association dataset threshold value standardized value PMC9576445-IJG2022-9264555.nxml--Potential_targets_of_hsa-miR-15b-5p_AND_hsa-miR-16-5p_NOT_hsa-miR-184_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 6611_PPAT_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.577195 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.6452 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11242342-jcav15p4513s1.pdf-32-ZNF75A_ZNF75A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K91795767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33243 ursodeoxycholic acid-7243 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K07388954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20624 extracellular vesicle GO Cellular Component Annotations 2015 1.0 null inner SZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03582 BRD-K37971917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01685 BRD-K76539747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36377 posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.863347 macelignan LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51981 GSE66014_0_v_1_perhexiline_human RummaGEO Drug Perturbation Signatures -1.0 null fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069293 HPAFII Achilles Cell Line Gene Essentiality Profiles -1.0 -1.05265 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.252564 POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null renal cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.70927 A549_Temsirolimus_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141542 CCRT CEM BioGPS Cell Line Gene Expression Profiles -1.0 -2.8634 DDX1 Pathway Commons Protein-Protein Interactions 1.0 null GSE88819_11_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13062 microvillus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.42396 SAMHD1 Pathway Commons Protein-Protein Interactions 1.0 null CTPS1 Pathway Commons Protein-Protein Interactions 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81V-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K32949071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01574 BRD-K41410736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.11499 SIN3B-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-378e TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 HNF4A Pathway Commons Protein-Protein Interactions 1.0 null BRD-K70992537 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89042 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.51241 GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25636 BRD-K44416503 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42115 LY-294002-1227 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE229914_2_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K32214429 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76361 VDR ChEA Transcription Factor Targets 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVN-2226-SM-2S1PM GTEx Tissue Sample Gene Expression Profiles 1.0 0.96626 A549_SB431542_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0190655 Peripheral blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.679 urinary bladder HPA Tissue Protein Expression Profiles 1.0 0.703068 PA-TU-8988T Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.66503 Acute Kidney Injury CTD Gene-Disease Associations 1.0 1.11639 Prestwick-984-4948 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null tretinoin-1211 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GAPDH Pathway Commons Protein-Protein Interactions 1.0 null amidopyrine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82663 A361 BioGPS Cell Line Gene Expression Profiles 1.0 0.980297 A549_Filgotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150633 C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02117 COLO684 DepMap CRISPR Gene Dependency 1.0 6.25511 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.895315 H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.72705 HDAC1 ENCODE Transcription Factor Targets 1.0 null PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGACGTCA_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null plicamycin_homo sapiens_gpl570_gse25127 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null OXA1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07855 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.35602 GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K22701871 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27684 oa1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.881 T98G Achilles Cell Line Gene Essentiality Profiles 1.0 1.00735 mitochondrion LOCATE Curated Protein Localization Annotations 1.0 null mesoridazine-7017 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XUZC-2026-SM-4BRW9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905463 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Glycine reductase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.546 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN017_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53115 H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 5927_OGDH_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.647861 CORO1C Pathway Commons Protein-Protein Interactions 1.0 null GSE226249_2_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null Leukemia cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 BRD-K39267096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14341 496100522_PCx_dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.48878 BD-96-HO33_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.442408 prenylamine-5489 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AKT2_knockdown_44_GSE12291 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.11862 BRD-K45328741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12731 Lymphoblastoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.707 MDAMB453 CCLE Cell Line Gene Expression Profiles 1.0 1.3696 salivarygland_6c HPA Tissue Sample Gene Expression Profiles -1.0 -1.35402 nephronophthisis HPO Gene-Disease Associations 1.0 null outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.975633 naringenin-3278 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE145171_0_v_1_prox1_human RummaGEO Gene Perturbation Signatures -1.0 null CLTCL1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K43969492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.291 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PC-18-VX23_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.552312 PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGAYRTCA_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.270498 Intrinsic component of mitochondrial inner membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.006 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.63506 Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.279 GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08611 GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2965 CRCGN017_MCF10A.TP53.M_24H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.14569 intrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.605284 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K15273135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16544 spiperone-5777 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CAPZB Pathway Commons Protein-Protein Interactions 1.0 null BRD-K14813155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30534 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ranolazine_hTERT-HPNE Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00489714 GSE179531_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-623 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE164874_5_v_6_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12224833-12967_2025_6787_MOESM3_ESM.xlsx-DEGs_PDX1-GeneSymbol_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4327 TargetScan Predicted Conserved microRNA Targets 1.0 0.145356 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11634 Chronic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.127 BRD-K28375929 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79798 inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32178 Leukemia cell line TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 E2F1-26619117-HEPATOCYTES-MOUSE-LIVER ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE140997_4_v_7_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_WI38_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9924 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23669327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40363 BRD-K65733046 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25761 GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-520e TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GTEX-V1D1-2226-SM-3NMAX GTEx Tissue Sample Gene Expression Profiles 1.0 0.900354 EP300_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_SL-327_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.021686 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K04722226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15335 Respiratory chain complex IV COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.158 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14373 CCT6A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 2.26378 NR3C1 ENCODE Transcription Factor Targets 1.0 null CP-863187-7558 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ATF3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal muscle HPA Tissue Protein Expression Profiles -1.0 -1.52503 LS 180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.853207 TIAL1 Pathway Commons Protein-Protein Interactions 1.0 null outer CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.41305 bromopride-4278 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE131649_4_v_1_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPS14 Pathway Commons Protein-Protein Interactions 1.0 null capan2 HPA Cell Line Gene Expression Profiles -1.0 -1.08603 COLO849 CCLE Cell Line Gene CNV Profiles 1.0 1.5401 rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08422 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30407 fulvestrant-6997 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC10055287-media-6.xlsx-intersection_genes_up-FOXJ1_FOXJ1 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF207 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Tanespimycin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0138892 TGM3 Pathway Commons Protein-Protein Interactions 1.0 null Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.58 GTEX-U3ZN-2326-SM-3DB7W GTEx Tissue Sample Gene Expression Profiles 1.0 1.1094 NSUN5P2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68219 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE155695,GSE155696_1_v_0_acetaminophen_mouse RummaGEO Drug Perturbation Signatures 1.0 null Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.219 TFCP2L1 ChEA Transcription Factor Targets 1.0 null Retinitis pigmentosa DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 T47D DepMap CRISPR Gene Dependency 1.0 2.74123 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K12396271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75537 GSE48812_4_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-181d TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GSE219195_1_v_3_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null PB-18-HD85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.476395 MCF7_Roscovitine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168387 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.870987 BRD-K49584663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24965 MIB complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.798 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2935 CCLE Cell Line Gene CNV Profiles 1.0 1.41804 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Raltitrexed_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176407 Lung squamous cell carcinoma_LUSC_TCGA-60-2703-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.996632 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.0497 GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.5269 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73C-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNT34 Achilles Cell Line Gene Essentiality Profiles 1.0 1.47083 RBMXL2 Pathway Commons Protein-Protein Interactions 1.0 null emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.69895 hsa-miR-548y TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K52123140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17362 Nephronophthisis 12 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.826 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NMU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.169 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LEFTY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22502 COLO678 CCLE Cell Line Gene CNV Profiles -1.0 -2.22967 BRD-K76628294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52379 halcinonide-7379 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12429 GSE139992_1_v_0_mboat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null manganese ion binding GO Molecular Function Annotations 2023 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6513-01A-21R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5187 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146982_4_v_6_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null K562_Curcumin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0207793 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.743 heart disease GWASdb SNP-Disease Associations 1.0 0.800979 Plagl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.2374 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.50037 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27185 single-organism process GO Biological Process Annotations 2015 1.0 null BRD-K15427120 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07034 GSE103068_5_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null Orofaciodigital syndrome VII DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.516 BRD-K32723442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21365 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HT1197 DepMap CRISPR Gene Dependency 1.0 3.52676 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23876 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.831449 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R53T-0226-SM-48FEH GTEx Tissue Sample Gene Expression Profiles 1.0 1.33018 alprenolol-7141 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3126-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 gentamicin-5883 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31156 CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28837 iohexol-2461 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null piracetam-2861 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.84988 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930851 BRD-K75036062 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07738 GSE230263,GSE230265_5_v_1_runx1_human RummaGEO Gene Perturbation Signatures -1.0 null Hypothalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.493 PRDX2 Pathway Commons Protein-Protein Interactions 1.0 null A549_Fasudil_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0248481 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41466 TAF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SQRDL Pathway Commons Protein-Protein Interactions 1.0 null SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16808 Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null hsa-miR-520b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 FLI1 ChEA Transcription Factor Targets 1.0 null loxapine-5293 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A549_SGI-1776 free base_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146774 NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.980251 GSE205788_0_v_1_gfap_mouse RummaGEO Gene Perturbation Signatures 1.0 null cSARS Bat SRBD_30Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.9057 RPL36A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31074 GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48621 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Veliparib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.015188 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUZC-0626-SM-4BOPG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918407 naproxen-1706 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null exopeptidase activity GO Molecular Function Annotations 2015 1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE135514_8_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null PTBP1 Pathway Commons Protein-Protein Interactions 1.0 null HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.22274 H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A5-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K93023309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05948 CF-24-KQ98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.685522 GSE158320,GSE183351_0_v_3_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K14449601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.121 gastroesophageal junction TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83049611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3048 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Schizophrenia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.107 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06712 MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5441529-41537_2017_10_MOESM5_ESM.xlsx-Perturbagen_Comparison-71_common_elements_in_SZ-KD-Therap_and_RA-KD-Causative_AR Rummagene Transcription Factor Associations 2026 1.0 null Perturb_1006_KO_Bcl9l/Bcl9_SRP045828 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.75329 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K13515483 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81357 verapamil-6287 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A549_Barasertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150401 JHH7 CCLE Cell Line Gene CNV Profiles 1.0 1.39982 BRD-K89668690 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04749 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824684 Npas4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.0898 Kidney disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.664 alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 5230742-862 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49658 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.258 GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.8961 hsa-miR-548c-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PSDG-0726-SM-2I5FN GTEx Tissue Sample Gene Expression Profiles 1.0 1.20551 Perturb_1783_KO_Msi2_SRP201799 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.23561 ATF1 ENCODE Transcription Factor Targets 1.0 null ATF3 ENCODE Transcription Factor Targets 1.0 null BRD-K11420482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72387 hsa-miR-4756-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Fetal_Intestine_Large Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -2.01319 Manganese HMDB Metabolites of Enzymes 1.0 null Creatinase/Aminopeptidase P, N-terminal InterPro Predicted Protein Domain Annotations 1.0 null GSE155162,GSE155169_1_v_0_buparlisib_human RummaGEO Drug Perturbation Signatures 1.0 null AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.29286 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 2.19064 etynodiol-6678 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K88087295 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82744 alfadolone-7262 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.12104 H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE166944_0_v_2_eif4b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Radula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.79 AMIGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04076 JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null flunisolide-3747 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-Q2AG-0626-SM-2S1PV GTEx Tissue Sample Gene Expression Profiles 1.0 1.1397 10663_ZNF830_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.895949 NUP88 Pathway Commons Protein-Protein Interactions 1.0 null planum temporale, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.19241 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.98796 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0692 GTEX-U3ZH-0626-SM-4DXT3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880861 HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.22284 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.91265 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OB-06-WW76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.67604 Olfactory bulb TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.143 BRD-K63504496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01278 BRD-K69466030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87202 GTEX-S32W-0626-SM-2XCBG GTEx Tissue Sample Gene Expression Profiles 1.0 1.11944 Polycystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.438 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lidocaine-1499 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839012 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Ofloxacin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0232542 DDX5 Pathway Commons Protein-Protein Interactions 1.0 null Disease of anatomical entity DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 abnormality of pancreas morphology HPO Gene-Disease Associations 1.0 null GP2D CCLE Cell Line Gene Expression Profiles 1.0 1.68801 pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.26385 BRD-K06284373 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25323 PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-GENE_DBP Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MI-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hypertension HPO Gene-Disease Associations 1.0 null GSE221327_5_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null ornidazole-1425 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35764 iobenguane-7299 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11495 glipizide-4991 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Bardet-Biedl syndrome 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.161 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.837673 Perturb_9498_KO_Lsd1_SRP096254 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.26842 H3K9me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5549-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATF3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null L428 DepMap CRISPR Gene Dependency 1.0 2.42816 vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076607 SPTAN1 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4098-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN010_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.67545 vesicle GO Cellular Component Annotations 2015 1.0 null BRD-K00048155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73314 Brain Lower Grade Glioma_LGG_TCGA-QH-A6CZ-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05436 hsa-miR-1304 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.7095 JA-02-IU07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.366522 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42115 L363 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.38041 BHLHE40 ENCODE Transcription Factor Targets 1.0 null GSE190322,GSE190324_3_v_4_rbm4_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100639_TCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.31068 GSE104508_2_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null Tadalafil_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0161958 SNU423_LIVER CCLE Cell Line Proteomics 1.0 7.33093 Charcot-Marie-Tooth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.037 GSE221327_1_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null Thymus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.48 BRD-K76342376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56124 BRD-K88559334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04263 Lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.852 pallidohypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04928 Nephronophthisis 11 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.874 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K46620987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01991 K562_Fluorouracil_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.019233 GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848668 GSE169205_3_v_7_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null zona incerta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.93093 Neurolemma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.549 PMC9068765-41467_2022_29960_MOESM14_ESM.xlsx-TP53-Annotation_TP53 Rummagene Transcription Factor Associations 2026 1.0 null glycopyrronium bromide-3427 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormality of cardiac morphology GWASdb SNP-Phenotype Associations 1.0 0.696681 abnormality of the kidney HPO Gene-Disease Associations 1.0 null EZH2_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLHDC8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06498 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4164-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null aminopeptidase activity GO Molecular Function Annotations 2015 1.0 null PFSK1 DepMap CRISPR Gene Dependency 1.0 2.28744 RTCB Pathway Commons Protein-Protein Interactions 1.0 null PHB Pathway Commons Protein-Protein Interactions 1.0 null trimipramine-4163 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.161484 Mitochondrial myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.232 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.6527 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEF2A ENCODE Transcription Factor Targets 1.0 null GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18092 SIN3A ENCODE Transcription Factor Targets 1.0 null vorinostat_homo sapiens_gpl570_gse34880 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TGBC1TKB DepMap CRISPR Gene Dependency 1.0 5.23995 Ciliopathies DisGeNET Gene-Disease Associations 1.0 null ZNF326 Pathway Commons Protein-Protein Interactions 1.0 null TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.08424 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDX41 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null mianserin-2068 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870582 GSE145639_1_v_2_adar_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF708 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9117 HCC2998 BioGPS Cell Line Gene Expression Profiles 1.0 1.0603 diloxanide-5025 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null prostatic hypertrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.86059 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EEF1A1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K25559116 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02425 Bipolar I disorder GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.652288 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-R55C-0626-SM-2TF4Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.877867 Adrenocortical carcinoma_ACC_TCGA-OR-A5JS-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211215_1_v_0_pemetrexed_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995252 Ganglion TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.225 BB-20-UU03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.938094 TFAP2E JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.2098 DD-43-WW40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364029 GSE44157,GSE44163_1_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65665 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XN-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE233679_12_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.335 Mitochondrial prohibitin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.982 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Corpus striatum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.083 A549_Andarine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168232 GSE180377_2_v_1_lipa_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNRPD1 Pathway Commons Protein-Protein Interactions 1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.11862 C1QBP Pathway Commons Protein-Protein Interactions 1.0 null SP in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11934 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein processing GO Biological Process Annotations 2015 1.0 null H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CDH1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K45245001 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24373 cinchonine-4107 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cell projection part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.405193 GSE161846,GSE161849_3_v_0_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Weight Gain CTD Gene-Disease Associations 1.0 1.01437 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WK11-0006-SM-3NB3J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27826 GSE178255_2_v_4_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03121 EEF1D Pathway Commons Protein-Protein Interactions 1.0 null GSE121246_1_v_0_stat5b_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14684 NCI-H1437 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.88046 Fibre tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.356 SKN Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.88812 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13589 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_12Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.11105 Neurofibrillary tangle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.439 BRD-A67521865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09671 PRELID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48748 CRCGN008_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16065 Endopeptidase Clp complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.692 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Aminopeptidase P, N-terminal InterPro Predicted Protein Domain Annotations 1.0 null HCaRG_OE_GDS2426_711_human_HEK293 kidney cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE226316_1_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16268355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03409 RPL31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21825 CRCGN016_MCF10A.TP53.M_24H:P10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.41659 A549_Momelotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142655 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4286 ZUP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08695 oxymetazoline-6350 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null nb4 HPA Cell Line Gene Expression Profiles -1.0 -1.10603 ANAPC5 Pathway Commons Protein-Protein Interactions 1.0 null NZOV9 DepMap CRISPR Gene Dependency 1.0 5.01117 HEK 293 T-rex BioGPS Cell Line Gene Expression Profiles 1.0 0.830554 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.911189 (-)-isoprenaline-3571 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE114883_1_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32154 BRD-K32185628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15395 primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.183415 IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.55699 A549_TG101209_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160365 BRD-K92978173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10398 GSE48812_11_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPD Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5495-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE131649_4_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null REST ENCODE Transcription Factor Targets 1.0 null TCF4_01_185 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60081 METTL17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21996 clobetasol-6835 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RL DepMap CRISPR Gene Dependency 1.0 3.86151 CRCGN009_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.29127 Perturb_7239_KO_CDK8_SRP271652 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSAP Pathway Commons Protein-Protein Interactions 1.0 null PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1 Rummagene Transcription Factor Associations 2026 1.0 null naproxen-2533 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.83732 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null pars intermedia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.547326 SRF ENCODE Transcription Factor Targets 1.0 null MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66216147 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79282 PAX5 ENCODE Transcription Factor Targets 1.0 null H4K5ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE245270_1_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K97798118 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2996 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12163 H3K79me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-1126-SM-4LMK4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05109 substantia innominata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.958926 cefotiam-3319 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE124014_0_v_1_nnmt_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE226249_2_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4695-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Pearson syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.255 SHMT1 Pathway Commons Protein-Protein Interactions 1.0 null ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.59317 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1051 GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.937581 Cerebellar disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.346 Diencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.493 MYOD1 ENCODE Transcription Factor Targets 1.0 null RPL12 Pathway Commons Protein-Protein Interactions 1.0 null A549_MLN8054_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.00971352 GSE158632_2_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.053 CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K34445019 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03202 endometrium_4a HPA Tissue Sample Gene Expression Profiles -1.0 -1.04763 Attachment organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.042 GSE158834_0_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPM Pathway Commons Protein-Protein Interactions 1.0 null amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40292 EW8 Achilles Cell Line Gene Essentiality Profiles 1.0 1.1972 globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21547 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045106 GSE145639_7_v_2_adar_human RummaGEO Gene Perturbation Signatures 1.0 null GSE169205_3_v_8_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null SUP-B8 COSMIC Cell Line Gene Mutation Profiles 1.0 null levonorgestrel-4269 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-PLZ6-1426-SM-2S1OQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.852094 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K25905181 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34215 PMC9170756-mmc6.xlsx-all_differential_proteins-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN Rummagene Transcription Factor Associations 2026 1.0 null BRD-K06719105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27432 CRCGN017_MCF10A.WT.HP_24H:O14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0771 GTEX-XUJ4-0326-SM-4BOP9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24654 A549_Alvespimycin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145244 hmc1 HPA Cell Line Gene Expression Profiles -1.0 -1.29318 hsa-miR-448 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 BRD-A66025870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40146 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03645 GSE142210_2_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE258991_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21854 BRD-K72681425 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04414 GSE149123,GSE149128_2_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-UJMC-0326-SM-3GAE2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31838 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Asphyxiating thoracic dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.694 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mefexamide-1438 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CE-15-YU05_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.300696 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IGR1 CCLE Cell Line Gene Expression Profiles 1.0 1.5916 Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.165 BRD-K89333198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39096 pheneticillin-6239 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ntera2cloned1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.732 hsa-miR-4691-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 type ii diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.446509 Midbrain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.356 BRD-K73479560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23477 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NFK9-1326-SM-3LK5I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15421 mcf7 HPA Cell Line Gene Expression Profiles 1.0 0.907823 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null A549_MC1568_10然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0121305 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02375 NCI-H1581 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -5.7703 H3K9me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K30310320 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26995 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2ES-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH292 CCLE Cell Line Gene CNV Profiles -1.0 -1.85901 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5359-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null neostigmine bromide-3294 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Sengers syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.327 ES-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null MCF7_PFI-1_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137786 arcuate nucleus of medulla, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.74768 CRCGN013_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28341 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04644 BRD-K39449566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14569 PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null TIMM50 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K45097650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16514 GSE158834_2_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Prefrontal cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.359 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.4289 DYRK2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K47584662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12521 oxymetazoline-2114 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TPM3 Pathway Commons Protein-Protein Interactions 1.0 null GSE193541_1_v_2_nifurtimox_human RummaGEO Drug Perturbation Signatures 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null mepenzolate bromide-4304 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44924 BRD-A24369193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18221 POLR2A_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Integral component of mitochondrial inner membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.13 H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GRANTA519 CCLE Cell Line Gene Expression Profiles 1.0 1.843 diltiazem-1532 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null UQCC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11976 FLI1_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QV44-0526-SM-2S1RE GTEx Tissue Sample Gene Expression Profiles 1.0 1.31338 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5978-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU886 DepMap CRISPR Gene Dependency 1.0 2.31363 BRD-K47083242 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86035 GSE216540_0_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null TERF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84341 PMC10746608-427_2023_709_MOESM5_ESM.xlsx-NR3C1_partners-NR3C1_known_protein_partners_according_to_BioGrid_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00233 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.194257 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842914 furaltadone-3413 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CDK8_knockdown_88_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.68512 KNS81 CCLE Cell Line Gene CNV Profiles -1.0 -1.52016 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_10_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Nephronophthisis 18 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.761 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14849 IZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12174 PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1794 LIMA1 Pathway Commons Protein-Protein Interactions 1.0 null eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.858223 GTEx Uterus 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 14.4216 BRD-K79665135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1758 FOXP2 ENCODE Transcription Factor Targets 1.0 null GSE242199_2_v_3_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.830285 Testis BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.919117 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3317-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_CUDC-101_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0188396 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE154577_6_v_5_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.828406 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4762-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.74571 GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_8_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.064348 GSE216540_1_v_6_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90527 SW837_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 2.87688 BRD-K98408839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76458 GTEx Esophagus 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures 1.0 6.69961 urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.652589 HNRNPH2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K93624320 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62242 