association	dataset	threshold value	standardized value
synthesis	GeneRIF Biological Term Annotations	1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0472
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K02393180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08604
mon1-ccz1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.30067
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06477
BRD-K81997160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20511
H3K4ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Garland cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.733
GSE215086_3_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
cefotaxime-2235	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Adult respiratory distress syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2860-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
MCF7_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146093
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465967
C3A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K56161905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21728
psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.217352
Lung adenocarcinoma_LUAD_TCGA-05-4396-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vacuolar part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.779583
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58955
HS 38.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22421
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67740871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35144
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SARS-CoV-2 Infection	Reactome Pathways 2024	1.0	null
khellin-1922	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rtg2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.607
benperidol-2836	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
late endosome	LOCATE Curated Protein Localization Annotations	1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MON2	Pathway Commons Protein-Protein Interactions	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.613
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5102
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5072
HSPA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09765
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WLS	Pathway Commons Protein-Protein Interactions	1.0	null
SNF8	Pathway Commons Protein-Protein Interactions	1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.214
H3K9me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980174
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPIF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09434
CD47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01416
TE9	CCLE Cell Line Gene CNV Profiles	1.0	1.43152
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.606275
etofenamate-2907	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC11947124-41419_2025_7562_MOESM1_ESM.docx-347-THYN1_THYN1	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.81887
GTEX-OXRL-2626-SM-2I3F1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95872
BRD-K27584103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50631
levomepromazine-3440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
STC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17174
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42699
Perturb_5902_KD_DDX17_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.36286
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129370_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Autophagosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.315
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.182
Prostate adenocarcinoma_PRAD_TCGA-EJ-8468-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
levothyroxine sodium-3249	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
skin_6a	HPA Tissue Sample Gene Expression Profiles	1.0	0.993438
NCIH661	DepMap CRISPR Gene Dependency	1.0	3.12751
CDK3_knockdown_110_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.28635
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910059
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.391523
HEK-293H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.484
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dropropizine-7429	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GALC	Pathway Commons Protein-Protein Interactions	1.0	null
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.85185
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04128
GTEX-Q2AI-1126-SM-48U19	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19018
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.870725
MAPK3	Pathway Commons Protein-Protein Interactions	1.0	null
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
BRD-K46308702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02743
EPHB2	Pathway Commons Protein-Protein Interactions	1.0	null
DMS153	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49657
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61551
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7926
protein complex	GO Cellular Component Annotations 2015	1.0	null
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
embryonic kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.451428
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
WASH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.873
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00378498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3994
SNUC1	CCLE Cell Line Gene CNV Profiles	1.0	2.54675
CRCGN015_MCF10A_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66832
sulfaguanidine-1995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K36me3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PTPN6	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00934921
fusion	GeneRIF Biological Term Annotations	1.0	null
ESCRT IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.983
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TANOUE	DepMap CRISPR Gene Dependency	1.0	2.24583
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.4643
BRD-K77150932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27121
DA-10-HD17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.398244
BRD-K94993773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00875
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DHX36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69454
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25735
CSTB_KO_GDS5090_200_mouse_Cerebellar granule cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3431-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334908
NAPG	Pathway Commons Protein-Protein Interactions	1.0	null
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.946504
hsa-miR-4254	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Lymphatic edema_Skin tissue_GSE4333	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-4.14056
COG5	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2201
genistein-703	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13522
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14621
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
Early endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.877
HDAC1	ENCODE Transcription Factor Targets	1.0	null
skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.365562
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37308
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.68231
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K07009788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01561
BRD-K26163290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52538
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19569
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314133
FC-58-KP35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217654
BRD-K44908880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75721
Embryonic hippocampal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.819
BRD-K35422614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85354
BRD-K12336887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32839
BRD-K82397896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01549
HOXA1_01_110	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59215
asiaticoside-7004	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
XPO4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GOSR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58955712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3242
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233071
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE246053_1_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
eNoSc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.521
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESCRT I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.452
MYOF	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K27911943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1329
Swim bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04041
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12169
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.381332
citiolone-6031	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111385_2_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1772
Coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.346
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lysosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.236
Hsf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.638
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FB-67-PL18_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363018
GTEX-WYJK-1326-SM-3NB2T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833705
BRD-K89377615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18575
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9316
NOTCH1	Pathway Commons Protein-Protein Interactions	1.0	null
Severe acute respiratory syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
Nephrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.684
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ECSIT	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5546-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9305279__F2	PFOCR Pathway Figure Associations 2024	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886242
BRD-K50066702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8081
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GOSR2	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.902335
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K17259076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64521
GTEX-Q2AH-0726-SM-2I3EA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50367
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7047
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1792	DepMap CRISPR Gene Dependency	1.0	2.61015
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50216176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06248
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.78035
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08942
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19278
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phospholipid-translocating ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.006
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.969122
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-1126-SM-48TBU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980103
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235287
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endosome membrane	GO Cellular Component Annotations 2023	1.0	null
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pralidoxime-5383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08329
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZF-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118939_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.989837
SOCS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.561
sirolimus-1162	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K62504352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48292
flumequine-5529	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	2.05939
GTEX-OHPK-0526-SM-2HMJB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967607
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.29541
Chromosome 1q21.1 duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
BLOC1S1	Pathway Commons Protein-Protein Interactions	1.0	null
SUDHL4	CCLE Cell Line Gene Expression Profiles	1.0	1.34983
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.885785
BRD-K32477623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05637
BRD-K29475348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88105
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05298
BRD-K68013677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15195
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01053
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.038991
Brain Lower Grade Glioma_LGG_TCGA-DU-6393-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE199606_2_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CV-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
BRD-K58863194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0772
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.62
Coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.747
PMC4697333__F4	PFOCR Pathway Figure Associations 2024	1.0	null
MCF7_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176253
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DPRX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9449
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04376
Ubp3-Bre5 deubiquitination complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.18
BRD-K30661365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73856
GSE199606_5_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61858
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_16_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4753-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAB2A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.329461
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCM6	CCLE Cell Line Gene Expression Profiles	1.0	1.61314
nordihydroguaiaretic acid-6983	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BE-92-TW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21693
RAB5B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB453	CCLE Cell Line Gene CNV Profiles	1.0	1.52625
PDK1_knockout_265_GSE42187	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.64651
thus	GeneRIF Biological Term Annotations	1.0	null
GTEX-X15G-0526-SM-3NMB7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830079
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DMNB	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71941
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149359_2_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4314	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05429
membrane region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.100967
endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.246407
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.33825
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3843
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Myotonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
LAMTOR3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEC61B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31287
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ITK_knockout_241_GSE12465	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.53242
hippocampus (hippocampal formation)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.889725
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1729
GABP-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4758-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
gibberellic acid-7330	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rpd3L complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
hydroquinine-6263	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22928
MCF7_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164132
BRD-K96604397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01025
rMC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08598
Lung squamous cell carcinoma_LUSC_TCGA-85-8352-01A-31R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prostate	GTEx Tissue Gene Expression Profiles	1.0	1.05184
TSC1	Pathway Commons Protein-Protein Interactions	1.0	null
amprolium-1898	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VJ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15246
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29012
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056409
BRD-K74727418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0048
ATP6V1B2	Pathway Commons Protein-Protein Interactions	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.85471
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RHOG	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K10211218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27655
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984146
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.3227
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14359826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21004
NCI-H2342	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5158
Lung adenocarcinoma_LUAD_TCGA-78-7156-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Keloid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLN5	Pathway Commons Protein-Protein Interactions	1.0	null
COPI-coated Golgi to ER transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.022
NB5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.948365
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RAB9A	Pathway Commons Protein-Protein Interactions	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
Prestwick-857-4980	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SK-N-SH	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08977
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
precentral gyrus, right, bank of the precentral sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.842786
Brain Lower Grade Glioma_LGG_TCGA-HT-A61B-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.26162
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.902415
18160665-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
GTEX-X4LF-0426-SM-3NMB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35564
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196105
cefixime-3247	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_5892_KD_CBX1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.53935
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.47344
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K56283394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77824
AP2M1	Pathway Commons Protein-Protein Interactions	1.0	null
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.835661
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20747
ZNF384	ENCODE Transcription Factor Targets	1.0	null
Mucolipidosis type IV	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
HCC38	CCLE Cell Line Gene Expression Profiles	-1.0	-3.19047
GTEX-S4P3-0426-SM-4AD56	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26854
GTEX-VUSG-0726-SM-3GIK1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858559
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-WY-A85D-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K93032100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13578
trimethoprim-2345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06645
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06475437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79175
Dynactin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.602
PMC10714175-mmc2.xlsx-KD_Gene_list-Supplemental_Table_3_FAM13B_knockdown_mediated_changes_in_gene_expression_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170171
GTEX-U8XE-1426-SM-3DB8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05827
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42523
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cryptococcosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
BRD-K04454173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11094
RHOT1	Pathway Commons Protein-Protein Interactions	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82284644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89883
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999262
ACT-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.168
BRD-K44536345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52149
GSE198165,GSE198166_5_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Centriolar satellite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.57
ARFRP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.66047
azathioprine-338	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pathophysiology	GeneRIF Biological Term Annotations	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Congenital vertical talus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.88244
DGCR6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03612
BRD-K07313741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05343
SNX7	Pathway Commons Protein-Protein Interactions	1.0	null
KNTC1	Pathway Commons Protein-Protein Interactions	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
osteoclasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.433
hops complex	GO Cellular Component Annotations 2015	1.0	null
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.74066
STXBP2	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.969122
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.587254
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
pyramidal cells of rostral CA4	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.966819
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4854
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
high-affinity iron permease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.038
PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_HNSCC_HNSCC_DDP_NOT_DDR_Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
nordihydroguaiaretic acid-415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Membrane coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.823
Perturb_5992_KD_ZNF512_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.31144
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8951
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.944498
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.912
fulvestrant-367	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE114232_10_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.977374
ARAP3	Pathway Commons Protein-Protein Interactions	1.0	null
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.964173
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYK_knockdown_279_GDS3609	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.89141
GTEX-PSDG-0726-SM-2I5FN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827741
BRD-K02625776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11369
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hydralazine-3621	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K77797589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52717
Apicoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.819
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7LX-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29432
BRD-K90408478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34253
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB20	Pathway Commons Protein-Protein Interactions	1.0	null
9328_TRRAP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07192
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cellular	GeneRIF Biological Term Annotations	1.0	null
ERBB2IP	Pathway Commons Protein-Protein Interactions	1.0	null
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	1.0	0.871148
JAK1	Pathway Commons Protein-Protein Interactions	1.0	null
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060231
lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
A549_Cediranib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00933909
DOK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21593
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
prednisolone-265	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
adiphenine-1709	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAB1B	Pathway Commons Protein-Protein Interactions	1.0	null
SARS-CoV Infections	Reactome Pathways 2024	1.0	null
Perturb_6572_KO_Gls_SRP338093	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.35377
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03282
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VG-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68125
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44961
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OCT4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80L-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TXLNA	Pathway Commons Protein-Protein Interactions	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.13646
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.41692
(-)-isoprenaline-6833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6143-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76985713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08746
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.759177
PDS5A	Pathway Commons Protein-Protein Interactions	1.0	null
KM12	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97615
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.39733
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HAL-01	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.99067
nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.233101
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU16	DepMap CRISPR Gene Dependency	1.0	2.28787
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DL-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K06220918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30482
BRD-K93391478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30115
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.434
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
estradiol-373	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MET_knockout_263_GSE8747	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.81351
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56233
GTEX-WFON-0126-SM-4LVM9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50473
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTPase activator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.431
CA-73-BW50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254467
establishment of protein localization	GO Biological Process Annotations 2015	1.0	null
PMC6464042__F6	PFOCR Pathway Figure Associations 2023	1.0	null
naftifine-7032	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
vacuolar membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.77326
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33211
IRF1	ENCODE Transcription Factor Targets	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
Kaposi's sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WH7G-2326-SM-3NMBC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11761
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.72838
TEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7307
COPI vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.206
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03244
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2779
lomefloxacin-3620	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.885835
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.886165
BRD-K57096799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27389
Early endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.327
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.47748
CDK2	Pathway Commons Protein-Protein Interactions	1.0	null
pentetrazol-5508	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K75821161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28009
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946387
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.832818
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.937837
vacuolar HOPS complex	GO Cellular Component Annotations 2025	1.0	null
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265605
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148669
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.951412
SW1990	DepMap CRISPR Gene Dependency	1.0	2.0883
piccolo-bassoon transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.682
propafenone-2871	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54756
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05998
SETD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15579
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
merkel cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.908553
ILK	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33705415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22455
WA-03-IF37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488996
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32506
BRD-K45677957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67677
BRD-K41853443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80228
BRD-K00620786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16513
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313266
GE-77-FY84_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303618
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.971099
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257138
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91015
BACH1-22875853-HELA-AND-SCP4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.495
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE244072_4_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE252857_2_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40583
MEL-JUSO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.889
BB-20-UU03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.788522
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
embryoday6.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.32701
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.27383
SP1	ENCODE Transcription Factor Targets	1.0	null
COLO678	CCLE Cell Line Gene Expression Profiles	1.0	1.74864
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-7332-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.03092
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNPEP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25883
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.862216
BRD-K97537859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3771
BRD-K69248736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10118
Pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
EZH2	ENCODE Transcription Factor Targets	1.0	null
SMC4	Pathway Commons Protein-Protein Interactions	1.0	null
RIOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59318
BRD-K09108485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24062
BRD-K17979415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71282
ARFGEF1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1742_COG3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11538
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.983799
regulation of SNARE complex assembly	GO Biological Process Annotations 2023	1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.716939
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044771
PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0198
GTEX-U4B1-1426-SM-4DXTX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09653
clorgiline-1604	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE187006_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.484946
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09984
K562_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148278
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58627
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8104-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
xylometazoline-7020	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NO10	DepMap CRISPR Gene Dependency	1.0	2.37869
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.863164
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
sulindac-1693	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NFK9-0226-SM-2HMKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1024
Vacuolar lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.837
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SC-19220-7095	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tbc1d15rab7gap	GeneRIF Biological Term Annotations	1.0	null
Endomembrane system	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.5
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87168
EC-67-PV87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270254
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-2326-SM-3DB96	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873097
FLI1	ENCODE Transcription Factor Targets	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50138
SELENBP1	Pathway Commons Protein-Protein Interactions	1.0	null
COPII-coated ER to Golgi transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.613
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27634
Lung adenocarcinoma_LUAD_TCGA-78-7633-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.474
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K14070721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42057
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00406
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37986
Gaucher's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
Phagocytic cup	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.667
BRD-K92981306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29565
capable	GeneRIF Biological Term Annotations	1.0	null
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28964
Cardiovascular Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
thalidomide-606	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Clathrin coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.739
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE109140_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.96448
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62562
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.47938
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F0-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETS1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
OMC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4477
GSE135514_8_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.865932
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915422
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.681123
GSE160246_9_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AP3M1	Pathway Commons Protein-Protein Interactions	1.0	null
alimemazine-7235	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.84935
GTEX-QEG5-0826-SM-2I5GF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840475
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13152
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
nitrendipine-5405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31287
CRCGN014_HEPG2_3H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23395
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854906
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39454
mRNA_TCF3_20139965	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K15019832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11951
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
VEGFA VEGFR2 signaling	WikiPathways Pathways 2024	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.924673
S-isopropylisothiourea	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18668
ATP6V1D	Pathway Commons Protein-Protein Interactions	1.0	null
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PI-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
PMC4905481-oncotarget-07-11397-s003.xlsx-Pinin_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1869	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44958
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01255
lynestrenol-2037	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1784
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HeLa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.974
Kidney Chromophobe_KICH_TCGA-KL-8330-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849912
