association	dataset	threshold value	standardized value
TRAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81448
common	GeneRIF Biological Term Annotations	1.0	null
HC 030031	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
osteoclastogenesis	GeneRIF Biological Term Annotations	1.0	null
regulation of JNK cascade	GO Biological Process Annotations 2023	1.0	null
GATA3-21867929-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TFEB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49438
PMC8755441-mmc3.xlsx-IRF7-Up-Symbol_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3931013__F3	PFOCR Pathway Figure Associations 2023	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849532
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PECAPJ34CLONEC12	CCLE Cell Line Gene CNV Profiles	1.0	1.94893
ALG10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82563
GTEX-T2IS-1926-SM-4DM74	GTEx Tissue Sample Gene Expression Profiles	1.0	2.58784
Hip Fractures	HuGE Navigator Gene-Phenotype Associations	1.0	null
KU 55933	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
PMC8175556-42003_2021_2140_MOESM6_ESM.txt--BHLHE40_BHLHE40	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH3255	CCLE Cell Line Gene CNV Profiles	1.0	1.42371
GTEX-QMRM-1726-SM-2S1QG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CAMSAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61598
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.48833
mantle zone of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56942
Limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.208
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	141.474
SPEN	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.34051
CLPP_KO_GDS4791_374_mouse_Testies	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.216386
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.664
GTEX-WHPG-2626-SM-3NMBR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2887
BRD-K99036206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09902
BRD-K62841603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08663
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.056
Enzastaurin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.1
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
hsa-miR-27b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TATDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.065
GTEX-PWOO-2026-SM-48TDE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912762
BRD-K66287173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65313
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
U20S	BioGPS Cell Line Gene Expression Profiles	1.0	1.34341
Ovotestis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
SALL4	ChEA Transcription Factor Targets	1.0	null
connective tissue disease	GWASdb SNP-Disease Associations	1.0	0.476947
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3839
Gastric cancer	KEGG Pathways 2026	1.0	null
FBXL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88016
MRC-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.139
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K99074976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31961
RAD21	ENCODE Transcription Factor Targets	1.0	null
Perturb_7052_KO_Grk2/Grk5/Grk6_SRP090395	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.17255
SUZ12	ChEA Transcription Factor Targets	1.0	null
POU2AF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11033
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844792
AU565	CCLE Cell Line Gene CNV Profiles	1.0	1.84488
GTEX-QEG5-0626-SM-2S1PP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE157960_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE179693,GSE179694_4_v_2_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SFRP1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.201672
XAV 939	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4963
CAPZA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.75392
SPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2995
striatal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00767
Perturb_8947_Mut_RB1_SRP220467	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.34501
epithelial cell proliferation	GO Biological Process Annotations 2015	1.0	null
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4434
OCRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23864
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Autoimmune disease of skin and connective tissue	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
positive regulation of macromolecule metabolic process	GO Biological Process Annotations 2023	1.0	null
MEC2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.85232
Tetraamelia syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
likely	GeneRIF Biological Term Annotations	1.0	null
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2918
Hyperostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.01
Joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.108
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04675
GTEX-WOFL-0126-SM-3MJG2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861566
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
(S)-Selisistat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XV7Q-2526-SM-4BRV9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31076
H3-3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95405
tanespimycin-4450	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tropicamide-4280	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K93990956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09922
Secretory IgA immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.732
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8577
cingulate gyrus, frontal part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.856262
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34334
4-Nitropiazthiole	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.57
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.837
DDX3Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62084
valproic acid-4464	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1344
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
marker	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPK5-1626-SM-4JBHI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891918
musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
accumbens nucleus, shell domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38844
NCIH2228	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58806
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859684
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TTC31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19004
bone	GeneRIF Biological Term Annotations	1.0	null
BTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54781
periventricular stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13855
tremorine-5799	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OVOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42741
GTEX-OHPM-0126-SM-2YUN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0392
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42K-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04929
ZNF337	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98863
accrual	GeneRIF Biological Term Annotations	1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6524
Becker Muscular Dystrophy	DisGeNET Gene-Disease Associations	1.0	null
MRE11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95178
ZNF224	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62402
INKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84452
ADCY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70764
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.985398
BRD-K03654379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47164
PMC7888617__F2	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K42091424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90951
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	GO Biological Process Annotations 2025	1.0	null
sulpiride-1467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
eldeline-2171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30834
BICR16	DepMap CRISPR Gene Dependency	1.0	2.9564
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6928
mantle zone of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01345
cellular senescence	GO Biological Process Annotations 2015	1.0	null
PMC7086291__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.562
ZNF554	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92609
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
regulation of cell death	GO Biological Process Annotations 2023	1.0	null
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.348519
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02769
TACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42344
ACAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93467
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919925
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K69347147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20441
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
lymphnode_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.15505
NR0B1-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mineral	GeneRIF Biological Term Annotations	1.0	null
HS840T	CCLE Cell Line Gene Expression Profiles	1.0	1.42691
LY2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.26321
biological regulation	GO Biological Process Annotations 2015	1.0	null
DACT1	Pathway Commons Protein-Protein Interactions	1.0	null
RGL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78106
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K62504352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00707
hematological neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.147833
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.4442
chronic lymphocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.661594
GTEX-Q734-1926-SM-2I5EV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903605
Fractures, Bone	HuGE Navigator Gene-Phenotype Associations	1.0	null
ADAM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80357
GRK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36244
GTEX-TMZS-0126-SM-3DB9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59699
Sclerosteosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.196
SPATC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44618
BRD-K63093217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12362
DENND6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52152
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-PWN1-2526-SM-48TDS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69307
MINDY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99218
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54874
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
Mandibular condyle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.732
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Dorsal fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.644
HS737T	CCLE Cell Line Gene Expression Profiles	1.0	1.4543
synergistic	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-181a-5p	MiRTarBase microRNA Targets	1.0	null
GSE145249_0_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XQ3S-1526-SM-4BOOC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32815
Perturb_11612_KD_BRD8__SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.1565
KRT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.319
HA1E	DepMap CRISPR Gene Dependency	1.0	2.47232
BHLHA15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9008
FAAP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4165
GTEX-U3ZN-1626-SM-4DXTZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09476
SLC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55642
FLAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56376
generation of neurons	GO Biological Process Annotations 2025	1.0	null
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58085
GTEX-QCQG-1226-SM-48U23	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36071
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2252
determination	GeneRIF Biological Term Annotations	1.0	null
CEBPB	JASPAR Predicted Transcription Factor Targets	1.0	null
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02498
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7302
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12359218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09725
NFATC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99758
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
ZNF398	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13524
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0586
regulation of response to stress	GO Biological Process Annotations 2015	1.0	null
ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.416195
Craniofacial region	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.976
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UTP6	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-Symbol_1_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
Epithelial stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.86
PANX3	Pathway Commons Protein-Protein Interactions	1.0	null
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
wnt7b	GeneRIF Biological Term Annotations	1.0	null
MAMSTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75319
PHC1-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-P4PP-2526-SM-3P61P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966771
b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217554
Wnt	InterPro Predicted Protein Domain Annotations	1.0	null
HDMYZ	CCLE Cell Line Gene Expression Profiles	1.0	1.3922
GSE202434,GSE202438_10_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
parolfactory gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26789
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.262
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.11571
SYT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60114
Perichondrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.763
SKOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22509
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
SLC9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23935
DVL2	Pathway Commons Protein-Protein Interactions	1.0	null
GNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50999
Prestwick-1100-3880	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.944259
PF-01378883-00-6405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CC-401	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.8
PMC12146336-Data_Sheet_1.pdf-12-PAX5_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07667606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83414
hsa-miR-1207-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.9459
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
quinethazone-3875	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831138
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
hsa-miR-451b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
fenofibrate-7474	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K48143921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10379
uterine endometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.684327
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
fluocinonide-3933	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
estradiol_homo sapiens_gpl14550_gse35034	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8953253__F4	PFOCR Pathway Figure Associations 2024	1.0	null
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SMAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92081
esr1c6orf97	GeneRIF Biological Term Annotations	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.945942
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
TAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5902
ZNF787	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24547
Orbital area, lateral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56616
CDK19_knockdown_162_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.95808
GTEX-WFON-1926-SM-3LK7L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902584
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
SARM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88645
Adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
hsa-miR-4329	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2401
colon	HPA Tissue Protein Expression Profiles	1.0	1.55255
debrisoquin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15507
Lumbar spine bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	5.05229
Prostate adenocarcinoma_PRAD_TCGA-KK-A8ID-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.695
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.902281
Osteoclast stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.463
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K97576000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74967
DNTTIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18676
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
COG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01352
ESR1-20056654-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
intermediate stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90598
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.894023
ABCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61281
ncadherindependent	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4762-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.725
SMARCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65296
ALG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64845
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
vagina	GTEx Tissue Gene Expression Profiles	1.0	1.58859
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49141
Prostate adenocarcinoma_PRAD_TCGA-FC-A8O0-01A-41R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055918
BOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84631
Cortical thickness	GWAS Catalog SNP-Phenotype Associations	1.0	0.572839
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055266
TAL1	MotifMap Predicted Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RB1_KD_GSE50532_591_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
sulfasalazine-204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cefixime-4567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sulforaphane	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.95
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860696
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
Perturb_17609_OE_U2AF35_SRP116787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.58939
single-organism process	GO Biological Process Annotations 2015	1.0	null
tanespimycin-4449	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
r8 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19891
GNG7	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-297	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3096
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1546
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
Multimeric ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.903
Cortical thickness	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.969897
troglitazone-4456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
MLMA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Ischemic bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
later	GeneRIF Biological Term Annotations	1.0	null
CEBPD-21427703-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FHOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43509
PMC9391581-mmc5.xlsx-WT_KLF4_vs_GFP-gene_name_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
CAVIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84269
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Dental papilla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.648
GTEX-VJYA-0426-SM-3GIJK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
rostral ventrolateral reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69132
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
19192944-TableS4	GeneSigDB Published Gene Signatures	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Periodontitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
MRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20163
Marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.605
MSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17213
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
burkitt lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.393064
BRD-K49490091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8381
Car cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.633
tendon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.161962
SLC24A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41991
Bed nuclei of the stria terminalis, posterior division, interfascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09861
Celastrol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.3
TE6	DepMap CRISPR Gene Dependency	1.0	3.93798
GTEX-OXRP-0126-SM-3NB32	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93672
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.8535
H-10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.57
VCPKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30216
NQO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87222
BRD-K44722555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46969
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09197
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.203022
terminal nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0887
inhibition	GeneRIF Biological Term Annotations	1.0	null
BRD-K05125666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58097
GGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10859
keratinocyte proliferation	GO Biological Process Annotations 2015	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39417
r9 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41716
MKN45	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
VZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1103
BRD-K95334975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16959
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77060313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12671
Synoviocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.129
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040885
Ischemic Cardiomyopathy	DisGeNET Gene-Disease Associations	1.0	null
Anterior cingulate area, ventral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18339
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
Fetal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.893
SW1990	CCLE Cell Line Gene Expression Profiles	1.0	1.54941
optic cup formation involved in camera-type eye development	GO Biological Process Annotations 2015	1.0	null
JVM3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85015
OLA1	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16693
GTEX-XUW1-0426-SM-4BOOT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20039
BHT-101	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42951
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.0557
positive regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23762204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30674
SPARC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43192
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.164
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.397
9+0 non-motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.242
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
previously	GeneRIF Biological Term Annotations	1.0	null
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-O5YT-0226-SM-32PK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
susceptibility	GeneRIF Biological Term Annotations	1.0	null
lymphoma	GWASdb SNP-Phenotype Associations	1.0	0.481935
BRD-K15400067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41681
positive regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PCGF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90308
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24925
Hair shaft	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.186
697 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5854-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anchoring collagen complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.656
ChIP_RNF2_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE100102_4_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.39276
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.695
lower dorsal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00767
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.056
GTEX-NFK9-1326-SM-3LK5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-X4EP-0126-SM-3P5YV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02415
geldanamycin-4452	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE124375_10_v_9_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sublayer 6b of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08258
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t55-gastrocnemius_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	8.28962
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
Perireunensis nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07378
deferoxamine-3842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
10-methoxyharmalan-2893	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K46439376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.17527
periventricular stratum of r8Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20004
BRD-K07496812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47757
benzamil-2200	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rs7903146	GeneRIF Biological Term Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01411
femoral	GeneRIF Biological Term Annotations	1.0	null
positive regulation of gene expression	GO Biological Process Annotations 2025	1.0	null
GTEX-QDT8-0011-R8A-SM-32PKE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
HDAC9	Pathway Commons Protein-Protein Interactions	1.0	null
negative regulation of cell death	GO Biological Process Annotations 2023	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A64O-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70695911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45428
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2887
ZNF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49918
genetic	GeneRIF Biological Term Annotations	1.0	null
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2423
GTEX-TSE9-0726-SM-3DB8C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886461
BRD-K97977764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10676
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
cotinine-5611	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.427
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.465
PIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68974
18006806-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Articular cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.064
496100432_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.62358
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17611
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.964999
MERO14	DepMap CRISPR Gene Dependency	1.0	2.62949
U0125-663	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MKN45	CCLE Cell Line Gene Expression Profiles	1.0	1.74749
Lung squamous cell carcinoma_LUSC_TCGA-58-8390-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GAS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99003
myometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191497
Neural arch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
SUPT11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63015
BRD-K56987307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21369
BRD-K12281552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11448
GTEX-OIZI-0226-SM-2XCEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-QLQ7-1626-SM-2S1R8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3191
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.1129
aging	GO Biological Process Annotations 2015	1.0	null
GTEX-OHPK-2026-SM-3MJH7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83374
EB-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847697
SHD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22173
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.83495
thiamine-2894	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
salsolidin-2463	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51411441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20486
hsa-miR-4772-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
TM7SF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76846
TOLEDO	CCLE Cell Line Gene Expression Profiles	1.0	1.63989
ARC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74575
biological_process	GO Biological Process Annotations 2015	1.0	null
PMC11221067-JCMM-28-e18520-s002.xlsx-Supplementary_Table_2-BHLHE40_BHLHE40	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0126-SM-4AD6S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12199
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	2.21241
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58515
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
HLFA	CCLE Cell Line Gene Expression Profiles	1.0	2.25278
ECE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66715
WDR74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51042
myometrial	GeneRIF Biological Term Annotations	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
PTEN_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
BBS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72138
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02769
FOXH1-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CYP20A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.96382
ventrolateral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62857
RNF2-27304074-CHIP-SEQ-NSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC7494657__F4	PFOCR Pathway Figure Associations 2024	1.0	null
496100607_TCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19625
cefaclor-2483	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.564035
Anterior olfactory nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.50931
MKN45	DepMap CRISPR Gene Dependency	1.0	9.44954
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19464
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.298163
Brain_CT2_MGE 258	HuBMAP ASCT+B Annotations	1.0	null
BRD-K02230174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38333
Pluteus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.949
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
AZD 6482	DeepCoverMOA Drug Mechanisms of Action	1.0	0.89
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.8091
Lung adenocarcinoma_LUAD_TCGA-50-5051-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7288
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
CHEMBL2172374	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
skin development	GO Biological Process Annotations 2023	1.0	null
SNU1033	CCLE Cell Line Gene Expression Profiles	1.0	1.71999
cellular response to oxidative stress	GO Biological Process Annotations 2025	1.0	null
r8 part of linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21414
ENOSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64729
BRD-K39624517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00889
lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09763
OCUM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Annulus fibrosus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
GTEX-Q2AH-1626-SM-3GAF8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928315
BRD-K04371719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72115
hsa-miR-103a	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
ZIC5_01_284	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60411
PMC9391581-mmc5.xlsx-KLF4_K409Q_vs_WT_KLF4-gene_name_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38431962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76009
GSE226452_1_v_2_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5495
BRD-K42671261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17039
dorsomedial preoptic area, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02692
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860582
PRKCA_KO_GDS2141_300_mouse_small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.03926
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.01368
KIF18B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11651
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05244
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Supplementary_Table_2C_Contrast_ATF4-def_DMSO_8h_vs_HCT116_DMSO_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05211
regulation of mapk cascade	GO Biological Process Annotations 2015	1.0	null
BRD-K91137832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67241
subbrachial nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.58506
ZNF865	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99835
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060364
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835215
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12766
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26577
GTEX-PLZ4-2726-SM-3P61A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24334
RNF2-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC3775648__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29804
Tooth agenesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
BRD-K12925598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58734
Perturb_9833_KD_TBX3_SRP122892	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.53357
negative regulation of apoptotic signaling pathway	GO Biological Process Annotations 2025	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.824116
MM1S	DepMap CRISPR Gene Dependency	1.0	2.55923
LIVF001-012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97297
TEAD4	ChEA Transcription Factor Targets	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
nalidixic acid-3668	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28619632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27729
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61097
iopromide-4504	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RNF2	ChEA Transcription Factor Targets	1.0	null
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
chlorpromazine-4441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SSA3-0426-SM-32QPI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BORCS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25803
UBA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3408
SMO	Pathway Commons Protein-Protein Interactions	1.0	null
frizzled binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K63829331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81044
BRD-K33956641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59324
NCI-H441	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
hsa-miR-27a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
KYO1	DepMap CRISPR Gene Dependency	1.0	4.63668
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847697
BRD-K13090434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13552
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.458
GOLGA6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38285
DNAJB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62685
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.765711
PGD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98568
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19447
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
resistance	GeneRIF Biological Term Annotations	1.0	null
dorsal periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35858
BRD-K74896637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57693
sublayer 6a of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40817
Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bone structure disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
ARHGAP35	Pathway Commons Protein-Protein Interactions	1.0	null
layer 3 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83266
abnormal compact bone thickness	MPO Gene-Phenotype Associations	1.0	null
targetede2apbx1	GeneRIF Biological Term Annotations	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-UJHI-1526-SM-3DB99	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03179
ZNF786	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48806
Prestwick-664-3715	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K84388444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03042
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.81447
bone remodeling disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
density	GeneRIF Biological Term Annotations	1.0	null
Bone remodeling disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.597
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.12286
GTEX-VJYA-1126-SM-3GIJU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85405
Fertilization envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.659
mantle zone of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41596
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.788
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64699
KNSTRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87021
NCI-H2347	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.56811
BRD-K65488906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08127
ID3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91639
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
NEFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11093
Acitretin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues	GeneRIF Biological Term Annotations	1.0	null
SOX4	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-PWO3-1526-SM-48TCM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.43437
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12492021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14662
GPCR ligand binding	Reactome Pathways 2024	1.0	null
GTEX-WFG8-2226-SM-3GIL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19399
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ABHD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90799
sirolimus-5927	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HUNS1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64004
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABCA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95994
BRD-K34117117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47525
18410693-TableS4	GeneSigDB Published Gene Signatures	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.63832
PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
ABCC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74625
low-density lipoprotein receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.112
NSUN5P2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68219
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56888
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Wnt signaling pathway	GO Biological Process Annotations 2023	1.0	null
lymphnode_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.857326
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHISA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19031
UNC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39924
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.637
TYK2_knockdown_35_GDS4754	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.56006
BRD-K39411863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99106
proteinaceous extracellular matrix	GO Cellular Component Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AE-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67357
ZNF581	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80177
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_17_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
ARID1B_01_298	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.99737
TRIP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06019
BRD-K36064145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54363
Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_15_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
TLCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95651
Lateral septal nucleus, rostral (rostroventral) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01345
mRNA_AES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GADD45G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57051
unreported	GeneRIF Biological Term Annotations	1.0	null
Intervertebral disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.038
BRD-K64567246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82799
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59273
BRD-K05135707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21089
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.1556
BRD-K28510065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32872
SF539	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.6181
BRD-K27287379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16669
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2074
KDM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19603
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02769
MARVELD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19434
GTEX-XQ8I-0426-SM-4BOPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00042
hematologic cancer	GWASdb SNP-Disease Associations	1.0	0.176194
proxymetacaine-5433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85866
bone remodeling disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.839705
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sulfanilamide-2709	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
procainamide-2618	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-VUSG-2326-SM-4KL1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20028
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alpha-estradiol-6169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K68995447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57487