FLT1_knockdown_111_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.607 FE-64-KC49_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.15285 GSE105169,GSE105175_0_v_1_dhx36_human RummaGEO Gene Perturbation Signatures -1.0 null GSE145311_1_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC10260721-43657_2023_100_MOESM10_ESM.xlsx-MR_for_neuro-traits_FDR_0_05-Gene_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.2039 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21114 HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.319 CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nephronophthisis DisGeNET Gene-Disease Associations 1.0 null BRD-K60337657 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29413 GSE193258,GSE193259_9_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null 4951_MED28_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.03363 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.009 BRD-K47776393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47922 CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null XRCC5 Pathway Commons Protein-Protein Interactions 1.0 null Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.168 JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.879632 GSE148692,GSE148695_5_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE142430_3_v_0_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-632 TargetScan Predicted Conserved microRNA Targets 1.0 0.029271 A549_Entacapone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0207946 Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cinoxacin-6257 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Momelotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.019387 pioglitazone_mus musculus_gpl2897_gse8806 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary metabolic process GO Biological Process Annotations 2015 1.0 null hsa-miR-378 TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 Amyloid plaque TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.434 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06021 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4739 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OE-01A-11R-A206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242333_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE135514_2_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE193751_1_v_3_oridonin_human RummaGEO Drug Perturbation Signatures 1.0 null 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.27259 proxymetacaine-3113 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE178532_1_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null KRT14 Pathway Commons Protein-Protein Interactions 1.0 null GSE157777_1_v_3_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null A549_TG101209_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159175 Cells - EBV-transformed lymphocytes GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.827565 K562_RG108_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176272 valproic acid-5237 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K08442552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.08612 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26991 Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.2604 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNRPC Pathway Commons Protein-Protein Interactions 1.0 null primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.979564 YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IN-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YAE1D1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_astrocyte of the cerebellum_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ar_21330406_lncap_lof_human_gpl570_gds4113 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 3.34929 BRD-K15174326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18302 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 C22orf39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51722 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21012 MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.746372 GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81668 PMC8528285-pbio.3001085.s010.xlsx-Fig_S8D-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_WT_3T3_ONLY_1626_GENES_MNT Rummagene Transcription Factor Associations 2026 1.0 null cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.971972 COLO741 CCLE Cell Line Gene CNV Profiles 1.0 1.5444 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MMP2 Pathway Commons Protein-Protein Interactions 1.0 null testis_7e HPA Tissue Sample Gene Expression Profiles 1.0 2.45203 MYC-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Cyanelle envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.964 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3306-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null manganese ion binding GO Molecular Function Annotations 2015 1.0 null postcentral gyrus, right, inferior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08963 BRD-K75981085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29203 BRD-K89652482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53241 MCF7_ABT-737_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139952 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.92757 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TJ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42221 GSE156923_2_v_3_rbmx_human RummaGEO Gene Perturbation Signatures -1.0 null TC106 DepMap CRISPR Gene Dependency 1.0 4.30591 subthalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.82554 MCF7_Dacinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00719451 Mitochondrial ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.357 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FUOV1 CCLE Cell Line Gene Expression Profiles -1.0 -2.73215 BRD-K80965028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1999 GSE226249_2_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null cv-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.183195 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Kco TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.822 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.27882 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null thiamphenicol-1826 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Sarcoma_SARC_TCGA-DX-A1KX-01A-22R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K20879770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39032 hsa-miR-378f TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 Centriolar satellite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.097 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Minor vestibular gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.528 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7237 K562_PF-3845_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.01935 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZK-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K50685439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36216 A549_ZM 447439_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0111541 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K75606012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13838 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null STK4 Pathway Commons Protein-Protein Interactions 1.0 null JHH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.829605 Cystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.868 H3K18ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053591 MAX_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE195559_6_v_1_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12529 ANAPC1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-802 TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 carbohydrate metabolism disease GWASdb SNP-Disease Associations 1.0 0.297546 ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.786 CAL148 CCLE Cell Line Gene CNV Profiles -1.0 -1.98247 RAD21 ENCODE Transcription Factor Targets 1.0 null blood GTEx Tissue Gene Expression Profiles -1.0 -1.52699 IRF1 ENCODE Transcription Factor Targets 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MCF7_IOX2_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149239 gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.083239 WRNIP1 ENCODE Transcription Factor Targets 1.0 null UBLC1_URINARY_TRACT CCLE Cell Line Proteomics 1.0 2.86771 JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235392 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.7215 A549_Flavopiridol HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0111446 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32438 CRCGN014_HEPG2_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.78584 primary motor cortex (area M1, area 4)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47892 PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null KRT9 Pathway Commons Protein-Protein Interactions 1.0 null HNRNPF Pathway Commons Protein-Protein Interactions 1.0 null cycloserine-7134 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1 Rummagene Transcription Factor Associations 2026 1.0 null RPL21 Pathway Commons Protein-Protein Interactions 1.0 null TMOD3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WL46-0011-R10A-SM-3MJFQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04553 Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8765 BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68916 BRD-K35909757 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26794 BRD-K21470524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.61832 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.122944 POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FGFR3_knockdown_34_GDS4454 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 3.04479 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.999565 NCI-H1838 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.07593 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K78196882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34035 SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXK2 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_0_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-3136-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 BRD-K73463737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02715 BRD-K48593237 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19747 RPTN Pathway Commons Protein-Protein Interactions 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null GNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34624 Respiratory chain complex III COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.274 LY-294002-1216 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XPVG-2826-SM-4B66J GTEx Tissue Sample Gene Expression Profiles 1.0 1.12841 Brush border membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.845 MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0826-SM-2HMK7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23425 C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05309 GSE124471,GSE124488_1_v_3_lats1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Renal Insufficiency CTD Gene-Disease Associations 1.0 1.09681 BRD-K40011635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.43917 CRCGN009_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.13215 Superior temporal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.749 Prestwick-972-7266 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Wt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 67.9452 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29016 posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.30837 abnormality of the meninges HPO Gene-Disease Associations 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZWINT Pathway Commons Protein-Protein Interactions 1.0 null SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SLR24 CCLE Cell Line Gene CNV Profiles -1.0 -1.32983 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUP Pathway Commons Protein-Protein Interactions 1.0 null HNRNPUL1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_16739_KO_Gcn5_SRP271119 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.58757 lynestrenol-6756 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Sarcoma_SARC_TCGA-DX-A8BT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null smallintestine_4d HPA Tissue Sample Gene Expression Profiles -1.0 -1.15089 Cystocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.548 MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949213 BRD-K98976117 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54652 striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.914332 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 67.2731 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F4-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RUNX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6077 HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0079 NRF1 ENCODE Transcription Factor Targets 1.0 null layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.11364 HERC2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K94962942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56112 7538_RPS8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.524627 A549_Curcumin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152897 PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Renal epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.183 GTEX-QDT8-0326-SM-32PL1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2267 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null RPLP0 Pathway Commons Protein-Protein Interactions 1.0 null IRF3 ENCODE Transcription Factor Targets 1.0 null GSE189859,GSE189861_0_v_2_idh1_human RummaGEO Gene Perturbation Signatures -1.0 null binding GO Molecular Function Annotations 2015 1.0 null KLF4-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-46-3765-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.870154 RPS8 Pathway Commons Protein-Protein Interactions 1.0 null disease of anatomical entity DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null BRD-K54003455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06072 metalloexopeptidase activity GO Molecular Function Annotations 2025 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22728 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.837411 GSE221633_3_v_1_trim24_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A30758703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5127 QGP1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.16587 GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45807 GTEx Brain 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 11.2144 K562_Lapatinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148441 GSE166920_6_v_2_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.8536 RASSF5 Pathway Commons Protein-Protein Interactions 1.0 null embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056299 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054295 NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE236497,GSE236500_1_v_0_pemrametostat_human RummaGEO Drug Perturbation Signatures 1.0 null cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26766 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cerebral gyrus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.272 molsidomine-6325 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.17629 Anemia CTD Gene-Disease Associations 1.0 1.55822 Mitochondrial intermembrane space COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.875 chr22_40957451_G_T_b38 GTEx eQTL 2025 1.0 1.73963 Cognitive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.512 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09238 RELA ENCODE Transcription Factor Targets 1.0 null CREB MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86698 GSE206516,GSE206518_0_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.075494 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null USF2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mood disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.512 Kearns-Sayre syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.264 RPL37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19225 U87MG Achilles Cell Line Gene Essentiality Profiles 1.0 1.05789 bromperidol-7457 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZSCAN16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.0412 CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TT Achilles Cell Line Gene Essentiality Profiles -1.0 -1.00277 CAOV3 CCLE Cell Line Gene CNV Profiles 1.0 2.60028 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-dORF6_96Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.26598 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-RQ-A68N-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XMK1-2426-SM-4B66I GTEx Tissue Sample Gene Expression Profiles 1.0 0.999653 BCL2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43079 PMC4090731-bjc2014262x1.xls-Sheet1-CaSig-HSF1_Positive_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE193588_1_v_2_pax3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE158815_5_v_3_trib1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null BRD-K57795803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35753 icSARS CoV_0Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.78704 inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.977465 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MSTO-211H Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.76066 GSE158834_12_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K09131889 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54119 CANX Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-935 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Ivosidenib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156834 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null MDAMB435S CCLE Cell Line Gene CNV Profiles 1.0 1.63248 BRD-K33274327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.30358 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QI-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null oxedrine-3578 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2972-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KRT10 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN017_MCF10A.WT.HP_24H:N22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9858 CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_10_v_5_palm_human RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.93615 GSE150895,GSE150896_0_v_1_kif15_human RummaGEO Gene Perturbation Signatures -1.0 null GSE189683_3_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HT29 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.69873 BRD-K66963616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23766 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855462 K562_RG108_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145865 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 1.08292 BRD-K84178479 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36315 benfluorex-5327 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-1 MiRTarBase microRNA Targets 1.0 null Entospletinib DeepCoverMOA Drug Mechanisms of Action 1.0 0.39 K562_Lapatinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166716 BRCA1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10746608-427_2023_709_MOESM5_ESM.xlsx-SOX2_partners-SOX2_known_protein_partners_according_to_BioGrid_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN017_MCF10A.TP53.M_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.51476 hsa-miR-770-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 LK2 Achilles Cell Line Gene Essentiality Profiles 1.0 1.35006 disease of metabolism GWASdb SNP-Disease Associations 1.0 0.104042 primary auditory cortex (core)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02652 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04187 GSE98898_8_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null Tracheal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.925 BRD-K20733942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98413 EEF1B2 Pathway Commons Protein-Protein Interactions 1.0 null midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.28766 SRSF7 Pathway Commons Protein-Protein Interactions 1.0 null 3-methylglutaconic aciduria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.325 SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5668 BRD-K86593041 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.015 gramine-4118 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K30615964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41135 Autosomal dominant cerebellar ataxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7918-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.876915 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14145 peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42534 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.23567 Plant primordium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.751 A549_Roscovitine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179162 TE11 DepMap CRISPR Gene Dependency 1.0 4.79934 Omeprazole_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0153653 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4834-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31203610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28561 IZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.302 GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66776 BRD-A20208638 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21352 globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.45533 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.55846 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217552_3_v_2_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null H2AK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K81322049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4762 BRD-K37277666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30529 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE155852_0_v_2_apigenin_mouse RummaGEO Drug Perturbation Signatures 1.0 null pancreatitis HPO Gene-Disease Associations 1.0 null GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 2.42728 EP300_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null colecalciferol-2436 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01798 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.188808 peptidase activity GO Molecular Function Annotations 2015 1.0 null secalciferol LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23763 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0753 Photosynthetic membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.007 phenotypic abnormality HPO Gene-Disease Associations 1.0 null BRD-K69613314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90779 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.985792 NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43186 GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null OV-7 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.6 GSE198165,GSE198166_7_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K08730943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2213 POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null valproic acid-1163 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-2W-A8YY-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null prednicarbate-5544 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.28365 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K79152256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39519 GSE108614,GSE108615_3_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K66754362 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90945 HDAC6 ENCODE Transcription Factor Targets 1.0 null abnormality of the arachnoid mater HPO Gene-Disease Associations 1.0 null hsa-miR-548b-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K91ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.42215 BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.210705 PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null NUP210 Pathway Commons Protein-Protein Interactions 1.0 null A549_AC480_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016559 A549_Nilotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0220566 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17508 Lung squamous cell carcinoma_LUSC_TCGA-22-5477-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K26435104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04576 intellectual disability HPO Gene-Disease Associations 1.0 null TD-31-KS49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.392901 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K07615667 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04261 HT-22 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.641 BRD-K69987634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06864 RPRD1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30959 CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4496 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.831708 N6-methyladenosine-5332 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPL4 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11069_OE_Ccne1_SRP185695 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.72436 CB-44-RT90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.68573 JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-548d-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.43684 BRD-K04317371 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50024 BRD-K47966145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95663 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PK59 CCLE Cell Line Gene CNV Profiles -1.0 -1.53262 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A684-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4469 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 FE-64-KC49_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.298803 BRD-K58284640 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12556 Twig TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.515 GTEX-OOBJ-2626-SM-2I3F6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36898 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.940431 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K41382866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12726 GB-46-CK08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.22835 PRDX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08294 Lung squamous cell carcinoma_LUSC_TCGA-60-2723-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded vesicle GO Cellular Component Annotations 2015 1.0 null A549_AC480_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0247419 NSL1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GGTLC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08608 duodenum_4b HPA Tissue Sample Gene Expression Profiles -1.0 -2.46769 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.727 Mitochondrial intermembrane space protein transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.867 SIRT6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Developmental and epileptic encephalopathy 23 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.265 IMCD cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.537 ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851853 BRD-K91094364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53777 fusiform gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19183 BRD-K45694673 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69208 GSE232223_1_v_0_letmd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A4ZV-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null reticular nucleus of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27507 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-606 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE169205_3_v_1_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPAEC cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.559 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KRT77 Pathway Commons Protein-Protein Interactions 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null COACH syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.01 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.864169 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HNRNPC Pathway Commons Protein-Protein Interactions 1.0 null caudal ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.982258 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18864 Uterine Carcinosarcoma_UCS_TCGA-NF-A4WU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.56736 ZNF263 ENCODE Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.74835 TCP1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K90316899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45429 BRD-K73994499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19734 GSE206516,GSE206518_6_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null BRD-K05657319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28603 Autosomal recessive polycystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.533 GTEX-Q2AH-0726-SM-2I3EA GTEx Tissue Sample Gene Expression Profiles 1.0 1.24389 GSE226249_5_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K36422663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14108 BRD-K15943105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28013 End stage renal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.122 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47742 Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Johnston's organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.563 HNRNPK Pathway Commons Protein-Protein Interactions 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null TBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33695 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3387-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPC25 Pathway Commons Protein-Protein Interactions 1.0 null Peripheral Nervous System Diseases CTD Gene-Disease Associations 1.0 1.13997 LD-69-ZV56_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214719 ivermectin-1367 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC12697907-ADVS-12-e07451-s002.xlsx-ST4E_MR-pancanQTL-Unnamed_1_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null SKNSH CCLE Cell Line Gene CNV Profiles -1.0 -2.11167 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K79517375 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34001 SF3B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4498 PMC6977700-aging-12-102667-s004..xlsx-Stage3-The_identified_641_dysregulated_LmiRM-CTs_in_stage_3_of_MI_1_month_after_MI_using_our_method_MITF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.084308 CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.82975 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37001 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null CC-03-PW00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.409699 TIAM1 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HSD17B10 Pathway Commons Protein-Protein Interactions 1.0 null MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.01216 GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9666 hsa-miR-548j TargetScan Predicted Conserved microRNA Targets 1.0 0.474009 primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.52571 CLTC Pathway Commons Protein-Protein Interactions 1.0 null BRD-K69035249 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81239 GTEX-W5WG-2326-SM-3GIJH GTEx Tissue Sample Gene Expression Profiles 1.0 0.933357 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.980251 Helper T-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.369 hsa-miR-25 TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 A549_Resveratrol_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0205495 DMS-53 COSMIC Cell Line Gene Mutation Profiles 1.0 null Optic atrophy 11 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.05 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3545-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GSE48812_2_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null HSF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1198 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4521181-oncsis201520x8.pdf-29-TBX18_TBX18 Rummagene Transcription Factor Associations 2026 1.0 null Parahippocampal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.654 POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDC26 Pathway Commons Protein-Protein Interactions 1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K48615268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82413 Parenchyma TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.511 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08345 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-4591-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null creb1_22108299_lung_lof_mouse_gpl1261_gds3660 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.454613 Brain Lower Grade Glioma_LGG_TCGA-DU-6410-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_3H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00071 CRCGN017_MCF10A.WT.HP_24H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.31995 system process GO Biological Process Annotations 2015 1.0 null BRD-K43700313 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0605 PA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75492 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67532 ANAPC4 Pathway Commons Protein-Protein Interactions 1.0 null YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.62198 PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-geneid_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null prochlorperazine-1286 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Down syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.368 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8031408-pone.0249773.s002.xlsx-ST12-S12_Table_Genes_with_selection_signals_located_at_GeneHancer_elements_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7129-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_9076_KD_SRSF7_SRP365961 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE158834_1_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE131649_6_v_3_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null CDK7_knockdown_124_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.63244 GTEX-T2IS-2026-SM-4DM6W GTEx Tissue Sample Gene Expression Profiles 1.0 0.879968 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A3LQ-01A-21R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gemfibrozil-1430 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SKMEL2 BioGPS Cell Line Gene Expression Profiles 1.0 1.67882 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A685-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCK-81 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.9004 H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K77060313 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84202 BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203984 KRT16 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE202134_0_v_1_rbm39_human RummaGEO Gene Perturbation Signatures 1.0 null A549_Divalproex Sodium_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153477 REC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.71681 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826628 GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4339 GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.51483 Neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.174 DA-33-BM26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.679071 GTEX-RWS6-2426-SM-2XCB9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.83679 acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.169117 GSE158834_10_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null cisplatin_homo sapiens_gpl570_gse23553 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SHSYSY-RA BioGPS Cell Line Gene Expression Profiles -1.0 -0.860593 GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3022 Autism spectrum disorder or schizophrenia GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.8 Sarcoma_SARC_TCGA-K1-A42X-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null GTEX-OHPK-1326-SM-3MJGN GTEx Tissue Sample Gene Expression Profiles 1.0 1.0044 Dendritic cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.679 CCT7 Pathway Commons Protein-Protein Interactions 1.0 null GSE140651,GSE140653_2_v_1_med1_human RummaGEO Gene Perturbation Signatures -1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPA2B1 Pathway Commons Protein-Protein Interactions 1.0 null EF-52-ML96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.352765 supramarginal gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.845632 CHP-212 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.881077 striatum_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53872 ML264_CHP-212 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0120224 TJP1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN010_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56129 BRD-K89767945 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46287 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Hesperadin_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0135738 RXRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.6538 Thorax TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.48 HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null PK-15 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.67 (+)-chelidonine-6236 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K00914921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69154 GSE132948,GSE132949_0_v_1_msi2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:N23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4126 decreased grip strength IMPC Knockout Mouse Phenotypes 1.0 null LOXIMVI CCLE Cell Line Gene Expression Profiles -1.0 -2.09957 PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199899_3_v_2_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null MEWO_SKIN CCLE Cell Line Proteomics 1.0 3.25989 Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null obesity GWASdb SNP-Phenotype Associations 1.0 0.696681 BRD-A11130173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92711 PAX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5972 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_2_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4XX-0926-SM-46MV7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21443 BRD-K28764680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78843 hsa-miR-4275 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Zbtb2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.2434 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inner SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33079 sulfamethoxazole-3667 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null propantheline bromide-3013 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K89514545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86028 hsa-miR-4293 TargetScan Predicted Conserved microRNA Targets 1.0 0.15008 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null GTEX-PWCY-0226-SM-48TD8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.830176 USP49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62083 cyanocobalamin-3252 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Signal peptidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.099 BRD-K77727343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48049 CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDC80 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K75625428 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19469 GTEX-WYJK-1626-SM-3NM9J GTEx Tissue Sample Gene Expression Profiles 1.0 0.854117 BRD-K44344720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40666 HEC6 CCLE Cell Line Gene CNV Profiles 1.0 1.79099 hsa-miR-302f TargetScan Predicted Conserved microRNA Targets 1.0 0.248923 GTEx BloodVessel 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures 1.0 8.9979 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.837583 renal system process GO Biological Process Annotations 2015 1.0 null BRD-K06367273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35267 H3K56ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Mitochondrial outer membrane translocase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.645 clorgiline-6659 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7051-01A-12R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prestwick-972-3132 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-4455 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Brain Lower Grade Glioma_LGG_TCGA-CS-5394-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.83954 cefazolin-7385 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.293281 Perturb_5169_KO_Ddx5_SRP068412 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.34904 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.843618 NANOG_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BSX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27651 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29L-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.314772 BRD-K82729862 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46803 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null B-lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.852 abnormality of the inner ear HPO Gene-Disease Associations 1.0 null hsa-miR-4803 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE112761,GSE112767_4_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null AP-3 adaptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.006 glomerular filtration GO Biological Process Annotations 2025 1.0 null GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 2.03441 encodes GeneRIF Biological Term Annotations 1.0 null Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.148 A549_Celecoxib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0133105 GTEX-T6MN-0011-R10A-SM-32QP7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888741 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RN-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XYKS-0926-SM-4BRVG GTEx Tissue Sample Gene Expression Profiles 1.0 1.05455 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.326 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SSB Pathway Commons Protein-Protein Interactions 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MSTO-211H COSMIC Cell Line Gene Mutation Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null AF-16-IB77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245765 IZ in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.910101 GTEX-T8EM-0006-SM-3DB71 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3627 PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_5_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-K45894579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.30158 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6577 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Neurotoxicity Syndromes CTD