CLCN7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFJO-0926-SM-4LVM2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931161
APPL2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-320a	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05091
ZYX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36467
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49137
18381933-SuppTableS4	GeneSigDB Published Gene Signatures	1.0	null
K562_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017112
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SH3BP1	Pathway Commons Protein-Protein Interactions	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.951769
BRD-K41717398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50958
GTEX-Q2AG-0826-SM-2HMKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29252
BRD-K91998226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27956
PMC4051124-1471-2164-15-256-S16.XLSX-WES_IPD-RBCK1_2-Target_RBCK1	Rummagene Transcription Factor Associations 2026	1.0	null
Cerebellum	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.09487
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6869-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
deep layers of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.956154
GTEX-T5JW-0126-SM-4DM6K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937894
Diabetes Mellitus, Type 2	HuGE Navigator Gene-Phenotype Associations	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
skin_5f	HPA Tissue Sample Gene Expression Profiles	1.0	1.88857
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S4Z8-0226-SM-4AD5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847542
BRD-A63704386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14911
Hermansky-Pudlak syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C1-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223008_7_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Golgi transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.27
A549_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106525
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6348-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13175
ventral posterior inferior nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.849451
endocytic recycling	GO Biological Process Annotations 2023	1.0	null
EXOC7	Pathway Commons Protein-Protein Interactions	1.0	null
SON_KD_GDS4448_35_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CDK1	Pathway Commons Protein-Protein Interactions	1.0	null
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
CCT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91454
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23247
WSUNHL	DepMap CRISPR Gene Dependency	1.0	3.04339
RMUGS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3711
outer SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.881598
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TE-12	GDSC Cell Line Gene Expression Profiles	1.0	3.51725
UMUC1	DepMap CRISPR Gene Dependency	1.0	2.16668
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UterusCorpus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.28059
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195713_0_v_1_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NSF	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58809
ADAMTS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47241
ARL2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72026
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.65062
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13769
Vacuolar HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.818
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215086_3_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
eticlopride-5695	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PX3G-2026-SM-48U1H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20249
ROCK1	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chlorpromazine-419	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CDC42SE2	Pathway Commons Protein-Protein Interactions	1.0	null
ANXA9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3862_HNRNPDL_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.55853
GTEX-T6MN-0626-SM-32PM9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993519
TAP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.086376
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2185	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.33965
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FS-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32605
Lung squamous cell carcinoma_LUSC_TCGA-85-7844-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	1.27218
BRD-K91897530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28587
bergenin-3467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
THUMPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06178
XPOT	Pathway Commons Protein-Protein Interactions	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-6207-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.317315
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.870725
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TSE9-0326-SM-3DB82	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9705
benserazide-641	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A101D	GDSC Cell Line Gene Expression Profiles	1.0	1.6099
ACAP2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-216b	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
AP-5 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.586
Body wall muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.977
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30862
NOTCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3129
Lung adenocarcinoma_LUAD_TCGA-97-A4M2-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.59826
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAOK1	Pathway Commons Protein-Protein Interactions	1.0	null
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056761
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
verob4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.099
VASP	Pathway Commons Protein-Protein Interactions	1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPMI8226	DepMap CRISPR Gene Dependency	1.0	2.29019
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATPase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
SPI1	ENCODE Transcription Factor Targets	1.0	null
retinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.294413
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.29477
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19985
Lung adenocarcinoma_LUAD_TCGA-86-8278-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603603
PMC5813884__F2	PFOCR Pathway Figure Associations 2023	1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.993012
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.79375
melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.396087
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
precuneus, right, inferior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.910597
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21646
CC-00-ZO24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.738834
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lytic vacuole membrane	GO Cellular Component Annotations 2023	1.0	null
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.218
GTEX-PWCY-0226-SM-48TD8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895596
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plant-type vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.290678
Perturb_5917_KD_HNRNPL_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.46175
VAPA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	1.0	null
TRAPPC5	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
H3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01612
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
lateral parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21743
GARP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.701
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_2_ZZZ3_occupied_genes-ATAC1_bound_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
Charcot-Marie-Tooth disease type 2B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
GRTP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XBED-2226-SM-47JYQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1941
HUNS1	DepMap CRISPR Gene Dependency	1.0	3.48036
BRD-K12397820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41544
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.446038
PXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9349
ACTL6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30776
GSE130396_8_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
T98G	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96225
hsa-miR-4268	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
PMC10459248__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857052
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.963008
GTEX-SN8G-0126-SM-32PLI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25974
GSE199606_5_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7891
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CW9019	DepMap CRISPR Gene Dependency	1.0	3.44592
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.9526
CDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01527
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02273
PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-HVC_612_gene_expression_ratio_in_ZF_and_OF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8082-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Schizophrenia	CTD Gene-Disease Associations	1.0	2.88009
COG3	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5870-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60737
NCIH1581	DepMap CRISPR Gene Dependency	1.0	2.88809
GTEX-OIZH-0926-SM-48TBR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876827
BRD-K07551625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01133
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00273
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.80897
phosphorylation	GeneRIF Biological Term Annotations	1.0	null
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NU-1025-608	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.58108
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13139
skin	HPA Tissue Gene Expression Profiles	1.0	1.31953
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34343777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12262
GSE239844_1_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XQ8I-1726-SM-4BOQB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2109
GSE223008_0_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
berberine-6791	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lysosomal	GeneRIF Biological Term Annotations	1.0	null
BRD-K22063616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81992
hsa-miR-548an	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.81633
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-4679-01B-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFPL1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944126
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSB-1626-SM-3LK6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07264
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4986
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.964257
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.717378
OE33	GDSC Cell Line Gene Expression Profiles	-1.0	-1.90175
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
FOXS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29944
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VAPB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051081
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEC61A1	Pathway Commons Protein-Protein Interactions	1.0	null
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KIAA1033	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCPAP	DepMap CRISPR Gene Dependency	1.0	2.67145
pridinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40044
CHMP6	Pathway Commons Protein-Protein Interactions	1.0	null
TMED1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954797
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.952563
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4R8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
carbinoxamine-3466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9254
SEPT9	Pathway Commons Protein-Protein Interactions	1.0	null
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JJN3	DepMap CRISPR Gene Dependency	1.0	2.83884
OVMANA	DepMap CRISPR Gene Dependency	1.0	2.20315
C-33A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.612571
Lung adenocarcinoma_LUAD_TCGA-78-7220-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.837741
BRD-K93153656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50998
hsa-miR-320e	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
organelle part	GO Cellular Component Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-FX-A3TO-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.94087
fungal-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.635
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228497
ZNF438	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11173
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YS-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_ATF1-gene_ATF1	Rummagene Transcription Factor Associations 2026	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3652	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
brompheniramine-3271	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6247
dihydroergotamine-2244	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996157
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.47218
Liver epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
GTEX-QV44-0826-SM-2S1RG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17094
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58224
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
tetramisole-2849	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CYB5R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39232
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872848
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPT1	Pathway Commons Protein-Protein Interactions	1.0	null
NALM1	CCLE Cell Line Gene Expression Profiles	1.0	1.51555
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4446
BRD-K30013451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68814
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346688
KLC4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
CALM1	Pathway Commons Protein-Protein Interactions	1.0	null
EARP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.086
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06439
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
Perturb_14236_KO_Tet2_SRP237910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.78927
neomycin-7221	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.953051
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22445
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5948_KD_PRRX2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.50875
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00435
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.171
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09893
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13522
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.311
GTEX-X3Y1-0626-SM-3P5YS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961254
mitochondrion-derived vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.572
smoothmuscle_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.16239
BRD-K24035524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06288
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63052
molecular	GeneRIF Biological Term Annotations	1.0	null
MCF7_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127096
VPS35	Pathway Commons Protein-Protein Interactions	1.0	null
GOLPH3L	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11462941-CAS-115-2947-s001.pdf-158-IRF7_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
MZ in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26329
trazodone-7410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5688
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53431
BRD-K78904317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05346
zimeldine-5670	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE225869_1_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
PIP4K2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33425
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
endolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.559285
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49446
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
late endosome to lysosome transport	GO Biological Process Annotations 2023	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305869
HCV JFH1_120Hour-Huh7_5_1_None_GSE29889	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.65463
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71563254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05005
minocycline-7436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21253219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15672
BRD-K83895653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00606
HEPG2	DepMap CRISPR Gene Dependency	1.0	2.27387
PMC5031867-mmc2.xlsx-RYTTCCTG_V_ETS2_B-PROBE_ETS2	Rummagene Transcription Factor Associations 2026	1.0	null
tacrolimus-169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
shsy5y	HPA Cell Line Gene Expression Profiles	1.0	0.845627
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24436
SPC25	Pathway Commons Protein-Protein Interactions	1.0	null
Pollen tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.829
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944949
SMC1A	Pathway Commons Protein-Protein Interactions	1.0	null
TRAPP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.858
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBC1D1	Pathway Commons Protein-Protein Interactions	1.0	null
GOLT1B	Pathway Commons Protein-Protein Interactions	1.0	null
valproic acid-458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T8EM-0226-SM-3DB7C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844279
TGFBRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7933708-mmc2.xlsx-DNMT-target_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.3813
PMC3568013-1471-2105-13-128-S5.xls-NME2-Unnamed_1_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202017,GSE202018_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K85475457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18698
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
HB-69-CT62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490558
SDF4	Pathway Commons Protein-Protein Interactions	1.0	null
BB-74-RX30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346643
acemetacin-7442	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01388
fursultiamine-4975	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A47166394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80037
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vesicle-mediated transport to the plasma membrane	GO Biological Process Annotations 2023	1.0	null
CCLFUPGI0005T	DepMap CRISPR Gene Dependency	1.0	2.59047
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WR-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.189
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.07
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K51697315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30012
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.884418
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GNA11	Pathway Commons Protein-Protein Interactions	1.0	null
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.39464
supramammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15858
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12447
Cervical adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.974
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40887375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20242
syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.17896
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.93353
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48741
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZDHHC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16543
fludrocortisone-281	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.632
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08583
paracetamol-5384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045388
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNX5	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.24162
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.502693
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
gm03123	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
RPMI 2650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BF-69-DN58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239282
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21515
GSE226249_5_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7861
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEPT2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZM-1526-SM-3DB9D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7352
Early phagosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.751
TCCSUP	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.78943
copper sulfate-438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
Multivesicular body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.825
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5411
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38511
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Autophagosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.416
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IE-A4EI-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Seh1-associated complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.972
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15122
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13877
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193726
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lytic vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.632878
L-540	GDSC Cell Line Gene Expression Profiles	-1.0	-2.10815
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-0126-SM-2TF57	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07467
hsa-miR-3129-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Aorta	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.18957
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RKN	CCLE Cell Line Gene CNV Profiles	1.0	1.39499
GTEX-XK95-0426-SM-4AT4R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890751
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460379
SKGT2	DepMap CRISPR Gene Dependency	1.0	2.78142
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.398
GTEX-XYKS-1526-SM-4BRUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827355
GSE139455_0_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153601
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.31187
BRD-K65829768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40543
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0179
OSBP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K15123815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.532
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ARCN1	Pathway Commons Protein-Protein Interactions	1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17935
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.866259
GTEX-WRHU-1026-SM-4E3ID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928422
GTEX-RWS6-0626-SM-2XCAS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92733
zoxazolamine-1270	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FUT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22468
rosiglitazone-1013	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
maintaining	GeneRIF Biological Term Annotations	1.0	null
Perturb_5941_KD_PHB_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.019
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10623
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESCRT III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.411
RRAS2	Pathway Commons Protein-Protein Interactions	1.0	null
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.67
piroxicam-7445	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
lytic vacuole	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K79885457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0743
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Septin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.849
NAGLU	Pathway Commons Protein-Protein Interactions	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21812
BRD-K83297764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40184
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.7495
BRD-K88925664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02083
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09926
SARS-dORF6_60Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.76066
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3037
TYKNU	DepMap CRISPR Gene Dependency	1.0	2.81662
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76948
Cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25543
Golgi apparatus subcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.022
GSE182680,GSE182683_0_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF630	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08209
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
GBA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XOTO-2826-SM-4B65I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08271
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19005
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.034141
rosiglitazone-369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13321
hela	HPA Cell Line Gene Expression Profiles	1.0	1.07203
BRD-K46376359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.95057
idoxuridine-1980	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Middle East respiratory syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23108
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAP2K3	Pathway Commons Protein-Protein Interactions	1.0	null
oxantel-2632	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cetirizine-2829	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HINT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25953
BRD-K31348453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11141
CE-15-YU05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246912
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SKI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22997
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210137
HL60	CCLE Cell Line Gene Expression Profiles	1.0	1.40371
BRD-K57972271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2231
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
Vici syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.284
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.260202
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RK-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K92955882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07062
cd8 cells	HPM Cell Type and Tissue Protein Expression Profiles	1.0	0.850818
BRD-K51608228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03201
Fetal Brain Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.24604
59M	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74873
celecoxib-206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VPS29	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasm	GeneRIF Biological Term Annotations	1.0	null
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49681465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01283
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23749
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pons	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.829274
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.851506
BRD-K03440991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.005
endosome	LOCATE Curated Protein Localization Annotations	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.85049
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Choreaacanthocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
H3K36me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LY-294002-6976	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondria-associated endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.214
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4818
Necrosis	CTD Gene-Disease Associations	1.0	1.05163
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
monorden-325	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FAM129B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC23	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K54364215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15591
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF-16-IB77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584832
MCM2	Pathway Commons Protein-Protein Interactions	1.0	null
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299097
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861746
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.55236
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03594
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
DYRK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00416
TE4	CCLE Cell Line Gene CNV Profiles	1.0	1.82935
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11133
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167062
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTPN1	Pathway Commons Protein-Protein Interactions	1.0	null
Niemann-Pick disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.933248
yohimbine-2755	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clozapine-5630	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51141
SH3GLB2	Pathway Commons Protein-Protein Interactions	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE146687_2_v_1_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119786
TAOK3	Pathway Commons Protein-Protein Interactions	1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.72731
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.979701
NCSTN	Pathway Commons Protein-Protein Interactions	1.0	null
Sphingolipidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.39885
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0126-SM-33HB3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04178
GTEX-R55G-2526-SM-2TC6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00733
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.80603
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.902
SEPT8	Pathway Commons Protein-Protein Interactions	1.0	null
FU-OV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K38118311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46895
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971322
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8173
GTEX-T8EM-1826-SM-4DM7F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92966
BRD-K07525144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22921
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Trolox C-2883	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959036
Nucleoplasmic THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.55
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18704
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
genistein-268	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K14ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5823
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXP1_FOXP1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.844811
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HX-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93941597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68755
BRD-K59491389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.84018
sotalol-2918	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
GSE220693_1_v_0_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23311
H2BK12ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MBLAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2728
HNT-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08504
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33737
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19108
dirithromycin-7446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CSTB_KO_GSE47516_678_mouse_mouse cerebellum at P30	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8953
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03701
NCIH226	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63734
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EPB41L2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A84941884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51054
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02729
methanthelinium bromide-6254	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
macromolecule localization	GO Biological Process Annotations 2015	1.0	null
BRD-K05335635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18633
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52786
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.954879
Calu-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.352
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21757
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
endocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.122666
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902145
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EF-62-IO23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315628
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14162
SMAD2	Pathway Commons Protein-Protein Interactions	1.0	null
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.09878
etanidazole-6072	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
vacuolar part	GO Cellular Component Annotations 2015	1.0	null
SNU201	CCLE Cell Line Gene Expression Profiles	1.0	1.55171
PMC8166871__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Influenza	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936159
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963016
RHEB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-RNF181_KD_significant-Unnamed_23_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SNU738	CCLE Cell Line Gene CNV Profiles	1.0	2.07045
GTEX-RU72-0926-SM-2TF6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08083
furazolidone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.92598
STX17	Pathway Commons Protein-Protein Interactions	1.0	null
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.657679
KE-41-JG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.412427
K562_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151282
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163657
BRD-K18268126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82583
GSE210718_1_v_0_shmt2_human	RummaGEO Gene Perturbation Signatures	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LAMP2	Pathway Commons Protein-Protein Interactions	1.0	null
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.70122
BRD-K43000271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24969
Ets	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264911
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
only	GeneRIF Biological Term Annotations	1.0	null
GTEX-SNMC-0926-SM-4DM5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35709
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23186
ZNF207	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70304
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45342
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.6052
SLR24	DepMap CRISPR Gene Dependency	1.0	2.22301
BRD-K01182779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18375
LS1034	CCLE Cell Line Gene CNV Profiles	1.0	1.35857
KARPAS422	DepMap CRISPR Gene Dependency	1.0	2.44669
BRD-K76215709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22525
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.904972
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.960538
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIF5B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE195582_2_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1001
MAZ	ENCODE Transcription Factor Targets	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	Reactome Pathways 2024	1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.391793
