association	dataset	threshold value	standardized value
Sensory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
EXOSC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27937
Edema	CTD Gene-Disease Associations	1.0	1.08904
GSE216043_11_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39718
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.41261
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
17297478-SuppTable5	GeneSigDB Published Gene Signatures	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
SNX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.37044
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.9691
PMC9630632-Table1.XLSX-diff_exp_genes-Group_1_vs_2_AND_Group_2_vs_3_NOT_Group_1_vs_3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
MYRFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.0212
UQCRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33537
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43001
CALU-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20579
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.80858
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
DCAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69402
acrosomal vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.636295
GSE162590_1_v_0_gsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mRNA_SOX2_17515932	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
C10orf105	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16847
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.606
positive regulation of white fat cell proliferation	GO Biological Process Annotations 2023	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	4.36964
Retinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
hsa-miR-4438	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
regulation of lipid storage	GO Biological Process Annotations 2023	1.0	null
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19619
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE223008_7_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100316_5_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30541
GSE130864_0_v_1_tincr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80993
CAMTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47582
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
medial septal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.834188
UBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95242
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.846156
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53033
PRADC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32698
REST_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Immunoglobulin subtype	InterPro Predicted Protein Domain Annotations	1.0	null
ESRRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.41459
ZNF513	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56502
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0188
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.625
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.324
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mandibular incisor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.144
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectal adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.927
THAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71039
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYNCRIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65202
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CDX2_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22408
Perturb_8602_KO_Mir132_SRP064164	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.61421
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.05864
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74601
AP1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20651
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.39404
CHAGO-K-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.914602
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.21495
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61156
brain	GTEx Tissue Gene Expression Profiles	1.0	2.17685
UBALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17344
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1255
small kidney	IMPC Knockout Mouse Phenotypes	1.0	null
SYT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.8566
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.061879
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.867405
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11036
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05069
PIAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11309
Henles loop	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
BICR16	DepMap CRISPR Gene Dependency	1.0	2.70544
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
STRADB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05076
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.991554
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00862
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SDF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42023
DLAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04089
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.56085
SMIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50085
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.993403
Mucinous Tubular And Spindle Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Ebolavirus(ZEBOV)_5day_Liver_None_GSE57214	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.85863
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34115
hsa-miR-432	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83052
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.967557
SUM52PE	DepMap CRISPR Gene Dependency	1.0	2.94042
MRPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4796
DLGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16319
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.87823
SNU1544	DepMap CRISPR Gene Dependency	1.0	2.26826
GINS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97259
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.836197
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901703
Lung adenocarcinoma_LUAD_TCGA-44-2661-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEFF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5636
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lingual gyrus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70644
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07116
TPGS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13199
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.68158
lateral septal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11245
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6999
HCC-15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
Rectum adenocarcinoma_READ_TCGA-AG-3731-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.826084
C15orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.092
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81I-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04527
RIOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4741
SYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15752
SUZ12	ENCODE Transcription Factor Targets	1.0	null
CCT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16193
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.902444
NZM42	DepMap CRISPR Gene Dependency	1.0	3.42487
MYF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17876
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8054-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24658
RAB11FIP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01014
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1633
outer SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.949367
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KYSE-410	COSMIC Cell Line Gene Mutation Profiles	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NAA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14553
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946698
VDAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58477
CHMP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45458
GTEX-QDT8-0011-R6A-SM-32PKI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08187
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67865
DOHH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53176
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81N-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NAA20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25399
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular response to growth factor stimulus	GO Biological Process Annotations 2023	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.863498
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24623
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43019
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3761
KIF26A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1466
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975814
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917065
hESC Derived CD184+ Endoderm Cultured Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.919958
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0504
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14599
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU475	DepMap CRISPR Gene Dependency	1.0	2.27662
ZMYND8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13481
CAL-12T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE146865,GSE146866_4_v_3_saracatinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cellular response to BMP stimulus	GO Biological Process Annotations 2025	1.0	null
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37149
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7658
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.44341
LUDLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.70957
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IF-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Collecting duct carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.564
NRL_Deficiency_GDS1693_239_mouse_Photoreceptors cells of retinas at 4 weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73171
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49409
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5012
CHST7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.87615
COX8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07155
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11589
positive regulation of white fat cell proliferation	GO Biological Process Annotations 2025	1.0	null
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1739
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
APBB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98765
TMPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4771
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.898991
Heschl's gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0468
GSE210655_3_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9435
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928738
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084829
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.84462
CACNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86941
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	2.37693
ZNF575	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29915
ONECUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35064
SEM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74203
CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_766_mouse_Skin - 0 Day	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_146_KD_Mettl3_SRP033779	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.76315
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
Perturb_12556_KO_Sirt6_SRP302465	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.77231
PACS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06337
HLA-DRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44384
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21126
A-VN-1203-2004(H5N1)_Day7-10^2pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.75057
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21143
ETFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31577
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.113
MLL3/4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.128
A-VN-1203-2004(H5N1)_Day7-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.1751
GOLGA6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41229
KPNA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0376
OVOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42741
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1661
DCAF4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51116
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46825
Cardiac Failure_Myocardial tissue_GSE1988	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.44944
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NUDT18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79543
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.924219
EEF1AKMT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88869
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924371
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25669
Perturb_8355_KO_ZCCHC4_SRP345783	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.5187
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.83503
H3K27me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ARNT-22903824-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.96583
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.68682
KDM5A	ENCODE Transcription Factor Targets	1.0	null
temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CAB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64735
PL18	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
H4K20me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0011-R5A-SM-2XCAD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01416
ChIP_H3K9me3_19884255_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86407
SDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08433
GSE100102_4_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSPH deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.022
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-A6W5-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COQ6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9681
ORC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92685
AGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34029
basal nucleus of Meynert	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00213
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980993
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32181
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
Proteinuria	CTD Gene-Disease Associations	1.0	1.18391
CTNNB1_Inactivation_GDS2984_628_mouse_Intestinal crypts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34542
HOXB8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4781
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	111.583
PMC2702100-pgen.1000564.s005.xls-DBP_controls_1e-04-closest_gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6827-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30952
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.633886
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_2day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.7319
KAT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1603
SMCHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95653
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62401
RDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5745
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RAPGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68867
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CLASRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93361
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NAGLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36238
Bladder-myofibroblast cell	Tabula Sapiens Gene-Cell Associations	1.0	1.83006
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of macromolecule metabolic process	GO Biological Process Annotations 2023	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02416
BC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3667
MEPCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44463
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.921162
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TE-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
SLC44A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26527
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.3345
TGF-beta_OE_GDS2974_137_mouse_corneas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11861
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03086
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.855772
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20321
FOXE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39085
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A42Y-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07009
