association	dataset	threshold value	standardized value
Ubiquinone biosynthesis complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.052
SF-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.707
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-GSEA_TET2-Unnamed_6_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
FOXA2	ChEA Transcription Factor Targets	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52465
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32077
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
Stomach	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
alfuzosin-1586	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3176	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
sirolimus_homo sapiens_gpl96_gds2494	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.168349
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5452-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0326
SMARCA5	Pathway Commons Protein-Protein Interactions	1.0	null
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hTERT-RPE1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Perturb_11728_KD_Klf4_SRP338421	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.30562
CoPV part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09617
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100288_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34564
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.4365
MARCKS	Pathway Commons Protein-Protein Interactions	1.0	null
15869706-TableS2	GeneSigDB Published Gene Signatures	1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.27175
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Choriocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
PC14_LUNG	CCLE Cell Line Proteomics	1.0	5.98711
Perturb_1761_OE_Notch1_SRP311399	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.82193
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930283
GMPS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of CoPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09617
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K94903598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.361
GTEX-XBED-0126-SM-47JY7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825126
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of DNA recombination	GO Biological Process Annotations 2025	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2307
UPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20202
TMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51086
EWSR1_KD_GDS4962_465_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZC-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38972344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44621
BRD-K02180800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06832
double-stranded DNA binding	GO Molecular Function Annotations 2025	1.0	null
BRD-K31034311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27316
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1078-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018988
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
liver	HPA Tissue Gene Expression Profiles	-1.0	-0.970682
BRD-K22718400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1856
small_intestine	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.45001
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04706894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13305
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140746
any	GeneRIF Biological Term Annotations	1.0	null
BRD-K51697315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31542
PHLPP1	Pathway Commons Protein-Protein Interactions	1.0	null
USP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63192
GSE203158_5_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
subunit	GeneRIF Biological Term Annotations	1.0	null
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MHHES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58548
SYK_druginhibition_153_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.65453
endocrine/exocrine gland phenotype	MPO Gene-Phenotype Associations	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983016
Post-translational protein modification	Reactome Pathways 2024	1.0	null
BRD-K26127374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04331
CAPZB	Pathway Commons Protein-Protein Interactions	1.0	null
clomipramine-1566	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intriguing	GeneRIF Biological Term Annotations	1.0	null
perifornical nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.47316
SIN3A	ChEA Transcription Factor Targets	1.0	null
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960539
CTPS1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4714-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14855
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895627
Anterior cingulate area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.99251
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08616
positive regulation of double-strand break repair	GO Biological Process Annotations 2025	1.0	null
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922442
BRD-K71452779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37533
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.274109
Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2711
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CALML3	Pathway Commons Protein-Protein Interactions	1.0	null
iloprost-496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
embryonic lethality during organogenesis	MPO Gene-Phenotype Associations	1.0	null
RPL35A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859222
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07161
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YLPM1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-HEP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.814
KRT24	Pathway Commons Protein-Protein Interactions	1.0	null
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
CD55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74972
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.239007
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30781
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53713
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PHB2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95543908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1927
BRD-K51525251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91267
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138945,GSE138947_0_v_1_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_7_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41899
BRD-K12493093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48057
NR2F2	ENCODE Transcription Factor Targets	1.0	null
Nerve cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09991
hsa-miR-3148	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
H2BK5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.881624
Edema	CTD Gene-Disease Associations	1.0	1.31476
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	2.44526
BRD-K73994499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34565
Secondary motor area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.55247
GTSE1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K09693670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05035
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal survival	MPO Gene-Phenotype Associations	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1899
BRD-K18519876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31107
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.46436
BRD-K29466595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8849
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86208187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88899
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51895
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Rad51B-Rad51C-Rad51D-XRCC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.148
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIMM44	Pathway Commons Protein-Protein Interactions	1.0	null
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
MZT2B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76008396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50188
GSE242290_3_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Rhabdomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
clemastine-7443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC-2218	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.52261
GTEX-POYW-1326-SM-48TCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1398
6844_PSMA4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13112
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6972-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14515_KO_Esrrg_SRP331239	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.06236
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DLAT	Pathway Commons Protein-Protein Interactions	1.0	null
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12844
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09991
WD40/YVTN repeat-like-containing domain	InterPro Predicted Protein Domain Annotations	1.0	null
GPI	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.25437
hsa-miR-4417	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36308
BRD-K26195700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09306
LUC7L2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SSA3-0226-SM-32QPN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854836
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839181
BRD-K04650671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15115
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.7416
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073839
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204067
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16079
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06062
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53988
KDM6A-18722178-U937-AND-SAOS2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cullin-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.66
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49078
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11735
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
FOXP2_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCOF1	Pathway Commons Protein-Protein Interactions	1.0	null
PMEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08415
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13544
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
HLA-B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
S100A8	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0625
vacuole	LOCATE Curated Protein Localization Annotations	1.0	null
wdr20	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KC-45-DZ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205804
mantle zone of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41051
CDK1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K86232678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25658
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08613
KRT14	Pathway Commons Protein-Protein Interactions	1.0	null
CCFSTTG1	CCLE Cell Line Gene Expression Profiles	-1.0	-3.31487
fluphenazine-490	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE213988_0_v_1_rrm2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73C-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MKI67	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
single-organism developmental process	GO Biological Process Annotations 2015	1.0	null
PNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07774
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BPH-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48203
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07674
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.643797
SW1990	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07827
type	GeneRIF Biological Term Annotations	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE231891_1_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Progression Of Prostate Cancer	DisGeNET Gene-Disease Associations	1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.936846
BRD-K99847716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15796
mantle zone of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08391
GTEX-SIU7-1126-SM-2XCDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33051
PMC6604281__F1	PFOCR Pathway Figure Associations 2023	1.0	null
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08743
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79648
TET1	ChEA Transcription Factor Targets	1.0	null
hsa-miR-3680	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K41746201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14053
dizocilpine-1386	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.03084
hsa-miR-1305	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K31889353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84671
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM5A	ChEA Transcription Factor Targets	1.0	null
TCCSUP_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	3.74979
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.901467
IARS	Pathway Commons Protein-Protein Interactions	1.0	null
TTN	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K29936219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82575
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246449
Ubiquitin activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.096
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia	ClinVar Gene-Phenotype Associations 2025	1.0	null
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7521
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Swi5-Sfr1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.927
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295494
biological regulation	GO Biological Process Annotations 2015	1.0	null
abnormal spermatogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
FANCI	Pathway Commons Protein-Protein Interactions	1.0	null
RNASE7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06089
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.885334
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-2026-SM-3P61N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08779
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08094
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48931
Lung squamous cell carcinoma_LUSC_TCGA-85-7950-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.880534
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53914
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24987
r9 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04923
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86822
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.23422
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	1.0	null
preserving	GeneRIF Biological Term Annotations	1.0	null
Lateral ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Prelimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33266
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
TFCP2	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spastic Paraplegia	DisGeNET Gene-Disease Associations	1.0	null
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02961
NAE1	Pathway Commons Protein-Protein Interactions	1.0	null
SERPINE1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05536
BRD-K67194214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33045
GTEX-S7SF-1326-SM-4AD4P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11958
NACA	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.42918
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10899
Nystagmus	DisGeNET Gene-Disease Associations	1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54151
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.832601
Anterior cingulate area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35848
e2dependent	GeneRIF Biological Term Annotations	1.0	null
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851807
PIDD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85608
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4435
BL2679 (PHLPP1)	NURSA Protein Complexes	1.0	null
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.99085
RAD21	ChEA Transcription Factor Targets	1.0	null
NCI-H1299 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.999
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.853318
H4K8ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84705
BRD-K74198088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03466
thalidomide-266	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08737
BRD-K35336753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26887
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35769
keratinocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.667215
hsa-miR-452	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
MYC	ChEA Transcription Factor Targets	1.0	null
GTEX-Q2AG-0826-SM-2HMKF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83509
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59454
copper sulfate-500	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE240109_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-384	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAC3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.09023
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.687376
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.60661
Leaf axil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.112
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB33_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.41743
valproic acid-1060	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38633800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19474
BRD-K22812176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35042
BRD-K28455914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75511
BRD-K84457681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65832
complete embryonic lethality during organogenesis	MPO Gene-Phenotype Associations	1.0	null
BRD-K03837143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00029
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAE1	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02358
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4018
BRD-K16940345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4646
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98419
19218430-TableS3	GeneSigDB Published Gene Signatures	1.0	null
SF-21 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.4
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.960361
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
AR	ChEA Transcription Factor Targets	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527069
EEF1B2	Pathway Commons Protein-Protein Interactions	1.0	null
response to stress	GO Biological Process Annotations 2015	1.0	null
BRD-K64132098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90318
fluphenazine-1577	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.500603
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A118-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24253
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41954
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07055
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHAGOK1_LUNG	CCLE Cell Line Proteomics	1.0	4.67682
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29560103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20603
PMC8586238-41467_2021_26788_MOESM6_ESM.xlsx-S2A_CDE_genes-S2A_CDE_-_genes_of_the_two_CCD_genes_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9674
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EU-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
FTSJ1	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal skeleton morphology	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53967
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33725
9424_TUBG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521754
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29426
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873823
Fanconi Anemia	DisGeNET Gene-Disease Associations	1.0	null
Perturb_10962_KO_Arl10_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.39403
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5466-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72060858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38323
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^4_None_GSE44441	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.16818
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.827124
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12733
DNA repair pathways full network	WikiPathways Pathways 2024	1.0	null
Dinoflagellate epicone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.643
PPP1CC	Pathway Commons Protein-Protein Interactions	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2743
peptidase activator activity	GO Molecular Function Annotations 2023	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5672-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
hsa-miR-4463	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
lytic vacuole	LOCATE Curated Protein Localization Annotations	1.0	null
JHOS2	CCLE Cell Line Gene CNV Profiles	1.0	1.80417
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06744
CHP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04338
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T2YK-2226-SM-32QPT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892228
Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
valproic acid-497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adult Leiomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
GSE148066,GSE157787_2_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82497
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36145
OE-31-YC41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209065
GSE202434,GSE202438_12_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3152-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.21919
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059488
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.976368
LY-294002-258	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
sirolimus_mus musculus_gpl1261_gse21755	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KRT76	Pathway Commons Protein-Protein Interactions	1.0	null
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST1H1C	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QA-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79748783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29714
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15973
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.340297
MutLbeta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.583
BRD-K85513337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17781
BRD-K32930844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4619
RUFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12801
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_Q1_vs_Q4-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K78088874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22178
SUGT1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE180185_4_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12955049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76295
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal system morphogenesis	GO Biological Process Annotations 2015	1.0	null
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.81346
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-1726-SM-2TF4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40286
POLR2A_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73227372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35196
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29426
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU423_LIVER	CCLE Cell Line Proteomics	1.0	3.02784
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879036
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78146
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12824862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19679
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179605
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SHP77	CCLE Cell Line Gene Expression Profiles	1.0	1.56396
intermediate stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01754
rostral interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19772
mitochondrion-derived vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.037
PMC7932549__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PRC1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5711-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
PFKL_OE_GDS4410_75_human_Biceps muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2753
hsa-miR-4515	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.71391
BRD-K52175660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10497
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AOB, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0924
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7793
EWSR1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K19829092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39476
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.99941
Lung adenocarcinoma_LUAD_TCGA-97-7552-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
HOXB9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10082046-41467_2023_37049_MOESM7_ESM.xlsx-Sheet1-Supplementary_Data_4_Genes_upregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
decamethonium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15892
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.16964
BRD-K55209210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53808
MOLM-16 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
Encephalomyelitis	DisGeNET Gene-Disease Associations	1.0	null
RPMI-7951	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18378
RPMI8402	CCLE Cell Line Gene Expression Profiles	1.0	1.94894
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4Q7-0926-SM-4AD5D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833356
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36577
RAN	Pathway Commons Protein-Protein Interactions	1.0	null
SARS-CoV_60Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.63035
BRD-K56868780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73443
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55802
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27054
BRD-K66865641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63458
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
715_AURKB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.742333
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55698
Isoamylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
RBMXL2	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-7493-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12624449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66384
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46137
cyproheptadine-2021	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
chr3_39037170_G_C_b38	GTEx eQTL 2025	1.0	1.74105
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.09998
hsa-miR-600	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
WHSC1	ENCODE Transcription Factor Targets	1.0	null
MOB3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34658
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.361527
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39705
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00548
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318866
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Aa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
YY1_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
CSNK2A1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31977946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52488
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nystagmus	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_9545_KO_Ucp1_SRP187003	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.25936
LIN7C	Pathway Commons Protein-Protein Interactions	1.0	null
TRA2A	Pathway Commons Protein-Protein Interactions	1.0	null
PDCD7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	3.3475
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71188
BRD-K72800151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85757
Perturb_4509_KO_Tbc1d4_SRP374413	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
OCILY3	CCLE Cell Line Gene CNV Profiles	1.0	1.39052
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43232
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25735
prostate gland cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223177
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
P12ICHIKAWA	CCLE Cell Line Gene Expression Profiles	1.0	2.06728
Metabolic syndrome	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TUBB1	Pathway Commons Protein-Protein Interactions	1.0	null
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17603
BRD-K91784140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48761
BRISC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.744
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05461
CUL2	Pathway Commons Protein-Protein Interactions	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07114
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VDR	ChEA Transcription Factor Targets	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCBTB1	Pathway Commons Protein-Protein Interactions	1.0	null
bona	GeneRIF Biological Term Annotations	1.0	null
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49845
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
viral	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A264-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5244_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP275780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.19629
recruited	GeneRIF Biological Term Annotations	1.0	null
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.787
BRD-K47784262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12025
DMWD	Pathway Commons Protein-Protein Interactions	1.0	null
YAE1D1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TFG	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7129-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PIK3CA_druginhibition_57_GSE17785	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.21636
STK11	Pathway Commons Protein-Protein Interactions	1.0	null
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4038
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16134
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153397
TCF7-22412390-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72092
BRD-K35788497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32878
Cyclic Neutropenia	DisGeNET Gene-Disease Associations	1.0	null
OCRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23864
CHD7	ENCODE Transcription Factor Targets	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.846588
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41863
GSE186483_1_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JARID1A-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.6171
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
endometrium	HPA Tissue Gene Expression Profiles	1.0	0.857093
hsa-miR-4260	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_76_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
HCC-366	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.10403
receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047504
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01894
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10252
Lung adenocarcinoma_LUAD_TCGA-95-8494-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32184
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232981
DF-00-BX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26791
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36386
TSPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25941
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HSPH1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF605	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07061
SCH	GDSC Cell Line Gene Expression Profiles	1.0	1.87472
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-11A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24029
COL1A1	Pathway Commons Protein-Protein Interactions	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.04777
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064847
blastodisc	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.187738
GTEX-XUW1-1526-SM-4BOOY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85292
CSNK2A2	Pathway Commons Protein-Protein Interactions	1.0	null
ATAD5	Pathway Commons Protein-Protein Interactions	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.28579
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
positive regulation of epithelial cell proliferation	GO Biological Process Annotations 2015	1.0	null
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.959667
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K57343972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67082
GTEX-REY6-0526-SM-2TF5M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854002
GPN1	Pathway Commons Protein-Protein Interactions	1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.61637
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.26061
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169514
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48608
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.845
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 3 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9945
PMC5159535-supp_gkw757_nar-00810-met-z-2016-File016.xlsx-S9_SOM-Unnamed_3_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846579
abnormal male reproductive system morphology	MPO Gene-Phenotype Associations	1.0	null
BV173	CCLE Cell Line Gene Expression Profiles	1.0	1.54157
PMC12289921-41467_2025_62099_MOESM5_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4322	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAP3K7_knockout_246_GSE34417	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.44305
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77046
abnormal birth weight	MPO Gene-Phenotype Associations	1.0	null
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
SRRM2	Pathway Commons Protein-Protein Interactions	1.0	null
MAP1LC3B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MutSbeta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.028
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507555
BRD-K78438852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82527
LNCaP-AI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
TCF7	ChEA Transcription Factor Targets	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32378
BRD-K27137352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25453
vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.170114
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0427
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.243158
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.88547
protein modification by small protein removal	GO Biological Process Annotations 2015	1.0	null
hsa-miR-1321	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
combines	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-588	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.968745
VARS	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_14944_KD_Nmnat1_SRP102079	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.37776
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.64117
DGAT2L7P	Pathway Commons Protein-Protein Interactions	1.0	null
anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.03282
WRN	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A61304759_tanespimycin_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53662389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18954
Posterior midgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.898763
MMAC-SF	GDSC Cell Line Gene Expression Profiles	1.0	1.47963
IQSEC1	Pathway Commons Protein-Protein Interactions	1.0	null
CHAGOK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46766
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860528
nomifensine-1378	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsomedial preoptic area, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6635
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06888
Volasertib_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00929828
BRD-K54903703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21428
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSNK2A2	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K45612428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11949
BRD-K30283890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67105
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.916911
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.503829
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1	ENCODE Transcription Factor Targets	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52857
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5425
SLC25A13	Pathway Commons Protein-Protein Interactions	1.0	null
PCNA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GGH	Pathway Commons Protein-Protein Interactions	1.0	null
PHB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K28467941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63243
hsa-miR-650	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.06044
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7202
LCLC103H	CCLE Cell Line Gene Expression Profiles	1.0	1.52403
TAF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