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29955
UO31	CCLE Cell Line Gene CNV Profiles	-1.0	-2.43921
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02957
BRD-K77177732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23156
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AP3B1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K30921693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56166
BRD-K90962922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77471
ocular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.290462
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Helam	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.168
NKIRAS2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFATC1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
autophagosome-lysosome fusion	GO Biological Process Annotations 2023	1.0	null
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A8YF-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
late endosome to lysosome transport	GO Biological Process Annotations 2025	1.0	null
Lysosomal HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.52
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.862216
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PF-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05203
PTP4A1	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861701
GTEX-NL4W-0011-R2a-SM-2I5GV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834336
MOSPD2	Pathway Commons Protein-Protein Interactions	1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215611
localizing	GeneRIF Biological Term Annotations	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.57596
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-125a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BRD-K35520972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04913
oligomycin-442	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-2226-SM-46MW4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59476
PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-RA_812_genes_expression_ratio_in_ZF_and_OF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
HAX1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216757_4_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31724
MCF7_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152524
arachidonyltrifluoromethane-327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984356
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6394
BRD-K96459367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87612
LY-294002-1157	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E1-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.12494
VPS28	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27284
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17695
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SNX15	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.15894
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235854
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07905
SCFD2	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-4938-01B-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05845
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48945
meticrane-1792	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7241
GSE239844_4_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151353
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A83X-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SNARE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.659
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
acts	GeneRIF Biological Term Annotations	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45583
smad2dependent	GeneRIF Biological Term Annotations	1.0	null
K562_Veliparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220617
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41565
BRD-K17675814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22247
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63W-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Encysting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BD-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-U8T8-0126-SM-3DB94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15681
GTEX-QLQW-0126-SM-447BK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64894
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.59138
BRD-K94082609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41397
Microbody membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.962
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21711
GTEX-PLZ6-1126-SM-3P5ZR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75754
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.246
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49037
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03191
hsa-miR-627	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K81660107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67864
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872208
PCTP	Pathway Commons Protein-Protein Interactions	1.0	null
Late endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.735
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
TLN1	Pathway Commons Protein-Protein Interactions	1.0	null
TBC1D9B	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.86191
TM31	CCLE Cell Line Gene CNV Profiles	1.0	1.96018
Early phagosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.294
Prostate adenocarcinoma_PRAD_TCGA-HC-7075-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.09826
PLEK2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
retinal cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.294413
GTEX-XPVG-2626-SM-4B669	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62689
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.912438
PRKAG1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.43538
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.905001
RAJI	DepMap CRISPR Gene Dependency	1.0	2.03548
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
wortmannin-506	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prestwick-559-7462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lysosomal HOPS complex	GO Cellular Component Annotations 2025	1.0	null
plant-type vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.265
amiloride-1970	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
iPS-18 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.936052
GSE223008_6_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Septin ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.946
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08137
BRD-K41829399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61251
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.306
GSE190864,GSE190907_1_v_0_cacybp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Basolateral cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHT101	DepMap CRISPR Gene Dependency	1.0	3.27247
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03470412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29407
trimetazidine-2876	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anaplasmosis_Leukemic Cell_GSE2600	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.37709
BLOC1S2	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
NFIC	ENCODE Transcription Factor Targets	1.0	null
pregnenolone-2856	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARHGAP17	Pathway Commons Protein-Protein Interactions	1.0	null
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.63349
TOV112D	DepMap CRISPR Gene Dependency	1.0	3.50276
benzamil-3635	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ERBB3	Pathway Commons Protein-Protein Interactions	1.0	null
RAC1	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4620-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_14237_KO_Tet1_SRP237910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.79392
MERO83	DepMap CRISPR Gene Dependency	1.0	2.54563
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0571
GBF1	Pathway Commons Protein-Protein Interactions	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54D-01A-21R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fat body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.28
Lung adenocarcinoma_LUAD_TCGA-86-7953-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
lung_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.50467
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Multivesicular body membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mc116	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2025	1.0	null
Lytic vacuole membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE231720,GSE231724_3_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.329
HOPS complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MTOR	Pathway Commons Protein-Protein Interactions	1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54842
BRD-K60862683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37547
S2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.319
BRD-K30865566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14005
BRD-K42799692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24783
BRD-K50575036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25223
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-QDVJ-1126-SM-48U1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14893
bendroflumethiazide-3415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NOMO-1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
u26684	HPA Cell Line Gene Expression Profiles	1.0	1.39756
Rab-protein geranylgeranyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.935
skin carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.498085
H3K36me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39168
CRCGN016_MCF10A.TP53.M_24H:O17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07466
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
LSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39629
astrocytes	BioGPS Cell Line Gene Expression Profiles	1.0	0.937354
MOB1B	Pathway Commons Protein-Protein Interactions	1.0	null
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.928835
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0593
vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.843318
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_3_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE202134_0_v_1_rbm39_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.963
DF-53-QT23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257475
hsa-miR-4519	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
pyramidal layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.859105
Hyperactive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0143
MESSA	CCLE Cell Line Gene Expression Profiles	1.0	1.83457
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
altered	GeneRIF Biological Term Annotations	1.0	null
BRD-K13803936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15608
Ocular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03019
SDAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28705
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20215
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.874137
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.947689
BRD-K51320582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93559
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.85018
AKT1_knockout_211_GSE39699	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.23802
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DYNC1LI1	Pathway Commons Protein-Protein Interactions	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.26027
PDGF_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Activin responsive factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.561
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967587
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73768
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50934
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-2026-SM-3NB1M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12286
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
guanyl-nucleotide exchange factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.132
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13824
GSE142684_2_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44665
H3K36me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C17orf107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28568
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04467
BRD-K24614157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52599
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.932638
AC-28-RT00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.709401
Uterine cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD1	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044684
Lung squamous cell carcinoma_LUSC_TCGA-LA-A446-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFATC1	ENCODE Transcription Factor Targets	1.0	null
HCC366	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02873
ambroxol-1623	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
tolnaftate-1919	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896887
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343266
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-4747-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
hops complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.75275
BRD-K46428124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17959
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39706
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70008
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37945
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKNFI	CCLE Cell Line Gene Expression Profiles	1.0	1.54265
ATP6V1E1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-1.35182
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Peeling skin syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.53725
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
normal	GeneRIF Biological Term Annotations	1.0	null
Vero cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.613
TNFAIP8	Pathway Commons Protein-Protein Interactions	1.0	null
Sensory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301748
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527546
SYK	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K58756877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13184
CLTA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K59263278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13934
GTEX-S7SE-0726-SM-2XCD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10658
SEC22B	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NF2	Pathway Commons Protein-Protein Interactions	1.0	null
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19L-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382326
NCI-H157 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.736
levetiracetam_rattus norvegicus_gpl1355_brainstem_gds1864	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156096
KDM5A	ENCODE Transcription Factor Targets	1.0	null
COPI-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.203
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.341
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76054
GTEX-PLZ6-0226-SM-3P61I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12952
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07357
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59839
BRD-K29039402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24038
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.979701
GSE214842_0_v_1_atf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4736
hsa-miR-4430	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052872
BRD-K84551755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1098
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.738987
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LIN7C	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4306_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.32554
doxylamine-4819	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07667635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06925
GTEX-S341-0226-SM-2XCAX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856044
GABPA-29892750-EML-MOUSE-BONEMARROW	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ferroxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.553
GM2A	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
lysosomes	GeneRIF Biological Term Annotations	1.0	null
HUH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95518
TO14	DepMap CRISPR Gene Dependency	1.0	2.35769
BRD-K78169765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88634
JSC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77809
GTEX-P44H-0226-SM-2XCEU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14097
torc1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.233101
CTSA	Pathway Commons Protein-Protein Interactions	1.0	null
Vacuolar HOPS complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26043
CUX1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBJ-2026-SM-3NB1R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19998
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
AG-028671-6587	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DTNBP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CASK	Pathway Commons Protein-Protein Interactions	1.0	null
apomorphine-2005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE130383_1_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neuroacanthocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
TUSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41203
BRD-K43680691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09027
KISS1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38151
Respiratory failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
PRIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23226
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46559
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.07854
ebselen-5778	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ3S-1526-SM-4BOOC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00008
A549_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147957
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH660	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69148
Clathrin adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.259
TSG101	Pathway Commons Protein-Protein Interactions	1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R7-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GADD45GIP1	Pathway Commons Protein-Protein Interactions	1.0	null
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64509887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05277
Acute Myeloid Leukemia_LAML_TCGA-AB-2964-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6882-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-RVPU-2326-SM-2TF6R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840856
Phagophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.826
Bacterial Infection_Peripheral blood mononuclear cell_GSE3026	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.65252
RIC8A	Pathway Commons Protein-Protein Interactions	1.0	null
amitriptyline-167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EXOC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K79730625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09516
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-XGQ4-0126-SM-4AT4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38192
SNX4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60695
GTEX-NFK9-1026-SM-2HMK1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31375
GTEX-REY6-2126-SM-48FD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03564
K562_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015303
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.907303
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.69975
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
EXOC2	Pathway Commons Protein-Protein Interactions	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MAPKAPK2	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PX3G-3026-SM-48TZR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85035
Lysosomal lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.568
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.839506
20368555-TS-1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K89194869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91343
H3K9me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chlorpromazine-6936	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K92344227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01594
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415574
lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.585942
SAP30	ENCODE Transcription Factor Targets	1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.68697
TBL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12233
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842482
SETDB1	ENCODE Transcription Factor Targets	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56485
GTEX-UPIC-1626-SM-4IHKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16212
PRKAB1	Pathway Commons Protein-Protein Interactions	1.0	null
responses	GeneRIF Biological Term Annotations	1.0	null
NELFA-20434984-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07627
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5972_KD_TARDBP_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.83288
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184992
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97761115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44362
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1285	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199606_3_v_0_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EHD1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81468
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7M4-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
retinoblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.294413
superior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18749
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19186
endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.640573
PMC9534503__F6	PFOCR Pathway Figure Associations 2024	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04562748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12581
fluocinonide-3414	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EBC1	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284509
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K92372829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49086
GTEX-XUW1-0926-SM-4BONX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71697
hsa-miR-122	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K56783915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82475
Brain Lower Grade Glioma_LGG_TCGA-FG-6692-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26672
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.70656
BRAF_druginhibition_38_GDS5085	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.89936
SPI1	ChEA Transcription Factor Targets	1.0	null
Claw	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
GTEX-QLQ7-1626-SM-2S1R8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35639
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172499
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.993012
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A84U-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61375
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DCA_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K97298761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10517
GSE169152_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68162101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64817
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3903
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4685-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
BRD-K08618283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64868
budesonide-5431	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30673
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
VPS25	Pathway Commons Protein-Protein Interactions	1.0	null
TAGLN2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-320c	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
COPB1	Pathway Commons Protein-Protein Interactions	1.0	null
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.46303
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
hsa-miR-766	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12048
GSK3B	Pathway Commons Protein-Protein Interactions	1.0	null
ATP6V1A	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.73304
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04912
PICK1	Pathway Commons Protein-Protein Interactions	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21692
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86192
large	GeneRIF Biological Term Annotations	1.0	null
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4854
RGL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46859
er-mitochondrion membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.53896
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.349105
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
BRD-K37276417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53766
ARL8B	Pathway Commons Protein-Protein Interactions	1.0	null
NSC-625987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15622
BRD-K21753319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1084
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13978
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051144
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.263
anabasine-6074	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10889
vacuolar HOPS complex	GO Cellular Component Annotations 2023	1.0	null
spiradoline-3901	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22673
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9242
VPS45	Pathway Commons Protein-Protein Interactions	1.0	null
UNC93B1	Pathway Commons Protein-Protein Interactions	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.5944
ARC syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.069
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thioridazine-1905	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957265
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23806
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055912
Peeling skin syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
CTH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05727
BAY-11-7085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27148
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18122
RAP1GDS1	Pathway Commons Protein-Protein Interactions	1.0	null
Pigment granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.401
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859251
GSE151829,GSE151831_3_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95941120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0066
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47775
clofazimine-3239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889926
Perturb_5936_KD_MYEF2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.98808
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1746
Hypodermal seam cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
MCF7_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163906
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36812047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09752
SR786	CCLE Cell Line Gene Expression Profiles	1.0	1.43203
lobelanidine-5500	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VAMP3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4803	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
GP1BA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40299
SCAMP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879376
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
reticular nucleus of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.96946
hsa-miR-4676-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
ARHGEF10L	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0328
Prestwick-689-7173	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K81642886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05313
ABCG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49307
CHEK1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K17610834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16969
DU145	CCLE Cell Line Gene Expression Profiles	-1.0	-3.0303
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KMS34	DepMap CRISPR Gene Dependency	1.0	2.48586
inner CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844007
todralazine-5512	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.961
MDAMB436	DepMap CRISPR Gene Dependency	1.0	2.87607
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02217
BRD-K03715233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42145
FAM170A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23815
tubocurarine chloride-1738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_8483_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.85808
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT6	Pathway Commons Protein-Protein Interactions	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.671
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906163
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.962
Kidney Chromophobe_KICH_TCGA-KL-8346-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26582498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38496
K562_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152401
Huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
496100337_HIP_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55368
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-1826-SM-3GIL1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21544
vesicle-mediated transport	GO Biological Process Annotations 2015	1.0	null
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.121988
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.885785
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4791
hexamethonium bromide-4965	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K69718434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16229
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28733
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13759
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.46675
SH3GLB1	Pathway Commons Protein-Protein Interactions	1.0	null
collagen	GeneRIF Biological Term Annotations	1.0	null
ACSF2	Pathway Commons Protein-Protein Interactions	1.0	null
MTA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44538
SKP1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.354802
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86243
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-326	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94W-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20033
BRD-K55104181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08716
GTEX-XUZC-0926-SM-4BOQF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00287
STARD7	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5715_KO_Chaf1a_ERP006640	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.4627
BRD-K13938991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35932
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88441
GSE198228,GSE198245_0_v_2_apoe_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STK38	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-MR-A520-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
isoflupredone-5545	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5566
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Supplementary_Data_7_ZZZ3_occupied_genes_and_overlaps_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.19119
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
FGD3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-let-7b-5p	MiRTarBase microRNA Targets	1.0	null
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.829326
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE230263,GSE230265_5_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Retromer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.011
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24923
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
vesicle fusion	GO Biological Process Annotations 2023	1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K35124958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13962
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
WSUDLCL2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.91701
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.956435
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A44B-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.848927
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HN-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastric cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.298
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98308
Coelomic fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.159
late endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K88179337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22363
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970138
GTEX-X5EB-1426-SM-46MVW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867825
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.453903
u266	HPA Cell Line Gene Expression Profiles	1.0	0.833375
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EXOC6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K83115645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06248
GSE158834_2_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05971
lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-PWOO-0326-SM-48TDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8314
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAPPC4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13214
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
lysosome	GeneRIF Biological Term Annotations	1.0	null
SKRC20	DepMap CRISPR Gene Dependency	1.0	2.4129
UVSSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1416
Organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.909
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290825
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06483
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.202346
BRD-K60521891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18305
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13351
PMC5504824-12918_2017_442_MOESM2_ESM.xls-ELP_complex-Elp1_Elp3_NR5A1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3t6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.957
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GABP-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
zaprinast-5349	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-DX-A8BN-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.91453
SNX1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014781
atropine-7219	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.902083
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48020855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0744
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169988
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.61795
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24465
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCR10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04033
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09531
pergolide-7031	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2721-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K25305749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30659
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.991163
BRD-K94344573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.70272
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.39931
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.565091
Lung squamous cell carcinoma_LUSC_TCGA-56-1622-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
resveratrol-595	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.028423
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.095638
RPS6KA5	Pathway Commons Protein-Protein Interactions	1.0	null
cell lysate	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235167
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970149
GTEX-U3ZM-0926-SM-4DXSW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09684