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEIS1_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863811
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF254_01_127	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59988
spleen	GTEx Tissue Gene Expression Profiles	-1.0	-1.2808
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898417
RTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13045
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00213
KASUMI2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7927
REST_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9701
SW872	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TRMT61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00914
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6425
RAB39B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86868
G0S2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30907
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2065
Perturb_124_KD_Tcf7l2_SRP100171	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.60493
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42887
E2F2_KD_GDS4094_447_mouse_Mammary tumors (Myc-induced)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RNF2	ChEA Transcription Factor Targets	1.0	null
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88936
MDA-MB-468	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
Perturb_8647_KO_GATA4_SRP287180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.1653
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.28438
RPL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73105
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.63638
Colo-205 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
REST_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.1908
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14572
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78003
KYSE520	CCLE Cell Line Gene CNV Profiles	1.0	2.74894
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954199
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Eye degenerative disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
SUZ12	ChEA Transcription Factor Targets	1.0	null
LMNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25907
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_SOX6_TrsFib_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.627
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09256
Sarcomatoid carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.038
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2607
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Control_only_up-regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_5387_KO_Isl1_SRP380182	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.837956
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64216
CORO1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32936
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.54466
CCNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.76399
Sebum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
REST_Panc1_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prostate_a	HPA Tissue Sample Gene Expression Profiles	1.0	0.873504
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3689b	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
response to BMP	GO Biological Process Annotations 2025	1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.829821
JHUEM1	DepMap CRISPR Gene Dependency	1.0	4.14987
GSE234289_5_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214382,GSE214383_4_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Y-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MET_knockout_261_GSE8747	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.66397
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26905
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
PMC6668037-NIHMS1530019-supplement-3.xlsx-AR_differential_binding-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03702
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913653
HCC202	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
B3GNT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00777
REST_01_211	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60405
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.16227
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27446
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.999562
MZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.859035
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.960914
GTEX-QMR6-0011-R2A-SM-32PKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82708
HMGB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59602
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03407
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7405
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26597
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898953
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.887537
LRFN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51812
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61361
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3268
ZNHIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32094
MTF2	ChEA Transcription Factor Targets	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02737
disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.126165
EIF4EBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78116
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828782
positive regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2025	1.0	null
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02681
D423MG	DepMap CRISPR Gene Dependency	1.0	2.73617
GSE113734_3_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77541
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93617
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
MSI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45606
CDK17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.825
recurrent bacterial infections	GWASdb SNP-Phenotype Associations	1.0	0.38641
SK-OV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10336
GLUL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22583
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19662
AARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50495
TGFBR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36569
MED29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9212
Wnt-Frizzled-LRP5/6 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58952
TRMT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49963
PXMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01452
MYCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0235
MDAMB436	DepMap CRISPR Gene Dependency	1.0	2.83569
ZNF143	ENCODE Transcription Factor Targets	1.0	null
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926558
regulation of brown fat cell differentiation	GO Biological Process Annotations 2023	1.0	null
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1037
HOXB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94011
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03891
MED26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64917
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A388	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
UBE2D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31167
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.247
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5293
CEMIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81972
GATB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72717
REST_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6166
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Immunoglobulin-like fold	InterPro Predicted Protein Domain Annotations	1.0	null
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3432
Inflammation	CTD Gene-Disease Associations	1.0	1.04314
TMEM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61246
TSFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21196
GTEX-S7SE-0011-R1A-SM-2XCDE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846278
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45027
PMC11669572-CNS-30-e70185-s001.xlsx-Supplementary_Table_4-Supplementary_Table_4_Results_of_MR_analysis_for_causal_effects_of_genes_on_glioma_outcomes_at_the_brain_cell_level_significant_association_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221077_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24311
SELENOV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8657
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.47151
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58472
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.73284
TET1	ChEA Transcription Factor Targets	1.0	null
GSE217363_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTSZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68006
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18228
PKBalpha_KO_GDS1784_196_mouse_Embryonic fibroblasts (MEFs) - 24h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HBQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02722
BMI1	ChEA Transcription Factor Targets	1.0	null
ERBIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62391
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12609
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NB-80-IM48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272441
BCL11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63618
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HSC-3	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
Perturb_14211_KO_Sp8/Sp9_SRP084329	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
NRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94735
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-61	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
Perturb_820_OE_Rspo1_SRP325709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.9698
TXNIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36776
TP63	ChEA Transcription Factor Targets	1.0	null
C6orf120	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31818
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07582
NCI-H1568	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144115_4_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5624885-41537_2017_33_MOESM1_ESM.xlsx-SIT1-SIT1_Top_500_differentially_expressed_genes_with_perturbations_in_CNTNAP2_carrier_NGN2-neurons_using_DESeq2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.569622
SKOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60707
Mesothelioma_MESO_TCGA-MQ-A6BS-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SERINC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59355
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71678
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70568
ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.053896
positive regulation of lipid localization	GO Biological Process Annotations 2023	1.0	null
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WL-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.351
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62454
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0855
RP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58418
ZNF610	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44176
SKCO1	CCLE Cell Line Gene CNV Profiles	1.0	1.34865
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18933
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16863
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09028
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10186
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25956
TUBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13382
REST_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6965
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33662
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WVLH-0011-R7A-SM-3MJFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828996
GSE155031_6_v_7_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23208
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
planum temporale, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.899724
ZNF646	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71735
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.54348
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OVCA420	DepMap CRISPR Gene Dependency	1.0	2.21274
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PFDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.33386
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
REST_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4432-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SLC29A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52274
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.857589
MAPKAPK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6722
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular response to BMP stimulus	GO Biological Process Annotations 2023	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79404
Perturb_131_OE_LSD1_SRP029985	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.3973
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855227
SOCS3_DELETION_GDS1254_80_mouse_ES (embryonic stems cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-5654-11A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HAUS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48106
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41754
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55228
DYNC1H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67025
GSE199606_3_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50888
Leiomyomatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
SRP72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41333
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-EVX1_EVX1	Rummagene Transcription Factor Associations 2026	1.0	null
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.54618
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02714
NCI-H1838	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
AUNIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3116
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Renal adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28785
recurrent infections	GWASdb SNP-Phenotype Associations	1.0	0.30398
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SOX13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4036
18338247-SuppTable4A	GeneSigDB Published Gene Signatures	1.0	null
LYRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59958
SLC12A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70302
REST_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15424
GSE249714_0_v_1_anxa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25677
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31549
USP35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37649
CDX2-21402776-INTESTINAL-VILLUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
YTHDF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69971
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66779
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947277
SEMA3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54402
colon	HPA Tissue Protein Expression Profiles	1.0	1.08756
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.905761
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5748
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ORC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67655
Neuroendocrine cell_Trachea_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
CORL105	DepMap CRISPR Gene Dependency	1.0	3.90355
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.041
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.302
Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLII	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16954
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16166618-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
eye hemorrhage	IMPC Knockout Mouse Phenotypes	1.0	null
NAMALWA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19634
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
GNRH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37949
MEIS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56183
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.950888
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2478
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Emphysema annual change measurement in smokers (percent low attenuation area)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
SKMEL19	DepMap CRISPR Gene Dependency	1.0	8.80343
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2664
KYSE-180	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
GPX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59852
HS852T	DepMap CRISPR Gene Dependency	1.0	8.83938
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
STAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54043
HSPB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00063
JHUEM3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64353
AMIGO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45537
PSMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41459