SLC7A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33131
laterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0738
BRD-K23204256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00054
GTEX-PVOW-0126-SM-2XCFA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78135
superficial stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69209
ASL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38046
CREBBP	ENCODE Transcription Factor Targets	1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.45476
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-WH7G-0926-SM-4LVMJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.64668
(+/-)-catechin-3351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U3ZN-0926-SM-4DXTU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15592
Ulipristal	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
ciprofibrate-6138	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7828172__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC6870463-Table_7.xlsx-Family_H_LPS-LPS_treatment_of_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
body of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26538
BRD-K26273412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59799
positive regulation of jnk cascade	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bone mineral density (paediatric, upper limb)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.7
tinidazole-3896	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCT8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52168
septopallidal shell area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.45735
wnt signaling pathway	GO Biological Process Annotations 2015	1.0	null
PMC11601945-jci-134-173770-s148.pdf-6-ENSG00000137309_HMGA1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
cranium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.351856
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00914921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25134
Mesenchyme	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.069
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82992
lateral septal nucleus, intermedio-dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04081
decreased compact bone thickness	MGI Mouse Phenotype Associations 2023	1.0	null
FMK	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
BRD-K75380271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98615
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60567
keratinocyte differentiation	GO Biological Process Annotations 2015	1.0	null
BRD-K83902026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16857
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
PMC9942993-pone.0281645.s002.xlsx-non-AR_as_all_as_gained-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90579
BRD-K42084582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33242
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PRKAG3_KO_GDS1398_703_mouse_gastrocnemicus muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PHF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96225
647-V	GDSC Cell Line Gene Expression Profiles	-1.0	-1.62326
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26632
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Scoliosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
stratum pyramidale of rostral CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23059
Bone mineral density	GWAS Catalog SNP-Phenotype Associations	1.0	1.55662
CLPP_KO_GSE40207_378_mouse_Testies	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Wnt signaling pathway	KEGG Pathways 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VH-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tetrahydroalstonine-2748	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69479
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
KRTCAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36368
3-acetylcoumarin-5624	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bone marrow stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.563
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.28887
BRD-K86722849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45028
GTEX-XXEK-2226-SM-4BRUM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00563
PMC10916124-12864_2024_10174_MOESM1_ESM.xlsx-Supplementary_Table_6-The_downstream_genes_targeted_by_FLI1_The_ligand_vs_receptor_pairs_genes_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Syndactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Sebaceous gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.979
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-TPRX1_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_TPRX1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-548a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Aorta endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
PMC5503541-oncotarget-08-38399-s003.docx-1-TCF7L1_TCF7L1	Rummagene Transcription Factor Associations 2026	1.0	null
atractyloside-3695	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAP3K9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62736
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.202636
Roflumilast	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.40904
ChIP_SUZ12_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
cellular component organization	GO Biological Process Annotations 2015	1.0	null
GSE210093_0_v_2_taf15_human	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.79985
therapy	GeneRIF Biological Term Annotations	1.0	null
KARPAS422	DepMap CRISPR Gene Dependency	1.0	4.61135
PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
epithelial cell differentiation	GO Biological Process Annotations 2015	1.0	null
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Archenteron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.441
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.93213
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8708
BRD-K61020385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4428
kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.103585
GSE180631_1_v_0_yap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K31348453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01108
UBXN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58143
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23729
KIF20A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53773
XPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39745
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88045
PMC9391581-mmc4.xlsx-WT_KLF4_vs_GFP-activated-gene_name_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
ACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37575
tiaprofenic acid-4171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-374a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K63579322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71154
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
FES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86586
GNG2	Pathway Commons Protein-Protein Interactions	1.0	null
ANKRD34B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36296
wnt signaling pathway	KEGG Pathways	1.0	null
morula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071443
mesenchyme	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.600077
VTI1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94082
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.63275
Long bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.022
Signaling by GPCR	Reactome Pathways 2024	1.0	null
Synovial tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.671
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.7928
GTEX-S341-0726-SM-4AD5R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Carcinoma Of Bladder	DisGeNET Gene-Disease Associations	1.0	null
APOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24906
ABITRAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36638
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82915
SLC41A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57976
CCDC69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99977
ALS2CL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71627
caudal group of intralaminar nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00787
acacetin-6044	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K29842194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82364
Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MB-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28512751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19717
BRD-K14534138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99322
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091879
CACNG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50749
BRD-K00590556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37896
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.29306
COX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64307
GTEX-OHPL-2526-SM-3MJGT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8477
uterine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02075
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833553
PMC8687553-pone.0261191.s009.xlsx-KLF4-related-Unnamed_0_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RAB3A_Mutation - D77G point mutation_GDS2482_702_mouse_Cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
trochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04187
BRD-K95937143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93418
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27911
GTEX-SIU8-0226-SM-2XCDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K33194123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27129
GTEX-V955-2026-SM-3GAFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
blastomere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070235
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8988201-EMMM-14-e14990-s008.xlsx-Sheet1-Dataset_EV6_Wnt_and_Hh_pathway_associated_genes_assessed_for_differential_expression_after_GPR56_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PHA-00745360-3910	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hair follicle outer root sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.426
TNP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48036
involving	GeneRIF Biological Term Annotations	1.0	null
BRD-K02946901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49112
SAE1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JA-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16727544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15266
Hair follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.604
Bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.651
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.256925
FIPI HCl	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
Epithelial to mesenchymal transition in colorectal cancer	WikiPathways Pathways 2024	1.0	null
orphenadrine-4537	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-Hallmark_pathways-BHLHE40_BHLHE40	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate isthmic part of the dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03606
GTEX-NPJ8-0126-SM-2YUNR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973742
TB-LM or TBLH-BMD (pleiotropy)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.95229
ST8SIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43885
phenylpropanolamine-3217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
chronic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.656441
TRAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69222
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE196699_7_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
camptodactyly-arthropathy-coxa vara-pericarditis syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
GTEX-N7MS-0926-SM-2HMIZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870809
regulation of jnk cascade	GO Biological Process Annotations 2015	1.0	null
BRD-K51757923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02271
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bone remodeling disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.222
NT5C3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95497
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15134
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dentinogenesis imperfecta	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
BRD-K78828094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2587
BRD-K18346873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35138
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
MAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79795
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.82707
regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.526
BRD-K07981644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01082
NIFK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12525
GTEX-TMMY-0126-SM-4DXTP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Tail bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.907
mbl2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
GSE213632_0_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chlorogenic acid-4142	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81289
SMC3	ENCODE Transcription Factor Targets	1.0	null
GSE235682_1_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARHGDIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99349
ChIP_TBX3_20139965	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-QDT8-2526-SM-48TYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17235
propylthiouracil-2476	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STL321288	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
PARP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60573
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CDK19_knockdown_164_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.32246
Tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
dishevelled2	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-633	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Spinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
B4GALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83391
GTEX-UJHI-0226-SM-4IHJL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.02671
ovary	HPA Tissue Gene Expression Profiles	-1.0	-1.17326
Dermal papilla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.445
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.031
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
LCN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07215
UBE2V2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34589
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19947
GTEX-XQ8I-0926-SM-4BOOF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55471
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056691
ZNF684	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20179
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.903049
BRD-K49656278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09482
periventricular stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07724
estradiol-4432	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1505
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18763924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73322
Lumbar spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.171
697 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.08811
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
ARFIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94123
NCIH69	CCLE Cell Line Gene Expression Profiles	1.0	1.58574
ZNF638	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55007
IDH3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12572
HSF4	Pathway Commons Protein-Protein Interactions	1.0	null
H2AC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00805
GTEX-SJXC-0008-SM-4DM7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85698
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986266
BRD-K61877191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36387
NF-Y	MotifMap Predicted Transcription Factor Targets	1.0	null
SLC25A46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.79928
BRD-K47999752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26317
YIPF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82207
Blastoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.042
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26775
BRD-K64939364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28125
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.398
GSE248874_1_v_0_pcdh9_human	RummaGEO Gene Perturbation Signatures	1.0	null
exocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092134
GTEX-T6MN-0426-SM-32PMF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K97935314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45195
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.76454
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.90768
BRD-K08899466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06943
u2197	HPA Cell Line Gene Expression Profiles	1.0	0.889306
septopallidal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03282
BRD-K96075847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08366
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06395
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.482844
GTEX-XUZC-0626-SM-4BOPG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
SNU182	DepMap CRISPR Gene Dependency	1.0	2.27283
CRCGN011_HEPG2_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6666
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66993
Cartilage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
skeleton phenotype	MPO Gene-Phenotype Associations	1.0	null
BRD-K72213294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05098
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K11016405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45347
L-Wnt-3A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
MARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95759
hair follicle bulge	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.70886
NTPCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12607
TBX3	ChEA Transcription Factor Targets	1.0	null
GTEX-N7MS-0225-SM-4E3HO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9009
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
VMA21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84069
hsa-miR-4763-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
PMC7677084__F9	PFOCR Pathway Figure Associations 2024	1.0	null
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.859541
paraventricular nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4913
496100451_TCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50501
constitutively	GeneRIF Biological Term Annotations	1.0	null
proglumide-3861	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K87191742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84288
Ibrutinib2	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
epidermal cell differentiation	GO Biological Process Annotations 2025	1.0	null
BRD-K45315294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51733
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98412
insulin-like growth factor binding protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
MFHAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46759
Preosteoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.899
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1494
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82246
Germ cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867046
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormal compact bone area	MPO Gene-Phenotype Associations	1.0	null
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24486
ETS1	ENCODE Transcription Factor Targets	1.0	null
QRSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16842
KPNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94249
bmd	GeneRIF Biological Term Annotations	1.0	null
periventricular stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.50778
Perturb_11916_KO_Kdm6a_SRP166658	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.65755
Arthropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXM1-26100407-CHIP-SEQ-HEK293-FLP-IN-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.980839
Arsenic	CTD Gene-Chemical Interactions	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RT-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39936
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040763
Paget's disease of bone	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
FZD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77944
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872142
bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.401945
external female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.160583
Enamel knot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
Gastrula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.463
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
ascorbic acid-6306	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6987486__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GNE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67782
BRD-K09842906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.08242
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
fulvestrant-4462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9929
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7687
bisoprolol-2642	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWO3-0011-R2A-SM-2S1OX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CFAP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3485
positive regulation of JNK cascade	GO Biological Process Annotations 2023	1.0	null
AP3M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44075
POU3F2	ChEA Transcription Factor Targets	1.0	null
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2327
napelline-6824	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
myometrial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.428783
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
LOX-1_OE_GDS4262_435_human_HAECT - aortic endothelial cell line - 24 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.907064
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.13484
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
MTRF1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47325
BRD-K24727463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05551
CLCN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44025
wnt11	GeneRIF Biological Term Annotations	1.0	null
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-EF-5830-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XK95-0226-SM-4AT58	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966613
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873882
LSM1	Pathway Commons Protein-Protein Interactions	1.0	null
AFF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34457
ESR1-30970003-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN011_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45085
GTEX-QLQW-1126-SM-2S1Q8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04512
Brain Lower Grade Glioma_LGG_TCGA-QH-A6XC-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
Epiphysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.507
Nephritis	CTD Gene-Disease Associations	1.0	1.14747
GTEX-XAJ8-0826-SM-47JY6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10259
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
CRCGN014_HEPG2_3H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05839
extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
BRD-K40117723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9491
GSE57397,GSE57399_1_v_0_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
vigabatrin-2452	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
treatment	GeneRIF Biological Term Annotations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2840-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular response to stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K98169006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38712
G protein-coupled receptor binding	GO Molecular Function Annotations 2025	1.0	null
MSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8096
positive regulation of signaling	GO Biological Process Annotations 2015	1.0	null
MYF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94761
osteoporosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.909787
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
Wnt Signaling Pathway(Mus musculus)	WikiPathways Pathways 2014	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34205
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
hsa-miR-3151	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
conceptus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212586
BRD-K35788497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50702
CDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32232
GTEX-SUCS-1926-SM-32PM3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1095
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3645
Hyperparathyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
RG2833	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.9
BRD-K76966915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95696
HLA-B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5514
ovary_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
colonrectum_f	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ergocalciferol-2442	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.07093
eb1	GeneRIF Biological Term Annotations	1.0	null
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DAOY	CCLE Cell Line Gene CNV Profiles	1.0	1.58172
BRD-K61274359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01471
dementia	GWASdb SNP-Disease Associations	1.0	0.965088
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.64461
GTEX-SN8G-0126-SM-32PLI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875867
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2984
tissue remodeling	GO Biological Process Annotations 2015	1.0	null
delsoline-7212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WH7G-2026-SM-3NMBL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986494
lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.131034
17002788-Table2	GeneSigDB Published Gene Signatures	1.0	null
C15orf40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13896
BTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31316
ARL4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95341
GTEX-P78B-2226-SM-3P5ZZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23304
endometrial stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.249653
eldeline-3925	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLF2_02_29	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.41504
PMC8891017-41586_2022_4394_MOESM4_ESM.xlsx-ST6_-_MAF_enrichment-Unnamed_4_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Frontal pole, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18226
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44322
Sarcoma_SARC_TCGA-X6-A8C7-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96239538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54067
SLC7A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30726
BRD-K10696228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07678
BRD-K61486072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22604
oxetacaine-4246	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bipolar disorder	GWASdb SNP-Disease Associations	1.0	1.83661
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.0202
mantle zone of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33714
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85119
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.774
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K15675930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26789
Hindlimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.127
PLXNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41489
PMC6987486__F2	PFOCR Pathway Figure Associations 2023	1.0	null
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.997791
BRD-K64904523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46349
BRD-K95860374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72338
ADAMTS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02277
mature	GeneRIF Biological Term Annotations	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.2037
regulation of cell death	GO Biological Process Annotations 2015	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12943
Perturb_8384_KO_LSD1_DRP006351	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.96997
Posterior limiting nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17631
EFNA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83218
HCT-116	GDSC Cell Line Gene Expression Profiles	1.0	2.51892
NDUFAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32608
NUDT19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20843
BRD-K31554491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35371
LIN7C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81913
E2F5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24337
wnt10a	GeneRIF Biological Term Annotations	1.0	null
flutamide-3885	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.737
Perturb_4276_KO_Smad2/Smad3_SRP132215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.90745
septostriatal transition area (accumbens)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01293
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
hydroflumethiazide-7259	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-200c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
col10	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.765
KLF6-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82992
H9 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.76982
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
benzthiazide-2989	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7523-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
receptor binding	GO Molecular Function Annotations 2015	1.0	null
Spindle pole centrosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.684
regulation of phosphorylation	GO Biological Process Annotations 2015	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870299
BRD-K39107553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17107
BRD-K36627718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32412
NCIN87	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63531
ATIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56334
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4731-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5813
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFYA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68629
BRD-K87146261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05802
Rickets	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
Floor plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.922
PMC9792765-Table_1.DOCX-0-TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
sulfaquinoxaline-2528	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4453609-bjc2014560x10.xls-Sheet1-HCT116_SMAD4_SMAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87412,GSE92423_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
phenelzine-3884	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5589252__F6	PFOCR Pathway Figure Associations 2024	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89537738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45241
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.42
diethylstilbestrol-3895	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE196699_7_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAB35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.756
PLPPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79447
RPRD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72365
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC8482521-mmc10.xlsx-Upstreme_Regulators_48_hr_MLR-Unnamed_0_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Bed nuclei of the stria terminalis, anterior division, anteromedial area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67235
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880191
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
B3GNT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79999
elevating	GeneRIF Biological Term Annotations	1.0	null
CDK8_knockdown_161_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.63817
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BMI1-19503595-MEFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K92079609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15061
3-nitropropionic acid-6402	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.170405
phenformin-3622	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
conserved	GeneRIF Biological Term Annotations	1.0	null
Vertebral endplate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.03
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1174
t2d	GeneRIF Biological Term Annotations	1.0	null
NCI-H226Br cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.976
GTEX-S33H-2426-SM-2XCB2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
hsa-miR-569	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0755
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
GSE193351_4_v_9_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87377
esculetin-3120	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X8HC-2726-SM-46MUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Brain_CT2_MGE 258	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855706
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898616
H4C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66766
saquinavir-6246	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12629
melanogenesis	KEGG Pathways	1.0	null
496100430_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.43409
BRD-K51697562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67704
Cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.309
years	GeneRIF Biological Term Annotations	1.0	null
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
TPRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.804
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.52693
GTEX-W5WG-1826-SM-4KL2Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27709
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_1169_KD_CBFB_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC8808015__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MON1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24841
GTEX-T2YK-2226-SM-32QPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K41355839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01627
BRD-K43918778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06886
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
0179445-0000-3633	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
negative regulation of apoptotic process	GO Biological Process Annotations 2025	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RBM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71002
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92581247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22091
cellular response to oxidative stress	GO Biological Process Annotations 2023	1.0	null
NAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12169
hsa-miR-4507	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
decreased bone strength	MGI Mouse Phenotype Associations 2023	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bone mineral density (femoral neck)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
tcf7l2	GeneRIF Biological Term Annotations	1.0	null
Female urethra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.82
regulation of stress-activated mapk cascade	GO Biological Process Annotations 2015	1.0	null
NDUFAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63265
GTEX-RNOR-0126-SM-2TF57	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18613
Bone Mineral Density Test	DisGeNET Gene-Phenotype Associations	1.0	null
LU-99A	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51557
Orbital area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89289
PMC6888566__F4	PFOCR Pathway Figure Associations 2023	1.0	null
SK-OV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64201
CHRDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24296
C19orf44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13757
NOP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03072
Ciliated epithelial cell_Esophagus_Human	CellMarker Gene-Cell Type Associations	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NF-A4X2-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97073
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
temporal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08858
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0244
adipiodone-3111	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dental pulp	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.179408
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065465
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21531
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847697
SFRP5	Pathway Commons Protein-Protein Interactions	1.0	null
BTRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44794
H3K27me3_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1563	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54491
cervix uteri	GTEx Tissue Gene Expression Profiles	1.0	1.12165
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67657
GTEX-QEL4-0726-SM-3GIJ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K30462643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46625
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.46035
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.43033
GTEX-PWCY-2126-SM-48TEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
DNAJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1059
normal	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-3646	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Perturb_16969_KD_AJUBA_SRP253076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.3332
TMEM14C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85943
keratinocyte proliferation	GO Biological Process Annotations 2025	1.0	null
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WY7C-2126-SM-3NB2R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68401
GSE122101,GSE122103_3_v_4_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24297
ficolin-1-rich granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.856
TMEM30B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14783
Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
mTOR signaling pathway	KEGG Pathways 2026	1.0	null
OB granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30804
cloxacillin-2289	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTIP_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
ITGA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97667
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of phosphatidylinositol 3-kinase signaling	GO Biological Process Annotations 2015	1.0	null
Mesenchymal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.978
BCL6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Polycystic kidney disease pathway	WikiPathways Pathways 2024	1.0	null
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WDR35	Pathway Commons Protein-Protein Interactions	1.0	null
KNS81	DepMap CRISPR Gene Dependency	1.0	2.43704
PMC8717717__F2	PFOCR Pathway Figure Associations 2024	1.0	null
r4 part of descending trigeminal sensory nucleus, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29269
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.930309
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
PPP1R3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96708
leukopenia	GWASdb SNP-Disease Associations	1.0	0.342996
GTEX-XUZC-1626-SM-4BRVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
nizatidine-5406	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SUZ12-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
phenacetin-2471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.1556
BRD-K13076765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38587
TBX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12984
GTEX-U412-0426-SM-3DB9O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07653
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	GO Biological Process Annotations 2025	1.0	null
SOX13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93574
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.011
HAND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39704
RD	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52287
SW-1353 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
pirenperone-2455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3395
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29382
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
DICER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14569
BRD-K95435237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19651
MYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16761
18704457-Table2	GeneSigDB Published Gene Signatures	1.0	null
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2859
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.03562
periventricular stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45335
activate	GeneRIF Biological Term Annotations	1.0	null
BRD-K79152256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09043
Chronic Lymphocytic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
cloxacillin-7483	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TSE9-0126-SM-3DB83	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949963
Forearm bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.5
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
tarsal bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.469599
cerebellar cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	3.01133
mesalazine-6162	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