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311336
CDK11A	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.184547
late	GeneRIF Biological Term Annotations	1.0	null
BRD-K14417813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17657
BRD-K94518115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03741
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.446
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNAPIN	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A53B-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4268	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
7142_RBBP6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06788
DOCK1	Pathway Commons Protein-Protein Interactions	1.0	null
late endosome membrane	GO Cellular Component Annotations 2015	1.0	null
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NEC8	GDSC Cell Line Gene Expression Profiles	-1.0	-2.40083
WSU-DLCL2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.91453
mannosyl-oligosaccharide 1,2-alpha-mannosidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.684
Rectum adenocarcinoma_READ_TCGA-F5-6813-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.65664
hsa-miR-4436b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
RFX5	ENCODE Transcription Factor Targets	1.0	null
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
benzonatate-1679	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.77444
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	1.64606
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37427
Prostate adenocarcinoma_PRAD_TCGA-EJ-7794-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-518a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
H3K9me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-450b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
STX18	Pathway Commons Protein-Protein Interactions	1.0	null
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
proguanil-3505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Endolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.341
OC316	DepMap CRISPR Gene Dependency	1.0	3.1838
all	GWASdb SNP-Phenotype Associations	1.0	0.030872
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
BRD-K56384677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19927
BRD-K17395396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49332
KMS20	CCLE Cell Line Gene Expression Profiles	1.0	2.38473
Perturb_7679_KD_NBAS_SRP267245	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K67905771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04527
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12957
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1910	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99638698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49893
MAP2K4	Pathway Commons Protein-Protein Interactions	1.0	null
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.91791
GTEX-X5EB-0426-SM-46MVY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.54816
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10008
fludrocortisone-282	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VAC14	Pathway Commons Protein-Protein Interactions	1.0	null
monocrotaline-1757	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STX5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XMK1-1026-SM-4B65H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9418
HCMV_24Hour-Infection_only_21084488_GSE24238	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.2223
noretynodrel-1696	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K51215422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07786
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5873
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5443-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3YL-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34954550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04489
GSE146687_2_v_0_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dynein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.584
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RAB25	Pathway Commons Protein-Protein Interactions	1.0	null
SEC61G	Pathway Commons Protein-Protein Interactions	1.0	null
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.01282
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03706
CUX1	Pathway Commons Protein-Protein Interactions	1.0	null
likely	GeneRIF Biological Term Annotations	1.0	null
H4C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82235
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26103
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE148657_3_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.41196
SNX13	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24135
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.07104
SH2D3A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K55927371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98991
GTEX-R55C-0626-SM-2TF4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34631
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46943
ANKFY1	Pathway Commons Protein-Protein Interactions	1.0	null
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17798
GSE198165,GSE198166_6_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138151
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU638	DepMap CRISPR Gene Dependency	1.0	3.16041
PHF8	ENCODE Transcription Factor Targets	1.0	null
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prospore membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.131
TAP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_PRL3_4SU_DDX21_Overlap_162_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00411149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22124
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29X-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.919606
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.160063
USO1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPJH-0626-SM-4IHJN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994543
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884057
HIP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K64692525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17722
rab9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.729
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01631
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289172
kidney disease	GWASdb SNP-Disease Associations	1.0	1.11485
BRD-K25649596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53925
GSE210377_0_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Proventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.034
H3K9me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZFX-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Viral Infection Pathways	Reactome Pathways 2024	1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
LSG1	Pathway Commons Protein-Protein Interactions	1.0	null
MSTO211H	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33224
K562_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146943
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12575
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
pipenzolate bromide-3460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.17804
macroautophagy	GO Biological Process Annotations 2025	1.0	null
H3K36me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.14136
neomycin-1383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10087
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A41208012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68058
Lung squamous cell carcinoma_LUSC_TCGA-58-8390-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1539	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
EMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14654
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3909
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248904
BRD-K94277689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04818
hsa-miR-4429	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
Salmonella infection	KEGG Pathways 2026	1.0	null
FGD4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52293
GSE199606_3_v_0_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
oxolamine-3344	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RHOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21277
RFX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-18-VX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435583
CRCGN015_MCF10A_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6548
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-T7-A92I-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00022
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07456
ARHGEF1	Pathway Commons Protein-Protein Interactions	1.0	null
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29527
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19046
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19756
Brain Lower Grade Glioma_LGG_TCGA-HT-7608-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EIF3M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04983
late endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.748641
Otx2_KO_GDS4440_143_mouse_fourth ventricular choroid plexus tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45851
GTEX-S4Q7-0326-SM-3K2B1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899163
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6872
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-7004-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33413
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061785
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8384
A549_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119412
SNTB2	Pathway Commons Protein-Protein Interactions	1.0	null
TTC19	Pathway Commons Protein-Protein Interactions	1.0	null
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469901
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.83495
BRD-K94444134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97032
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22069962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0245
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.241
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00591
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCEE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24467
HT-1080	GDSC Cell Line Gene Expression Profiles	1.0	1.99036
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE182680,GSE182683_10_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4311
picotamide-2233	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712452
piperacetazine-7191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3824
SJSA-1	GDSC Cell Line Gene Expression Profiles	1.0	1.54747
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964156
Acute Myeloid Leukemia_LAML_TCGA-AB-2848-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24825
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.881366
GOLPH3	Pathway Commons Protein-Protein Interactions	1.0	null
Coated membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.807
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1869	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70074
Vacuolar transporter chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.366
Perturb_5973_KD_TCF25_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.77038
BRD-K92722247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06415
OA-54-FL10_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283599
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950597
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.874315
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51219
Endocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.94
HS 675.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05665
organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.308122
SPIB	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28546
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03602135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05449
K562_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183042
TRAPPC3	Pathway Commons Protein-Protein Interactions	1.0	null
bacteroid-containing symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.079
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6495
BRD-K18801549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23204
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SCAMP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE178255_5_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C8166	CCLE Cell Line Gene CNV Profiles	1.0	1.39461
hsa-miR-223	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CI-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.947977
GTEX-PLZ6-0126-SM-48TC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28547
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.07707
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.89195
GTEX-WOFL-0726-SM-3MJG4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857134
RPS6KA4	Pathway Commons Protein-Protein Interactions	1.0	null
polyomavirus	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-3611	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
HOOK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5016
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34837
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arthrogryposis	DisGeNET Gene-Disease Associations	1.0	null
lung disease	GWASdb SNP-Disease Associations	1.0	0.532681
HLA-B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36104357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37551
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
F36P	DepMap CRISPR Gene Dependency	1.0	3.06954
NEK6	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_5971_KD_TAF15_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.51009
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
MZ in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.943085
GSE128563_2_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328886
CRCGN016_MCF10A.TP53.M_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24105
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.703267
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69431
PMC4590607__F3	PFOCR Pathway Figure Associations 2024	1.0	null
18508997-Figure2	GeneSigDB Published Gene Signatures	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55E-0126-SM-2TC5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95565
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0227
Golgi stack	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.17
CRCGN008_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2649
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34004
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6088
FKBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18183
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSC5	DepMap CRISPR Gene Dependency	1.0	2.1879
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NFK9-0726-SM-2HMJW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.24755
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EXOC5	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WD-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Fast Acetylator Due To N-Acetyltransferase Enzyme Variant	DisGeNET Gene-Disease Associations	1.0	null
PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OE-31-YC41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315729
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
sulfadiazine-5523	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FERMT1	Pathway Commons Protein-Protein Interactions	1.0	null
NCCSTCK140	CCLE Cell Line Gene Expression Profiles	1.0	2.23571
SACM1L	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76635
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059009
miR-targeted genes in epithelium - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
BRD-K11476310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22878
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6983-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120248,GSE120252_1_v_0_macf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Mucopolysaccharidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.885785
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33761
TBC1D17	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
RPS6KA3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YT-0926-SM-48TDG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865214
P300-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CLASP2	Pathway Commons Protein-Protein Interactions	1.0	null
although	GeneRIF Biological Term Annotations	1.0	null
BRD-K14653235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06519
PMC5031867-mmc2.xlsx-RYTTCCTG_V_ETS2_B-GENE_SYMBOL_ETS2	Rummagene Transcription Factor Associations 2026	1.0	null
ATP6V1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06875
MOLP2	CCLE Cell Line Gene Expression Profiles	1.0	2.20613
hesperetin-1947	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7416-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DHX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84268
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934589
MEIS1-26253404-OPTIC-CUPS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FNIP-folliculin RagC/D GAP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.524
SOX9	ChEA Transcription Factor Targets	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594664
Dystonia 30	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.860437
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prestwick-675-2187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.998006
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_6_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84956158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0926
STAT3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.3
BRD-K17245631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23726
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.063419
intracellular transport	GO Biological Process Annotations 2015	1.0	null
BRD-M39894156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51359
BRD-K43206373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58729
BRD-K32882942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42028
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_8699_KD_FTO_SRP213118	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.4584
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.364
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDIPT	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05698
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36164
ZWILCH	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09560946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19047
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.00044
B3GALT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01361
BRD-K81757081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03086
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70148902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37983
troglitazone-370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCDC186	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6349
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAD2L1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AP3S1	Pathway Commons Protein-Protein Interactions	1.0	null
DGKQ	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01577807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31109
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.991009
GTEX-O5YW-0126-SM-3LK6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46679
STX4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
PKIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06796
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99413603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35512
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210492
Vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.473
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09832
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.15687
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.74877
suxibuzone-7163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FGFR1_mutant_25_GDS4046	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.1967
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11263707-41419_2024_6896_MOESM4_ESM.pdf-17-ZNF367_ZNF367	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214954
FLI1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43849
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB1A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE199606_2_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13271
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74005
endosomal part	GO Cellular Component Annotations 2015	1.0	null
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K26863838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05575
Late endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.154
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50023
late endosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
T-24	GDSC Cell Line Gene Expression Profiles	1.0	1.85261
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83843
VPS16	Pathway Commons Protein-Protein Interactions	1.0	null
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08919
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PPP1R3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62631
DYNC1I2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.830169
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13877
Perturb_13140_KD_Rb1_SRP158002	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.1167
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4117
cuneus, left, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14492
NCAPG	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062629
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AMDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91087
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.77965
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-A03940741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3113
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
atropine methonitrate-7253	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CSTB_KO_GDS5090_398_mouse_cerebella	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
Perturb_5959_KD_RPF2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.46854
HDAC2	ENCODE Transcription Factor Targets	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.367
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K42008693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55321
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1-22412390-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
RAB5A	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12842_KO_Tet2_SRP338315	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.61051
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39612
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.32
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SH3GL2	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A3KG-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160167
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHU-0926-SM-4E3IG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27442
hsa-miR-31	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hexylcaine-3447	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
17676974-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
GSE86507,GSE86509_3_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO679	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20243
SNX27	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUDHL10	CCLE Cell Line Gene Expression Profiles	1.0	1.44241
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.754376
Lung adenocarcinoma_LUAD_TCGA-62-A46P-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE186633_2_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWOO-0926-SM-2I3EC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955872
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chlorzoxazone-2100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
arachidonic acid-441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104496
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3746
VPS18	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XXEK-0326-SM-4BRVV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940315
GSE226233_0_v_1_pccb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dehydrocholic acid-2023	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE161864,GSE161866_1_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.179
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6977700-aging-12-102667-s004..xlsx-Stage1-The_identified_3126_dysregulated_LmiRM-CTs_in_stage_1_of_MI_1_day_of_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
BRD-K22383829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21366
BRD-K33102216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79999
SF268	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Late endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
adenosine phosphate-5359	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158100,GSE158101_1_v_0_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31155
tracazolate-7339	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TJP2	Pathway Commons Protein-Protein Interactions	1.0	null
OSBPL8	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.907
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28354175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.16285
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87546
Endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.69
1,3-beta-D-glucan synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
10-methoxyharmalan-5455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827788
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P4QS-0926-SM-48TBS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7341
GSE138468_3_v_6_dyrk1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
prednisone-1478	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Opportunistic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XAJ8-0626-SM-47JY4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00428
DNAJC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38128
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.42001
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20589
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCAP31	Pathway Commons Protein-Protein Interactions	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE239844_1_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
LB771-HNC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LP1	CCLE Cell Line Gene Expression Profiles	1.0	2.19993
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AH-1626-SM-3GAF8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17952
BRD-K33697018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4402
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.274101
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24697
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.84957
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5838-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2218	GDSC Cell Line Gene Expression Profiles	-1.0	-1.86644
CCT4	Hub Proteins Protein-Protein Interactions	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.885785
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
RAP2B	Pathway Commons Protein-Protein Interactions	1.0	null
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5587
Food vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.071
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Actin body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.65529
pirenzepine-7226	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
E2F1	ChEA Transcription Factor Targets	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SEC31A	Pathway Commons Protein-Protein Interactions	1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.1292
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051416
tanespimycin-6986	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
miR-targeted genes in lymphocytes - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21154
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
endosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
benzbromarone-1291	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905072
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.568
UBTF	ENCODE Transcription Factor Targets	1.0	null
KBTBD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10114
FOXP2	ENCODE Transcription Factor Targets	1.0	null
BRD-K19089958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06842
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02515
GTEX-QDT8-0126-SM-48TZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939394
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CE-15-YU05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315833
Perturb_10766_KO_Thbs1_SRP164677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.39307
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395684
smad3	GeneRIF Biological Term Annotations	1.0	null
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KIAA0196	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Upregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
TROVE2	Hub Proteins Protein-Protein Interactions	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.512429
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-939	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
ATP6V1H	Pathway Commons Protein-Protein Interactions	1.0	null
ARFGEF2	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCF7_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242802
PIK3R4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7383
hsa-miR-4646-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
U87	BioGPS Cell Line Gene Expression Profiles	1.0	0.885643
Phagophore assembly site membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.111
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16344
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17351
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.940229
pheniramine-1910	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277285
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ULK1_knockout_197_GSE60778	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.36573
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X5EB-1926-SM-4E3IW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15166
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
OSBPL11	Pathway Commons Protein-Protein Interactions	1.0	null
ARHGEF26	Pathway Commons Protein-Protein Interactions	1.0	null
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Germ tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.814
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
PDGF_ERK_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
SARS-CoV-2-host interactions	Reactome Pathways 2024	1.0	null
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32301
GSE103122_0_v_1_riok3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
skeletal muscle	HPA Tissue Protein Expression Profiles	1.0	1.66851
SUDHL8	DepMap CRISPR Gene Dependency	1.0	3.20479
retrorsine-4946	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AR	ChEA Transcription Factor Targets	1.0	null
GTEX-PX3G-2626-SM-2I3EG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94496
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39438
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-527	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UPK5-1626-SM-4JBHI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23877
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.87809
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3904
PPP2R1B	Pathway Commons Protein-Protein Interactions	1.0	null
JHOS2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36279
pentetrazol-1408	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
valproic acid-1181	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prestwick-857-3355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hypopigmentation-Immunodeficiency Disease	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PH-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Severe COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
TRIP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12137
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BLOC-3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.082
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Protein storage vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.675
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.562253
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.71331
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.76757
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
facilitating	GeneRIF Biological Term Annotations	1.0	null
GTPBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE148321,GSE169423_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54043
EGFR_OE_GDS1925_167_human_Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1226-SM-3GACY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833728
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81D-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87982
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
TIE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58681
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.186066
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01383
TORC1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.012
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0735
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
endosome membrane	GO Cellular Component Annotations 2015	1.0	null
B-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
SU-DHL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60994
spinal trigeminal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.855049
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16159
RANBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gtr1-Gtr2 GTPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.442
TBC1D4	Pathway Commons Protein-Protein Interactions	1.0	null
vesicle-mediated transport	GO Biological Process Annotations 2023	1.0	null
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.942035
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8157
CRO-AP2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09507
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37259
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A641-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4081-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ragulator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.123
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16237
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75479
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
tamoxifen-143	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SPSB1	Hub Proteins Protein-Protein Interactions	1.0	null
BT20_BREAST	CCLE Cell Line Proteomics	1.0	2.26318
BRD-K10385824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22541
Apical cortex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.553
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.00809
MOLT-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9316
KM-H2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61924
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EHD4	Pathway Commons Protein-Protein Interactions	1.0	null
496100415_PCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51556
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.993572
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A96537953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00266
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EMC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.945
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45348
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249557
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2265
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04014
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04173
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2786
epiandrosterone-5687	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
16081686-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
Larval serum protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.036
Sarcoma_SARC_TCGA-DX-A3UC-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.99778
vinpocetine-1557	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VPS33A	Pathway Commons Protein-Protein Interactions	1.0	null
