trafficking	Reactome Pathways 2014	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6546
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Late endosomal microautophagy	Reactome Pathways 2024	1.0	null
Dentate gyrus, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90262
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16201
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
layer 2 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78161
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31597
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24211
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arcuate nucleus of medulla, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17971
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoskeletal part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.8484
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02067
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83205
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
ChIP_KLF4_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56927
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	171.661
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20531
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.82832
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03759
NAALADL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0537
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21933
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33628
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.867421
HCC70	CCLE Cell Line Gene Expression Profiles	-1.0	-2.15667
lysosomal	GeneRIF Biological Term Annotations	1.0	null
GSE214823,GSE214824_6_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02691
SETDB1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2591	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.23521
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42583
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D1-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171572_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsal motor nucleus of the vagus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.874271
EGR1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13491_KD_Ncor1_ERP132013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.50675
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-592	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
GSE94768_5_v_2_pofut1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nephrolithiasis_Kidney_GSE10162	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.836049
hsa-miR-4464	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
Perturb_15098_KD_PDHA1_SRP385600	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.78863
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
vacuolar transport	GO Biological Process Annotations 2023	1.0	null
central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08657
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
Cytoplasmic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.359
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD4	ENCODE Transcription Factor Targets	1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
dorsal part of alar p2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72395
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
essential	GeneRIF Biological Term Annotations	1.0	null
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2ES-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0597
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of central motor function	HPO Gene-Disease Associations	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25857
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mode of inheritance	HPO Gene-Disease Associations	1.0	null
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20862
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CG-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30429
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869088
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.4
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920307
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04765
JUND	ENCODE Transcription Factor Targets	1.0	null
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01745
SARS-CoV MA15_Day1-PFU-10^2_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.22234
carotid artery disease	GWASdb SNP-Disease Associations	1.0	1.14463
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.029503
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17673
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965466
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PBX3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ubiquitin-dependent protein catabolic process	GO Biological Process Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GO-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE243199_1_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.98885
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210514
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.128259
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6866_PSMD12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32206
inhibitory	GeneRIF Biological Term Annotations	1.0	null
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pontine gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80722
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17189
CBX3	ENCODE Transcription Factor Targets	1.0	null
HCC1806_BREAST	CCLE Cell Line Proteomics	1.0	3.30908
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24721
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12432
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04975
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898994
r2 part of median raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58575
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31318
abnormal axial skeleton morphology	HPO Gene-Disease Associations	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36535
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11191
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32712
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.09032
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221072
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.78855
superficial stratum of CA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0054
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4763_KO_DLG2_SRP315088	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
cervical adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.11814
Field CA2, stratum pyramidale	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30961
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16582
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.955668
LN319	Achilles Cell Line Gene Essentiality Profiles	1.0	1.48252
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5264-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33475
GATA1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154197_1_v_0_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.270464
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1A	Pathway Commons Protein-Protein Interactions	1.0	null
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.932795
protein targeting	GO Biological Process Annotations 2023	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.803
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
KDM4A	ENCODE Transcription Factor Targets	1.0	null
GSE96991,GSE97117_3_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PK-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
medial part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29751
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.67061
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.891882
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00149
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882867
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31547
membrane fission	GO Biological Process Annotations 2025	1.0	null
H2BK20ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149769_1_v_0_nlrp12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Joint Hyperflexibility	DisGeNET Gene-Phenotype Associations	1.0	null
vestibular nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.826736
CAV1_KO_GDS3551_366_mouse_mouse heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-0226-SM-3DB84	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52926
inferior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.897053
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28873
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.158129
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73566
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-up-Gene_ID_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
CTCFL	ENCODE Transcription Factor Targets	1.0	null
establishment of protein localization to vacuole	GO Biological Process Annotations 2023	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.64259
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052459
HCC1171	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69852
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A6C0-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYRIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10213
escrt i complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.73435
HIPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36986
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00837
ULK-101_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0220045
Parasubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08703
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1944
MYC	ENCODE Transcription Factor Targets	1.0	null
GTEX-QV31-0126-SM-447BP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977149
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08096
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.0684
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918512
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the skeletal system	HPO Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUJ4-0226-SM-4BOP8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950279
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148445
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47527
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471234
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_23_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26012
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967461
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17703
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_937_KD_Smndc1_SRP337256	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.71705
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.60961
COLO684	CCLE Cell Line Gene CNV Profiles	1.0	1.46304
RUNX1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56325
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85464
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131425_2_v_0_arg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46071
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HIV Infection	Reactome Pathways 2024	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15642
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233548_3_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Impaired Cognition	DisGeNET Gene-Disease Associations	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86126
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7489
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56975
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4790-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Membrane binding and targetting of GAG proteins	Reactome Pathways 2014	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 42	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.269
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51858