wnt3	GeneRIF Biological Term Annotations	1.0	null
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827041
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCDH9	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF512	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86881
bone remodeling disease	GWASdb SNP-Disease Associations	1.0	1.91335
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.68055
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7162
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4889-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TML8-0926-SM-4DXSJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-T6MN-0826-SM-32PM4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827401
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22034
generation of neurons	GO Biological Process Annotations 2023	1.0	null
neuron differentiation	GO Biological Process Annotations 2025	1.0	null
DPAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16035
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.506279
BRD-K00789767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53503
flunisolide-3828	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2478
pentolonium-2305	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE193351_1_v_9_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ileocecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.133739
ciliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.499615
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
FKBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59126
GNA11	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K93774122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13352
GLOD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03445
Perturb_1122_KD_E2APBX1_SRP115954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45891
BRD-K93159873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0859
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
ZNF493	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25557
Uterine benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
cingulate gyrus, retrosplenial part, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.951127
extracellular matrix	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
C1orf109	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20626
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63994
meteneprost-7552	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
megestrol-3091	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ACKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31968
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52866
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mexiletine-3973	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
l35	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
Perturb_9596_KO_Prox1_SRP176286	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.07788
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.413532
USP48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57371
TACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43145
Dendritic spine neck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.897
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4038
BRD-K12064774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51266
thus	GeneRIF Biological Term Annotations	1.0	null
LTBR_INHIBITION - 27 Day_GDS2004_736_mouse_Lymph nodes  (MG-430A)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Proteoglycans in cancer	KEGG Pathways 2026	1.0	null
mRNA_CBX8_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
keratinocyte differentiation	GO Biological Process Annotations 2025	1.0	null
mammary epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.095601
hmepc cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.273346
GSE113734_1_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Osteopetrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.614
SIGMAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32873
tauopathy	GWASdb SNP-Disease Associations	1.0	1.83661
GLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04828
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
SUZ12-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39746
PCNX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74889
RH30	CCLE Cell Line Gene Expression Profiles	-1.0	-2.42655
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65J-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
APLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.846
Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paracentral lobule, anterior part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.982485
GNG4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ3S-1326-SM-4BOPQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
phenformin-21	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSPYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39278
GSE202434,GSE202438_10_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
TLK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54787
Periodontium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.213
BRD-K34318928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54412
BRD-K15343767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41135
Thrombospondin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.337
senescence-associated heterochromatin focus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.757
KCTD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91449
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.419
COPG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69726
MTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5489
TRAF3IP3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
replicative	GeneRIF Biological Term Annotations	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879501
bicuculline-4397	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-873	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13405
BRD-K11757577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.81436
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
camptothecin-4541	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHWD-1826-SM-3LK6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26243
SMTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95441
Lateral septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00819
mantle zone of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01239
Bone mineral density (total hip)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.804576
5707885-6390	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7814
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.888181
GTEX-XV7Q-1826-SM-4BRUV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12501
TP53-20018659-R1E-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Cardinal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.097
BRD-K03884263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68165
superficial stratum of r7Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21175
chlorpromazine-6977	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE226249_0_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
placenta_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
GSE186440,GSE186443_1_v_7_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
HS695T	DepMap CRISPR Gene Dependency	1.0	2.62615
KIAA2026	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89814
Cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21969
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.243879
GSPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98969
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.478
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.985398
cancer	GWASdb SNP-Disease Associations	1.0	0.054418
regulation of intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AOB, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42967
ESR2	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K23585987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66267
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.979501
lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.12476
GTEX-WHPG-2326-SM-3NMBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GJD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34505
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism developmental process	GO Biological Process Annotations 2015	1.0	null
Osteoporosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1665
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
SPRED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31735
tanespimycin-5958	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sulfachlorpyridazine-2191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.798
ZNF496	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77624
GSE243491_1_v_0_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6085667__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Calvarium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.848
MITF_02_85	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.0
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841092
elevated	GeneRIF Biological Term Annotations	1.0	null
Preosteoclast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.305
LPS6	DepMap CRISPR Gene Dependency	1.0	3.16632
ANXA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38179
osteoporosis	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
Tendon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.736
HCC1569	CCLE Cell Line Gene CNV Profiles	1.0	1.7187
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.238406
ATXN2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86719
SET2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47052
BRD-K31780647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.74899
layer 2 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0239
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34091
NANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1239
tolmetin-4167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxidative stress-induced premature senescence	GO Biological Process Annotations 2023	1.0	null
PCGF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03756
cell aging	GO Biological Process Annotations 2015	1.0	null
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0296
PMC9124578__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.251
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PGBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3781
Myometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.042
ZNG1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33167
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.091019
bone resorption disease	GWASdb SNP-Disease Associations	1.0	2.56374
CHD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68981
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE166783_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
ICAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89788
CLPP_KO_GSE40207_392_mouse_Testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
critical	GeneRIF Biological Term Annotations	1.0	null
Uterine endometrial epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.82
SRF_KO_GDS3732_148_mouse_HSC	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843004
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MKN45	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
GSE249146_2_v_3_dusp6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.9903
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959372
SKBR3	CCLE Cell Line Gene CNV Profiles	1.0	2.34665
EFHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62874
intermediate stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00715
BRD-K38904629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40741
Perturb_15512_KD_FOXA1_SRP353748	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.22
BOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19253
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
carbenoxolone-3353	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.95209
remained	GeneRIF Biological Term Annotations	1.0	null
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.939186
BRD-K04877446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46025
Cancellous bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.477
Leukemogenesis	DisGeNET Gene-Disease Associations	1.0	null
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981148
TNFRSF8	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
t70-white-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.63201
4-Benzylpyridine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
death	GeneRIF Biological Term Annotations	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
VANGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48183
MZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.86987
decidua	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.362273
mammarygland.lact.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.835488
adherence	GeneRIF Biological Term Annotations	1.0	null
16611997-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
RANBP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17834
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
DIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00667
stress-induced premature senescence	GO Biological Process Annotations 2023	1.0	null
wortmannin-6202	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SPARC_Deficiency_GDS3636_524_mouse_Lens epithelium	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
follicle-stimulating hormone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
oxprenolol-7225	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K27035180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60929
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
BRD-K65737790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37674
uremia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.207245
Rheumatoid Arthritis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K72435943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.67322
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lateral dorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10681
FSBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95183
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K40061713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16852
PMC6257835__F7	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K58779593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30199
GATAD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65653
GTEX-OIZH-0126-SM-2HMIS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20945
allele	GeneRIF Biological Term Annotations	1.0	null
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CDCA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87035
Dorsal aorta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.69
positive regulation of intracellular signal transduction	GO Biological Process Annotations 2023	1.0	null
chr7_121301989_G_A_b38	GTEx eQTL 2025	1.0	3.45707
MRPS26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98974
GTEX-R55F-0126-SM-48FCK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15463
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.771
nucleus sagulum, deep part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51809
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPP1R26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30015
Stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.88
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44322
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08802
translation	GeneRIF Biological Term Annotations	1.0	null
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.977033
HS3ST3B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93463
INIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57183
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K50075939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24837
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GPX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4158
Breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
Hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.042
BRD-K01297681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23212
positive regulation of MAPK cascade	GO Biological Process Annotations 2025	1.0	null
NKX6-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.487027
GSE168097_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XYKS-1426-SM-4BRUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59506
BRD-K36376229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5002
ST-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
BRD-K70198986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14654
EP300-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K29260599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17352
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
skin	HPA Tissue Gene Expression Profiles	1.0	2.24804
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XGQ4-0126-SM-4AT4H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838942
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.55255
Fatty Liver	CTD Gene-Disease Associations	1.0	1.35444
MBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56933
CRCGN011_HEPG2_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3658
ventral subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07151
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-WEY5-2226-SM-3GILQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Osteoarthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.177
Orbital area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47923
Podosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.853
Posterior cardinal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.265
BRD-K11477112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07025
GSTP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87093
intermediate stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51809
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
ZNF296	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63157
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0951
Osteoporotic Fractures	HuGE Navigator Gene-Phenotype Associations	1.0	null
PMC5589252__F6	PFOCR Pathway Figure Associations 2023	1.0	null
LPIN1_OE_GDS2291_587_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K32702774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16801
DVL3	Pathway Commons Protein-Protein Interactions	1.0	null
CLDN18_KO_GSE48443_44_mouse_lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
EOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08903
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.08477
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.876552
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.850837
BRD-K93295557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86497
MYO18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37842
testosterone-2649	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.04757
quinisocaine-4791	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-548c-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.953845
mRNA_NANOG_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
regulator	GeneRIF Biological Term Annotations	1.0	null
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYVS-2126-SM-3NMA3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56521
SPTLC2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62575
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
BMP receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.864
BRD-K08829593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86031
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40971
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7713
ZDHHC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1614
positive regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
PMC7677084__F9	PFOCR Pathway Figure Associations 2023	1.0	null
PMC7320752__F6	PFOCR Pathway Figure Associations 2024	1.0	null
TRMT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37372
contains	GeneRIF Biological Term Annotations	1.0	null
BRD-K74811560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09596
ANAPC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15227
TMEM14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64407
BRD-K22940496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45465
SEPTIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69655
mRNA_RXRA_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98190019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43901
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34414
ZNF717	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52355
Dimeric IgA immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.902
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.3747
yolk sac	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.489057
C32	CCLE Cell Line Gene CNV Profiles	1.0	2.11905
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.394197
STK17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16897
Orbital area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.13034
BRD-K89992188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84304
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
BRD-K84158675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2246
Perturb_6364_KO_Gne_SRP234441	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.816
SLC45A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89689
junctions	GeneRIF Biological Term Annotations	1.0	null
PL4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.849585
BRD-K82401173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73355
kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046643
cell fate commitment	GO Biological Process Annotations 2015	1.0	null
breast adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.183835
GTEX-WEY5-0826-SM-4LMIH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81781
Sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
Human - Pancreas - L1 - schwann	HuBMAP Azimuth Cell Type Annotations	1.0	null
DCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90521
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08196
GNAQ	Pathway Commons Protein-Protein Interactions	1.0	null
MDA-MB-468	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K75206048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0661
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	136.77
GTEX-UJMC-0226-SM-4IHLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K53489056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30323
EIF3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2619
GTEX-NPJ7-0011-R1a-SM-3GACT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.161912
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Craniosynostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
BRD-K58534227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23723
SNAPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55154
uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.215147
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MIEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6612
VMRCLCD	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68856
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estrogenprogesterone	GeneRIF Biological Term Annotations	1.0	null
thioperamide-5635	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventral claustrum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66395
cellular process	GO Biological Process Annotations 2015	1.0	null
Mesendoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.151
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.08465
leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.326432
Uterine fibroid	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
bisacodyl-2435	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18285
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2163
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.790199
obstructive lung disease	GWASdb SNP-Disease Associations	1.0	0.342996
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.888758
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DHX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98672
affect	GeneRIF Biological Term Annotations	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.172
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12709
BRD-K36465335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18628
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06239
Limb bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.521
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81481
CRCGN015_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.30973
SAFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12149
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
orciprenaline-2485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Osteogenesis imperfecta type 15	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
TAF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71826
INSIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18876
GTEX-R55E-0826-SM-2TC5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046501
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945468
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16968
hyoscyamine-2108	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dapagliflozin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
action	GeneRIF Biological Term Annotations	1.0	null
CRCGN011_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43245
BRD-K28305165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42551
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7732
MMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56132
WDR20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11898
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03219
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MALME3M	DepMap CRISPR Gene Dependency	1.0	6.27117
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
AMH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37957
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.50813
chlorpromazine-5577	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.903049
RNF2-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
negative regulation of biological process	GO Biological Process Annotations 2015	1.0	null
DLG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88401
MAX	ENCODE Transcription Factor Targets	1.0	null
BRD-K29475348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09853
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.943997
POU2F3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4EP-0626-SM-3P621	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25593
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4U-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the skeletal system	GWASdb SNP-Phenotype Associations	1.0	0.312204
BRD-K87158974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7752
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Incisor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
BRD-K48147099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31632
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K18600476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29581
PTOV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82067
u266	HPA Cell Line Gene Expression Profiles	1.0	0.949901
dermal papilla	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.439123
upregulation	GeneRIF Biological Term Annotations	1.0	null
Clock controlled autophagy in bone metabolism	WikiPathways Pathways 2024	1.0	null
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10339
BRD-K79547691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04226
GSE183994_1_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AHRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96819
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
LRIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11967
BRD-K45508763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11683
pd5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.667
Bone mineral density (paediatric, lower limb)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.05229
instead	GeneRIF Biological Term Annotations	1.0	null
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081688
IGR1	DepMap CRISPR Gene Dependency	1.0	4.58668
Knee	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.864
meropenem-7180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K33953218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44284
CLPP_KO_GDS4791_104_mouse_testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Branchial arch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.167
GTEX-OXRO-0226-SM-3LK6F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
496100320_PCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08894
Osteoclast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.308
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Walking leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
superficial stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48327
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40836
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25559116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5418
BRD-K35369722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27704
BRD-K70276322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20509
CHEMBL513147	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.52
GTEX-TML8-1926-SM-32QOS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11596
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
18927307-tableS2	GeneSigDB Published Gene Signatures	1.0	null
Perturb_8948_Mut_RB1_SRP220467	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.4237
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6668
mRNA_DLX3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WYBS-0426-SM-3NM9M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824512
PMC7744330__F3	PFOCR Pathway Figure Associations 2024	1.0	null
ADGRG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79734
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.47574
epidermal cell differentiation	GO Biological Process Annotations 2015	1.0	null
Blastomere	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.279
positive regulation of phosphatidylinositol 3-kinase signaling	GO Biological Process Annotations 2015	1.0	null
CWC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61678
TRABD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69308
NAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1451
Bed nuclei of the stria terminalis, posterior division, principal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0765
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39087
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular developmental process	GO Biological Process Annotations 2015	1.0	null
BRD-K83690550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37298
vinblastine-7551	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LRCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55599
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.898629
GTEX-P4QT-0126-SM-2I3FL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21009
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62453
prdm1_00000000_e9dot5_placenta_lof_mouse_gpl6887_gse39584	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.0393
ZNF816	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22715
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.6508
TCF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3753
TCP10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26109
finasteride-6062	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWCY-1726-SM-48TD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33564
ERCC5	Pathway Commons Protein-Protein Interactions	1.0	null
6-benzylaminopurine-3726	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79627231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31153
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.86
PIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66409
C10orf95	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34634
mRNA_T_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.18193
CTNNB1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_17675_KO_Arid1a/Pten_SRP124590	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.0672
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.829402
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21877
tenoxicam-4102	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
positive regulation of phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
Tetraamelia syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.369
GNB2	Pathway Commons Protein-Protein Interactions	1.0	null
SNU626	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6734
BRD-K76539747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28138
C1orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69959
cefapirin-3471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCT116	CCLE Cell Line Gene Expression Profiles	1.0	2.13763
BMI1	ChEA Transcription Factor Targets	1.0	null
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.906
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.461
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.01935
RNASET2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35287
AMPK gamma-3_KO_GDS1938_163_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Bone properties (heel)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.43979
19840643-Table1	GeneSigDB Published Gene Signatures	1.0	null
CRCGN015_MCF10A_48H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10079
BRD-K58217579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88427
BRD-K50985475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57888
TPD52L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06997
PMC3905281__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77852
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
H3C7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19464
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
replicative senescence	GO Biological Process Annotations 2015	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46501
EID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95716
ANKRD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.57371
Human - Motor Cortex - Cluster - PVALB+ GAPDHP60+ Layer 5-6 GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
GTEX-Q2AH-1026-SM-48TZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
lymph node	HPA Tissue Gene Expression Profiles	1.0	0.90318
GTEX-R3RS-0126-SM-3GIJL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1
GSE113817_2_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE252857_2_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSMD1	Pathway Commons Protein-Protein Interactions	1.0	null
NUDT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95203
prostate	HPA Tissue Protein Expression Profiles	-1.0	-1.63275
RABEPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06907
SUDHL8	CCLE Cell Line Gene Expression Profiles	1.0	1.90628
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
mass	GeneRIF Biological Term Annotations	1.0	null
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Palate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.306
RCM1	DepMap CRISPR Gene Dependency	1.0	2.30958
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13758
santonin-3877	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal bone structure	MPO Gene-Phenotype Associations	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
cll	GeneRIF Biological Term Annotations	1.0	null
CORL279	CCLE Cell Line Gene Expression Profiles	1.0	1.68144
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1993	DepMap CRISPR Gene Dependency	1.0	17.2738
MBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02
GNG10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13317726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15719
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908221
SP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77759
hsa-miR-3914	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
METTL25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36561
DVL1	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACHE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76667
BRD-K86937728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3479
GSE164874_5_v_7_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPUSD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13238
regulation of cellular response to stress	GO Biological Process Annotations 2015	1.0	null
BRD-K41662297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67706
HNRNPAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35582
PF-00875133-00-5967	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STK17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86404
GTEX-WK11-2726-SM-3NMAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.65353
cell part	GO Cellular Component Annotations 2015	1.0	null
Nymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
SLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72397
GTEX-QDVN-0626-SM-2I3FP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868036
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11995
gallamine triethiodide-2221	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HMX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16468
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3503
age	GeneRIF Biological Term Annotations	1.0	null
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
cytokine activity	GO Molecular Function Annotations 2023	1.0	null
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FAM193A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35097
Tacrine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.32
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
MTF2	ChEA Transcription Factor Targets	1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6572-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28271
ABRAXAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12141
cetirizine-2468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
oxidative stress-induced premature senescence	GO Biological Process Annotations 2025	1.0	null
glucocorticoid-induced osteoporosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.665
SOX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94505
Perturb_6879_KD_LINC00857_SRP371132	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.80204
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.498
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28621
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	79.5383
emx2_20962046_e10dot5_urogenital_epithelium_lof_mouse_gpl1261_gds3173	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.118395
immune system cancer	GWASdb SNP-Disease Associations	1.0	0.176194
PMC4848140-NIHMS766301-supplement-9.xlsx-Role_of_NANOG_in_ESC_DE-Unnamed_31_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
Somite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.869
BICRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49341
GTEX-OHPL-0126-SM-2HMJ7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44159
halofantrine-3130	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TBL1XR1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAPK14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63852
PMC7828172__F2	PFOCR Pathway Figure Associations 2024	1.0	null
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.88749
GSE89018_11_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
fluphenazine-4461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MOSMO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86251
PMC11686076-41598_2024_83268_MOESM1_ESM.docx-0-TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
RBBP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77804
RPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40092
BRD-K28140029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3973
Medulloblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
TPCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99667
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876381
bronchial disease	GWASdb SNP-Disease Associations	1.0	0.565675
B3GNT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44969
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
KMT2B	Pathway Commons Protein-Protein Interactions	1.0	null
B3GAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12046
ciclopirox-2456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XOT4-1426-SM-4B65T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832499
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.277
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
clomifene-6648	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01189
osteoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.328628
TARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07489
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63227
GTEX-WZTO-0126-SM-3NM95	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36656
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K90882192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46861
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.824953
Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Complex of collagen trimers	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.176
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37469
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC4271318__F8	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K14383477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20342
Lateral cuneiform bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
renal	GAD High Level Gene-Disease Associations	1.0	0.293278
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21657
PMC5960217__F4	PFOCR Pathway Figure Associations 2024	1.0	null
BMI1_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
BRD-K73697974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52825
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K67126097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26727
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13819