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.835857
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU668	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6705
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.325
PRMT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04765
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49752
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10741
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36274
DNM1L	Pathway Commons Protein-Protein Interactions	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051778
HSC3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68803
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7413-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUZC-0226-SM-4BOO7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47025
BRD-K43981353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40067
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
acebutolol-1911	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RMND1	Pathway Commons Protein-Protein Interactions	1.0	null
STAT5A	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.73476
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.04066
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04975
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6138639-41467_2018_6247_MOESM5_ESM.xlsx-S2_7_ChIP-seq_RNA-seq_overlaps-49_common_elements_in_ZZZ3_bound_and_shZZZ3_Up_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.922357
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.7837
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Skin carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.543
ING4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42384
cytoplasmic vesicle membrane	GO Cellular Component Annotations 2025	1.0	null
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37751
mercaptopurine-334	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A902-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Y-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24312231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38294
bupropion-6256	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE229580_0_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
mvps39	GeneRIF Biological Term Annotations	1.0	null
GTEX-XQ3S-2526-SM-4BOOG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978084
CSNK2A2	Pathway Commons Protein-Protein Interactions	1.0	null
endosome to lysosome transport	GO Biological Process Annotations 2023	1.0	null
U343	CCLE Cell Line Gene Expression Profiles	1.0	1.55592
BRD-K21819164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34504
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RB1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
trans-Golgi network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.038
Lysosomal membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21819
RAB43	Pathway Commons Protein-Protein Interactions	1.0	null
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K50315405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1594
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21154
BRD-A61522392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32946
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Storage vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.647
ABR	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78475
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.414555
BRD-K68547601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37397
BRD-K13551202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58494
BRD-K67016489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01431
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_10_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
PPP2R2A	Pathway Commons Protein-Protein Interactions	1.0	null
IDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02234
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241311
arc syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.7159
GSE226249_2_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K43714461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66121
tiratricol-7011	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90013
tgfbeta	GeneRIF Biological Term Annotations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48284
GTEX-R3RS-0726-SM-3GIJR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857153
GSE178255_2_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NTRK3_drugactivation_67_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.00794
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cytoplasmic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.202
Lung adenocarcinoma_LUAD_TCGA-50-5942-01A-21R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE190186,GSE190188_8_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5913_KD_HDLBP_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.96377
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endoplasmic reticulum-vacuole membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.41
PMC8384902-mmc5.xlsx-H2107_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61908
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Yolk granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.778
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.132
ERI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49186
HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863569
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Calu-3	GDSC Cell Line Gene Expression Profiles	-1.0	-2.44841
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
K562_Alisertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185025
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.941
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0079
BRD-K19829092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48742
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.073844
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
penbutolol-7476	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7670-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06605
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
flunixin-3411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATP6V1C2	Pathway Commons Protein-Protein Interactions	1.0	null
tacrolimus-284	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IRF9	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2710-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4448	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
HH	CCLE Cell Line Gene CNV Profiles	-1.0	-1.88677
b16-f10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.766539
BRD-K42181022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34821
GSE225869_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
OSBPL3	Pathway Commons Protein-Protein Interactions	1.0	null
Chediak-Higashi syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.52
Exocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.823
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14215
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.70745
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.95198
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04254
GTEX-S341-0126-SM-4AD64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69804
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
PIK3R1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K29702569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24723
METTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96023
GSE166169_0_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15374
Basolateral recycling endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
UBXN6	Pathway Commons Protein-Protein Interactions	1.0	null
4-hydroxyphenazone-1997	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.854184
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85673
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75909618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06206
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64409
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5680-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80518
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CORL24	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88684
PMC6464042__F6	PFOCR Pathway Figure Associations 2024	1.0	null
PMC10714175-mmc2.xlsx-KD_Gene_list-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162087_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
omeprazole-6606	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
gabapentin-7229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K74665927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23763
wortmannin-404	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NRL_Deficiency_GDS1693_236_mouse_Photoreceptors cells of retinas at P2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
LP1	DepMap CRISPR Gene Dependency	1.0	2.02068
BRD-K08036779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08263
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77309
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_0Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.632019
BRD-K58715359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01571
GTEX-OOBJ-2626-SM-2I3F6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42883
oltipraz	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37276
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21176869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48227
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35632
CLCN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35559
H3K27ac_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU349	DepMap CRISPR Gene Dependency	1.0	2.54546
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
anterior group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.980834
BRD-K83189379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35126
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3749
Trichocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PLEKHF2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-10-NA60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254661
BRD-K90951880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0968
KASUMI-1	GDSC Cell Line Gene Expression Profiles	-1.0	-3.53725
GSE245270_1_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
phenazone-1989	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Efferocytosis	KEGG Pathways 2026	1.0	null
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136544
NF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76515685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21744
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.66942
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pinosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.825
EXOC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06341
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
rifabutin-3873	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.297713
methylprednisolone-3183	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endosome membrane	GO Cellular Component Annotations 2025	1.0	null
Citron-like	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RAB21	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.12778
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.969122
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QXCU-0326-SM-2TC63	GTEx Tissue Sample Gene Expression Profiles	1.0	2.97116
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
methyldopa-1619	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8064
Membrane fusion priming complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.459
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hermansky-pudlak syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.0206
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SNX17	Pathway Commons Protein-Protein Interactions	1.0	null
diazoxide-2214	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
trazodone-7452	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE185944_2_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hek-293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.452584
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25704
CHD2	ENCODE Transcription Factor Targets	1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19291
coated membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.211933
HCC1599	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42883
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.885785
BRD-K67014046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18011
proguanil-5506	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_12843_KO_Tet2_SRP338315	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.18749
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.45042
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.798559
Yolk	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.737
thalidomide-266	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
fulvestrant-704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K97013733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23719
Cloneh	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
GSE239844_6_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
rofecoxib-205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATP6V0C	Pathway Commons Protein-Protein Interactions	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ITPK1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-129-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
triprolidine-7008	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CSNK1D	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-Y6-A8TL-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6111
KARPAS422	CCLE Cell Line Gene Expression Profiles	1.0	1.63837
BRD-K05475322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1838
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.57588
ESCRT II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.239
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195559_6_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02548315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09857
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133502
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.823997
alclometasone-6229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7072
ARHGAP8	Pathway Commons Protein-Protein Interactions	1.0	null
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250519
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.74047
GTF3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17664
BRD-K29614616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46181
GSE252857_2_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01377
KARPAS299	DepMap CRISPR Gene Dependency	1.0	3.01424
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3236
GSE75209,GSE75212_0_v_1_halofuginone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
lysosomal membrane	GO Cellular Component Annotations 2025	1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STEAP3	Pathway Commons Protein-Protein Interactions	1.0	null
RHOT2	Pathway Commons Protein-Protein Interactions	1.0	null
sulpiride-1467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.2719
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNX6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00422
ARHGAP18	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.836
Vesicle tethering complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100613_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01035
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26327
BRD-K10452371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14362
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44597
root	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.22415
GSE124410_6_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
troleandomycin-1965	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23599
endoplasmic reticulum part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.166167
Dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285521
cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.270068
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00816476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2912
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2031_KO_Chd4_SRP079694	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.9681
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Peripheral_Blood_Mononuclear_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.848403
mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.135981
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH69	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57329
lysosomal transport	GO Biological Process Annotations 2023	1.0	null
GSE185865_0_v_1_celf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61236
Prepupa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.885
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49416
lung_3f	HPA Tissue Sample Gene Expression Profiles	1.0	0.885511
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837432
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A24436948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29734
GSE135439_0_v_1_pax5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDVN-0626-SM-2I3FP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13568
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.80153
NCIH2122	CCLE Cell Line Gene CNV Profiles	1.0	1.937
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60582
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.119134
hops complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
AGK	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4428	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.839249
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.91627
BRD-K45663146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52721
Perturb_11631_KD_HSPC182_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.33846
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-1926-SM-32QOS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872931
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.916
etofylline-1409	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0526
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.079
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
BRD-K29178949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44947
BRD-K98961458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01756
Apical plasma membrane urothelial plaque	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.631
CEBPB	ENCODE Transcription Factor Targets	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC42	Pathway Commons Protein-Protein Interactions	1.0	null
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.896375
Hyphal cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.706
GTEX-SN8G-1526-SM-4DM79	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09635
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A75607876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28798
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
X-linked spinocerebellar ataxia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
C1QBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92318
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13761
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U3-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190186,GSE190188_0_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19828
ERBB2_druginhibition_8_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.56172
STOML2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334631
Infectious disease	Reactome Pathways 2024	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.27338
CISD2	Pathway Commons Protein-Protein Interactions	1.0	null
HOOK1	Pathway Commons Protein-Protein Interactions	1.0	null
TULP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20237
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963112
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-6846-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.19386
endomembrane system	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.276304
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27178
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IST1	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059257
GTEX-RWSA-2026-SM-47JX8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.99669
LRBA	Pathway Commons Protein-Protein Interactions	1.0	null
VAV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45258
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.89805
memantine-7354	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE111102,GSE111105_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDC42BPG	Pathway Commons Protein-Protein Interactions	1.0	null
GSE229344_1_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_4_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
OTX2_KO_GSE27630_51_mouse_brain (fourth ventricular choroid plexus, E13)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7902
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065445
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.75742
H3K36me3_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
meticrane-1834	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YD15	DepMap CRISPR Gene Dependency	1.0	2.01537
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907795
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOOK2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4159-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Autophagy - animal	KEGG Pathways 2026	1.0	null
amikacin-1618	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880974
U2SURP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11353
ANAPC7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K96567801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27685
Hybridoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.243
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Phagolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.579
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06885
Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.93555
FLI1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-S4Q7-1026-SM-4AD75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86072
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30422
GTEX-WFG8-1826-SM-4LVM4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59802
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1852
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.95856
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1526
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38998073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64796
BRD-K95485901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06422
Lung squamous cell carcinoma_LUSC_TCGA-63-5128-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43205312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44626
Endolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.678
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bucladesine-3483	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERBB3_knockdown_65_GSE19921	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.3548
BRD-K97421379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46327
NRF1	ENCODE Transcription Factor Targets	1.0	null
PMC4590607__F3	PFOCR Pathway Figure Associations 2023	1.0	null
late endosome membrane	GO Cellular Component Annotations 2023	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8986524__F3	PFOCR Pathway Figure Associations 2024	1.0	null
ARL15	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE161295_2_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAM229A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63719
GTEX-P4PQ-0126-SM-2S1NM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871312
Vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.735
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
59M	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63126
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4P3-0226-SM-3K2BD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854851
PMC4219345-1471-2121-14-52-S3.xlsx-BORIS_hNP1-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014002
GSE152699,GSE152723_0_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perinuclear region of cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.866
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A149-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240468_3_v_2_nfyc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Intracellular immature spore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.096
FOXI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12286
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19493
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
E2F1-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8097-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.717581
hsa-miR-4736	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE190186,GSE190188_0_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KM12	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.54016
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922145
USP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08369
mesoridazine-7017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.988344
cytisine-6217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pirenzepine-1388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH660	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73403
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838226
CSNK2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24523
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-2226-SM-2XCAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884046
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18727
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36161
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
sulfathiazole-4769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bumetanide-7440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K96076719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04853
hsa-miR-320b	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
BRD-K45894579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61266
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82883803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43431
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.95036
GSE211866_2_v_1_usp11_human	RummaGEO Gene Perturbation Signatures	1.0	null
STAM	Pathway Commons Protein-Protein Interactions	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIPK2_defectivemutant_29_GDS4233	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.68384
CBX3	ENCODE Transcription Factor Targets	1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TM9SF1	Pathway Commons Protein-Protein Interactions	1.0	null
PGD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10335
clemastine-7443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Peeling skin syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
hsa-miR-876-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.244962
GSE165307_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EXOC3	Pathway Commons Protein-Protein Interactions	1.0	null
Ebolavirus(EBOV)_3day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.19508
BRD-K03765511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48952
BRD-K86240647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08749
Anaplastic thyroid cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.125
BRD-K24883912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23553
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16135
GATA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05954
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.169484
RUNX1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
heart	GTEx Tissue Gene Expression Profiles	-1.0	-0.854025
BRD-K07336866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16073
pempidine-6027	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
uterine cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LU99	DepMap CRISPR Gene Dependency	1.0	2.13184
Recycling endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.558
Endoplasmic reticulum-Golgi intermediate compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.299
NCIH211	DepMap CRISPR Gene Dependency	1.0	2.79233
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.40134
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.74265
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K32853527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14918
PSAP	Pathway Commons Protein-Protein Interactions	1.0	null
Autolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.852
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19505
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052484
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284923
TAF1	ENCODE Transcription Factor Targets	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04975
Protozoan Infection_Intestinal Epithelium_GSE2077	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.99434
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26871
L363	DepMap CRISPR Gene Dependency	1.0	3.52985
BRD-K31546068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20007
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.44594
cytoplasmic vesicle membrane	GO Cellular Component Annotations 2023	1.0	null
KICSTOR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.89
lysosomal HOPS complex	GO Cellular Component Annotations 2023	1.0	null
CDK9_druginhibition_183_GSE48258	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.084975
BRD-A14183911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7127
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellularly	GeneRIF Biological Term Annotations	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lysosomal membrane	GO Cellular Component Annotations 2023	1.0	null
Golgi trans cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.663
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.904531
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A819-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
supramarginal gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.853049
vacuolar part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910193
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K73296174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39265
RANGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
AP1S1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K30019337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16207
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
dihydrostreptomycin-6228	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.977765
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PQ-2626-SM-33HC9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27737
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
red nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29519
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04608
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01378
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.646
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64057
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.75943
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09657
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18847
BRD-K40894545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15714
USE1	Pathway Commons Protein-Protein Interactions	1.0	null
COLO800	CCLE Cell Line Gene CNV Profiles	1.0	1.61037
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11236
GTEX-T5JW-1326-SM-4DM5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3929
BRD-K33179234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75915
ILF3-29590119-K562-HUMAN-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
VTA1	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
valproic acid-346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.353282
NCI-H596	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218171_1_v_0_foxn3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338418
GDI2	Pathway Commons Protein-Protein Interactions	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
BRD-K35681049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03194
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chr15_42166149_T_C_b38	GTEx eQTL 2025	1.0	1.45035
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858722
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11241
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Phosphatidylinositol 3-kinase complex, class III, type II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.337
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23108
hsa-miR-612	TargetScan Predicted Conserved microRNA Targets	1.0	0.078844
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
LACTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50967
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324768
Lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.585
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.85891
GSE256181_2_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44212
U266B1	CCLE Cell Line Gene CNV Profiles	1.0	1.98303
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3378-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMRC3	DepMap CRISPR Gene Dependency	1.0	2.30358
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05429
organic substance transport	GO Biological Process Annotations 2015	1.0	null
MAPK13	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.22246
BRD-K64182862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11961
Brain Lower Grade Glioma_LGG_TCGA-WY-A85E-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48335
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947478
DYNLL1	Pathway Commons Protein-Protein Interactions	1.0	null
NZM3	DepMap CRISPR Gene Dependency	1.0	2.5118
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.21
ermes complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.53896
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
COLO205_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	3.91019
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10616
BRD-K76803075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25226
Fiddlehead	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
Parkinsonism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
14695196-Table2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-X8HC-0126-SM-4E3JW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19018
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5360-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mucopolysaccharidosis Ih	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
metampicillin-5540	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
disrupts	GeneRIF Biological Term Annotations	1.0	null
PPM1B	Pathway Commons Protein-Protein Interactions	1.0	null
DIAPH1	Pathway Commons Protein-Protein Interactions	1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.691652
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02023
tetrahydroalstonine-1756	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35186
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.98665
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
POLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40492
BRD-K11282060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23265
CRCGN015_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06925
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39032
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RC-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chenodeoxycholic acid-7433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
quipazine-2782	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.993012
FOXA1	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
oxamic acid-439	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.27535
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.69697
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.61467
Chloroplast vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.587
JL1	CCLE Cell Line Gene Expression Profiles	1.0	1.7255
BRD-K58242935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33276
ELK1	ENCODE Transcription Factor Targets	1.0	null
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.437403
IGDCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19542
VPS52	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K08576275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12435
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.692905
spleen_3a	HPA Tissue Sample Gene Expression Profiles	1.0	0.836984
PTPN9	Pathway Commons Protein-Protein Interactions	1.0	null
Retinal cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229968
