association	dataset	threshold value	standardized value
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Resmetirom	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mesendoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.029
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9377
Renal epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
PMC7334247-12031_2020_1490_MOESM2_ESM.xls-THAP1_S21T_vs_wt-Gene_Symbol_THAP1	Rummagene Transcription Factor Associations 2026	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.9935
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217206
Antral mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.738
NCIH2170_LUNG	CCLE Cell Line Proteomics	1.0	9.62656
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Unnamed_1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
protein maturation	GO Biological Process Annotations 2025	1.0	null
S0-EE-WH3B_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258351
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7923
RNF125	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02115
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MED26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11291
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Xeroderma pigmentosum group D	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
GSE223008_11_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MROH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23926
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.117
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7529806-41467_2020_18638_MOESM7_ESM.xlsx-Supplementary_Data_4-Supplementary_Data_4_TG_of_EPAS1_EPAS1	Rummagene Transcription Factor Associations 2026	1.0	null
Root apex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.806
GSE163052,GSE163198_4_v_7_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.28
ARHGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19048
Terminal web	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.781
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.4192
4EGI-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
RAB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08094
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Abiraterone1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5046
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.638982
GSE149903_6_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JOSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22607
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NDUFA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39992
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232472_1_v_2_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Secondary cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.541
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8966
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GSC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5672
NRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04933
ACTR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01167
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21135
PMC12179407-MCO2-6-e70261-s004.xlsx-up_TET3-KO_PQ_vs_Cas9_PQ-Unnamed_10_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57318
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5059
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41851
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
STX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20183
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Table_S1_Lists_of_translational_targets_of_MYC_in_MYC_ON_vs_MYC_OFF_P493_cells_and_their_5_UTR_sequences_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
AE-09-SG21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25572
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5336
SOX13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8278
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GAL3ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06753
CE-18-CG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285182
RNASEH2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13556
increased circulating HDL cholesterol level	IMPC Knockout Mouse Phenotypes	1.0	null
QX 314	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
POLR3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03692
AA-46-GL76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274407
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.455374
Upper epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.802
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429858
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKIC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00638
PMC7316257-pone.0233899.s011.xlsx-AR_regulated_genes-genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233974
CD-13-QZ32_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219824
SCH 58261	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.582836
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior visceral endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.305
GSE207301,GSE207303_1_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10803041-elife-86204-supp2.xlsx-Bulk_-_Snc-KD_in_HT-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Rosette leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.948
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471639
GTEx Brain 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	7.07113
2-Cl-IB-MECA	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Sideroblastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215351,GSE215794_7_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7629
VASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16012
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CTNNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1313
protein metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EDEM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26335
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415038
PMC7825356-8844261.f3.docx-84-NFIB_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1341
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.975466
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.464628
OSGEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07692
Mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.619
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Melanocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-Each_THP1_Pulldown_Expt_Targets-Unnamed_9_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-60-LK14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207465
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_7_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8661_TAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.99213
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.43
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200688
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229222
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WDR89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61038
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239319
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
ZNF675	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40694
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.769998
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.883087
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322136
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GS-9620	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07288
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2649
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
VPS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2843
Sporulating cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.125
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
HEATR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11128
GSE159473_0_v_1_eif5a2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.566939
Primary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2049
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-13-PS05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276142
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ITPKC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23954
Nonphotosensitive trichothiodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
NCIH1573_LUNG	CCLE Cell Line Proteomics	1.0	2.48186
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9432
PMC4212256-mmc5.xlsx-FLI1_log2_results-MIR622_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
ASB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35024
KB-72-ID36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349765
TIMM23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0557
GSE137144_4_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
COLO678_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	4.17902
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Aztreonam	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
Petal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
ALX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38347
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LN229_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	4.44947
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EB-66-IH06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201757
GSE145311_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131425_2_v_0_arg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03825
SCYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19824
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.497
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542824
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214441
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.703686
Conduct disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF773	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29087
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5795
Palisade parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.99
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.446
1013_C18ORF32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.587786
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AGXT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90434
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323604
VB-89-RG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220404
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27358
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9435
TCEA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27026
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2228
TTC30B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61643
GSE242199_2_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2618
PMC7481169-277_2020_4194_MOESM7_ESM.xlsx-RUNX1_R174L-Unnamed_1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAGOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98272