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5045
Leiomyoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0495
GTEX-RU72-1226-SM-2TF6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
EPHB6	Pathway Commons Protein-Protein Interactions	1.0	null
Phenylephrine infusion rate during anesthesia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
external male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.122268
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
CLPP_KO_GDS4791_537_mouse_testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
LYSMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90691
TBP	ENCODE Transcription Factor Targets	1.0	null
BRD-K56065989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5727
BRD-K14449601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20608
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K17152303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01975
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nicotinic acid-3381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XPVG-2126-SM-4B667	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00369
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
Tachycardia_Myocardial tissue_GSE7999	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.06536
PMC12480273-12672_2025_3611_MOESM1_ESM.xlsx-csgene-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75136523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24997
BRD-K98938484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29892
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JY-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCAR5	CCLE Cell Line Gene CNV Profiles	1.0	1.47552
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.08367
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
Matrilin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.306
hsa-miR-548e	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
GTEX-Q2AG-0126-SM-33HBV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50564
BRD-K51498205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67484
WNT ligand biogenesis and trafficking	Reactome Pathways 2024	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31462
ANKRD13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33042
CAL120	CCLE Cell Line Gene Expression Profiles	1.0	1.79432
BRD-K90366266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.81254
DPY30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28789
intracellular part	GO Cellular Component Annotations 2015	1.0	null
t67-small-intestine_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.60434
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2992
intermediate stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23303
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.075823
hsa-miR-590-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GLCCI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58724
Perturb_10200_KD_HNRNPUL1_ERP118119	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RAB8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46424
KASUMI2	CCLE Cell Line Gene Expression Profiles	1.0	3.40682
GTEX-RTLS-0326-SM-2TF6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
CCD-18Co cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
GTEX-T5JW-0726-SM-4DM6D	GTEx Tissue Sample Gene Expression Profiles	1.0	3.10661
Pathways of neurodegeneration - multiple diseases	KEGG Pathways 2026	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.424765
GTEX-XUZC-1026-SM-4BOPY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.546
BRD-K70941976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05002
tendon sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.277197
BRD-K43729445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09653
NFKBIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80646
connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.009804
RUBCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17434
sulfadimidine-3940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WQUQ-0426-SM-3MJFU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0576
SEMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05634
mefenamic acid-5109	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76588804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81659
GTEX-QDT8-0626-SM-48TYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEC31A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23271
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16748
USP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09168
GTEX-X4EO-0326-SM-3P5YO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57219
periosteum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.464948
GTEX-UPK5-0426-SM-3GAEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28494
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.55255
Adult Acute Lymphocytic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K56591923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43892
acetylsalicylic acid-5564	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCCSUP	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02611
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A5KG-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BMI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51158
ALS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10447
EHMT1	Pathway Commons Protein-Protein Interactions	1.0	null
TMEM132B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79562
anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20698
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0532
GSE179880_10_v_13_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.795
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
TP53-20018659-R1E-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Stromal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.805
BRD-K20799008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55107
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
butoconazole-2427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-3163	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04983
RAB3A_Mutation - D77G point mutation_GDS2482_704_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-SSA3-0226-SM-32QPN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02575
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
DACT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15857
myosmine-2199	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
liver	HPA Tissue Gene Expression Profiles	-1.0	-0.845616
GSE196540,GSE196542_4_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-M01343043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.52182
TMEM259	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5877
ALG13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06482
PHC1-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Prestwick-920-3118	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
BRD-K59919062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42505
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.507064
parastrial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46297
proteinaceous extracellular matrix	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K88583132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00102
KDM1A	ENCODE Transcription Factor Targets	1.0	null
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
DYNC1LI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17983
IRF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40249
trimethobenzamide-1920	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mantle zone of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00767
Osteogenic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.714
PMC11814291-41698_2025_830_MOESM1_ESM.pdf-4-KLF14_KLF14	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WM-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pontine raphe nucleus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.54607
RMUGS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32628
COMTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88808
BRD-K95574976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17844
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
IGROV1	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.902502
PAXBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29127
BRD-K95171874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19849
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CE-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bone resorption disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
TUHR14TKB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.675
Pictilisib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.07
Coronary Heart Disease	DisGeNET Gene-Disease Associations	1.0	null
positive regulation of intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
superficial stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10138
finasteride-3641	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Female pronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.552
sulfabenzamide-2159	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
valinomycin-5962	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q2AI-1326-SM-2S1PL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01801
gemcitabine_homo sapiens_gpl96_gse6914	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40797
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84845
IDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01472
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03193
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.202684
BCL11A	Pathway Commons Protein-Protein Interactions	1.0	null
promazine-3833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
breast epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08811
GTEX-R55G-2526-SM-2TC6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02271
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
bone remodeling	GO Biological Process Annotations 2015	1.0	null
EHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14153
lateral anterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1126
MRPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30043
PHLDA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21569
PC3-MM2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.54
Anterior olfactory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13251
BRD-K48634117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04956
ATP6AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64522
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18168
PMC4271318__F8	PFOCR Pathway Figure Associations 2024	1.0	null
Dorsal column nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23823
BRD-K49745710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42624
EBF1	Pathway Commons Protein-Protein Interactions	1.0	null
GM2493	BioGPS Cell Line Gene Expression Profiles	1.0	0.915343
Prestwick-691-4172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10328
ZNFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19589
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78715
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X5EB-2226-SM-46MW4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1404
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.646938
ribavirin-3142	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
heart_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5630-01A-01R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-543	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Calcaneal bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.888
BRD-K39078753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15386
Perturb_9099_KD_SSX_SRP128693	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.46026
response to stimulus	GO Biological Process Annotations 2015	1.0	null
SLC52A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49491
FAM162A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3132
HDAC6	ENCODE Transcription Factor Targets	1.0	null
BRD-K01237500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11051
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
atropine oxide-6812	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03693
GTEX-S341-0126-SM-4AD64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891426
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39W-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37949240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24454
brownfat	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.77228
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.57391
acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23961
Paraventricular hypothalamic nucleus, descending division, lateral parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61055
GTEX-WH7G-0326-SM-3NMBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.895175
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.508
Nucleus sagulum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5577
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81673
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.02743
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TE14	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32483
Lung adenocarcinoma_LUAD_TCGA-64-5779-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE261563_2_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31269097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10577
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.427
C14orf28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37053
GNPTAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64582
ATXN1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92314
BRD-K49424866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56559
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.861131
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
substantia innominata/basal nucleus, transitional part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11147
RH-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43216
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42326
GTEX-WRHU-2826-SM-3MJG8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.45711
insertion	GeneRIF Biological Term Annotations	1.0	null
BRD-K51320582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0171
reduced	GeneRIF Biological Term Annotations	1.0	null
GTEX-S341-0226-SM-2XCAX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
NKRF	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.566
GTEX-XOTO-0126-SM-4B66N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31498
EOL-1-CELL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
metoprolol-4508	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T5JC-0426-SM-32PLO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901634
BRD-K07697589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42754
UQCR10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57224
BRD-K11835238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82331
BRD-K09903493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32992
MACROH2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45983
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	120.568
SARAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76214
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.02077
GSE213632_1_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04081
craniofacial region	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.350372
GTEX-R55E-0426-SM-2TC65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
lung disease	GWASdb SNP-Disease Associations	1.0	0.193511
BRD-K64353626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48458
BRD-K84090286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.83629
Chondroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.973
impact	GeneRIF Biological Term Annotations	1.0	null
decreased compact bone thickness	MPO Gene-Phenotype Associations	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0819
PMC3686512__F1	PFOCR Pathway Figure Associations 2023	1.0	null
Meniscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.67
spinal column	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121851
sulfapyridine-6101	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61044
Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CP-673451	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.06
SMAD4-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Breast cancer pathway	WikiPathways Pathways 2024	1.0	null
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.503
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral isthmic part of the dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01452
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.86347
Proboscis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.782
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66949
BRD-K95499061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10552
KSR2_knockout_60_GSE17923	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.87384
PPP2R2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20969
BRD-K94775036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52392
ZNF829	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49497
2-Cl-IB-MECA	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
CRCGN015_MCF10A.TP53.M_24H:J05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08355
ERAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47215
BRD-K56531121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98413
pallidal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10478
blastodisc	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.171111
GTEX-WCDI-0426-SM-4GIAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
thyroid gland	HPA Tissue Gene Expression Profiles	-1.0	-1.17326
BRD-K37831546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44901
ASNSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55223
KRAS.BREAST_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
hsa-miR-200b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
UBTF	ENCODE Transcription Factor Targets	1.0	null
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.222442
betonicine-3642	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05509844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30752
hsa-miR-3940-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.102398
canonical	GeneRIF Biological Term Annotations	1.0	null
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01355
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.389653
GTEx Lung 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	6.7001
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21889
intermediate stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.092
GSE167373_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.22048
BRD-K28349636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.25197
BRD-K70518736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12088
FLI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42195
TYMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68373
trimethadione-2486	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
MFGE8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50723
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of signal transduction	GO Biological Process Annotations 2025	1.0	null
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062617
Female reproductive organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
ratio	GeneRIF Biological Term Annotations	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MSX1_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
NAPRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67408
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39333
Cancer pathways	WikiPathways Pathways 2024	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.665
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
GTEX-X8HC-2826-SM-46MWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02442
BRD-K21332842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08234
Hippo signaling pathway	KEGG Pathways 2026	1.0	null
lateral septal nucleus, intermedio-intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03013
CTTNBP2NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0107
Jaw	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.617
terfenadine-1381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBXN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17196
skin_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.68423
BRD-K48407262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22294
GSE164874_5_v_8_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PCYT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25427
PMC5722545-oncotarget-08-97061-s004.xlsx-Sheet1-Supplementary_Table_4_Differentially_expressed_genes_after_knockdown_of_FOXM1_with_siRNA_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
MDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76759
PARL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64439
ZC3H7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4411
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bed nucleus of the stria terminalis, medioseptal division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72602
PMC10107781-NAN-49-0-s002.xlsx-NGS68_MBNL2_KO-vs-WT_log2FC0-4-symbol_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
TE5	CCLE Cell Line Gene CNV Profiles	-1.0	-2.75536
L-168,049	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
velnacrine-4997	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28603
GTEX-PLZ6-1426-SM-2S1OQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18272
59M	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43613
BRD-K67442425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.026
GTEX-SJXC-0126-SM-2XCFF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05108
receptor ligand activity	GO Molecular Function Annotations 2025	1.0	null
SLC17A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10644
palmatine-2138	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
stratum pyramidale of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.828616
fracture	GeneRIF Biological Term Annotations	1.0	null
PMC5677954-41536_2017_9_MOESM2_ESM.csv--STAT1_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K45328741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01249
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5441-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K12665145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12776
EEF2KMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40706
lens	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.176116
extracellular matrix	GO Cellular Component Annotations 2015	1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.9603
bone disease	GWASdb SNP-Disease Associations	1.0	0.600695
18338247-SuppTable4B	GeneSigDB Published Gene Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5035-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.3
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11568168-41598_2024_79607_MOESM3_ESM.xls-11-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
dacarbazine-2754	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Exoskeleton	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.653
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EXTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34479
intermediate stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38963
fat_x1.V2	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
Perturb_6795_Mut_MYC_SRP060721	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.3403
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Renal fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
PMC6257835__F7	PFOCR Pathway Figure Associations 2023	1.0	null
Osteoporosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.222
hsa-miR-1200	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
LYRM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89123
Mammary Paget's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
Sclerotome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.672
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.38975
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870855
basolateral amygdaloid nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24932
co-dergocrine mesilate-4152	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Synovial fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.166
ZNF836	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66064
BRD-K68823900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8432
delsoline-2513	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06431655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05691
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4244
Arrector pili muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
regulation of phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
pre-b acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.163518
Exostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
lycorine-3891	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
penis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.138525
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.854236
hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.189948
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.8135
Hemorrhage	CTD Gene-Disease Associations	1.0	1.05015
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6861_KO_CDK19_SRP299261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.405
CDC14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12846
Signaling by WNT in cancer	Reactome Pathways 2014	1.0	null
Childhood Acute Lymphoblastic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
Pronephric duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.097
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V1D1-2226-SM-3NMAX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10454
trichostatin A-3114	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rosiglitazone-369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01388
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09549
ZNF180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87332
GTEX-UJHI-1326-SM-4IHJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03187
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HOXB8_HOXB8	Rummagene Transcription Factor Associations 2026	1.0	null
Pharyngeal arch cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35132
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X261-0126-SM-3NMD6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04659
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.813
PMC8567035-CTM2-11-e578-s002.xlsx-breast_cancer-ESR1_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0068
p3 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00617
levonorgestrel-4269	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K21124684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9084
Skin carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
Dasatinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.85
BRD-K40841951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2143
BRD-K54637865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44492
GNA15	Pathway Commons Protein-Protein Interactions	1.0	null
LN382	CCLE Cell Line Gene CNV Profiles	1.0	1.39314
GTEX-OHPL-1326-SM-3MJGG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
EIF4ENIF1	Pathway Commons Protein-Protein Interactions	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9907
Lateral septal nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44168
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.82055
betacatenin	GeneRIF Biological Term Annotations	1.0	null
KISS1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06481
PMC11237033-41419_2024_6873_MOESM3_ESM.xls-Supplementary_Appendix_2-BHLHE40_BHLHE40	Rummagene Transcription Factor Associations 2026	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067193
BRD-K40862705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75603
Ischemic heart disease in rheumatoid arthritis	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
GTEX-XUW1-0326-SM-4BOOR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01324
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE230263,GSE230265_5_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89668690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39355
GTEX-X8HC-0626-SM-4E3HQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940739
Osteocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.209
Mineral metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RING1B-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ALKBH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60795
valproic acid-6974	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KRAS.LUNG_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990385
uterine epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.370121
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27849
BRD-K45984211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93141
STPG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37937
BRD-A56345662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07533
CRCGN011_HEPG2_24H:F06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36685
PPARGC1A	Pathway Commons Protein-Protein Interactions	1.0	null
Alveolar bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.265
BRD-K33940145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66403
HSPA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32633
GTEX-X8HC-0226-SM-4E3K1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
prochlorperazine-455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9684
IVNS1ABP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80791
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12959
PMC6870463-Table_7.xlsx-Family_H_No_LPS-Untreated_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UBE2E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80705
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.04061
hsa-miR-4753-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
step	GeneRIF Biological Term Annotations	1.0	null
BRD-K93460493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71975
Cyanuric chloride	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
Vitelliform Macular Dystrophy	DisGeNET Gene-Disease Associations	1.0	null
Signaling by Wnt	Reactome Pathways 2014	1.0	null
Myometrial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.993
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	Reactome Pathways 2014	1.0	null
hsa-miR-1233	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.866
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55133
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DHX57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67382
MMP17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1942
gastrula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.31877
NDUFB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76777
BRD-A71722688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1611
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093391
BRD-K96547094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05777
SAP30BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33334
cytokine activity	GO Molecular Function Annotations 2025	1.0	null
PSKH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55992
PECAPJ49	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36432
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873056
Neural plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.189
temporal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19932
BRD-K62170825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11965
Mandibular ramus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.683
hair follicle bulge stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.857995
neuron differentiation	GO Biological Process Annotations 2023	1.0	null
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9302
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.058446
SB 216763	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.89
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7762413__F1	PFOCR Pathway Figure Associations 2023	1.0	null
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.12114
fursultiamine-2929	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
orphenadrine-3883	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7701-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-6560-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87653
TENM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21929
cell differentiation	GO Biological Process Annotations 2015	1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21132
Schinzel type phocomelia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
ZBTB41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15703
regulation of gene expression	GO Biological Process Annotations 2025	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K02050740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55429
GTEX-O5YW-0126-SM-3LK6D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897703
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
GTEX-PSDG-0226-SM-33HC1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14267
OVSAHO	CCLE Cell Line Gene CNV Profiles	1.0	1.33188
BCB000040-7554	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7178-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
HS695T	CCLE Cell Line Gene CNV Profiles	1.0	1.33661
CJ-42794	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
L-methionine sulfoximine-4070	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
epidermal cell differentiation	GO Biological Process Annotations 2023	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
HBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60802
PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.476985
Bed nuclei of the stria terminalis, anterior division, magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57335
valproic acid-4433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
ZNF471	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49761
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.850837
B4GAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67524
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the cerebrum	GWASdb SNP-Phenotype Associations	1.0	0.425394
mammary paget's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.300533
homosalate-3879	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
aberrant	GeneRIF Biological Term Annotations	1.0	null
abnormality of lymphocytes	GWASdb SNP-Phenotype Associations	1.0	0.481935
GTEX-QCQG-0126-SM-48U27	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
TMEM263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88813
H2AC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47255
OARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53019
hsa-miR-4719	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8441
6-benzylaminopurine-3623	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-KT-A7W1-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Basal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.452
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.502
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892488
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
paromomycin-3017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
microenvironment	GeneRIF Biological Term Annotations	1.0	null
TCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21386
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Exudative vitreoretinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.38665
BRD-K81656074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57038
haloperidol-4468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cleft lip	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
HMEpC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	4.38324
BRD-K16264250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06699
PEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75298
BRD-K97224540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07696
GTEX-U8T8-0126-SM-3DB94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3156
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.17567
BRD-K77845452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08465
MTRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48474
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Pitolisant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
dextromethorphan-2636	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
precentral gyrus, right, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.947377
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81127
BRD-K07414059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40113
COLO679	CCLE Cell Line Gene CNV Profiles	1.0	1.6751
Dipyridamole	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
Forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.147
PIAS1-25552417-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K32712332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3039
decreased compact bone area	MPO Gene-Phenotype Associations	1.0	null
kidney	HPA Tissue Protein Expression Profiles	1.0	0.821986
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6940-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CW-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.955739
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.434
FIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87066
NIHOVCAR3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.01203
dorsal peduncular cortex, periventricular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.51364
pretectal region	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.835748
parahippocampal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05963
g-protein coupled receptor binding	GO Molecular Function Annotations 2015	1.0	null
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.826622
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
netilmicin-6005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CRCGN015_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0193
EP300	ChEA Transcription Factor Targets	1.0	null
pre-B-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.408
r9 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65398
Developmental and epileptic encephalopathy 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
PPFIA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66141
Phosphorus metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
RCH-ACV cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.842
GTEX-RU1J-0326-SM-46MUM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Disease	Reactome Pathways 2014	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.46178
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5455
GTEX-T2IS-0126-SM-4DM6O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04232
BRD-K14037093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37525
Blastema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
Ro-3306	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.82
NCIH1930	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47234
canonical Wnt signaling pathway	GO Biological Process Annotations 2023	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00016
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Perturb_16422_KO_Ring1/Rnf2_SRP136552	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.8663
THUMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46398
CGAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73648
peduncular nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05048
PMC10870497-13046_2024_2976_MOESM12_ESM.pdf-20-FOXD1_FOXD1	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.197662
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27722
pempidine-2172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PU.1	MotifMap Predicted Transcription Factor Targets	1.0	null
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-QVJO-1826-SM-447C9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
DELE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83602
hsa-miR-4679	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-XQ3S-1426-SM-4BOPR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43441
Perturb_1121_KD_E2APBX1_SRP115954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.03885
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anatomical structure formation involved in morphogenesis	GO Biological Process Annotations 2015	1.0	null
amiprilose-4119	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37658621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36991
Perturb_13091_KO_Atmin_SRP062722	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
BRD-K54042694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74717
Neural ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.631
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2116
BRD-K56857396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01986
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912119
KRT19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41478
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CFPAC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.00605
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.056
GTEX-X4EO-2926-SM-4E3JH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86539
NCI-H1993	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
BRD-K82922770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60692
PCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00989
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0475
methylbenzethonium chloride-3850	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
SF3B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38846
RCHACV	CCLE Cell Line Gene Expression Profiles	1.0	2.40873
dexamethasone_homo sapiens_gpl6244_gse20963	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nerve cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
GPRASP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91158
benzamil-3738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Vertebra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.947
GTEX-Q2AI-0226-SM-48U1D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
KIF13B	Pathway Commons Protein-Protein Interactions	1.0	null