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWCY-2326-SM-2I3EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856098
AC-92-HS43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415772
ornidazole-5483	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K03304013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32489
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6522
morphology	GeneRIF Biological Term Annotations	1.0	null
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29746
BACH1	ChEA Transcription Factor Targets	1.0	null
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29292
UMUC6	DepMap CRISPR Gene Dependency	1.0	2.83099
inferior temporal gyrus, right, bank of the its	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.843049
hsa-miR-3187-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
CCNT2	ENCODE Transcription Factor Targets	1.0	null
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42272
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15923
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35855
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2029
Lung squamous cell carcinoma_LUSC_TCGA-85-A4PA-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of protein-containing complex assembly	GO Biological Process Annotations 2025	1.0	null
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997002
hsa-miR-3192	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
K562_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027335
Central vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.263
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.659
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_424_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RN64-0626-SM-2TC5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95173
STK39	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-XJ-A83F-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
clidinium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01225
ABI1	Pathway Commons Protein-Protein Interactions	1.0	null
BGC823	CCLE Cell Line Gene CNV Profiles	1.0	1.73094
Phagocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.899
RUFY1	Pathway Commons Protein-Protein Interactions	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.74885
KOPN8	CCLE Cell Line Gene Expression Profiles	1.0	1.36933
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65318
retinal pigment epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.519253
Allpo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
TGBC24TKB	GDSC Cell Line Gene Expression Profiles	1.0	1.72779
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-0126-SM-47JY7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923122
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1944
C22orf15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21992
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RALB	Pathway Commons Protein-Protein Interactions	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NEU1	Pathway Commons Protein-Protein Interactions	1.0	null
Gut granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.676
vacuolar membrane	GO Cellular Component Annotations 2015	1.0	null
Microtubule minus-end	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.856
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K41684304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43505
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TELO2	Pathway Commons Protein-Protein Interactions	1.0	null
SUDHL4	DepMap CRISPR Gene Dependency	1.0	2.53218
BRD-K99530482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76689
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
troleandomycin-1885	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4697333__F4	PFOCR Pathway Figure Associations 2023	1.0	null
ZNF384_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STXBP3	Pathway Commons Protein-Protein Interactions	1.0	null
GTPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.89
Golgi-associated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.237
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
XPO6	Pathway Commons Protein-Protein Interactions	1.0	null
MK-886-601	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SEPT10	Pathway Commons Protein-Protein Interactions	1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TSC1-TSC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.389
Kinesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.526
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
blastula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.255567
Membrane microdomain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.834
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.875119
H4K20me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.6822
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.999014
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7537
BRCA1	ENCODE Transcription Factor Targets	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.75915
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278297
GSE57871_8_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COPI-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.427
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
VPS36	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42586
URGCP	Pathway Commons Protein-Protein Interactions	1.0	null
PITPNM1	Pathway Commons Protein-Protein Interactions	1.0	null
claustrum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.911886
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
WDFY3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AH-0826-SM-48TZN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928906
Lung squamous cell carcinoma_LUSC_TCGA-85-8664-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CC-70-BD07_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347184
PrPC_KO_GDS4352_359_mouse_Developing hippocampus from adults (3-mo-old)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
sulindac-307	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RFX7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0916
DANG	DepMap CRISPR Gene Dependency	1.0	2.65871
ATR	Pathway Commons Protein-Protein Interactions	1.0	null
Pupal wing	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
celecoxib-252	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE211357_1_v_3_atg7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DC-63-KC77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207409
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0325
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42523
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.91453
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
antigen	GeneRIF Biological Term Annotations	1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mammary Neoplasms	DisGeNET Gene-Disease Associations	1.0	null
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SK-MES-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159991
Perturb_5935_KD_MYBBP1A_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.64452
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
8-azaguanine-1670	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26889
tn5b14	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
esculin-5411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC827GR5	DepMap CRISPR Gene Dependency	1.0	2.25405
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53917
BRD-K57516590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00134
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.297713
GSE211474,GSE212779_0_v_1_phf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4051124-1471-2164-15-256-S15.XLSX-WES_IPD-RBCK1_1-Target_RBCK1	Rummagene Transcription Factor Associations 2026	1.0	null
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.7821
RPS6KA1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Merkel cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.872
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94856
Perturb_5894_KD_CBX5_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.11074
RBM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65675
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.88665
liver	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
RL	DepMap CRISPR Gene Dependency	1.0	2.34659
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBJ-0926-SM-48TDO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12136
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2937
a431	HPA Cell Line Gene Expression Profiles	-1.0	-0.941206
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
substantia innominata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.938034
hsa-miR-3977	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
cortico-medial group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.70854
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5963_KD_SETDB1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.64917
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
indometacin-7409	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SKBR3	DepMap CRISPR Gene Dependency	1.0	2.84725
CIB1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05281
BRD-A81260764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19641
lateral hypothalamic area, tuberal region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.872021
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1299
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.230478
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911654
CAPAN-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.21911
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8333
HBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14232
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60127720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06402
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.846947
BRD-K09721867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26574
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29821
MOLM-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autolysosome lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.212
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K79299080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05403
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33807
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.663681
BRD-A59391763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30087
EF-80-OD07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325832
SCARB2	Pathway Commons Protein-Protein Interactions	1.0	null
RAB35	Pathway Commons Protein-Protein Interactions	1.0	null
DOPEY2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K06614664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.134
UO31	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.92321
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967827
ITK_knockout_242_GSE12465	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.65647
SMAD4	Pathway Commons Protein-Protein Interactions	1.0	null
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.867
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ERGIC1	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32207
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.414946
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1583
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826095
BRD-K27754030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16019
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043342
FIG4	Pathway Commons Protein-Protein Interactions	1.0	null
SHD	Pathway Commons Protein-Protein Interactions	1.0	null
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.53709
Late endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
postcentral gyrus, left, bank of the posterior central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.846622
R-atenolol-4841	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP in perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.898805
G415	DepMap CRISPR Gene Dependency	1.0	2.89351
Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23543737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01482
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
EE-98-PF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.380323
GSE250534_4_v_1_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9763
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Golgi-associated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.414
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921323
BRD-K27229533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55307
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87742870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26729
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131186
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Basophilic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.808
PMC8065135-41467_2021_22068_MOESM6_ESM.xlsx-E_MYOG_binding_in_downreg-Unnamed_1_MYOG	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.54145
BRD-K64266251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14215
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
sulfadiazine-1852	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
geldanamycin-593	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995016
Anchored component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
BRD-K72661036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3913
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943381
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Charcot-Marie-Tooth disease type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
nitrofurantoin-7373	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OIP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17837
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
HS939T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76536
SARS-CoV MA15_Day4-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.77207
GSE115395_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
N-phenylanthranilic acid-317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
epivincamine-1783	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K34985075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33291
Uterine endometrial cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATG3	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-7950-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35742
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
GTEX-P4QT-2626-SM-2I3FM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34147
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14332
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Primary lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.657
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.13093
calcium pantothenate-1311	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K72336314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03648
SIN3A	ENCODE Transcription Factor Targets	1.0	null
aminohippuric acid-6453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sulfamethoxazole-3667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAP1S	Pathway Commons Protein-Protein Interactions	1.0	null
Cohen syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
transport	GO Biological Process Annotations 2015	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
GTEX-RNOR-0926-SM-2TF56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34339
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4488
H1_BMP4_Derived_Mesendoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.30929
CMTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18948
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.371982
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60218
endosomal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.605284
symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.695148
GTEX-XBEC-0326-SM-4AT4M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01441
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WN-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPK-2626-SM-2HMK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16158
MYO6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A45349889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15319
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
UPCISCC116	DepMap CRISPR Gene Dependency	1.0	2.64825
GTEX-PSDG-0226-SM-33HC1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08556
GSE235828_3_v_2_igf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A44A-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VPS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29939
e2f2_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.866591
Microneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.918
ifenprodil-7404	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064292
lysosome	GO Cellular Component Annotations 2025	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.934311
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
RAB13	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K91180296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37204
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28106
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23104
REPS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KIF11	Pathway Commons Protein-Protein Interactions	1.0	null
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cytostome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.714
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.851722
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HTT	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWO3-0011-R2A-SM-2S1OX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937362
RIN1	Pathway Commons Protein-Protein Interactions	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.91255
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CGTH-W-1	GDSC Cell Line Gene Expression Profiles	1.0	1.63085
GTEX-PLZ5-2026-SM-2S1O4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57284
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-323-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
PAS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.659
BRD-K55836749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30596
BRD-K63716942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48304
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3828
BRD-K42679620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23608
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16079077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25993
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
BRD-K67572910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30294
vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
cis-Golgi network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.631
Brain Lower Grade Glioma_LGG_TCGA-HT-8564-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04848570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48044
H1_Cell_Line	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.11709
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.62311
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0054
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Rhoptry	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.018
MERO14	DepMap CRISPR Gene Dependency	1.0	2.64925
NAAA	Pathway Commons Protein-Protein Interactions	1.0	null
BRAF_druginhibition_175_GSE42872	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.89936
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SEL1L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67096761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13813
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75326
Compound eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945
PMC11951866-mmc1.pdf-3-FOXK1_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.23162
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.26312
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6209
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-0526-SM-48TZ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54799
MAX	ENCODE Transcription Factor Targets	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855636
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54836449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49701
CPCN	CCLE Cell Line Gene CNV Profiles	1.0	1.5634
GTEX-WFON-1626-SM-4LVMV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18761
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.850802
ZFP57-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10989535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46473
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.09345
trifluoperazine-421	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K64173373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17581
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123502,GSE123504_1_v_0_chd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226793_1_v_0_ccr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K33503286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17535
MCF7_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110261
BRD-K97748753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13077
GTEX-RM2N-0126-SM-48FDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0912
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLA2G4A	Pathway Commons Protein-Protein Interactions	1.0	null
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.41422
GTEX-S95S-1026-SM-4B64M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04223
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EXPH5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEx Prostate 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-4.21523
clorsulon-7025	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.96
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.90945
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139540_4_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lysosome	GO Cellular Component Annotations 2023	1.0	null
melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.847065
MAP2K2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K40164971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15943
protein transport	GO Biological Process Annotations 2015	1.0	null
root nodule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.35557
BRD-K54067431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16059
Intracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4737-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K86454955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76595
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40893
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.65817
GTEX-WRHK-1426-SM-3MJF9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05824
STX7	Pathway Commons Protein-Protein Interactions	1.0	null
TNFSF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2144
SIGMAR1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
late endosome membrane	GO Cellular Component Annotations 2025	1.0	null
TTNPB-223	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878022
GTEX-WFG8-0126-SM-4LVMH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5545
Df	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plant-type vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.398
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02011
GTEX-SIU7-1126-SM-2XCDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26477
253JBV	CCLE Cell Line Gene Expression Profiles	-1.0	-2.44573
mp1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.654
UVRAG	Pathway Commons Protein-Protein Interactions	1.0	null
Pupa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.002
GPRC5A	Pathway Commons Protein-Protein Interactions	1.0	null
Systemic mycosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
deferoxamine-460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ARHGEF2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933843
pyrimethamine-4779	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBEW-0126-SM-4AT66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31861
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.323
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2172	DepMap CRISPR Gene Dependency	1.0	2.05952
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
carbarsone-3250	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3	Rummagene Transcription Factor Associations 2026	1.0	null
NUDC	Pathway Commons Protein-Protein Interactions	1.0	null
True leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0726-SM-4BOOP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874622
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.80697
Lung squamous cell carcinoma_LUSC_TCGA-56-8201-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZH-0626-SM-3NB1L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918799
AP-3 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.352
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160817_4_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78088874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06843
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
clathrin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.305515
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prestwick-967-7346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
UNKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38826
GTEX-NFK9-1726-SM-3TW8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96985
GTEX-V1D1-0926-SM-4JBHQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.769
Omegasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.305
CAMA1	CCLE Cell Line Gene CNV Profiles	1.0	1.41948
BRD-K66327237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79877
BRD-K41206520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42121
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10318
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANXA6	Pathway Commons Protein-Protein Interactions	1.0	null
lytic vacuole membrane	GO Cellular Component Annotations 2025	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25079
Tubular endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178255_3_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERGIC2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8012-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165856
Perturb_5945_KD_PPHLN1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.34406
late endosome	GO Cellular Component Annotations 2023	1.0	null
Embryonic brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
Mammary Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.69801
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.899926
PDZD8	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170048
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-0526-SM-2I3DX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16617
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39752756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48172
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952021
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51511
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97485956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04244
Gas bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.836
pyridoxine-7171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K47467075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73707
tanespimycin-6978	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02636
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902005
tetracaine-7473	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950372
BRD-K65789952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30308
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A907-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88189
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.21501
caudal group of intralaminar nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24541
Charcot-Marie-Tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
K562_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013952
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBC1D10B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42480393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01504
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59045
AP2A1	Pathway Commons Protein-Protein Interactions	1.0	null
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13877
Sarcoma_SARC_TCGA-3B-A9HR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4245
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.995839
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
levonorgestrel-3406	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12782513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71049
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.40282
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.42206
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.605
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
endosomal vesicle fusion	GO Biological Process Annotations 2023	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.71
pharmacogenomic	GAD High Level Gene-Disease Associations	1.0	0.293278
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.896308
regulation of SNARE complex assembly	GO Biological Process Annotations 2025	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.041
BRD-K36324810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62988
BRD-K86104966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08337
propose	GeneRIF Biological Term Annotations	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39945
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.439728
ARAF	Pathway Commons Protein-Protein Interactions	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.481
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894193
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.64125
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15648
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9509
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE226249_2_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.942
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K72721410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48345
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.658074
PLEKHA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K90697692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23733
ajmaline-7484	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K82064887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15731
BRD-K12064774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42281
GSE154464_0_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85235446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13293
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8785
BRD-K82112239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28655
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Platelet dense granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.599
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
IGROV1_OVARY	CCLE Cell Line Proteomics	1.0	5.39182
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
CHD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13992
sensory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.290103
BACH1-22875853-CHIP-PCR-HELA-AND-SCP4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TTI1	Pathway Commons Protein-Protein Interactions	1.0	null
TSC22D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03733
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83614
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4V-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_8484_KO_TET1/TET2/TET3_SRP251780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.09269
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12957
endosome membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
FOSL2	ENCODE Transcription Factor Targets	1.0	null
GTEX-SNOS-1026-SM-4DM4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03773
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29339
integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.365562
White prepupa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.363
blastomere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067356
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915406
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC3568013-1471-2105-13-128-S6.xls-NME2-Unnamed_1_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9316
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Unnamed_9_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
estradiol-6928	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Breast Neoplasms	CTD Gene-Disease Associations	1.0	2.88009
GTEX-U8XE-1726-SM-4E3IF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842954
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19159
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6R0-01A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39571490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31474
PDCD4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CM-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37742
Perturb_4492_KO_Tcf4_SRP072458	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.0384
GTEX-X8HC-0726-SM-46MWG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66451
Dystonia 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
WASH2P	Pathway Commons Protein-Protein Interactions	1.0	null
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RSU1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41322154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20581
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11585
BRD-K36171309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04083
CAB39	Pathway Commons Protein-Protein Interactions	1.0	null
procainamide-4602	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.95406
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14122
GTEX-SIU7-1626-SM-4BRUK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976093
SKMEL30	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88638
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PHLDA2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.TP53.M_24H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2029
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QVJO-1626-SM-2S1QW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896667
GTEX-NL4W-0011-R9a-SM-2I3G1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24105
Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.85353
SKMM2	DepMap CRISPR Gene Dependency	1.0	3.30478
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8165
endosomal transport	GO Biological Process Annotations 2023	1.0	null
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27372445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01035
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.437637
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89592
GTEX-S7SF-1026-SM-4AD4I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827626
GTEX-S4Q7-0226-SM-4AD5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16092
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7222-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44799944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15383
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51068
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46083
Lung squamous cell carcinoma_LUSC_TCGA-58-8393-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.873068
GTEX-X5EB-0726-SM-46MVR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14507
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.833858
RABL2A	Pathway Commons Protein-Protein Interactions	1.0	null
schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.218715
GTEX-XAJ8-0126-SM-47JYG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909174
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.967579
GTEX-S7SF-1626-SM-3K2AY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09823
BRD-K85456600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41842
BRD-K97929312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19367
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33465
BRD-K34282646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15536
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.995779
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30132
COLO 849	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01151
tlp	GeneRIF Biological Term Annotations	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUDHL10	DepMap CRISPR Gene Dependency	1.0	2.88793
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocytic recycling	GO Biological Process Annotations 2025	1.0	null
PECAPJ34CLONEC12	CCLE Cell Line Gene CNV Profiles	1.0	1.40037
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