WD40 repeat, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
single-stranded DNA binding	GO Molecular Function Annotations 2023	1.0	null
BRD-K14193598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00802
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.409189
WICH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.545
K562_Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152586
H2AC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06932
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal recessive cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
K562_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161157
revealed	GeneRIF Biological Term Annotations	1.0	null
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35274
CTSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25153
NCI-H2085	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
NCIH1385	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44425
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
TestisLeydigCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.66305
decreased birth body size	MPO Gene-Phenotype Associations	1.0	null
TNRC6B	Pathway Commons Protein-Protein Interactions	1.0	null
SK-MG-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFJO-0226-SM-3GIKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35188
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3464
BRD-K63858518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57805
AOB, internal plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39493
BRD-K62707745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.04811
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
RAD51AP1	Pathway Commons Protein-Protein Interactions	1.0	null
EMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79507
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060108
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52362
BRD-K54622858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5788
r2 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2338
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.1688
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229062
BRD-K32702774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43493
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61439332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30005
hsa-miR-3616-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
MCF7_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147014
FOXO1-32281255-CHONDROCYTES-HUMAN-OSTEOARTHRITIS	ChEA Transcription Factor Targets 2022	1.0	null
EB-09-JJ93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319992
BRD-K93186184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28452
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16219
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.969904
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.292527
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07501
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.575281
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.444529
496100518_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.63797
BRD-K19814171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24704
TBP	ENCODE Transcription Factor Targets	1.0	null
KRT78	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K37165790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53924
CTNND1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29936
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
6558_POLR3D_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04845
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-A19500257_geldanamycin_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21748
BRD-K50498614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43588
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC42	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K33179234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08259
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32589
GSE114992,GSE114993_8_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524169
stomach	HPA Tissue Protein Expression Profiles	1.0	1.48737
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	2.14411
FOXA1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67401
MCF7_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012908
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
u26684	HPA Cell Line Gene Expression Profiles	1.0	2.05656
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PPP1R9A	Pathway Commons Protein-Protein Interactions	1.0	null
embryonic lethality	MPO Gene-Phenotype Associations	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.593649
DCXR	Pathway Commons Protein-Protein Interactions	1.0	null
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199507
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOLEDO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15001
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2838
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53713
SNRNP35	Pathway Commons Protein-Protein Interactions	1.0	null
NR1I2-20693526-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K29549246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29875
YKG-1	GDSC Cell Line Gene Expression Profiles	1.0	1.46342
SETDB1	ENCODE Transcription Factor Targets	1.0	null
Osteosarcoma	DisGeNET Gene-Disease Associations	1.0	null
DDX17	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44864058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42903
DAG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00412351
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49709
BRCA1-BARD1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.872
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.346
phosphorylation	GeneRIF Biological Term Annotations	1.0	null
SIN3A-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.262755
Nucleus ambiguus, ventral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21243
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.833074
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12104
thyroid	GTEx Tissue Gene Expression Profiles	1.0	0.943483
Pontine gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06813
Lung squamous cell carcinoma_LUSC_TCGA-77-7335-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.55613
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54314
PSN1	CCLE Cell Line Gene CNV Profiles	1.0	1.48353
SOSS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.686
GSE148252_0_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.960475
skeleton phenotype	MPO Gene-Phenotype Associations	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pentamidine-639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A	Pathway Commons Protein-Protein Interactions	1.0	null
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29898553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07228
Flocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30104
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.376
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.627081
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27492
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.506989
Signaling by PDGFR in disease	Reactome Pathways 2024	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.649
BRD-K22988729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17847
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89116
LGALS3BP	Pathway Commons Protein-Protein Interactions	1.0	null
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lymphomatoid Papulosis Type A (Cd-30 Positive Type)	DisGeNET Gene-Disease Associations	1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.968745
CLEC14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42353
CAL-27	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53046
ATG4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20866
Lung squamous cell carcinoma_LUSC_TCGA-60-2716-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2029	CCLE Cell Line Gene CNV Profiles	1.0	1.44167
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51895
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
cellular response to stress	GO Biological Process Annotations 2015	1.0	null
MKK4	Kinase Library Tyrosine Kinome Atlas	1.0	95.84
Mre11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.829
basal nucleus of meynert, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11933
Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA3W-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44587
mantle zone of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75409
PPIB	Pathway Commons Protein-Protein Interactions	1.0	null
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
PRPF19	Pathway Commons Protein-Protein Interactions	1.0	null
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47311
SIX5	ENCODE Transcription Factor Targets	1.0	null
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP2	ChEA Transcription Factor Targets	1.0	null
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60732356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10525
DKC1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-0626-SM-2TF4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858578
BRD-K77591784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53883
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04526
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8524
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.31691
BRD-K32445732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69103
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892541
6801_PRPF4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.634894
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5677
DES	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76706127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0344
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44906
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EIF3F	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-IE-A6BZ-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1349_CCT5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532662
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KAT2B	ENCODE Transcription Factor Targets	1.0	null
Childhood Rhabdomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04635
BRD-K60454848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66304
Adult Rhabdomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20183527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04492
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAM122B	Pathway Commons Protein-Protein Interactions	1.0	null
cingulate cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21963
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC1B	CCLE Cell Line Gene CNV Profiles	1.0	1.93266
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A6UM-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07186
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.702
r10 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.26935
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.833074
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.026
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862912
CPNE1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28623804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73094
BRD-K22475995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59462
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2BK20ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Spastic Gait	DisGeNET Gene-Phenotype Associations	1.0	null
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09701
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
Seckel syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
H4K91ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Difficulty Walking	DisGeNET Gene-Phenotype Associations	1.0	null
IDH3A	Pathway Commons Protein-Protein Interactions	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29564
hsa-miR-421	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895627
BRD-K93486666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11786
BRD-K82249895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33454
dna repair complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.073751
BRD-K54621976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02652
BRD-A31576716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05797
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SRP19	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4396-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13084_KD_Wtap_SRP039402	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.61506
Ubiquitin conjugating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.086
SUPHD1	CCLE Cell Line Gene Expression Profiles	1.0	2.76239
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.978814
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AD-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.352565
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
SUMO-targeted ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.521
BRD-K72717797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1741
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.730346
hsa-miR-3646	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
periventricular stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46915
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09369
PMC7821388-DataSheet_3.xlsx-MYBL2_DDR_ChIPseq_Analysis-Gene_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52468958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57194
CEBPD	ENCODE Transcription Factor Targets	1.0	null
GTEX-T5JW-1226-SM-3GACY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865798
SARS-dORF6_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.80937
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.71157
Perturb_1866_KO_Ifnar_SRP371304	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.47653
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.52854
MHHNB11	CCLE Cell Line Gene Expression Profiles	1.0	1.62321
SCLC21H	CCLE Cell Line Gene Expression Profiles	1.0	1.73477
icSARS-Cov_Day1_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.61259
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Peritoneal exudate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.471031
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07856
TIFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01517
U2AF2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4296	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MDA MB435	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.64978
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27125
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-WK-A8XZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978145
BRD-K02637547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2864
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K48670593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11174
COLO205	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64106
CARM1	Pathway Commons Protein-Protein Interactions	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44913
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
B-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.003
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.39825
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06939
U251	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.01464
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01549
double-strand break repair via homologous recombination	GO Biological Process Annotations 2015	1.0	null
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.30405
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9982
monastrol-605	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUHR4TKB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33564
PMC7970325__F8	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K17482709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89559
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228181_2_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3BZ-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32617235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41368
anaphase-promoting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.508
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31171
subset	GeneRIF Biological Term Annotations	1.0	null
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K64823749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01593
caudal interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33682
praziquantel-1572	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78252315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36913
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ATG3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162399
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_24Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.3869
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
wd40repeat	GeneRIF Biological Term Annotations	1.0	null
BRD-K14216093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38114
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13803936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1261
KATOIII_STOMACH	CCLE Cell Line Proteomics	1.0	2.37663
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.97142
BRD-K50931403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0315
SAFB	Pathway Commons Protein-Protein Interactions	1.0	null
sleep disturbance	GWASdb SNP-Phenotype Associations	1.0	1.17517
BRD-K67177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20132
bone marrow	HPA Tissue Gene Expression Profiles	1.0	1.65611
GSE164874_5_v_6_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-HOXD8_HOXD8	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91500340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49644
Lung squamous cell carcinoma_LUSC_TCGA-22-4604-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WDHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07062
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7033
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59308
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09909
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
IST-SL2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4504
BRD-K21416096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30424
SNAP29	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
natural killer cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.26342
estradiol-1079	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
import	GeneRIF Biological Term Annotations	1.0	null
Bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.548
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31059159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04458
CUL9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45298
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994331
FACT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.676
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELOF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12699
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
FIS1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_8_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48852
UBE2G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88604
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
5194442-6599	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE197562_2_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.843
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.894186
KAP1-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Paragigantocellular reticular nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34781
Abdominal obesity-metabolic syndrome 1	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.865
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.36045
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46776
TIA1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF207	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9517
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GF1B-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81042
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Xanthine dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Nearest_Ensembl_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.84834
SNRPB	Pathway Commons Protein-Protein Interactions	1.0	null
calycanthine-6221	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.915387
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969362
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0043
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.976403
hsa-miR-4708-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.845385
PFKP	Pathway Commons Protein-Protein Interactions	1.0	null
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
CD4_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.28194
regulation of protein ubiquitination	GO Biological Process Annotations 2015	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
wdr48	GeneRIF Biological Term Annotations	1.0	null
CPCN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58995
recombinational repair	GO Biological Process Annotations 2023	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3922-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
FOXK1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-2.05719
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MARK2	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K85162983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26213
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57035
GSE168076,GSE168080_1_v_0_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32686643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36687
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
INO80-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.959
BRD-K25200031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6367
ATR-ATRIP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.498
genistein-638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_12672_KO_Smarca4_SRP191908	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.11393
B-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.141
DCAF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0007
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.987691
ATF2	ENCODE Transcription Factor Targets	1.0	null
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.24549
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7932549__F2	PFOCR Pathway Figure Associations 2024	1.0	null
HSPA4	Pathway Commons Protein-Protein Interactions	1.0	null
EZR	Pathway Commons Protein-Protein Interactions	1.0	null
COL11A2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S4UY-0926-SM-4AD6O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996809
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4595
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43682
containing	GeneRIF Biological Term Annotations	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
positive regulation of DNA recombination	GO Biological Process Annotations 2023	1.0	null
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K27416453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06049
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0356
OLFML2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07226
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Primary somatosensory area, lower limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02962
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242408
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62828
FLI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Hereditary spastic paraplegia 18	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.249
KRT17	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2B	ENCODE Transcription Factor Targets	1.0	null
HCC1482	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.952051
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16606
RFX5	ENCODE Transcription Factor Targets	1.0	null
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.865
BRD-K20160406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31643
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351442
PFKL_OE_GDS4410_202_human_biceps	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-1_UCSC_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Skeletal muscle cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.537
SUMO activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.41087
GSE151782_2_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NFK9-0326-SM-3MJGV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21904
SLC25A6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36164005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28236
GTEX-X5EB-2526-SM-4E3HY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836746
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.868618
CPSF6	Pathway Commons Protein-Protein Interactions	1.0	null
pancreas	HPA Tissue Protein Expression Profiles	1.0	0.90788
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QT-2026-SM-3NMCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851535
PF382	CCLE Cell Line Gene Expression Profiles	1.0	1.53515
abnormal birth body size	MPO Gene-Phenotype Associations	1.0	null
MYC-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40233
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K32343246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2968
serine	GeneRIF Biological Term Annotations	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
decreased oocyte number	MGI Mouse Phenotype Associations 2023	1.0	null
embryoday9.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.967039
BRD-K50240676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72291
Adult Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
ID-00-IC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241742
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13839
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69984
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral nerve cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07265
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316066
SOX11-22085726-ESNS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36223
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11518
Trachea	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.3
SCF ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.448
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89511
BRD-K82638914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01451
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Taurine dioxygenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.796
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Orbital area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48002
GTEX-PX3G-2026-SM-48U1H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06658
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
genistein-267	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K57045425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83008
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36122
VCP-NSFL1C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.618
BRD-K99210277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0717
17533364-TableS3	GeneSigDB Published Gene Signatures	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0126-SM-3NB1E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923315
hsa-miR-4701-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K24343968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40835
EZH2	ENCODE Transcription Factor Targets	1.0	null
UBXN1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WY7C-0226-SM-3NB37	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03939
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.51022
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.78925
FLNC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K09166899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25112
Normocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.659
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1990	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.903158
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.858938
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-KDM5B-Members_of_the_KDM5B_regulon_as_identified_by_SCENIC_KDM5B	Rummagene Transcription Factor Associations 2026	1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.870547
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03528
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-2.00846
PMC12271601-mmc2.xlsx-OUT_cells_03-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2129
4758_MAGEA12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.628725
rosiglitazone-1071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.422
CPCN	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48704
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.257005
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29438
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7485-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BL561 (COPS2)	NURSA Protein Complexes	1.0	null
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63232
ERG	ChEA Transcription Factor Targets	1.0	null
TERF2IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01622
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285016
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K55510118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5316
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852629
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
NSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48937
BRD-K11596967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37953
BRD-K05223209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51129
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
TRIP11	Pathway Commons Protein-Protein Interactions	1.0	null
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.631527
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K56895780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06455
UBA52	Pathway Commons Protein-Protein Interactions	1.0	null
SLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501422
MED30	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262562
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.10759
DYNLL2	Pathway Commons Protein-Protein Interactions	1.0	null
HSC-39	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.98915
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33895
RPS8	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
FOXP2-23625967-PFSK-1 AND SK-N-MC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
JARID1A-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57058
WM35	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.07218
BRD-K47541706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46333
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82432417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86624
D-392MG	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.04108
Compound leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.627
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.852566
BRD-K90962922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29525
TAL1-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAM175A	Pathway Commons Protein-Protein Interactions	1.0	null
TMEM191B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10466
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.908425
GTEX-XQ3S-1126-SM-4BOPK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67507
Anterior cingulate area, ventral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57424
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DNAJA2	Pathway Commons Protein-Protein Interactions	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.926529
testicular atrophy	MGI Mouse Phenotype Associations 2023	1.0	null
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.54419
sulfinpyrazone-6230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal oocyte number	MPO Gene-Phenotype Associations	1.0	null
abnormal reproductive system morphology	MPO Gene-Phenotype Associations	1.0	null
ventral anterior nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02761
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06913
GSE211177,GSE211178_9_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterior cingulate area, dorsal part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22806
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25257
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.7772
signals	GeneRIF Biological Term Annotations	1.0	null
PARP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00338788
BRD-K03381861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51057
4957_MED7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26289
BRD-K11165361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4313
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49855
GYPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00792073
COG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13468
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.69014
superficial stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.02248
superficial stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09617
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-3B-A9HR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of r1BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29256
IPO5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02568
PDHA1	Pathway Commons Protein-Protein Interactions	1.0	null
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NHP2	Pathway Commons Protein-Protein Interactions	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06249
USP1	Pathway Commons Protein-Protein Interactions	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dimenhydrinate-7431	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5374-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-PGR_PGR	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1522
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLG2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165647_5_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14449
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100489_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12473
BRD-K01995700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74681
CLTC	Pathway Commons Protein-Protein Interactions	1.0	null
TIMM50	Pathway Commons Protein-Protein Interactions	1.0	null
chromosomal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049648
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.56941
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5250-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5889
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61622
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.939862
hsa-miR-516a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.222
DNA repair complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.675
BRD-K12513721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38811
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0099
Lung squamous cell carcinoma_LUSC_TCGA-85-7710-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IZ in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05766
BRD-K82882121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10375
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K64640769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46946
breast	HPA Tissue Protein Expression Profiles	1.0	0.750846
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COPS2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055608
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.929622
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Posterior silk gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.52
ZBTB33_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCV JFH-1_24Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.42248
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
decreased germ cell number	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RXRA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hereditary spastic paraplegia 42	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
JAR	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.2296
lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.00349
BL6028 (WDR20)	NURSA Protein Complexes	1.0	null
g2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052234
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02155
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RecQ family helicase-topoisomerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.821
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.957341
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.80176
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single organism reproductive process	GO Biological Process Annotations 2015	1.0	null
PKN2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4506_KO_Clybl_SRP374413	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1577
BRD-K92239253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54127
HCC-1599	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.96882
KDM4C_natural variation_GSE41040_589_human_fibroblasts fron neonatal foreskin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MSH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18305
BRD-K37637965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19387
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.54448
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
XP-V XP30RO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.042
abnormal male germ cell morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K30937829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26655
ABL1	Pathway Commons Protein-Protein Interactions	1.0	null
placenta	HPA Tissue Protein Expression Profiles	1.0	1.48737
BRD-K46942548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03225
r11 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.69544
EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.53814
Orbital area, medial part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1957
GTEX-X62O-2226-SM-46MW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23535
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062814
Bursa of Fabricius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.58
cellular response to dna damage stimulus	GO Biological Process Annotations 2015	1.0	null
embryogenesis phenotype	MPO Gene-Phenotype Associations	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prelimbic area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51877
DGCR14	Pathway Commons Protein-Protein Interactions	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.531
BRCA1-B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
GTEX-QMRM-0726-SM-2I5G8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933395
LLGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00419
GTEX-SNOS-1226-SM-4DM5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866367
A-Vietnam-1203_CIP048_RG3-2004(H5N1)_24Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.47263
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RA-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-KD-A5QT-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERCC4-ERCC1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.704
PDCD6	Pathway Commons Protein-Protein Interactions	1.0	null
HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
r9 part of spinal trigeminal nucleus, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44148
BRD-K71298594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37806
Autosomal genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.865
BRD-K94573433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04041
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3916	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833154
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29M-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HuP-T4	GDSC Cell Line Gene Expression Profiles	1.0	1.60467
STOCK1N-35874-6583	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Secondary motor area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69402
GSE130437_2_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MSANTD4	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09913
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_unique_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
HSPA6	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZI-0226-SM-2XCEE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922449
GSE241036_0_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
arl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.625
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03452
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29464
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906245
PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
frontal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40827
Xeroderma pigmentosum group F	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
GTEX-T5JW-0926-SM-4DM5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933461
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43724
BRD-K82681356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18123
GSE154464_1_v_3_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00411149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24361
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-04-NN16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219758
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZFYVE26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16935
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12196
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.98461
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AIRE_KO_GDS2274_246_mouse_Medullary thymic epithelial cells (with high CD80 expression)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
RPS28	Pathway Commons Protein-Protein Interactions	1.0	null
nucleus of the diagonal band, left, vertical division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18452
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.179239
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
RNF126	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30914
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23898
BRD-K30198800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06154
skeletalmuscle	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.927233
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52153
18450603-Table3S	GeneSigDB Published Gene Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6828-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12931
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19965
DNA-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.945
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076899
r2 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28973
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882464
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.3484
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209458
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4825
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09733
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953673
BRD-K43261169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62978
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84524
BRD-K12011077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1525
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932701
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ternary	GeneRIF Biological Term Annotations	1.0	null
SFPQ	Pathway Commons Protein-Protein Interactions	1.0	null
TRPM7_defectivemutant_306_GSE23102	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.35453
protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
SCRIB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RL-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
vagina	HPA Tissue Protein Expression Profiles	-1.0	-1.01653
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10285
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.40327
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7593-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MutS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
FBXW5	Pathway Commons Protein-Protein Interactions	1.0	null
KPNA1	Pathway Commons Protein-Protein Interactions	1.0	null
PBX3	ENCODE Transcription Factor Targets	1.0	null
SW780	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.11661
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.98284
BRD-K73494324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52996
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15331
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34196
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35938
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TNKS1BP1	Pathway Commons Protein-Protein Interactions	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274174
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31048
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USP4	Pathway Commons Protein-Protein Interactions	1.0	null
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28305165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38591
TCF3	ENCODE Transcription Factor Targets	1.0	null
multicellular organismal reproductive process	GO Biological Process Annotations 2015	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.043422
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298171
PRDX2	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of cell proliferation	GO Biological Process Annotations 2015	1.0	null
BRD-K11672894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87423
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4427-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157755
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03667
CUL3	Pathway Commons Protein-Protein Interactions	1.0	null
sublayer 6a of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15858
cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088684
CP66-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00677
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.981
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7897-01A-21R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24543
Brain Lower Grade Glioma_LGG_TCGA-DU-6402-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
SYK_druginhibition_285_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.16587
BRD-K46641047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06834
Liver hepatocellular carcinoma_LIHC_TCGA-NI-A8LF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
mantle zone of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17533
OAT	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
LNZTA3WT4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.95271
BRD-K21119095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64699
KDM5B	ChEA Transcription Factor Targets	1.0	null
SPTAN1	Pathway Commons Protein-Protein Interactions	1.0	null
BL7613 (IQWD1)	NURSA Protein Complexes	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66843
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10252
DT-40 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.32
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27306
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82394273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21636
KB-65-GP42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263863
CSTA	Pathway Commons Protein-Protein Interactions	1.0	null
MYL6B	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.71273
A-Netherlands-602-2009(H1N1)_30Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.33158
raubasine-1748	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
interestingly	GeneRIF Biological Term Annotations	1.0	null
HMMR	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2I	Pathway Commons Protein-Protein Interactions	1.0	null
C-33A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.169
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0426-SM-3GIKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37725
THNSL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28414977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11548
BRD-K30121969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12719
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNA recombinase mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.755
MYL12A	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-11A-02R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20188
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.891779
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
AIFM1	Pathway Commons Protein-Protein Interactions	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.824853
Brain Lower Grade Glioma_LGG_TCGA-DU-7301-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3764
Adult T-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
PSMA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054384
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5690-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CALU-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.74105
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66434
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.60374
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59566
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3056
Childhood Osteosarcoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K68683482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98538
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	2.29874
CCDC93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30374
Malpighian tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
RELA	ENCODE Transcription Factor Targets	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80261
BRD-K20024170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53408
Frontal pole, cerebral cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15087
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF639	Pathway Commons Protein-Protein Interactions	1.0	null
NR1I2	ChEA Transcription Factor Targets	1.0	null
BRD-K85622666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06178
Lung	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.00221
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11538
cimetidine-1964	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.045976
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28272
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50499
K562_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152049
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
K562_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158179
E2F4_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XPNPEP3	Pathway Commons Protein-Protein Interactions	1.0	null
DSP	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27242
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376696
BRD-K17136501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65006
egg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.141919
BRD-K37506332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15476
hsa-miR-4292	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IE-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.32993
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86693
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.262755
Motor Axonal Neuropathy	DisGeNET Gene-Phenotype Associations	1.0	null
17023574-TableS1	GeneSigDB Published Gene Signatures	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.59511
SNU-387	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56575
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
PSME3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64839
TAF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SDF2	Pathway Commons Protein-Protein Interactions	1.0	null
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31479
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WRHU-1026-SM-4E3ID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09094
vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XK95-1026-SM-4GIDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975901
LSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06528
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73035
episome	GeneRIF Biological Term Annotations	1.0	null
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889172
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.614
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
YWHAH	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-J2-8194-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral ventrolateral reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.02248
AOB, mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00504
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH2172	CCLE Cell Line Gene CNV Profiles	1.0	1.88235
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.826396
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.953848
BRD-K45908502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81829
aciclovir-1960	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A11154023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18605
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2583
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20157
NELFE	ENCODE Transcription Factor Targets	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.3385
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09149805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1042
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40716
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.969678
Perturb_1240_KD_SRSF3_SRP033393	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.91379
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RISC-loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.546
GTEX-SUCS-0926-SM-4DM4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09068
Ataxia telangiectasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27817
CTSB	Pathway Commons Protein-Protein Interactions	1.0	null
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.60278
abnormal testis morphology	MPO Gene-Phenotype Associations	1.0	null
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
VAT1	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85216683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53038
Metabolism of proteins	Reactome Pathways 2024	1.0	null
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	2.93481
GTEX-U8XE-2526-SM-4E3IT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875091
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	2.74556
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914816
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.159856
Mantle cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79988
K562_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136445
layer 1 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.55849
GTEX-W5X1-0426-SM-3GILB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13298
BRD-K66145389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41649
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18726958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15429
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.589
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
mercaptopurine-334	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834254
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151423
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946488
GTEX-OXRP-0926-SM-48TC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44494
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
BICR31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4501
K562_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145039
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-V955-0426-SM-3GAEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32856
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal spermatogenesis	MPO Gene-Phenotype Associations	1.0	null
BRD-K58277621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22553
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68192
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839422
DSG1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFA5	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZW-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JARID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0099
PHLPP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1694	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03919
Penis_Foreskin_Keratinocyte_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.59319
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282304
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.336537
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1276
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21871
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.911596
RAB8B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100647_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01582
CRCGN015_MCF10A_48H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34208
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.922848
PKP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25719
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467509
BRD-K16689648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0898
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_unique_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52811
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03528
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92382
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
r4 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06863
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
ZSCAN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04375
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MF-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endodeoxyribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880622
BRD-K27248268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86519
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hsa-miR-553	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of epithelial cell proliferation	GO Biological Process Annotations 2015	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74600148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3779
BRD-K14868348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4555
abnormal oogenesis	MPO Gene-Phenotype Associations	1.0	null
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16963
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44994
SHQ1	Pathway Commons Protein-Protein Interactions	1.0	null
NBSUSSR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03424
trifluoperazine-421	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
DYNC1H1	Pathway Commons Protein-Protein Interactions	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17893805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42369
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60524
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26044
GSE148252_0_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RVPV-0526-SM-47JYL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31601
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YJ-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
hsa-miR-573	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8385
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08938
Female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9616
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12188
dna recombination	GO Biological Process Annotations 2015	1.0	null
chr3_38976235_T_C_b38	GTEx eQTL 2025	1.0	1.02391
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.05255
HEC1B	CCLE Cell Line Gene Expression Profiles	1.0	1.39609
Childhood Anaplastic Large Cell Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26166
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MV-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context1_2-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Metabolic Syndrome X	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
NEFM	Pathway Commons Protein-Protein Interactions	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39382
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.888638
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DNAJA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.11476
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1437	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68646
PHGDH	Pathway Commons Protein-Protein Interactions	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.614
NUDT21	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.51413
Adult Malignant Peripheral Nerve Sheath Tumor	DisGeNET Gene-Disease Associations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3TX-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.19338
BRD-K10241968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09646
STAT3	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_0_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138741,GSE138743_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
NKX1-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23727
CHD2	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-6560-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MutLgamma complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4P3-0226-SM-3K2BD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931931
BRD-K98601267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57412
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81N-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28373
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01802
BRD-K77465015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03606
CREB1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-7033-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WDR20	Pathway Commons Protein-Protein Interactions	1.0	null
SRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56161905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19219
NCIH810	CCLE Cell Line Gene CNV Profiles	-1.0	-2.36539
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT29	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00503
narcolepsy	GWASdb SNP-Disease Associations	1.0	2.26007
HMGB1	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHA-00767505E-6596	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7007-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXC9	ChEA Transcription Factor Targets	1.0	null
BRD-K21771449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55469
HMCES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45179
BRD-K16496880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40981
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28324
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2871
BL2310 (MLLT3)	NURSA Protein Complexes	1.0	null
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09267
RASSF5	Pathway Commons Protein-Protein Interactions	1.0	null
DF-00-BX35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230018
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20373726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17212
BRD-K09655230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28049
COP9 signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.285
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202858
Perturb_3006_KD_FAP_SRP285807	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.00882
YY1	ENCODE Transcription Factor Targets	1.0	null
BRD-K24220535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60979
r10 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05936
into	GeneRIF Biological Term Annotations	1.0	null
lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MAP1LC3B	Hub Proteins Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7866-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE86507,GSE86509_4_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25540102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30047
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.00698
NAF1	Hub Proteins Protein-Protein Interactions	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RXF393	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.889107
GTEX-T6MO-0226-SM-32QOL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33939
Hereditary spastic paraplegia 30	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
interspecies interaction between organisms	GO Biological Process Annotations 2015	1.0	null
Anterior cingulate area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66671
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.965064
NOP10	Pathway Commons Protein-Protein Interactions	1.0	null
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
outer CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20343
Mesothelioma_MESO_TCGA-SC-A6LR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.7006
CRTAP	Pathway Commons Protein-Protein Interactions	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24052
BRD-K09275191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97399
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPIL1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG5-0926-SM-2TC64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38898
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5551
SP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23631
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.816334
BRD-K98695520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48333
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290788
BRD-K87213231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07615
Acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
SIN3B	ChEA Transcription Factor Targets	1.0	null
single-stranded DNA binding	GO Molecular Function Annotations 2025	1.0	null
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.985845
MMS22L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25164
TUBA1C	Pathway Commons Protein-Protein Interactions	1.0	null
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391176
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16,16-dimethylprostaglandin E2-6597	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prelimbic area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16391
GTEX-XQ3S-1726-SM-4BOOD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854777
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12532
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Fanconi anemia complementation group D1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
C9orf72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76619
GTEX-R55E-1326-SM-48FCR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06042
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67587
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.07625
BRD-K15259298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1012
PAPOLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23392
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
liver	HPA Tissue Protein Expression Profiles	-1.0	-1.01653
BRD-K23075656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1005
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67991
LSM14A	Pathway Commons Protein-Protein Interactions	1.0	null
T24	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.58838
BRD-K12271646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05805
UACC893	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.778121
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX-27287812-CHIP-SEQ-EMBYONIC-LIMB-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
r9 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31599
BRD-K53274037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51801
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-1326-SM-4BRUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903477
Melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
SNB19	CCLE Cell Line Gene CNV Profiles	1.0	1.42804
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BAG4	Pathway Commons Protein-Protein Interactions	1.0	null
ChIP_SIN3A_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
copper sulfate-438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878836
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	1.23762
BRD-K65182930_NVP-AUY922_HEPG2_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NFF	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.72113
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
prenatal lethality	MPO Gene-Phenotype Associations	1.0	null
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.94361
BRD-K99048639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2584
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FAHD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62162
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
experiments	GeneRIF Biological Term Annotations	1.0	null
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85995
GALK1	Pathway Commons Protein-Protein Interactions	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7583-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RANBP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41287744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18123
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47694606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55575
BRD-K61560971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64104
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ZSCAN30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15549
ZFYVE21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04176
medial parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.838445
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BUB3	Pathway Commons Protein-Protein Interactions	1.0	null
ASF1A	Pathway Commons Protein-Protein Interactions	1.0	null
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29976
SF3B5	Pathway Commons Protein-Protein Interactions	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.801811
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-665	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
biological_process	GO Biological Process Annotations 2015	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73969016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06437
spermatogenesis	GO Biological Process Annotations 2015	1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PE-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased birth weight	MPO Gene-Phenotype Associations	1.0	null
BRD-K99078335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19077
AHCY	Pathway Commons Protein-Protein Interactions	1.0	null
recombinational repair	GO Biological Process Annotations 2015	1.0	null
GSE201735_3_v_1_cdca7_human	RummaGEO Gene Perturbation Signatures	1.0	null
suppressors	GeneRIF Biological Term Annotations	1.0	null
BRD-K20897375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02631
mcf7	HPA Cell Line Gene Expression Profiles	-1.0	-1.08984
TP53	Hub Proteins Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6481-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
recombinational repair	GO Biological Process Annotations 2025	1.0	null
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327438
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.566513
METTL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10111
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Childhood Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33102216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23761
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35247
BRD-K89121101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57202
LMO2-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5280-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43396
hsa-miR-3647-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12816669-41698_2025_1236_MOESM1_ESM.pdf-1154-SNAPC5_SNAPC5	Rummagene Transcription Factor Associations 2026	1.0	null
Abdominal obesity-metabolic syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.865
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FYCO1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02271
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.649429
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
usp1	GeneRIF Biological Term Annotations	1.0	null
PLEC	Pathway Commons Protein-Protein Interactions	1.0	null
layer 5 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2545
hsa-let-7e-5p	MiRTarBase microRNA Targets	1.0	null
r10 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75211
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AKT1_knockout_214_GSE39699	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.77992
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218893
BRD-K96839404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00917
TNPO2	Pathway Commons Protein-Protein Interactions	1.0	null
lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.102514
POU2F2	ENCODE Transcription Factor Targets	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214555
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
RH-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42615
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.45268
Anterior cingulate area, ventral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72898
BRD-K02565327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72134
NUDT1	Pathway Commons Protein-Protein Interactions	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1291
Shu complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.681
BRD-K50177531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51002
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01303
Liver hepatocellular carcinoma_LIHC_TCGA-K7-A5RG-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.609
KNS62	CCLE Cell Line Gene Expression Profiles	-1.0	-2.00021
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14131
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.464
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K99660943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38312
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
EIF2AK4	Pathway Commons Protein-Protein Interactions	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.14405
Brain Lower Grade Glioma_LGG_TCGA-DU-6410-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
FOXP2-23625967-PFSK-1-AND-SK-N-MC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VCP-NPL4-UFD1 AAA ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.725
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09138
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UACC62_SKIN	CCLE Cell Line Proteomics	1.0	2.39306
CELF2	Pathway Commons Protein-Protein Interactions	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01802
BRD-K33783177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26161
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1285
osteoblasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39552
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12776
GTEX-OHPK-2026-SM-3MJH7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00567
mantle zone of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31656
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900981
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891623
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1609
COX5B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5184
JVM3	CCLE Cell Line Gene Expression Profiles	1.0	1.42905
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29167
H3K9me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276021
RPLP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26734305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1211
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37973
growth	GO Biological Process Annotations 2015	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02155
FOXP2	ENCODE Transcription Factor Targets	1.0	null
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4318