Gene-Disease Associations 1.0 1.1862 GTEX-PLZ4-1226-SM-2I5FE GTEx Tissue Sample Gene Expression Profiles 1.0 1.00922 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATRFLOX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.833945 ChIP_TCFCP2L1_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97988 SARS-CoV MA15_Day1-PFU-10^3_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 3.11345 GSE216273,GSE216292_14_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GSTO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86354 tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7913-01B-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TMMY-0126-SM-4DXTP GTEx Tissue Sample Gene Expression Profiles 1.0 0.893293 ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Hereditary spastic paraplegia 7 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.142 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00602 BA-06-RE84_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250799 ANKRD33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82039 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-181c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4526 TargetScan Predicted Conserved microRNA Targets 1.0 0.09606 496100277_FWM_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.07873 COR-L279 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.91874 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-T5JC-0011-R1A-SM-32PM6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824454 OE19 CCLE Cell Line Gene CNV Profiles 1.0 2.08643 Nephronophthisis-like nephropathy ClinVar Gene-Phenotype Associations 2025 1.0 null HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.57351 CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-412 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Perturb_3227_KO_Gnas_SRP285875 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.3947 GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 2.02783 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51855 BRD-K12665145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.49395 SKMEL2 CCLE Cell Line Gene Expression Profiles 1.0 2.671 Ink sac TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.777 seckel syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.16179 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03792 RCOR1 ENCODE Transcription Factor Targets 1.0 null PMC12103066-FEBS-292-2688-s001.pdf-163-LCOR_LCOR Rummagene Transcription Factor Associations 2026 1.0 null embryonic fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.078923 BRD-K29662535 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54173 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null clotrimazole-6207 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NUP37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24121 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.73796 GTEX-WH7G-1526-SM-4LVMX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845563 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962867 GSE158834_10_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-N7MS-0526-SM-4E3JP GTEx Tissue Sample Gene Expression Profiles 1.0 0.848111 HADHA Pathway Commons Protein-Protein Interactions 1.0 null nephronophthisis DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null TNFRSF1B Hub Proteins Protein-Protein Interactions 1.0 null BRD-K92144896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90678 GSE238116_1_v_2_egr1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4715 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.45798 GSE216538_1_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-P4QS-1326-SM-3NMCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.26663 nih-3t3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.18186 primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.47188 A549_Nintedanib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0212664 retromer, cargo-selective complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.717 GSE226316_0_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null nitrendipine-6304 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null metallopeptidase activity GO Molecular Function Annotations 2015 1.0 null CTCF_GM12865_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS79 CCLE Cell Line Gene Expression Profiles -1.0 -1.56544 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Andarine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163586 mecamylamine-7263 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19114 ERK5-IN-2_hTERT-HPNE Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.00367196 GTEX-T6MO-2026-SM-33HB4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.866521 OC-314 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135514_8_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null STAT1 ENCODE Transcription Factor Targets 1.0 null haloperidol-5273 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01775 A549_MC1568_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155929 VZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.908622 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.906544 NCIH146 CCLE Cell Line Gene Expression Profiles -1.0 -1.50456 GTEX-QCQG-0008-SM-48U2G GTEx Tissue Sample Gene Expression Profiles 1.0 0.911621 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.65645 Joubert syndrome 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.893 NUF2 Pathway Commons Protein-Protein Interactions 1.0 null JUN_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_11_v_3_palm_human RummaGEO Gene Perturbation Signatures -1.0 null GSE166920_6_v_8_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO-783 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A91931411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74438 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.86528 PRPF8 Pathway Commons Protein-Protein Interactions 1.0 null iron-sulfur cluster assembly complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.632 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.668722 GSE169205_0_v_1_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE213588_10_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null all HPO Gene-Disease Associations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-194 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 BRD-K73780763 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08869 6862_PSMC5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.542544 GTEX-WH7G-0626-SM-4LVMO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862953 ZFP281-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null H4K20me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM6A-18722178-U937_AND_SAOS2-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-0626-SM-2TC5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.16405 GSE181821_1_v_3_mov10_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-548n TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 K562_TG101209_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0187437 A549_PFI-1_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164768 MCF7_NVP-BSK805 2HCl_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139598 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9560_KO_Marchf3_SRP278315 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.13176 DC-47-KV62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248036 GTEX-RUSQ-0226-SM-47JWT GTEx Tissue Sample Gene Expression Profiles 1.0 1.46765 BRD-K61661017 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27231 KCNH2 Pathway Commons Protein-Protein Interactions 1.0 null GSE199606_1_v_4_csf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-378b TargetScan Predicted Conserved microRNA Targets 1.0 0.632343 PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.90188 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null BRD-K63730594 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26634 precentral gyrus, right, superior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39242 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6362 BRD-K67556876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47151 CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10746 cingulate gyrus, parietal part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12266 GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.262 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.64372 MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PC-62-AQ92_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.523179 primary motor cortex (area M1, area 4)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.981008 BRD-K07502463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00406 IE-02-TR35_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278409 PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null Phycobilisome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.691 CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.0718 JUN ENCODE Transcription Factor Targets 1.0 null GSE213588_8_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null SARS-CoV_96Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.09678 ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5764 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Down_GTF3A Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-EZ-7264-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.874912 23132/87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34452 epitiostanol-2922 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K66831269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35131 BRD-K63584084 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69112 pancuronium bromide-7329 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.0 GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.57146 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null Left ventricular noncompaction DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.355 COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63524 NCI-H810 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE110708_0_v_3_adar_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K17474512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17013 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.89223 BRD-K76966915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64679 hearing impairment HPO Gene-Disease Associations 1.0 null TUBB1 Pathway Commons Protein-Protein Interactions 1.0 null Ribonuclease P complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.827 Bipolar disorder GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.669897 Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5140203-908 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PPARD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99739 BUB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE182680,GSE182683_7_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K71210410 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13768 thyroid gland HPA Tissue Gene Expression Profiles 1.0 1.34878 GSE147626_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.866039 Lymph node TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.394 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUDT21 Pathway Commons Protein-Protein Interactions 1.0 null DSN1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933317 AMPD1 Pathway Commons Protein-Protein Interactions 1.0 null KRT78 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_10874_OE_LIPA_SRP328944 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.2833 hsa-miR-377 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.3167 hsa-miR-548w TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 Mitochondrial inner membrane peptidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.944 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE239844_4_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null PANC0327 CCLE Cell Line Gene Expression Profiles -1.0 -1.64125 OE33 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.10213 SRF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01112 16715129-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null TUBB Pathway Commons Protein-Protein Interactions 1.0 null KLF4-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null DD-74-PJ26_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.242319 CRCGN010_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20721 PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA Rummagene Transcription Factor Associations 2026 1.0 null JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-1626-SM-48FD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25804 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.55917 GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 1.12888 terazosin-2530 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PAICS Pathway Commons Protein-Protein Interactions 1.0 null abnormality of cardiovascular system physiology HPO Gene-Disease Associations 1.0 null XPO1 Pathway Commons Protein-Protein Interactions 1.0 null naproxen-7146 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null chlorpromazine-426 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intramolecular phosphotransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.917 protriptyline-6338 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null MSTO211H CCLE Cell Line Gene Expression Profiles -1.0 -1.60444 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSMA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54685 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 Brain Lower Grade Glioma_LGG_TCGA-HT-A617-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null mRNA_ASCL1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null CRCGN011_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56825 hsa-miR-378d TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 A549_Bisindolylmaleimide IX_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157511 hsa-miR-3160-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-367 TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.60302 GSE147876,GSE147877_4_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Polycystin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.999 gallbladder HPA Tissue Protein Expression Profiles 1.0 0.703068 CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null aminopeptidase activity GO Molecular Function Annotations 2025 1.0 null PMC11601903-jciinsight-9-175998-s107.pdf-4-WT1_WT1 Rummagene Transcription Factor Associations 2026 1.0 null KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25033 seminal vesicle HPA Tissue Protein Expression Profiles 1.0 0.703068 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3784 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5629-01A-01R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null trichostatin A-4526 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Peptidase M24, structural domain InterPro Predicted Protein Domain Annotations 1.0 null H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPLP2 Pathway Commons Protein-Protein Interactions 1.0 null Photosystem II oxygen evolving complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.781 SBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80218 Lung squamous cell carcinoma_LUSC_TCGA-21-1075-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null acenocoumarol-2077 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Aminoglutethimide_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015269 H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BE-38-UW72_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.9402 GSE215351,GSE215794_2_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.92236 protein metabolic process GO Biological Process Annotations 2025 1.0 null Ovarian fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.632 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.81874 BRD-K17372597 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25859 Neurofibrillary tangle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.974 TXN Pathway Commons Protein-Protein Interactions 1.0 null LN319 CCLE Cell Line Gene Expression Profiles -1.0 -1.84385 ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hydrochlorothiazide-1487 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE119978,GSE180930_3_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Combined oxidative phosphorylation deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.366 ofloxacin-7372 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GCM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98761 BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.21209 hsa-miR-378i TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 GSE136742,GSE136744_2_v_3_setd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE125219,GSE125221_3_v_8_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE103068_0_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3786 amitriptyline-1865 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cyclobenzaprine-3268 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A549_Veliparib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013474 BBSome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.266 abnormality of nervous system physiology HPO Gene-Disease Associations 1.0 null DAP3 Pathway Commons Protein-Protein Interactions 1.0 null HSPA9 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K11518913 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06276 LCLC-103H Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.26788 H3K79me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-520c-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-OHPN-0011-R4A-SM-2I5FD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920821 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.43893 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K53094498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03625 BB-20-UU03_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207004 BRD-K68995447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35176 CRCGN016_MCF10A.TP53.M_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.13267 abnormality of carbohydrate metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.283685 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 2.15109 Z granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.667 morphological abnormality of the central nervous system HPO Gene-Disease Associations 1.0 null ornidazole-2109 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3784 Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney disorder ClinVar Gene-Phenotype Associations 2025 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5768-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null K562_Tubastatin A HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157883 hsa-miR-4712-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 CC-04-WK34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.380768 smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.141558 GLO1 Pathway Commons Protein-Protein Interactions 1.0 null Mobilized_CD34_Primary_Cells_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.935312 K562_ENMD-2076 L-Tartaric acid_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151549 MAX ENCODE Transcription Factor Targets 1.0 null amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.936508 GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90089 GSE196699_7_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.5044 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metalloexopeptidase activity GO Molecular Function Annotations 2023 1.0 null CRCGN009_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.59314 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55808 BRD-K49721311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08181 GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 1.79014 1013_C18ORF32_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.52272 GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.072929 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EJM DepMap CRISPR Gene Dependency 1.0 5.55634 hsa-miR-4539 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BRD-K10812033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04015 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210682_0_v_1_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null homochlorcyclizine-5998 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OXRO-1226-SM-48TDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.35544 GSE102757_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures 1.0 null aconitine-7149 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE145639_1_v_4_adar_human RummaGEO Gene Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28915 ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.7458 PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE183335,GSE183351_1_v_2_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.01162 SNU410 CCLE Cell Line Gene CNV Profiles -1.0 -2.75757 MAX_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4395_KD_SUV39H1_SRP290196 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Danusertib_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.00970582 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.842578 ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null phenelzine-4538 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YY-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 4107_IMP3_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.03201 GSE229671,GSE229673_2_v_1_yrdc_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_15036_KD_Ctcflos_SRP311201 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.442 NCI-H2135 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11285 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8389 abnormal renal physiology HPO Gene-Disease Associations 1.0 null SARS-dORF6_84Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.3511 GTEX-U8XE-0005-SM-3DB8I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928366 GTEX-S341-1326-SM-4AD72 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21543 MYC_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null LCLC-103H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.90722 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49519 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPL-0426-SM-3TW8X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22627 Tolmetin_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0209914 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null BRD-K36764343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19501 AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null CAPAN2 CCLE Cell Line Gene Expression Profiles -1.0 -1.64266 GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.21298 EVSAT CCLE Cell Line Gene Expression Profiles 1.0 1.90128 BRD-K39499927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17462 POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.6661 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22288 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.76639 BRD-K86805916 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51923 SF767 DepMap CRISPR Gene Dependency 1.0 3.32072 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pioglitazone-7083 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Nephronophthisis DisGeNET Gene-Phenotype Associations 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null thyroid_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.996277 GTEX-T5JC-0011-R8A-SM-32PLM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.929442 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5004-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACSM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29208 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HEV_60Day_None_GSE53731 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.65133 Signal recognition particle, endoplasmic reticulum targeting COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.711 GSE147876,GSE147877_2_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K48689133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05912 GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.24102 LNCAP BioGPS Cell Line Gene Expression Profiles 1.0 0.916939 galantamine-4772 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EEF1G Pathway Commons Protein-Protein Interactions 1.0 null cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.33592 GSE199541_2_v_4_mbd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SREBF2 JASPAR Predicted Transcription Factor Targets 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HAX1 Pathway Commons Protein-Protein Interactions 1.0 null Schizophrenia GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.2 abnormality of the cardiovascular system HPO Gene-Disease Associations 1.0 null valproic acid-410 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE139239_2_v_6_ddr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.77519 PIFO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14095 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FLG Pathway Commons Protein-Protein Interactions 1.0 null BRD-K45013233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04247 GSE242290_1_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 2.09473 PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S3-Table_S3_MR_results_of_the_586_significant_genes_from_TG_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null HSPA7 Pathway Commons Protein-Protein Interactions 1.0 null cingulate gyrus, retrosplenial part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.907262 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE191174_0_v_1_ccdc92_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.54778 HCFC1 ENCODE Transcription Factor Targets 1.0 null A549_PF-3845_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172784 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.540585 CRCGN009_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.568 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ciliary landscape WikiPathways Pathways 2024 1.0 null STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29584 oxolinic acid-2103 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE221633_0_v_1_trim24_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.66533 GSE210476_11_v_4_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null JHOM1 Achilles Cell Line Gene Essentiality Profiles 1.0 2.07578 line14 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.747 DEGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44265 SEC24C Pathway Commons Protein-Protein Interactions 1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -2.27743 CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83832060 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2827 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 129.227 BRD-A55025683 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08061 CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE240645_1_v_0_u90926_mouse RummaGEO Gene Perturbation Signatures 1.0 null KELLY DepMap CRISPR Gene Dependency 1.0 5.4466 BRD-K32495578 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.23126 GRN Pathway Commons Protein-Protein Interactions 1.0 null CCT2 Pathway Commons Protein-Protein Interactions 1.0 null lung TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8678 CRCGN009_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.23265 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11385366-Table2.xlsx-DBP-Overlapped_Gene_DBP Rummagene Transcription Factor Associations 2026 1.0 null Artery disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05328 GSE121824,GSE121826_0_v_8_scaf8_human RummaGEO Gene Perturbation Signatures -1.0 null Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.333 GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08327 mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.42974 MATR3 Pathway Commons Protein-Protein Interactions 1.0 null AHCY Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-8164-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178714_5_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null bronchus HPA Tissue Protein Expression Profiles 1.0 0.703068 Adrenal cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.083 GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05479 CSTA Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7219-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26315 mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12593 H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Buccal mass TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.631 betazole-1812 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSU DepMap CRISPR Gene Dependency 1.0 5.32009 dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67908 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Thylakoid lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.213 SUDHL10 DepMap CRISPR Gene Dependency 1.0 2.15227 MCF7_PF-573228_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146521 GSE119978,GSE180930_0_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PW2O-0226-SM-48TC7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12788 Visceral heterotaxy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.508 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.01163 HSPA1B Pathway Commons Protein-Protein Interactions 1.0 null inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.832784 BRD-K69564473 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90059 metronidazole-4141 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Aurora A Inhibitor I_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177743 H3K14ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CHP-126 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.56955 GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.86674 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13398 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.942 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the abdomen HPO Gene-Disease Associations 1.0 null COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.980251 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer II of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.892594 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K79228133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03878 GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78342 cos-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.38326 BRD-K12524155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46989 ZEB1 ENCODE Transcription Factor Targets 1.0 null MYC ChEA Transcription Factor Targets 1.0 null USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null tubular basement membrane disintegration HPO Gene-Disease Associations 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K43108627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6806 CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8961 diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EPLC272H CCLE Cell Line Gene CNV Profiles 1.0 1.40576 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Alzheimer's disease 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 SLC25A13 Pathway Commons Protein-Protein Interactions 1.0 null MAP1LC3B Hub Proteins Protein-Protein Interactions 1.0 null NIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00134 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K85996308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.42943 GSE81803,GSE81912_0_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Basal ganglion TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.225 GTEX-NFK9-1726-SM-3TW8P GTEx Tissue Sample Gene Expression Profiles 1.0 0.927475 pancreatic cysts HPO Gene-Disease Associations 1.0 null CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein homodimerization activity GO Molecular Function Annotations 2023 1.0 null FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.373002 Brain - Cerebellum GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.935477 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RUSQ-1026-SM-2TF6V GTEx Tissue Sample Gene Expression Profiles 1.0 1.21849 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Roscovitine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0125913 hsa-miR-4446-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 nalbuphine-2063 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22884 BRD-K38240683 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80853 hsa-miR-3673 TargetScan Predicted Conserved microRNA Targets 1.0 0.389112 Epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.688 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057244 Aural Atresia, Congenital DisGeNET Gene-Disease Associations 1.0 null BRD-K52231520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31909 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.537021 CCK81 CCLE Cell Line Gene Expression Profiles 1.0 1.91324 GSE240645_3_v_2_u90926_mouse RummaGEO Gene Perturbation Signatures -1.0 null Auditory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.049 GTEX-OIZI-1126-SM-3NB1F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09611 GSE195568_3_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null amoxapine-4996 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null pizotifen-3134 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K04336022 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32723 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null seizures HPO Gene-Disease Associations 1.0 null Paraplegia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.169 ATP5B Pathway Commons Protein-Protein Interactions 1.0 null HE-18-HV99_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207988 Squamous cell carcinoma of mouth_Oropharynx Epithelium_GSE3524 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.04852 GSE147876,GSE147877_4_v_9_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OHPN-0005-SM-2YUML GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27148 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Meckel syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A44068497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36748 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94385157 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70806 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null extracellular region part GO Cellular Component Annotations 2015 1.0 null MCM3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-SUCS-0226-SM-32PLQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.864498 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K27226238 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34608 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null A549_Mesna_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173522 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK4 ENCODE Transcription Factor Targets 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05375 POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DLAT Pathway Commons Protein-Protein Interactions 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.557263 clomipramine-4487 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABP MotifMap Predicted Transcription Factor Targets 1.0 null u937 HPA Cell Line Gene Expression Profiles -1.0 -1.23056 CEBPB ENCODE Transcription Factor Targets 1.0 null Prion disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.172 PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_D419G-STAT6_targets_in_Jurkats_1_STAT6 Rummagene Transcription Factor Associations 2026 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BF-29-LU75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203622 PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null CALU-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03427 K562_Costunolide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0200822 GSE217101_0_v_1_mcph1_mouse RummaGEO Gene Perturbation Signatures 1.0 null fenoprofen-4274 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A78085235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25933 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.81435 GTEX-WHWD-0426-SM-3LK83 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00117 guaifenesin-2569 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null vitamin c_homo sapiens_gpl6884_gse16590 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE124471,GSE124488_2_v_3_lats1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE230573_1_v_0_dcaf1_human RummaGEO Gene Perturbation Signatures 1.0 null A549_AT9283_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.013813 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04787 SKMEL28 BioGPS Cell Line Gene Expression Profiles 1.0 1.26707 POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null bepridil-1274 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE82032_3_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE57871_1_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.338149 membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null CRCGN008_HEPG2_24H:O16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0392 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSTF2T CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00386 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K88498468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11886 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CODAS syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.137 Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199606_6_v_4_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null nephronophthisis-like nephropathy 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.092 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_7303_OE_TMEM119_SRP279053 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -17.327 CDPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3933 dosulepin-5986 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HNRNPA1 Pathway Commons Protein-Protein Interactions 1.0 null GSE137702_2_v_1_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null pancreas HPA Tissue Gene Expression Profiles -1.0 -0.9405 CB-44-FA25_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.317744 gliclazide-2870 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null U2AF2 Pathway Commons Protein-Protein Interactions 1.0 null PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null BARHL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33059 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.404415 GSE129370_0_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-U3ZN-1426-SM-3DB87 GTEx Tissue Sample Gene Expression Profiles 1.0 0.986037 Motor neuron disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.152 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K20me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MA-88-CA03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237115 hsa-miR-16-5p MiRTarBase microRNA Targets 1.0 null PANC1 DepMap CRISPR Gene Dependency 1.0 2.01991 GSE140997_4_v_8_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:B18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.54375 PMC12697907-ADVS-12-e07451-s002.xlsx-ST4E_MR-pancanQTL-Table_S4E_The_Mendelian_randomization_estimates_using_eQTL_data_from_PancanQTL_database_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE155162,GSE155169_1_v_2_buparlisib_human RummaGEO Drug Perturbation Signatures 1.0 null orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.851326 cefixime-4567 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7J9-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K80739863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54188 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19114 GTEX-V1D1-0926-SM-4JBHQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.23248 CRCGN015_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31411 PAQR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33626 GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84311 hsa-miR-1827 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Outer mitochondrial membrane protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.559 spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.177813 A549_Avagacestat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159706 GSE226316_6_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PLEC Pathway Commons Protein-Protein Interactions 1.0 null BRD-K19734887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42184 GSE226249_0_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K46619710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88754 GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60468 abnormality of the urinary system physiology HPO Gene-Disease Associations 1.0 null SRF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3949 GSE197571_2_v_1_foxm1_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4515 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 BRD-K06573818 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46428 flunixin-3411 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PADI4-21655091-MCF7-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-191-3p MiRTarBase microRNA Targets 1.0 null GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.83096 BRD-A99402294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.13534 genistein-5232 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K35788497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59366 GSE216043_10_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null A549_Fulvestrant_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176092 PEF1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-REY6-0526-SM-2TF5M GTEx Tissue Sample Gene Expression Profiles 1.0 1.01297 MYC_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EEF1A2 Pathway Commons Protein-Protein Interactions 1.0 null Mitochondrial matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.008 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -2.41948 POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Flavopiridol HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.012829 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A4FUK CCLE Cell Line Gene CNV Profiles 1.0 1.57032 HSPA8 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nasopharynx HPA Tissue Protein Expression Profiles 1.0 0.703068 SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.29725 H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE118766_2_v_0_ifng_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S7SF-0526-SM-3K2BC GTEx Tissue Sample Gene Expression Profiles 1.0 0.829148 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.75796 IGF2BP1 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82292 nifurtimox-6608 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K00078503 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.91852 KDM4A ENCODE Transcription Factor Targets 1.0 null KA-71-CQ35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.602594 NCI-H290 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.22414 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15093 MAFK ENCODE Transcription Factor Targets 1.0 null nifenazone-1439 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEx Esophagus 