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60066
QIMR-WIL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60342
macromolecule localization	GO Biological Process Annotations 2015	1.0	null
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35187
epithelium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24514
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39561
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.46473
Synthesis And Processing Of GAG, GAGPOL Polyproteins	Reactome Pathways 2014	1.0	null
Perturb_14151_KD_RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
osteoclasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.30659
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
HIF1A_NULL MUTATION_GDS1648_764_mouse_Hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Anterior olfactory nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53008
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.952967
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0081
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.51388
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28102
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraplegia	DISEASES Curated Gene-Disease Association Evidence Scores 2025	1.0	4.0
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6742
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.07048
RAD21	ENCODE Transcription Factor Targets	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252696
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78387
establishment of protein localization to vacuole	GO Biological Process Annotations 2025	1.0	null
Decreased Vibratory Sense	DisGeNET Gene-Phenotype Associations	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
Centrosome	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.613
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053302
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06901
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924105
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.867403
MRPL28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32832
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.25
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053362
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13922_KO_PPARGC1A_SRP314654	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.87542
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_U87MG_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.513989
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05471
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583255
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548n	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
Adrenocortical carcinoma_ACC_TCGA-OR-A5JZ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.131252
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.843967
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24366
GTEX-QMR6-0011-R2A-SM-32PKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976054
Perturb_17802_KO_ZNF675_SRP305529	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.33733
MCF7_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015678
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
STX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22435
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA6-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hela cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286736
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52543
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	1.0	null
cingulate gyrus, parietal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10027
MYNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22969
RUNX3	ENCODE Transcription Factor Targets	1.0	null
PROCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63766
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.5133
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.69725
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Motor Neuron Disease	DisGeNET Gene-Disease Associations	1.0	null
NCIH1155	CCLE Cell Line Gene Expression Profiles	1.0	1.60568
GTEX-R55G-0326-SM-48FDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894945
anteromedial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28019
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF4	ChEA Transcription Factor Targets	1.0	null
hcc	GeneRIF Biological Term Annotations	1.0	null
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.112
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055717
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.589935
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25378
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588144
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977994
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4517	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11242
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.986482
Perturb_1818_KO_Adam17_SRP394864	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.94217
protein targeting to vacuole	GO Biological Process Annotations 2023	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.931536
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52099
COCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.913164
5232_MRPL49_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533054
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3921_KD_VPS37A/VPS37B/VPS37C_SRP266781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
YKG1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.63705
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30492
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.937956
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96869
6844_PSMA4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39948
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78298
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27929
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ChIP_TCF3_18467660	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160283
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15181
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17472
modification-dependent macromolecule catabolic process	GO Biological Process Annotations 2015	1.0	null
Hypertrichosis	DisGeNET Gene-Disease Associations	1.0	null
KLF4-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06525
BRCA1	ENCODE Transcription Factor Targets	1.0	null
Intracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
UBTF	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23313
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18324
GBGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11724
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A693-06A-13R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171572_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09353
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043183
Impaired Proprioception	DisGeNET Gene-Phenotype Associations	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.29085
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KO-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Diabetic Neuropathy_Sciatic Nerve_GSE11343	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.38973
HS742T	CCLE Cell Line Gene Expression Profiles	1.0	1.53495
AML193	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.10992
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
NACA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21639
heart_6b	HPA Tissue Sample Gene Expression Profiles	1.0	0.987213
white matter of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0684
SNU61	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69423
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-LK-A4NW-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12939
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4343-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31677
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843314
Lung squamous cell carcinoma_LUSC_TCGA-18-3414-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857945
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.69661
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892263
thigh	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.482428
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
mantle zone of CA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00253
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22851
GTEX-O5YV-1126-SM-3LK73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1745
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HuCCT-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
9907_XRCC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.595401
WHSC1	ENCODE Transcription Factor Targets	1.0	null
CNOT3-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.871556
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.09687
multivesicular body assembly	GO Biological Process Annotations 2025	1.0	null
superficial stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28877
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32238
Disease	Reactome Pathways 2024	1.0	null
Perturb_4818_KO_Neil2_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.23128
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55789
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.48246
GTEX-XGQ4-0126-SM-4AT4H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874548
hsa-miR-548an	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.548122
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.506732
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17307
KURAMOCHI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36087
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A3OT-06A-23R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9412_KD_Pcbp1/Platr18_SRP251371	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.73473
GSE151782_3_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Purkinje cell layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05174
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MECOM	ChEA Transcription Factor Targets	1.0	null
ovarian	GeneRIF Biological Term Annotations	1.0	null
missense	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-153	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FGFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2443
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-300	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61803
HIV Infection	Reactome Pathways 2014	1.0	null
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52897
granular layer of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27549
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCA4-20176728-TSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.00884
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7973-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNAJB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3784
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5880-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7390_KO|KD_UPF3A_ERP130415	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.221
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.932691
breast	HPA Tissue Protein Expression Profiles	-1.0	-1.29395
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.5667
abnormality of nervous system physiology	HPO Gene-Disease Associations	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6407-01A-13R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYB561A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55767
superficial stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82107
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A954-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WO-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4464_KO_Bicc1_SRP043577	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.94429
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232