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.8272
AF-83-BX08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201339
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
HNRNPCL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K78866450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4205
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206482
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.537494
PMC9883437-41467_2023_36150_MOESM4_ESM.xlsx-Chromatin_Regulators-AIRE_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02904
KRT13	Pathway Commons Protein-Protein Interactions	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.05052
RAB11FIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28926
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93126086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27306
CHL-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.42516
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4435
indicated	GeneRIF Biological Term Annotations	1.0	null
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
ALB	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Anterior cingulate area, ventral part, 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14809
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71566411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05095
GTEX-WI4N-0726-SM-3TW93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01638
BRD-K26063034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00497
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.52192
BRD-K20530300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85436
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300209
tuberomammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.72754
BRD-K40923781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11335
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24156533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24599
BOP1	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00964
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.890241
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29503
HNRNPH3	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
double-strand break repair	GO Biological Process Annotations 2025	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37911
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7970325__F8	PFOCR Pathway Figure Associations 2024	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14383
BRD-K38854468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3291
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Zeta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.571
MYC	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RRP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18212
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47377
BRD-K62781263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50101
BRD-K27600134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22917
hsa-miR-3614-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13112
hsa-miR-4492	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5453-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_72_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
17952126-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.74
BRD-K70532227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73261
NETO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12131
CMG complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.56
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.21914
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE66724_DE-Genes_NOT_Autophagy_NOT_GSE22255_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04097
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905497
deubiquitinating	GeneRIF Biological Term Annotations	1.0	null
CADM1_KO_GDS2026_301_mouse_testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SSU72	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Osteosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.66
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51298
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
usps	GeneRIF Biological Term Annotations	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LEPRE1	Pathway Commons Protein-Protein Interactions	1.0	null
BL2683 (PHLPP2)	NURSA Protein Complexes	1.0	null
ILF3_02_94	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.64295
U2-type spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.657
organ morphogenesis	GO Biological Process Annotations 2015	1.0	null
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.23443
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0324
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
decreased male germ cell number	MGI Mouse Phenotype Associations 2023	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98639224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18211
BRD-K56357490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34101
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.14009
RPS20	Pathway Commons Protein-Protein Interactions	1.0	null
LYZ	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61278167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53485
testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VCaP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.868
male gamete generation	GO Biological Process Annotations 2015	1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
MAX	ENCODE Transcription Factor Targets	1.0	null
BRD-K30492965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25122
BRD-K20028052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46193
CADM1_Deficiency_GDS2027_722_mouse_Testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
DDX18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19278
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.61219
Caov-3	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.40544
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
small testis	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-520g	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07005
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.79093
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63305
KRT16	Pathway Commons Protein-Protein Interactions	1.0	null
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.08028
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.942869
km3	HPA Cell Line Gene Expression Profiles	-1.0	-1.39319
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80K-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17157
UPF1	Pathway Commons Protein-Protein Interactions	1.0	null
KDM4A	Pathway Commons Protein-Protein Interactions	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
POLR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49311
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04535
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.33464
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6827-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBE4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56188
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VMRCLCD	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64031
BRD-K46924722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27156
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09753
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.36909
reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.192344
BRD-K02230174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64523
Poisoning	CTD Gene-Disease Associations	1.0	1.09716
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25044
RAC3-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95938
Autosomal dominant disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.865
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972121
GSE198165,GSE198166_5_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
L363	CCLE Cell Line Gene Expression Profiles	1.0	1.43833
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.06632
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49159670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4313
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
CALU1	CCLE Cell Line Gene CNV Profiles	1.0	1.64465
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
WD40-repeat-containing domain	InterPro Predicted Protein Domain Annotations	1.0	null
mantle zone of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06273
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57737
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81932
hsa-miR-636	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
UIMC1	Pathway Commons Protein-Protein Interactions	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TET1-21451524-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
rosiglitazone-5230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rad6-Rad18 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.6
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00564
OPTN	Pathway Commons Protein-Protein Interactions	1.0	null
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
LENG1	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1435	CCLE Cell Line Gene Expression Profiles	-1.0	-2.30655
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AIM2 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.501
Bosentan (hydrate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00572774
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.998924
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
Interpeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2538
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_61_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
sirolimus-5932	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72843176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19705
BRD-K88625883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22218
BRD-K76985713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1259
GTEX-RNOR-0426-SM-2TF4U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879758
Epsilon DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.373
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3363-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-0226-SM-32PK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893808
NCI-H1355	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.03119
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.541
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09629
HCoV-EMC2012_3Hour_23631916_GSE45042	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.47368
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Holliday junction resolvase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
BRCA1-C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.683
Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAPZA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87413
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5705-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
19286929-SuppTable2q	GeneSigDB Published Gene Signatures	1.0	null
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mediated	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-2114	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146133
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854984
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313167
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZH-1426-SM-4DXSR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08211
r1 part of dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1708
T84	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959724
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
famotidine-2029	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59242
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.52371
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nuclear replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.728
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4038
GTEX-TSE9-0326-SM-3DB82	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926774
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282493
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.865
TNRC6C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE173307,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24999
prostate	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.910293
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HB-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.96686
ChIP_MYC_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
t cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.277406
BRD-K45909830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21138
K562_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155339
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JA-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM160	Pathway Commons Protein-Protein Interactions	1.0	null
MMAC-SF	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.878469
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.968745
fertilization	GO Biological Process Annotations 2015	1.0	null
PDIA6	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5443-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF4	ChEA Transcription Factor Targets	1.0	null
MYH10	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46117
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A76B-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K12240312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55296
REH	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45799
AP3M1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K93519076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33237
BRD-K34737616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78351
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SOS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24665
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4865-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRGQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04191
MDAH-2774 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.59064
SNRPC	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.98552
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-O5YT-0926-SM-48TDG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842011
ATF1	ENCODE Transcription Factor Targets	1.0	null
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1395	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03528
CXCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32258
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32266
LGALS7B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.893973
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BAG5	Pathway Commons Protein-Protein Interactions	1.0	null
MZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07018
IZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833478
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69889
BRD-K14258088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44941
KLHL12	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67323
Inflammatory Myofibroblastic Tumor	DisGeNET Gene-Disease Associations	1.0	null
BRD-K55884477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3532
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNX27	Pathway Commons Protein-Protein Interactions	1.0	null
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.901684
PMC10806738-mmc2.xlsx-Table_S2-Table_S2_Table_of_significantly_adjusted_p-valued_0_05_down-regulated_genes_log2FC_-1_in_MAX-R60Q_transfected_HEK293_cells_relative_to_MAX-WT_transfected_cells_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48443
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.613199
BRD-K51446586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11648
RNPC3	Pathway Commons Protein-Protein Interactions	1.0	null
NFKB1_01_167	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	9.7321
BRD-K19501975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31277
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.858938
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K23ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TNPO1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K26543702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08109
CWR22-Rv1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
magnocellular interstitial nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12729
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.537171
BRD-K97569931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6063
hsa-miR-4685-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
hsa-miR-218	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
mebeverine-1576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anterior cingulate area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76964
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.853768
NCIH2452	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75267
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47984
BRD-K99077411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37192
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H596 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.448
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.65226
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
ANAPC1	Pathway Commons Protein-Protein Interactions	1.0	null
NUP88	Pathway Commons Protein-Protein Interactions	1.0	null
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.523
6768_PRKDC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.672757
GSK3_INHIBITION_GDS4043_459_human_MLL leukemia cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NUP160	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68008192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37814
Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKAR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14674
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173509
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ARL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3376
BRD-A19500257_geldanamycin_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K75413392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3504
A-Vietnam-1203-2004(H5N1)_24Hour_21865398_GSE28166	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.64036
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95429
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7596-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29142
YBX3	Pathway Commons Protein-Protein Interactions	1.0	null
survival	GeneRIF Biological Term Annotations	1.0	null
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ILF2_02_88	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58558
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNA2	Pathway Commons Protein-Protein Interactions	1.0	null
SQSTM1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RET_druginhibition_184_GSE49414	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.63279
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3854
AMPD1	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25655
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.92375
IER3IP1	Pathway Commons Protein-Protein Interactions	1.0	null
ITCH	Pathway Commons Protein-Protein Interactions	1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42378
Malignant Peripheral Nerve Sheath Tumor	DisGeNET Gene-Disease Associations	1.0	null
orbital frontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.853318
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE122509,GSE122513_2_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40496
BRD-K34117117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40316
BRD-K20138377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62762
GTEX-U4B1-0926-SM-4DXUV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41237
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07333
BRD-K46001734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11247
AP3B1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRC-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
SNRPD1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57356
hsa-miR-4506	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC6604281__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.59
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4620-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A688-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929738
RFC4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FANCD2	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2189
6847_PSMA7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12348
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48326
H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00678
BRD-K69790201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0762
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48283
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7594-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
reproductive structure development	GO Biological Process Annotations 2015	1.0	null
GTEX-TKQ1-0126-SM-33HB3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980955
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
POLR1C	Pathway Commons Protein-Protein Interactions	1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
melanocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.62865
U118	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.926621
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.938673
SPI1	ENCODE Transcription Factor Targets	1.0	null
RER1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31081052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81462
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04603
Frontal pole, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1904
BRD-K84013239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24777
ALDH1B1	Pathway Commons Protein-Protein Interactions	1.0	null
RABAC1	Pathway Commons Protein-Protein Interactions	1.0	null
skeletal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080815
BL-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.049
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317295
embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.348519
BRD-K37592272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24735
BRD-K47409867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58723
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.654523
BRD-K18594025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.06571
abnormal skeleton morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K88720906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.171
Anterior olfactory nucleus, external part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68772
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-593	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
RUNX2	ChEA Transcription Factor Targets	1.0	null
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03555
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RDX	Pathway Commons Protein-Protein Interactions	1.0	null
PTBP3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE-9	GDSC Cell Line Gene Expression Profiles	-1.0	-1.91338
FLYWCH1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-5307-01A-01R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.556
KRT2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77032979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96119
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSTP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942776
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARPAS-45	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	4.14164
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.369
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE220600_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Aggresome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.87
SYK_knockdown_279_GDS3609	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.55715
Leiomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K72933250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22136
Hereditary spastic paraplegia 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
origin	GeneRIF Biological Term Annotations	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.530654
Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KRT5	Pathway Commons Protein-Protein Interactions	1.0	null
HS683	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63208
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865587
ACTR1A	Pathway Commons Protein-Protein Interactions	1.0	null
PEX11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13864
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
MOLT4	BioGPS Cell Line Gene Expression Profiles	1.0	1.1827
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YKT6	Pathway Commons Protein-Protein Interactions	1.0	null
RBM15	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84252
RPS6KA3_knockout_73_GSE22137	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.94161
HNF4alpha_KO_GDS1916_168_mouse_Embryonic liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K10812033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5352
Liver Failure, Acute	CTD Gene-Disease Associations	1.0	1.08337
CAL120	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6701
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	3.45004
BRD-K12836153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59328
TOPBP1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-92-7340-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T3M10	CCLE Cell Line Gene Expression Profiles	-1.0	-2.95849
PRMT1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11075
Mobilized_CD34_Primary_Cells_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.19599
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01759041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4788
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.826385
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.253961
positive regulation of double-strand break repair	GO Biological Process Annotations 2023	1.0	null
GI-ME-N	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.04568
E2F1	ChEA Transcription Factor Targets	1.0	null
sirolimus-4466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K43029808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22303
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blastomere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085546
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5587-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201206
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.2298
HSD17B10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K75844518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32411
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987802
maintenance	GeneRIF Biological Term Annotations	1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_38_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
P30-OHK	GDSC Cell Line Gene Expression Profiles	1.0	1.60339
EEF1A2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4225-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
BRD-K73573019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24567
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355326
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16983
Teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SETDB1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041275
NUDT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27609
BRD-K60850201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49936
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24766
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857652
BTK_knockout_2_GDS1346	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.066462
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.516325
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4435
BRD-K24965236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87363
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.945291
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20590138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5783
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7841
BRD-K77697841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66846
mantle zone of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21963
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39705203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07047
BRD-K02269304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33077
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27549
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.954618
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
STRA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36415
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942231
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GTEX-SNOS-0226-SM-32PLR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930585
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8RZ-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
oculomotor nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10427
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18527484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39474
Elg1 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.92
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32393
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8618_OE_Orai1_SRP224071	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.34583
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03851
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
CREB1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hypersomnia	GWASdb SNP-Phenotype Associations	1.0	2.21842
BRD-K54370483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06329
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3132	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ABHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00763
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K62372121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78638
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955608
monorden-493	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48533
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49182
Bipolar Disorder_Cerebral cortex_GSE12649	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.42549
GSE195559_3_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.05354
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4653
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.304771
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3025
BRCA1	Hub Proteins Protein-Protein Interactions	1.0	null
HSPA4L	Pathway Commons Protein-Protein Interactions	1.0	null
6118_PCED1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.74483
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cdx2_21074721_jejunum_epithelium_lof_mouse_gpl10773_gse23436	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.998744
BRD-K77252933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6778
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43741
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-OV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4435
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3631
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910855
hsa-miR-663b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85104
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lysosome	LOCATE Curated Protein Localization Annotations	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_73_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of CCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21963
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV MA15_Day4-PFU-10^2_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.04965
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4607
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24C-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hereditary spastic paraplegia 26	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
UBA3	Pathway Commons Protein-Protein Interactions	1.0	null
DEL	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.10918
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07652
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG8-0426-SM-3GILD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830968
DNA damage response	GO Biological Process Annotations 2023	1.0	null
yy2_20215434_hela_lof_human_gpl570_gds3788	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.501654
PMC11551338-pnas.2411189121.sd01.xlsx-FXR-Unnamed_0_NR1H4	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00504
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368428
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45522895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63756
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.320454
Sarcoma_SARC_TCGA-X2-A95T-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8114-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87942399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48438
Ventral nerve cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.901
BRD-K82509605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2507
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71615409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32977
5762_NPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29687
NDUFS2	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8506-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
C11orf73	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35226
BRD-K51175229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76771
protein binding	GO Molecular Function Annotations 2015	1.0	null
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.242
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988136
amoxapine-2013	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7244323-elife-55325-supp3.xlsx-Noordermeer_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
6866_PSMD12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52571
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-MJ-A68H-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4519	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACTA2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K90594901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26859
stimulatory	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59883
NOTCH1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K59434830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.073
Penis_Foreskin_Fibroblast_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.49818
K562_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169976
GSE199899_1_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0501
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TRMT2A	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48518
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70643771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0438
BRD-K61621331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0246
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.356314
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SEC23A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE162575,GSE162609_3_v_2_tfe3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PVOW-1626-SM-48TC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07251
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.651
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.193394
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20131
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83466
BRD-K62000282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89315
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.16282
abnormal seminiferous tubule morphology	MPO Gene-Phenotype Associations	1.0	null
Adult Anaplastic Large Cell Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gamete generation	GO Biological Process Annotations 2015	1.0	null
liminal part of the r9 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08441
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
stomach	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC7614775-EMS178742-supplement-Proteomics_Table_1.pdf-112-GMEB2_GMEB2	Rummagene Transcription Factor Associations 2026	1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.623
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.541
GTEX-U3ZN-2626-SM-3DB7T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0514
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K67460571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25841
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K65182930_NVP-AUY922_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15312
Entorhinal area, lateral part, layer 2b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03622
BRD-K14117311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63652
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906009
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PH-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58133
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02878
BL5638 (AKAP13)	NURSA Protein Complexes	1.0	null
deubiquitinase activator activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55687
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
nucleus	GO Cellular Component Annotations 2015	1.0	null
abnormal germ cell morphology	MPO Gene-Phenotype Associations	1.0	null
COLO849	CCLE Cell Line Gene CNV Profiles	1.0	1.67188
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.79379
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAGLN2	Pathway Commons Protein-Protein Interactions	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PCMT1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K02329600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4553
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12916
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K02781189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02958
pontine raphe nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.882802