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SHP77_LUNG	CCLE Cell Line Proteomics	1.0	3.59558
Cerebellum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE179002_4_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Spev	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.06
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501221
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7645
increased circulating alkaline phosphatase level	IMPC Knockout Mouse Phenotypes	1.0	null
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PARP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25657
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15795
EIF1AX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06233
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Leaf epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ro 28-1675	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
Root apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
IRF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07365
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ITPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20086
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222672
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.433344
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Smoking status (ever vs never smokers)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
GSE129370_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
URB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19505
GSE112761,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9602
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Distal-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04756
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.841806
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
yac1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.247
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226611
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0802
ANG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22694
APOBEC3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22889
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NKTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09225
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
CORL23_LUNG	CCLE Cell Line Proteomics	1.0	3.54533
UTP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22056
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2149
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.49986
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_11_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ANP32E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99423
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-GSEA_TET1-Unnamed_2_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.97989
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.536
Endopeptidase Clp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.656
MN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97218
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5172
PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
RH30_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.41476
GSE149124,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Translation release factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.117
NFKBIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03237
ATP6V1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02298
GSE151090_5_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ibutilide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362662
Te	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.554
5732_NOL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.702644
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SB 525334	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prucalopride	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.43546
increased circulating alkaline phosphatase level	MGI Mouse Phenotype Associations 2023	1.0	null
CIA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.441
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2276
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Milrinone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318407
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25621
SKF 89976A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
3776_HIST1H4A_ENST00000359907.3	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540875
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0639
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE94849_7_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169155_5_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42367
496100353_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27945
AR-C155858	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3b_DirectGene_FOXA1-Data3b_Genes_directly_regulated_by_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
CENPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30956
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548135
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF132	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0916
CORO1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23051
Hindbrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
SCAR complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.93
IQGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46925
Yae1-Lto1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	3.146
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.25
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_5_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1982
INCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68231
CTSV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2055
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27783
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
HTR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05244
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Bestatin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.59
ID4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2765
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.939
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.665
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
decreased prepulse inhibition	IMPC Knockout Mouse Phenotypes	1.0	null
SLC12A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36723
TECPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15944
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PDK1-In	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.5937
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46137
ZNF446	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40196
DA-17-XI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31972
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295605
35 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.22
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333887
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.300797
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.532
GSE165647_0_v_7_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.518838
Orteronel	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11865
RIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16733
RK-13 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
GNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20615
TAF1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42552
H-1152	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.5
abnormal lens morphology	IMPC Knockout Mouse Phenotypes	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-421_ChIP-Seq_H3K9me1_2_AR_differential_expression_upon_KDM3A_or_AR_knockdown_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZJ 43	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
6446_PLEKHJ1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533387
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.987336
496100489_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10925
MYL6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14792
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20508
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169155_6_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Leaf primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0598
9396_TTF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543956
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.587367
GSE193685_2_v_3_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAGLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16359
gene expression	GO Biological Process Annotations 2025	1.0	null
increased circulating lipase level	IMPC Knockout Mouse Phenotypes	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306872
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.559002
PMC6977700-aging-12-102667-s006..xlsx-Sheet1-The_identified_941_dysregulated_LmiRM-CTs_in_MI_using_traditional_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
HEC6_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.5633
ICAM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34891
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7732
RUBCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24437
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.08269
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.901611
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEx Brain 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	1.0	4.06469
COPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24395
Sideroblastic anemia 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346974
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.73011
GSE210505_0_v_1_sox1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_unique_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Abiraterone2	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
GSE210667_1_v_0_rfx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.724712
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2494
LAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66799
PMC4540202-cddis2014370x2.xls-Sheet1-Table_S2_MEIS2-responsive_genes_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10879698-mmc1.pdf-12-ZNF432_ZNF432	Rummagene Transcription Factor Associations 2026	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.457304
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.136
CNOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01322
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
XRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40648
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8273
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306285
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9117
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESCRT IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.613
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5235
6963_PWP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507948
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.9822