MYL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4111
Wing	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.156
r9 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35466
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Stomach carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
CRTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62024
Perturb_1162_KD_E2APBX1_SRP115954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.4559
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.702308
BRD-K76763044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0459
18410693-TableS10	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
keratinocyte proliferation	GO Biological Process Annotations 2023	1.0	null
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32994
LY2090314	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.12
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52345
MC3T3-E1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.717
ZNF443	Pathway Commons Protein-Protein Interactions	1.0	null
somite	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.42993
GRIN2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21089
p2 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01665
hsa-miR-1279	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
cingulate gyrus, frontal part, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19729
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.936533
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111981
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33962
GTEX-UPIC-1626-SM-4IHKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953521
BRD-K54549319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10857
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
inner SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06441
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X62O-0126-SM-4E3JN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864009
BRD-K58996625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15338
Osteoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.475
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.8612
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.086721
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.8847
GTEX-XUJ4-2426-SM-4BOO3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882806
necessary	GeneRIF Biological Term Annotations	1.0	null
MESSA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62363
GNB3	Pathway Commons Protein-Protein Interactions	1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055654
BRD-K18978449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74916
Osteoporosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.612
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4287
r10 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19832
USP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71062
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20828
SYPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73464
Bladder Urothelial Carcinoma_BLCA_TCGA-LC-A66R-01A-41R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SDHD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17371
GNG12	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
HDAC4	Pathway Commons Protein-Protein Interactions	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.873999
RNASEH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95822
pi3kakt	GeneRIF Biological Term Annotations	1.0	null
cortico-medial group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05771
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal compact bone morphology	MPO Gene-Phenotype Associations	1.0	null
GTEX-XYKS-2126-SM-4E3IB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12845
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
eb-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.480091
ENSG00000284691	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30719
wnt4	GeneRIF Biological Term Annotations	1.0	null
preosteoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.145418
Callus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.405
BRD-K51600962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24702
DDIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06449
DGUOK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49457
BRD-K24343968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81623
HNF1A	Pathway Commons Protein-Protein Interactions	1.0	null
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95377
VMAC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55722
DNA Damage Response (only ATM dependent)(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4496	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K54538111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46177
GPCR ligand binding	Reactome Pathways 2014	1.0	null
DANG	CCLE Cell Line Gene CNV Profiles	1.0	2.18602
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
Bone Density	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06686
BRD-K08835142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45076
Degenerative Polyarthritis	DisGeNET Gene-Disease Associations	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.192746
r9 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23362
EEIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86131
BRD-K82935855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61806
JUN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43524
NNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27544
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9463
Bed nuclei of the stria terminalis, posterior division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00504
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
subjects	GeneRIF Biological Term Annotations	1.0	null
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17633
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.086721
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOP92	CCLE Cell Line Gene CNV Profiles	1.0	1.43156
AOB, mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37255
Subiculum, dorsal part, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03404
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.693
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
G361	CCLE Cell Line Gene CNV Profiles	1.0	1.39086
ARNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11138
NME6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90787
EMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87587
UBE2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63733
hsa-miR-4680-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
mRNA_SMAD1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
CD46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24435
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GATA3_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28268716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20022
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.25899
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
spleen_3a	HPA Tissue Sample Gene Expression Profiles	1.0	0.995162
osteoblastderived	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPIC-1426-SM-4IHLQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7103
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.1028
BRD-K09373762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33633
Perturb_14625_KO_OGT_SRP146064	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.36367
hsa-miR-4760-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Amylin receptor complex 1	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.63
ZNF146	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23078
aminophenazone-2222	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9456
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.659601
SF295	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56255
significant	GeneRIF Biological Term Annotations	1.0	null
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843539
LRRC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47499
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
signal transduction	GO Biological Process Annotations 2015	1.0	null
BRD-K65392908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67897
Human - Motor Cortex - Cross-Species Cluster - Pvalb+ GABAergic neuron_2	HuBMAP Azimuth Cell Type Annotations	1.0	null
Bone ultrasound measurement (broadband ultrasound attenuation)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.7
EP300-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Osteogenesis imperfecta type 20	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
trazodone-2379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FTC133	CCLE Cell Line Gene Expression Profiles	1.0	1.49885
hydralazine-2311	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_3933_KO_TFAP2A_SRP273704	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
skin development	GO Biological Process Annotations 2025	1.0	null
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.607
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
BRD-K62584372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34654
TMEM98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24459
inner SZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17511
carbarsone-4110	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058859
ZNF735	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03014
LTB4R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75568
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE140997_10_v_5_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02614439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12248
pre-b cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.524294
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE174498,GSE174500_2_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPM-0726-SM-3LK7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825094
lead	GeneRIF Biological Term Annotations	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K08212599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05587
VM-CUB-1	GDSC Cell Line Gene Expression Profiles	1.0	2.18176
PMC8803621-mmc5.xlsx-54JIB-04genes_w_GATA4_motif-GATA4_Q3_GATA4	Rummagene Transcription Factor Associations 2026	1.0	null
RVH421	DepMap CRISPR Gene Dependency	1.0	2.22466
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Tentacle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.123
SMNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21312
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.1929
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.735
Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63516
PMC10684125-cm9-136-2712-s001.xlsx-Sheet1-BHLHE40_BHLHE40	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2354
MAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70969
Tail fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.336
TAGLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74889
tacrine-2633	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6969-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Wnt Signaling Pathway and Pluripotency(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.69151
Anemia	CTD Gene-Disease Associations	1.0	1.16733
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.4452
hsa-miR-4742-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
medial geniculate nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0917
GTEX-T5JC-0526-SM-32PM7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
IRAK-1-4 Inhibitor I	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
BRD-K06174863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62505
NECTIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50243
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
cyclizine-5525	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.593
Mesenchymal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.775
GTEX-XQ8I-1726-SM-4BOQB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918992
BRD-K45367466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04936
GTEX-QV44-2226-SM-447A3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CNOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06211
FUT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05464
WDR48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62608
succinylsulfathiazole-2821	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.193511
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873056
ZNF677	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46827
dicoumarol-3941	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QDT8-0126-SM-48TZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13615
mammary epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.102275
KO52	CCLE Cell Line Gene CNV Profiles	-1.0	-2.17617
Diabetes Mellitus, Type 2	HuGE Navigator Gene-Phenotype Associations	1.0	null
abnormal skeleton physiology	MPO Gene-Phenotype Associations	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89781
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02705
BRD-K73768826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47881
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.851484
Bone mineral density (paediatric, lower limb)	GWAS Catalog SNP-Phenotype Associations	1.0	0.626595
Fuhrmann syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.441
female pudendum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.174447
RPH3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53027
ChIP_NR0B1_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
does	GeneRIF Biological Term Annotations	1.0	null
Anterior olfactory nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9808
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.809
Tooth bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053385
2-iodomelatonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3764
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	105.286
breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.064494
PMC3692130__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-WHSB-1326-SM-3LK6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59372
Ethoxzolamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
ChIP_H3K27me3_18600261_mouseWholeBrain	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.32628
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
variation	GeneRIF Biological Term Annotations	1.0	null
esculin-3390	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gelsemine-4177	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mesoridazine-1725	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMEM237	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17734
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ICAM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83792
locus	GeneRIF Biological Term Annotations	1.0	null
BRD-K52194153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09601
MCUR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75065
GTEX-WFG7-1826-SM-3GIL1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846213
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.07696
CREBZF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65516
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Wnt Signaling Pathway and Pluripotency(Mus musculus)	WikiPathways Pathways 2014	1.0	null
Signaling by GPCR	Reactome Pathways 2014	1.0	null
CRCGN014_HEPG2_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46525
retrotrapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87551
8305C	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72093
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090835
GSE138741,GSE138743_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIRT4_KO_GSE56321_391_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Human - Motor Cortex - Cluster - PVALB+ MEPE+ Layer 5-6 GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.96841
17148579-TableS3	GeneSigDB Published Gene Signatures	1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088385
Nucleolar ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.164
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.524
HEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39283
compared	GeneRIF Biological Term Annotations	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	175.027
DNA damage response only ATM dependent 	WikiPathways Pathways 2024	1.0	null
Forearm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.716
Precursor B-Cell Lymphoblastic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
canonical Wnt signaling pathway	GO Biological Process Annotations 2025	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
Brain Lower Grade Glioma_LGG_TCGA-DU-7013-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RELA_02_39	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.41504
CLPP_KO_GSE40207_388_mouse_testis	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HI-7168-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0942
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-SNOS-1726-SM-32PLN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K57115335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39856
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
striohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.98917
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963144
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
positive regulation of phosphorylation	GO Biological Process Annotations 2015	1.0	null
MDAMB436	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79601
NCIH1573	DepMap CRISPR Gene Dependency	1.0	2.99246
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12717
BRD-K48691065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2103
Bone mineral density (paediatric, total body less head)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.92218
URGCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5021
GADD45B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1655
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SYCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11375
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13625
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RHBDL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89598
PIAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46308
PPFIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92597
tacrolimus-284	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K54576503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59821
BRD-K05118964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53691
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
pre-b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.623043
GTEX-X638-0126-SM-47JZ8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05337
cellular component morphogenesis	GO Biological Process Annotations 2015	1.0	null
BRD-K06845853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29193
FOS	ENCODE Transcription Factor Targets	1.0	null
cdkn1b_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl6246_gse27672	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.176127
ZNF705D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79553
regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
PKBalpha_KO_GDS1784_193_mouse_Embryonic fibroblasts (MEFs) - 0 hour	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_3_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21692
Osteoarthritis, Knee	HuGE Navigator Gene-Phenotype Associations	1.0	null
Alzheimer 39 s disease	WikiPathways Pathways 2024	1.0	null
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
KCNA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9602
ncRNAs in Wnt signaling in hepatocellular carcinoma	WikiPathways Pathways 2024	1.0	null
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Lateral posterior nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19407
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
positive regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2025	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Parathyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
ALDH3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73839
GSE226249_2_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32723442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1989
t119positive	GeneRIF Biological Term Annotations	1.0	null
PLEKHG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27195
BRD-K45936761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50494
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7254-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44415
BRD-K84439371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31533
BRD-K59922784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10558
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3018
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.74
epirizole-5995	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
b-cell acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.463013
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.666
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8223
Sarcoma_SARC_TCGA-HS-A5N9-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1476
Periosteum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.477
sirolimus_mus musculus_gpl1261_gse21755	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GNG3	Pathway Commons Protein-Protein Interactions	1.0	null
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21398
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CXXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19571
BRD-K23316938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09484
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27023
preb	GeneRIF Biological Term Annotations	1.0	null
SARS-CoV MA15_Day1-PFU-10^4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52323
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
NPPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09419
ZNF845	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96376
GTEX-TML8-1526-SM-4DXUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
valproic acid-4446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
gramine-2143	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12875
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
calycanthine-1771	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PAGE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45006
positive regulation of JNK cascade	GO Biological Process Annotations 2025	1.0	null
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
Fractures	GWAS Catalog SNP-Phenotype Associations 2025	1.0	9.1699
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TTLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03314
sulfinpyrazone-6230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S33H-1126-SM-2XCB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.901278
pancuronium bromide-4393	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tamoxifen_homo sapiens_gpl570_gds4095	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
onset	GeneRIF Biological Term Annotations	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Epiphyseal growth plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.567
VIRMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03451
CREBBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.532701
EED-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.503
CNNM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88842
GSE203308_1_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesonephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.286
ALX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97056
Bone resorption disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.611
SLC12A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82785
HS618T	CCLE Cell Line Gene Expression Profiles	1.0	2.04754
amphotericin B-3303	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZMYM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51619
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25275
Lateral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02839
laminin-9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.995
hsa-miR-2964a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53109
Blastopore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.483
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08355
PMC7086291__F4	PFOCR Pathway Figure Associations 2023	1.0	null
Osteophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.711
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.86662
wnt5b	GeneRIF Biological Term Annotations	1.0	null
MYBL1_KO_GDS4485_350_mouse_Testis from 17 day old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
UM-UC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
trichostatin A-4348	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10107781-NAN-49-0-s002.xlsx-NGS68_MBNL2_KO-vs-WT_log2FC0-4-GRCh37_87_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
Junctional zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
AAAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9856
hsa-miR-520d-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tilorone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22755
Robinow syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
GSE125153_2_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
upper basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12105
Dopaminergic A13 group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69476
extracellular region	LOCATE Curated Protein Localization Annotations	1.0	null
Perturb_3720_KD_CHD4/DNMT1_SRP049370	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.44239
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.83432
ATRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56027
GEMIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6909
CP-863187-7553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFON-0526-SM-4LVLY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.55255
Tailbud stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
neuron differentiation	GO Biological Process Annotations 2015	1.0	null
quercetin-283	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
15902281-TableS1d	GeneSigDB Published Gene Signatures	1.0	null
burkitt lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.389666
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.996843
rara_21299862_mcf7_lof_human__gds4065	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.21571
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11408518-41598_2024_73146_MOESM5_ESM.xlsx-Intersection_gene-NCOA1_NCOA1	Rummagene Transcription Factor Associations 2026	1.0	null
UBXN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23421
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K88190816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17094
Craniodiaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
chondrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.464948
ESC Pluripotency Pathways(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Heel bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	10.0
GTEX-R55D-0826-SM-48FEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843902
GSE155031_6_v_2_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AOB, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07151
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
TRMU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45181
GTEX-QVUS-0011-R1A-SM-3GAD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889298
MANEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62891
nucleus of the stria terminalis, medial division, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85237
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870642
spectrin-associated cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.634
GSE157960_0_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203308_6_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.26433
Insect labium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
ABI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34139
ATF7	Pathway Commons Protein-Protein Interactions	1.0	null
Anterior cingulate area, ventral part, 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83742
hsa-miR-1305	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.536993
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.717882
GTEX-T8EM-1026-SM-3DB7M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30473
CHD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37094
BRD-K59747214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51712
fat_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
selegiline-2465	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bed nucleus of the stria terminalis, laterocentral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13742
GTEX-WFON-1826-SM-3GILG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
KDM4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8164
Osteogenic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.465
hsa-miR-107	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Osteoporosis	DisGeNET Gene-Disease Associations	1.0	null
PMC5727250__F1	PFOCR Pathway Figure Associations 2023	1.0	null
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
SIN3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79896
Osteosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.789
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.392629
BRD-K42671829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28876
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0726
FOXO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5313
SUZ12-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
inhibitory	GeneRIF Biological Term Annotations	1.0	null
SNRNP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33348
Cement gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1562
CORL311	DepMap CRISPR Gene Dependency	1.0	2.40287
adipose-derived stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.856
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837678
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dentate (lateral) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.832743
Skin epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.653
Hair follicle bulge	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
EED-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
19840643-Table2	GeneSigDB Published Gene Signatures	1.0	null
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067539
RNF31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09561
Intercalated disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.746
GTEX-XOT4-0626-SM-4B66L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09741
breast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057669
TET3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37345
CBX2	ENCODE Transcription Factor Targets	1.0	null
GTEX-SSA3-0126-SM-32QPU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84511
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050861
BRD-K45612428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35028
AQ-390/43364023	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
BRD-A42030853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39204
Pineal region germinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
pre-B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.167
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
schizophrenia	GWASdb SNP-Disease Associations	1.0	1.83661
GTEX-WY7C-2326-SM-3NB2U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26966
ventral isthmic part of dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02584
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12709
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SLC22A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99357
Cadherin signaling pathway	PANTHER Pathways	1.0	null
PPAP2B	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.92754
nisoxetine-3117	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
papaverine-1755	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nephrotome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.078
hecogenin-5818	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S4Z8-0426-SM-3K2AH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
hsa-miR-4251	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K34931072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35656
MATN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07547
mediates	GeneRIF Biological Term Annotations	1.0	null
C2orf69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97829
ChIP_EED_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
acetylsalicylic acid-4428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tacrine-6698	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.22436
GSE203308_7_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
697	CCLE Cell Line Gene Expression Profiles	1.0	2.655
Pectoral fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.729
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.914205
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.888601
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ficolin-1-rich granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.683
BRD-K44141416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6812
Signal Transduction	Reactome Pathways 2024	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary motor area, Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56422
CP-320650-01-3905	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35229
cell morphogenesis involved in differentiation	GO Biological Process Annotations 2015	1.0	null
abnormal bone structure	GWASdb SNP-Phenotype Associations	1.0	0.510289
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Alveolar cell type II	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.676
Prestwick-1083-2976	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mycolate outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
IDI2	Pathway Commons Protein-Protein Interactions	1.0	null
MTERF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33149
Endochondral bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.529
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21956
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.982455
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHPG-0626-SM-3NMBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Chondrogenic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.386
Lip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
superficial stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05039
methotrexate-5000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93806272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78514
COL1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97412
ING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61736
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
INPP4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35425
GSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09111
BRD-K24124047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56011
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.74135
BRD-K04336022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81391
SOST-related sclerosing bone dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.05
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-0.949002
synovium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.279307
bezafibrate-4999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PRRT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13279
BRD-K07276273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70369
Physico chemical features and toxicity associated pathways	WikiPathways Pathways 2024	1.0	null
BRD-K87754766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80055
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.406
BRD-K47349869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05507
METTL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23139
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.920796
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87901
PMC4747358__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K25942808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16761
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Secretory dimeric IgA immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.99
SDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36863
TRIB3	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZQ-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24125966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98768
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16463
BRD-K87929769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5019
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
ENTPD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46569
GNG13	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-374b	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
odontoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.212586
BMI1-19503595-MEFC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PORCN	Pathway Commons Protein-Protein Interactions	1.0	null
SNU466	CCLE Cell Line Gene CNV Profiles	1.0	1.84978
DM3	CCLE Cell Line Gene Expression Profiles	1.0	1.84719
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r3 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10623
MSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36213
regulation of stress-activated protein kinase signaling cascade	GO Biological Process Annotations 2015	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906085
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K64730761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77888
Anterior hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08538
USF	MotifMap Predicted Transcription Factor Targets	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05612
hsa-miR-369-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
NCOA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8971
zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068177
19192944-table2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-TMMY-1926-SM-4DXUU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31024
BRD-K03935681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00109
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72477
Perturb_3789_KD_PSDM13_SRP042158	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Fetal Death	CTD Gene-Disease Associations	1.0	1.49356
VPS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98919
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Hindgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.179
HUTU80	CCLE Cell Line Gene Expression Profiles	1.0	1.52488
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18577
ZBTB17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6812
BRD-K89891928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07586
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276495
breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.082717
Uterine Carcinosarcoma_UCS_TCGA-NF-A4WX-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Reproductive organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
TNPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71068
GSE193351_4_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Melanogenesis	KEGG Pathways 2026	1.0	null
A-CA-04-2009(H1N1)_Day1_22532695_GSE36328	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.19518
GSE111035,GSE111040_8_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
regulation of phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE193351_1_v_3_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128844_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TF1	DepMap CRISPR Gene Dependency	1.0	2.93411
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.16797
BRD-A95970093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59029
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890218
vermiform appendix	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.409351
RUNX2-24764292-MC3T3-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
damage	GeneRIF Biological Term Annotations	1.0	null
MRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67887
ZNF174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40686
HOXB4_02_64	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.0
BRD-K66030669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19239
GTEx Esophagus 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	6.18869
Perturb_3393_KO_Cblb_SRP347245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.81728
Breast cancer	KEGG Pathways 2026	1.0	null
BRD-K39237487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35924
STAT5A_02_182	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.16993
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ascidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.805
ethionamide-4418	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
citalopram-3820	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4711-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
CDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39605
MFSD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93614
nialamide-3790	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
septodiagonal transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33886
Anterior hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04781
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2019
cerebellar vermis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.14001
Tenocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.033
PMC8898985-NIHMS1734801-supplement-1734801_Supp_table.xlsx-5B-Hypothalamic_Vglut2_Cnr1_Ninl_Rfx5_Zfp346_Neuron_ZNF346	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thioridazine-4454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell morphogenesis	GO Biological Process Annotations 2015	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
A-VN-1203-2004(H5N1)_Day7-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.01418
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.855891
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36035
PRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89043
TRAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22333
r7 portion of ambiguous motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21234