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 9.4682 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.717 individuals GeneRIF Biological Term Annotations 1.0 null H3K9me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K02070226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50736 A549_SB431542_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132098 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A688-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_65_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.970943 seminal plasma TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.776494 HD-29-PZ41_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.29347 testosterone-5271 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X4EP-0726-SM-3P5YJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.839095 ATF2 ENCODE Transcription Factor Targets 1.0 null GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 BRD-K95578456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.98728 PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null striatum_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3385 BRD-K15008902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44945 LUC7L2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T5JC-0011-R10A-SM-32PM2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832755 LN215 CCLE Cell Line Gene Expression Profiles -1.0 -3.62471 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-QDVJ-0005-SM-2TC5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10505 fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 1.04679 GSE167373_0_v_3_rbfox1_human RummaGEO Gene Perturbation Signatures -1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -0.908736 Outer membrane protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.9 lateral nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.937818 etanidazole-2510 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE226544_1_v_0_hnrnpa2b1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.72547 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139455_2_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE213588_9_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null sensorineural hearing impairment HPO Gene-Disease Associations 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle GO Cellular Component Annotations 2015 1.0 null tiletamine-3137 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A549_Glesatinib(MGCD265)_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152691 RPL11 Pathway Commons Protein-Protein Interactions 1.0 null tribenoside-6328 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-51-4080-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nephronophthisis 14 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.143 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.478768 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4340-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null SK-N-SH cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.936 ELK4_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1 Rummagene Transcription Factor Associations 2026 1.0 null EP300_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null agranular insular cortex (area Iag) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.834344 female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-N7MS-0011-R10A-SM-2HMJK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931865 BRD-K43336921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14988 EE-98-PF86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.26885 etoposide_homo sapiens_gpl10558_gse33990 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-S32W-0126-SM-4AD61 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37486 GSE226770_1_v_0_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null metalloaminopeptidase activity GO Molecular Function Annotations 2023 1.0 null BRD-K68985225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33685 sulfadoxine-3547 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null dorzolamide-6142 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.615138 CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95792127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27797 ronidazole-3557 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38057 BRD-K47995281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06363 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89497 Monogenic disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 NB7 DepMap CRISPR Gene Dependency 1.0 7.59378 NCIH1568 DepMap CRISPR Gene Dependency 1.0 2.62056 PC-87-OG75_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214741 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null 9895_XPNPEP3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.516894 GTEX-QV44-0826-SM-2S1RG GTEx Tissue Sample Gene Expression Profiles 1.0 1.38316 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.895684 hsa-miR-129-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 KDM6A-18722178-U937-AND-SAOS2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24106 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.79 anterior lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.166315 Adrenocortical carcinoma_ACC_TCGA-PK-A5HB-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YMB1 CCLE Cell Line Gene CNV Profiles -1.0 -1.33442 MEF2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.88115 GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.86738 GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960644 GSE205729,GSE205731_2_v_0_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11825621-210_2024_3353_MOESM2_ESM.xlsx-AR-IL13_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-A69950438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14325 Eye degenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null A549_Pelitinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142566 BRD-K73092207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17665 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gastroesophageal cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GR-ST Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.3741 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZH-3026-SM-3NB1G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82794 PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE158834_1_v_3_palm_human RummaGEO Gene Perturbation Signatures -1.0 null HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.05258 Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null RXRA ENCODE Transcription Factor Targets 1.0 null metencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07631 apramycin-6614 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TAF7L-23326641-C3H10T1-2-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN010_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27067 K562_Ellagic acid_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184596 ML264_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0181901 H3K4me1_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FADU CCLE Cell Line Gene Expression Profiles 1.0 2.05324 BRD-K85720719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30882 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IR-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07054 CAKI-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.879632 A549_Rucaparib_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0183676 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5982-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54426 BRD-K34262858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03856 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null prochlorperazine-1215 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PADI4 ChEA Transcription Factor Targets 1.0 null NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.53078 YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null M059K Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21423 Heschl's gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15298 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.91265 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0274 GSE146982_3_v_6_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE258991_5_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Lenalidomide_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0243625 A549_S3I-201_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164697 8305C CCLE Cell Line Gene CNV Profiles 1.0 1.36267 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.083388 BRD-K57184082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47395 GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42191 S-layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.625 fenbufen-4279 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML ENCODE Transcription Factor Targets 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100596_FWM_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.62188 NCI-H1568 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.51253 BRD-A78982410 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51991 HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68675 Tou TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.727 DSP Pathway Commons Protein-Protein Interactions 1.0 null MDA-MB-361 COSMIC Cell Line Gene Mutation Profiles 1.0 null A549_BMS-536924_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162912 Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.23782 MAP1A Pathway Commons Protein-Protein Interactions 1.0 null layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07212 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE183251_4_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.725 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.913741 BRD-K52924481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30377 PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S7-Table_S7_Top_500_differentially_modified_gene_bodies_between_MM_and_its_precursors_in_AA_patients_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE213588_10_v_7_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null A549_Navitoclax_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013047 MOLM14 DepMap CRISPR Gene Dependency 1.0 3.67911 NHEK Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.08562 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.59602 hsa-miR-1321 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.81816 GSE172020_0_v_2_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Nucleolar chromatin COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.885 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null MCF7_Fasudil_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0137118 JARID1A-20064375-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11B-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-VUSG-0426-SM-3GIKD GTEx Tissue Sample Gene Expression Profiles 1.0 0.889548 BRD-K84601599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45705 GSE119978,GSE180930_6_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null fenbendazole-3888 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K18ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MIF Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-3185 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SOX9 ChEA Transcription Factor Targets 1.0 null BRD-K38358574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00185 hsa-miR-4666-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GATA1 ENCODE Transcription Factor Targets 1.0 null Cysteine synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.861 BRD-K90793170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23991 GSE172247,GSE172250_0_v_2_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K44203030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76467 BRD-K42496940 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08002 GSE166920_6_v_4_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_1_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:P11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00313 GSE115395_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K72685049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04284 GA-28-SS67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.426609 GABPA ENCODE Transcription Factor Targets 1.0 null BRD-K45712538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14063 fallopian tube HPA Tissue Gene Expression Profiles 1.0 1.13082 A549_SRT2104_100nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.011531 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 3.14057 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null T-lymphoblastic leukemia cell line TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3997 catalytic activity GO Molecular Function Annotations 2015 1.0 null tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.58462 PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null brain stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063713 A549_Aurora A Inhibitor I_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158325 PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S6-Table_S6_MR_results_of_the_significant_genes_from_human_brain_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39298 PMC10350077-media-7.xlsx-microglia_proteomics_LPS-Gene_Symbol_1_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211357_1_v_3_atg7_human RummaGEO Gene Perturbation Signatures -1.0 null Congenital myasthenic syndrome 22 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.21 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null A549_TGX-221_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163449 BRD-K56592061 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22425 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91219 BRD-K82521348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55326 MAP1S Pathway Commons Protein-Protein Interactions 1.0 null Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.157 GSE246461,GSE246463_5_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF75A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4661 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.903096 YBX3 Pathway Commons Protein-Protein Interactions 1.0 null A549_Glesatinib(MGCD265)_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149269 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A54490075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74825 BRD-K70116387 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29145 mebendazole-7370 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null fluspirilene-6662 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null Organellar ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.348 HNF4A ChEA Transcription Factor Targets 1.0 null betaxolol-4608 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN012_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.14176 hsa-miR-4717-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Temsirolimus_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140056 Lung Neoplasms CTD Gene-Disease Associations 1.0 1.31985 nalidixic acid-2336 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4490 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4239 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22087 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046786 Lung squamous cell carcinoma_LUSC_TCGA-77-7463-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLHL12 Pathway Commons Protein-Protein Interactions 1.0 null corynanthine-4811 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCIH650 CCLE Cell Line Gene Expression Profiles -1.0 -1.87778 RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE48812_0_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null pyrophosphate-dependent phosphofructokinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.511 GSE226316_4_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1 Rummagene Transcription Factor Associations 2026 1.0 null CDC16 Pathway Commons Protein-Protein Interactions 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33848 Occipital lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.197 BRD-A02214146 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27431 9454_TXNIP_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.504338 posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.72402 GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles 1.0 1.41468 CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TUBB2A Pathway Commons Protein-Protein Interactions 1.0 null 6876_PSMD8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.507107 FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the ear HPO Gene-Disease Associations 1.0 null sulfinpyrazone-3192 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-92a TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 BRD-K69903198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49964 hsa-miR-216a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-1426-SM-46MUF GTEx Tissue Sample Gene Expression Profiles 1.0 0.955807 GP2D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.08845 GTEX-TKQ1-1026-SM-4GICL GTEx Tissue Sample Gene Expression Profiles 1.0 0.916488 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Decitabine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0139014 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147876,GSE147877_4_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Tentacle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.594 ATF3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K86937728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55109 A549_Valproic acid sodium salt_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0191052 15-delta prostaglandin J2-201 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.870154 PC-18-VX23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.235743 EP300_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FGFR3_knockdown_173_GSE41035 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 3.0448 CRCGN015_MCF10A_48H:F02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6502 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null adrenal gland GTEx Tissue Gene Expression Profiles 1.0 1.42527 GTEX-PX3G-2626-SM-2I3EG GTEx Tissue Sample Gene Expression Profiles 1.0 1.04892 BRD-K72807299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04073 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FUS Pathway Commons Protein-Protein Interactions 1.0 null tanespimycin-1206 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ChIP_ZFP281_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hearing abnormality HPO Gene-Disease Associations 1.0 null K562_Tie2 kinase inhibitor_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177317 hsa-miR-302c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE125219,GSE125221_4_v_0_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null GSE253795_1_v_0_alkbh5_human RummaGEO Gene Perturbation Signatures 1.0 null A549_JNJ-7706621_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0124963 a7r5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.779816 GTEX-VUSG-1526-SM-4KKZH GTEx Tissue Sample Gene Expression Profiles 1.0 1.27764 CL-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37216 ANAPC13 Pathway Commons Protein-Protein Interactions 1.0 null RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.9195 etodolac-7246 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K12612468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76754 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.44123 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.834704 KNS-42 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.94992 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.77646 MICOS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.985 RPL22 Pathway Commons Protein-Protein Interactions 1.0 null striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.66336 BRD-K28140029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79082 Perturb_14247_KO_FOXM1_SRP328179 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.34791 GSE193258,GSE193259_2_v_14_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE195568_2_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC4335056-pone.0116726.s005.xlsx-TX100_NOT_X-ChIP_QE-GENE_Official_symbol_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A112-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206516,GSE206518_5_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null KMS28BM CCLE Cell Line Gene CNV Profiles -1.0 -1.89009 NUDT1 Pathway Commons Protein-Protein Interactions 1.0 null PMC8260656-41467_2021_24380_MOESM4_ESM.xlsx-ERG_EZH2-ENHANCED_ERG Rummagene Transcription Factor Associations 2026 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.66465 GPI Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the genitourinary system HPO Gene-Disease Associations 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.42563 PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07631 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0526-SM-4DM56 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2643 Arnt MotifMap Predicted Transcription Factor Targets 1.0 null H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K24471810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27057 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84375 Bardet-Biedl syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.331 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.963356 acepromazine-6832 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null extracellular region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null SKHEP1_LIVER CCLE Cell Line Proteomics 1.0 2.05259 GSE233679_14_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null NR2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6227 SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14535 ITCH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03823 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12839 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null guanfacine-2634 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ATF3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7156-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17077 TCF3 ENCODE Transcription Factor Targets 1.0 null GSE158834_7_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null cell projection membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.798811 GSE135514_8_v_7_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEx Esophagus 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 15.2067 GTEX-T6MN-0426-SM-32PMF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881862 Acute Myeloid Leukemia_LAML_TCGA-AB-2871-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-POYW-0006-SM-2XCF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23173 GSE169152_3_v_1_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5581-01A-02R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Organellar small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.105 NEPHRONOPHTHISIS-LIKE NEPHROPATHY 1 CTD Gene-Disease Associations 1.0 2.88009 disulfiram-2053 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ATF3_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2185 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.30992 BRD-K90284572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46264 BRD-K06049932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13179 embryonic fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.080394 BRD-K99331869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20581 GSE134316_1_v_0_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92847 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5099-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null clorsulon-7264 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_9562_KO_Ogt_SRP110508 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.95576 H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K45519638 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4926 sknf1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.213 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.532314 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3ES-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K56149020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19813 Ciliary plasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.198 PMC10248509-Data_Sheet_5.CSV--GSE58294_DE-genes_AND_GSE66724_DE-Genes_AND_GSE41177_DE-Genes_NOT_Autophagy_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null Integral component of mitochondrial membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.129 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.58771 A549_Crizotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154728 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25583 GSE131649_4_v_10_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null BRD-K23923189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37273 GSE233679_14_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null glycopyrronium bromide-7386 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TNRC6B Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-6594-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_5_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Gandotinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0174196 BRD-K28108927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05485 GTEX-UJHI-1226-SM-4IHLR GTEx Tissue Sample Gene Expression Profiles 1.0 1.00732 BRD-K71109636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.2708 ChIP_DMAP1_20946988 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06314 5248896-838 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AG-06A-31R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Sorafenib Tosylate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159371 AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null Perturb_8398_KD_Safb_SRP180874 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.08218 MAX_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_8_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3712 cSARS Bat SRBD_60Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.19915 USF2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A28153253 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33091 CENPJ Pathway Commons Protein-Protein Interactions 1.0 null CELF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49413 BRD-K36804307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4246 GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.678614 CCT3 Pathway Commons Protein-Protein Interactions 1.0 null Pons TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.104 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chronic kidney disease HPO Gene-Disease Associations 1.0 null SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21059010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02952 BRD-K24035524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74791 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nimesulide-7024 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SELENOV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00109 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.959904 GSE179002_3_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SEC23A Pathway Commons Protein-Protein Interactions 1.0 null Tubular Basement Membrane Disintegration DisGeNET Gene-Phenotype Associations 1.0 null BRD-K12312755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89637 GTEX-W5X1-2826-SM-3GILM GTEx Tissue Sample Gene Expression Profiles 1.0 1.14363 benzbromarone-1291 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE154577_13_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.3619 BRD-K10876822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27959 SOX2_Deficiency_GDS4853_321_human_AZ-521 gastric cancer (GC) cell line - 18 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12356 GSE239844_7_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null Temporal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.993 GTEX-QDT8-0126-SM-48TZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.832656 A549_JQ1_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.00967164 BRD-K86630280 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35415 TRIM28 ENCODE Transcription Factor Targets 1.0 null GTEX-PWO3-0011-R6A-SM-2I5F3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06593 BRD-K40001806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11204 GSE158834_2_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.964846 CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.964077 inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.46247 glomerular filtration GO Biological Process Annotations 2023 1.0 null SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.64849 hsa-miR-3188 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null BRD-K56415410 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14437 KRT24 Pathway Commons Protein-Protein Interactions 1.0 null A549_UNC1999_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155938 GTEX-WL46-0011-R3A-SM-3TW8E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997201 prostate gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076062 RPS3 Pathway Commons Protein-Protein Interactions 1.0 null TOSEDOSTAT DGIdb Drug Targets 2026 1.0 2.78589 Brain Lower Grade Glioma_LGG_TCGA-S9-A7J3-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.925329 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.23793 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.34792 edrophonium chloride-6655 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-0011-R3A-SM-3P5ZM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.991139 BRD-K57938735 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06097 BRD-A00881124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6998 moxisylyte-1804 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MCF7_Trichostatin A_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00672463 NRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96170781 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94976 CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.889452 DNAJC10 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81253 central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06655 RPL38 Pathway Commons Protein-Protein Interactions 1.0 null Nephronophthisis 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.299 adipiodone-3111 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null WDR48 Pathway Commons Protein-Protein Interactions 1.0 null LRRC47 Pathway Commons Protein-Protein Interactions 1.0 null GSE134375_0_v_5_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null allantoin-1800 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null USF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83218047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38496 NFIC_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31271 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Pancreatic islet TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.175 Inflammation CTD Gene-Disease Associations 1.0 1.09083 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08549 BRD-K28656917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25916 GTEX-QEG4-1226-SM-2S1P6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843412 CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATG3 Pathway Commons Protein-Protein Interactions 1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADAMTS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54256 hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.87507 GSE105170,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures -1.0 null 6868_PSMD14_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.966593 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0726-SM-48TZP GTEx Tissue Sample Gene Expression Profiles 1.0 0.910854 TIA1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NR3C1_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null GSE169205_3_v_2_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48735 H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RNAi_-666_19345177 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 2393_DTX2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.524809 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.74959 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE76425_0_v_12_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_1_CTCF Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4755-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.447656 COCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.95979 GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 0.946005 hypophysis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.098647 KMS20 CCLE Cell Line Gene CNV Profiles -1.0 -1.43241 PMC10158025-ijbsv19p2081s6.xlsx-SupTable5-ZBTB20_ZBTB20 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K49050984 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11206 inferior frontal gyrus, orbital part, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05703 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TASK1 DepMap CRISPR Gene Dependency 1.0 2.27504 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-1246 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 Thylakoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.18 MCF7_Entinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00894538 PADI4-21655091-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BZW2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18442 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14535 testis_7a HPA Tissue Sample Gene Expression Profiles 1.0 1.52273 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null MT-ATP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01584 BRD-K11516621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03899 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100549_FWM_no dementia_TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16504 HOP-62 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.93358 MKX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04218 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YN-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K83270677 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10723 USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chloroquine-7251 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PDXK Pathway Commons Protein-Protein Interactions 1.0 null CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.21021 gallamine triethiodide-2059 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.732 UBA52 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_1_v_6_palm_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K74803017 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09489 abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.074889 monocrotaline-7127 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-11A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XAJ8-1126-SM-47JYA GTEx Tissue Sample Gene Expression Profiles 1.0 0.834696 GSE146982_4_v_6_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null Motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.11 6851_PSMB3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.570611 FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.902621 Frontotemporal dementia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.831423 TAF7L ChEA Transcription Factor Targets 1.0 null artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.116719 CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A19962819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20145 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null DCTN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72191 A549_Rucaparib_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0184481 TBP ENCODE Transcription Factor Targets 1.0 null TMBIM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12427 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Fulvestrant_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0178924 POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K80851151 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2709 anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11035 extracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BL7067 (IKBKB) NURSA Protein Complexes 1.0 null cation binding GO Molecular Function Annotations 2015 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -0.898539 HPAFII CCLE Cell Line Gene Expression Profiles -1.0 -1.99662 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null extracellular vesicular exosome GO Cellular Component Annotations 2015 1.0 null GSE120612_6_v_3_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null Hydrogenosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.066 BAG3 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S33H-1326-SM-4AD6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.34446 GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 3.52162 Lung squamous cell carcinoma_LUSC_TCGA-58-A46M-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH2004RT DepMap CRISPR Gene Dependency 1.0 2.15963 Nervous System Diseases CTD Gene-Disease Associations 1.0 1.38891 CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LU-139 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.40193 Formate dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.619 BRD-K66453893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38789 TUBA4A Pathway Commons Protein-Protein Interactions 1.0 null BRD-K61877191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20976 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null H4K91ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K62325456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50603 Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.154 i-AAA complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.035 A549_Streptozotocin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.01895 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.248 GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1043 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBM28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04611 GTEX-T5JC-2426-SM-3NMDB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09053 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831532 K562_Gandotinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176217 Brain Lower Grade Glioma_LGG_TCGA-DU-6393-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null N-acetylmuramic acid-3262 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A549_AG-14361_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0174963 Seizures CTD Gene-Disease Associations 1.0 1.19179 GSE246567_0_v_1_acat2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE233679_14_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 3-methylglutaconic aciduria type 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.603 Kidney failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.315 Fetal_Brain_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.10512 GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Selisistat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0226989 Intracellular ferritin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.536 ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05695 GSE158834_11_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18 Rummagene Transcription Factor Associations 2026 1.0 null PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34101 GA-28-SS67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03008 primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.977465 Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.6 DGAT2L7P Pathway Commons Protein-Protein Interactions 1.0 null Perturb_12768_KO_Cop1_SRP254109 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.34472 GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06606 GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles 1.0 0.892873 BRD-K27335290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05636 CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cloxacillin-1443 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-Q734-0126-SM-48U1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.48825 BRD-K91467861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16412 PMC11956947-media-4.xlsx-C_GSEA_gene_sets-TGAYRTCA_ATF3_Q6_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null S-isopropylisothiourea LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22846 Phosphomannomutase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.917 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 GAPVD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03581 GSE226249_5_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A0XA-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLNB Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-371-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.98367 RVH421 CCLE Cell Line Gene CNV Profiles 1.0 1.78422 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K45893504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19191 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null renal insufficiency HPO Gene-Disease Associations 1.0 null Photosystem II reaction center COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.043 GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24847 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HslUV protease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.353 hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.59994 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.6281 TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37701 Nrf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.1109 thiamazole-3815 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.7034 Nephronophthisis 19 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.989 GSE117730,GSE117732_0_v_1_apobec2_mouse RummaGEO Gene Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.24442 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMF1 Pathway Commons Protein-Protein Interactions 1.0 null A549_AZD1480_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149442 intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null tridihexethyl-3526 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null tubular atrophy HPO Gene-Disease Associations 1.0 null GTEX-P44H-0526-SM-2XCF1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.858188 Ciliopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.103 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52067 BRD-K81370109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4203 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K03602135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63861 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K71274071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53791 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.978165 BRD-K16705729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28989 vorinostat_homo sapiens_gpl6884_gse46703 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.72818 Vortioxetine_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0120814 