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.33697
Fanconi anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.874
MAP1S	Pathway Commons Protein-Protein Interactions	1.0	null
telenzepine-7419	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961454
pirinixic acid-495	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67364
9478_UBA1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501254
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6307_PHOX2B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519698
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97399
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62612
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247032
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26939
NF1 copy number variation syndrome 	WikiPathways Pathways 2024	1.0	null
9521_UBE2V2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510059
ubiquitin binding	GO Molecular Function Annotations 2025	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
LTBR_INHIBITION - 3 Day_GDS2004_735_mouse_Lymph nodes  (MG-430A)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K50216176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68224
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830652
Acute Myeloid Leukemia_LAML_TCGA-AB-2822-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3202	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883176
wortmannin-1081	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AOB, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48362
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K72050226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47398
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25986
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small gonad	MPO Gene-Phenotype Associations	1.0	null
hsa-miR-4643	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
reduced male fertility	MPO Gene-Phenotype Associations	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.639102
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22128
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE151083_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
partial embryonic lethality	MPO Gene-Phenotype Associations	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-124	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
ZNF730	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15401
BRCC3	Pathway Commons Protein-Protein Interactions	1.0	null
Ki-1+ Anaplastic Large Cell Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03292
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.574
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.862071
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856756
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZE-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06679
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.114
ChIP_YY1_21170310	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
T-cell acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.909
positive regulation of receptor signaling pathway via JAK-STAT	GO Biological Process Annotations 2025	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
Tubulin inhibitor 6_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0113921
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
PMC9038539-DataSheet1.docx-0-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
r10 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84448
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02261
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
c4ii	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58828
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.408226
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.596424
PAXIP1	Pathway Commons Protein-Protein Interactions	1.0	null
Fanconi anemia pathway	PID Pathways	1.0	null
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56618252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36055
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K14ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24594
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.75852
BRD-K35639494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78402
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6179
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34332
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A23R-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82863660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06751
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
PDXK	Pathway Commons Protein-Protein Interactions	1.0	null
troleandomycin-1965	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872414
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.953055
SKNBE2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.394
KAT2A	ENCODE Transcription Factor Targets	1.0	null
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAM175B	Pathway Commons Protein-Protein Interactions	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54029
CTCF-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary motor area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25828
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16792
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03624
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.931585
BRD-K52881132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21172
HCV JFH-1_12Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.81883
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.44035
Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
contain	GeneRIF Biological Term Annotations	1.0	null
BRD-K47349869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22046
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52811
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7211-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BL-41 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.647
dyclonine-7423	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1436	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.25958
BRD-K13849122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72878
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.858211
Limb Hypertonia	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38141
GSE104022_3_v_4_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258144
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47707657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08057
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SUCLG2	Pathway Commons Protein-Protein Interactions	1.0	null
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.57018
BRD-K85917058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28724
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283901
GB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5470-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KDM6A	ChEA Transcription Factor Targets	1.0	null
superficial stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1202
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904407
HERC2	Pathway Commons Protein-Protein Interactions	1.0	null
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292782
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.888
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A19500257_geldanamycin_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SNOS-0526-SM-4DM54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34787
organ development	GO Biological Process Annotations 2015	1.0	null
Histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.354
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Central Serous Chorioretinopathy	DisGeNET Gene-Disease Associations	1.0	null
GTEX-R53T-0526-SM-3GADL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28166
Proteasome core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.299
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78400597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59151
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K66214486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32058
TERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74261
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7652-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1	ChEA Transcription Factor Targets	1.0	null
EIF3A	Pathway Commons Protein-Protein Interactions	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.582525
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K23960050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44848
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75246
hsa-miR-890	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7015-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3201	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28011
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15427
K562_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167572
hydrastine hydrochloride-1740	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.246799
GTEX-S341-1326-SM-4AD72	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967574
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.84265
lytic vacuole	GO Cellular Component Annotations 2015	1.0	null
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.951485
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
BRD-K10343715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05954
JSC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anteroventral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04685
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52859120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08699
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	1.44326
TRIM33	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14659
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE146982_3_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8010105-41598_2021_86504_MOESM2_ESM.docx-0-CENPS_CENPS	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20869
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83787
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49078
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.70995
RAB1A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25396
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dorsal motor nucleus of the vagus nerve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45127
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951063
SEC24C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K08715020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84074
B95-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
NFIA_Deficiency_GDS2775_640_mouse_Postnatal brains (at P16)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
dexamethasone_homo sapiens_gpl6244_gse20963	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.6009
supramammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.90636
CSNK2A1	Hub Proteins Protein-Protein Interactions	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K75584297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8512
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.92864
homeostatic process	GO Biological Process Annotations 2015	1.0	null
BRD-K11782435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72167
WDR41	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.45
chr3_39133513_C_T_b38	GTEx eQTL 2025	1.0	1.12243
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31435
AC-49-ZR23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.404303
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K17765399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98865
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08849
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.977166
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
U2AF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.336
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.476506
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950879
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
DNA Damage Bypass	Reactome Pathways 2024	1.0	null
HT1080	BioGPS Cell Line Gene Expression Profiles	1.0	1.27889
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52661
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4568_KO_Prmt1_SRP178236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.50785
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
sirolimus-5239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JUND_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.888023
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29561
RPL11	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85951787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82904
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ubiquitin binding	GO Molecular Function Annotations 2023	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
RBBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02408
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071202
20012501-Table2	GeneSigDB Published Gene Signatures	1.0	null
SC-560-6913	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923976
Liver hepatocellular carcinoma_LIHC_TCGA-LG-A9QC-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
hsa-miR-206	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
BRD-K24143478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07258
BRD-K77978259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83963
double-strand break repair via homologous recombination	GO Biological Process Annotations 2025	1.0	null
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12037
Proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.091
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15206
BRD-K38966099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72062
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.05326
multi-organism cellular process	GO Biological Process Annotations 2015	1.0	null
CA46	CCLE Cell Line Gene Expression Profiles	1.0	1.62486
H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0368
NC-27-AD53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246594
r10 part of vagal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40951
positive regulation of cell proliferation	GO Biological Process Annotations 2015	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36108
BRD-K24206299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03495
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.681
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GFAP	Pathway Commons Protein-Protein Interactions	1.0	null
endosome	LOCATE Curated Protein Localization Annotations	1.0	null
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85887470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65401
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K80240487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55912
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01747
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45737
BRD-K47271260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58885
U2-OS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.771
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_14938_KD_Ptbp1_SRP053095	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.14923
Partial androgen insensitivity syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
BRD-K61092554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8766
decreased oocyte number	MPO Gene-Phenotype Associations	1.0	null
STAT4-19710469-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K13646706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20572
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45139
BRD-A39996500_radicicol_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K88504000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48204
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891207
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TERF2	Pathway Commons Protein-Protein Interactions	1.0	null
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5958
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
TUBA4A	Pathway Commons Protein-Protein Interactions	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
MAP1A	Pathway Commons Protein-Protein Interactions	1.0	null
DNA damage response	GO Biological Process Annotations 2025	1.0	null
CAL33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92789
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81810589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59693
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.968061
hsa-miR-3921	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K12226398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34001
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TET1-21451524-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.647
Acute Myeloid Leukemia_LAML_TCGA-AB-2816-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K43918582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7294
Sarcoma_SARC_TCGA-IW-A3M4-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QVUS-0626-SM-447CC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843341
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23914
KMS-12-BM	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.92044
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.957341
BRD-K78169765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18884
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05806
TCF12	ENCODE Transcription Factor Targets	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9516
b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.138698
BRD-K76611906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15861
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958052
8185_SMNDC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.524501
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.234
ZBTB33	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JQ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883191
positive regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2025	1.0	null
BRD-K99728124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36903
A431	GDSC Cell Line Gene Expression Profiles	-1.0	-1.80586
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02644
growth/size/body phenotype	MPO Gene-Phenotype Associations	1.0	null
Flocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3643
ELF1	ENCODE Transcription Factor Targets	1.0	null
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22038
BRD-K42754852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02373
BRD-K93488589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62687
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0416
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060235
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848806
Brain ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K10176883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01219
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04732
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.26648
FAM83D	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07281036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96812
NFYB	ENCODE Transcription Factor Targets	1.0	null
sirolimus_homo sapiens_gpl6244_gse15703	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7580-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14317
BRD-K54453373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88212
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LSM2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9946
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76662
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.96401
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RTCB	Pathway Commons Protein-Protein Interactions	1.0	null
BACH1	Pathway Commons Protein-Protein Interactions	1.0	null
Monogenic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.865
embryonic growth retardation	MPO Gene-Phenotype Associations	1.0	null
Primary motor area, Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27409
cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K65789952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1476
BRD-K98637033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06493
Rad51C-XRCC3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.689
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.47234
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74482064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59798
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
BRD-K61821542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42215
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
hsa-miR-656	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87515
BRD-K26232524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21
TRPM7_overexpression_305_GSE23102	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.09016
PMC10181932-41588_2023_1366_MOESM4_ESM.xlsx-Supplementary_Table_2-Supplementary_Table_2_Additional_information_for_all_SOX9-dependent_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69521416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1324
18757322-TableS1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K11577431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42845
UPF2	Pathway Commons Protein-Protein Interactions	1.0	null
Checkpoint clamp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.54
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05757
BRD-K14139166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26054
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.298371
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.49
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33807
BRD-K46623934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14406
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastric antrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.834
MutLalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3807
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hek293	HPA Cell Line Gene Expression Profiles	1.0	1.12719
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46985
acenocoumarol-1394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922863
Retina	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WDR70	Pathway Commons Protein-Protein Interactions	1.0	null
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.939921
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC50B_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.94558
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.907927
NCI-H2227	GDSC Cell Line Gene Expression Profiles	1.0	1.87623
lymphoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.100199
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30274
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853311
BL4505 (SMARCAD1)	NURSA Protein Complexes	1.0	null
FBXL7	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7235-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCNH2	Pathway Commons Protein-Protein Interactions	1.0	null
sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.478258
RPRD1A	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89638177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02281
Fanconi anemia complementation group T	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.757
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
loperamide-2033	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210770_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
TAF15	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-5595-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97748753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29779
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.302
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07401
GSE206342_1_v_0_kpna2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.968745
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063524
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE128730_3_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25784
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SET	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18070214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14766
Multiple myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.28
abnormal male reproductive gland morphology	MPO Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5559-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87080232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78536
positive regulation of receptor signaling pathway via STAT	GO Biological Process Annotations 2025	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.997712
XRN2	ChEA Transcription Factor Targets	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40007
BARD1	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA1L	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202879
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06308
RAB23	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K80877725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16751
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43381631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05991
BRD-K36812047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58159
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.757933
ITGA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523441
15474998-tableS1c	GeneSigDB Published Gene Signatures	1.0	null
BRD-K72721410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84362
TARBP1	Pathway Commons Protein-Protein Interactions	1.0	null
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
specific	GeneRIF Biological Term Annotations	1.0	null
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.969904
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.58069
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.388
EIF3H	Pathway Commons Protein-Protein Interactions	1.0	null
reduced fertility	MPO Gene-Phenotype Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.880622
BRD-K31110422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03502
PPP2CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15842
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC19A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566526
SW1990_PANCREAS	CCLE Cell Line Proteomics	1.0	7.31816
NRD1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3774-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16339
Acute leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
HS944T	CCLE Cell Line Gene CNV Profiles	1.0	1.34257
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74661
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945249
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4498	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
MAST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24895
layer 2 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.31643
AU565	CCLE Cell Line Gene CNV Profiles	1.0	1.47103
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.862727
NCI-H1993	GDSC Cell Line Gene Expression Profiles	-1.0	-2.99057
PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K39978929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36262
ANAPC10	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AMO1	CCLE Cell Line Gene Expression Profiles	1.0	1.63173
STK3	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r4 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00647
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.018
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.61111
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41652
BRD-K24369860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14235
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.562042
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.86676
BRD-K42575648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2073
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5153-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100515_HIP_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41124
GTEX-NPJ8-2226-SM-3TW8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13711
Childhood Leiomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	1.0	1.48737
hsf1_17216044_hela_lof_human_gpl571_gds1733	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.020739
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
regulation of protein modification process	GO Biological Process Annotations 2015	1.0	null
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAP1B	Pathway Commons Protein-Protein Interactions	1.0	null
cobalt chloride-454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-NFKB1_NFKB1	Rummagene Transcription Factor Associations 2026	1.0	null
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06754
SF3B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060495
BRD-K18290923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89734
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.808
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043077
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CDC23	Pathway Commons Protein-Protein Interactions	1.0	null
DUBm complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.788
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HPBALL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40647
subsequently	GeneRIF Biological Term Annotations	1.0	null
BRD-K06403738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61418
hsa-miR-613	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67672
assembles	GeneRIF Biological Term Annotations	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81D-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC16A1	Pathway Commons Protein-Protein Interactions	1.0	null
Spastic ataxia 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07627
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSP90AB2P	Pathway Commons Protein-Protein Interactions	1.0	null
PA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07041
AHSA1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289372
BRD-K20185935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24253
GTEX-XV7Q-0005-SM-4BRWI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00063
TSNAX	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.966895
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K35727000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75783
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23748
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal male genitalia morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K89216747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45197
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TD-09-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279984
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72767
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K78315404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06598
BRD-K46913557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3906
JUP	Pathway Commons Protein-Protein Interactions	1.0	null
AH-23848-6890	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921308
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04121
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.1076
BRD-K30566330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19886
BRD-K09972656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4624
CREM	ChEA Transcription Factor Targets	1.0	null
SDF4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872342
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.35213
DNAJC10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28924192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39312
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45599
localization	GeneRIF Biological Term Annotations	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4762
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01565
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01311
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.838
GTEX-QV44-0826-SM-2S1RG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930436
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6088-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23204256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05053
BRD-K41396351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33992
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23361743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59835
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
T84	CCLE Cell Line Gene CNV Profiles	1.0	1.94739
required	GeneRIF Biological Term Annotations	1.0	null
Protein phosphatase 4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.854
Primary motor area, Layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0408
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52929
Lewis lung carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
DNA recombinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.654
colon	HPA Tissue Protein Expression Profiles	1.0	0.750846
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3175	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914661
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14409
Perturb_18144_KO_Fxr/Shp_SRP152043	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.0159
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063791
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12916
Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20501114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44774
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSPA7	Pathway Commons Protein-Protein Interactions	1.0	null
4939_MED17_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15986
BRD-K67535324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12936
BRD-K02060635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6923
hsa-miR-3173-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
PMC12394622-41698_2025_1096_MOESM1_ESM.docx-0-SOX2_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
17009876-tableS3b	GeneSigDB Published Gene Signatures	1.0	null
XRN2-22483619-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00073
Polycystic Ovary Syndrome_Skeletal muscle_GSE6798	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.53756
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
dt-40 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.20689
GSE147240_3_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86002795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56879
lateral hypothalamic area, tuberal region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0425
TUBA1A	Pathway Commons Protein-Protein Interactions	1.0	null
reduced male fertility	MGI Mouse Phenotype Associations 2023	1.0	null
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50149
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.98552
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13017
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA2-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11305
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.943516
SLC9A3R2	Pathway Commons Protein-Protein Interactions	1.0	null
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.7369
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901442
MXI1	ENCODE Transcription Factor Targets	1.0	null
496100406_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.52026
posterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05066
TMED10	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7861-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14268329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41358
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40314
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.82322
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41937
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93035
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXC9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24474
periventricular stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41124
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K08576275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3712
GTEX-RM2N-0526-SM-2TF4N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42454
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.6615
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PSMA3	Pathway Commons Protein-Protein Interactions	1.0	null
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
uaf1	GeneRIF Biological Term Annotations	1.0	null
MAP7D2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.36045
BRD-K56857396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07358
Perturb_6594_KO_Mfn1_SRP189311	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.96084
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836949
abnormal gametogenesis	MPO Gene-Phenotype Associations	1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16608
TRIM21	Pathway Commons Protein-Protein Interactions	1.0	null
496100644_HIP_probable Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.38679
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928387
DOK	GDSC Cell Line Gene Expression Profiles	-1.0	-2.08281
HuO-3N1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	4.09637
BRD-K78612514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39237
UBR5	Pathway Commons Protein-Protein Interactions	1.0	null
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52592
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.241895
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K10416099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37422
GTEX-XOTO-2126-SM-4B64U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02493
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.56649
BRD-K45289917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99355
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.10552
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04051
BL-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88635
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.37561
reveal	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-217	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