Osteomalacia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
GTEX-OOBK-0226-SM-2YUMF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-OXRO-0126-SM-2YUN4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904519
BRD-K36149853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64543
MALME3M	CCLE Cell Line Gene CNV Profiles	1.0	1.64268
GTEX-PLZ5-2026-SM-2S1O4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59584
hair follicle outer root sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.382884
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14078
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
leukocyte disease	GWASdb SNP-Disease Associations	1.0	0.29046
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849532
MICOS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90259
irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.080216
BRD-K30615964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92593
SPRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15808
GATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62177
SNU626	CCLE Cell Line Gene CNV Profiles	1.0	1.34109
Parathyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.149
ZNF285	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49043
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
ATF7IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81306
Brain Lower Grade Glioma_LGG_TCGA-DU-6402-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29209
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25188
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK8_knockdown_163_GSE38061	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.590437
GTEX-RWS6-2026-SM-2XCB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80201
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
BRD-K50127933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42733
OVCAR8	CCLE Cell Line Gene CNV Profiles	-1.0	-2.02763
GTEX-PWCY-0426-SM-48TCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6314
intermediate stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09421
RUVBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48033
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945468
Wnt signaling and pluripotency	WikiPathways Pathways 2024	1.0	null
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826987
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
BTBD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41735
Osteochondrodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.079
lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.758193
ethisterone-3864	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HT144	DepMap CRISPR Gene Dependency	1.0	2.61733
BRD-K06459664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96843
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64917
CCSAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75212
SKMEL31	CCLE Cell Line Gene CNV Profiles	1.0	1.4466
valproic acid-1155	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K84990603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4933
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.934691
STL304557	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
pramocaine-3894	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
wnt9a	GeneRIF Biological Term Annotations	1.0	null
tooth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067783
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vitelline membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
metamizole sodium-3929	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fibula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.236
Alzheimer disease-presenilin pathway	PANTHER Pathways	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.795
XPOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86531
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF440	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33234
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.32906
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27815
NCKIPSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64626
Perturb_6717_KO_DNMT1a/DNMT3b_SRP098688	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Pronephric tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
Antler	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
DCA_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SALL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97003
optic cup	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.520829
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9285
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.9145
BRD-K67484361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55334
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.053409
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
ASPRV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52734
oxidative stress-induced premature senescence	GO Biological Process Annotations 2015	1.0	null
GSE89018_12_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A72E-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IgA immunoglobulin complex, circulating	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.676
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98685
BRD-K61335814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41253
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.693719
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
EMX2_Deficiency_GDS3173_607_mouse_Embryonic urogenital epithelium - day 10.5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K13113551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63706
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7226
furazolidone-4178	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBED-1926-SM-47JYP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.57159
quinpirole-456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-1272	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Prestwick-1080-3796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE143955_1_v_2_ripk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Synovium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.638
ACAD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69093
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33261
ATCAY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25933
HMGXB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66907
GTEX-QLQ7-1926-SM-2S1R6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
dihydroergotamine-6840	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97218
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847697
leukemia	GeneRIF Biological Term Annotations	1.0	null
hydroquinine-2767	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FLYWCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67985
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.978731
GSE243491_1_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Basal cell carcinoma	KEGG Pathways 2026	1.0	null
zona incerta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.83784
regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANKRD16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85327
placenta_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.15115
medial geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05719
ChIP_SUZ12_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07917
EGR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98549
LIPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0767
skin	GTEx Tissue Gene Expression Profiles	1.0	1.02659
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K37680172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10515
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.15102
Agranular insular area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20531
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.2944
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
PMC12909843-41467_2026_68388_MOESM4_ESM.xlsx-fig3g-up-regulated_gene_expression_in_OTX2-KO_8CLCs_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
ERRFI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33874
NCOR2	Pathway Commons Protein-Protein Interactions	1.0	null
ChIP_RNF2_22325148	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-S3XE-1626-SM-3K2AJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Osteoblast differentiation and related diseases	WikiPathways Pathways 2024	1.0	null
BRD-K29379469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61628
TCEAL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51415
Perturb_10375_KO_Fdft1_SRP285919	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.23479
ARAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14169
BRD-K30264389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47928
PMC4293272__F2	PFOCR Pathway Figure Associations 2024	1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5889
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Metabolic disorders of biological oxidation enzymes	Reactome Pathways 2014	1.0	null
EED	ChEA Transcription Factor Targets	1.0	null
UBE2Z	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8093
SNAI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35967
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05564
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.498248
BRD-K91516693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0764
Dental follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.997
felbinac-3398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TNP-470	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.68
UBXN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06424
intermediate stratum of m2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22253
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6382
negative regulation of cell death	GO Biological Process Annotations 2015	1.0	null
HTRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64328
Weight Loss	CTD Gene-Disease Associations	1.0	1.03046
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Class B/2 (Secretin family receptors)	Reactome Pathways 2014	1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mesoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.831129
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAGEH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94386
GTEX-VJWN-0126-SM-3GIK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24698
OST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42239
piromidic acid-4398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Uterine epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.902
CRCGN015_MCF10A_48H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01198
hek293	HPA Cell Line Gene Expression Profiles	1.0	1.82162
trimethylcolchicinic acid-2802	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OOBK-0126-SM-2YUND	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4644
CACNA1A	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59388
UBR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45081
rat	GeneRIF Biological Term Annotations	1.0	null
PRKAG3_KO_GSE4063_389_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NCI-SNU-5	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
BRD-K69294714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40913
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.70178
SUZ12-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
RFNG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37717
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16463
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96605
20166207-Table6	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XPVG-2626-SM-4B669	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31085
BRD-K32214429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67646
OSBPL1A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUJ4-1626-SM-4BONV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21091
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.275444
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
mephenytoin-5801	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77214780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75124
PMC10934115__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC11307286-ao4c01308_si_001.pdf-15-NFAT5_NFAT5	Rummagene Transcription Factor Associations 2026	1.0	null
KLM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45264
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906566
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59535
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80672
Pathways in cancer	KEGG Pathways 2026	1.0	null
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HEYA8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42469
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.294007
NCIH1373	DepMap CRISPR Gene Dependency	1.0	3.67978
A10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
Prestwick-981-3125	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.539
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858648
hsa-miR-3123	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
developmental process	GO Biological Process Annotations 2015	1.0	null
paracentral lobule, posterior part, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04246
KLLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70632
GTEX-TSE9-2526-SM-4DXUS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.43809
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36456
Wnt signaling in kidney disease	WikiPathways Pathways 2024	1.0	null
CTB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
mephentermine-3685	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OIZG-0726-SM-33HBL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33538
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Collagen network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.199
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.873056
positive regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.384
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.92707
SKOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41819
neck	GeneRIF Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72833997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14357
BRD-K91885806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00481
Orofacial cleft	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.557
Brachydactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
TBX3-20139965-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K52123140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87648
BRD-K15714104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1982
pro-b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.176182
MRPS30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50904
leukemia	GWASdb SNP-Disease Associations	1.0	0.565675
TMEM80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26956
BRD-K58270905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11862
Perturb_13750_KO_Bcl3_SRP179718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.4804
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.81821
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Np	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
B-lymphoblastic leukemia/lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
GTEX-NFK9-0226-SM-2HMKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14297
Flocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06517
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Femur	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.929
LPAR2	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Testolactone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.56
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1936
TFAP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39085
CRCGN014_HEPG2_3H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42905
HES4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66291
articular cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.56284
BRD-K54115231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.333
hair follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.3076
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.288514
GM133	BioGPS Cell Line Gene Expression Profiles	1.0	0.982142
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
Hair follicle bulge stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.28
PSS008	DepMap CRISPR Gene Dependency	1.0	3.51086
Perturb_7754_KO_LATS1/LATS2_SRP281854	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.13483
VPS35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21934
GTEX-PWO3-0926-SM-2I5EY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879579
BRD-K60898929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65985
Mesoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.165
epiandrosterone-2444	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anterior olfactory nucleus, external part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04669
DNAJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24412
MYH14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44772
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
negative regulation of cellular process	GO Biological Process Annotations 2023	1.0	null
Perturb_3781_KD_PSMD13_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ZBTB43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61628
15-delta prostaglandin J2-4455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intermediate stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18287
GSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20658
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	0.830554
Bone marrow stromal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
GTEX-RM2N-1426-SM-2TF4H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879956
buflomedil-3274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
beta-catenin destruction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.131
PMC8567035-CTM2-11-e578-s001.xlsx-transcription_misregulation-RUNX1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
leukemogenesis	GeneRIF Biological Term Annotations	1.0	null
posteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03853
BRD-K70844489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56926
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65203256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40389
Tenascin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.352
BRD-K11442063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1872
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35976
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02295
calcaneal	GeneRIF Biological Term Annotations	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
postulate	GeneRIF Biological Term Annotations	1.0	null
Chronic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
PF-01378883-00-6368	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DICER1_KO_GDS4504_584_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K64531971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44381
ampicillin-5408	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
L33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55983
BRD-K90879242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66334
mRNA_MYCN_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.32523
GTEX-WH7G-2326-SM-3NMBC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08258
lm(tk)	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.806
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.46178
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34591
subiculum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15925
LU99	CCLE Cell Line Gene CNV Profiles	-1.0	-2.52887
wnt16a	GeneRIF Biological Term Annotations	1.0	null
CER1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AMFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93165
GTEX-SUCS-0526-SM-4DM56	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
TTC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6364
GTEX-XUZC-1126-SM-4BOPZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880091
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K74482064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03422
KDM2A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54134201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00593
BRD-K87385385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20996
Rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
GTEX-X3Y1-2026-SM-3P5YM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982853
CRCGN017_MCF10A.WT.HP_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1081
IL17C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13817
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.88131
ADRA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17322
GCNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40509
mast cells	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.16171
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094213
BRD-K01850737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1669
frizzled binding	GO Molecular Function Annotations 2025	1.0	null
TLE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72953
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.503
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58865
Mavorixafor	DeepCoverMOA Drug Mechanisms of Action	1.0	0.55
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.30787
MAPK8IP3	Pathway Commons Protein-Protein Interactions	1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-TMMY-0226-SM-33HBA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29653
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.412011
Reelin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825786
SFT2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83546
Perturb_14596_OE_UQCRC1_SRP177975	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.38048
GSE112714_2_v_3_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4649-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.044922
missense	GeneRIF Biological Term Annotations	1.0	null
GTEX-P4PP-0126-SM-3LK69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04999
ENC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31087
MT-ATP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31003
GTEX-T2IS-0626-SM-32QP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Perturb_1161_KD_E2APBX1_SRP115954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.6021
Perturb_11620_KD_CTDSPL_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.96117
Ankle joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03581
BRD-K01367715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04724
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.05295
Bladder Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Synovial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.919
basal cell carcinoma	KEGG Pathways	1.0	null
GTEx Lung 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	4.3409
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.76
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.799
496100425_TCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.04356
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8062
Kidney Chromophobe_KICH_TCGA-KO-8410-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35701
stress-induced premature senescence	GO Biological Process Annotations 2015	1.0	null
Perturb_11551_OE_SIRT6_SRP394380	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.48726
AMBRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45174
supported	GeneRIF Biological Term Annotations	1.0	null
lymphnode_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.856898
SW579	DepMap CRISPR Gene Dependency	1.0	3.83958
HOXC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28692
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
BRD-K90741031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46864
GSE185635_0_v_1_ncor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SC-19220-7090	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K68512873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72093
RBM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43605
neostigmine bromide-2432	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JARID2	ChEA Transcription Factor Targets	1.0	null
Apocrine sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.019
thickness	GeneRIF Biological Term Annotations	1.0	null
ferulic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00125
bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.811411
GSE252857_2_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Tarsal bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.556
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49868
KMRC20	CCLE Cell Line Gene CNV Profiles	1.0	1.59756
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052465
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CSTB_KO_GDS5091_23_mouse_cerebellar granule	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85855
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
chlorcyclizine-3893	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K24387453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57483
BRD-K11573765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78703
Signaling pathways regulating pluripotency of stem cells	KEGG Pathways 2026	1.0	null
skin	HPA Tissue Protein Expression Profiles	-1.0	-0.835922
intermediate stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20004
BRD-K97362312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55738
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933768
Lung squamous cell carcinoma_LUSC_TCGA-22-5492-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-486-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
EGFR_druginhibition_83_GSE27640	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.6847
lysergol-1325	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K28433349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.80161
GLG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00928
SLC1A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3349
BRD-K36460068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29565
Flocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06005
GTEX-S7SE-0126-SM-2XCD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52034
Signal Transduction	Reactome Pathways 2014	1.0	null
Osteogenesis imperfecta	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.117
TBX3-20139965-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.77263
hsa-miR-2276	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
STMN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08196
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
IPO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82304
astrocytes	BioGPS Cell Line Gene Expression Profiles	1.0	1.10412
H3K27me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GLI3T_Lipofectamine transfection_GDS4346_616_human_Panc-1 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NR0B1	ChEA Transcription Factor Targets	1.0	null
SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.86054
edrophonium chloride-5001	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
coffin-siris syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.11477
SLC25A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12559
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084882
Medial geniculate complex, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0549
positive regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
ASXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23051
Lymphoblastic lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
t55-gastrocnemius_male_8w	MoTrPAC Rat Endurance Exercise Training	-1.0	-8.05563
PMC11740738-peerj-13-18818-s002.csv--TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Idiopathic juvenile osteoporosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.692
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.056
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.056
promotes	GeneRIF Biological Term Annotations	1.0	null
BRD-K73075421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36625
GTEX-WZTO-0426-SM-3NM99	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904884
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.894023
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WYBS-0626-SM-3NMAS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25362
KRAS.600_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SULT1C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02975
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.89669
SNU5	CCLE Cell Line Gene CNV Profiles	1.0	2.59783
KLRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9212
Acute Myeloid Leukemia_LAML_TCGA-AB-2973-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
B-cell acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
sulfamerazine-3616	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pro-B-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.405
rotenone-5915	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Synovitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
IQSEC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63768
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	5.22111
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48698
ZFP57-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hFOB 1.19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
ICC3	DepMap CRISPR Gene Dependency	1.0	2.46681
GSE240468_3_v_6_nfyc_human	RummaGEO Gene Perturbation Signatures	1.0	null
SDR39U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52272
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50627
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.358919
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
SOHLH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51278
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XUZC-0426-SM-4BOPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Feather rachis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.936136
disease	GWASdb SNP-Disease Associations	1.0	0.134382
KLHL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87587
limb bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.218186
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K91652715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01995
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1627
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K28811650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11519
GTEX-VUSG-2526-SM-4KL1V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4858
Brain Lower Grade Glioma_LGG_TCGA-FG-A70Z-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Leiomyoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.039
BRD-K97733472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37236
Metatarsal bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
Kidney Failure, Chronic	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K01699883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35794
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
leiomyoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.328834
VMCUB1	CCLE Cell Line Gene Expression Profiles	1.0	1.47454
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4V-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extracellular region	GO Cellular Component Annotations 2015	1.0	null
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
survivin	GeneRIF Biological Term Annotations	1.0	null
Ceritinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.52
BRD-K77965546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21149
HCT116	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
TPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26852
Lupus Erythematosus	DisGeNET Gene-Disease Associations	1.0	null
BRD-K89397494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51225
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.1996
GSE203308_14_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hip joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.991
Enamel organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.903
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.176194
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.105481
496100403_TCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11325
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.905827
Polymeric IgA immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.697
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CH5132799	DeepCoverMOA Drug Mechanisms of Action	1.0	1.23
BRD-K14823121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95548
TM9SF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84777
BRD-K11700411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56089
GTEX-RU72-0926-SM-2TF6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41197
A-VN-1203-2004(H5N1)_Day2-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.1153
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2952
decidual cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.289582
UBQLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40729
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Chronic lymphocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.466
horizontal nucleus of the diagonal band, transitional part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48202
PMC9453844__F6	PFOCR Pathway Figure Associations 2024	1.0	null
CLDN18_KO_GDS4961_28_mouse_whole lung tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.09588
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93545
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.24677
leiomyoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.584422
GSE89018_10_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4293272__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Prestwick-972-3132	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.152857
BRD-K26582498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13331
SEPTIN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37088
GTEX-XUJ4-1826-SM-4BOOU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918702
blastula	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0721
PCNX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41109
patterns	GeneRIF Biological Term Annotations	1.0	null
joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.791877
AGTRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09838
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01203
hedgehog signaling pathway	KEGG Pathways	1.0	null
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.839874
GTEX-RN64-0126-SM-2TC68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47648
paroxetine-3904	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6888566__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Endometrial gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.999
hsa-miR-499-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K01329192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18033
BRD-K34929471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11921
AMER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18516
BRD-K58445641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5619
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30687
fractures	GeneRIF Biological Term Annotations	1.0	null
NCIH1915	CCLE Cell Line Gene Expression Profiles	1.0	1.3559
RCOR1	ENCODE Transcription Factor Targets	1.0	null
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38899
BRD-K30312557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05849
regulation of phosphatidylinositol 3-kinase signaling	GO Biological Process Annotations 2023	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5530-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944793
GNG5	Pathway Commons Protein-Protein Interactions	1.0	null
MAPK1_knockdown_112_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.69193
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
skin_5f	HPA Tissue Sample Gene Expression Profiles	1.0	2.00517
Turofexorate	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888711
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K86192746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2141
ZNF629	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46768
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WYVS-1626-SM-3NM9R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41597
CTNNB1	ChEA Transcription Factor Targets	1.0	null
ATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67878
TET1-21451524-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.95209
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6762
lateral superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23433
BRD-K63163033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75945
GSE264621_1_v_6_secretin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66045
hsa-miR-137	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Anterior olfactory nucleus, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49896
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833642
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of forebrain morphology	GWASdb SNP-Phenotype Associations	1.0	0.425394
BRD-K96120749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54239
downstream	GeneRIF Biological Term Annotations	1.0	null
HDHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1754
MGAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03324
IA-LM	GDSC Cell Line Gene Expression Profiles	-1.0	-1.8084
NCIH322	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93858
CST6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85033
Acute Myeloid Leukemia_LAML_TCGA-AB-2911-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.17912
GARRE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81802
SMC1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.608
ANKMY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75607
intermediate stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02983
ESRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62265
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.65393
GTEX-WFG8-0426-SM-3GILD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
breast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060231
bone resorption disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.90321
hsa-miR-3200-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Collagen trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.585
TSHZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83656
Breast adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
PPP1CA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97212
Intergeniculate leaflet of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16394
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
genomic	GeneRIF Biological Term Annotations	1.0	null
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.784
GTEX-T6MO-1926-SM-32QOJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
SLC22A31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80896
ZNF492	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43989
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
DPY19L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22615
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Decidual cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.131
pentamidine-4396	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZBTB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48334
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08757
decreased femoral compact bone area	MGI Mouse Phenotype Associations 2023	1.0	null
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
Hinge joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Frontonasal dysplasia 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
hsa-miR-146b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PUF60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20379
TBK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28902
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TMED5	Pathway Commons Protein-Protein Interactions	1.0	null
flumequine-2276	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895627
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.21888
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053722
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BNIP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42733
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876982
GNG8	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMK1-0126-SM-4B65F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987415
PMC8457865__F8	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-RU1J-0826-SM-46MUU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
NUDT15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91859
CRCGN016_MCF10A.TP53.M_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1527
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HN-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34737616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06894
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K09594570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09045
polydactyly	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.408666
external part of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22836
Wnt Signaling Pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
Prostate gland stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
Ameloblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083141
hsa-miR-539	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
PTBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19911
ZDHHC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94004
Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mepenzolate bromide-2169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hexylcaine-2708	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARID1A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135514_8_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
periventricular mantle of isBM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02479
GTEX-XBED-2226-SM-47JYQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29279
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.506672
leiomyoma	GeneRIF Biological Term Annotations	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
LAN2	DepMap CRISPR Gene Dependency	1.0	10.1698