CREB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59537 BCAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26416 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null acetylsalicylic acid-1204 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SAFB Pathway Commons Protein-Protein Interactions 1.0 null Chromosomal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.293 artemisinin-7247 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ERI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60162 Hippocampal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.536 BRD-K64939364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48698 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A06327019 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53685 GTEX-Q2AG-1126-SM-48U1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.32999 GTEX-OOBJ-2026-SM-3NB1R GTEx Tissue Sample Gene Expression Profiles 1.0 0.852477 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.663895 BRD-K56106571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.20286 GSE189859,GSE189861_4_v_2_idh1_human RummaGEO Gene Perturbation Signatures -1.0 null ATF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_UNC0631_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180624 Ellis-Van Creveld syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.189 GTEX-POYW-0826-SM-2XCEM GTEx Tissue Sample Gene Expression Profiles 1.0 1.60908 BRD-K68078571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88456 nephronophthisis-like nephropathy 1 OMIM Gene-Disease Associations 1.0 null BRD-K61912055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17476 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.66357 Ekl TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.616 GSE193258,GSE193259_2_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null norfloxacin-5985 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null nephropathy GeneRIF Biological Term Annotations 1.0 null FLI1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2758-01A-02R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K78676275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08659 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null smallintestine_4a HPA Tissue Sample Gene Expression Profiles -1.0 -0.934132 TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -3.85628 SKNAS CCLE Cell Line Gene CNV Profiles -1.0 -1.57508 L-cysteine desulfurase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.598 Chloroplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.518 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K84716908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45551 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K01512588 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34436 623 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.571 AHSA1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-1322 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 PMC4872073-supp_gkv1528_nar-02930-x-2015-File004.xlsx-Table_S2C-CREB1_FoxA1_Target_Genes_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.82 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18107 MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.328628 Sarcoma_SARC_TCGA-DX-A6YQ-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TOV112D Achilles Cell Line Gene Essentiality Profiles 1.0 1.10248 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2708-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW954 DepMap CRISPR Gene Dependency 1.0 2.94842 A549_Tofacitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150093 abnormality of the nephron HPO Gene-Disease Associations 1.0 null SKMEL28 CCLE Cell Line Gene CNV Profiles 1.0 1.61671 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null brush border membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.513677 BRD-K27035180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57953 PDCD6 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K34456337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70862 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.99419 CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE161064,GSE161065_0_v_1_kdm5b_mouse RummaGEO Gene Perturbation Signatures 1.0 null lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04371 chlortalidone-7152 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DENND6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20254 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sickle Cell Anemia_Endothelial cell_GSE9877 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.7242 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934258 BRD-K12120581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21182 imipenem-2873 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K38111331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03161 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DOK1 Pathway Commons Protein-Protein Interactions 1.0 null SARS-dORF6_60Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.96499 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02845 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null PC-62-AQ92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.97231 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.00955 CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.75154 RPS20 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.9825 PAX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7882 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09951 BRD-K30699866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6232 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE86507,GSE86509_4_v_8_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE244072_10_v_3_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null BRD-K05228434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18676 FOXK1 Pathway Commons Protein-Protein Interactions 1.0 null PMC6961462-NIHMS1544104-supplement-Sup_Tab.xlsx-Sup_Table_3_a-Supplementary_Table_3_Genes_Regulated_by_A_MYB_in_Humans_and_Macaques_Bold_genes_with_reduced_expression_in_Group_3_MYB Rummagene Transcription Factor Associations 2026 1.0 null K562_S3I-201_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180136 spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.936883 A549_Avagacestat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0128603 Cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.777 GSE146074_1_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Diseases, Cystic HuGE Navigator Gene-Phenotype Associations 1.0 null duodenum HPA Tissue Gene Expression Profiles -1.0 -2.05953 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IGR-37 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865243 GSE261563_2_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.615 VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null Specific developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.317 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OIZH-1326-SM-3NB1H GTEx Tissue Sample Gene Expression Profiles 1.0 1.23037 GSE193258,GSE193259_9_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE207611,GSE207612_3_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CA SKI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.847382 CAL-85-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSP90AB1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Glucose dbGAP Gene-Trait Associations 1.0 0.162486 A549_Belinostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0185242 PMC4090731-bjc2014262x1.xls-Sheet1-CaSig3-HSF1_Positive_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null butoconazole-6288 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.2636 PRKDC Pathway Commons Protein-Protein Interactions 1.0 null GSE199899_1_v_2_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Bronchial epithelial cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.688 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ChIP_MYCN_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SSBP1 Pathway Commons Protein-Protein Interactions 1.0 null Low density lipoprotein cholesterol levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.22218 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K92311828 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05561 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.105 USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09956 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4784-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null HCC202 CCLE Cell Line Gene Expression Profiles 1.0 2.99268 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72468 hsa-miR-378h TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 felodipine-2433 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TT-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP63 ChEA Transcription Factor Targets 1.0 null H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pellicular membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.802 Mitochondrion CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null CRCGN011_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.79725 BAG4 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K25646425 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17553 GSE199899_4_v_2_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null pimethixene-7426 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5525-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MCF7_Lenalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0202247 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN013_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.10909 PHGDH Pathway Commons Protein-Protein Interactions 1.0 null FASN Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-422a TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null zidovudine-5333 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Amyloidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.024 kidney_a HPA Tissue Sample Gene Expression Profiles 1.0 0.850355 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VM-CUB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.29834 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3660 TargetScan Predicted Conserved microRNA Targets 1.0 0.088999 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.942774 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12529 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKMEL30_SKIN CCLE Cell Line Proteomics 1.0 2.24093 GTEX-T5JC-0011-R5A-SM-32PLK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863565 BRD-K90092568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17035 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE66724_DE-Genes_NOT_Autophagy_NOT_GSE22255_DE-Genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865243 GTEX-U4B1-1926-SM-3DB9E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02859 SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.996143 SLC25A5 Pathway Commons Protein-Protein Interactions 1.0 null SIX5 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC70 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.50771 rosiglitazone-1174 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K96778009 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18589 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GM97 BioGPS Cell Line Gene Expression Profiles -1.0 -1.30744 Prostate adenocarcinoma_PRAD_TCGA-EJ-8469-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CUL9 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Mocetinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00924161 GSE214583,GSE214585_1_v_0_steap1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K50417536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0185 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cycloserine-3562 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SQSTM1 Pathway Commons Protein-Protein Interactions 1.0 null Amygdala TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.225 RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.2626 PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null EP300_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATG7 Pathway Commons Protein-Protein Interactions 1.0 null GSE242199_9_v_7_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null antimycin A-5472 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN014_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.84879 metampicillin-2123 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.926399 GSE115763_3_v_1_klf6_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4262 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCCSUP CCLE Cell Line Gene Expression Profiles -1.0 -2.40769 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05161 GSE138938_1_v_3_foxp2_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.992772 GSE169152_5_v_4_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.986352 MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.901712 A375_SKIN CCLE Cell Line Proteomics 1.0 2.22746 FOS ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E1-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.973612 vitexin-4588 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X3Y1-2426-SM-3P5Z7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13468 MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.966615 GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles 1.0 0.962106 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null renal cyst HPO Gene-Disease Associations 1.0 null CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane-bounded vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 ZNF14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34946 BRD-K28433349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80089 XPNPEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07829 A549_Altretamine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0169519 TOM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.782 GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.78527 H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EEF2 Pathway Commons Protein-Protein Interactions 1.0 null cos cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.189992 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03556 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52469 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09287 hsa-miR-520a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.95318 autosomal genetic disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206516,GSE206518_5_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.696681 BRD-K53889798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.3147 hippocampus (hippocampal formation)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.01536 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BUB3 Pathway Commons Protein-Protein Interactions 1.0 null USF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.273734 hsa-miR-4288 TargetScan Predicted Conserved microRNA Targets 1.0 0.053794 YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K32702774 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07115 GSE205332_1_v_0_queuine_human RummaGEO Drug Perturbation Signatures -1.0 null SPC24 Pathway Commons Protein-Protein Interactions 1.0 null Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.104 cas1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.653 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.42458 hsa-miR-524-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 BRD-K65488906 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24695 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.52329 Glandular stomach TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.714 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054849 desoxycortone-6758 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE202434,GSE202438_10_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null HSPA4 Pathway Commons Protein-Protein Interactions 1.0 null Autosomal dominant polycystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.416 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IALM CCLE Cell Line Gene Expression Profiles -1.0 -2.31219 GSE233679_5_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null TMEM216 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66677 yy2_20215434_hela_lof_human_gpl570_gds3788 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.114171 EWSR1 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03556 GTEX-WY7C-2626-SM-3NB2P GTEx Tissue Sample Gene Expression Profiles 1.0 0.85034 GTEX-S7SF-0226-SM-3K2BI GTEx Tissue Sample Gene Expression Profiles 1.0 0.832401 FLG2 Pathway Commons Protein-Protein Interactions 1.0 null nephronophthisislike GeneRIF Biological Term Annotations 1.0 null TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K93663012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1095 Poisoning CTD Gene-Disease Associations 1.0 1.08126 hsa-miR-520d-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 RFX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4198 GSE158834_1_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM Rummagene Transcription Factor Associations 2026 1.0 null ChIP_KLF4_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SA-31-VB03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.611478 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35547 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-302d TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_TG101209_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0119704 protein processing GO Biological Process Annotations 2023 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-1622-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05222 primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.930897 SETDB1 ENCODE Transcription Factor Targets 1.0 null Hereditary ataxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.355 CRCGN017_MCF10A.WT.HP_24H:P11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2087 GSE173201_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09102 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K42966513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85109 CE-15-YU05_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.405838 NCIH146_LUNG CCLE Cell Line Proteomics 1.0 6.6225 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.925329 BRD-K68970089 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.4463 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cobalt HMDB Metabolites of Enzymes 1.0 null GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830157 SP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23751 1840_CPSF2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.710054 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K80414383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63625 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PHB2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WL46-2926-SM-3LK82 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.984187 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE174383_2_v_7_ly6d_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null blood vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.08744 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.952382 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42P-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-765 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE168798_0_v_1_isg15_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K97977764 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01873 GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50869 Lung squamous cell carcinoma_LUSC_TCGA-56-7580-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UJHI-0006-SM-3DB8H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945136 U2OS DepMap CRISPR Gene Dependency 1.0 3.86832 stage 5 chronic kidney disease HPO Gene-Disease Associations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EQ-01A-21R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hereditary spastic paraplegia 9A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.236332 Meprin A complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.023 ECC10 CCLE Cell Line Gene Expression Profiles -1.0 -1.68592 IRX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45321 abnormality of the nervous system HPO Gene-Disease Associations 1.0 null cyclic adenosine monophosphate-3531 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amikacin-6715 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EXO1 Pathway Commons Protein-Protein Interactions 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.85069 ANAPC2 Pathway Commons Protein-Protein Interactions 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.91265 BRD-K32431589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17477 K562_Cediranib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0183298 aorta thoracica TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.205543 etiocholanolone-4298 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE142210_4_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EL-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21637 PMC4332150-msb0011-0775-sd13.xlsx-JUN-Prey_Gene_Symbol_JUN Rummagene Transcription Factor Associations 2026 1.0 null A549_WHI-P154_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176807 GTEX-OXRK-0126-SM-3NB1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.60761 M059J Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02708 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SMARCAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17038 GSE212299_2_v_1_abi3_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Entacapone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0126407 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null clozapine-4453 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06844 roxithromycin-3331 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.782285 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169155_6_v_0_acetaminophen_mouse RummaGEO Drug Perturbation Signatures -1.0 null Mitochondrial small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.106 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null autosomal recessive disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null Neostriatum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.083 metacetamol LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85534 CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null CF-91-JY05_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221439 Brain Lower Grade Glioma_LGG_TCGA-VV-A829-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.45884 A549_AICAR_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0169043 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN011_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0607 CRCGN017_MCF10A.WT.HP_24H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.16295 SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE220914_2_v_0_zdhhc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Foxn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.5883 POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02947 Polycystic Ovary Syndrome_Skeletal muscle_GSE6798 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.47792 GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21425 KRT13 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-4422 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cystic Kidney DisGeNET Gene-Disease Associations 1.0 null GSE140997_4_v_1_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null acetazolamide-1850 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A549_WP1066_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015862 ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.45495 GTEX-U3ZH-1626-SM-3DB74 GTEx Tissue Sample Gene Expression Profiles 1.0 0.873517 renal filtration GO Biological Process Annotations 2015 1.0 null A549_Nintedanib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0300886 FOXM1 ENCODE Transcription Factor Targets 1.0 null GTEX-S341-1926-SM-3K2BA GTEx Tissue Sample Gene Expression Profiles 1.0 0.91884 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.63862 CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94582731 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49436 BRD-K25465939 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46178 ACC3 BioGPS Cell Line Gene Expression Profiles -1.0 -1.20995 GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03723 Depressive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.512 BRD-K02972160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99299 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859131 GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49427 adenohypophysis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.172504 Renal Corticomedullary Cysts DisGeNET Gene-Disease Associations 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Synucleinopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.255 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE86507,GSE86509_0_v_8_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null FADU CCLE Cell Line Gene CNV Profiles 1.0 1.67107 Chronic progressive external ophthalmoplegia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.355 MAD2L1 Pathway Commons Protein-Protein Interactions 1.0 null Cranioectodermal dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.693 BE-13 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.52684 GSE163862_0_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE166920_6_v_5_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-373 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 BRD-K09373762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.95822 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-IE-A4EK-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null natamycin-6126 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null K562_AZD1480_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184027 BRD-K08409548 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14276 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.5777 DDX17 Pathway Commons Protein-Protein Interactions 1.0 null LN-229 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36059 ACSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06672 HSF1-23293686-STHDH_STRIATAL-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Golgi transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.198 C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.03386 Lung squamous cell carcinoma_LUSC_TCGA-43-6770-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GB-73-QS80_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.361142 Hypodermal seam cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.738 extracellular vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GSE178255_1_v_4_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primaquine-3279 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 496100516_FWM_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.46284 GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05228 GSE217526_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K97157596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40484 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null triflupromazine-1691 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MEIS1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-548d-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 CRCGN011_HEPG2_24H:E11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1523 Cerebellar ataxia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.367 XD-44-FJ34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.561014 decreased grip strength MGI Mouse Phenotype Associations 2023 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.14302 MIS12 Pathway Commons Protein-Protein Interactions 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the renal cortex HPO Gene-Disease Associations 1.0 null genistein-1235 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Congenital Abnormalities CTD Gene-Disease Associations 1.0 1.24244 USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE192513,GSE192515_1_v_0_atg16l1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-POYW-0426-SM-2XCEV GTEx Tissue Sample Gene Expression Profiles 1.0 1.42822 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_EED226_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209798 GSE188458_2_v_4_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Creatinase/Aminopeptidase P/Spt16, N-terminal InterPro Predicted Protein Domain Annotations 1.0 null BRD-K11016405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04677 BC-61-BE07_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.412077 USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEx Brain 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures 1.0 15.8015 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07002 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K79529972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05442 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2218 CCLE Cell Line Gene Expression Profiles 1.0 1.8897 FXR MotifMap Predicted Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2821-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68675 Cytotoxic T-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.322 single-multicellular organism process GO Biological Process Annotations 2015 1.0 null CB-31-UO16_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.286705 BRD-K14399036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37275 ELK1 ENCODE Transcription Factor Targets 1.0 null Chronic Kidney Disease DisGeNET Gene-Disease Associations 1.0 null ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13998 GSE205687_1_v_0_mta1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K91624805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30763 BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.20393 NB17 DepMap CRISPR Gene Dependency 1.0 2.99599 IM-95 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-95-7043-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VDAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67639 hsa-miR-3925-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 DLD1 BioGPS Cell Line Gene Expression Profiles 1.0 1.15622 hippocampus (hippocampal formation)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.963731 A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.65251 GGH Pathway Commons Protein-Protein Interactions 1.0 null HSPA1L Pathway Commons Protein-Protein Interactions 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TIM23 mitochondrial import inner membrane translocase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.914 BRD-K67126097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39853 tolazoline-4844 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null vacuole LOCATE Predicted Protein Localization Annotations 1.0 null substantia nigra, pars reticulata, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.84007 Inflorescence meristem TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.855 intracellular part GO Cellular Component Annotations 2015 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8323-01A-21R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null protein processing GO Biological Process Annotations 2025 1.0 null GTEX-OOBJ-0326-SM-33HBO GTEx Tissue Sample Gene Expression Profiles 1.0 0.969197 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Spleen TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.292 CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09681 rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.965165 BRD-K00263786 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70018 A549_Temsirolimus_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0199825 H3K4ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZFP281-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K59893572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51931 GSE217452_3_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null protein homodimerization activity GO Molecular Function Annotations 2025 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tubular Atrophy Assessment DisGeNET Gene-Phenotype Associations 1.0 null develop GeneRIF Biological Term Annotations 1.0 null CRCGN015_MCF10A.WT.HP_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07432 Hyperkinesis CTD Gene-Disease Associations 1.0 1.03827 TCEB2 Pathway Commons Protein-Protein Interactions 1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE121824,GSE121826_0_v_6_scaf8_human RummaGEO Gene Perturbation Signatures -1.0 null HCT-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.968678 mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 LB771HNC DepMap CRISPR Gene Dependency 1.0 8.30824 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null WFS1 Pathway Commons Protein-Protein Interactions 1.0 null metalloaminopeptidase activity GO Molecular Function Annotations 2025 1.0 null hsa-miR-194 TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 496100416_FWM_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21001 GTEX-S3XE-0326-SM-4AD6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00615 Cognition Disorders CTD Gene-Disease Associations 1.0 1.43266 GSE154577_6_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF549 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.5446 CDC27 Pathway Commons Protein-Protein Interactions 1.0 null SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ZNF281 ChEA Transcription Factor Targets 1.0 null BRD-K08534346 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34715 SRF_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06965 Essential tremor DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.051 Spondylometaphyseal dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.162 PMC10882188-ADB-29-e13365-s002.xlsx-ST18-Unnamed_8_ST18 Rummagene Transcription Factor Associations 2026 1.0 null isocarboxazid-7383 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-4715-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.09606 CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 SW 1463 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.925329 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cell envelope Sec protein transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.565 CRCGN016_MCF10A.WT.HP_24H:P11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.775 CRCGN017_MCF10A.WT.HP_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.06355 HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2860-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFG8-2226-SM-3GIL9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16278 HNRNPAB Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7873-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perrault syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.7 UBTF ENCODE Transcription Factor Targets 1.0 null Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15666 SK-N-AS COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-31 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 SW579 DepMap CRISPR Gene Dependency 1.0 2.01368 hydrastinine-2283 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 3.2156 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Lomustine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166659 hsa-miR-548h TargetScan Predicted Conserved microRNA Targets 1.0 0.632343 GSE199660_1_v_0_secretin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.243 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null GSE235945_1_v_0_pikfyve_mouse RummaGEO Gene Perturbation Signatures 1.0 null MDAPCA2B CCLE Cell Line Gene Expression Profiles 1.0 1.37301 RELA_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGW Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.0489 BRD-K31820800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35021 0198306-0000-7069 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05791 Prestwick-1084-3546 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZNF384_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1573 COSMIC Cell Line Gene Mutation Profiles 1.0 null MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.980096 renal filtration GO Biological Process Annotations 2023 1.0 null hsa-miR-4320 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 hsa-miR-4507 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 K562 BioGPS Cell Line Gene Expression Profiles -1.0 -1.23514 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71A-01A-22R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intrinsic component of mitochondrial membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.005 BRD-K11188962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39652 POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EWSR1_02_122 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59982 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.980251 lysosome LOCATE Predicted Protein Localization Annotations 1.0 null Apolipoprotein B levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.809691 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.027587 rectum HPA Tissue Protein Expression Profiles 1.0 0.703068 hsa-miR-1286 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 solasodine-4305 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null urinary system disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null BRD-K63997411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92505 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SP-01B-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_3_AP1_Up_JUN Rummagene Transcription Factor Associations 2026 1.0 null CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K11846531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53194 MDA MB435 BioGPS Cell Line Gene Expression Profiles -1.0 -1.15927 NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 3479_GOSR2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.16502 BRD-K77490065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16887 GTEX-OIZG-0426-SM-3LK5W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01518 postcentral gyrus, right, bank of the posterior central sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.945023 ZFP42 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2369 ZNF669 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.045 GTEX-O5YV-1126-SM-3LK73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33975 GSE228106_0_v_4_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null MYCN-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06301 B-lymphoblastoid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.852 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76646 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null adrenal medulla TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.198386 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.31925 mitochondrion GO Cellular Component Annotations 2015 1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null buspirone-2637 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XQ8I-0726-SM-4BOPU GTEx Tissue Sample Gene Expression Profiles 1.0 0.999182 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896416 CRCGN015_HEPG2_48H:B21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07519 GSE167218_1_v_0_hoxd12_mouse RummaGEO Gene Perturbation Signatures -1.0 null SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5M9-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K24178822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52249 TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MIM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.069 GSE240386,GSE242143_1_v_5_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null securinine-6831 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.18 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Calyx TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.732 H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970579 MCF7_Busulfan_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140175 RANBP2 Pathway Commons Protein-Protein Interactions 1.0 null Slime layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.613 ATF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_PCI-34051_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0188644 GSE199899_1_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE178532_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.70727 MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64216 H3K9ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.92369 CRCGN011_HEPG2_24H:B13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.12295 PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.870739 BRD-A19829191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0864 CHD1 ENCODE Transcription Factor Targets 1.0 null MYC-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06954 H3K27ac_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HSF1 ENCODE Transcription Factor Targets 1.0 null BRD-K59821372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6906 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON Rummagene Transcription Factor Associations 2026 1.0 null FYCO1 Pathway Commons Protein-Protein Interactions 1.0 null Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 E2F6 ENCODE Transcription Factor Targets 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.831846 KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20467 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.95214 H2BK12ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K77108448 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03813 K562_Ellagic acid_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184904 breast HPA Tissue Protein Expression Profiles -1.0 -0.812903 MALME 3M BioGPS Cell Line Gene Expression Profiles -1.0 -1.555 H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.97858 HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.849175 pramocaine-3811 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-5125-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZY-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Belinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00822729 EP300_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transition metal ion binding GO Molecular Function Annotations 2023 1.0 null RALBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13723 GTEX-RM2N-0126-SM-48FDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.11486 striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.41923 aorta cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.668843 cyclopenthiazide-4229 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8335-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TYKNU Achilles Cell Line Gene Essentiality Profiles 1.0 1.29476 TRIM21 Pathway Commons Protein-Protein Interactions 1.0 null AC-84-QG99_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.246084 A549_Anacardic Acid_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146169 KP1NL Achilles Cell Line Gene Essentiality Profiles -1.0 -1.31949 GSE224294_1_v_2_ngly1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U4B1-0226-SM-4DXU8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.848686 PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S2-HSF1_CanSig_Genes-HSF1-CanSig_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null gamma-secretase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.534 BRD-K69337311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.31183 NCL Pathway Commons Protein-Protein Interactions 1.0 null CRCGN011_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7937 GTEX-OHPM-0426-SM-3TW8V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0967 BRD-K48863591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55289 embryonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.083254 HPAF-II Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.43801 proteolysis GO Biological Process Annotations 2025 1.0 null TAF7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANAPC16 Pathway Commons Protein-Protein Interactions 1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tauopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.688 BRD-K72717797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33508 proton-transporting two-sector ATPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.014 EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dementia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.532 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A549_Zileuton_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0198834 CRCGN015_MCF10A.TP53.M_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0553 BRD-K38917645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01291 small intestine HPA Tissue Gene Expression Profiles -1.0 -1.11765 GTEX-U3ZM-0226-SM-4DXTA GTEx Tissue Sample Gene Expression Profiles 1.0 1.02358 GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4406 PRDX3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K85234739 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55535 Hereditary spastic paraplegia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 HUPT3 CCLE Cell Line Gene CNV Profiles -1.0 -1.35068 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23281 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UH-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41002 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cyanelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.778 Clitoral gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.729 BRD-K34980742 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7093 MCF7_Andarine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0186493 GATA1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KALS-1 COSMIC Cell Line Gene CNV Profiles -1.0 -3.2703 hsa-miR-3189-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 TD-69-UA90_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236502 POU2F2 ENCODE Transcription Factor Targets 1.0 null PPIA Pathway Commons Protein-Protein Interactions 1.0 null BRD-K37253893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07041 Plasma membrane-derived chromatophore membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.528 transition metal ion binding GO Molecular Function Annotations 2025 1.0 null Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.254 BRD-K33287655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98439 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RD-01A-12R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60069390 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.27918 PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K16598630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42021 TUHR14TKB CCLE Cell Line Gene Expression Profiles 1.0 1.68468 HUWE1 Pathway Commons Protein-Protein Interactions 1.0 null PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null HSF1 ChEA Transcription Factor Targets 1.0 null G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26608 dorsolateral prefrontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06824 BRD-A07870296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02646 RYK Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null extracellular organelle GO Cellular Component Annotations 2015 1.0 null hsa-miR-3673 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 BRD-K38831170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24098 LN-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H1048 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.54808 VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63616 POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Mitochondrial metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.368 GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03876 GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures -1.0 null GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:H04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4975 CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A45349889 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71529 flunisolide-4303 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K10288935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76647 CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.303364 pancreatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.201962 PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.920444 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5KH-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.67588 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.768 metrifonate-1797 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.163 USF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein maturation GO Biological Process Annotations 2025 1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36059 GSE228894_0_v_1_rnmt_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN011_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.49045 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 autosomal recessive inheritance HPO Gene-Disease Associations 1.0 null CRCGN017_MCF10A.WT.HP_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19405 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.31161 CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null testis_7f HPA Tissue Sample Gene Expression Profiles 1.0 1.38421 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051136 aorta thoracica smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.264524 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.53983 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K90325960 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97283 RUVBL2 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-T7-A92I-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.15338 KYSE180 DepMap CRISPR Gene Dependency 1.0 5.5309 TAL1 ENCODE Transcription Factor Targets 1.0 null posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13003 K562_AMG-900_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144841 SPTBN1 Pathway Commons Protein-Protein Interactions 1.0 null dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.861601 RBBP5 ENCODE Transcription Factor Targets 1.0 null PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null TCFCP2L1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-O2-A52N-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null QE-48-NG07_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223144 apomorphine-2005 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4721 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 delsoline-7212 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38917 CRCGN012_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.66396 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3064-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.632343 T3M10 CCLE Cell Line Gene CNV Profiles -1.0 -1.66635 RPLP1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3853418-1756-8935-6-34-S3.pdf-23-MNT_MNT Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 1.53102 JHOM2B CCLE Cell Line Gene CNV Profiles -1.0 -1.46142 NCBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51384 napelline-6084 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SRF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.9739 morantel-7010 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FAM91A1 Pathway Commons Protein-Protein Interactions 1.0 null CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7788-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K59747214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42267 GSE193258,GSE193259_5_v_14_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.74618 CRCGN014_HEPG2_3H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.59005 aortic smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.194246 OE-89-FS84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283662 CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S341-0126-SM-4AD64 GTEx Tissue Sample Gene Expression Profiles 1.0 0.89264 IARS Pathway Commons Protein-Protein Interactions 1.0 null nocodazole-6793 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K35386584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25676 HNRNPL Pathway Commons Protein-Protein Interactions 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K14166090 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55406 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TARS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00113 Photosystem II COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.928 benfotiamine-4312 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null naftidrofuryl-2622 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null C32 CCLE Cell Line Gene CNV Profiles 1.0 1.3432 GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00243 KRT1 Pathway Commons Protein-Protein Interactions 1.0 null GSE214596,GSE214598_1_v_2_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null POU1F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3102 PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null DNAJA2 Pathway Commons Protein-Protein Interactions 1.0 null cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13901 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.56939 Bacterial thylakoid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.553 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7201 GTEX-XOT4-0326-SM-4B66S GTEx Tissue Sample Gene Expression Profiles 1.0 1.26392 BHLHE40_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 1.91229 MCF7_Thiotepa_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.013914 Nephronophthisis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.61 A549_JQ1_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0124866 GTEX-XQ3S-1726-SM-4BOOD GTEx Tissue Sample Gene Expression Profiles 1.0 1.4003 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.048266 Sarcoma_SARC_TCGA-QQ-A5V9-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HGC27 CCLE Cell Line Gene Expression Profiles 1.0 1.36078 lateral group of nuclei, right, ventral division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.949075 iodixanol-3023 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE242199_9_v_5_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE76425_0_v_5_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null outer CP in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03246 BRD-K81956993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.35331 A549_Dacinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0182069 hsa-miR-4487 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC4335056-pone.0116726.s005.xlsx-Biol_2_QE_NOT_FT-GENE_Official_symbol_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null Digestive cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.778 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribavirin_homo sapiens_gpl570_gds4391 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KPL1 DepMap CRISPR Gene Dependency 1.0 6.20436 Tonsil TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.304 1177_CAPG_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.588656 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K39078753 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30708 GP5D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.51019 H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE178714_1_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Nucleolus organizer region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.028 GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 BRD-K07383982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02983 BRD-K25075258 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08631 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-378c TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 bupivacaine-5537 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K47988839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84548 TNFRSF1B Pathway Commons Protein-Protein Interactions 1.0 null RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.865865 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.88839 GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.42512 mc2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.584 abnormality of the abdominal organs HPO Gene-Disease Associations 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K85161353 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60473 Thalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.386 PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-SYMBOL_DBP Rummagene Transcription Factor Associations 2026 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.19387 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EP-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928834 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null extracellular region part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K21036759 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24809 Brain Lower Grade Glioma_LGG_TCGA-DU-6400-01A-12R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acetolactate synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.772 GSE119498_0_v_10_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null soft tissue HPA Tissue Protein Expression Profiles -1.0 -0.738602 Hematopoietic cell line TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 BRD-A48913311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67127 hydrolase activity GO Molecular Function Annotations 2015 1.0 null JR DepMap CRISPR Gene Dependency 1.0 3.20281 BRD-K45984211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1757 A549_ENMD-2076_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0125958 MCF7_Alisertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0128149 H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Plastid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.554 Lung squamous cell carcinoma_LUSC_TCGA-77-6845-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15465 PARN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0544 COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25183 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Charcot-Marie-Tooth disease X-linked recessive 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 Mitochondrial processing peptidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.351 inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00426 GTEX-N7MT-0007-SM-3GACQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959563 A549_JNJ-26854165_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158757 inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40695 hsa-miR-4763-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CREB1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCCSUP Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -5.09452 cetuximab_homo sapiens_gpl570_gse21483 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Erythroid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 2.214 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K60932633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3289 hydrocortisone-5284 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE227698_2_v_4_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null Medulla oblongata TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.151 HCLS1 Pathway Commons Protein-Protein Interactions 1.0 null ALB Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null pancreas disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.077578 abnormality of the renal medulla HPO Gene-Disease Associations 1.0 null cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.90415 KDM6A ChEA Transcription Factor Targets 1.0 null Joubert syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.901 GSE158834_1_v_5_palm_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02723 SNRPE Pathway Commons Protein-Protein Interactions 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null SRF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.569 Liver Diseases CTD Gene-Disease Associations 1.0 1.26359 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.57589 TCFCP2L1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null appendix HPA Tissue Protein Expression Profiles 1.0 0.703068 hsa-miR-544b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE125219,GSE125221_3_v_0_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A8YO-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.37527 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AU565 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.47731 brush border COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.37045 primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.870429 clioquinol-6461 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C-reactive protein levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.8 FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 82.0362 SRF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100640_PCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.43221 Floral meristem TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.925 reticular nucleus of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31093 SPI1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YV-0006-SM-2I5GX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28068 GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.860804 GSE199606_6_v_4_csf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K54134201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43343 BRD-K44339278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18441 7754_SEC62_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.596636 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064935 BRD-K32018176 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58618 PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1659 HNRNPDL Pathway Commons Protein-Protein Interactions 1.0 null GSE201309_4_v_8_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null ZBTB33 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7121 GSE217452_3_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PTPN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12473 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.028476 Experiencing mood swings GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.969897 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CARM1 Pathway Commons Protein-Protein Interactions 1.0 null GSE133505_5_v_4_myf6_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5758 Barth syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.249 Abiraterone acetate_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0107436 SF268 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11582 K562_Glesatinib(MGCD265)_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145443 X-linked monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 isoflupredone-1873 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_7216_KD_EZH2_SRP321650 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.60981 Sarcoma_SARC_TCGA-FX-A2QS-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A118-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SR-95531-3253 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null nucleus LOCATE Predicted Protein Localization Annotations 1.0 null ramipril-3572 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-1226-SM-3NMA5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34427 SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37668 BFTC909 CCLE Cell Line Gene Expression Profiles 1.0 1.56533 microvillus membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.910647 Cingulate gyrus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.272 CDC20 Pathway Commons Protein-Protein Interactions 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A821-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-532-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.962546 A549_Curcumin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0213306 ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.881797 RPL8 Pathway Commons Protein-Protein Interactions 1.0 null liothyronine-4947 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Alzheimer's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.693 HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.15508 BRD-K64730221 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35932 multicellular organismal process GO Biological Process Annotations 2015 1.0 null aorta thoracica smooth muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.669657 MYC_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3t3-l1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.231482 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.69247 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null alcuronium chloride-7345 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE171837_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null protein metabolic process GO Biological Process Annotations 2015 1.0 null A549_Sirtinol_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167284 POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.21 abnormality of the upper urinary tract HPO Gene-Disease Associations 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1761 USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_PF-573228_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160454 CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.91376 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYCN-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null A-CA-04-2009(H1N1)_48Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.52574 GTEX-O5YT-0126-SM-48TBW GTEx Tissue Sample Gene Expression Profiles 1.0 0.928847 MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1293 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE147876,GSE147877_4_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null JA-23-QE71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.436098 hsa-miR-3978 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 proteolysis GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8073-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 2.88682 Brain Lower Grade Glioma_LGG_TCGA-HT-7469-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95334975 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19476 GSE199606_1_v_4_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:P08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4385 increased body weight GWASdb SNP-Phenotype Associations 1.0 0.696681 HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K01296372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21612 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE150895,GSE150896_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CC-03-PW00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.386317 Autosomal genetic disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.786 A549_ITSA-1_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0147067 Bark TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.752 6-bromoindirubin-3'-oxime-7101 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAP1B Pathway Commons Protein-Protein Interactions 1.0 null PMC5452392-13058_2017_854_MOESM3_ESM.xlsx-Table_S7-Variants_within_GWAS_blocks_control_MAF_0_01_case_MAF_control_MAF_within_gwas_breast_cancer_regions_deleteious_score_0_5_MAF Rummagene Transcription Factor Associations 2026 1.0 null Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.213 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.865267 GSE130246_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null HCC202 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.40316 PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.870154 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13941 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 821_BET1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.06337 SB-203580-7066 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MEIS1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null SKMEL2 CCLE Cell Line Gene CNV Profiles 1.0 3.27357 A549_SB431542_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014031 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.75803 ikarugamycin-866 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER ChEA Transcription Factor Targets 2022 1.0 null BRD-K21927299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.17381 Tassel TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.512 DHX9 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.93 CLINT1 Pathway Commons Protein-Protein Interactions 1.0 null FOXI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34088 BUB1B Pathway Commons Protein-Protein Interactions 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1944 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.82873 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE169205_0_v_6_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null Acute lymphoblastic leukemia cell line TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.05045 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064468 ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20834 naftifine-7032 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08533 NCIH2228 CCLE Cell Line Gene CNV Profiles -1.0 -1.5782 sclc21h HPA Cell Line Gene Expression Profiles -1.0 -1.01722 A549_Vandetanib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.017263 BRD-K43911180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36575 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39682 MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null senior-loken syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.50272 GTEX-W5X1-0426-SM-3GILB GTEx Tissue Sample Gene Expression Profiles 1.0 1.23178 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23765 Psychotic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.102 SUP-HD1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.4091 MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4645-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.474009 POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoblastic leukemia cell line TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 3054_FECH_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.592967 BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFG Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T6MN-0626-SM-32PM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06762 GTEx Esophagus 20-29 vs 40-49 GTEx Tissue-Specific Aging Signatures 1.0 4.94578 GSE199899_3_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K78615842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61046 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.15465 CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.76282 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19C-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null k562 HPA Cell Line Gene Expression Profiles 1.0 1.46455 ASAH1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null vascular smooth muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.656242 BRD-K75529374 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03903 PPARGC1A ENCODE Transcription Factor Targets 1.0 null Lung TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 hsa-miR-4330 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 BRD-K97493608 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06043 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JC-02-ZR15_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377791 blood vessel GTEx Tissue Gene Expression Profiles -1.0 -0.898748 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.92301 GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.89073 SLC25A6 Pathway Commons Protein-Protein Interactions 1.0 null outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42352 Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.117 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.385 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.939926 K562_Bisindolylmaleimide IX_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0164873 PPP1CC Pathway Commons Protein-Protein Interactions 1.0 null SLC39A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48836 GTEX-QMRM-0626-SM-447BQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896927 PMC10967149-12903_2024_4167_MOESM3_ESM.xlsx-LPS_VS_LPS_PDLSC-CM_776-Gene_symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61144 FOSL2 ENCODE Transcription Factor Targets 1.0 null SK-N-SH Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.95693 DDX3X Pathway Commons Protein-Protein Interactions 1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.91265 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-XQ3S-0126-SM-4BOO9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872801 BRD-A47137250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60075 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE114013,GSE114014_0_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WRHK-1726-SM-3MJFK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824221 dyclonine-7022 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null arl6 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.243 Spinal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.654 fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 1.17487 BRD-K56125296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76902 GA-28-SS67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.677609 Globus pallidus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.021 Combined oxidative phosphorylation deficiency 31 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.139 GSE213588_9_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10852 ACTB Pathway Commons Protein-Protein Interactions 1.0 null SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Rucaparib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159649 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.084594 ANAPC7 Pathway Commons Protein-Protein Interactions 1.0 null gabexate-2937 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Situs inversus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.492 abnormal auditory brainstem response MGI Mouse Phenotype Associations 2023 1.0 null PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3 Rummagene Transcription Factor Associations 2026 1.0 null A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08643 hippocampus HPA Tissue Protein Expression Profiles -1.0 -0.968536 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null NPM1 Pathway Commons Protein-Protein Interactions 1.0 null Mitochondrial DNA depletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.223 NCI-N87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20871 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYBL2 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4723-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREM ChEA Transcription Factor Targets 1.0 null NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25033 BRD-K51157416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05466 etodolac-1407 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null testis_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.01052 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.40903 BRD-A20463452 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08631 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.715 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TMMY-1026-SM-4DXTI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03871 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.837268 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ZNF524 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.062 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.46586 Cerebrovascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.003 SAFB2 Pathway Commons Protein-Protein Interactions 1.0 null JEG-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.196 GSE153484_2_v_0_foxp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96549574 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14646 BRD-K32208085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07965 BC-21-EB65_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210706 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fenspiride-2106 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.56284 Rectum adenocarcinoma_READ_TCGA-AG-3902-01A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GF-05-GQ05_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.379574 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0763 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.66925 BRD-K43240808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8767 Bone marrow TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.317 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Avian pallium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.225 ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40869 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.879954 BRD-K17405621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.53841 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_increase_in_MLL-AF4_ChIP-seq_signal_371_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.92651 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SB-228357 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06296 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A631-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Gandotinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163545 GSE242199_6_v_7_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K79627231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0054 inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12961 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TJP3 Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PU-01A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31011 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:J12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07825 BRD-K88369626 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44502 HCC2935 CCLE Cell Line Gene Expression Profiles 1.0 2.25193 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26512 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Y-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199092_2_v_0_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147876,GSE147877_4_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.71038 KYSE-50 COSMIC Cell Line Gene Mutation Profiles 1.0 null TBXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06882 Perturb_8356_KO_HKDC1_SRP346010 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20426 POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null spectinomycin-2987 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A549_Curcumin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0196449 GSE154081_3_v_0_sildenafil_mouse RummaGEO Drug Perturbation Signatures 1.0 null Amino acid metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.014 T3M4 CCLE Cell Line Gene CNV Profiles 1.0 1.65042 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MCF7_JNJ-7706621_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0149143 ketoprofen-3729 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE214442_0_v_1_pak4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE199899_4_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-4760-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5933_OGT_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.868577 SF295 Achilles Cell Line Gene Essentiality Profiles 1.0 1.90516 AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.835493 TRAP1 Pathway Commons Protein-Protein Interactions 1.0 null fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.074334 nimodipine-3103 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K41946683 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00657 5919_STN1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.0214 POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A79884839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75148 diclofenac-333 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null Pervasive developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 Bronchial epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.688 cefadroxil-1323 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.864169 GSE158815_1_v_3_trib1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC7A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38527 Necrosis CTD Gene-Disease Associations 1.0 1.44139 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null OAW42 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1626 Lung adenocarcinoma_LUAD_TCGA-97-8174-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RXRA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.84399 Respiratory epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.688 BRD-K51054674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19802 SIRT6 ENCODE Transcription Factor Targets 1.0 null excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.574416 WM1799_SKIN CCLE Cell Line Proteomics 1.0 2.34891 MCF7_Clevudine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0217584 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1226 TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 FA-63-WI26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.207122 sulfacetamide-1817 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K58323923 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7771 BRD-K35429158 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.13402 all GWASdb SNP-Phenotype Associations 1.0 0.036503 GSE77108_0_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN011_HEPG2_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.33275 GSE158834_12_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE86507,GSE86509_7_v_8_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null hsa-miR-181a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -3.14221 A549_FLLL32_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0143888 GTEX-NPJ8-0011-R8a-SM-2HMLG GTEx Tissue Sample Gene Expression Profiles 1.0 0.854053 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE199092_1_v_0_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K24554824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76383 amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20233 EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.329772 KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24932 HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPPL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21376 primary cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.571745 Genetic disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835218 CRCGN017_MCF10A.TP53.M_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1076 cell projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.451233 GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Crizotinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166693 Parkinson's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.259 GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.349145 tetroquinone-3338 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lung TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.330827 fulvestrant-1205 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-Q2AH-0126-SM-48U2B GTEx Tissue Sample Gene Expression Profiles 1.0 1.22053 OC-10-FB51_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.02974 spermatozoon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.535438 GTEX-U3ZN-0326-SM-3DB86 GTEx Tissue Sample Gene Expression Profiles 1.0 0.934348 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93215 NFATC1 ENCODE Transcription Factor Targets 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null leflunomide-2539 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Trichostatin A_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00943641 ATG4B Pathway Commons Protein-Protein Interactions 1.0 null Sleep disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.82 Craniofacial Abnormalities CTD Gene-Disease Associations 1.0 1.02634 renal corticomedullary cysts HPO Gene-Disease Associations 1.0 null Peripheral nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.306 NCI-H2803 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.31554 SW1271_LUNG CCLE Cell Line Proteomics 1.0 5.16405 adrenal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.095085 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-1826-SM-2YUNP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02108 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K68916730 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29201 SK-UT-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.80783 YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACTA2 Pathway Commons Protein-Protein Interactions 1.0 null EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null MCRIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67676 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08548 TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2906 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDK12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20957 sparteine-2790 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null USF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dihydrostreptomycin-2074 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_CYC116_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176715 BRD-K53662389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15336 BRD-K56065989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33336 BRD-K82362034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09171 K562_Ki16425_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178662 GSE226316_11_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CW2 CCLE Cell Line Gene Expression Profiles 1.0 1.69451 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KRT75 Pathway Commons Protein-Protein Interactions 1.0 null Polycystic liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.074 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.5906 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16542 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cyclobenzaprine-4252 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ACADM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36106 SOX2-22085726-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.955881 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DSG1 Pathway Commons Protein-Protein