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TWF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6385
ITPRID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19471
PRICKLE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45007
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2143
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.32672
Autosomal dominant disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421548
Bmi1_Deficiency_GDS4816_323_mouse_Primary lung cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OSBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43868
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27789
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6469
FLI1	ChEA Transcription Factor Targets	1.0	null
PNPLA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38109
AHR-22903824-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Invertebrate mandible	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.127
TEAD4	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A510-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GATA3-21867929-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.18182
positive regulation of lipid storage	GO Biological Process Annotations 2025	1.0	null
CHTF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48566
CTNNB1_OE_GDS4449_352_mouse_Embryonic kidney from E12.5 embryos (-catGOF-UB mutant)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
DCUN1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71794
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08856
Logical memory (immediate recall) in Alzheimer's disease dementia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.709691
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10956
EZH2	ENCODE Transcription Factor Targets	1.0	null
RKO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.996086
CHST13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6506
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77591
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03029
Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.54186
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.852894
LEMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35496
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.89415
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sperm part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.110953
MTHFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89327
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11735
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBE2V2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3726
primary auditory cortex (core)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48629
BMI1-23680149-NPCS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A6B9-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.31691
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Ankylosing Spondylitides_macrophage_GSE11886	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.65304
PPP2CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5025
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.88453
CCNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95316
EVSAT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39655
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCC9	DepMap CRISPR Gene Dependency	1.0	3.79906
TARDBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60271
outer SZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39153
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
CEBPB	ENCODE Transcription Factor Targets	1.0	null
OR2B6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84863
PTGIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84964
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54048
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27016
TMEM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60291
OAW28	CCLE Cell Line Gene CNV Profiles	-1.0	-1.83798
FAM169A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18502
AHR	ChEA Transcription Factor Targets	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00963
REST_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11332
NCI-H2227	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MTHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27056
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.99308
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.934393
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32642
TE-4	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.92733
GSE149769_1_v_0_nlrp12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.459
GSE210580_4_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.928756
USP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85239
KPNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42233
MDAMB468	CCLE Cell Line Gene CNV Profiles	1.0	2.30159
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13276
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
inner SZ in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07246
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
MTMR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56611
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03891
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3805
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37441
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77471
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC3507642-1471-2164-13-355-S4.xlsx-direct_AR-repression_Cmpd30-UP-HUGO_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nucleus of the diagonal band, left, vertical division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0212
DBT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73106
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01121
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.842296
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
W chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.529
basal nucleus of meynert, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.827288
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.847915
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A7U0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69005
Prostate adenocarcinoma_PRAD_TCGA-G9-7519-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PICK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77277
NCI-H2110	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16507_OE_Rest_SRP314492	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.28918
KYSE450	CCLE Cell Line Gene CNV Profiles	1.0	1.58224
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.960914
PPARalpha_OE_GDS2289_244_mouse_Skeletal muscles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A54R-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ITPKC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62407
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31364
GRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38484
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ID4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.70678
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53585
Rectum adenocarcinoma_READ_TCGA-AF-2692-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KRBOX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61593
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dendrite membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.87
CRISPLD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7697
DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07211
LBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4274
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.126165
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61743
DSG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98829
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.849609
GSE87404,GSE87812_2_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GIPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.29381
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55882
NMRAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60587
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.1014
GSE135439_0_v_1_pax5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11843
layer I of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.853803
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-5095	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9442
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63758
GSE138019_3_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60353
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07435
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of brown fat cell differentiation	GO Biological Process Annotations 2025	1.0	null
DUSP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03564
BBIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83871
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70094
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.973806
GSE157555,GSE157556_0_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16125
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30281
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37063
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2941
SNX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55639
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1344
DRAM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63368
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18322
CDC37L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82286
lingual gyrus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.896123
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06137
AIRE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82072
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883919
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.928309
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3712200-584604.f1.pdf-12-ZNF721_ZNF721	Rummagene Transcription Factor Associations 2026	1.0	null
SLC25A44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14958
positive regulation of fat cell differentiation	GO Biological Process Annotations 2025	1.0	null
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164874_5_v_13_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88901
KU1919	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51682
MAGOHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13848
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
MZ in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39405
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8454
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04902
OCIM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51701
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51621
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50867
NCIH460	CCLE Cell Line Gene CNV Profiles	-1.0	-2.82048
GSE165647_5_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
B4GALT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69238
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03174
positive regulation of fat cell proliferation	GO Biological Process Annotations 2023	1.0	null
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF716	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27594
GSE113734_1_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.68979
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13757
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adenocarcinoma of lung_Lung Tissue_GSE1037	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.39141
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.2671
KCTD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27519
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A_CA_04_2009_7dayMOI-10^6_None_GSE37569	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.59965
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.37254
H3K27me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05971
ARNT	ChEA Transcription Factor Targets	1.0	null
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0013
response to BMP	GO Biological Process Annotations 2023	1.0	null
CDK20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78344
SMARCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40559
Adult body size	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.730103
Mural cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13271
GTEX-N7MT-0011-R4a-SM-2I3G9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963315
SSTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29565
enlarged kidney	MGI Mouse Phenotype Associations 2023	1.0	null
BTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64996
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
rectum	HPA Tissue Protein Expression Profiles	1.0	1.99308
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AHR-22903824-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-99-7458-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Renal parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.385
HK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26686
GSE232631_0_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2692
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9349
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-1.05138
TGFBR3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85664
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04631
VRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68677
SLC66A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20206
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Eye disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227415_1_v_0_ucp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TET1-21451524-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RCH-ACV	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.54534
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF362	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46028
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM150A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40047
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34864
SLC8B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71178
regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
STAT3-24763339-IMN-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CLPP_KO_GDS4791_108_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37344
BCL11B_KO_GSE9330_4_mouse_brain (striatum)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
MAGED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83445
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38795
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29209
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.26622
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920593
Rectum adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27199
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29125
ELMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15141
STOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08361
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48839
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11669572-CNS-30-e70185-s001.xlsx-Supplementary_Table_8-Supplementary_Table_8_Results_of_MR_analysis_for_causal_effects_of_genes_on_glioma_outcomes_at_the_brain_cell_level_replicated_dataset_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3BM-11A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF225	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31594
Pars distalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
ZFX_KO_GDS2718_150_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45613
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83626
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.904514
GPR120_KO_GDS4830_414_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Middle midgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.916
CMTM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75634
A-VN-1203-2004(H5N1)_Day2-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.57999
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2069
PPP1R12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12802
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.01753
USP32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69597
C18orf21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23299
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.972337
GTEX-NPJ8-0011-R3a-SM-2HMIW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844931
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_vs_LMS_-_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PTP4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81906
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.878155
ISHIKAWAHERAKLIO02ER	DepMap CRISPR Gene Dependency	1.0	5.06116
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18797
LU-65	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
GSKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36269
LMSU	DepMap CRISPR Gene Dependency	1.0	2.07294
CALML4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49312
postcentral gyrus, left, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00863
PSMB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11661
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847686
Brain Lower Grade Glioma_LGG_TCGA-DU-6403-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5849