PMC6996923-elife-46981-supp4.xlsx-KO_Up_Only_Vs_OCT4-Column_ID_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PS-1145	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15979
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424282
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6729
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34785
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103124_1_v_0_bmpr1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228619_0_v_1_cdh11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152432_3_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Procambium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.12
GSE171837_0_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Dapiprazole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
RPL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02867
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CNIH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32829
GSE111035,GSE111040_8_v_13_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195663_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Metencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC2742312-1479-7364-3-3-221-S3.PDF-153-HOXA11_HOXA11	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3436_RACK1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2684
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Opioid use disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
abnormal lens morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.2
phenylalanine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.662
PLEKHH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13578
ZNF574	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31723
CE-04-PX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28526
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-GSEA_TET1-CCRF-CEM_SCR_vs_TET1_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
GOLGA6L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2563
Ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.363
HOXB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94011
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.60094
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3639_HAUS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.732191
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1536
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6731
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
m15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.755593
OTX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5701
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422761
TCFL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68842
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pitcher	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.155
Topiramate	DeepCoverMOA Drug Mechanisms of Action	1.0	0.89
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0176
GSE135030_8_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9405
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1242
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64322
NIHOVCAR3_OVARY	CCLE Cell Line Proteomics	1.0	2.72081
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
METTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11719
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Fluconazole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.1298
PMC10534007-Table_3.xlsx-S4_unique_down_MSC_B-159_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
iron-sulfur cluster transfer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.156
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1428
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.511608
METTL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18118
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352049
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469466
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2783
Rotigotine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
Tropicamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GSE157555,GSE157556_0_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100294_HIP_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18875
NUDT17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13305
22RV1_PROSTATE	CCLE Cell Line Proteomics	1.0	7.6005
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5602
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7059
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3954
ARHGEF39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19317
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557417
BBL023172	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3181
DSTYK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60679
XKR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22976
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TIMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25204
TTC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06854
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25796
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248388
7518_RPS27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.754982
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467998
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Attention deficit hyperactivity disorder (inattention symptoms)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
TADA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12049
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.37538
ME-62-IQ37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228236
Hydrogenosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.549
8738_TBL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511246
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242815
Photosensitive trichothiodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205952
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
NCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.39373
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ATP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30225
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IFI27L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15806
MAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34663
TRAPPC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43829
Cerebrooculofacioskeletal syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
MEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44343
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2309
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16001
PPIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28298
Antropyloric mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.733
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.700154
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2351
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231013
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100633_TCx_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29878
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.71451
GSE231648_4_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.28
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112761,GSE112767_2_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Photosensitive trichothiodystrophy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.783
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15602
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342624
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100526_TCx_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37235
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9019027-42003_2022_3332_MOESM3_ESM.xls-Table_S1_HUVEC_MED23-KD_DEGs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Fibrillar center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.651
GSE130401_6_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529024
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
PRPF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16613
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334667
9838_WDR73_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543437
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0415
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF766	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22048
rt1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.346
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199644_3_v_1_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_unique_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3833
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414298
GSE238116_3_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
616_ATG12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621918
GSE202310_1_v_0_ube3d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hydathode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.245
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0949
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100419_TCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41849
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.936498
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65122
cataract	IMPC Knockout Mouse Phenotypes	1.0	null
SUDS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02148
Gilles de la Tourette syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.989722
GSE145311_0_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cataract	MGI Mouse Phenotype Associations 2023	1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1019
ZNF837	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56669
Entospletinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TRMO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35373
GSE253041_1_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8509_STIP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511915
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.078
INCENP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04336
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53631
increased circulating cholesterol level	IMPC Knockout Mouse Phenotypes	1.0	null
GSE167886_2_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-260_ChIP-Seq_H3K9me1_2_AR_differential_down_regulation_upon_KDM3A_or_AR_knockdown_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6283_PHF19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.514434
ZNF775	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39599
GSE157049,GSE157051_6_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Polar tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.165
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Vegetative stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
protein maturation by [4Fe-4S] cluster transfer	GO Biological Process Annotations 2023	1.0	null
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.456
PMC10534007-Table_2.xlsx-S2_overlap_MSC_down_B_V-395_common_elements_in_VM-CUB1_MSC_down_and_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231106