epidermis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64665523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20732
496100446_TCx_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00952
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342487
GTEX-QEL4-0326-SM-3GAE5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866984
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4092
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867952
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12473
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RN64-1026-SM-48FDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32174
MZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03437
BRD-K34264024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38798
SB-29-ZH97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22284
G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.941
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.538
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.893299
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56219
hsa-miR-4759	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61496
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883959
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
embryonic organ development	GO Biological Process Annotations 2015	1.0	null
GSE186483_6_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ICAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75037
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928802
melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857869
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F1-26619117-HEPATOCYTES-MOUSE-LIVER	ChEA Transcription Factor Targets 2022	1.0	null
inner CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00338
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
melanoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.40385
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5258-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216836
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10181
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52697
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14379
ciprofloxacin-2022	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K80073743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09696
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12584
BRD-K10900122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13526
SAFB2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4476	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
Vesicle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
superficial stratum of FCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40903
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.906845
Brain Lower Grade Glioma_LGG_TCGA-HT-A5RA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
SMN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.69
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
one	GeneRIF Biological Term Annotations	1.0	null
BCL7C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K20745677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59778
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z0-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neuroendocrine cell_Trachea_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.787134
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RWS6-0526-SM-4GIAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880046
Intracranial Aneurysm	DisGeNET Gene-Disease Associations	1.0	null
BRD-K12929741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69103
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.542259
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5067
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPTN	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rapamycin vs Ctrl_Exp2_MEFs (Mouse) [21659605]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	1.0	null
a431	HPA Cell Line Gene Expression Profiles	-1.0	-0.935017
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5988-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bladder	GTEx Tissue Gene Expression Profiles	1.0	1.26619
BCR	Pathway Commons Protein-Protein Interactions	1.0	null
ERBB2_druginhibition_6_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.54739
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
BRD-K03765511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92829
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.17376
Ventral tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24095
BRD-A17658676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13555
GTEX-OIZI-0426-SM-2XCEF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836124
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40738002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10947
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-11A-02R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H358 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
RPL38	Pathway Commons Protein-Protein Interactions	1.0	null
FIP1L1	Pathway Commons Protein-Protein Interactions	1.0	null
19841744-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32794
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05795
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18762
hsa-miR-4717-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.36161
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-11A-01R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
BRD-K29707171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66781
abnormal embryogenesis/ development	MPO Gene-Phenotype Associations	1.0	null
abnormal prenatal growth/weight/body size	MPO Gene-Phenotype Associations	1.0	null
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5694
CSE1L	Pathway Commons Protein-Protein Interactions	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.05225
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246779
Guanethidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.22
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14716
TRMT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03965
K562_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016615
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.7013
BEN	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.67865
Antral mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.92
ventrolateral part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02492
Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2948
Adrenocortical carcinoma_ACC_TCGA-OR-A5L8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Spastic ataxia 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270969
BRD-K33197627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39303
zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081964
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.127645
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12791
BRD-A19500257_geldanamycin_HME1_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20183
BRD-K79658624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04338
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5870_KD_Cpsf7_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.46605
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33935
HNRNPA3	Pathway Commons Protein-Protein Interactions	1.0	null
homeostasis of number of cells	GO Biological Process Annotations 2015	1.0	null
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.98274
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NP-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TGM3	Pathway Commons Protein-Protein Interactions	1.0	null
respectively	GeneRIF Biological Term Annotations	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
fanconi's anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.6543
RELA_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EN1	JASPAR Predicted Transcription Factor Targets	1.0	null
MOLT13	CCLE Cell Line Gene Expression Profiles	1.0	1.45445
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lysosome	GO Cellular Component Annotations 2015	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202589
BRD-K86228587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04305
GSE195559_2_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.6915
BRD-K02471501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43265
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13093
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21987
CTBP2	ENCODE Transcription Factor Targets	1.0	null
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CHAF1A	Pathway Commons Protein-Protein Interactions	1.0	null
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329192
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054494
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114258_3_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3827
KRT9	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r4 part of lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09988
GTEX-XMK1-1326-SM-4B65Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07056
hsa-miR-570	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.87548
FLI1	ChEA Transcription Factor Targets	1.0	null
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.536229
ARHGEF10	Pathway Commons Protein-Protein Interactions	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
Deubiquitination	Reactome Pathways 2024	1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.17728
GTEX-U3ZN-0326-SM-3DB86	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917129
LS513_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	3.78541
GTEX-SNMC-0826-SM-4DM66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972207
BRD-K87849910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18127
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45195
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of protein monoubiquitination	GO Biological Process Annotations 2015	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042199
NFKB1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95117
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.03828
BRD-K38073091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14294
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01107
d2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.197
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52679
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKBR3	CCLE Cell Line Gene CNV Profiles	1.0	2.66546
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Karyomegalic interstitial nephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.621
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7298
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.759455
Osteosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.686
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.539
layer 4 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75212
CEP55	Pathway Commons Protein-Protein Interactions	1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7669-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051626
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195	Rummagene Transcription Factor Associations 2026	1.0	null
epidermal cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07975
Kidney renal papillary cell carcinoma_KIRP_TCGA-PJ-A5Z8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PDHB	Pathway Commons Protein-Protein Interactions	1.0	null
SUP-B15	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.58868
SSRP1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF326	Pathway Commons Protein-Protein Interactions	1.0	null
CIDEC_KO_GDS3776_552_mouse_Brown and white adipose tissues	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8415-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K30633507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15751
Xeroderma pigmentosum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.639
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67104
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPLP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K37657049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23917
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55334
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17406
BRD-K64591035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18943
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57371
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.822377
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A7HU-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERLIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15791
FOXK2	Pathway Commons Protein-Protein Interactions	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BRD-K57404319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25562
CRCGN014_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4948
multicellular organism growth	GO Biological Process Annotations 2015	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.10403
Brain Lower Grade Glioma_LGG_TCGA-CS-4938-01B-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r9 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06373
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993091
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7714-01A-12R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HBB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17895
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6433-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EEF1G	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5463-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
8906_TIGD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544368
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.4258
547_ARRB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04245
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5499
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0939
SRSF7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13526564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48426
paclitaxel_rattus norvegicus_gpl890_gse5337	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CLTCL1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.833909
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76976010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10095
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
FOXP2_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.87938
hsa-miR-4727-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GPAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02405
A375	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2G	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4756-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
DNAJC9	Pathway Commons Protein-Protein Interactions	1.0	null
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6261
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
abnormal seminiferous tubule morphology	MGI Mouse Phenotype Associations 2023	1.0	null
L-428	GDSC Cell Line Gene Expression Profiles	1.0	2.72723
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934616
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.6872
CRCGN010_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.796
H2AK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thyroid gland	HPA Tissue Gene Expression Profiles	1.0	1.28008
GTEX-XYKS-0526-SM-4BRW2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932635
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MED8	Pathway Commons Protein-Protein Interactions	1.0	null
lateral habenular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.968156
NCI-H2342	GDSC Cell Line Gene Expression Profiles	-1.0	-2.23705
BRD-K31297909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43861
GTEX-QV31-0726-SM-3GAEG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886868
BRD-K87593103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07722
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.32221
decreased male germ cell number	MPO Gene-Phenotype Associations	1.0	null
ciclosporin-602	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K07160568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12421
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56058
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TML8-1626-SM-32QOO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17286
ntera2	HPA Cell Line Gene Expression Profiles	1.0	0.859246
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFG7-0326-SM-3GILI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877613
developmental process	GO Biological Process Annotations 2015	1.0	null
BRD-K02839126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16588
BRD-K99859971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00336
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
OSC-20	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.769
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
PA-1	GDSC Cell Line Gene Expression Profiles	1.0	1.70737
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Machado-Joseph disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.995
metitepine-1616	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATAD2A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10876937-41698_2024_528_MOESM2_ESM.pdf-10-XPA_XPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K28354175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01474
PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.677322
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3115
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K74677971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33952
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
intermediate stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20548
KAT2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sapanisertib_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0122227
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PCNA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.452
KRT4	Pathway Commons Protein-Protein Interactions	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.08194
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUL4B	Pathway Commons Protein-Protein Interactions	1.0	null
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.912336
IRF2	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K67830713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21227
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24759
BRD-K71871382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70844
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.09576
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNRPE	Pathway Commons Protein-Protein Interactions	1.0	null
RCH-ACV	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NPEPPS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58028568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52502
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21614
symbiosis, encompassing mutualism through parasitism	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.542
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.961452
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14383
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0726-SM-4DXT5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1441
trochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22576
usp46	GeneRIF Biological Term Annotations	1.0	null
FOXA1_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r9 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01797
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.928
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gastrula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.68188
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CIAO2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30493
ACTBL2	Pathway Commons Protein-Protein Interactions	1.0	null
RPS27	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944374
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HSC-4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.30786
SKNAS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5907
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9064
PHF8	ENCODE Transcription Factor Targets	1.0	null
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	2.0195
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.919677
jm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
STAT4	ChEA Transcription Factor Targets	1.0	null
GCN1L1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K25470159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27744
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K71216961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84378
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q734-0726-SM-48TZP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921991
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.17274
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NCIH1436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53886
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28597
BRD-K87803080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8893
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Narcolepsy	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.939882
T-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.47525
GTEX-U3ZN-1226-SM-4DXUD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0288
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81Q-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, lower limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0043
hsa-miR-4776-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.957341
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06308
Ribonuclease H2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.575
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93661
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8096
GTEX-WYVS-0326-SM-3NM9V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12719
P300-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PSDG-0726-SM-2I5FN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86244
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12374
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873834
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19761
largeintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.911774
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dna metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05409
SARS2	Pathway Commons Protein-Protein Interactions	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tonsil	HPA Tissue Protein Expression Profiles	-1.0	-1.01653
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12811
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATG7	Pathway Commons Protein-Protein Interactions	1.0	null
NOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614707
BRD-K90806964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27112
SLC25A5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K12431811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92087
Anterior cingulate area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55107
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BL1051 (N4BP2)	NURSA Protein Complexes	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.88064
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
three	GeneRIF Biological Term Annotations	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.893253
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCIM1	CCLE Cell Line Gene Expression Profiles	1.0	1.83857
BRD-K57937572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15432
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52141
PPP1R9B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54788
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.46883
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K60543885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4818
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27791
Ku70:Ku80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.745
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48324
BRD-K61886116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37186
BRD-K56716645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73212
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.20879
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.937586
BRD-K04883778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10141
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91135
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
YY1-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85767
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXC8	Pathway Commons Protein-Protein Interactions	1.0	null
KRT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.319
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81701
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53094
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446739
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.343
HUPT4	CCLE Cell Line Gene CNV Profiles	1.0	1.846
CAL-72	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5455-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JI-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fide	GeneRIF Biological Term Annotations	1.0	null
nes	HPA Cell Line Gene Expression Profiles	1.0	0.853233
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89143
HNF4A	ENCODE Transcription Factor Targets	1.0	null
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OVCAR8	BioGPS Cell Line Gene Expression Profiles	1.0	0.870061
double-strand break repair	GO Biological Process Annotations 2015	1.0	null
HDLM-2	GDSC Cell Line Gene Expression Profiles	1.0	2.00249
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11594
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
GTEX-S3XE-1226-SM-4AD4L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839447
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8831
SEC24B	Pathway Commons Protein-Protein Interactions	1.0	null
complexes	GeneRIF Biological Term Annotations	1.0	null
6455_PLK4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.519681
reproductive process	GO Biological Process Annotations 2015	1.0	null
retina	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60295429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42214
GSE195559_3_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3168_OE_Rbfox2_SRP186301	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.25414
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYB_01_44	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61457
BRD-K67563379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31948
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.72985
Recognition of DNA damage by PCNA-containing replication complex	Reactome Pathways 2024	1.0	null
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04865
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10535
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.61353
lytic vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.212974
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
ATG4B	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.346
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00159
A704	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50326
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BL6507 (FBXO28)	NURSA Protein Complexes	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6510-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Orbital area, medial part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07401
Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.00134
HNRNPUL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28057105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34707
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.467
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4163
BRD-K51272331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66578
Brain Edema	CTD Gene-Disease Associations	1.0	1.0189
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54724
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20434
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
pallidohypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.871711
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318989
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16543
hsa-miR-4778-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
HIPK2_overexpression_28_GDS4233	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.42695
MARCHF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58135
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Fanconi anemia pathway	KEGG Pathways 2026	1.0	null
BRE	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33436
small testis	MPO Gene-Phenotype Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4424-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38084509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27202
BRD-K06863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06747
DSC1	Pathway Commons Protein-Protein Interactions	1.0	null
undifferentiated	GeneRIF Biological Term Annotations	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEPT9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4521181-oncsis201520x8.pdf-16-ZNF292_ZNF292	Rummagene Transcription Factor Associations 2026	1.0	null
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.9776
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5454-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-39-ZQ15_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334662
CBX3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7590-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68497273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77003
H4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.15035
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RSL1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44275
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
SURF2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K96054771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37395
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.216977
ovary	HPA Tissue Protein Expression Profiles	-1.0	-2.00846
Entorhinal area, lateral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22881
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
LNCAP	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.881069
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3328
USP46	Pathway Commons Protein-Protein Interactions	1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.29907
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Gracile nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35945
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DMS454	CCLE Cell Line Gene CNV Profiles	-1.0	-2.55157
Protein of unknown function DUF3337	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-A19500257_geldanamycin_HME1_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53027
BRD-K31778735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16457
ARCN1	Pathway Commons Protein-Protein Interactions	1.0	null
FLNB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05250921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37364
BRD-K81888673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46517
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
viral process	GO Biological Process Annotations 2015	1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4035
abnormal female reproductive system physiology	MPO Gene-Phenotype Associations	1.0	null
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916674
PFAS	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5458-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0572
BRD-K09071517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55731
IWS1	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
MutSalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.865
TUBGCP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04243
GTEX-NPJ8-0426-SM-2HMK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09079
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
TOV-21G	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.84087
GSE232472_1_v_2_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
skin cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74249
MAFK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05193
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rhp55-Rhp57 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.303
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.53292
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-DX-A48U-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13472433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14538
Lung adenocarcinoma_LUAD_TCGA-78-7155-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_JARID1A_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CCDC59	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MSX1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prelimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68844
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368524
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nonhomologous end joining complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.195025
FOXA1-21915096-LNCAP-1F5-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SNRPD3	Pathway Commons Protein-Protein Interactions	1.0	null
FASN	Pathway Commons Protein-Protein Interactions	1.0	null
Fanconi anaemia nuclear complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.86
Brivudine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0298085
efficient	GeneRIF Biological Term Annotations	1.0	null
XPC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
reduced female fertility	MGI Mouse Phenotype Associations 2023	1.0	null
RPL22	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6779
KLF16	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43388152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31429
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63921431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56149
GSE123943_4_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r2BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23268
NCIH2085	CCLE Cell Line Gene CNV Profiles	1.0	2.79336
diclofenac-445	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HeLa-S3 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.29461
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.198325
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_DDR_Genes_NOT_HNSCCHNSCC_DDP_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.87938
RPS3	Pathway Commons Protein-Protein Interactions	1.0	null
SCF-Cdc4 ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.693
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
cytoplasm	GeneRIF Biological Term Annotations	1.0	null
SHMT1	Pathway Commons Protein-Protein Interactions	1.0	null
BET1	Pathway Commons Protein-Protein Interactions	1.0	null
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
AC-47-YZ27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317556
BRD-K19710723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36359
1843_CPSF4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.553811
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
developmental process involved in reproduction	GO Biological Process Annotations 2015	1.0	null
SH3GLB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0253
CLDN15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20488
BRD-K05639803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1515
GINS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.365
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
dna repair	GO Biological Process Annotations 2015	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03778
GTEX-UJMC-0326-SM-3GAE2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02312
pravastatin-lactone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19887
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Nucleus of the solitary tract, commissural part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16026
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2023	1.0	null
BRD-K00231307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37261
single fertilization	GO Biological Process Annotations 2015	1.0	null
abnormal skin physiology	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K63761383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37245
double-strand break repair via homologous recombination	GO Biological Process Annotations 2023	1.0	null
Perturb_14568_KO_Got2_SRP348541	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.68689
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.762
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47664
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18799
thalidomide-606	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
BRD-K13852343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33016
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04806
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LB-90-DC89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231881
Prostate-epithelial cell	Tabula Sapiens Gene-Cell Associations	1.0	9.95429
SK-ES-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.665
DNA polymerase III, clamp loader complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.914
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19065
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE87144_3_v_1_rorc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1285
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
trimetazidine-1727	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HEK 293T	BioGPS Cell Line Gene Expression Profiles	1.0	1.5332
Axillary bud meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.087
15220918-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-762	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
ChIP_CTCF_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.893095
keratinocytes	GeneRIF Biological Term Annotations	1.0	null
PKM	Pathway Commons Protein-Protein Interactions	1.0	null