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27081
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRKACB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76862
cellular response to growth factor stimulus	GO Biological Process Annotations 2025	1.0	null
ZNRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86774
VASH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81614
ZNF263	ENCODE Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.900859
PRDM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.70192
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937849
IP6K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79516
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
AMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34128
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863103
KDM4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41157
TES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16584
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850443
GTF3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43757
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41793
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85862
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CENPV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24541
PCI-15A	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
disease	GWASdb SNP-Disease Associations	1.0	0.024667
C2CD4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32719
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08086
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01341
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PTPRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54573
Perturb_11479_KO_Ring1_SRP321271	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.45465
PMC8905236-mmc2.xlsx-Table_S10-Table_S10_Differentially_regulated_genes_in_SPI1_high_vs_low_group_in_CGGA_GBM_dataset_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADAMTS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47517
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00249
P300-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6639
GSE125153_2_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_17580_KO_Rif1_SRP348198	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PPARGC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19033
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PTEN_01_302	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61308
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39605
basolateral nucleus (basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02372
Perturb_16522_KD_ASXL3_SRP247927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GARIN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0548
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.77086
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16341
EP300	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3516
SUPT16H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76573
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11182
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
TE-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.976843
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF232	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31258
HM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69361
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.88908
MRPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09951
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
brain	HPA Tissue Gene Expression Profiles	1.0	1.14606
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	0.861809
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.7851
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81M-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE5	DepMap CRISPR Gene Dependency	1.0	3.79947
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6005571__F10	PFOCR Pathway Figure Associations 2024	1.0	null
cuneus, left, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.928087
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSTA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29905
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4826
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ONDA8	DepMap CRISPR Gene Dependency	1.0	3.20578
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920026
Cervical cancer	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
ECE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66715
Prostate adenocarcinoma_PRAD_TCGA-EJ-7786-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Growth hormone receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.078
ACTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59989
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
PPP1R8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23604
VZ in postamygdaloid region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35059
cuneus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.9948
bacterial infectious disease	GWASdb SNP-Disease Associations	1.0	0.293692
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27016
NCI-H1568	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11148
ALDH6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68025
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5072
Perturb_8650_KD_GATA4_SRP287180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
KDM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10054
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MARK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19005
TMEM186	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29394
YY1	ENCODE Transcription Factor Targets	1.0	null
positive regulation of lipid storage	GO Biological Process Annotations 2023	1.0	null
GATA4-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_78_KD_BAP18_SRP074464	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.83664
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5732
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051782
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1116
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36394
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24267
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06286
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16651414-Supp2	GeneSigDB Published Gene Signatures	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25765
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34067
LXF-289	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2203
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47348
MMP23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.63868
JK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77416
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2729
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.159658
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATP11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18733
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VG-01A-31R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLSCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32771
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P31FUJ	CCLE Cell Line Gene CNV Profiles	-1.0	-2.28669
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6778-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10359_KD_Ascl1_SRP340223	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
NEURL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66833
Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0949
GATA2	ENCODE Transcription Factor Targets	1.0	null
ERVV-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58339
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08936
cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.126165
Macular degeneration	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
abnormal skin morphology	MGI Mouse Phenotype Associations 2023	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041212
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LCAM1	DepMap CRISPR Gene Dependency	1.0	3.86325
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51967
PHAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30812
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01344
TM9SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69191
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0246
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897887
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2177
FIBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27252
LAMA84	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42664
GSE180185_4_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.912557
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUM190PT	DepMap CRISPR Gene Dependency	1.0	2.44054
PIK3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67045
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59679
GSE202603_0_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_16101_KO_Map3k12_SRP157873	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.46495
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.946449
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05186
PMC7870953-41540_2021_169_MOESM9_ESM.xlsx-ZNF423_targets-target_gene_ZNF423	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1081
APOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35313
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03506
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.077
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H4K20me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974639
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00008
DLX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.98905
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERVV-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59751
Perturb_6369_KD_HAND1_SRP264999	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
REST	ENCODE Transcription Factor Targets	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.4215
METTL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18415
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH3255	CCLE Cell Line Gene CNV Profiles	1.0	2.00702
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1573	CCLE Cell Line Gene CNV Profiles	1.0	1.90248
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6639
CLPP_KO_GDS4791_377_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KHSRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90412
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848697
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
HNF3A	MotifMap Predicted Transcription Factor Targets	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054391
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MTRFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53975
NFATC2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58713
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	2.42032
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FUS-26573619-CHIP-SEQ-HEK293-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28865
NCIH510	DepMap CRISPR Gene Dependency	1.0	5.2907
Schaffer collateral - CA1 synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.814
RLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55566
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.46381
MZ in posterodorsal (superior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1086
EZH2	ChEA Transcription Factor Targets	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043739
CREB3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27812
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36482
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.44438
HOXA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9925
RNF122	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01127
GATA4_Deletion - for the second exon_GDS2316_712_mouse_Heart ventricles (of GATA4 animals heterozygous)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Eye Abnormalities	CTD Gene-Disease Associations	1.0	1.0894
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.97196
Prostate adenocarcinoma_PRAD_TCGA-G9-6385-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0011-R4A-SM-32PKM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04345
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5107
enlarged kidney	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08782
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
ZNF442	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13405
MOLT-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93309
Liver hepatocellular carcinoma_LIHC_TCGA-5C-A9VH-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHRDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24296
Perturb_14971_KD_Crebbp_SRP154933	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.45444
Perturb_9220_KO_Rai1_SRP074487	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.30436
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE155031_5_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF532	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60355
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914109
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20048
Perturb_10412_KD_MAP3K7/CHD1_SRP310151	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.3899
ZCRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03706
NR1H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49554
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48113
PYGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56175
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4060771-170289.f1.pdf-336-IRX4_IRX4	Rummagene Transcription Factor Associations 2026	1.0	null
HS852T	CCLE Cell Line Gene CNV Profiles	1.0	2.09589
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3363-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HA7-RCC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PSS131R	DepMap CRISPR Gene Dependency	1.0	2.3609
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.923201
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.61766
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.947996
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05494
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34204
Perturb_2580_KD_METTL3_ERP137121	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.70173
RAB23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2814
GSE110440_1_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49841
GTEX-T6MN-0011-R2A-SM-32QOW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877051
recurrent mycobacterial infections	GWASdb SNP-Phenotype Associations	1.0	0.670488
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33924
RAP2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24005
RXRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.278
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.75952
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14553
UBB_KO_GDS3906_494_mouse_Testis -  21 Days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.907708
16166618-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050472
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TE-8	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9131
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPARC_Deficiency_GDS3636_524_mouse_Lens epithelium	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
EMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87587
GRIN2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17118
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85001
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KLHDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33418
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01259
SRP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21263
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06275
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GLYATL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60813
CCNT2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
APPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82387
NELFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41357
ADD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3249
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.95824
NRL_Deficiency_GDS1693_238_mouse_Photoreceptors cells of retinas at P10	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.525489
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41754
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29628
Perturb_13750_KO_Bcl3_SRP179718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.1817
TCF12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4A-Supplemental_Table_S4A_Differentially_expressed_genes_upon_ZFX_Knock_down_in_C42B_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
regulation of brown fat cell differentiation	GO Biological Process Annotations 2025	1.0	null
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65098
Pituitary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.74885
regulation of lipid storage	GO Biological Process Annotations 2025	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M5-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF165	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80365