K562_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173139
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06665
BRD-K20051655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60907
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.916273
Membrane raft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.808
droperidol-1290	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endosomal part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74472
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
35 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.96
UAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Atg12-Atg5-Atg16 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.869
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00268
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1434
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60994
TNIK_knockdown_297_GSE17623	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.21334
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290499
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K62325456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47896
droperidol-2645	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
epididymis	HPA Tissue Protein Expression Profiles	1.0	0.878931
butein-607	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.327956
BRD-K67137502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06586
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dacarbazine-1762	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244698
BRD-K51577368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12785
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2405	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52178
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC38	GDSC Cell Line Gene Expression Profiles	-1.0	-2.04909
BRD-K20073772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22671
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BLOC-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.123
tubocurarine chloride-6351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KHDRBS1	Pathway Commons Protein-Protein Interactions	1.0	null
Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2	InterPro Predicted Protein Domain Annotations	1.0	null
dacarbazine-2754	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SIU8-0626-SM-2XCDN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881902
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.68
ATXN2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18593
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39333
DUSP3	Pathway Commons Protein-Protein Interactions	1.0	null
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17104
tanespimycin-428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.13642
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5159
GSE233183,GSE233187_2_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
ESC_V6.5_UP_EARLY.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Hypophosphatasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
OE-31-YC41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208421
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.999014
balance	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clustering	GeneRIF Biological Term Annotations	1.0	null
esculin-6310	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCOR-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22421
macroautophagy	GO Biological Process Annotations 2023	1.0	null
uterine endometrial cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K59778279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64547
Perturb_5899_KD_CHAF1A_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.82826
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PLIN3	Pathway Commons Protein-Protein Interactions	1.0	null
ERLIN2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Helper T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.246
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859781
CRCGN015_MCF10A.TP53.M_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24705
GSE134316_1_v_0_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.873706
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168702
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OTX2_KO_GDS4440_424_mouse_brain (fourth ventricular choroid plexus)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.929501
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5260-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081252
lycorine-3891	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81913
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71773
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.878931
SYNJ2BP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61821542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07454
protein localization	GO Biological Process Annotations 2015	1.0	null
diethylstilbestrol_mus musculus_gpl6887_gse37969	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
localization	GO Biological Process Annotations 2015	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K90255725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26461
late endosome	GO Cellular Component Annotations 2025	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
hsa-miR-425-5p	MiRTarBase microRNA Targets	1.0	null
Retinitis pigmentosa 56	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
Peribacteroid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.082
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25639
GTEX-SUCS-1926-SM-32PM3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863351
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13522
BRD-K71671197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55038
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227709
ARL5A	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83305
Lung adenocarcinoma_LUAD_TCGA-44-5645-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHLDA3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K78818514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5861
Intracellular vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.57
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22946
GOPC	Pathway Commons Protein-Protein Interactions	1.0	null
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1689
BRD-K31081052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09439
EXOC8	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50001
LY-294002-6945	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturbations to host cell autophagy induced by SARS CoV 2 proteins	WikiPathways Pathways 2024	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.787
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.75452
1349_CCT5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29266
LUDLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.9063
serotonin-5633	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE171572_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bacteroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
mevalolactone-2718	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
K562_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016467
HAUS1	Pathway Commons Protein-Protein Interactions	1.0	null
SNU1272	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39486
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fluvastatin-5290	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tolbutamide-142	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNX12	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K52416366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22943
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47V-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
guaifenesin-3431	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178255_5_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
altering	GeneRIF Biological Term Annotations	1.0	null
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EXOC4	Pathway Commons Protein-Protein Interactions	1.0	null
QE-93-PG25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213791
GTEX-OXRL-0526-SM-2I3EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867928
NAPA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60002
hsa-miR-3200-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
ascospore-type prospore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.129
BRD-K47906308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16847
Infantile hypophosphatasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.594
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
zardaverine-4793	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29634
morula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06839
ketoconazole-5685	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AP2A2	Pathway Commons Protein-Protein Interactions	1.0	null
acacetin-2189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051906
CRCGN016_MCF10A.WT.HP_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17354
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.029
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83032
chlorhexidine-5403	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73C-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.01552
knockdown	GeneRIF Biological Term Annotations	1.0	null
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05484
prazosin-3098	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus	GeneRIF Biological Term Annotations	1.0	null
GSE96057_1_v_2_oma1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocytic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.977
merkel	GeneRIF Biological Term Annotations	1.0	null
NRAS	Pathway Commons Protein-Protein Interactions	1.0	null
Cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.573
ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SF-67-CJ22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248163
BCB000040-7559	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QV31-0126-SM-447BP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998038
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
(+)-chelidonine-1786	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
LYN	Pathway Commons Protein-Protein Interactions	1.0	null
bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.00668
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.28037
GTEX-XAJ8-1426-SM-47JYM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31041
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08579
GTEX-XGQ4-1826-SM-4AT6F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920369
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61868194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18161
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13522
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
repaglinide-6135	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CP in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.941413
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68045
tranylcypromine-2264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.878387
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.02383
contributing	GeneRIF Biological Term Annotations	1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29117
KMS11	DepMap CRISPR Gene Dependency	1.0	2.68147
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AP3D1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_5716_KO_Chaf1b_ERP006640	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.6876
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3371
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2584
TJP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35921
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZW10	Pathway Commons Protein-Protein Interactions	1.0	null
K562_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0292642
GTEX-WH7G-1726-SM-4LVKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94405
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48539
BRD-K40276277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15246
VRK1	Pathway Commons Protein-Protein Interactions	1.0	null
CORL95	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62385
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.925401
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48319
fluvoxamine-7333	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FNBP1L	Pathway Commons Protein-Protein Interactions	1.0	null
vacuolar membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.789649
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.968063
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.9235
A253	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48112
hsa-miR-661	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
erythromycin-1928	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02685
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Retinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
IB-14-XS97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289864
zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065591
butirosin-666	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNX3	Pathway Commons Protein-Protein Interactions	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054664
Ebola virus infection in host	WikiPathways Pathways 2024	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.8305
nucleus-vacuole junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.032
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.077
ESCRT-0 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.426
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9819
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11521
lysosomal membrane	GO Cellular Component Annotations 2015	1.0	null
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.988388
GTEX-T5JC-0011-R9A-SM-32PLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935481
SUM159PT	DepMap CRISPR Gene Dependency	1.0	2.17953
GSE211286_7_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158319
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary endosperm nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.797
WDFY1	Pathway Commons Protein-Protein Interactions	1.0	null
STAT3	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YT-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.969122
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31519
ELF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lysosome	LOCATE Curated Protein Localization Annotations	1.0	null
KIF20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52226
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7592-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHP1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MW-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
angular gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.855483
RERFLCAI	CCLE Cell Line Gene Expression Profiles	-1.0	-2.20864
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE172247,GSE172250_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
STK11_knockout_278_GSE34866	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.2305
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PTK2B	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6739105-aau4139_Table_S5.xlsx-CMC-NR1H2_NR1H2	Rummagene Transcription Factor Associations 2026	1.0	null
SPI1_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endosome	GeneRIF Biological Term Annotations	1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01377768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02455
PMC8047442-EMBJ-40-e105492-s003.xlsx-MR_plot_analysis-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
rab7gtp	GeneRIF Biological Term Annotations	1.0	null
SNX14	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.891235
CLPB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-REY6-0626-SM-2TF4G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45615
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18099
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.08859
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29545
GAPVD1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-769-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64534
BRD-K18888894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74978
BRD-K14394756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23155
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3168
GSE234334,GSE234336_1_v_0_zhx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22856
Idioblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.830002
diclofenac-2756	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CD24_Reduced expression_GDS1392_93_human_Bone Marrow	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NV-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.73725
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.965314
BRD-K69468381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12106
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-0526-SM-2TF5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19524
GTEX-XUJ4-0226-SM-4BOP8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.84751
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
betonicine-3642	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100501_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44297
BRD-K56188606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04187
CRCGN017_MCF10A.WT.HP_24H:G09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14045
Organelle subcompartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.94
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HS766T	DepMap CRISPR Gene Dependency	1.0	3.27542
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE201309_5_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
liver	HPA Tissue Gene Expression Profiles	-1.0	-2.06113
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34097
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.284401
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K02159791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12106
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
prednisone-1897	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K27147269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5464
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1763
MOTN1	CCLE Cell Line Gene Expression Profiles	1.0	1.81494
JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	13.4608
18508997-Table2a	GeneSigDB Published Gene Signatures	1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sw13	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1247
Dsl1/NZR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.587
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.894497
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57013
PMC12486367-Supplementary_Data2.pdf-102-ZNF445_ZNF445	Rummagene Transcription Factor Associations 2026	1.0	null
nortriptyline-7422	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
genistein-6952	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12260399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12742
SNX8	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4LF-0526-SM-3NMB6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7536
EGFR	Pathway Commons Protein-Protein Interactions	1.0	null
Edema	HuGE Navigator Gene-Phenotype Associations	1.0	null
aklomide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27685
BRD-K41643612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08865
Mesothelioma_MESO_TCGA-LK-A4O5-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bepridil-1274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2323
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89492
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37306
Oculocutaneous albinism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951912
BRD-K54922310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0865
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.997032
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
Macropinosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.866
KON	DepMap CRISPR Gene Dependency	1.0	2.16223
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300901
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40724
BRD-K63171151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31194
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75142
Organelle membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.117
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fibroblasts	GeneRIF Biological Term Annotations	1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE223008_7_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT1	Pathway Commons Protein-Protein Interactions	1.0	null
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.65571
LAMP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A59X-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
PIGC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29032
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48012250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7964
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
BRD-K16551475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34625
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
HUH1	CCLE Cell Line Gene CNV Profiles	1.0	1.59764
CSTB_KO_GDS5090_199_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
membrane coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.22385
ES8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OD-96-OP94_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286737
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1537
dioxybenzone-5699	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866985
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.28931
RAB18	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40177
SFT2D2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4954
RAP1A	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bronchioalveolar carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
SGK3	Pathway Commons Protein-Protein Interactions	1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11447
Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46444
BRD-K87385385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13278
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphnode_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.4876
ELP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70598
BRD-K04036799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36618
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20281
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mast cells	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.80794
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Coelomocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.18
CC-03-PW00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438611
BRD-K19040998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32149
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.139222
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
GOLGA7	Pathway Commons Protein-Protein Interactions	1.0	null
VPS37B	Pathway Commons Protein-Protein Interactions	1.0	null
2-deoxy-D-glucose-344	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K38345640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29041
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.457
corvet complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.38738
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100396_HIP_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31477
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.83307
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233679_5_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
Golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.466
CDC42BPB	Pathway Commons Protein-Protein Interactions	1.0	null
Retinoblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
KLC2	Pathway Commons Protein-Protein Interactions	1.0	null
Outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.915
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09161
Lung adenocarcinoma_LUAD_TCGA-55-8206-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
AB-00-IL62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200036
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91747
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
fluorocurarine-6219	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
c-Ets-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Phagophore assembly site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.633
endosomes	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A6UM-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7468-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
alverine-6345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.094256
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5763
PRKAR2A	Pathway Commons Protein-Protein Interactions	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
16484322-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
isoetarine-7170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26368
bromperidol-7457	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH1395	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50859
SKNFI	CCLE Cell Line Gene CNV Profiles	1.0	1.8176
NCIH2347	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46073
SKMM2	CCLE Cell Line Gene Expression Profiles	1.0	1.65394
ARF6	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-WY-A85C-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
COPZ1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3128	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498503
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KMS-11/TKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
Acute Myeloid Leukemia_LAML_TCGA-AB-2882-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44549496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24017
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K17199106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13278
GSE119564_2_v_0_zfp217_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7306-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H5-01B-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BLOC-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.53
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K22591777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17227
BRD-K74537725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0106
intracellular protein transport	GO Biological Process Annotations 2015	1.0	null
VPS51	Pathway Commons Protein-Protein Interactions	1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.78623
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RAB7A	Pathway Commons Protein-Protein Interactions	1.0	null
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08609
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897777
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USP9X	Pathway Commons Protein-Protein Interactions	1.0	null
COPE	Pathway Commons Protein-Protein Interactions	1.0	null
Mucolipidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
PMC11947124-41419_2025_7562_MOESM1_ESM.docx-347-ENSG00000151500_THYN1	Rummagene Transcription Factor Associations 2026	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
VPS33B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.60973
RBX1	Pathway Commons Protein-Protein Interactions	1.0	null
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16933
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Extrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.538
HOPX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00846
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.395
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60044070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07902
Lysosomal HOPS complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.97649
AP2B1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Clathrin, heavy chain/VPS, 7-fold repeat	InterPro Predicted Protein Domain Annotations	1.0	null
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
Mucocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.109
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9134
HCC2157	CCLE Cell Line Gene Expression Profiles	-1.0	-2.01044
SARS-CoV-2 modulates autophagy	Reactome Pathways 2024	1.0	null
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BCPAP	CCLE Cell Line Gene Expression Profiles	1.0	2.91978
K562_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01854
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K74056311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18096
CORVET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.318
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63809385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08429
HAUS3	Pathway Commons Protein-Protein Interactions	1.0	null
Atg1/ULK1 kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.688
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DAUDI	CCLE Cell Line Gene CNV Profiles	-1.0	-2.25566
JUND	ENCODE Transcription Factor Targets	1.0	null
GTEX-XPVG-0626-SM-4B65B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35259
POLR2AphosphoS2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A6RC-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.885377
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
18787207-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X8-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JHH7	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78877
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.858112
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.947689
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29685
BRD-K98601267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33638
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATOR2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.845
trans-Golgi network membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.947
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37404
BRD-K38519440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5174
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.988344
SUPT11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50073
Ebola hemorrhagic fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
Prestwick-1082-7027	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13522
Lung adenocarcinoma_LUAD_TCGA-55-6975-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35384
Phagocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.794
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer SZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888267
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CDC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33626
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STX3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60272064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25385
NTRK2_drugactivation_66_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.00794
hsa-miR-532-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
DB-56-XL71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375734
GET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.588
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76435
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24981
GSE191015_0_v_2_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18835
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZUP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04732
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.16545
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19666
isoniazid-1399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.99996
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42013
pivampicillin-5465	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DYNLRB1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-330-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
lysosomal transport	GO Biological Process Annotations 2025	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JA-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46936
MCF7_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161375
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.65017
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE228413_2_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20634
lymphnode_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.943295
RALA	Pathway Commons Protein-Protein Interactions	1.0	null
CD4_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.84471
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189652
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386748
BRD-K93806272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38203
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
QGP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_5952_KD_RBM15_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.19444
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TM9SF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21809
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
TNK1	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
miR-targeted genes in leukocytes - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paw	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.576
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.969087
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25787
pirlindole-5497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27385
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAPPI protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.171
rofecoxib-371	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOX2-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE140651,GSE140653_3_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14875480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2232
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35355
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.848357
Clathrin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.694
PACSIN2	Pathway Commons Protein-Protein Interactions	1.0	null
CKAP5	Pathway Commons Protein-Protein Interactions	1.0	null
sodium phenylbutyrate-407	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NEDD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0826
thyroid	GTEx Tissue Gene Expression Profiles	1.0	0.908809
GTEX-PWN1-2626-SM-2I3FH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26628
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054864
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43238
debrisoquin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37974
fulvestrant-7096	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-POYW-1326-SM-48TCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999242
CALU6_LUNG	CCLE Cell Line Proteomics	1.0	2.64021
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13877
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81916
Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66156
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14206
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ADRM1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188757
SW1990	CCLE Cell Line Gene Expression Profiles	-1.0	-1.86963
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prednisolone-7424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LK-01A-12R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15724
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21264
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
prazosin-5416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K53634892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32271
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.578
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.869743
Lung adenocarcinoma_LUAD_TCGA-55-6980-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
clathrin-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.259
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0641
VIPAS39	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58033
Barrett Esophagus_Esophageal Tissue_GSE1420	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.50185
hesperetin-5350	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.593
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45262
l45	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
STAT5A	ENCODE Transcription Factor Targets	1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.862216
Endoplasmic reticulum protein-containing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.882
94T778	DepMap CRISPR Gene Dependency	1.0	2.68397
regulate	GeneRIF Biological Term Annotations	1.0	null
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058727
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A07952294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27555
VPS26A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.889929