effects	GeneRIF Biological Term Annotations	1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.67009
hsa-miR-4802-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
DHCR24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97267
UBR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78125
POLR2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90446
Gracile nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34001
myosmine-4759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VPS26B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94771
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.870914
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847697
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-BHLHE40_BHLHE40	Rummagene Transcription Factor Associations 2026	1.0	null
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.043618
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
HMGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98031
positive regulation of mapk cascade	GO Biological Process Annotations 2015	1.0	null
BRD-K43473008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43758
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CHUK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93528
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K02321382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10966
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.357467
TTLL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05207
Leukopenia	CTD Gene-Disease Associations	1.0	1.11877
GTEX-T5JW-2026-SM-4DM63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
hippocampus (hippocampal formation)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.965089
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7398-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0726-SM-4B659	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6297
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CHMP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5238
solasodine-2170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SCN4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18705
GBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5771
NCCSTCK140	CCLE Cell Line Gene Expression Profiles	-1.0	-2.33884
receptor ligand activity	GO Molecular Function Annotations 2023	1.0	null
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARR3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05616059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04523
Eltrombopag	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
BRD-A57285050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.34114
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57552
BRD-K44212150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0286
METTL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96429
dermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.105675
BRD-K35826866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.40288
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
ATP11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56851
nefopam-2355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE174498,GSE174500_2_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.588031
GTEX-UPJH-0226-SM-3GADV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42764
Inner chondrogenic layer of perichondrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.386
BRD-K68731395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19205
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.474
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9227
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sotrastaurin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.97
Bone development disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.042
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.15055
response to stress	GO Biological Process Annotations 2015	1.0	null
SPCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7594
BRD-K94777797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39392
PMC11233907-mmc9.xlsx-S8-Table_S8_Colocalization_Analysis_for_MR_TWAS_PWAS_Hits_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0318
BRD-K70819166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.55927
CRCGN008_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8642
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2536
LHX8_Deficiency_GDS3254_600_mouse_Newborn ovaries	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040638
GTEX-RWSA-0126-SM-2XCBB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76973
BRD-K18094884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50906
abnormal bone strength	MPO Gene-Phenotype Associations	1.0	null
Acute Lymphocytic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
GTEX-OXRN-0126-SM-48TDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57921
hsa-miR-3662	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Cushing syndrome	KEGG Pathways 2026	1.0	null
Nucleus ambiguus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63638
Accessory olfactory bulb, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89182
MED12L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.4199
GATA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54697
GTEX-OHPK-0426-SM-3MJH3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863831
BRD-K13488816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48459
BRD-K95323755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02353
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.843
lymphoma	GWASdb SNP-Disease Associations	1.0	0.565675
JHH2	CCLE Cell Line Gene CNV Profiles	1.0	1.60828
Hypophosphatasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
BRD-K00223956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00261
ChIP_PHC1_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
RNF213	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95653
UFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82697
ARHGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79696
HBQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06344
cinchonidine-2772	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.249
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.35763
induced	GeneRIF Biological Term Annotations	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.857574
asthma	GWASdb SNP-Disease Associations	1.0	0.565675
SCA1_Knock-in_GDS1756_233_mouse_Forebrain tissue - 4 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K74600148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01624
PPIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11997
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16152
pre-b acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.41848
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
BRD-K05277255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60581
HPAC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
ZNF473	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64148
PF-00539758-00-6379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03713632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00307
FN3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64767
cefuroxime-5787	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
epithelial to mesenchymal transition	GO Biological Process Annotations 2015	1.0	null
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09632
GTEX-P4PQ-0126-SM-2S1NM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965534
BRD-K73994499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21303
PNU-0251126-3692	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Odontoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.172
Alzheimer disease	KEGG Pathways 2026	1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
OLIG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8165
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LIVF001-002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10601
GPAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39925
EIF2AK3	Pathway Commons Protein-Protein Interactions	1.0	null
Idiopathic scoliosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
TMEM8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.42162
CP67-MEL	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5398
BRD-K85559506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45451
stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.118464
GTEX-S4P3-1126-SM-4AD52	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14125
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.382131
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9031
BORCS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5594
OSBPL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5914
EKC/KEOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
Venous endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.695
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Osteoarthritis, Hip	HuGE Navigator Gene-Phenotype Associations	1.0	null
Perturb_6865_KO_CDK8/CDK19_SRP299261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
ZKSCAN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33004
triamcinolone-2241	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.1213
Feather bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.174
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.452
SNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47158
Femoral neck bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.4
indapamide-2322	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
osteoporosis-pseudoglioma syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.416
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
Osteosclerotic metaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
polymorphisms	GeneRIF Biological Term Annotations	1.0	null
BRD-K55814495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09906
Temporomandibular joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.344
GTEX-QEG4-0226-SM-2S1PY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30643
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.41313
WNT ligand biogenesis and trafficking	Reactome Pathways 2014	1.0	null
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4311	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974	Reactome Pathways 2014	1.0	null
CPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24063
GTEX-U4B1-1226-SM-4DXT7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
ZNF653	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31701
DDX53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27709
Nilotinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3607
regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
metixene-2451	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65780164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96942
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6572
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.924814
lymphopenia	GWASdb SNP-Disease Associations	1.0	0.565675
PPP2R3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93935
midodrine-1403	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ECE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62606
FCSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56702
Cranium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.977
HOXB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5948
KIRREL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95846
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29038
EGR1	ChEA Transcription Factor Targets	1.0	null
analyses	GeneRIF Biological Term Annotations	1.0	null
lateral septal nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2824
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21132
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Myotome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.043
Endometrial stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.786
IREB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10373
PMC3775648__F1	PFOCR Pathway Figure Associations 2023	1.0	null
MAP1S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64147
hindlimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.558856
Prestwick-691-2813	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.866935
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.933672
metrizamide-3255	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MKN45	GDSC Cell Line Gene Expression Profiles	1.0	1.73299
C6orf89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44367
MTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61078
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77886
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.642
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
clitoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.186763
extracellular region	LOCATE Predicted Protein Localization Annotations	1.0	null
Infratentorial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
ENDOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5815
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.106682
abnormality of the cerebral cortex	GWASdb SNP-Phenotype Associations	1.0	1.75294
calcaneal bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.884591
GTEX-U8XE-0326-SM-3DB8P	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25394
mRNA_ASCL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18984
hsa-miR-3065-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Prostate-fibroblast	Tabula Sapiens Gene-Cell Associations	1.0	-0.0359654
E2F3	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3149	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
X-linked dominant hypophosphatemic rickets	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
Perturb_3937_KO_DBC1_SRP371865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.72479
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25330450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14061
FGFR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4227
TRIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48413
RASA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33124
18337559-TableS1	GeneSigDB Published Gene Signatures	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.911
TADA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68617
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.924458
Nodular basal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
WI-38 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.924
positive regulation of intracellular signal transduction	GO Biological Process Annotations 2025	1.0	null
MLYCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70589
LAMC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21161
mephenesin-3675	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
rifampicin-2487	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
knee	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.497266
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
wnt16b	GeneRIF Biological Term Annotations	1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36078
GTEX-R55G-2426-SM-2TC5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.0537
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K38035271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15423
Notochord	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.421
Anterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01452
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
Hajdu-Cheney syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
GTEX-WRHK-1426-SM-3MJF9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977982
BRD-A86748098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16644
mood disorder	GWASdb SNP-Disease Associations	1.0	0.625509
BRD-K82681356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45238
Cementum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
SND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66238
BRD-K26435104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98801
central part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1504
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08861
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.622183
PPID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18477
mRNA_TCF7L2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954043
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85382
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
STK31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2712
GTEX-PLZ5-1826-SM-3NB22	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859413
prostate_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.10583
aztreonam-2118	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-5R-AA1D-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37821
LY-294002-4460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K13389917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63824
GTEX-S7SF-1626-SM-3K2AY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10722
Infralimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31545
BRD-K24453679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25625
BRD-K84514454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58467
mRNA_MYBL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
pancreas	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17582
GTEX-S3XE-1726-SM-3K2AM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03472
LNCaP-C4-2B4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
SLC25A45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92729
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.808
SOX2_Deficiency_GDS4853_319_human_AZ-521 gastric cancer (GC) cell line - 8 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042403
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19662
ENGASE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46454
MK2206	DeepCoverMOA Drug Mechanisms of Action	1.0	0.93
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
LSM14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95933
WDR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93115
BRD-K42511168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91986
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NOMO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81729
DDX31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36069
Embryonic stem cell pluripotency pathways	WikiPathways Pathways 2024	1.0	null
POM121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20954
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.49
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.294007
MED29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14503
GNB4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17718789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06974
DKMG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54817
dantrolene-3867	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE214596,GSE214598_1_v_4_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
MZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16316
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.559
Osteoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.063
BRD-K96154586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16127
HDLM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KIF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09943
RTL8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40874
clomifene-4994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ebselen-5778	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tendon sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.635
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7041
Perturb_6704_KD_LPA2_SRP057199	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.1887
positive regulation of phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
Eht	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
septopallidal core nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63516
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831138
cardiac epithelial to mesenchymal transition	GO Biological Process Annotations 2015	1.0	null
DICER1_KO_GDS4504_582_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
treatmentinduced	GeneRIF Biological Term Annotations	1.0	null
BRD-K95963125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3496
Arterial endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.843
lymphoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096589
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SIU8-0126-SM-2XCDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76022
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.850837
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01667
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98379
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
BRD-K66735566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0563
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64347
PPME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61229
RAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64977
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16748
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.966282
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.379
ASF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24605
Hypertension	CTD Gene-Disease Associations	1.0	1.03493
BRD-K49698948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03799
Chondrosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0896
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE112174_5_v_7_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
GRHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2013
19658189-TableS3	GeneSigDB Published Gene Signatures	1.0	null
PAC-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
Dental pulp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.35
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7974
RING1B-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SENP7	Pathway Commons Protein-Protein Interactions	1.0	null
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98379
GTEX-QESD-1426-SM-2S1R9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88314
Embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.625
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
FASTKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64273
lens fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.385143
GNB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A55020151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05596
BRD-K96637326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08678
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33243
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.69079
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.6852
CBX2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C1QTNF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35596
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6917
Hepatocellular carcinoma	KEGG Pathways 2026	1.0	null
fulvestrant-4429	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Wnt-16 protein	InterPro Predicted Protein Domain Annotations	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
SELENOK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71166
amprolium-1898	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-NFK9-0426-SM-2YUNK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Perturb_6791_KD_CDK12_SRP042402	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.91494
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9959
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-U4B1-0226-SM-4DXU8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-XQ8I-0226-SM-4BOPM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875323
GTEX-QV44-1926-SM-2S1RF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18086
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TE-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HOXB6_HOXB6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPIC-0226-SM-3GADO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
MAK16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52089
BRD-K11566982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03393
ADCY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81167
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36337
hsa-miR-1278	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
PMC7888617__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PDPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70734
Prostate	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.826147
19168792-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Coffin-Siris Syndrome	DisGeNET Gene-Disease Associations	1.0	null
BRD-K34506374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50115
ETFBKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87905
Human - Fetal Development - L2 - Stomach-Lymphatic endothelial cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
layer 3 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19647
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.503
Feather	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.207
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30463
OVCAR4	CCLE Cell Line Gene CNV Profiles	1.0	1.63919
Wnt signaling pathway	PANTHER Pathways	1.0	null
CSTB_KO_GSE47516_132_mouse_granule neurons	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PIAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38474
ERBB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2685
BRD-K31187110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03555
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6238
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
valproic acid_homo sapiens_gpl570_gse14973	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36084688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96742
BRD-K31852848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12493
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Catenin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.938
ARHGAP11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50784
BABAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96271
ARID3A_02_193	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.64386
NEUROG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44755
Sebocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
hsa-miR-4713-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.90094
MTMR6	Pathway Commons Protein-Protein Interactions	1.0	null
SYK_KD_GDS3609_440_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
Dentin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.258
Bone matrix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.949
BRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23497
D283MED	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87894
Perturb_6848_KD_KIF26B_SRP261132	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.42016
gigantocellular group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.834255
ARNT2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K82683018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60256
SERPINB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98646
alzheimer's disease	GWASdb SNP-Disease Associations	1.0	1.83661
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.4531
etanidazole-2510	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845703
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6516-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
ARHGEF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05506
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13637593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43695
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P44H-0226-SM-2XCEU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42535
estradiol_homo sapiens_gpl571_gds4052	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MO-0526-SM-4DM6R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Bone mineral density (paediatric, skull)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.15229
BRD-K24292260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73939
GTEX-TML8-1126-SM-4DXSS	GTEx Tissue Sample Gene Expression Profiles	1.0	3.7903
PHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51546
Wnt protein, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
dorsal peduncular cortex, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03278
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.692
pyridoxine-2751	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X4XX-0126-SM-3NMC2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04576
oxetacaine-1484	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pre-B acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
LPAR4	Pathway Commons Protein-Protein Interactions	1.0	null
Ocellus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
GTEX-X8HC-0126-SM-4E3JW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975454
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
HDAC5	Pathway Commons Protein-Protein Interactions	1.0	null
SNU1196	DepMap CRISPR Gene Dependency	1.0	2.21194
BRD-K92291448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20672
BRD-K27147269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3857
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.23514
SARM_KO_GDS4842_412_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NECAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11286
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A13210451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01019
GSE210951_1_v_0_islr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBE2O	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85803
regulation of signaling	GO Biological Process Annotations 2015	1.0	null
GTEX-WI4N-1026-SM-3LK7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15797
peak	GeneRIF Biological Term Annotations	1.0	null
TET1-21451524-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
RELA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51309
hsa-miR-374a	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.05304
namalwa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.589635
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7364-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9882
thiamazole-3898	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal skeleton morphology	MPO Gene-Phenotype Associations	1.0	null
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
CCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16061
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32616
EMSY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53081
L3MBTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85974
abnormality of bone mineral density	GWASdb SNP-Phenotype Associations	1.0	2.57156
PMC2788255__F6	PFOCR Pathway Figure Associations 2023	1.0	null
skin_5e	HPA Tissue Sample Gene Expression Profiles	1.0	2.521
PMC12311176-41408_2025_1333_MOESM2_ESM.xlsx-Table_S10-Table_S10_SOX11_SMARCA4-direct_target_genes_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
NOTCH1_Deficiency_GDS2848_635_mouse_Hair follicles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7862-01A-21R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3470785-NIHMS377161-supplement-3.pdf-101-ZBTB5_ZBTB5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61438422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08219
Bruck syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PLD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80943
GTEX-WHSE-0126-SM-3NMBT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96563
Perturb_1247_KD_PBX1_ERP116472	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.97029
PHA-00767505E-6596	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QCQG-1726-SM-3GIJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0752
REXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70702
JARID2-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
RBM41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50207
PIGG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98229
BRD-K29366596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76613
BRD-K28108927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85676
BRD-K16551475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21975
GTEX-W5X1-2526-SM-3GILC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6402
FOXD4L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47183
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6085667__F5	PFOCR Pathway Figure Associations 2023	1.0	null
Nucleus pulposus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03937692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57731
Brain Lower Grade Glioma_LGG_TCGA-CS-5395-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K21443215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65626
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Wnt signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.292
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84606053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8406
CRCGN014_HEPG2_3H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3486
Epidermal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.766
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40219
BRD-K32019201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19205
connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.085152
Apocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
PHC1	ChEA Transcription Factor Targets	1.0	null
fluoxetine-2453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TTC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.50221
immune system disease	GWASdb SNP-Disease Associations	1.0	0.048113
Stomodeum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.112
BRD-K83122599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46304
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
AR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41344
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875847
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23146
wnt16	GeneRIF Biological Term Annotations	1.0	null
senescence	GeneRIF Biological Term Annotations	1.0	null
cyproterone-4470	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Alzheimer 39 s disease and miRNA effects	WikiPathways Pathways 2024	1.0	null
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17816
RNF44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71965
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.892418
AJM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83821
RIOK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75027
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.046
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9356
CCDC88B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52977
SAFB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86909
BRD-K06428422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77822
CEBPZOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45379
RAPGEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77738
TMEM47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14844
ALKBH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00435
lateral posterior nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4459
vestibular nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08704
fulvestrant-5964	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH1339	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43664
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	177.182
TBX3-20139965-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
BRD-K61053165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04194
HIPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32087
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46228
r4 part of medial paralemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47742
estradiol-5905	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22420708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23703
Perturb_17814_KO_Pdgfra_SRP051537	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.817
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
granular layer of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07898
Heel bone mineral density variance	GWAS Catalog SNP-Phenotype Associations 2025	1.0	4.4699
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.387
TMEM248	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23288
isosorbide-4742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-3653	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
COA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0397
PELI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58757
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
LSM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55621
Trabecula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.167
Corona	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.878
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anorexia	CTD Gene-Disease Associations	1.0	1.08407
individuals	GeneRIF Biological Term Annotations	1.0	null
Perturb_5506_KO_Nir_SRP114858	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.93908
BRD-K01787291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07487
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893302
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
MARVELD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50759
SIRT4_KO_GDS4823_505_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
DDX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09039
BRD-K40011635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20173
GTEX-OHPK-2526-SM-3MJH9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02968
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARRB1	Pathway Commons Protein-Protein Interactions	1.0	null
not applicable_asthma_GSE43696_369_mouse_bronchial epithelial cell	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NCI-H1105	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AP5M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82543
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5938
KRAP_Deficiency_GDS3528_564_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_3967_KD_SF3B1_SRP126849	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.61549
KPT-330	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.47
forearm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.412011
Metaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.811
Sarcoma_SARC_TCGA-DX-A8BH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medication use (drugs affecting bone structure and mineralization)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.930103
RALA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1826
hsa-miR-524-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.119151
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909032
HMG20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91977
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21919
FDXACB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14479
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4273
CCND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56081
musculoskeletal system disease	GWASdb SNP-Disease Associations	1.0	0.422483
RIMOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30658
hsa-miR-548f	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
CEMIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81972
HMBS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53692
PMC12146336-Data_Sheet_1.pdf-12-ENSG00000196092_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
RASGRP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0951
HT144SKINFV2	DepMap CRISPR Gene Dependency	1.0	5.98965
TEX13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.02172
lymphocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.222938
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.79876
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3380-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRK-0226-SM-3NB2G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16001
GTEX-U4B1-0126-SM-4DXSN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.721988
negative regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
FSCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83757
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
solasodine-4305	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
WB-4101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41316
Bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.45
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838344
BRD-K45694673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51183
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32632
SCYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03484
GTEX-XUYS-0126-SM-47JWZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87549
hsa-miR-4424	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-A42246453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11081
GSE144484_2_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Wnt signaling pathway	GO Biological Process Annotations 2025	1.0	null
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.9669
GAS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77188
GTEX-P4QS-1826-SM-2S1NI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
positive regulation of stress-activated protein kinase signaling cascade	GO Biological Process Annotations 2015	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844668
heliotrine-2180	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K61660466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34373
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
PRPS1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39904
mRNA_ZSCAN4C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WXYG-2326-SM-4E3I6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955079
BRD-K91467861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14192
C19orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05957
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TY-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_ATF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ZNF24_01_353	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.2433
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K60507129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06322
ARL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55874