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2711
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.057424
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.943581
DKKL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56397
C1GALT1C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08694
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2209
OTULINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77083
Immunoglobulin-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
CDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59776
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
ALG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52304
Monogenic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26937
Kidney renal papillary cell carcinoma_KIRP_TCGA-UN-AAZ9-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99226
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42284
VB-89-RG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220447
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9929
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6724
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.886692
GSE155031_6_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
uterus	GTEx Tissue Gene Expression Profiles	-1.0	-0.826604
PMC6005571__F10	PFOCR Pathway Figure Associations 2023	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
SCA1_Knock-in_GDS3544_561_mouse_Cerebellum - 4 Weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34972
RUBCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03961
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58531
postcentral gyrus, right, inferior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.913562
RAB3GAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88741
Heschl's gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1323
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5080-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HES7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51707
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5095
CERT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69172
NOP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81597
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04741
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7129-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09976
RESF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31753
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ABHD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44875
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2461	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218735
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93955
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.88886
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.86788
HDH_CAG knock-in_GDS3935_569_mouse_Striatum and cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2689-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.67941
H3-3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00118
MDAMB453	CCLE Cell Line Gene CNV Profiles	-1.0	-2.44131
GTEX-QDT8-0011-R8A-SM-32PKE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962729
organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.126165
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85925
CSNK2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04265
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CAL-54	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888784
STK31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2712
IPMK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28509
HCC1599	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32535
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388758
TMEM14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64407
BCL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08632
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9139
GSDMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85832
ChIP_RNF2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Wnt signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.584
parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
DEPDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92539
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041235
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
647V	CCLE Cell Line Gene CNV Profiles	1.0	1.33087
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.597
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.690451
GSE181966_5_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12804025-mmc2.xlsx-LPS-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of gene expression	GO Biological Process Annotations 2025	1.0	null
FLI1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
USHBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78411
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.940414
BCL11B_KO_GDS3178_296_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5595
CTBP2	ENCODE Transcription Factor Targets	1.0	null
postcentral gyrus, right, bank of the central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.861239
SNX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99612
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.46465
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.981844
DAUDI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KNS60	CCLE Cell Line Gene CNV Profiles	1.0	1.55944
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10020087-41388_2023_2602_MOESM3_ESM.xlsx-MCF7_KD-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-450	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
abnormal kidney morphology	IMPC Knockout Mouse Phenotypes	1.0	null
hsa-miR-572	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
PRKCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52157
outer SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.826059
positive regulation of cellular process	GO Biological Process Annotations 2025	1.0	null
CLTC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36805
GSE138019_1_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19575
LCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67369
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2701
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3574
C3A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE244072_10_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195743_3_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.381147
RNF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7238
GPR153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82721
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3441
dorsolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.952794
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02513
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Spindle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.34
GSE244072_10_v_7_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
RHOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92389
OE21	CCLE Cell Line Gene CNV Profiles	1.0	2.25584
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A388	DepMap CRISPR Gene Dependency	1.0	3.02057
ITGB1BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51155
YTHDF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77265
TE9	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43695
abnormal caudal vertebrae morphology	MGI Mouse Phenotype Associations 2023	1.0	null
LCN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11532
KHNYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63143
mTert_OE_GDS1211_256_mouse_Embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
disease by infectious agent	GWASdb SNP-Disease Associations	1.0	0.146562
PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.275936
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAB33A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29573
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.83361
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20153
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RECQL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44912
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02154
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93314
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14614
GTEX-T8EM-1826-SM-4DM7F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878088
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FAM117B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8557
ISG20L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32056
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
PAWR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11705
NANOG	ENCODE Transcription Factor Targets	1.0	null
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.867405
PRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89043
DNASE1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70781
L-Wnt-3A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
CPSF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95285
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.906364
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30972
Multimerin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
FUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71531
Pectoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.987
KYSE30	CCLE Cell Line Gene CNV Profiles	1.0	1.89744
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.50631
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22059
MYL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63909
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28193
CA9-22	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
PCI-30	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5786
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3626
HCC4006	CCLE Cell Line Gene CNV Profiles	1.0	1.52968
GRM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00331
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04557
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.4
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23827
Prostate adenocarcinoma_PRAD_TCGA-KC-A7FE-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61313
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15498
CD81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11387
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20153
REST_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LT-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glis2_17618285_kidney_lof_mouse_gpl2897_gds2817	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.473206
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67422
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31776
KRAP_Deficiency_GDS3527_566_mouse_Brown adipose tissues	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
HOXC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29578
CELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29496
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4858740-ncomms11473-s2.xls-HAdV-D9_Cr1b_Library_2-Hit_name_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15356
MTMR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79309
Liver	GTEx Tissue Gene Expression Profiles 2023	1.0	1.4527
Prostate adenocarcinoma_PRAD_TCGA-XA-A8JR-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.70459
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
Eye-retinal bipolar neuron	Tabula Sapiens Gene-Cell Associations	1.0	0.225967
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96966
HDX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55772
SLC2A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3858
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.241
SPRYD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43304
Leiomyoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01714
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948752
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0538
MZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.84439
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33446
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44964
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-1.54348
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
EAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14492
TELO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8273
hsa-miR-3148	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26843
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186483_2_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32003
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD99	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25459
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144838_7_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35293
UBE2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29375
MS751	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
recurrent mycobacterium avium complex infections	GWASdb SNP-Phenotype Associations	1.0	0.670488
H157	DepMap CRISPR Gene Dependency	1.0	2.88404
TFAP4_01_295	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-4.1345
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9613
CDK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36212
RBBP5	ENCODE Transcription Factor Targets	1.0	null
TGFBR2_KO_GDS5008_282_mouse_Embryonic palatal mesenchymal cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE110268_1_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dental caries (decayed and filled deciduous teeth)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
RIMOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30658
TRAPPC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04592
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02129
CDY2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.01231
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19009
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0415
TTYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64705
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4426
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.1591
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A5KF-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DYNLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39557
SW-1116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCAR5	DepMap CRISPR Gene Dependency	1.0	2.11347
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01341
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NALM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.88926
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08164
PMC7846764-41598_2021_81773_MOESM3_ESM.xlsx-b-Heart_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BACH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73096
GATA2-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15983_KO_Larp7_SRP189392	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.699
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03556
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36769
GTEX-PWO3-0011-R1A-SM-2I5EW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824657
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF175	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10579
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0925
eye hemorrhage	MGI Mouse Phenotype Associations 2023	1.0	null
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.836254
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOTCH1_Deficiency_GDS2848_635_mouse_Hair follicles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ODF2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15979
WDR55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96517
TRIM28	ChEA Transcription Factor Targets	1.0	null
ACOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52265
outer SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28759
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
positive regulation of brown fat cell differentiation	GO Biological Process Annotations 2023	1.0	null
FOXA1-21572438-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03564
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35342
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	1.0	2.81675
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2931
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC25A29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24797
NB17	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55868
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43103
hsa-miR-3689a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
GSE242199_9_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal skin morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45981
GSE98755,GSE98756_1_v_0_fbxl19_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PHYH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72682
Perturb_17686_OE_HSD17B1_SRP366068	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.93339
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5303304-13073_2017_407_MOESM3_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_2-Table_S2_Genes_differentially_expressed_by_24h_RA_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977668
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.158502