Interactions 1.0 null Cerebral peduncle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.356 abnormality of the renal tubule HPO Gene-Disease Associations 1.0 null HSPA5 Pathway Commons Protein-Protein Interactions 1.0 null nalidixic acid-7367 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-R55E-0006-SM-2TC5G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925025 REV3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27738 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K60701773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94893 hsa-miR-32 TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 TUBB4B Pathway Commons Protein-Protein Interactions 1.0 null Myelencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.151 2-PMPA DeepCoverMOA Drug Mechanisms of Action 1.0 0.31 BRD-K64730761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77611 GNA11 Pathway Commons Protein-Protein Interactions 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NFKB1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QDVJ-0626-SM-48U1T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.919991 type 2 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.800979 NE-94-VE83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209298 GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-V1D1-2026-SM-3GAF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29794 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 2.29539 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.949125 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.18724 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM5A ENCODE Transcription Factor Targets 1.0 null GTEX-SE5C-0626-SM-2XCDV GTEx Tissue Sample Gene Expression Profiles 1.0 1.04487 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.896398 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08353 chronic pancreatitis HPO Gene-Disease Associations 1.0 null FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3940-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE82110,GSE82299_1_v_0_acriflavine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.25582 bone marrow HPA Tissue Protein Expression Profiles -1.0 -1.52503 NKX2-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.8199 A549_WHI-P154_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015532 BRD-K94629607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02593 PCMT1 Pathway Commons Protein-Protein Interactions 1.0 null PMC7339546-12915_2020_793_MOESM2_ESM.xlsx-Table_S12-Table_S12_common_twin_genes_in_one_HMR_core_region_between_cattle_and_human_NR4A1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K46737746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03753 CAD Pathway Commons Protein-Protein Interactions 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lidocaine (hydrochloride)_HEC-1-A Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.00917239 hsa-miR-181b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 TUFM Pathway Commons Protein-Protein Interactions 1.0 null organelle LOCATE Curated Protein Localization Annotations 1.0 null Encephalopathy due to defective mitochondrial and peroxisomal fission 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.0 BRD-K97638135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07415 GSE138672_0_v_1_rabgef1_mouse RummaGEO Gene Perturbation Signatures 1.0 null transition metal ion binding GO Molecular Function Annotations 2015 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null DPM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12289 KDM5A ChEA Transcription Factor Targets 1.0 null PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF Rummagene Transcription Factor Associations 2026 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5L4-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_GSK1070916_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014339 trastuzumab_homo sapiens_gpl6947_gse31432 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13988 GSE223893_1_v_9_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null Organic acidemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.108 HSPA4L Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPA3 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-298 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 TRA2A Pathway Commons Protein-Protein Interactions 1.0 null HSPA6 Pathway Commons Protein-Protein Interactions 1.0 null AC-55-XA97_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.860888 GSE192689_0_v_1_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Lung Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.832363 GTEX-V955-0426-SM-3GAEL GTEx Tissue Sample Gene Expression Profiles 1.0 0.956739 CAY-10397-7071 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7150-01A-21R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XLM4-0011-R9A-SM-4AT45 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903016 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10023 bezafibrate-1275 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K41310621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27709 ADCY8 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K33956641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16135 A549_Meprednisone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142342 PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF Rummagene Transcription Factor Associations 2026 1.0 null BRD-K61795707 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0655 Perturb_17648_KO_CEP83_SRP379856 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.88888 MYC ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7854-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZC3H11A ENCODE Transcription Factor Targets 1.0 null OB-06-WW76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.497467 Aorta thoracica smooth muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.517 BRD-K42769174 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25052 2793_EXOSC6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.553442 GSE118816_2_v_3_myo1c_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE229914_1_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06596 ZNF384 ENCODE Transcription Factor Targets 1.0 null GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29344 Memory Disorders CTD Gene-Disease Associations 1.0 1.41368 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5463-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K23868551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1062 demecarium bromide-6269 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-302b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GFAP Pathway Commons Protein-Protein Interactions 1.0 null 496100496_FWM_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.1228 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K29260599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47643 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null tacrolimus-169 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AMO1 CCLE Cell Line Gene Expression Profiles 1.0 1.38451 BRD-K98432726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32301 transient Purkinje cell clusters Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1913 LGALS3BP Pathway Commons Protein-Protein Interactions 1.0 null caudal prosubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09718 procaine-6329 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A43575461 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1877 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amitriptyline-6353 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CFTR Pathway Commons Protein-Protein Interactions 1.0 null BRD-K57782577 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61767 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZE-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ethotoin-4545 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14946 GSE120248,GSE120252_1_v_0_macf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R53T-0926-SM-3GADH GTEx Tissue Sample Gene Expression Profiles 1.0 1.28629 TAF15 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K49584388 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47001 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22051 BRD-K12984952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10491 GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944568 BRD-K22800340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46615 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-CA-04-2009(H1N1)_36Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.44964 HNF4A-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null RERF-LC-KJ COSMIC Cell Line Gene Mutation Profiles 1.0 null glucose metabolism disease GWASdb SNP-Disease Associations 1.0 0.297546 ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07091 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null canadine-4020 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SHSY5Y CCLE Cell Line Gene CNV Profiles -1.0 -2.1659 BOLA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43112 CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K84334677 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14365 CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K47092271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04721 nordihydroguaiaretic acid-1164 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CP in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65061 TEAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6513 CRCGN012_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.45951 PMC9314667-Table_1.xlsx-Regulons-XBP1_XBP1 Rummagene Transcription Factor Associations 2026 1.0 null IZ in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.916853 POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Baricitinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0138373 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_8_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null tiaprofenic acid-4091 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LCLC-103H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.77872 HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.870154 RARB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8386 HT144SKINFV1 DepMap CRISPR Gene Dependency 1.0 2.11637 GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05831 bretylium tosilate-6674 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K19492738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71943 BRD-K81954791 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06433 BRD-K79148949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05006 Perturb_14833_KD_Scr_SRP017110 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40519 metal ion binding GO Molecular Function Annotations 2015 1.0 null ion binding GO Molecular Function Annotations 2015 1.0 null Alzheimer disease specific cell type TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.55 PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null K562_Sodium Phenylbutyrate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0209534 KRT76 Pathway Commons Protein-Protein Interactions 1.0 null Outer dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.903 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Neutropenia CTD Gene-Disease Associations 1.0 1.03308 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K30220159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77821 GTEX-Q734-0526-SM-2I3EH GTEx Tissue Sample Gene Expression Profiles 1.0 1.28336 H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24518 H2BK12ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Epithalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.488 ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26766 MAP1LC3B Pathway Commons Protein-Protein Interactions 1.0 null piroxicam-7445 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A549_PFI-1_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0184733 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null phenazone-4251 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49475 PFN1 Pathway Commons Protein-Protein Interactions 1.0 null 9689_UVRAG_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.585552 HDAC2 ENCODE Transcription Factor Targets 1.0 null A549_Cimetidine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187906 USF1_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.9885 SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Thylakoid membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.89 A549_ENMD-2076 L-Tartaric acid_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0264616 A549_Veliparib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153944 rolitetracycline-3369 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCIH1573_LUNG CCLE Cell Line Proteomics 1.0 2.16993 BRD-K24076516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06406 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3835 equilin-3377 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Edema CTD Gene-Disease Associations 1.0 1.29533 endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044874 HNRNPH1 Pathway Commons Protein-Protein Interactions 1.0 null TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.895315 XRCC6 Pathway Commons Protein-Protein Interactions 1.0 null parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.81004 PKM Pathway Commons Protein-Protein Interactions 1.0 null GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03396 Fundus dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 STAT3 ENCODE Transcription Factor Targets 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEx Brain 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 12.0449 Melancholic depression DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.512 UBR5 Pathway Commons Protein-Protein Interactions 1.0 null K562_AT9283_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161004 Inner mitochondrial membrane protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.747 SERBP1 Pathway Commons Protein-Protein Interactions 1.0 null REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null glomerular filtration GO Biological Process Annotations 2015 1.0 null A7r5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.658 EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.70908 TIM22 mitochondrial import inner membrane insertion complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.683 NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.51749 Axoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.199 dizocilpine-1386 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of body weight GWASdb SNP-Phenotype Associations 1.0 0.342344 GSE242199_2_v_5_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null Intraciliary transport particle A COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.726 A549_WP1066_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0189143 BRD-K04238122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11179 GSE192513,GSE192515_2_v_0_atg16l1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PEO4 DepMap CRISPR Gene Dependency 1.0 2.7672 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null glucose GAD Gene-Disease Associations 1.0 null NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PPARGC1A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sec61 translocon complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.665 PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-Genes_with_ATF3_combined_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Toxic encephalopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 renal filtration GO Biological Process Annotations 2025 1.0 null trifluoperazine-1224 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null JAK2_mutant_40_GSE11003 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.85792 OVISE Achilles Cell Line Gene Essentiality Profiles -1.0 -1.70312 2791_EXOSC4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.630889 OVKATE CCLE Cell Line Gene CNV Profiles -1.0 -1.5277 proton-transporting ATP synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.019 small intestine HPA Tissue Protein Expression Profiles 1.0 0.703068 Methotrexate_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0191267 GTEX-VUSG-2826-SM-4KKZM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.940173 hsa-miR-3120-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30359 hexamethonium bromide-4965 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HOXC9 ChEA Transcription Factor Targets 1.0 null BRD-K83307202 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00066 BRD-K48676303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00656 Perturb_13502_KD_WDR5_SRP321449 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.35606 A4FUK CCLE Cell Line Gene Expression Profiles 1.0 1.72641 K562_Cyclocytidine HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0202812 QTRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15584 H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K00542622 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29267 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Cimetidine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159025 CRCGN015_MCF10A.TP53.M_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01095 HCC202 CCLE Cell Line Gene CNV Profiles 1.0 2.2904 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K82224868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88803 Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.82 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SARS-CoV_84Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.99355 LCLC103H CCLE Cell Line Gene Expression Profiles -1.0 -1.62851 GTEx Uterus 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 5.21916 SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30101 adrenal gland HPA Tissue Protein Expression Profiles 1.0 0.703068 tiabendazole-2479 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.26514 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4724-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Small intestine mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.577 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Glesatinib(MGCD265)_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177506 PAM complex, Tim23 associated import motor COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.926 GSE139239_1_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.948485 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26735 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5188 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75492 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.313 GSE158632_2_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null 23132-87 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN Rummagene Transcription Factor Associations 2026 1.0 null BRD-K45222498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01945 BJAB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38176 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.565 KCTD21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36423 kawain-2299 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K71537757 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56576 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SIN3B ChEA Transcription Factor Targets 1.0 null CCBL2 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-545 TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null aorta smooth muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.668843 hsa-miR-548i TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 GSE226249_0_v_6_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null CREB1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null carcinine-3242 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CL-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WL46-0526-SM-3LK7W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888067 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.93036 tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.167557 PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null TE9 DepMap CRISPR Gene Dependency 1.0 2.68598 A549_Roscovitine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0131183 Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29563 Optic atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.018 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A60487173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52209 MCF7 CCLE Cell Line Gene CNV Profiles -1.0 -1.78966 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KRT2 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4766-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CL11 CCLE Cell Line Gene CNV Profiles -1.0 -1.58247 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-302e TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.999822 Autosomal recessive disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 Mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 temporal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.849646 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30736 GTEX-T6MO-0126-SM-4DM6X GTEx Tissue Sample Gene Expression Profiles 1.0 1.10533 GSE245270_2_v_0_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null proguanil-5506 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.926148 globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.42818 hsa-miR-548ak TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 4,5-dianilinophthalimide-624 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null genetic disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null TRIM14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18466 COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16132 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.97718 hippocampus (hippocampal formation)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29262 GTEX-SJXC-0008-SM-4DM7G GTEx Tissue Sample Gene Expression Profiles 1.0 0.901452 BRD-K31441930 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.01008 AIFM1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57685 ALDH1B1 Pathway Commons Protein-Protein Interactions 1.0 null Pars intermedia TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.566 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.827506 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE158834_10_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Macronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.678 BRD-K93945680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0223 extracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cogan syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.326 Senior-Loken syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.864 GTEX-T2IS-3026-SM-32QPM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945556 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARID3A JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K22778609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24169 PD-70-VS77_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.339201 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4Z8-0126-SM-4GICC GTEx Tissue Sample Gene Expression Profiles 1.0 1.10884 GSE147876,GSE147877_4_v_8_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06289 GSE244518,GSE244520_1_v_0_dnmt3b_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.9187 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K20110031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41548 abnormality of the urinary system HPO Gene-Disease Associations 1.0 null primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08366 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Neoplasms CTD Gene-Disease Associations 1.0 1.33761 BRD-K47326075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68707 Leptomeninx TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.814 TP53INP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08965 nordihydroguaiaretic acid-2683 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null diclofenamide-3366 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-153 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 DMWD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01874 BRD-K35413741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11422 Lymphocytic leukemia cell line TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 K562_Ki16425_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180801 BRD-K79568363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95188 BRD-A64774838 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82705 496100622_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01096 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.13649 SEC61A1 Pathway Commons Protein-Protein Interactions 1.0 null ANAPC10 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE190235_1_v_2_foxo3_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC8566473-41467_2021_26653_MOESM3_ESM.xlsx-SOX2_interacting_proteins-Gene_symbol_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE241036_4_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null growth abnormality GWASdb SNP-Phenotype Associations 1.0 0.272382 male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.268687 GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92805 hsa-miR-4496 TargetScan Predicted Conserved microRNA Targets 1.0 0.092495 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Colorectal Carcinoma DisGeNET Gene-Disease Associations 1.0 null BRD-K44956383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07274 QB-69-QH67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.300437 EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DAZAP1 Pathway Commons Protein-Protein Interactions 1.0 null SYNCRIP Pathway Commons Protein-Protein Interactions 1.0 null a2h TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.748 peptidase activity, acting on l-amino acid peptides GO Molecular Function Annotations 2015 1.0 null hsa-miR-634 TargetScan Predicted Conserved microRNA Targets 1.0 0.078844 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.868 Ciliopathies WikiPathways Pathways 2024 1.0 null GTEX-OXRL-1826-SM-2YUMV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892556 GSE147959,GSE147960_5_v_3_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null benzbromarone-6669 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30922 BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K09366011 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29531 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.688 LY-2584702 (tosylate salt)_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.00904715 flavoxate-7405 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ERMES complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.572 2291_DNAJC17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.6161 GSE193258,GSE193259_9_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K92981306 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33953 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60457 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WX-01A-22R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114258_3_v_2_foxk1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE213588_9_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03402 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.147 RecQ family helicase-topoisomerase III complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.557 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MN-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of pancreas physiology HPO Gene-Disease Associations 1.0 null GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.43233 MCF7_Enzastaurin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162704 SFPQ Pathway Commons Protein-Protein Interactions 1.0 null NB-24-VE53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.284898 bergapten LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2856 OACP4C COSMIC Cell Line Gene CNV Profiles 1.0 2.14116 RBM39 Pathway Commons Protein-Protein Interactions 1.0 null Subthalamic nucleus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.093 Perturb_8403_KD_Safb_SRP234723 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.08218 primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05907 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.331719 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null KPNB1 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K86039224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90205 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null estradiol-1149 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.171839 hsa-miR-372 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-5144-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1419 CCLE Cell Line Gene Expression Profiles 1.0 1.40654 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WL46-0011-R7A-SM-3LK7X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93296 HSF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51709 Urinary system disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null aminopeptidase activity GO Molecular Function Annotations 2023 1.0 null NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NPHP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.414 urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.661116 chlorambucil-4523 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OIZI-0726-SM-2XCEI GTEx Tissue Sample Gene Expression Profiles 1.0 0.926061 GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.03291 VIM Pathway Commons Protein-Protein Interactions 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.836702 GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06426 Leaf disc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.593 thioridazine-1171 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12529 GSE175787_13_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Middle temporal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.668 CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1236 TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16456 NIFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12525 pontine raphe nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.970365 CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAFF ENCODE Transcription Factor Targets 1.0 null PMC12627768-41598_2025_24410_MOESM1_ESM.pdf-6-DDIT3_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSTP1 Pathway Commons Protein-Protein Interactions 1.0 null muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073935 labetalol-6809 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Caudate nucleus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.083 lateral ventricle HPA Tissue Protein Expression Profiles -1.0 -0.968536 JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6882 Sarcoma_SARC_TCGA-DX-A6YS-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SJXC-0326-SM-2XCFI GTEx Tissue Sample Gene Expression Profiles 1.0 1.02891 BRD-K97700172 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87156 outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13925 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null carmustine-6914 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Rfx6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.588 GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 0.876512 stratum pyramidale of caudal CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2028 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9703992-peerj-10-14124-s005.xlsx-gene_sets_cub_to_canonical-TFAP2E_TFAP2E Rummagene Transcription Factor Associations 2026 1.0 null GSE169205_3_v_5_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null A549_ENMD-2076_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165932 NELFE ENCODE Transcription Factor Targets 1.0 null TSPYL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4301 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70904 toxin-antitoxin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.732 GSE169205_0_v_5_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.79059 hsa-miR-425 TargetScan Predicted Conserved microRNA Targets 1.0 0.09606 A549_WP1066_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149629 TAF1 ENCODE Transcription Factor Targets 1.0 null GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.37238 HSF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0426 HCC1428 DepMap CRISPR Gene Dependency 1.0 2.83215 BRD-K35975002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09484 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.59882 ATF3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Olfactory lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.143 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.45567 CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.6034 GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.77267 Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCNA Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Belinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00915101 BRD-K45713337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4681 antimycin A-1414 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 2.07206 GSE116810_5_v_3_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-511 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 BRD-K17708304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17217 GTEX-POMQ-1426-SM-3P61D GTEx Tissue Sample Gene Expression Profiles 1.0 0.894378 GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72351789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78248 ofloxacin-2340 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sarcoma_SARC_TCGA-PT-A8TR-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HIST1H1C Pathway Commons Protein-Protein Interactions 1.0 null RCBTB1 Pathway Commons Protein-Protein Interactions 1.0 null TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13552 SRF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mode of inheritance HPO Gene-Disease Associations 1.0 null disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null BRD-K94833531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27262 KYSE-30 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-4747-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Roxadustat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0221092 GTEX-PWOO-0326-SM-48TDB GTEx Tissue Sample Gene Expression Profiles 1.0 0.84688 GTEX-X8HC-0726-SM-46MWG GTEx Tissue Sample Gene Expression Profiles 1.0 1.13028 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26735 prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34423 496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.39271 BRD-K91818277 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40424 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -3.19943 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25289 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-548t TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15764 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Food vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.603 CRCGN014_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9453 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.367006 AD-51-FB60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.318077 Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.688 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R4-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.926536 BRD-K79355381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42587 GTEX-QEG5-0826-SM-2I5GF GTEx Tissue Sample Gene Expression Profiles 1.0 0.872817 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.925329 Polydactyly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.36 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null BRD-K13257316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07497 BRD-K46014233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80466 K562_Roscovitine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0171051 GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27134 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT549_BREAST CCLE Cell Line Proteomics 1.0 2.02035 CRCGN008_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0797 GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45035 PMC4271336-13041_2014_88_MOESM6_ESM.xlsx-Genes_in_GENE_CARD_MR_or_ID-Gene_Cards_MR_and_ID_genes_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29367 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.7364 NIHOVCAR3 DepMap CRISPR Gene Dependency 1.0 3.44282 H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Spondylometaphyseal dysplasia Megarbane-Dagher-Melike type DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.517 GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K75037209 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21524 ATP5A1 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6U2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HLE CCLE Cell Line Gene Expression Profiles -1.0 -2.27311 BRD-K72071403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12055 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMK1-0226-SM-4B65D GTEx Tissue Sample Gene Expression Profiles 1.0 1.08912 CRCGN015_HEPG2_48H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11149 GSE237053_1_v_0_comt_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OHPL-1326-SM-3MJGG GTEx Tissue Sample Gene Expression Profiles 1.0 0.962384 GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48767 SCLC21H CCLE Cell Line Gene CNV Profiles -1.0 -1.36116 BRD-K86373784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.36782 TAF7L-23326641-C3H10T1-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RAB35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19057 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lytic vacuole LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-W5X1-2326-SM-3GIL6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.887599 POLR2A_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.82963 BRD-K55220938 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02578 hsa-miR-664 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellum HPA Tissue Protein Expression Profiles -1.0 -0.812903 ILF2 Pathway Commons Protein-Protein Interactions 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-0626-SM-4AD5M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945926 striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.990825 GTEX-QDVN-0626-SM-2I3FP GTEx Tissue Sample Gene Expression Profiles 1.0 0.905006 CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80864 BRD-K69791255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14371 USF2 ENCODE Transcription Factor Targets 1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE202603_3_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures -1.0 null FLNC Pathway Commons Protein-Protein Interactions 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-5395-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K70093308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57432 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DL-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K05127596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7474 PMC10792109-NIHMS1929238-supplement-Supplemental_Table_6.xlsx-intersection_genes_up-FOXJ1_FOXJ1 Rummagene Transcription Factor Associations 2026 1.0 null K562_Zileuton_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172299 ZNF793 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69058 Retinal degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 Inner ear disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.17 K562_JNJ-26854165_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0213382 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null pentoxifylline-2127 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Plasma membrane-derived thylakoid membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.553 mecamylamine-7023 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HNRNPCL1 Pathway Commons Protein-Protein Interactions 1.0 null clindamycin-2057 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211296 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WSB1 Pathway Commons Protein-Protein Interactions 1.0 null A2780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.974338 GSE160765_2_v_1_twist1_human RummaGEO Gene Perturbation Signatures -1.0 null A549_PHA-680632_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.011257 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.995182 SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSPB1 Pathway Commons Protein-Protein Interactions 1.0 null oxymetazoline-1431 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K41684304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08495 GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995468 Prostate adenocarcinoma_PRAD_TCGA-VP-A87D-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null short insular gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.878346 H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69702 stomach HPA Tissue Protein Expression Profiles 1.0 0.703068 BRD-A98208100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42611 F36P DepMap CRISPR Gene Dependency 1.0 4.75492 GTEX-PLZ5-0326-SM-3P614 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05298 HNRNPH3 Pathway Commons Protein-Protein Interactions 1.0 null EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CZIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72363 CRCGN015_MCF10A.WT.HP_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.16245 H2AFZ ENCODE Transcription Factor Targets 1.0 null BRD-K67626097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35852 Lymphoblastoid cell line TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 Intraciliary transport particle B COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.774 PSMD12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10477 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YQ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HUP-T4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.921507 MXI1 ENCODE Transcription Factor Targets 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null prochlorperazine-5212 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSP90AB2P Pathway Commons Protein-Protein Interactions 1.0 null BRD-K99982687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20254 duodenum_4c HPA Tissue Sample Gene Expression Profiles -1.0 -1.22002 GSE158834_12_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02985 PDIA6 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05356 GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 1.42781 9+0 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.74 Brain Lower Grade Glioma_LGG_TCGA-FG-7637-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125014_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC9068765-41467_2022_29960_MOESM14_ESM.xlsx-TP53-Unnamed_2_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.86157 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4775-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW837 CCLE Cell Line Gene CNV Profiles -1.0 -1.44875 proteolysis GO Biological Process Annotations 2023 