NU-DUL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-P4PP-1626-SM-2HMJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.24912
GSE197562_2_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CXCL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90531
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052565
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.99911
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AI-1726-SM-2S1PZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
Mullerian aplasia and hyperandrogenism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.384
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7101
Osteonecrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
apoptotic	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-145	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
myricetin-4170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HELZ2	Pathway Commons Protein-Protein Interactions	1.0	null
SOX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92922
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
SAG	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54272776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51041
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
496100335_PCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.57895
septopallidal transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64694
ZNF140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86392
EPHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65462
FBLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5269
BRD-K54265757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6916
CEP170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99639
laminin-8 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.56
PWWP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62611
GTEX-QVJO-1626-SM-2S1QW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40166
PARP12	Pathway Commons Protein-Protein Interactions	1.0	null
lorglumide-5619	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
frizzled binding	GO Molecular Function Annotations 2023	1.0	null
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	1.0	0.917511
mucous gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.348889
BRD-K97400656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08019
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.154907
Osteopenia	DisGeNET Gene-Disease Associations	1.0	null
chlorphenamine-2217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Thoracic spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
GOLGA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67032
Kidney Chromophobe_KICH_TCGA-KL-8325-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tooth germ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.282
19808871-TableS3	GeneSigDB Published Gene Signatures	1.0	null
BRD-K05975035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70733
JHOS2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69417
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28414977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11194
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.214
SCAND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29496
NERF2-26677805-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PSRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48982
BRD-K48540267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83422
Uterine Carcinosarcoma_UCS_TCGA-N8-A56S-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00819
AJUBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21144
BRD-K53544328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73902
urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043924
A427	GDSC Cell Line Gene Expression Profiles	1.0	1.55309
Interstitial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.017
GTF2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44551
tonsil	HPA Tissue Protein Expression Profiles	-1.0	-1.63275
RTKN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15073
keratinocyte differentiation	GO Biological Process Annotations 2023	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.503
Perturb_6864_KO_CDK8_SRP299261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-XXEK-1626-SM-4BRUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10105
leads	GeneRIF Biological Term Annotations	1.0	null
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9041
Perturb_6740_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.55873
INA6	DepMap CRISPR Gene Dependency	1.0	6.52647
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11247
GTEX-WI4N-2726-SM-3LK7Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29166
GTEX-XAJ8-1426-SM-47JYM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42988
superficial stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0549
B cell_Kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
p53	GeneRIF Biological Term Annotations	1.0	null
RAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64315
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE143692_0_v_1_trim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CACHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8053
SUZ12-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-PWOO-2426-SM-2S1OV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65613
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98685
BRD-K67146164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37782
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02537
endometrial gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07044
superficial stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45757
lumbar spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.357802
G protein-coupled receptor binding	GO Molecular Function Annotations 2023	1.0	null
Tooth	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.574
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.855832
GTEX-T6MO-1626-SM-32QOM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14449
BRD-K87939000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39734
alfadolone-3127	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POU3F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98808
MED23	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K55459289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14095
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83512
Perturb_5938_KD_NCOA7_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.21716
AFF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30355
positive regulation of phosphatidylinositol 3-kinase signaling	GO Biological Process Annotations 2023	1.0	null
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-R-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG7-0326-SM-3GILI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.355604
reticular formation of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06459
liminal part of the r10 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01132
BRD-K75657700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19334
biperiden-2460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.078199
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
N6-methyladenosine-6732	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-0.940471
core-binding factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.162
ARID5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77137
Total body bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
isometheptene-3145	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37994
Focal dermal hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
GTEX-RU72-1126-SM-2TF6H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
C5orf24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33459
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.833645
GNA14	Pathway Commons Protein-Protein Interactions	1.0	null
SIRT4_KO_GDS4823_30_mouse_hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
G-protein beta/gamma-subunit complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
bendroflumethiazide-3934	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WFG8-2526-SM-3GILR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
CORL23	DepMap CRISPR Gene Dependency	1.0	5.40917
JM1	CCLE Cell Line Gene Expression Profiles	1.0	1.36011
MMAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23527
CRCGN015_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9236
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17157530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10691
fluvastatin-3370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
neural plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217762
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45149
Subcutaneous tissue cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
hsa-miR-3129-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
Mantle cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
GTEX-RU1J-0426-SM-46MUK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
EXOSC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02704
Class B/2 (Secretin family receptors)	Reactome Pathways 2024	1.0	null
GTEX-XV7Q-1626-SM-4BRWC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10193
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE147366_3_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945468
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
INTS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92783
Bone marrow stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.09
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF316	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23651
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	141.552
ARPC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14833
BRD-K25540102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5324
TOX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64595
Primary motor area, Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11967
Parastrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58607
Bay 60-7550	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
YPEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10176
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B5-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2BC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.77795
egg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.307528
GTEX-P4PQ-1726-SM-3NB15	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888035
STRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03989
LMBRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87378
2-BFI	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14173
Chondrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.244
demonstrated	GeneRIF Biological Term Annotations	1.0	null
NOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7732
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047959
IMPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71657
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
GTEX-PWOO-2526-SM-2S1PG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
PMC4848140-NIHMS766301-supplement-9.xlsx-Role_of_NANOG_in_ESC_DE-Unnamed_13_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
Flocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0532
binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K90999585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.94883
BRD-K64222382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48721
cortical	GeneRIF Biological Term Annotations	1.0	null
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Periodontal ligament cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75173
JARID2-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86025
GTEX-QDVJ-1726-SM-2I5FX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962105
GTEX-U3ZH-2026-SM-3DB78	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3156
GTEX-S7SF-1426-SM-4AT5A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890353
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4179
MBLAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02101
MCAS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
suxibuzone-7163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05248348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09356
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69699
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
PRR13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66205
Endostyle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.173
ZNF382	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18596
layer I of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.892687
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
mammary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09282
positive regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
BRD-K78809123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43256
SMARCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07451
ZNHIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50359
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5886
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SFRP2	Pathway Commons Protein-Protein Interactions	1.0	null
UMUC16	DepMap CRISPR Gene Dependency	1.0	2.05191
Klippel-Feil syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45641
HCE-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OHPL-0008-SM-4E3I9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836814
Pleural mesothelioma	WikiPathways Pathways 2024	1.0	null
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ORAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40333
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
beta-catenin-TCF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.63
BRD-K92955882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01102
DNAJC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4598
corpus cavernosum penis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.453355
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870908
POLH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22551
extracellular space	GO Cellular Component Annotations 2015	1.0	null
BRD-K63364685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02602
SSTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54769
Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
psychotic disorder	GWASdb SNP-Disease Associations	1.0	0.498248
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77487
cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.572818
hsa-miR-4276	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69624
BRD-K99302735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40499
CL-40	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH1618	CCLE Cell Line Gene Expression Profiles	-1.0	-2.40021
fludrocortisone-3785	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.521223
Acute Myeloid Leukemia_LAML_TCGA-AB-2959-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF126	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11025
Signaling by WNT	Reactome Pathways 2024	1.0	null
TPSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79168
anatomical structure morphogenesis	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3180-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIRT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73302
DROSHA	Pathway Commons Protein-Protein Interactions	1.0	null
Brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
GTEX-PX3G-2526-SM-48TZV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0835
Ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.679
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.124
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
PRSS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20176
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.943229
epitiostanol-2922	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
LU-165	COSMIC Cell Line Gene Mutation Profiles	1.0	null
STAT1	JASPAR Predicted Transcription Factor Targets	1.0	null
UNC2881	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.05
regulation of apoptotic signaling pathway	GO Biological Process Annotations 2025	1.0	null
FAM219B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8895
GTEX-PLZ4-0226-SM-2S1NW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20317
GTEX-SNMC-1226-SM-2XCFP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65582
SIN3A	Pathway Commons Protein-Protein Interactions	1.0	null
cycloserine-3562	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Periodontal ligament	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.163
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944793
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053462
NR0B1-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.6016
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.858615
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
non-Hodgkin lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.755
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05211
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TYK2_knockdown_176_GSE44652	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.56006
hsa-miR-450b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.0035
BRD-K05950670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41192
TGFB_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
DNAH9	Pathway Commons Protein-Protein Interactions	1.0	null
CA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9781
estradiol-5960	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K89116076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67499
Kidney Chromophobe_KICH_TCGA-KN-8423-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cervical mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.358174
BRD-K37151525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20426
External ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.285
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5693
osteoarthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.760639
ANKRD28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31679
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10612
ANP32E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4171
GTEX-X5EB-1926-SM-4E3IW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56036
TUFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51092
conessine-4777	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SFRP4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETK-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC9942993-pone.0281645.s002.xlsx-non-AR_as_all_as_gained-ENSEMBL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
lateral part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34118
U251	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.864107
under	GeneRIF Biological Term Annotations	1.0	null
mantle zone of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10645
GTEX-QEG4-1126-SM-2S1P7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
canadine-2818	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
corpus cavernosum clitoridis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.470375
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBB_KO_GDS3906_491_mouse_Testis - 7 Days	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
key	GeneRIF Biological Term Annotations	1.0	null
GTEX-O5YT-0126-SM-48TBW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12321
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
PPP1R12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11342
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6314
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.921289
GGT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20646
GTEX-S4Q7-1126-SM-4AD6R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GTEX-R55E-0126-SM-2TC5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01387
hip	GeneRIF Biological Term Annotations	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
BRD-K47776393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1161
BRD-A44068497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63681
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06249
BRD-K44062658	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08373
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072408
PMC5960217__F4	PFOCR Pathway Figure Associations 2023	1.0	null
verteporfin-6817	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09602
GTEX-UPK5-2026-SM-4JBIM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906765
Mouselcells	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.164
BRD-K09919985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23583
GSE155031_6_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUP50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85684
TMEM168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.966
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.894023
RBBP7_02_74	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.53051
paraseptal subpallium	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23123
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C2CD4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32719
TGFBR1_activemutant_291_GSE14523	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.06029
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.864394
MXI1	ENCODE Transcription Factor Targets	1.0	null
BRD-K51196703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.79725
Skin stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.873
Nucleus ambiguus, dorsal division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32911
CL11	CCLE Cell Line Gene CNV Profiles	1.0	1.42498
WDFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65677
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93901
RNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68672
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51021
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.26794
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:I20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0868
GPM6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32434
H3255	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
positive regulation of stress-activated MAPK cascade	GO Biological Process Annotations 2023	1.0	null
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14465
GSE144347_1_v_0_crnkl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
e2apbx1positive	GeneRIF Biological Term Annotations	1.0	null
PMC9822887-41598_2022_27261_MOESM10_ESM.xlsx-HCT116_overlap_TCF7L2_CTNNB1_lo-Unnamed_1_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K54317642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58221
short insular gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.970183
intermediate stratum of p1Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06403
NCI-H2170	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
ADAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57669
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4724
CD68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95111
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CASP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86666
BRD-K63169405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00162
Perturb_13751_KO_Bcl3_SRP179718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.0709
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.815106
Mesonephric duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.837
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
GSE164874_5_v_1_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARRB2	Pathway Commons Protein-Protein Interactions	1.0	null
Bone resorption disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.222
NCIH1836	CCLE Cell Line Gene Expression Profiles	1.0	1.60221
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
island of Calleja major	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.90967
GMCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18852
forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.432991
RPP40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03051
GSE203308_14_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29W-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.179
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6417
Adrenocortical carcinoma_ACC_TCGA-OR-A5JX-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SIDT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25938
TMEM150A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40047
KURAMOCHI	CCLE Cell Line Gene Expression Profiles	-1.0	-2.77831
heart_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
ZMYND8	Pathway Commons Protein-Protein Interactions	1.0	null
capan2	HPA Cell Line Gene Expression Profiles	1.0	1.25372
hsa-miR-3124-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.796
GTEX-XUW1-0926-SM-4BONX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25221
TPPB	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.9
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K56357490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06449
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
GTEX-WYJK-0126-SM-3NMAB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882255
GTEX-U3ZM-1526-SM-3DB9D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06336
BRD-K84239940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04691
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-PWOO-2226-SM-2S1P1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44415
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16227
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29488
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03996
YY1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-429	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
estropipate-4472	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1836
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Major island of Calleja	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25745
BRD-K48129913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28106
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16406
Mesosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09834
MHHCALL3	CCLE Cell Line Gene Expression Profiles	1.0	1.97138
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19E-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paraventricular hypothalamic nucleus, descending division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6119
Tibia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.97
CELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29496
atrisk	GeneRIF Biological Term Annotations	1.0	null
BRD-K66700691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86123
Neural tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.314
Subpallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.672
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.14682
AOB, internal plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55069
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.056
zebrafish	GeneRIF Biological Term Annotations	1.0	null
IFT57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11949
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44322
Bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.969897
EOLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09615
Dorsal peduncular area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83494
Transcriptional misregulation in cancer	KEGG Pathways 2026	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K74817844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11928
Perturb_17433_KO_Il2ra_SRP167045	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.97229
FKBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57176
BRD-K37047627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04582
azapropazone-3143	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bone ultrasound measurement (velocity of sound)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.1
BRD-K32495578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89188
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
LY-294002-5965	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Renal medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
abnormality of skeletal morphology	GWASdb SNP-Phenotype Associations	1.0	0.33054
496100326_TCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.76699
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945468
BRD-K09248459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88923
cellular response to stress	GO Biological Process Annotations 2015	1.0	null
ENO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48077
lung_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
BRD-K13411423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99235
GTEX-QDVN-2026-SM-3GAEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32162
GSTA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3277
BRD-K84170953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65
Perturb_6866_KO_CDK8/CDK19_SRP299261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
arm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.170604
CLDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08426
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
wnt	GeneRIF Biological Term Annotations	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02705
BRD-K22418614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18827
SKNO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73931
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SYK_druginhibition_289_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.57543
snps	GeneRIF Biological Term Annotations	1.0	null
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
FRZB	Pathway Commons Protein-Protein Interactions	1.0	null
ERF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23278
ultrasound	GeneRIF Biological Term Annotations	1.0	null
PACS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40676
PMC7320752__F6	PFOCR Pathway Figure Associations 2023	1.0	null
KCTD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12814
layer 6 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39141
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.12249
positive regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
GTEX-S95S-1226-SM-4GICG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57001
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.057
SAOS-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.106
BRD-K53186055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10787
CYB5R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52294
decreased bone strength	MPO Gene-Phenotype Associations	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
all	GWASdb SNP-Phenotype Associations	1.0	0.077542
biotin-2428	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SE5C-1126-SM-4BRWZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01932
hFOB cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.531
prostate	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-383	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Ulna and radius bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.45229
COQ10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01904
Synostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.20501
TET1	ChEA Transcription Factor Targets	1.0	null
sequences	GeneRIF Biological Term Annotations	1.0	null
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.959057
WARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03859
effect	GeneRIF Biological Term Annotations	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
cinchonine-2133	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RM2N-0126-SM-48FDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
ALL-SIL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K86884344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67756
Mandible	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.264
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Human papillomavirus infection	KEGG Pathways 2026	1.0	null
Hair follicle inner root sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.228
positive regulation of stress-activated mapk cascade	GO Biological Process Annotations 2015	1.0	null
USP27X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62236
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3436-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C22orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.791
BRD-K38980456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69764
IER5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73072
BRD-K63800697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53113
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24503
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
verteporfin-6133	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE203308_7_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WEY5-2326-SM-3GIKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37338
strength	GeneRIF Biological Term Annotations	1.0	null
SLC17A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39139
C32	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
PRRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82262
superficial stratum of r4Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29328
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gandotinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.21
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80999
TDRD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69043
pyramidal cells of rostral CA4	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.931139
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
PDGFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10115
TMEM37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34728
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846885
parahippocampal gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02703
Fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.294
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.565675
FTC133	CCLE Cell Line Gene CNV Profiles	1.0	1.44561
BRD-K06310280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61769
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.728143
RALY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41812
mantle zone of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64623
GTEX-S3XE-0226-SM-4AD6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5277
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13193
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.277033
Myofibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.983
GTEX-T6MO-1226-SM-4DM5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18386
osteogenic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.470375
MTMR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62397
Sclerosteosis 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
bromopride-6037	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
levonorgestrel-3606	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RWS6-1726-SM-47JXP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38927
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
periventricular stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72679
enilconazole-3139	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell proliferation	GO Biological Process Annotations 2015	1.0	null
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091987
KLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97958
GTEX-U3ZH-1726-SM-3DB79	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
PMC8665548-12864_2021_8126_MOESM3_ESM.xlsx-M-TOR-mTOR_signaling_pathway_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_1027_KO_Ovgp1_SRP379795	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.3671
Nucleus ambiguus, ventral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84714
BRD-K35386584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.386
KDM2B-26808549-CHIP-SEQ-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.061888
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SPIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71769
periventricular stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03658
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
TP63	ChEA Transcription Factor Targets	1.0	null
Orbital area, lateral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53074
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2039
r5 part of the oral Sp5 subnucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04983
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04142
Spinal nucleus of the trigeminal, oral part, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03235
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46754
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.63275
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K34258763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1739
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20521
GSE203308_4_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
697	GDSC Cell Line Gene Expression Profiles	1.0	3.07673
SIRT4_KO_GDS4823_22_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_6727_KD_VPS4A/VPS4B_SRP187973	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.38879
WNK4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K37055068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57521
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r5 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14441
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.098766
BRD-K02078984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36018
pipenzolate bromide-2719	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QEG5-0226-SM-2I5GI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30299
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08773
CCT241533	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.62
Cleft palate	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.978782
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58673
BRD-K67626097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0474
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24918
BRD-K47275094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16929
life	GeneRIF Biological Term Annotations	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.683103
Enamel epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
GTEX-WXYG-2026-SM-4E3IY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04606
HS888T	CCLE Cell Line Gene Expression Profiles	1.0	1.41475
lncRNA in canonical Wnt signaling and colorectal cancer	WikiPathways Pathways 2024	1.0	null
Pediatric bone mineral content (radius)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
nordihydroguaiaretic acid-203	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC25A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67744
U-698-M	GDSC Cell Line Gene Expression Profiles	1.0	1.93007
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of JNK cascade	GO Biological Process Annotations 2025	1.0	null
NANOG	ChEA Transcription Factor Targets	1.0	null
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.936136
Bed nuclei of the stria terminalis, anterior division, ventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36062
Acute leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.557
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U8XE-0226-SM-4E3J3	GTEx Tissue Sample Gene Expression Profiles	1.0	3.4954
NCIH1703	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66773
well	GeneRIF Biological Term Annotations	1.0	null
Wnt signaling	WikiPathways Pathways 2024	1.0	null
doxylamine-1473	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K21997380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36173
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48148
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055427
PMC12122724-41467_2025_60028_MOESM6_ESM.xls-Supplementary_Table_4_Marker_g-Supplementary_Table_4_Marker_genes_of_six_TPIT_tumor_subtypes_TBX19	Rummagene Transcription Factor Associations 2026	1.0	null
naproxen-5457	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
METTL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3989
Cleft palate, cardiac defects, and intellectual disabillity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
HOXC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43858
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A101D	COSMIC Cell Line Gene CNV Profiles	1.0	2.44392
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.45238
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52508
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.944326
NCIH209	CCLE Cell Line Gene CNV Profiles	-1.0	-2.39166
synovial tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228764
MOSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08974
podophyllotoxin-6103	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_4484_OE_Msi2_SRP067535	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.57408
Brain Lower Grade Glioma_LGG_TCGA-HT-A5RA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1250_KD_TCF3_ERP116472	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.70469
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27334
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0121
r10 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.34051
abnormality of brain morphology	GWASdb SNP-Phenotype Associations	1.0	0.313623
TC205	DepMap CRISPR Gene Dependency	1.0	3.46733
adrenosterone-3107	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_8417_KO_Srsf1_SRP252896	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.96425
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
Cytoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.722
GTEX-RVPU-2226-SM-2XCAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15064
Chronic lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.303
PLEKHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61111
hydralazine-4746	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
TSPAN17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60282
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4684
PMC7788918-13058_2020_1379_MOESM2_ESM.xlsx-S9-S9_limma_voom_differentially_expressed_genes_ESR1_depleted_recurrences_vs_matched_primaries_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
Hemidesmosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.723