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sirolimus_rattus norvegicus_gpl6247_gse35048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MKNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0734
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975768
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61H-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
STMN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77524
REST_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC35E4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69684
RBM27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30643
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A465-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5125
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal caudal vertebrae morphology	IMPC Knockout Mouse Phenotypes	1.0	null
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07258
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06033
GSE138001_2_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1435	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZBTB33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66627
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27267
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40471
CHD2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-AAVH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MUS81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.12809
PEX13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38382
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03486
lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67565
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_12_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06542
GTEX-N7MT-0011-R8a-SM-2I5GU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917923
GSE258991_5_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
XRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67227
DPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80575
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.928492
regulation of white fat cell proliferation	GO Biological Process Annotations 2025	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Age related macular degeneration	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
ZC3H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20555
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRSS35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29071
RAB34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54239
RPRD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31054
Duodenum Mucosa	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.0827
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.964318
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.68126
A_CA_04_2009_7dayMOI-10^5_None_GSE37569	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.80077
PGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54374
THBS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74967
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02628
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929918
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.20702
Perturb_5768_KO_Sip1/Nkx21_SRP010804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.00356
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RA-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of immune system physiology	GWASdb SNP-Phenotype Associations	1.0	0.101777
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.936214
Perturb_10297_Mut|KO_Pkd1_SRP385932	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.48282
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-toNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01741
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF251	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48074
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864238
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01259
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GLUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10469
Sensory ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.19412
GTEX-S7SE-0011-R2A-SM-2XCDC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866641
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.9248
PTBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51804
ETFRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74155
medial mammillary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42244
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
RFX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1997
EFM19	DepMap CRISPR Gene Dependency	1.0	3.07623
PRDM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34856
Lung adenocarcinoma_LUAD_TCGA-50-5066-02A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCDC66	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03966
TMEM106A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18725
ERMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06739
outer SZ in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.61964
REST	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE253943_1_v_2_bhlhe40_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64144
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07287
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.78232
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12941
A-Vietnam-1203-2004(H5N1)_2day-TNFRSF1BKO_None_GSE40792	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.89622
Perturb_118_KD_Fto_SRP314220	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Colorectal adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45021
Preadipocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.686
PMC6855629-pone.0225186.s003.xlsx-Sheet1-DEGs_repressed_by_MEIS1_in_human_cell_lines_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
DHX32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31872
GSE144838_7_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.851436
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37035
H3K27me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.57447
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
outer SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06448
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8814
hsa-miR-3689f	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ALKBH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36323
GSE133087_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKMEL24	DepMap CRISPR Gene Dependency	1.0	4.04
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
inferior nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17022
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-0011-R7a-SM-2HMJV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833706
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20048
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17949
HCC827	CCLE Cell Line Gene CNV Profiles	1.0	2.75636
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43471
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
BOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19253
cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NME2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09511
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05982
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20653
LZTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77038
NAALADL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33035
Perturb_14907_KO_Pgr_ERP140354	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
ATG13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1162
PDLIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11498
RUNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53543
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NGFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52199
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905648
Lung adenocarcinoma_LUAD_TCGA-91-8497-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPIPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36109
Uterine Carcinosarcoma_UCS_TCGA-N8-A56S-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LUZP1-20508642-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20653
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47407
16778185-Table1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999806
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.731767
Renal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WF-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7898758-40168_2020_994_MOESM4_ESM.xls-PRDM15_target_genes-Gene_PRDM15	Rummagene Transcription Factor Associations 2026	1.0	null
H3255	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00385
TET1-21451524-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54574
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548ah	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IF-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SF3B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64251
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87305
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bcl11b_18199763_brain_lof_mouse_gpl1261_gds3178	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.026764
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.028676
positive regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
LPIN1_OE_GDS2291_587_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.85021
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.82171
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.896979
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ChIP_H3K27me3_20682450_humanESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994139
TCF12	ENCODE Transcription Factor Targets	1.0	null
HBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62633
H3K27me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3609	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1504
planum temporale, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.928509
Fat cell (adipocyte)_Adipose tissue_Human	CellMarker Gene-Cell Type Associations	1.0	null
Immunoglobulin V-set domain	InterPro Predicted Protein Domain Annotations	1.0	null
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.848987
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.64169
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04401
D283MED	CCLE Cell Line Gene CNV Profiles	-1.0	-2.25277
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7Q0-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67534
HT-144	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BSDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99994
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21671
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16894
abnormal kidney morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886379
CTNNB_Activation (deltaNB-cateninER transgenics)_GDS1560_767_mouse_Skin - 1 Day	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NOTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86416
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050472
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L88	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OTUD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3895
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26799
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15561
prostate	GTEx Tissue Gene Expression Profiles	1.0	0.831786
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52204
MAPRE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.38456
DMRTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27689
ZNF470	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46902
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63793
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.839392
Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.831835
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.879255
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
KU812	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE238005_5_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6781
NCI-H835	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16117
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1727
Embryo Loss	CTD Gene-Disease Associations	1.0	1.04314
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MP-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ENTPD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46569
JMJD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97388
GTEX-WVLH-0011-R8A-SM-3MJFC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06523
ATP6V1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12517
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.727
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68A-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-LIN28B_correlates_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11932929-41388_2024_3264_MOESM4_ESM.xlsx-p_0_05_FC_0_5_n_675-Differentially_expressed_genes_in_MCF7_AR-isolated_BCSCs_after_4_days_GSK591_500nM_AR	Rummagene Transcription Factor Associations 2026	1.0	null
extracellular region	GO Cellular Component Annotations 2015	1.0	null
HADHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67398
ASCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49338
TOX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64595
GSE250560_1_v_0_foxo1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83538
PTPN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29775
BIN67	DepMap CRISPR Gene Dependency	1.0	10.6585
AARD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38942
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19746
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869145
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12411
EFNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36692
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179031_3_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3653	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Dlx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5653
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.302
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACVR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53834
PHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44215
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21665
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.665
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3441
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UQCR10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45493
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.99308
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.776031
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11036
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93606
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17202
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CLPP_KO_GDS4791_543_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
CHRD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73198
EFM192A	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41915
AMDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10944
FAM104B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93448
VIIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53262
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2357
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954084
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30787
KCNA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0809
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.6959
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
C19orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.05957
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2111
OE21	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
Retinal degeneration	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
LHX8_Deficiency_GDS3254_600_mouse_Newborn ovaries	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_951_KO_Suz12_SRP322809	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.67126
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42939
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
TTC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9452
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904092
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ITLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.363
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08766
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
TRAPPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20013
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-VB-A8QN-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of gene expression	GO Biological Process Annotations 2025	1.0	null
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17216
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2153_KO_Ring1_SRP321271	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.14784
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.93643
Perturb_13751_KO_Bcl3_SRP179718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.0707
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
EIF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21474