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DCTN2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205568
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41427
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
AICDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50393
Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CRCGN015_MCF10A_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64323
ARL6IP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16502264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66109
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
hsa-miR-3925-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45023
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02791
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVTOKO	CCLE Cell Line Gene Expression Profiles	-1.0	-2.19253
BRD-A75087829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79551
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UJHI-0726-SM-3DB92	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99152
moxisylyte-7015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NuA3b histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.543
plant-type vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.199993
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
vacuole	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K36782804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34766
Lung squamous cell carcinoma_LUSC_TCGA-58-8388-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0126-SM-2XCBB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46451
RINT1	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1419	DepMap CRISPR Gene Dependency	1.0	2.84317
GSE182680,GSE182683_10_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
clathrin coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.256561
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARHGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8166
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
tridihexethyl-5486	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PITPNA	Pathway Commons Protein-Protein Interactions	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34302
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.684965
SNAP29	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50568
CRCGN015_MCF10A_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36165
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056831
lysosomal membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Prostate adenocarcinoma_PRAD_TCGA-HC-8261-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH647_LUNG	CCLE Cell Line Proteomics	1.0	2.67703
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.25322
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21225
Amphisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.063
specificity	GeneRIF Biological Term Annotations	1.0	null
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162403
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LZ-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35094
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42048
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.897638
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.29937
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4571
Lytic vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.236
PC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31299
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05116
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.412
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.533081
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29286
GTEX-X261-3226-SM-3NMC3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860454
STX12	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
DOCK5	Pathway Commons Protein-Protein Interactions	1.0	null
PCYOX1	Pathway Commons Protein-Protein Interactions	1.0	null
RHOF	Pathway Commons Protein-Protein Interactions	1.0	null
CP67-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
fenoprofen-2553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.66715
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840001
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
pargyline-7016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227363
LPXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06169
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01285236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04188
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175384
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
rosiglitazone-5593	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13815
phenyl biguanide-22	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
proxymetacaine-3113	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
OXSR1	Pathway Commons Protein-Protein Interactions	1.0	null
copper sulfate-459	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SKNAS_AUTONOMIC_GANGLIA	CCLE Cell Line Proteomics	1.0	2.23529
CRCGN013_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22195
GSE230263,GSE230265_0_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ESCRT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.849
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Phosphatidylinositol 3-kinase complex, class II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
STAT5B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K15742845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87671
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HOXC9	ChEA Transcription Factor Targets	1.0	null
VM-CUB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20002
Perturb_7671_KD_NBAS_SRP267245	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.75055
vestibular nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.985407
BRD-K39705203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47973
translocating	GeneRIF Biological Term Annotations	1.0	null
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7870-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02918
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826107
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YV-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
tinidazole-3430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_2-Methoxyestradiol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120657
embryonic lethality between implantation and somite formation, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
4116_INCENP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24406
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896476
BRD-K96758498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34167
MAPK14	Pathway Commons Protein-Protein Interactions	1.0	null
CPLX1	Pathway Commons Protein-Protein Interactions	1.0	null
Golgi apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.036
novobiocin-342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.894498
COLO818	CCLE Cell Line Gene CNV Profiles	1.0	1.50119
RAB8A	Pathway Commons Protein-Protein Interactions	1.0	null
Hermanski-Pudlak Syndrome	DisGeNET Gene-Disease Associations	1.0	null
NCIH2347	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73805
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3616-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
GSE158431_2_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15714104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03733
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36204
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05357
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.884689
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12957
impairs	GeneRIF Biological Term Annotations	1.0	null
MKN45	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65178
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40836
SNAP23	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4343-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
regulation of protein-containing complex assembly	GO Biological Process Annotations 2023	1.0	null
mercaptopurine-667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_5895_KD_CCDC137_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.14581
RB1_KD_GSE50532_627_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
K562_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152206
Perinuclear endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.998
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.41781
ZNF143	ENCODE Transcription Factor Targets	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10603
ALS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48711
BRD-K41287744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61003
Amino acid transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.688
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-21-BF25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446699
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10714
budesonide-2866	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thiamphenicol-glycinate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08632
BRD-K11757577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99715
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0519
496100532_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37059
Endoplasmic reticulum exit site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.948
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF542P	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98667
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37503
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U4B1-0526-SM-4DXTK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926699
famotidine-6665	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1	ChEA Transcription Factor Targets	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MF-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.01663
MOLT13	CCLE Cell Line Gene Expression Profiles	1.0	1.44758
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K36382446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83721
CRCGN017_MCF10A.WT.HP_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0084
GSE160817_4_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37668
GSE171724_1_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARH77	DepMap CRISPR Gene Dependency	1.0	2.21861
skmel30	HPA Cell Line Gene Expression Profiles	-1.0	-0.934876
isoconazole-1372	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.454816
BRD-K20829034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13671
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MVP	Pathway Commons Protein-Protein Interactions	1.0	null
MIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77933
MYC	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981547
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.923781
AH-23848-6903	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939412
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KASUMI1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57156
Lung adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.157
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2333
Rectum adenocarcinoma_READ_TCGA-AG-3591-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
MCF7_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131243
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_17_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251689
GTEX-X5EB-1826-SM-4E3K8	GTEx Tissue Sample Gene Expression Profiles	1.0	3.62438
Lytic vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.588
4-hydroxyphenazone-1915	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
YIF1A	Pathway Commons Protein-Protein Interactions	1.0	null
autophagosome-lysosome fusion	GO Biological Process Annotations 2025	1.0	null
Hemolymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K36me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ctnnb1_21565795_adrenocortical_adenomas_lof_mouse_gpl570_gds3912	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.052633
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974047
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26567
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36272
tetraethylenepentamine-457	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
15297395-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE135350_2_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
GTEX-XPVG-2126-SM-4B667	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0039
benzydamine-7169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MDA-MB-415	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4866-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963594
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.34469
BORC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.816
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BLOC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.737
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sisomicin-2853	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240056
HEV_60Day_None_GSE53731	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.25803
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MCF7_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153787
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
demeclocycline-2545	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HT55	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374524
BRD-K10171338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.24453
isocorydine-1787	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.923
GTEX-P4QS-2026-SM-3NMCG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15855
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUH6	DepMap CRISPR Gene Dependency	1.0	3.08656
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-IRF6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64817
RBL-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.846
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K31666794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25417
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.969122
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268406
BNIP1	Pathway Commons Protein-Protein Interactions	1.0	null
SEPT7	Pathway Commons Protein-Protein Interactions	1.0	null
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.0244
Cvt vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.148
MAPK1	Pathway Commons Protein-Protein Interactions	1.0	null
SCAMP3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZI-1026-SM-3NB1K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50166
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69836
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.974864
BRD-K67531128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30538
transcriptional	GeneRIF Biological Term Annotations	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COPB2	Pathway Commons Protein-Protein Interactions	1.0	null
Vacuolar membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD4+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.90856
cingulate gyrus, parietal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.825982
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36708
hsa-miR-4663	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BRD-K85823016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3803
iloprost-488	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YKT6	Pathway Commons Protein-Protein Interactions	1.0	null
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
Cell cortex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.653
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
GTEX-S95S-1226-SM-4GICG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824225
TUBGCP2	Pathway Commons Protein-Protein Interactions	1.0	null
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
caffeic acid-5352	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156357
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_7_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JY-01A-31R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27092365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23816
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6477-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWO3-0011-R1A-SM-2I5EW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846628
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ALG10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06858
CAS1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61308
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09064
amiprilose-3339	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47164766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45938
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.39599
CDK5	Pathway Commons Protein-Protein Interactions	1.0	null
MZ in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.857646
ROCK_INHIBITION_GDS3944_462_mouse_Forebrain astrocytes - 6 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.900043
BIN1	Pathway Commons Protein-Protein Interactions	1.0	null
DYNC1LI2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1395	GDSC Cell Line Gene Expression Profiles	-1.0	-1.68886
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-7848-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.951919
outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.130423
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2521
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5096
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.258745
erastin-6412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LF-35-CP32_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.591726
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.694946
RHOA	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5390115-mmc7.xlsx-DE_Lists-H1-ECs_Experiment_2_H1-EC2_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBE3A_KD_significant-Unnamed_23_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SNX9	Pathway Commons Protein-Protein Interactions	1.0	null
RPMI-2650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32666
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60582
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.53805
benzethonium chloride-7207	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAPK8	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16291
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085824
MM386	DepMap CRISPR Gene Dependency	1.0	2.40785
acenocoumarol-1394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
germ tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.385822
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.862216
ELMO3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8947
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4924
KDM4A	ENCODE Transcription Factor Targets	1.0	null
GTEX-WYVS-2126-SM-3NMA3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3013
SOX2	ChEA Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40687
budesonide-1716	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894825
exisulind-309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27578
BRD-K96417480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07483
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179880_10_v_13_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Melanosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.217
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.893991
Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1	InterPro Predicted Protein Domain Annotations	1.0	null
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0273
LN215	CCLE Cell Line Gene Expression Profiles	1.0	1.47273
HCFC1	ENCODE Transcription Factor Targets	1.0	null
Sorting endosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.943
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29779
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.6959
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Trolox C-1734	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
embryonic lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K22748970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50633
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26591
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.63966
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.91072
Generalized dystonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
AMO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
smad4	GeneRIF Biological Term Annotations	1.0	null
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
nuc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tuberomammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.099
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09357
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tuberous sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CerebellumPeduncles	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.23823
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63672
bounding membrane of organelle	GO Cellular Component Annotations 2023	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26044
BRD-K17765399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36967
lidocaine-1499	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE226249_2_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FLII	Pathway Commons Protein-Protein Interactions	1.0	null
SLC30A9	Pathway Commons Protein-Protein Interactions	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053051
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0016
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207529
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.892656
CAL-12T	GDSC Cell Line Gene Expression Profiles	1.0	1.67087
RAB3GAP2	Pathway Commons Protein-Protein Interactions	1.0	null
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Myotonic dystrophy type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
GI-1	GDSC Cell Line Gene Expression Profiles	1.0	1.98631
XPO7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.44465
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-758	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.50893
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-2126-SM-3NB2R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1373
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JK-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BLOC1S4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	1.0	0.842853
MCF7_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122074
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32882
Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.320227
chediak-higashi syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.09755
vacuole-mitochondrion membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.248
EE-02-BO83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224259
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.977246
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48456
BRD-K80413110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12805
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MHH-PREB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2499
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.41066
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mv1lu	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.52
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9434
SRF	ENCODE Transcription Factor Targets	1.0	null
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
modulator	GeneRIF Biological Term Annotations	1.0	null
BRD-K61072684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31049
NUP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42656
CALR	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SEC61G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29087
GTEX-WYVS-1626-SM-3NM9R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951003
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43X-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01049
SEPT11	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.852665
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241032
MM426	DepMap CRISPR Gene Dependency	1.0	2.39383
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
endosomal vesicle fusion	GO Biological Process Annotations 2025	1.0	null
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K46322281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06304
SLC16A7+ cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE249146_2_v_3_dusp6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.78028
Adrenocortical carcinoma_ACC_TCGA-OR-A5K9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPK-1326-SM-3MJGN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94221
PTK2	Pathway Commons Protein-Protein Interactions	1.0	null
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062029
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54E-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
4957_MED7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07138
dexpanthenol-1680	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Secondary lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.135
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EU-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U2-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.118
STAT3	ENCODE Transcription Factor Targets	1.0	null
BRD-K69521416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27375
dependence	GeneRIF Biological Term Annotations	1.0	null
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8983
NEK9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38485
BRD-K02337960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6737
hsa-miR-4504	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.833046
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K24170552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50894
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.97721
PL18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RRAS	Pathway Commons Protein-Protein Interactions	1.0	null
thiocolchicoside-5520	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5442
SCYL1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SRY	ChEA Transcription Factor Targets	1.0	null
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.452427
BRD-A17658676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01245
BRD-K43969492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55736
BRD-K59535072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27433
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-1426-SM-2S1OQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47556
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02808
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU1J-0326-SM-46MUM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89026
ergocalciferol-5346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU8	DepMap CRISPR Gene Dependency	1.0	3.29889
BRD-K61681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16229
BRD-K11581306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25287
BRD-K89089981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17741
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166253
PGAM5	Pathway Commons Protein-Protein Interactions	1.0	null
Eyespot apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.517
EPB41L5	Pathway Commons Protein-Protein Interactions	1.0	null
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.32497
MVB12A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K27472340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03336
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34487
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055647
GTEX-VJYA-0726-SM-4KL1T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826426
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6131-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-IK-7675-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK2_knockdown_90_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.22241
Acute Myeloid Leukemia_LAML_TCGA-AB-2819-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
spleen	GTEx Tissue Gene Expression Profiles	1.0	1.10632
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34446
Vacuolar membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.543
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC366	CCLE Cell Line Gene CNV Profiles	-1.0	-3.1275
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0839
SKMEL30	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32994
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9316
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78907463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42921
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24116
SNX2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K97276563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84233
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09715
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Invertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
streptozocin-7193	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dexamethasone-123	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21774
Phosphatidylinositol 3-kinase complex, class III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.58
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.67255
vinblastine-7556	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K63908919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04057
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K35587518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1999
MCF7_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143793
H3K9me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03024
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.99725
GSE223008_7_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02438
Martsolf syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47211
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.843242
Perturb_5918_KD_HP1BP3_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.68215
PRKAA1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-575	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
ETV5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45474
hsa-miR-320d	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0809
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872903
ciprofibrate-3561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GINS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49482
LANCL1	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH82	DepMap CRISPR Gene Dependency	1.0	2.15617
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57997
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.993012
Breast_Myoepithelial_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.850535
KLC1	Pathway Commons Protein-Protein Interactions	1.0	null
felodipine-337	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-55-XA97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.635392
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18487
BRD-K24930745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14874
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clemastine-7485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05305
BRD-K45978015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34852
rab7gap	GeneRIF Biological Term Annotations	1.0	null
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
RUNX3	ENCODE Transcription Factor Targets	1.0	null
GNAQ	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53052
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985141
Sarcoma_SARC_TCGA-IF-A4AJ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GOLIM4	Pathway Commons Protein-Protein Interactions	1.0	null
tolnaftate-2001	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SSP25	DepMap CRISPR Gene Dependency	1.0	3.00123
Ciliary vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
Ventilator-associated lung injury_Lung Tissue_GSE2411	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.07975
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ketotifen-1583	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BC-1	GDSC Cell Line Gene Expression Profiles	1.0	2.43948
GSE159206_1_v_3_drd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K24711162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65433
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U412-2026-SM-4DXSI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04196
MXI1	ENCODE Transcription Factor Targets	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.021
GLRX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35332
alimemazine-3478	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27463
Perturb_5927_KD_LTBP2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.83966
SCAMP4	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-IH-A3EA-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
esr1_21299862_mcf7_lof_human_gpl570_gds4065	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.034872
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61642
15297395-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
miR-targeted genes in muscle cell - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
AP-type membrane coat adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.322
BRD-K45732260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06813
K562_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173891
HGS	Pathway Commons Protein-Protein Interactions	1.0	null
BAIAP2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K51681402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50365
Schizont	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9316
LEMD3	Pathway Commons Protein-Protein Interactions	1.0	null
HIP1R	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K79777851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05143
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875652
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5361-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL120	DepMap CRISPR Gene Dependency	1.0	2.16596
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE151612_0_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
18689800-TableS5	GeneSigDB Published Gene Signatures	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9316
GTEX-U8XE-0626-SM-3DB8U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986904
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QCQG-1726-SM-3GIJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93899
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.454387
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00242
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22691
Class C VPS/HOPS complex	CORUM Protein Complexes	1.0	null
PMF1	Pathway Commons Protein-Protein Interactions	1.0	null
zaprinast-3226	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GATOR1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.966
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3357
CRCGN015_MCF10A_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5384
BRD-K89336453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1733
GTEX-OXRL-0126-SM-2YUMP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52367
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14139
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
VPS11	Pathway Commons Protein-Protein Interactions	1.0	null
Vesicle tethering complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.242
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.355
Mon1-Ccz1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.566
GB-46-CK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.662271
mephenesin-7374	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
epitiostanol-4788	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16007
BRD-K97938633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86079
GTEX-V1D1-1926-SM-4JBGX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868982
tet1_21295276_mesc_v6.5_lof_mouse_gpl6887_gse26900	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.176127
pridinol-3456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AF-76-FL46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345485
capan2	HPA Cell Line Gene Expression Profiles	-1.0	-1.05113
BRD-K63573625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27552
SMC3	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chediak-Higashi Syndrome	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PSEN1	Pathway Commons Protein-Protein Interactions	1.0	null
smad2	GeneRIF Biological Term Annotations	1.0	null
TBC1D15	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.925877
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
ATP5PD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08071
COG4	Pathway Commons Protein-Protein Interactions	1.0	null
lincomycin-7411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PDS5B	Pathway Commons Protein-Protein Interactions	1.0	null