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null GTEX-U8XE-1226-SM-4E3HN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916987 multidrug-resistant tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.291 posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.863347 PKIG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23776 monogenic disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GTEX-PVOW-0626-SM-2XCF6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22506 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.05588 Respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the pancreas HPO Gene-Disease Associations 1.0 null BRD-K08607520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46742 ZNF384_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-2126-SM-3GILK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.936558 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 MYC-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_RXRB-gene_RXRB Rummagene Transcription Factor Associations 2026 1.0 null BRD-K00676343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29874 aorta TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.182499 GTEX-P44H-0226-SM-2XCEU GTEx Tissue Sample Gene Expression Profiles 1.0 1.01606 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE10 CCLE Cell Line Gene CNV Profiles 1.0 1.99739 BRD-K05251963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06066 smallintestine_4b HPA Tissue Sample Gene Expression Profiles -1.0 -1.17281 MOLT-4 cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSPD1 Pathway Commons Protein-Protein Interactions 1.0 null GSE163240_3_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.990796 GTEX-R53T-0526-SM-3GADL GTEx Tissue Sample Gene Expression Profiles 1.0 1.15115 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-150 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 TRIM28 Pathway Commons Protein-Protein Interactions 1.0 null nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051505 C5orf24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06127 anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.890391 USF1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSF1-23293686-STHDH-STRIATAL-MOUSE ChEA Transcription Factor Targets 2022 1.0 null FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null metamizole sodium-4310 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90954 estrone-4993 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mifepristone_homo sapiens_gpl6947_gse39654 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cerebellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.078423 Nephronophthisis-like nephropathy 1 ClinVar Gene-Phenotype Associations 1.0 null TAF7_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.529222 Kinetic Tremor DisGeNET Gene-Phenotype Associations 1.0 null TRIM16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33473 dexamethasone-123 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.52002 BRD-K42400613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41643 fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-QEG4-0426-SM-33HC3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.863529 BRD-K61660466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62287 Pineal gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.488 UACC893 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.646104 JHH2 CCLE Cell Line Gene CNV Profiles 1.0 1.87686 LIN7C Pathway Commons Protein-Protein Interactions 1.0 null U-373MG cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.625 icSARS CoV_54Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.82663 WB-82-EL69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.336068 theophylline-4812 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_WI38_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.76597 Ciliary membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.888 C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.66676 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19587 GTEX-U8XE-0008-SM-4E3K4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06246 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SL-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null icSARA deltaORF6_24Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.28591 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37206 Nephronophthisis DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 4.0 ramipril-6792 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HNRNPR Pathway Commons Protein-Protein Interactions 1.0 null A549_MC1568_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0268222 CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Endocrine pancreas TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.175 SNRPB Pathway Commons Protein-Protein Interactions 1.0 null SNU475 CCLE Cell Line Gene Expression Profiles -1.0 -1.77357 PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61883 CLCA1 Pathway Commons Protein-Protein Interactions 1.0 null HNRNPU Pathway Commons Protein-Protein Interactions 1.0 null butyl hydroxybenzoate-4647 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nicergoline-6251 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08679933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15196 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Iniparib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0174276 orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.847513 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.870987 hydroflumethiazide-7019 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN013_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.70458 troglitazone-1070 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Midgut epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.791 PDHB Pathway Commons Protein-Protein Interactions 1.0 null Cingulate cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.272 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2BK120ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_S3I-201_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178717 GSE180525,GSE180528_1_v_0_tbx3_human RummaGEO Gene Perturbation Signatures 1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.28282 GB-73-QS80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.297577 DD-74-PJ26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.85587 CRCGN013_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91419 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.288 KLF4 ChEA Transcription Factor Targets 1.0 null MYCN ChEA Transcription Factor Targets 1.0 null GTEX-QEL4-0726-SM-3GIJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21209 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hsa-miR-4310 TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 Tubular Atrophy DisGeNET Gene-Phenotype Associations 1.0 null PRECLH CCLE Cell Line Gene Expression Profiles -1.0 -1.59739 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V955-0126-SM-4JBH5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31255 ZR75_1 BioGPS Cell Line Gene Expression Profiles 1.0 2.41625 GTF2F1 ENCODE Transcription Factor Targets 1.0 null COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.71159 CRCGN016_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20297 BRD-K96627018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33864 IRF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K77663497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15761 Bone development disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.112 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELAVL1 Pathway Commons Protein-Protein Interactions 1.0 null PMC12697907-ADVS-12-e07451.nxml-Table_2-Gene_cancer_MR_information_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.99815 ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPP2R1A Pathway Commons Protein-Protein Interactions 1.0 null CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.7097 GSE180185_4_v_1_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-520f TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 MESSA CCLE Cell Line Gene Expression Profiles 1.0 1.56145 GSE110708_2_v_3_adar_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4780 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 phenformin-4283 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14355 SARS-CoV_60Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.66391 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE226249_5_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null pargyline-1418 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00233 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SG-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K87879912 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84825 GSE191015_1_v_3_gsdmb_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25677 arachnoid cyst HPO Gene-Disease Associations 1.0 null FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.08981 vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.089058 testis_7b HPA Tissue Sample Gene Expression Profiles 1.0 1.39529 colecalciferol-6656 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EA-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRRM2 Pathway Commons Protein-Protein Interactions 1.0 null exopeptidase activity GO Molecular Function Annotations 2023 1.0 null GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0694 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.465723 KRT71 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-559 TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 TEAD4 ENCODE Transcription Factor Targets 1.0 null GTEx Brain 20-29 vs 40-49 GTEx Tissue-Specific Aging Signatures 1.0 9.13938 AA-70-VU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296148 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.882787 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.83532 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null kidney disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null alsterpaullone-7078 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-62-MNT_MNT Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WYJK-0005-SM-3NMA1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17642 ribostamycin-3444 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BCLAF1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV_72Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.36177 BRD-K17718789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50666 SRSF1 Pathway Commons Protein-Protein Interactions 1.0 null GSE213588_10_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.276443 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03243 SLR24 CCLE Cell Line Gene Expression Profiles -1.0 -1.54685 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0426-SM-3NB2E GTEx Tissue Sample Gene Expression Profiles 1.0 0.829467 CUL3 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN014_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.83411 lung_4d HPA Tissue Sample Gene Expression Profiles -1.0 -1.65032 GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 1.66505 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.2257 internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06371 TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05666 KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.93172 Acute Myeloid Leukemia_LAML_TCGA-AB-2913-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null canrenoic acid-7135 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null posterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.97039 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2333 BRD-A55411938 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26009 flutamide-4361 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Targets 2022 1.0 null medial orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.975339 GSE119978,GSE180930_2_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Congenital Cystic Kidney Disease DisGeNET Gene-Disease Associations 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Roscovitine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141537 GTEX-OHPN-0011-R1A-SM-2I5GB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00134 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chromosomal duplication syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.374 CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.5804 LY-294002-4440 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Huntington's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.062 Refractive error GWAS Catalog SNP-Phenotype Associations 2025 1.0 2.6699 HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.1486 abnormal glucose homeostasis GWASdb SNP-Phenotype Associations 1.0 0.304227 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZT-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33825 HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.45643 PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null lynestrenol-2037 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_HEPG2_48H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.48265 hsa-miR-302a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE199660_1_v_3_secretin_mouse RummaGEO Drug Perturbation Signatures 1.0 null DF-95-CY55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.298201 USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01915 ZNF143 ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2868-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59875 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZN-0826-SM-4DXSZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.12862 chromaffin cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.434906 JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SYNGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05415 piperine-3263 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2109 cd8 cells HPM Cell Type and Tissue Protein Expression Profiles 1.0 1.06269 GTEX-OIZH-0326-SM-2HMKC GTEx Tissue Sample Gene Expression Profiles 1.0 1.03964 GSE147876,GSE147877_4_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RTLS-2426-SM-46MUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.15524 GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.63056 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null etifenin-3998 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.78843 GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 2.55732 CREB1 ChEA Transcription Factor Targets 1.0 null BRD-K43203897 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.12492 GTEX-QLQ7-1626-SM-2S1R8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04723 GSE81193_3_v_4_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null KRT5 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormality of nervous system morphology HPO Gene-Disease Associations 1.0 null H3K79me2_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal renal morphology HPO Gene-Disease Associations 1.0 null GSE142232,GSE142234_0_v_2_gcgr_mouse RummaGEO Gene Perturbation Signatures 1.0 null HLF CCLE Cell Line Gene Expression Profiles -1.0 -1.85099 H4K8ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K63665694 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50851 mr89 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.942 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K54285478 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20857 ZNF316 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88304 SLC16A1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null mitochondrial GeneRIF Biological Term Annotations 1.0 null GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 1.00642 GSE166920_6_v_1_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SK-MEL-2 COSMIC Cell Line Gene CNV Profiles 1.0 2.14116 GSTA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08791 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_10_v_6_palm_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN011_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.3435 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.076022 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A85H-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSP90AB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11243 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AE-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE123105,GSE124556_0_v_2_pcf11_human RummaGEO Gene Perturbation Signatures 1.0 null SNRPD3 Pathway Commons Protein-Protein Interactions 1.0 null Nephronophthisis 7 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.336 VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Cytosolic proteasome complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.19119 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K36320220 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14153 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.934891 C6orf48 Pathway Commons Protein-Protein Interactions 1.0 null 647-V Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.53057 RPMI8226 DepMap CRISPR Gene Dependency 1.0 3.34357 flufenamic acid-5478 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PLRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0682 aztreonam-2118 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AU-01A-32R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBMX Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Maraviroc_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0238003 H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LCLC103H CCLE Cell Line Gene CNV Profiles -1.0 -2.73358 abnormal auditory brainstem response IMPC Knockout Mouse Phenotypes 1.0 null Ciliary transition zone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.935 BRD-K60781525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23295 BRD-K55018894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51157 PMC10274973-media-3.xlsx-ST18-Unnamed_9_ST18 Rummagene Transcription Factor Associations 2026 1.0 null Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2655 SRF_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PA-TU-8902 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.70118 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9170756-mmc6.xlsx-P6-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN Rummagene Transcription Factor Associations 2026 1.0 null SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63299 RWDD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11247 SNU349 CCLE Cell Line Gene Expression Profiles -1.0 -1.6384 GSE213588_8_v_1_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H2135 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.96934 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2157 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.35455 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACTBL2 Pathway Commons Protein-Protein Interactions 1.0 null av3 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.085 DYNC1LI1 Pathway Commons Protein-Protein Interactions 1.0 null JUN_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EOGT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01401 SNU1077 DepMap CRISPR Gene Dependency 1.0 2.09897 BRD-K38713368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01758 abnormality of the endocrine system GWASdb SNP-Phenotype Associations 1.0 0.139004 Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TB-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JEKO1 CCLE Cell Line Gene CNV Profiles 1.0 1.36774 GTEx Colon 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 5.64289 epididymis HPA Tissue Protein Expression Profiles 1.0 0.703068 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF7 ENCODE Transcription Factor Targets 1.0 null ZNF384_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.17671 BRD-A16313205 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78664 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21591 mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29584 SNU668 DepMap CRISPR Gene Dependency 1.0 2.34874 SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Floral primordium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.909 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.40802 GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.9221 BRD-K87158974 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22051 BRD-K34929471 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69769 Embryonic brain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.195 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAPNS1 Pathway Commons Protein-Protein Interactions 1.0 null REST_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158632_3_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5451-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Orofaciodigital syndrome III DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.532 BRD-K84073439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80409 CUX1 ENCODE Transcription Factor Targets 1.0 null BRD-K04875192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18343 H3K79me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30214140 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12198 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null GSE221327_5_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null chlorpromazine-1822 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KW-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MELHO CCLE Cell Line Gene CNV Profiles 1.0 2.19865 DYNC1H1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K26402831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62542 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null amitriptyline-167 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ATPase dependent transmembrane transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.096 KYSE70 DepMap CRISPR Gene Dependency 1.0 2.63461 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5096 carbamazepine-1847 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0042 ZHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30723 HCC1395 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.04106 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE226249_2_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K89863047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50452 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.215314 GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.60289 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null OCUM1_STOMACH CCLE Cell Line Proteomics 1.0 2.38484 wortmannin-506 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42087 KB-72-ID36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.363089 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.079064 HSPH1 Pathway Commons Protein-Protein Interactions 1.0 null hindbrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068749 SARS-CoV_96Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.07058 Intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.322 NCIH2122 Achilles Cell Line Gene Essentiality Profiles 1.0 1.3383 GTEX-Q734-0626-SM-2I3EF GTEx Tissue Sample Gene Expression Profiles 1.0 0.886737 BRD-K26704304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06562 GSE158834_10_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K69347147 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38374 A549_PCI-34051_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0125753 A549_MC1568_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172058 E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null methylbenzethonium chloride-3768 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K63579322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9614 MCF7_CEP-33779_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158006 MEIS1 ChEA Transcription Factor Targets 1.0 null GTEX-XV7Q-1426-SM-4BRWA GTEx Tissue Sample Gene Expression Profiles 1.0 0.897475 Levobupivacaine (hydrochloride)_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0244548 POU6F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92889 PRKCI Pathway Commons Protein-Protein Interactions 1.0 null BRD-K25176380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76335 FU97 DepMap CRISPR Gene Dependency 1.0 7.227 BRD-K43982279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72562 LN319 Achilles Cell Line Gene Essentiality Profiles 1.0 1.80313 BRD-K21819164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99745 Kidney Chromophobe_KICH_TCGA-KN-8435-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chlorzoxazone-7456 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null K562_Motesanib Diphosphate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0193254 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K86109840 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53303 depudecin-874 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886644 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NFK9-0726-SM-2HMJW GTEx Tissue Sample Gene Expression Profiles 1.0 0.954919 nephronophthisis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.54672 HUNS1 DepMap CRISPR Gene Dependency 1.0 2.05244 GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63481 RPL23A Pathway Commons Protein-Protein Interactions 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23965 MKN7 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.12912 Acute Myeloid Leukemia_LAML_TCGA-AB-2949-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null azacyclonol-6298 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K02024244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64902 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-92b TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 hsa-miR-525-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.3307 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null BRD-K42367391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61309 A549_Tazemetostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0207133 GNL3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2959 Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IQSEC1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.0228 ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16153 BRD-K64299311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15596 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052158 amygdaloid complex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06368 GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24193 GSE135514_2_v_7_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906139 GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 2.29584 BRD-K96713984 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30153 CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08549 BRD-K94790210 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08514 BRD-K39858575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73532 BRD-K24453679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61768 BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3712 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K97368902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35802 BRD-K86677819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36639 Blood cancer cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.49 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0291 PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Busulfan_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173922 GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19468 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null RELA JASPAR Predicted Transcription Factor Targets 1.0 null HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03645 GTEX-XV7Q-1526-SM-4BRWB GTEx Tissue Sample Gene Expression Profiles 1.0 0.925915 PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-genename_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K22380421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65087 LOXIMVI_SKIN CCLE Cell Line Proteomics 1.0 3.06175 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.160203 Fetal_Intestine_Small Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.3909 abnormality of the middle ear HPO Gene-Disease Associations 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.19271 NCIH1869 CCLE Cell Line Gene CNV Profiles 1.0 1.52855 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K82460510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10306 5279552-843 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gastroesophageal cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 tiratricol-1412 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1 Rummagene Transcription Factor Associations 2026 1.0 null KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.836873 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.65018 PMC3371315-NIHMS350140-supplement-11.xls-MCF7-T47D-SK-453_Up_SK-453_xls-Supplementary_Table_4_ER-negative_FOXA1_signature_Genes_increased_only_in_MB-453_and_SKBR3_cells_with_knockdown_of_FOXA1_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null roxithromycin-4778 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null difenidol-2374 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MCF7_Motesanib Diphosphate_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142034 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE200687,GSE200688_1_v_0_sox15_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE88819_3_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Oligohydramnios DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 retrorsine-4946 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K53547009 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40569 ATP2A2 Pathway Commons Protein-Protein Interactions 1.0 null GSE250089_0_v_3_epcam_human RummaGEO Gene Perturbation Signatures 1.0 null PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null Renal medulla cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.525 BHLHE40_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Abexinostat_10nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0113339 JHOM2B CCLE Cell Line Gene Expression Profiles -1.0 -1.50605 GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.24716 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08652 GTEX-U412-2026-SM-4DXSI GTEx Tissue Sample Gene Expression Profiles 1.0 0.96089 K562_A-366_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161442 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.877637 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I6-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TTN Pathway Commons Protein-Protein Interactions 1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.63066 kidney HPA Tissue Gene Expression Profiles 1.0 1.26819 hsa-miR-4439 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 BRD-K85580909 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5164 manganese ion binding GO Molecular Function Annotations 2025 1.0 null BRD-K63008302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1848 Tubulointerstitium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.243 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitochondrial crista junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.9 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.841151 H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Arachnoid mater TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.883 testis_7d HPA Tissue Sample Gene Expression Profiles 1.0 2.08835 GTEX-UJMC-1926-SM-3GADS GTEx Tissue Sample Gene Expression Profiles 1.0 0.855016 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Familial juvenile hyperuricemic nephropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.529 ATP-binding cassette (ABC) transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.196 PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38 Rummagene Transcription Factor Associations 2026 1.0 null GSE115364_0_v_1_idh3a_human RummaGEO Gene Perturbation Signatures -1.0 null MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Prednisone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175422 duodenum HPA Tissue Protein Expression Profiles 1.0 0.703068 H3K9me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null sulfathiazole-4769 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K80950551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80085 K562_PCI-34051_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163362 PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q2AG-0826-SM-2HMKF GTEx Tissue Sample Gene Expression Profiles 1.0 1.17745 BRD-K74896637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67893 EP300_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UA-39-TN76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.482564 ZNF460 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 112.272 GTEX-R55G-0126-SM-48FDS GTEx Tissue Sample Gene Expression Profiles 1.0 1.0553 GTEX-WHSE-0011-R7A-SM-3P5YZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.993125 extracellular vesicular exosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06665 Sperm individualization complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.593 H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Intention Tremor DisGeNET Gene-Phenotype Associations 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRDX1 Pathway Commons Protein-Protein Interactions 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nucleus lentiformis TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.021 pempidine-4307 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.021 GSE169152_3_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null ketorolac-3110 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MCF7_Fluorouracil_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0118884 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null hsa-miR-548ab TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 Intraciliary transport particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.854 T-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.369 H3K9ac_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K34228325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61503 hsa-miR-363 TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.57999 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.060356 hsa-miR-4704-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.454769 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3313-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null etofenamate-3989 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GMPS Pathway Commons Protein-Protein Interactions 1.0 null MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -2.42341 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Major depressive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.512 anchored component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.21531 sulfacetamide-1695 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null decitabine-920 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null anteromedial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.914318 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJWN-0126-SM-3GIK7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.844982 DJ-1_KD_GDS3750_373_human_SH-SY5Y GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BB-20-UU03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.501246 PMC6379092-elife-39598-supp2.xlsx-KLF2_target_genes-OTHER_KLF2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lansoprazole-7306 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-2426-SM-4AT55 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02273 biological_process GO Biological Process Annotations 2015 1.0 null GTEX-OHPK-2426-SM-3MJGH GTEx Tissue Sample Gene Expression Profiles 1.0 0.865618 CRCGN014_HEPG2_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.71434 GSE191015_0_v_2_gsdmb_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K20897375 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2811 K562_PD173074_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0198842 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 ILF3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09205 BRD-K31778735 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11252 CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Tanespimycin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.011404 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SH-SY5Y cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.331 MN-9D cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.515 BRD-K84320538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31571 KAT2A ENCODE Transcription Factor Targets 1.0 null extracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null RPS4X Pathway Commons Protein-Protein Interactions 1.0 null HSF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.9984 GSE216273,GSE216292_14_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null BC-84-BQ58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.55155 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 2.39667 A549_Roscovitine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0200932 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-46-CK08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.301983 Amyotrophic lateral sclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.005 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 organelle GO Cellular Component Annotations 2015 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.399611 10073_ZFC3H1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.604518 ZFP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22893 ventral tegmental area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.989114 VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.877454 hsa-miR-642a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NANOG ENCODE Transcription Factor Targets 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.986346 Movement disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.145 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K18ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12273355-12882_2025_4346_MOESM1_ESM.docx-0-SOX17_SOX17 Rummagene Transcription Factor Associations 2026 1.0 null A549_Resminostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.018322 GA-28-SS67_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.216086 TCF7L2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Sensorineural hearing loss DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.175 CH157MN CCLE Cell Line Gene Expression Profiles -1.0 -2.28231 TUBA1C Pathway Commons Protein-Protein Interactions 1.0 null androsterone-1296 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CDC23 Pathway Commons Protein-Protein Interactions 1.0 null GSE159446,GSE159449_1_v_0_tunicamycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259809 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DOLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31791 protein maturation GO Biological Process Annotations 2023 1.0 null TMEM160 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221327_1_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.04934 Brain Lower Grade Glioma_LGG_TCGA-DU-5870-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K17885598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.98519 CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38273665 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48911 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229309,GSE229314_4_v_1_elavl1_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-548a-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.454769 Nerve Degeneration CTD Gene-Disease Associations 1.0 1.36418 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.92952 ENO1 Pathway Commons Protein-Protein Interactions 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MELHO CCLE Cell Line Gene Expression Profiles 1.0 2.13524 Ciliary tip COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.673 vascular smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.194789 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K88274759 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11564 paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20623 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9396374-Table_4.XLSX-AR_related_genes_from_GeneCards-gene_symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null isometheptene-5502 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null B-lymphoblastoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.355 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46986 ZNF69 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62098 aceclofenac-7269 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cystic kidney DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.29571 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.874628 posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.894611 TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null GSE261563_9_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null APOA2 Pathway Commons Protein-Protein Interactions 1.0 null GSE178714_5_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Iniparib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0116676 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.772631 2932_RIPOR1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.670583 posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.900474 BRD-K74916896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27119 GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15305 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.939926 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null Histone locus body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.886 WM115_SKIN CCLE Cell Line Proteomics 1.0 2.05259 Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K13411423 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20622 neurodevelopmental abnormality HPO Gene-Disease Associations 1.0 null GSE166920_6_v_3_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null GSE114883_1_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null exopeptidase activity GO Molecular Function Annotations 2025 1.0 null Action Tremor DisGeNET Gene-Phenotype Associations 1.0 null HCC1143 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.939957 BRD-K08199068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20469 Prostate adenocarcinoma_PRAD_TCGA-HC-A48F-01A-11R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.17706 Ciliary basal body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.723 POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JURKAT BioGPS Cell Line Gene Expression Profiles 1.0 1.43209 HNRNPA0 Pathway Commons Protein-Protein Interactions 1.0 null STK3 Pathway Commons Protein-Protein Interactions 1.0 null UBXN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16808 BRD-K44052748 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19884 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN Rummagene Transcription Factor Associations 2026 1.0 null Bipolar Disorder_frontal cortex_GSE5389 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.72613 functional abnormality of the inner ear HPO Gene-Disease Associations 1.0 null CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null