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25057
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07826
REST_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF827	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75965
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.686936
CAMK2N1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51413
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.929342
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ES4	DepMap CRISPR Gene Dependency	1.0	2.31728
UBB_KO_GDS3906_492_mouse_Testis -  14 Days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_8835_KO_RING1A_SRP345831	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.326
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971128
19168792-TableS3	GeneSigDB Published Gene Signatures	1.0	null
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.922155
TRIM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10868
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.835835
precuneus, right, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.828115
FOXP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27859
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47616
CCZ1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68438
CIBAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49202
RING1B-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.76284
HS729	DepMap CRISPR Gene Dependency	1.0	2.43119
NUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79997
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10956
hsa-miR-4483	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
LRRC75A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42719
MKRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32398
smarcc2_00000000_e12dot5_embryonic_cortex_lof_mouse_gpl6887_gse45629	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.350847
hsa-miR-3689e	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
GSE190316,GSE190324_0_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0011-R5a-SM-2HMJY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983027
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24259
HEXB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.3704
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.997181
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63911
Perturb_157_KD_Prmt1_SRP360688	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.64095
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GATA6-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SINHCAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77418
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.35139
ATP7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47822
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IG-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP2R3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88784
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27923
Ltk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25226
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Oxyphilic adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
all	GWASdb SNP-Phenotype Associations	1.0	0.028653
Primary enamel knot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.732
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4912
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3504
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.389
CEBPB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2767
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.865924
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03327
NRSF	MotifMap Predicted Transcription Factor Targets	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44534
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.911238
GSE210580_3_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-DLX5_DLX5	Rummagene Transcription Factor Associations 2026	1.0	null
C11orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12955
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_949_KO_Bhlhe40|Bhlhe41_SRP216680	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.7076
Waist-to-hip ratio adjusted for body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.861976
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STRA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00679
UXS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04968
CLPP_KO_GSE40207_397_mouse_Brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34425
GTEX-T5JC-1226-SM-4DM7C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99332
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10525
tuberculosis	GWASdb SNP-Disease Associations	1.0	0.773189
NCI-H1623	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27626
hsa-miR-3658	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
NCIH1993	DepMap CRISPR Gene Dependency	1.0	3.32764
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.1986
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3289
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12670081-mct-24-0704_supplementary_table_s10_suppst10.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Differential_expression_of_TFCP2-rearranged_RMS_Vs_Other_RMS_FC_3_padj_0_01_TFCP2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
REST_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917847
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54462
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE67266_5_v_1_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.858129
PMC8283158-mmc2.xlsx-TCF4_ChIP-symbol_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03891
TRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49529
Cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.973212
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22767
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.753118
ADRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07334
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.869704
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU410	CCLE Cell Line Gene CNV Profiles	1.0	1.58826
Perturb_15747_KO_Cnga1_SRP327351	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.142
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48974
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869145
immune system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.126165
outer SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06784
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EIF4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30403
MAN1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7068
LUDLU1	DepMap CRISPR Gene Dependency	1.0	5.52759
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16404
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ANKRD28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31679
Papillary renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26856
NCIH1838	CCLE Cell Line Gene CNV Profiles	1.0	1.78484
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39092
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11002
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NT5DC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7047
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE199606_3_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NLE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51904
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36338
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.3428
Perturb_13110_KO_Foxm1_SRP194062	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.76123
GSE114690_1_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CLPP_KO_GSE40207_381_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23204
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.935
CENPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20034
SETD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73004
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8353
PTGES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83307
CBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23854
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXO3_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
CCDC137	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14649
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45444
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99452
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09256
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA1	JASPAR Predicted Transcription Factor Targets	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6656
CEBPB-21427703-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13757
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.08853
RANBP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17834
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.859685
NIPBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70421
SIRT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73248
single kidney	MGI Mouse Phenotype Associations 2023	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-6211-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.685
GSE100316_3_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Subcutaneous tissue cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
MGAT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09023
Prostate adenocarcinoma_PRAD_TCGA-EJ-5532-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAL1-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61011
Lung adenocarcinoma_LUAD_TCGA-93-A4JP-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ORMDL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46607
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WDR26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30526
GTEX-QVUS-0011-R1A-SM-3GAD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847536
Kidney Chromophobe_KICH_TCGA-KN-8436-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9219_KO_Mecp2_SRP056141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
PRSS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07224
CAKI2	DepMap CRISPR Gene Dependency	1.0	2.04528
NECTIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06264
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.896266
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.86047
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.856168
FLNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.71467
SLC2A4RG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8945
GSE165274_1_v_2_poldip2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13294
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.725655
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.925713
ATF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51094
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37875
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.864242
Prostate adenocarcinoma_PRAD_TCGA-J4-8200-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4706
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4565
ZNF512	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86881
Rectum adenocarcinoma_READ_TCGA-AF-2691-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXM1-26456572-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10411_KD_MAP3K7/CHD1_SRP310151	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.6185
NBPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9475
MEGF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71248
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28809
lingual gyrus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5957
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCC-827	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
VPS29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47563
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.965772
Perturb_944_KO_Bhlhe40|Bhlhe41_SRP216680	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.1524
HMGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81589
Perturb_123_KD_Fto_SRP314220	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.41892
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTPN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9462
H3K4me1_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TC138	DepMap CRISPR Gene Dependency	1.0	2.1995
GATA3	ENCODE Transcription Factor Targets	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2601
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PCMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30697
MELHO	DepMap CRISPR Gene Dependency	1.0	3.79026
DPPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67047
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.050909
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7621
Lung squamous cell carcinoma_LUSC_TCGA-85-8351-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	0.853344
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04649
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01223
telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.931037
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SH-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28329
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158197_6_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12287
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87469
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.9565
TOMM40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69212
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
VDAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07988
A253	DepMap CRISPR Gene Dependency	1.0	2.06436
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.054522
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02963
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21496
USH1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27093
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97547
REST_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
bone marrow cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.126165
CDKN2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61137
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58128
RPS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4681
HGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71978
H2AX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96163
TE4	CCLE Cell Line Gene CNV Profiles	1.0	1.55172
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
SOD2_KO_GDS1080_128_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8059
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04027
COGN305	DepMap CRISPR Gene Dependency	1.0	4.00888
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36657
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
outer CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986342
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847517
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2279	CCLE Cell Line Gene CNV Profiles	1.0	1.61714
Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.98207
SCC15	CCLE Cell Line Gene CNV Profiles	1.0	1.81026
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DCTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77771
Perturb_10296_Mut_Pkd1_SRP385932	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.17356
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62164
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30641
BLOC1S6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91553
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46654
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.912269
NCIH1650	DepMap CRISPR Gene Dependency	1.0	2.96453
NPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60098
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CSTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19146
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0081
small kidney	MGI Mouse Phenotype Associations 2023	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31398
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71347
HCC-44	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68B-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colon	GTEx Tissue Gene Expression Profiles	1.0	0.965954
Angiomyolipoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14695
H4C8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20022
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Metanephric adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
PMC10944835-41467_2024_46639_MOESM4_ESM.xlsx-SD17-Supplementary_Data_17_Differentially_expressed_genes_according_to_homozygous_genotype_at_the_TWIST1_locus_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055971
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68769
CALR_KO_GDS3680_149_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58607
Kidney Chromophobe_KICH_TCGA-KL-8338-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20533
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32242
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OQ-11A-21R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF582	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16346
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.133
TMEM167B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50386
H3K27me3_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8747
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04963