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.767504
PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560621
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35991
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.6461
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.565
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
SKA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41976
ANOS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0751
PMC10534007-Table_3.xlsx-S4_unique_down_MSC_B_2-159_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PDK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22556
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4798
ZC3HAV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98708
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.459537
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
SLC25A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17477
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
10073_ZFC3H1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.60744
Tic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
SURF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34321
Telmisartan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
GSE157049,GSE157051_6_v_4_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112860_5_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394448
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.176
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1265
GSE111035,GSE111040_3_v_13_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Momelotinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.2
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3-isopropylmalate dehydratase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.295
Superoxide dismutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.516
YIPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17653
NCIH1792_LUNG	CCLE Cell Line Proteomics	1.0	3.54533
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.708376
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
GINS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51998
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CEP131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24867
Diethylstilbestrol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.02863
NFRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13583
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3257
GSE160246_0_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-7954	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
CYB5RL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45919
ATF7IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4283
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
ri1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.658
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Friedreich ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
GSE221004_3_v_0_prdm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
Leaf tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199541_2_v_4_mbd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588607
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1736
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6153
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.156
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0273
PRRC2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12234
ZFYVE26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08249
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHEMBL569227	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
TE10_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.35959
KRT18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22966
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	55.8882
NEUROD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4669
PJ34	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152432_9_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.592026
S0-EE-Y79N_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264857
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.102
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Root cap	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cytosolic ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.356
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3706
FCGRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1845
PMC12152148-41420_2025_2541_MOESM3_ESM.xlsx-AR-IP-DHT_peak-gene-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2778
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.744893
Microsporidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.563
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NADSYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70836
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JB-89-SI60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255833
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.988952
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9315
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8105
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224319
ZNF710	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75075
TOMM40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0176
GSE218879_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-51-FL19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241162
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.458832
GSE149010_0_v_6_dars2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.61615
IRAK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01362
SMAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0831
HCC1500_BREAST	CCLE Cell Line Proteomics	1.0	3.33217
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6059_TENT2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.739136
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7824
ZNF703	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03592
CALM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3882
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PRDM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39232
protein maturation by iron-sulfur cluster transfer	GO Biological Process Annotations 2023	1.0	null
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6396
PMC6977700-aging-12-102667-s004..xlsx-Stage1-The_identified_3126_dysregulated_LmiRM-CTs_in_stage_1_of_MI_1_day_of_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6129
NBTGR	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
Lower epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
GAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31537
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
7910_SIGMAR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51956
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278635
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8616
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100351_FWM_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.52141
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8608
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2675
DLD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28595
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0267
decreased prepulse inhibition	MGI Mouse Phenotype Associations 2023	1.0	null
HslUV protease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.901
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCS-OX2-29	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tassel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
CAPN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19611
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WWC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07069
PMC10203545-Table_4.xlsx-LM7_underrepresented-DMRTA1_DMRTA1	Rummagene Transcription Factor Associations 2026	1.0	null
cas1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.371
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.0756
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07565
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.159
Nuclear MIS12/MIND complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.776
SB 218795	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
10073_ZFC3H1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61776
GSE138815,GSE138817_3_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205070_2_v_7_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NEURL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19777
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
increased circulating HDL cholesterol level	MGI Mouse Phenotype Associations 2023	1.0	null
PMC5263239-mmc2.xls-KOPN-8_-_MLL-ENL-Non-spreading_targets_gene_names_1358_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
FDPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60571
NC-27-AD53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392598
MARK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26441
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP3CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12435
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
ED-81-ZH14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32673
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0475
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284702
FAM169A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03856
increased circulating lipase level	MGI Mouse Phenotype Associations 2023	1.0	null
6887_PSMG4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.549124
GSE166169_0_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7527
PRPF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55648
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8477
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9187
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367927
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8853
GSE160246_0_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
increased circulating cholesterol level	MGI Mouse Phenotype Associations 2023	1.0	null
Human cytomegalovirus infection	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528598
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.7377
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8467_ST20-MTHFS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.658282
SYT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27843
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100536_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37038
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269689
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.18211
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
LOXIMVI_SKIN	CCLE Cell Line Proteomics	1.0	3.34628
COPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41194
Cytosolic large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.418
KLHDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34942
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GLRX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35332