GSE198165,GSE198166_9_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleus x	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55983
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE205316,GSE205317_2_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PDHK3	Kinase Library Tyrosine Kinome Atlas	1.0	98.6
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of receptor signaling pathway via JAK-STAT	GO Biological Process Annotations 2025	1.0	null
r10 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93158
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3456-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152055
PMC3669416-pone.0064838.s001.xls-mHTT-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE147943_4_v_6_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978001
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.858211
lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089481
ALDH16A1	Pathway Commons Protein-Protein Interactions	1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
16207381-Table1Sa	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38253
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
SNRPA	Pathway Commons Protein-Protein Interactions	1.0	null
RAB10	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42782
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75235
BRD-K08618283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44694
BRD-K09112411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41014
hsa-miR-137	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE140651,GSE140653_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBB_KO_GDS3906_492_mouse_Testis -  14 Days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
POLR2A_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-2526-SM-3DB7V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988949
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.72199
DNA replication factor A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.273
PMC3669416-pone.0064838.s001.xls-mHTT-HOXD11_HOXD11	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.605
minoxidil-1996	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4676-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5549-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
P4HA2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77403813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34885
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5546-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30148
A204	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.95496
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21316
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-1587	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14766
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25741
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78218
K562_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155006
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
trichostatin A-1561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
integument phenotype	MPO Gene-Phenotype Associations	1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
prostate gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.303198
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17837
HH	GDSC Cell Line Gene Expression Profiles	1.0	2.48082
embryonic lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
BABAM1	Pathway Commons Protein-Protein Interactions	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.572398
hsa-miR-4797-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BRD-K04251837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77198
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARL8B	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal reproductive system physiology	MPO Gene-Phenotype Associations	1.0	null
SLC9A3R1	Pathway Commons Protein-Protein Interactions	1.0	null
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37474
HUWE1	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1795
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.713507
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
serves	GeneRIF Biological Term Annotations	1.0	null
Proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.357
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K56384677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02943
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42647
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17245
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053702
BRD-K06220918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13963
Perturb_15642_KD_Sf3a1_SRP043160	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.37262
superficial stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.25633
non-syndromic X-linked intellectual disability 99	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
Oligospermia	CTD Gene-Disease Associations	1.0	1.05052
hsa-miR-193a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAMHD1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60828476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85102
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
MAZ	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24025166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13561
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133673
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.177839
regulation of protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7473-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27168
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
ASH2L	Pathway Commons Protein-Protein Interactions	1.0	null
DNA polymerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.884
KRT75	Pathway Commons Protein-Protein Interactions	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.61001
PPP5C	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB2	Pathway Commons Protein-Protein Interactions	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066021
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SAGA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.575
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02278
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77883
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64515
A253	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 5 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34449
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.90483
BRCA1	ENCODE Transcription Factor Targets	1.0	null
BRD-K16331797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93384
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5641-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Toremifene Citrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113736
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.70832
Malignant Fibrous Histiocytoma	DisGeNET Gene-Disease Associations	1.0	null
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW1271	CCLE Cell Line Gene CNV Profiles	1.0	1.49163
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04544693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5057
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51146
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THOC2	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28731
BRD-K03624299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06652
form	GeneRIF Biological Term Annotations	1.0	null
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14725
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00016
UNC13B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09838
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fendiline-1573	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7723
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20157822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06486
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.569
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K91588908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00113
IRF4	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4738-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
b-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.672913
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.551258
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.15776
Bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.651
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967774
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TGFBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1269
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCOR1	Pathway Commons Protein-Protein Interactions	1.0	null
CAMSAP3	Pathway Commons Protein-Protein Interactions	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52609
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7148
morula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087635
double-stranded DNA binding	GO Molecular Function Annotations 2023	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15709
Hereditary spastic paraplegia 43	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
estradiol-782	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69717
BRD-K68298468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38909
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04094
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38142
hsa-miR-506	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64862162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08177
BRD-K96295480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11531
PLS3	Pathway Commons Protein-Protein Interactions	1.0	null
CDC37	Pathway Commons Protein-Protein Interactions	1.0	null
HCV JFH-1_48Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.48414
regulating	GeneRIF Biological Term Annotations	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0438
organelle	GO Cellular Component Annotations 2015	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30437
TIMM17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33581
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07152092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00848
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06411
GSE246053_4_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
skeletal muscle cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.593247
mortality/aging	MPO Gene-Phenotype Associations	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04297
GTEX-QMR6-1926-SM-32PL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08751
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.75605
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IK-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17886576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61492
GTEX-U4B1-0626-SM-3DB8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03898
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061078
CSNK2B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMC loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.38
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YS-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K57830670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89673
AHCYL1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32832
hsa-miR-1178	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
lateral hypothalamic area, anterior region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.918581
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19687
abnormal female germ cell morphology	MPO Gene-Phenotype Associations	1.0	null
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16976282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16034
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K31852848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92147
BRD-K67980271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16361
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00829
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.895824
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.998798
PRKCI	Pathway Commons Protein-Protein Interactions	1.0	null
Diseases of signal transduction by growth factor receptors and second messengers	Reactome Pathways 2024	1.0	null
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	1.0	null
MET_knockout_247_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.89689
SEC16A	Pathway Commons Protein-Protein Interactions	1.0	null
LMO2-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
XRN2-22483619-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
KRT1	Pathway Commons Protein-Protein Interactions	1.0	null
outer CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06553
HGC-27	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.36461
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17067
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07402
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Upregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
BRD-K72754669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18724
18757322-TableS3	GeneSigDB Published Gene Signatures	1.0	null
peptidase activator activity	GO Molecular Function Annotations 2025	1.0	null
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
DAZAP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K84636055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51603
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
AF-00-QK19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291712
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSU	CCLE Cell Line Gene CNV Profiles	1.0	2.24633
BRD-K36726853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10345
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31702
PAIP1	Pathway Commons Protein-Protein Interactions	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT4-19710469-TH1 cell mouse-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17555
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
hsa-miR-320e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Perturb_1238_KD_SRSF1_SRP033393	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.67738
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.902253
b95.8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
GLTSCR2	Pathway Commons Protein-Protein Interactions	1.0	null
KRT71	Pathway Commons Protein-Protein Interactions	1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K73500713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06305
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.265
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K89935890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19262
BL1425 (FOXO1)	NURSA Protein Complexes	1.0	null
FOXA1-25552417-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.997712
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985707
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GIPC1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EPHA4_knockout_227_GSE34430	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.15584
GTEX-OIZH-0726-SM-3NB1I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903513
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04881
coimmunoprecipitation	GeneRIF Biological Term Annotations	1.0	null
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935703
GC-74-QF56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228002
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73573090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19473
Sympodium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345247
Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HOXA9	Pathway Commons Protein-Protein Interactions	1.0	null
NUP50	Pathway Commons Protein-Protein Interactions	1.0	null
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0665
RNA polymerase I upstream activating factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.174
BRD-K23405293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32055
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041168
dorsal part of m2A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1708
NELFE	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5761-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
HIST1H1D	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K16154498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19492
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
canthaxanthin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05638
SMARCB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K63145472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41033
BRD-K95922469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04931
BRD-K93516545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23931
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
PAICS	Pathway Commons Protein-Protein Interactions	1.0	null
PJA2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853656
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Origin recognition complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94708
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6470-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Orbital area, ventrolateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54743
Perturb_7239_KO_CDK8_SRP271652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11356
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.439
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.68
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042229
abnormal primary sex determination	MPO Gene-Phenotype Associations	1.0	null
GTEX-U3ZN-0126-SM-4DXUM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857624
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4012
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874878
BRD-K76951235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05928
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02159
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53262
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC257	CCLE Cell Line Gene Expression Profiles	-1.0	-2.17949
r9 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26488
BRD-K39526528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12178
BRD-K21356734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35951
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WD40 repeat	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K84949119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76837
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMMC-7721 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18369
BRD-K79322550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77401
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.171149
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
Testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K20735575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46025
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
tube development	GO Biological Process Annotations 2015	1.0	null
Lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.695
anatomical structure morphogenesis	GO Biological Process Annotations 2015	1.0	null
hsa-miR-431	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE176008_8_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPM-2626-SM-33HC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76145
multi-organism process	GO Biological Process Annotations 2015	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.80726
BRD-K97330035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53406
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4754
CAL27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4278
lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.213322
BRD-K13859368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36932
BRD-K90138084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76038
Somatomotor areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56841
Leukoplakia of penis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
abnormal oocyte morphology	MPO Gene-Phenotype Associations	1.0	null
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.7259
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF3A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67382
GTEX-WYVS-1726-SM-3NMAY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06757
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-5155-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01814
c-33a cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.948239
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
BRD-K92949288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04391
PK1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05477
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC7244323-elife-55325-supp3.xlsx-Haapaniemi_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28251
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1101
BRD-K56041932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45178
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G-protein beta WD-40 repeat	InterPro Predicted Protein Domain Annotations	1.0	null
HEY1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K46428124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38903
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SC-100432 (MAK)	NURSA Protein Complexes	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DNA Repair	Reactome Pathways 2024	1.0	null
Xeroderma pigmentosum variant type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.58
DNA replication factor C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.595
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
lymphoblastoid cell line	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.80908
MMP2	Pathway Commons Protein-Protein Interactions	1.0	null
deubiquitinase activator activity	GO Molecular Function Annotations 2025	1.0	null
r9 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1146
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17344
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68632
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33266
HIPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0404
MYC-20876797-MEDULLOBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K89432538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49584
vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K97540907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05502
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
papillomavirus	GeneRIF Biological Term Annotations	1.0	null
valproic acid_homo sapiens_gpl96_gds1050	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K91506006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07194
CALML5	Pathway Commons Protein-Protein Interactions	1.0	null
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.985016
NCIH1792	CCLE Cell Line Gene CNV Profiles	1.0	1.70479
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EW-11	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.94579
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064721
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859546
NUP155	Pathway Commons Protein-Protein Interactions	1.0	null
BRCA1_DEPLETION_GDS3791_38_human_Hela	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PEF1	Pathway Commons Protein-Protein Interactions	1.0	null
NUP210	Pathway Commons Protein-Protein Interactions	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281533
TARDBP_KD_GDS3730_118_human_HEK293E	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10896
HNRNPH2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41604824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18363
TAF7	ENCODE Transcription Factor Targets	1.0	null
BRD-K40494117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65242
NCIH647	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56554
LGI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01865
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TTC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33402
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K15236933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11669
BRD-K98145661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19766
NCIH28	CCLE Cell Line Gene CNV Profiles	1.0	1.60357
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20448
hsa-miR-4773	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-QEG5-1426-SM-447AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941801
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.42
GTEX-REY6-1026-SM-2TF4Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945893
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15426523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65643
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09044
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.912336
NAF1	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal sex gland morphology	MPO Gene-Phenotype Associations	1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78656517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08193
regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2025	1.0	null
DD-74-PJ26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273789
CTCF	ChEA Transcription Factor Targets	1.0	null
MK-886-601	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
THYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06194
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	2.2783
Replication fork protection complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.119
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BL6185 (USP1)	NURSA Protein Complexes	1.0	null
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
arachidonyltrifluoromethane-327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
sleep disorder	GWASdb SNP-Disease Associations	1.0	1.55627
ARL1	Pathway Commons Protein-Protein Interactions	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150082
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.04366
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SU-DHL-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCCPAN2_PANCREAS	CCLE Cell Line Proteomics	1.0	3.72735
diflunisal-1990	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
residue	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.24179
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.912336
abnormal testis size	MPO Gene-Phenotype Associations	1.0	null
GTEX-N7MT-0126-SM-2D7VT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10489
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44668
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.87938
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02298
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13609
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-520h	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K27228812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13857
PMC10959942-41525_2024_411_MOESM1_ESM.pdf-12-SOX11_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54672
JURKAT cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.871517
STK4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
Site of DNA damage	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.713
Impaired Vibration Sensation In The Lower Limbs	DisGeNET Gene-Phenotype Associations	1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Nuclear chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.711
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.038
blastula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088767
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993366
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
tretinoin-447	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.12533
superficial stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48517
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.160053
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.787236
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5442-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13085116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13728
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176163
PRDX3	Pathway Commons Protein-Protein Interactions	1.0	null
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06790927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75231
BRD-K00048792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0149
GSE131649_4_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15285842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.50877
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36498
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE-520	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.2278
hsa-miR-4793-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
Anterior cingulate area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69054
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.79482
dna replication factor c complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.784614
KMRC20	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78113
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14468
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.842159
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.057
KDM5A	ENCODE Transcription Factor Targets	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076724
BUD31	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571952
AKT1_knockout_215_GSE39699	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.52236
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mild Mental Retardation	DisGeNET Gene-Disease Associations	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.312
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929257
BRD-K63394284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05605
PMC12289921-41467_2025_62099_MOESM4_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6668-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-79-SX47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367043
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48052
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2042
A-CA-04-2009(H1N1)_6Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.36858
BRD-K89744662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33699
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62878
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58888
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.361155
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98333
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rad17 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.21
DUSP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19107
PRPF31	Pathway Commons Protein-Protein Interactions	1.0	null
UTP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96201
BRD-K23164928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36768
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_1-Supplemental_Table_S1_1_Genes_significantly_downregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14070721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05077
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07029
seminiferous tubule development	GO Biological Process Annotations 2015	1.0	null
GTEX-X5EB-2626-SM-4E3HZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878381
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907281
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
icSARS CoV_0Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.95963
Ino80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.978
LY-294002-1074	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62807053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96103
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534553
hsa-miR-4417	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.976403
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE249098_3_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
preweaning lethality	MPO Gene-Phenotype Associations	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.907099
Fanconi Anemia Pathway	Reactome Pathways 2024	1.0	null
nucleus	GeneRIF Biological Term Annotations	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.11363
FKBP5	Pathway Commons Protein-Protein Interactions	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC7244323-elife-55325-supp3.xlsx-This_paper_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57464717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42958
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.542
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81899
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45143
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226225
GTEX-VJYA-0426-SM-3GIJK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91392
CBX3	ENCODE Transcription Factor Targets	1.0	null
Anterior olfactory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02019
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
p3hr1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914339
RPL30	Pathway Commons Protein-Protein Interactions	1.0	null
GSE137818_5_v_0_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
DYNC1LI1	Pathway Commons Protein-Protein Interactions	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0833
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959091
Kidney renal papillary cell carcinoma_KIRP_TCGA-UN-AAZ9-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041584
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03778
SF295	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.831316
Perturb_4278_KO_Nr2f1_SRP149321	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.35249
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058939
PDK1_knockout_80_GSE26290	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.29519
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83693
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982641
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15399
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75220555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33897
BRD-K53387776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08986
AR-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
manner	GeneRIF Biological Term Annotations	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53666
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K71538933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0743
hsa-miR-4756-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
RBBP5	ENCODE Transcription Factor Targets	1.0	null
skeletal muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.118334
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YT-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r10 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75489
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CJUN-26792858-CHIP-SEQ-BT549-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K80535598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24421
GTEX-SNMC-1326-SM-2XCFK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06781
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.837218
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45442
PMC7825356-8844261.f3.docx-247-NR1D2_NR1D2	Rummagene Transcription Factor Associations 2026	1.0	null
DDX41	Pathway Commons Protein-Protein Interactions	1.0	null
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC39A13_Deficiency_GDS3485_570_mouse_Chondrocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
protein modification process	GO Biological Process Annotations 2015	1.0	null
CAD	Pathway Commons Protein-Protein Interactions	1.0	null
TJP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29748
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	Reactome Pathways 2024	1.0	null
SRI	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal embryonic growth/weight/body size	MPO Gene-Phenotype Associations	1.0	null
GTEX-PWCY-1426-SM-48TCT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835566
BRD-K76960970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59871
C11orf58	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K49755501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41721
Accessory olfactory bulb, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13769
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02714
GPN3	Pathway Commons Protein-Protein Interactions	1.0	null
r9 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21813
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BL3509 (KDM4A)	NURSA Protein Complexes	1.0	null
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920654
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	0.925825
decreased birth weight	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K08806664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7772
SPTBN1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.28027
HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trachea	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
embryonic lethality during organogenesis, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.832466
ETS1	ENCODE Transcription Factor Targets	1.0	null
BRD-K14570970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93545
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K57084585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02191
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIAL1	Pathway Commons Protein-Protein Interactions	1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.91236
BRD-K45569026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26507
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67069
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRN-1726-SM-3NM9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18359
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic growth retardation	MGI Mouse Phenotype Associations 2023	1.0	null
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26399271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15788
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35253
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934658
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.93605
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-1.01653