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13858
cervix, uterine	HPA Tissue Protein Expression Profiles	-1.0	-1.54348
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FAM177A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43188
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06383
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12426
BBS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56601
RND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20537
CCNYL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34759
SOX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5078
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.950143
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL27	CCLE Cell Line Gene CNV Profiles	1.0	1.46045
GSE205291,GSE205292_1_v_3_drd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Blood Coagulation Disorders	CTD Gene-Disease Associations	1.0	1.0353
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.9582
GTEX-WWYW-0011-R7A-SM-3NB3H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9935
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RS411	CCLE Cell Line Gene CNV Profiles	-1.0	-2.12025
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07149
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-469-MAFK_MAFK	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44396
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.02708
Learning Disorders	CTD Gene-Disease Associations	1.0	1.02262
REST_Panc1_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.867405
UQCC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77618
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.08237
PLPP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51489
Serine deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
MS-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44604
TMEM41A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99052
DNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94586
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19264
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4706
positive regulation of lipid localization	GO Biological Process Annotations 2025	1.0	null
SNRK_overexpression_127_GSE30185	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.66053
cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1213
lingual gyrus, left, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.966839
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.870564
H3K27me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CMAH_KO_GDS4200_114_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Cardiovascular Abnormalities	CTD Gene-Disease Associations	1.0	1.0608
spleen	HPA Tissue Protein Expression Profiles	-1.0	-3.11439
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28416
EMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53761
postcentral gyrus, right, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.953234
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K27me3_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Extrachromosomal DNA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.627
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21847
C1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04606
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34474
GSE201520_8_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE181749_2_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
THAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54927
Extrachromosomal circular DNA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.853
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20653
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48342
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13455
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25354
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09256
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15911
LDHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84392
Prostate adenocarcinoma_PRAD_TCGA-HC-A8CY-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15770_KO_Uxt_SRP240277	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE159049_3_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RANGRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2551
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EMC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63247
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34785
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38342
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54062
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1611
RPL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26927
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20W-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single kidney	IMPC Knockout Mouse Phenotypes	1.0	null
COPS7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49322
NRSE	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994704
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.090993
prostate	HPA Tissue Gene Expression Profiles	1.0	0.894589
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.41257
cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Perturb_79_KD_BAP18_SRP074464	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.0246
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15356
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65G-01A-21R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.365633
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBE2I	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09384
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.249
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95259
DOV13	DepMap CRISPR Gene Dependency	1.0	3.36255
ANKRD63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87733
GSE193588_3_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C8orf33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53003
carboplatin_homo sapiens_gpl570_gse13525	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98264
ANO8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7162
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03253
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZNF33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05892
TMEM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73096
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50433
KYSE-520	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00301
positive regulation of fat cell differentiation	GO Biological Process Annotations 2023	1.0	null
REST_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-51	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RIC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28674
C2orf81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11998
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.19966
NIF3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11588
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05693
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CZIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37487
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962902
GSE180951_2_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
XPOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86531
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.152
RPS19BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76854
anterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.899268
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5697-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04169
Set3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.754
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834908
OCIMY5	DepMap CRISPR Gene Dependency	1.0	2.93385
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_16100_KO_Map3k12_SRP157873	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.68805
WAC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10158
MYC	ENCODE Transcription Factor Targets	1.0	null
BPTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14764
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1293
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EIF5AL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60724
ATF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30312
PSEN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88989
cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.157578
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06925
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.28322
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP2R5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32241
positive regulation of fat cell proliferation	GO Biological Process Annotations 2025	1.0	null
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12505
Perturb_9740_KO_Kcnj11_SRP279345	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.46256
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24308
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.70718
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185881,GSE185884_2_v_3_ctcf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OV56	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06345
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.76292
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
H3-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73527
Lung adenocarcinoma_LUAD_TCGA-50-6591-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5437
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935288
ZNF554	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29945
NCIH1568	CCLE Cell Line Gene CNV Profiles	1.0	1.58272
PDHX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02395
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843005
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03891
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915155
BICR78	DepMap CRISPR Gene Dependency	1.0	3.32744
Hemorrhage	CTD Gene-Disease Associations	1.0	1.24024
RIPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07254
SLITRK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76348
BMI1-23680149-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
primary bacterial infectious disease	GWASdb SNP-Disease Associations	1.0	0.385146
Prostate adenocarcinoma_PRAD_TCGA-Y6-A8TL-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43766
TRPS1_Mutation_GDS4493_594_mouse_Whisker pads	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946816
POLL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.25083
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.06652
HOMER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49608
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7669-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CME1	DepMap CRISPR Gene Dependency	1.0	2.30727
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.929
H3C7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19464
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Type 1 diabetes mellitus_T lymphocyte_GSE10586	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.29297
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6999
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23652
Degeneration of macula and posterior pole	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
UGT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25468
NOBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96392
UBXN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23421
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08782
Autosomal genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.538
H1-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72244
ENSG00000284691	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30719
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07841
REST_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.45373
PCI15A	DepMap CRISPR Gene Dependency	1.0	3.89231
EN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66433
TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.7821
hematologic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.126165
MITF	ChEA Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7154-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NCI-H1573	COSMIC Cell Line Gene CNV Profiles	1.0	2.22633
regulation of white fat cell proliferation	GO Biological Process Annotations 2023	1.0	null
TE8	CCLE Cell Line Gene CNV Profiles	1.0	1.49124
Perturb_15804_KO_Atf3_SRP350242	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
ALOX12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85915
GNB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39113
MBD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82097
DHX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95403
A-704 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.03
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.40694
nucleus	GO Cellular Component Annotations 2023	1.0	null
REST_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18378
TMEM184A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32508
MESSA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93561
PLEKHA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55012
ZBTB16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94933
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56184
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17539
GSE86507,GSE86509_7_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CLBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87709
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43148
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04022
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878942
extracellular region	LOCATE Curated Protein Localization Annotations	1.0	null
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAFAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60605
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67213
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E7-01A-31R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
External side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
HEL9217	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37689
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06488
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40501
STAT3	ChEA Transcription Factor Targets	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HTR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9434
COX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64307
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17497
Lung squamous cell carcinoma_LUSC_TCGA-90-A4EE-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
AGAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77478
FAM53C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1434
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
body of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.945067
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0034
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C12orf29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89704
GSE242199_2_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARNT-22903824-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74179
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.00993
GTEX-OHPN-0011-R5A-SM-2I5FF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861769
CORL23	DepMap CRISPR Gene Dependency	1.0	4.74906
MUSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62247
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936001
Arsenic	CTD Gene-Chemical Interactions	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TU-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76759
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4901
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10656
GSE214382,GSE214383_6_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RNF2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1293	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20533
H3C13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42201
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.26436
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977668
ZKSCAN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33004
NCOA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46391
PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78001
RASL10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64355
JMSU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50719
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2052	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34877
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.904439
ACSL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56063
Perturb_144_KD_Tmbim1_SRP319088	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.1549
GSE96991,GSE97117_5_v_0_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.854011
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-4J-AA1J-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5629025-elife-27159-fig1-data1.xlsx-Direct_AR_target_genes-Control_only_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPE	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2519
PMC4060771-170289.f1.pdf-622-NEUROD1_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null