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal male reproductive system physiology	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RN64-0526-SM-2TC5P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919751
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061369
Anemia	CTD Gene-Disease Associations	1.0	1.13313
BRD-K61366105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3813
GSE147435_1_v_0_kdm5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K28465224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01723
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344625
dorsal motor nucleus of the vagus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.994272
TRIM28	ENCODE Transcription Factor Targets	1.0	null
BRD-K71716722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27748
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
r10 part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47204
BRD-K56916066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91767
A388	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216953
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ltk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3673	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07701
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03527
RAD21	ENCODE Transcription Factor Targets	1.0	null
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
UNC13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28875
b-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.420004
RUVBL2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07525144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41605
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3117-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
RPL4	Pathway Commons Protein-Protein Interactions	1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phlpp1	GeneRIF Biological Term Annotations	1.0	null
Perturb_5792_KO_Gzma_SRP284215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.63562
USP1-UAF1 complex	CORUM Protein Complexes	1.0	null
BRD-K92891227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4725
GSE157609,GSE158123_0_v_1_ifi16_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67715154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61974
BRD-K28916436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84192
spleen	HPA Tissue Protein Expression Profiles	-1.0	-2.00846
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5107
FADU	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.94795
Brain Lower Grade Glioma_LGG_TCGA-DU-6401-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83297764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27551
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273967
hsa-miR-4265	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Rhinovirus infection_Nose_GSE11348	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.13487
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.5
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ZNF649	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77061
SAGA-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.433
TXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537223
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.753
BRD-K98723391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66879
UCHL5	Pathway Commons Protein-Protein Interactions	1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3719
KMH2	CCLE Cell Line Gene Expression Profiles	1.0	2.54037
Replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.763
GLO1	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17637
F7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K39224209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10879
NCIH2087	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65565
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8172-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5461-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.980063
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7469
FAM91A1	Pathway Commons Protein-Protein Interactions	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3182	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15417
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC4219345-1471-2121-14-52-S3.xlsx-BORIS_hNP1-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
Intracellular trafficking and peroxisomes	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16598
positive regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2023	1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
USP39	Pathway Commons Protein-Protein Interactions	1.0	null
regulators	GeneRIF Biological Term Annotations	1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.14234
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863874
GTEX-S33H-1126-SM-2XCB6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21943
FOXP1	ChEA Transcription Factor Targets	1.0	null
ERBB2_overexpression_230_GSE14990	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.40187
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13708
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68117
reduced female fertility	MPO Gene-Phenotype Associations	1.0	null
FLG	Pathway Commons Protein-Protein Interactions	1.0	null
DOK1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TF	Pathway Commons Protein-Protein Interactions	1.0	null
Flocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40425
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.88755
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09611
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31201
hsa-miR-4653-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Griscelli syndrome type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-448	TargetScan Predicted Conserved microRNA Targets	1.0	0.212286
ZNF768	Pathway Commons Protein-Protein Interactions	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30714
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842215
BMAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06988
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32485819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47563
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895627
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.89
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1-21170310-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.97052
abnormal skin physiology	MPO Gene-Phenotype Associations	1.0	null
SARS-CoV_96Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.73582
Anterior olfactory nucleus, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20171
rectum	HPA Tissue Protein Expression Profiles	1.0	1.48737
Lung adenocarcinoma_LUAD_TCGA-55-7725-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral hypothalamic area, mammillary region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.888184
guanethidine-1554	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K95729740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19063
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.980889
BRD-K62659610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26329
BRD-K44193634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65191
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SYK_druginhibition_154_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.77122
EGR1	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3125	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
Antropyloric mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.916
15656903-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562519
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DNA replication preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.552
GNL3L	Pathway Commons Protein-Protein Interactions	1.0	null
BCL6-25482012-CML-JURL-MK1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16275
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.964952
PMC8987207-DataSheet_1.xls-HEB_targets_Fig_2B-HEB_Activation_FC_1_5_ttest_0_05_shRNA_HEB_in_Jurkat_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
DNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53707
multisubunit	GeneRIF Biological Term Annotations	1.0	null
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal internal male genitalia morphology	MPO Gene-Phenotype Associations	1.0	null
heart	GTEx Tissue Gene Expression Profiles	-1.0	-0.93154
primary auditory cortex (core)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.837961
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057754
BRD-K24170552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29327
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36338
Perturb_14522_KO_Cnot3_ERP119587	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38115
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PFN1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7095
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HS-683 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
Social communication problems	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.804576
BRD-K81370109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06151
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263679
Inflammation	CTD Gene-Disease Associations	1.0	1.10977
mantle zone of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07012
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-RT4-FOXA1_peaks_Context1_2-Gene_Name_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926009
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14718
Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62055
A549_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167904
BRD-K72194126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31414
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.989962
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
Pleural mesothelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
NB17	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932671
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856896
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07898
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
BCAS2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963241
HNF4G	ENCODE Transcription Factor Targets	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
MIF	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980239
BRD-K84199148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14368
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09227140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91116
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00722
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96382853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37908
Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03267
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.865
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
BMI-1_DEPLETION_GDS2445_115_human_embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.868607
bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.782725
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.869424
BRD-K41548770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21647
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.95846
EP300_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6307
BRD-K00509183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02938
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72263
K562_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139854
nucleic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
L428	CCLE Cell Line Gene Expression Profiles	1.0	2.23935
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Anterior olfactory nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08053
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
Proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.475
PSME3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K22870904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06364
BRD-K22308901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07472
chlorpropamide-144	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.16527
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Cardiomyopathy, Dilated_Myocardial tissue_GSE3586	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.78894
YY1	ChEA Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92299
ethanol_homo sapiens_gpl96_gds2767	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q734-0526-SM-2I3EH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08517
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
pituitary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.4845
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKA3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26992
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81852
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.768
REST	ENCODE Transcription Factor Targets	1.0	null
BRD-K81510336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9647
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352776
key	GeneRIF Biological Term Annotations	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALDH9A1	Pathway Commons Protein-Protein Interactions	1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21771537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19504
BRD-K91241684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02149
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
RXRA	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-493	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.134
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87825
GSE148695,GSE167284_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65468
hsa-miR-4287	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58724
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47958
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.858938
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6514-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891828
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K58644442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.0834
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-4112-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALDOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38505
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09601
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SJ-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR1I2-20693526-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16484
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30437
ERP44	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K69594935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10248
BRD-K72467884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59291
Ub-specific processing proteases	Reactome Pathways 2024	1.0	null
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.326
Rectum adenocarcinoma_READ_TCGA-AF-6672-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91962463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37627
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46277
dipyridamole-2017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.13935
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 6 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12956
XPO5	Pathway Commons Protein-Protein Interactions	1.0	null
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87176
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.149322
GTEX-UJHI-0008-SM-4IHL1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847448
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62229896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14781
BRD-K62370517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08604
paclitaxel-640	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SRM	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K39107553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67089
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.01285
carcinine-3242	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2BK15ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormal fertility/fecundity	MPO Gene-Phenotype Associations	1.0	null
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
enzyme	GeneRIF Biological Term Annotations	1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51812
K562_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160022
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.885677
lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MET_knockout_248_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.49635
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
skin development	GO Biological Process Annotations 2015	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CCBL2	Pathway Commons Protein-Protein Interactions	1.0	null
Site of double-strand break	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.541
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HT-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228449
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14293
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.51094
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00771
Seckel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
BRD-K66762690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00688
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PRSS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58174
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K74317118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33631
SKNFI	CCLE Cell Line Gene Expression Profiles	1.0	1.44199
abnormal sex determination	MPO Gene-Phenotype Associations	1.0	null
BRD-K05970499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67183
PMC11185845-NIHMS1996282-supplement-Table_S1.xls-TableS1_txt-Kasumi_miR130_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_11041_KO_Tmem106b_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.4107
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57826
BL6780 (NIPBL)	NURSA Protein Complexes	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MM-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15669_KD_Hnrnpf_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.0267
abnormal gland morphology	MPO Gene-Phenotype Associations	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
DMS53	CCLE Cell Line Gene CNV Profiles	-1.0	-2.18332
BRD-K71139459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09813
BRD-K23670243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89334
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r3 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20695
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278276
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08639
Transcription export complex 2	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.56
BRD-K04559718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25209
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29529
Childhood Malignant Peripheral Nerve Sheath Tumor	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-3713	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.8156
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080927
Delta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.688
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K18402224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08252
DAP3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979796
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EF-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QLQ7-0726-SM-2I5G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19598
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LY-294002-424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_13592_OE_Mir322/Mir503_SRP348669	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.5522
RPS19BP1	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPI1	ChEA Transcription Factor Targets	1.0	null
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46921
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32227
hsa-miR-3150a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
BRD-K89701103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62003
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16867
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-6846-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55034
p80	GeneRIF Biological Term Annotations	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.394
BRD-K87399364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75298
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051146
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K01360791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53516
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anatomical structure development	GO Biological Process Annotations 2015	1.0	null
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
2966_FANCI_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51747
BRD-K73952959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09185
CENPJ	Pathway Commons Protein-Protein Interactions	1.0	null
K562_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213577
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
r2 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12687
Fanconi anemia complementation group I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.972
BRD-K20368781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63875
NOL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29997
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P1-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ABCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61281
Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50291
r4 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12277
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2598
hsa-miR-99b-5p	MiRTarBase microRNA Targets	1.0	null
arachidonic acid-604	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S7SF-0226-SM-3K2BI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00882
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17157
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
BRD-K35324337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04495
BRD-K37865854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00149
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QV-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1-21170310-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34445094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84615
DIS3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11264
HNF4A	ChEA Transcription Factor Targets	1.0	null
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43265
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
double-strand break repair	GO Biological Process Annotations 2023	1.0	null
BRD-K26024910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11477
GTEX-QXCU-0326-SM-2TC63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984897
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.17783
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20516
BRD-K61441533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23993
K562_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136886
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SSB	Pathway Commons Protein-Protein Interactions	1.0	null
XPO1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K06147970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15426
GSE168401_2_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3665	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GF1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZFAND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14721
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17289
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PMC3669416-pone.0064838.s001.xls-mHTT-HOXB1_HOXB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73183447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14743
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08613
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.43075
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME-180	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94129
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Orbital area, medial part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44373
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70931
MDAMB157	CCLE Cell Line Gene CNV Profiles	1.0	1.38384
VLDLR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29826
BRD-K59922784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05713
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8174725-ppat.1009603.s006.xlsx-neg_nsp3-ZSGvs_Untr-nsp3-ZSG_PATZ1	Rummagene Transcription Factor Associations 2026	1.0	null
CLASP1	Pathway Commons Protein-Protein Interactions	1.0	null
LRRC47	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K65182930_NVP-AUY922_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3361
COLO680N	CCLE Cell Line Gene CNV Profiles	-1.0	-3.15693
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COA5	Pathway Commons Protein-Protein Interactions	1.0	null
RELA_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8446
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
layer 4 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04426
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62605
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46153
PPIA	Pathway Commons Protein-Protein Interactions	1.0	null
FSP27_KO_GDS3768_514_mouse_White adipose tissue  (WAT)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K15202679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44169
Perturb_16092_KD_RRM2_SRP398748	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.23758
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.888665
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76746
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100452_HIP_possible Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18863
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27496
CASK	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.621428
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5351_KO_Dux_SRP201141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.72954
Disease	Reactome Pathways 2024	1.0	null
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
BRD-K09376136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52103
SUPT6H	Pathway Commons Protein-Protein Interactions	1.0	null
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12325
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.858211
stratum spinosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.637594
BRD-K09395335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.739
CORO1C	Pathway Commons Protein-Protein Interactions	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Secondary motor area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89288
KRT77	Pathway Commons Protein-Protein Interactions	1.0	null
Prelimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56912
FLI1	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC4580636-pone.0138782.s005.xls-Sheet1-Table_S3_List_of_Genes_with_RUNX1_binding_sites_in_each_Cytogenetic_Group_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.77626
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.559
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87485
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2319
KM-H2	GDSC Cell Line Gene Expression Profiles	1.0	2.47086
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Slx1-Slx4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.14
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06392309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29598
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-193b	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79334072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54314
Brain Lower Grade Glioma_LGG_TCGA-DU-5853-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220915
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.5559
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067106
Aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.783
RBFOX2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916389
SOX5	JASPAR Predicted Transcription Factor Targets	1.0	null
BRCA1-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.567
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.62783
cellular response to stimulus	GO Biological Process Annotations 2015	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3056
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59566
GSE155800_1_v_0_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
SNX3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92494
BRD-K28982281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18149
BRD-K66494817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01322
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7337-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
DPY30	Pathway Commons Protein-Protein Interactions	1.0	null
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.838747
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.07048
RTRAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13665
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14728
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6846_PSMA6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2968
testicular atrophy	MPO Gene-Phenotype Associations	1.0	null
usp12	GeneRIF Biological Term Annotations	1.0	null
CAL-120	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.39873
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76396
NANOG	ENCODE Transcription Factor Targets	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4739	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
TRMT11	Pathway Commons Protein-Protein Interactions	1.0	null
COV504	CCLE Cell Line Gene Expression Profiles	-1.0	-2.12984
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
SCC-15	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.47259
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.59718
TUBB2A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835728
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.74317
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50239
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GU-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.362646
PBMC cell line	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.14394
SMN-Sm protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.689
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10248509-Data_Sheet_5.CSV--GSE58294_DE-genes_AND_GSE66724_DE-Genes_AND_GSE41177_DE-Genes_NOT_Autophagy_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1341	COSMIC Cell Line Gene Mutation Profiles	1.0	null
18398820-table1	GeneSigDB Published Gene Signatures	1.0	null
AHCYL2	Pathway Commons Protein-Protein Interactions	1.0	null
Ctf18 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.431
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58379
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0173
HDLM2	CCLE Cell Line Gene Expression Profiles	1.0	2.71067
C1orf35	Pathway Commons Protein-Protein Interactions	1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.813569
KDM6A-18722178-U937_AND_SAOS2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27496
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USP12	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3702
BRD-K13275816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02929
PMC9823215-mmc4.xlsx-Sheet1-List_of_genes_commonly_upregulated_by_wild_type_and_zinc_finger_mutant_of_LIN28A_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
DMS454	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58271
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8811
BRD-K37254228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53321
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
VIIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.873165
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23118
prenatal growth retardation	MPO Gene-Phenotype Associations	1.0	null
GSE88819_1_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144656
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3746
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5465-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPK-0226-SM-3MJH6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896451
PMC11666716-41698_2024_782_MOESM1_ESM.pdf-2-PRDM10_PRDM10	Rummagene Transcription Factor Associations 2026	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
GTEX-SE5C-0726-SM-4BRWY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870438
lateral group of nuclei, right, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.850027
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chr3_39006621_G_A_b38	GTEx eQTL 2025	1.0	1.29181
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K58963469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02391
BRCA1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.575669
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40933
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
BRD-K68160857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3096
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-M39894156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28103
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	HPA Tissue Protein Expression Profiles	1.0	1.48737
EEF1D	Pathway Commons Protein-Protein Interactions	1.0	null
PPARD	ChEA Transcription Factor Targets	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.544
NSMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31051
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52595
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.985845
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	1.0	0.881773
DNA binding	GO Molecular Function Annotations 2023	1.0	null
ZMAT5	Pathway Commons Protein-Protein Interactions	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.838747
nuclear	GeneRIF Biological Term Annotations	1.0	null
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
translocates	GeneRIF Biological Term Annotations	1.0	null
GTEX-OHPM-0726-SM-3LK7A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862572
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43062
TXN	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.845528
Lung squamous cell carcinoma_LUSC_TCGA-43-6771-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
ACADM_KO_GDS4546_512_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PRDX1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
reproductive system phenotype	MPO Gene-Phenotype Associations	1.0	null
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SARS-BatSRBD_36Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.99891
MBD4	ENCODE Transcription Factor Targets	1.0	null
BRD-K25444802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03301
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.07329
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Calu-6	GDSC Cell Line Gene Expression Profiles	1.0	1.89777
DHX8	Pathway Commons Protein-Protein Interactions	1.0	null
eGFP-HDAC8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
nerve cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.95384
A673	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77659
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0009
periventricular stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1202
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47262
osteosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.876129
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56415
vacuole	GO Cellular Component Annotations 2015	1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7142-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232385
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF-00875133-00-5928	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
protein deubiquitination	GO Biological Process Annotations 2015	1.0	null
BRD-K50008138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21616
Arsenic	CTD Gene-Chemical Interactions	1.0	null
GSE151782_2_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Middle silk gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
YIPF1	Pathway Commons Protein-Protein Interactions	1.0	null
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K81925504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39332
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06783
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22605
hsa-miR-4283	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
Acid phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.651
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autolysosome lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.486
Nuclear replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.772
cervical carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.608527
BRD-K30761927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47304
HH	CCLE Cell Line Gene Expression Profiles	1.0	2.10767
BRD-K55479099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06906
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40803
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6005
NCIH209	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74762
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227858
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
PMC11109217-41420_2024_2017_MOESM3_ESM.xlsx-Fig_4H_TAF2-bound_genes-Tag_dentsity_of_TBP_ChIP-seq_signal_for_TAF2-bound_genes_in_Fig_4H_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
kidney	HPA Tissue Protein Expression Profiles	-1.0	-1.01653
BRD-K99413603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75622
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16122
periventricular stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47262
MJ	CCLE Cell Line Gene Expression Profiles	1.0	1.50885
CAPAN1	CCLE Cell Line Gene CNV Profiles	1.0	2.11561
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0286
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36373
BRD-K28596345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28343
SP4	ENCODE Transcription Factor Targets	1.0	null